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| For further information please contact Nader Pourmand |
Human papilloma viruses (HPV) are clinically regarded as the most important pathogens of the human urogenital tract and the main etiological factor in the development of cervical cancer. HPVs are a diverse group of DNA viruses involved in human disease, with more than 100 different types identified. HPVs are classified as low-risk or high-risk based on their relative risks of oncogenenesis, making HPV genotyping essential for clinical diagnostics. The present study describes the use of novel probes derived from the E1 open reading frame for rapid and simple typing of HPV using DNA-Chip Microarray technology. Twenty clinically relevant samples have successfully been characterized with respect to their HPV genotypes.
Our long-term goal is to use type specific probe design from different ORFs combined with a bead based technology (Luminex XMAP) for a high-throughput muliplex assay to increase the accuracy and sensitivity of the detection of HPV variants.