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We are now at the beginning of the ``genome age'' in biological
research. Several dozen genomes have been completed since the first
complete bacterial genome was published in 1995 [Fleischmann et al., 1995].
Microbial genome sequencing projects have become common, and major
genome centers are ramping up production to tackle the gigabase
genomes of human and other multicellular eukaryotes. Our capacity to
sequence DNA has far out-paced our ability to characterize individual
gene function experimentally. Now, many thousands of predicted genes
exist in the public databases for which we have little or no
understanding of their biological function. For example, no
functional information is known for more than 50 % of the 19,099
predicted protein coding genes in the recently completed
Caenorhabditis elegans genome [C. elegans Sequencing Consortium, 1998]. Much of
the next era of biological research will involve assigning basic
function to each of these anonymous components, and fitting them into
the massively complex networks of interactions within the cell.
Todd M. Lowe
2000-03-31