Description

The recombination rate track represents calculated sex-averaged rates of recombination based on either the deCODE, Marshfield, or Genethon genetic maps. By default, the deCODE map rates are displayed. Female- and male-specific recombination rates, and well as rates from the Marshfield and Genethon maps, can also be displayed by choosing the appropriate filter option on the track description page.

Methods

The deCODE genetic map was created at deCODE Genetics and is based on 5,136 microsatellite markers for 146 families with a total of 1,257 meiotic events. For more information on this map, see A. Kong et. al., "A high-resolution recombination map of the human genome", Nature Genetics, 31(3), pages 241-247 (2002).

The Marshfield genetic map was created at the Center for Medical Genetics and is based on 8,325 short tandem repeat polymorphisms (STRPs) for 8 CEPH families consisting of 134 individuals with 186 meioses. For more information on this map, see K.W. Broman et. al., "Comprehensive Human Genetic Maps: Individual and Sex-Specific Variation in Recombination", American Journal of Human Genetics 63:861-689 (1998).

The Genethon genetic map was created at Genethon and is based on 5,264 microsatellites for 8 CEPH families consisting of 134 individuals with 186 meioses. For more information on this map, see Dib et. al., "A Comprehensive Genetic Map of the Human Genome Based on 5,264 Microsatellites", Nature, 380, pages 152-154 (1996).

Each base is assigned the recombination rate calculated by assuming a linear genetic distance across the immediately flanking genetic markers. The recombination rate assigned to each 1Mb window is the average recombination rate of the bases contained within the window.

Using the Filter

To view a particular map or gender-specific rate, select the corresponding option from the "Map Distances" pulldown list. By default, the browser displays the deCODE sex-averaged distances.

Credits

This track is produced at UCSC and uses data that are freely available for the Genethon, Marshfield, and deCODE genetic maps (see above links). Thanks to all who have played a part in the creation of these maps.