Description
This track shows predicted transcription factor binding sites
based on sequence similarities upstream of coordinately expressed genes.
In dense mode the gold areas indicate the extent of the area
searched for binding sites and the black boxes indicate the actual
binding sites. In other modes the gold areas disappear and only
the binding sites are displayed. Clicking on a particular predicted binding site brings up
a page which indicates the sequence motif associated with the predicted
transcription factor, and the sequence at the predicted binding site.
Where known motifs have been identified by this method, they are named,
otherwise they are assigned a Motif_ number.
Methods
This analysis was performed according to
Genome-wide discovery of transcriptional modules from DNA sequence and gene
expression on various pre-existing microarray datasets.
A regulatory module is comprised of a set of genes predicted to be regulated by the same
combination of DNA sequence motifs. The predictions are based on the
co-expression of the set of genes in the module and on the appearance of
common combinations of motifs in the upstream regions of genes assigned to
the same module.
Credits
Thanks to Eran Segal for
providing the data analysis that forms the basis for this track. The display
was programmed by Jim Kent.