About the NISC Comparative Sequencing Program Browser

This site contains data generated by the NISC Comparative Sequencing Program, whose goal is to sequence the same targeted genomic regions in multiple vertebrates. Currently, data from the first target - corresponding to a 1.8 Mb region of human chromosome 7q31 - are available on 12 species. Future builds will include data from additional targeted regions and species. The Target 1 data have been released in conjunction with the paper Thomas, J.W. et. al. (2003) Comparative analyses of multi-species sequences from targeted genomic regions. Nature 424:788- 793.

The sequence data represented here were compiled from existing GenBank records. In addition to long-range assembly and standard feature annotation, the results of several analyses are displayed, including pair-wise sequence alignments, intrinsic sequence properties, and sequence comparisons that reveal regions highly conserved across multiple species. Flat files of the assembled sequence and annotations can be obtained from http://www.nisc.nih.gov/data/ or from the Downloads page on this website.

Please review the NISC Comparative Sequencing Program data release and usage policy before making use of these data.

Sample position queries

Position queries for this release of the NISC Comparative Sequencing Program browser are limited to the Target 1 region, which corresponds to a 1.8 Mb portion of human chromosome 7q31. Search requests for features that align outside this region will return a list of non-aligned search results that link to the NCBI Entrez database. To change the species data displayed in the browser, use the Organism pulldown menu (at the top of the annotation tracks page).

The following list provides examples of valid position queries for the NISC Target 1 region. See the User's Guide for more information.

Request:
   Genome Browser Response:

target1 Displays the entire Target 1 region
target1:1309496-1498195 Displays bases 1309496 through 1498195 of the Target 1 region, the position corresponding to the CFTR gene in the human genome

AF234882 Displays region of mRNA with GenBank accession AF234882 (Human)
BI461419 Displays region of EST with GenBank accession BI461419 (Human)
CFTR Displays region with gene-identifier CFTR in the selected species

cystic fibrosis Lists candidate genes associated with cystic fibrosis