This track depicts the conservation score resulting from an analysis of the species represented in the blastz alignments shown in the ZooSeq track.
Conservation scores were generated by weighing the relative contribution of each species sequence to the overall conservation score, based on how diverged each species was from the reference sequence. This weighting scheme was determined by calculating the neutral substitution rates at 4-fold degenerate positions.
Additional information about this conservation score can be found in the paper Margulies, E. et al. (2003) "Identification and Characterization of Multi-Species Conserved Sequences". Genome Res. 13:2507-2518.
This track was generated by Elliott Margulies at NHGRI. Ryan Weber of the UCSC Genome Bioinformatics Group provided the computational support for the track display.