Thanks to Leslie Grate, who wrote an early version of the program used to test regularizers; Kimmen Sjölander for providing the 9-component Dirichlet mixture and comments on this paper; Michael Brown for providing an early implementation of the Dirichlet mixture regularizer; the Henikoffs for providing the BLOCKS database, pre-publication drafts of their papers and comments on early drafts of this paper; and everyone in the compbio group at UCSC for advice and support.