a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- TR429 SDC130H02, Homo sapiens, 178-22-2 residues
- gi|115430235|ref|NP_001041666.1|_130:283 ubiquitin-like, containing PHD and RING finger domains, 1 isoform 1 [Homo sapiens]
- gi|67462077|sp|Q96T88|UHRF1_HUMAN E3 ubiquitin-protein ligase UHRF1 (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106) [Taxonomy]
- gi|14190527|gb|AAK55744.1|AF274048_1 nuclear zinc finger protein Np95 [Homo sapiens]
- gi|54781359|gb|AAV40831.1| ubiquitin-like, containing PHD and RING finger domains, 1 [Homo sapiens]
- gi|117939141|dbj|BAF36719.1| hNP95 [Homo sapiens]
- gi|117939143|dbj|BAF36720.1| hNP95 [Homo sapiens]
- gi|119589593|gb|EAW69187.1| ubiquitin-like, containing PHD and RING finger domains, 1, isoform CRA_a [Homo sapiens]
- gi|148342526|gb|ABQ59043.1| UHRF1 protein [Homo sapiens]
- gi|119589595|gb|EAW69189.1|_194:347 ubiquitin-like, containing PHD and RING finger domains, 1, isoform CRA_c [Homo sapiens]
- gi|115430233|ref|NP_037414.3|_143:296 ubiquitin-like, containing PHD and RING finger domains, 1 isoform 2 [Homo sapiens]
- gi|119589594|gb|EAW69188.1| ubiquitin-like, containing PHD and RING finger domains, 1, isoform CRA_b [Homo sapiens]
- gi|158259801|dbj|BAF82078.1|_130:283 unnamed protein product [Homo sapiens]
- gi|189069490|dbj|BAG37156.1|_130:283 unnamed protein product [Homo sapiens]
- gi|116138198|gb|AAI13876.2|_143:296 Ubiquitin-like, containing PHD and RING finger domains, 1 [Homo sapiens]
- gi|167773777|gb|ABZ92323.1| ubiquitin-like, containing PHD and RING finger domains, 1 [synthetic construct]
- gi|114674773|ref|XP_001139655.1|_130:283 PREDICTED: ubiquitin-like, containing PHD and RING finger domains, 1 isoform 1 [Pan troglodytes]
- gi|114674775|ref|XP_001139745.1| PREDICTED: ubiquitin-like, containing PHD and RING finger domains, 1 isoform 2 [Pan troglodytes]
- gi|114674777|ref|XP_512293.2| PREDICTED: ubiquitin-like, containing PHD and RING finger domains, 1 isoform 4 [Pan troglodytes]
- gi|114674779|ref|XP_001139916.1| PREDICTED: ubiquitin-like, containing PHD and RING finger domains, 1 isoform 3 [Pan troglodytes]
- gi|6815251|gb|AAF28469.1|AF129507_1_130:283 transcription factor ICBP90 [Homo sapiens]
- gi|73987096|ref|XP_854422.1|_133:286 PREDICTED: similar to ubiquitin-like, containing PHD and RING finger domains, 1 isoform 1 [Canis familiaris]
- gi|73987098|ref|XP_868468.1|_133:286 PREDICTED: similar to ubiquitin-like, containing PHD and RING finger domains, 1 isoform 5 [Canis familiaris]
- gi|73987094|ref|XP_868462.1|_133:286 PREDICTED: similar to ubiquitin-like, containing PHD and RING finger domains, 1 isoform 4 [Canis familiaris]
- gi|73987090|ref|XP_868453.1|_133:288 PREDICTED: similar to ubiquitin-like, containing PHD and RING finger domains, 1 isoform 2 [Canis familiaris]
- gi|73987092|ref|XP_868458.1|_133:288 PREDICTED: similar to ubiquitin-like, containing PHD and RING finger domains, 1 isoform 3 [Canis familiaris]
- gi|109123024|ref|XP_001082893.1|_130:285 PREDICTED: similar to ubiquitin-like, containing PHD and RING finger domains, 1 isoform 2 [Macaca mulatta]
- gi|109123026|ref|XP_001082762.1| PREDICTED: similar to ubiquitin-like, containing PHD and RING finger domains, 1 isoform 1 [Macaca mulatta]
- gi|109123028|ref|XP_001083019.1| PREDICTED: similar to ubiquitin-like, containing PHD and RING finger domains, 1 isoform 3 [Macaca mulatta]
- gi|109123030|ref|XP_001083134.1| PREDICTED: similar to ubiquitin-like, containing PHD and RING finger domains, 1 isoform 4 [Macaca mulatta]
- gi|149028206|gb|EDL83644.1|_125:280 ubiquitin-like, containing PHD and RING finger domains, 1 (mapped), isoform CRA_a [Rattus norvegicus]
- gi|67461836|sp|Q7TPK1|UHRF1_RAT_125:280 E3 ubiquitin-protein ligase UHRF1 (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Liver regeneration-related protein LRRG126) [Taxonomy]
- gi|57114344|ref|NP_001008882.1|_180:335 ubiquitin-like, containing PHD and RING finger domains, 1 [Rattus norvegicus]
- gi|32527729|gb|AAP86266.1| Ac2-121 [Rattus norvegicus]
- gi|148706214|gb|EDL38161.1|_169:324 ubiquitin-like, containing PHD and RING finger domains, 1, isoform CRA_a [Mus musculus]
- gi|74147355|dbj|BAE27560.1|_125:280 unnamed protein product [Mus musculus]
- gi|74208423|dbj|BAE26398.1|_125:280 unnamed protein product [Mus musculus]
- gi|161621273|ref|NP_001104550.1|_125:280 ubiquitin-like, containing PHD and RING finger domains, 1 isoform B [Mus musculus]
- gi|162287241|ref|NP_001104549.1| ubiquitin-like, containing PHD and RING finger domains, 1 isoform B [Mus musculus]
- gi|74151003|dbj|BAE27632.1| unnamed protein product [Mus musculus]
- gi|74198788|dbj|BAE30624.1|_125:280 unnamed protein product [Mus musculus]
- gi|17939938|dbj|BAB79496.1|_125:280 Np95 [Mus musculus]
- gi|18380940|gb|AAH22167.1|_125:280 Ubiquitin-like, containing PHD and RING finger domains, 1 [Mus musculus]
- gi|161621269|ref|NP_035061.3|_125:280 ubiquitin-like, containing PHD and RING finger domains, 1 isoform A [Mus musculus]
- gi|161621271|ref|NP_001104548.1| ubiquitin-like, containing PHD and RING finger domains, 1 isoform A [Mus musculus]
- gi|67462071|sp|Q8VDF2|UHRF1_MOUSE E3 ubiquitin-protein ligase UHRF1 (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Nuclear zinc finger protein Np95) (Nuclear protein 95) [Taxonomy]
- gi|14190525|gb|AAK55743.1|AF274046_1 nuclear zinc finger protein Np95 [Mus musculus]
- gi|4220590|dbj|BAA74579.1| nuclear protein np95 [Mus musculus]
- gi|74150733|dbj|BAE25499.1| unnamed protein product [Mus musculus]
- gi|74211529|dbj|BAE26496.1| unnamed protein product [Mus musculus]
- gi|74139714|dbj|BAE31708.1|_125:280 unnamed protein product [Mus musculus]
- gi|74199030|dbj|BAE30730.1| unnamed protein product [Mus musculus]
- gi|74219676|dbj|BAE29605.1| unnamed protein product [Mus musculus]
- gi|74225350|dbj|BAE31605.1| unnamed protein product [Mus musculus]
- gi|126323137|ref|XP_001365790.1|_132:288 PREDICTED: similar to ubiquitin-like, containing PHD and RING finger domains, 1 [Monodelphis domestica]
- gi|148709750|gb|EDL41696.1|_215:405 ubiquitin-like, containing PHD and RING finger domains 2, isoform CRA_a [Mus musculus]
- gi|26348883|dbj|BAC38081.1|_122:312 unnamed protein product [Mus musculus]
- gi|124430766|ref|NP_659122.2|_122:312 ubiquitin-like, containing PHD and RING finger domains 2 [Mus musculus]
- gi|67462063|sp|Q7TMI3|UHRF2_MOUSE E3 ubiquitin-protein ligase UHRF2 (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF) [Taxonomy]
- gi|33589239|dbj|BAC81739.1| Np95-like ring finger protein [Mus musculus]
- gi|37805363|gb|AAH60241.1| Ubiquitin-like, containing PHD and RING finger domains 2 [Mus musculus]
- gi|148709751|gb|EDL41697.1| ubiquitin-like, containing PHD and RING finger domains 2, isoform CRA_b [Mus musculus]
- gi|21069047|gb|AAM33798.1|AF274047_1_122:312 nuclear zinc finger protein Np97 [Mus musculus]
- gi|23312364|ref|NP_690856.1|_121:311 Np95-like ring finger protein [Homo sapiens]
- gi|67462076|sp|Q96PU4|UHRF2_HUMAN E3 ubiquitin-protein ligase UHRF2 (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear zinc finger protein Np97) (RING finger protein 107) [Taxonomy]
- gi|21069049|gb|AAM33799.1|AF274049_1 nuclear zinc finger protein Np97 [Homo sapiens]
- gi|15667627|dbj|BAB68317.1| Np95-like ring finger protein [Homo sapiens]
- gi|55662522|emb|CAH74119.1| ubiquitin-like, containing PHD and RING finger domains, 2 [Homo sapiens]
- gi|55957137|emb|CAI13293.1| ubiquitin-like, containing PHD and RING finger domains, 2 [Homo sapiens]
- gi|119579147|gb|EAW58743.1| hCG2011540, isoform CRA_b [Homo sapiens]
- gi|168278369|dbj|BAG11064.1| E3 ubiquitin-protein ligase UHRF2 [synthetic construct]
- gi|20306314|gb|AAH28397.1|_121:311 UHRF2 protein [Homo sapiens]
- gi|157928904|gb|ABW03737.1| ubiquitin-like, containing PHD and RING finger domains, 2 [synthetic construct]
- gi|157821129|ref|NP_001101055.1|_122:312 ubiquitin-like, containing PHD and RING finger domains 2 [Rattus norvegicus]
- gi|149062687|gb|EDM13110.1| ubiquitin-like, containing PHD and RING finger domains 2 (predicted) [Rattus norvegicus]
- gi|114623729|ref|XP_001142916.1|_121:311 PREDICTED: Np95-like ring finger protein isoform 1 [Pan troglodytes]
- gi|157928214|gb|ABW03403.1|_121:311 ubiquitin-like, containing PHD and RING finger domains, 2 [synthetic construct]
- gi|114623731|ref|XP_528534.2|_121:311 PREDICTED: Np95-like ring finger protein isoform 2 [Pan troglodytes]
- gi|149736987|ref|XP_001492651.1|_117:307 PREDICTED: similar to Np95-like ring finger protein [Equus caballus]
- gi|156718126|ref|NP_001096568.1|_136:287 ubiquitin-like, containing PHD and RING finger domains, 1 [Bos taurus]
- gi|154757485|gb|AAI51672.1| UHRF1 protein [Bos taurus]
- gi|73970974|ref|XP_864420.1|_122:281 PREDICTED: similar to Np95-like ring finger protein isoform b isoform 6 [Canis familiaris]
- gi|73970972|ref|XP_864401.1|_122:281 PREDICTED: similar to Np95-like ring finger protein isoform b isoform 5 [Canis familiaris]
- gi|73970966|ref|XP_851749.1|_122:312 PREDICTED: similar to Ubiquitin-like containing PHD and RING finger domains protein 2 (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF) isoform 2 [Canis familiaris]
- gi|73970976|ref|XP_531928.2|_122:312 PREDICTED: similar to Ubiquitin-like containing PHD and RING finger domains protein 2 (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF) isoform 1 [Canis familiaris]
- gi|156121185|ref|NP_001095740.1|_122:312 Np95-like ring finger protein [Bos taurus]
- gi|151555668|gb|AAI48950.1| UHRF2 protein [Bos taurus]
- gi|149269388|ref|XP_001477928.1|_125:277 PREDICTED: hypothetical protein [Mus musculus]
- gi|118103345|ref|XP_418269.2|_111:268 PREDICTED: similar to ubiquitin-like, containing PHD and RING finger domains, 1 [Gallus gallus]
- gi|47085807|ref|NP_998242.1|_131:277 ubiquitin-like, containing PHD and RING finger domains, 1 [Danio rerio]
- gi|34783763|gb|AAH58055.1| Ubiquitin-like, containing PHD and RING finger domains, 1 [Danio rerio]
- gi|94734040|emb|CAK04045.1|_131:277 ubiquitin-like, containing PHD and RING finger domains, 1 [Danio rerio]
- gi|49618893|gb|AAT68031.1|_131:277 NP95 [Danio rerio]
- gi|73970970|ref|XP_864378.1|_122:267 PREDICTED: similar to Np95-like ring finger protein isoform b isoform 4 [Canis familiaris]
- gi|62739288|gb|AAH94105.1|_127:281 LOC432234 protein [Xenopus laevis]
- gi|47938721|gb|AAH72079.1|_127:281 LOC432234 protein [Xenopus laevis]
- gi|83405203|gb|AAI10934.1|_127:281 LOC432234 protein [Xenopus laevis]
- gi|156717408|ref|NP_001096244.1|_119:307 hypothetical protein LOC100124801 [Xenopus tropicalis]
- gi|134025409|gb|AAI35390.1| LOC100124801 protein [Xenopus tropicalis]
- gi|148224431|ref|NP_001091384.1|_120:307 Np95-like ring finger protein [Xenopus laevis]
- gi|118764339|gb|AAI28674.1| Uhrf2 protein [Xenopus laevis]
- gi|47216586|emb|CAG00621.1|_133:285 unnamed protein product [Tetraodon nigroviridis]
- gi|126335637|ref|XP_001365488.1|_125:313 PREDICTED: hypothetical protein isoform 2 [Monodelphis domestica]
- gi|126335635|ref|XP_001365423.1|_125:313 PREDICTED: hypothetical protein isoform 1 [Monodelphis domestica]
- gi|149634869|ref|XP_001507628.1|_160:350 PREDICTED: hypothetical protein [Ornithorhynchus anatinus]
- gi|73970968|ref|XP_864358.1|_122:267 PREDICTED: similar to Np95-like ring finger protein isoform b isoform 3 [Canis familiaris]
- gi|47223598|emb|CAF99207.1|_198:402 unnamed protein product [Tetraodon nigroviridis]
- gi|125847356|ref|XP_001338282.1|_100:294 PREDICTED: similar to ubiquitin-like, containing PHD and RING finger domains 2, partial [Danio rerio]
- gi|156382373|ref|XP_001632528.1|_128:283 predicted protein [Nematostella vectensis]
- gi|156219585|gb|EDO40465.1| predicted protein [Nematostella vectensis]
- gi|91077828|ref|XP_971012.1|_104:243 PREDICTED: similar to NP95 [Tribolium castaneum]
- gi|156545123|ref|XP_001602205.1|_117:258 PREDICTED: similar to NP95 [Nasonia vitripennis]
- gi|118344046|ref|NP_001071846.1|_119:253 UHRF2 protein [Ciona intestinalis]
- gi|70571420|dbj|BAE06743.1| Ci-UHRF2 [Ciona intestinalis]
- gi|189240385|ref|XP_001807192.1|_155:281 PREDICTED: similar to predicted protein [Tribolium castaneum]
- gi|115644369|ref|XP_791602.2|_36:146 PREDICTED: hypothetical protein [Strongylocentrotus purpuratus]
- gi|115970044|ref|XP_001176738.1| PREDICTED: hypothetical protein [Strongylocentrotus purpuratus]
- gi|55662523|emb|CAH74120.1|_2:88 ubiquitin-like, containing PHD and RING finger domains, 2 [Homo sapiens]
- gi|55957139|emb|CAI13295.1| ubiquitin-like, containing PHD and RING finger domains, 2 [Homo sapiens]
- gi|119579146|gb|EAW58742.1|_2:88 hCG2011540, isoform CRA_a [Homo sapiens]
- gi|74196808|dbj|BAE43129.1|_108:201 unnamed protein product [Mus musculus]
- gi|26326961|dbj|BAC27224.1|_122:215 unnamed protein product [Mus musculus]
- gi|26334573|dbj|BAC30987.1| unnamed protein product [Mus musculus]
- gi|26342176|dbj|BAC34750.1| unnamed protein product [Mus musculus]
- gi|26335045|dbj|BAC31223.1|_122:162 unnamed protein product [Mus musculus]
- gi|67967595|dbj|BAE00280.1|_121:160 unnamed protein product [Macaca fascicularis]

              10        20        30        40             50          
              |         |         |         |              |          
   1 ETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEP.....CSSTSRPALEE..DVIYHV
   2 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEP.....CSSTSRPALEE..DVIYHV
   3 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEP.....CSSTSRPALEE..DVIYHV
   4 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEP.....CSSTSRPALEE..DVIYHV
   5 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEP.....CSSTSRPALEE..DVIYHV
   6 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEP.....CSSTSRPALEE..DVIYHV
   7 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEP.....CSSTSRPALEE..DVIYHV
   8 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEP.....CSSTSRPALEE..DVIYHV
   9 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEP.....CSSTSRPALEE..DVIYHV
  10 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSQDEP.....CSSTSSSTPED..DVIYHV
  11 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSQDEP.....CSSTSSSTPED..DVIYHV
  12 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSQDEP.....CSSTSSSTPED..DVIYHV
  13 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSQDEP.....CSSTSSSTPED..DVIYHV
  14 -TELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSQDEP.....CSSTSSSTPED..DVIYHV
  15 -TEMGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEP.....CSSTSSPALEEdaDVIYHV
  16 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKKALSEEEP.....CSSSAIMAPED..DIMYHI
  17 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKKALSEEEP.....CSSSAIMAPED..DIMYHI
  18 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKKALSEEEP.....CSSSAIMAPED..DIMYHI
  19 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEP.....CSSSAVKTSED..DIMYHV
  20 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEP.....CSSSAVKTSED..DIMYHV
  21 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEP.....CSSSAVKTSED..DIMYHV
  22 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEP.....CSSSAVKTSED..DIMYHV
  23 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEP.....CSSSAVKTSED..DIMYHV
  24 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEP.....CSSSAVKTSED..DIMYHV
  25 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEP.....CSSSAVKTSED..DIMYHV
  26 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEP.....CSSSAVKTSED..DIMYHV
  27 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEP.....CSSSAVKTSED..DIMYHV
  28 DPGFGLYKINEYVDARDMNMGAWFEGILVNVTRKEREASES.....SDNEDGQVAEE..DVIYHV
  29 DPGFGLYKVNELVDARDVGLGAWFEAHIHSVTRASDGHSRGk33psTSNSDSVAADE..DVIYHI
  30 DPGFGLYKVNELVDARDVGLGAWFEAHIHSVTRASDGHSRGk33psTSNSDSVAADE..DVIYHI
  31 DPGFGLYKVNELVDARDVGLGAWFEAHIHSVTRASDGHSRGk33psTSNSDSVAADE..DVIYHI
  32 DPGFGLYKVNELVDARDVGLGAWFEAHIHSVTRASDGHSRGk33psTSNSDSVAADE..DVIYHI
  33 DPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGk33psTSNSDCVAADE..DVIYHI
  34 DPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGk33psTSNSDCVAADE..DVIYHI
  35 DPGFGLYKVNELVDARDAGLGAWFEAHIHSVTRASDGHSRGk33psTSNSDSVAADE..DVIYHI
  36 DPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGk33psTSNSDCVAADE..DVIYHI
  37 DPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGk33psTSNSDCVAADE..DVIYHI
  38 DPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGk33psTSNSDCVAADE..DVIYHI
  39 DPGIGIYKVNELVDARDVGLGAWFEARIHSVTRASDGHSRGk33psTSNSDSVAADE..DVIYHI
  40 -TELGLYKVGEYVDARDTNMGAWFEAKVIRVTRKAPAHDQP.....SSSSS--KPED..DIIYHV
  41 DPGIGLYKVNELVDARDVGLGAWFEARIRSVTRNTNKLDSVps...TSNSDSVAADE..DVIYHI
  42 DPGIGLYKVNELVDARDVGLGAWFEARIRSVTRNTNKLDSVps...TSNSDSVAADE..DVIYHI
  43 DPGIGLYKVNELVDARDVGLGAWFEARIRSVTRASDGHSRGk33psTSNSDSVAADE..DVIYHI
  44 DPGIGLYKVNELVDARDVGLGAWFEARIRSVTRASDGHSRGk33psTSNSDSVAADE..DVIYHI
  45 DPGIGLYKVNELVDARDVALGAWFEARIHSVTRASDGHSRGk33psTSNSDSVAADE..DVIYHI
  46 DTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEP.....CSSSAVKTSED..DIMYHV
  47 DPGFGLYKIHDLVDARDMNMGAWFEAQVVNVTRRKAANESCa....VADQQTTIPEE..DVIYHV
  48 DPGFGFYKINEFVDARDLNMGAWFEAQIVKVTKTPAEDGGP.....----------E..EIVYHV
  49 DPGFGFYKINEFVDARDLNMGAWFEAQIVKVTKTPAEDG--.....--------GAE..DIVYHV
  50 DPGFGFYKINEFVDARDLNMGAWFEAQIVKVTKTPAEDG--.....--------GAE..SIVYHV
  51 DPGIGLYKVNELVDARDVGLGAWFEARIRSVTRASDGHS--.....----------R..DVIYHI
  52 --GTSLYKKNDLVDARDLNMGAWFEAQIVNVSKKVGPYGTL.....PEVSDTSVTSD..AIIYHV
  53 --GTSLYKKNDLVDARDLNMGAWFEAQIVNVSKKVGPYGTL.....PEVSDTSVTSD..AIIYHV
  54 --GTSLYKKNDLVDARDLNMGAWFEAQIVNVSKKVGPYGTL.....PEVSDTSVTSD..AIIYHV
  55 DPGIGIYKINELVDARDVSIGAWFEAHVENVTQKKAQKNGKa31psTSYNDILDEDE..NVIYHI
  56 DPGIGIYKINELVDARDVSIGSWFEAHVENVTQNKKAQKNGk30psTSYNDILDDNE..NVIYHI
  57 DPGFGLYKLNELVDARDLNMGAWFEAQIVNVTKTPKTPEEG.....AGEG---RAEE..EILYHV
  58 DPGIGIYKINELVDARDDTLGAWFEAHIKSVSSATKQHKSGk32apSTSPSNSMNSE..DIIYHI
  59 DPGIGIYKINELVDARDDTLGAWFEAHIKSVSSATKQHKSGk32apSTSPSNSMNSE..DIIYHI
  60 DPGIGLYKVNELVDARDVSIGAWFEAHIENVTRVAKGHKNGk33apSTSYSDSMDTE..EAIYHI
  61 DPGIGLYKVNELVDARDVGLGAWFEARIRSVTRASDGHS--.....----------R..DVIYHI
  62 DPGIGVYKINELVDCRDVSIGAWFEACVEKVTRAPKGQITPt47dsTAAAETKEREE..DAVYHI
  63 DPGIGVFKVNELVDCRDVSIGAWFEAVIEKVSPASKAQKNKd37taADRLTTDSSTD..RVSYHI
  64 ----SIYKKGEFIDAKDPSMGAWFEAEIVDISLKDESD---.....---------PE..SVLYHV
  65 ----RYYEIGDKIDVIDSDHGAWFEAKILGIFKPKETEN--.....-------ADEK..DLTFRI
  66 -AESQYYKVGDAVDCTDNALGAWFEAVIVKIFTKSEK----.....-----------..-LFYKV
  67 ----GLYKINALIDAQDTDVGAWFEAKVVNVTKGK------.....---------TD..GLDYHI
  68 -------------------FGAWFEAKIIEILVDQNNDN--.....--------AEE..NLIFKV
  69 -----------------------------------------.....---DSHWTRHD..GLIYHV
  70 -----------------------------------------.....-----------..------
  71 -----------------------------------------.....-----------..------
  72 DPGFGLYKVNELVDARDVGLGAWFEAHIHSVTRASDGHSRGk33psTSNSDSVAADE..DVIYHI
  73 DPGFGLYKVNELVDARDVGLGAWFEAHIHSVTRASDGHSRGk33psTSNSDSVAADE..DVIYHI
  74 DPGFGLYKVNELVDARDVGLGAWFEAHIHSVTRASDGHSRG.....-----------..------
  75 DPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSR-.....-----------..------


      60          70        80        90       100       110       120 
      |           |         |         |         |         |         | 
   1 KYD..DYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRET
   2 KYD..DYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRET
   3 KYD..DYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRET
   4 KYD..DYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRET
   5 KYD..DYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRET
   6 KYD..DYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRET
   7 KYD..DYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRET
   8 KYD..DYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRET
   9 KYD..DYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRET
  10 KYD..DYPENGVVQMSSRDVRARARNILKWQELEVGQVVMLNYNPDNPKERGFWYDAEILRKRET
  11 KYD..DYPENGVVQMSSRDVRARARNILKWQELEVGQVVMLNYNPDNPKERGFWYDAEILRKRET
  12 KYD..DYPENGVVQMSSRDVRARARNILKWQELEVGQVVMLNYNPDNPKERGFWYDAEILRKRET
  13 KYD..DYPENGVVQMSSRDVRARARNILKWQELEVGQVVMLNYNPDNPKERGFWYDAEILRKRET
  14 KYD..DYPENGVVQMSSRDVRARARNILKWQELEVGQVVMLNYNPDNPKERGFWYDAEILRKRET
  15 KYD..DYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRET
  16 KYD..DYPEHGVDIVKAKNVRARARTVIPWEDLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  17 KYD..DYPEHGVDIVKAKNVRARARTVIPWEDLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  18 KYD..DYPEHGVDIVKAKNVRARARTVIPWEDLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  19 KYD..DYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  20 KYD..DYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  21 KYD..DYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  22 KYD..DYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  23 KYD..DYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  24 KYD..DYPEHGVDIVKAKNVRARARTVIPWENLKVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  25 KYD..DYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  26 KYD..DYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  27 KYD..DYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  28 KYE..DYPENGVVKLSSKDVRARARTILKWHQLEVGQIVMVNYNPDEPKERGFWYDAEILRKRET
  29 EYD..EYPESGILEMNVKDLRPRARTILKWNELNVGDVVMVNYNVENPGKRGFWYDAEITTLKTI
  30 EYD..EYPESGILEMNVKDLRPRARTILKWNELNVGDVVMVNYNVENPGKRGFWYDAEITTLKTI
  31 EYD..EYPESGILEMNVKDLRPRARTILKWNELNVGDVVMVNYNVENPGKRGFWYDAEITTLKTI
  32 EYD..EYPESGILEMNVKDLRPRARTILKWNELNVGDVVMVNYNVENPGKRGFWYDAEITTLKSI
  33 QYD..EYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTI
  34 QYD..EYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTI
  35 EYD..EYPESGTLEMNAKELRPRARTILKWNELNVGDVVMVNYNVENPGKRGFWYDAEITTLKTI
  36 QYD..EYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTI
  37 QYD..EYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTI
  38 QYD..EYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTI
  39 EYD..EYPESGTVEINVKDLRPRARTTLKWNELNVGDVVMVNYNVENPGNRGFWFDAEITALKTI
  40 TYD..DYPENGVVQMTSQNVRARARHTIKWEDLQVGQVVMVNYNPDLPKDRGFWYDAEILRKRET
  41 EYD..EYPESGTVEINVKDLRPRARTNLKWNELNVGDVVMVNYSVENPGNRGFWFDAEITALKTI
  42 EYD..EYPESGTVEINVKDLRPRARTNLKWNELNVGDVVMVNYSVENPGNRGFWFDAEITALKTI
  43 EYD..EYPESGTVEINVKDLRPRARTNLKWNELNVGDVVMVNYSVENPGNRGFWFDAEITALKTI
  44 EYD..EYPESGTVEINVKDLRPRARTNLKWNELNVGDVVMVNYSVENPGNRGFWFDAEITALKTI
  45 EYD..EYPESGTVEINVKDLRPRARTTLRWNELNVGDVVMVNYNVESPSNRGFWFDAEITTLKTI
  46 ---..NYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQT
  47 KYE..DYPENGVVELSSNDVRSRARTILKWHQLEVGQVVMVNYNPDEPTERGFWYDAEILQKRET
  48 KYE..DYPENGVVQLRGKDVRPRARTVYQWRQLEPGMIVMVNYNPDDPKERGYWYDAEIQRKRET
  49 KYE..DYPENGVVQLRGKDVRPRARTVYQWHQLEPGMIVMVNYNPDDPKERGYWYDAEIQRKRET
  50 KYE..DYPENGVVQLRGKDVRPRARTVYQWHQLEPGMIVMVNYNPDDPKERGYWYDAEIQRKRET
  51 EYD..EYPESGTVEINVKDLRPRARTNLKWNELNVGDVVMVNYSVENPGNRGFWFDAEITALKTI
  52 KYE..DYPENGVVQLTCKDVRLRARTTLPWHEIKVGQVVMVNYNPDEPKERGYWYDAEILRKHES
  53 KYE..DYPENGVVQLTCKDVRLRARTTLPWHEIKVGQVVMVNYNPDEPKERGYWYDAEILRKHES
  54 KYE..DYPENGVVQLTCKDVRLRARTTLPWHEIKVGQVVMVNYNPDEPKERGYWYDAEILRKHES
  55 KYD..DYPENGLVEMDLSNLRPRARTLLKWSDLKTGDKVMVNYNVETPEERGFWFDAEITELKEM
  56 KYD..DYPENGLVEMDLSNLRPRARTLLKWSDLKIGDKVMVNYNVETPEERGFWFDAEITNLKEM
  57 KFE..DYPENGVIQLLGKDVRPRARTVYQWHQLEAGMIVMVNYNPDDPKERGYWYDAEIQRKRET
  58 EYD..EYPENGIIEMRSKNLRPRARKTLKWNELKVGDLVMVNYNVDTPEERGFWYDAEITTLKEI
  59 EYD..EYPENGIIEMRSKNLRPRARKTLKWNELKVGDLVMVNYNVDTPEERGFWYDAEITTLKEI
  60 KYD..EYPENGIIEMGASNLRPRARTILKWNELNVGDVVMVNYNVETPEERGFWFDAEITTLREI
  61 EYD..EYPESGTVEINVKDLRPRARTNLKWNELNVGDVVMVNYSVENPGNRGFWFDAEITALKTI
  62 KYE..DYPENGVVAMKPVDVRPRARTLLRWDQLQVGMRVMVNYNLETPEERGFWFDAEVQTVNQT
  63 RYE..DYPENGVVEMSVSDVRPRARTLLRFDQLSVGDVVMVNHNLELPEERGFWYDAEITALNAV
  64 KYD..GYEEDEINKLPGRDIRPRARKRLQWDQLSVGQVVMANYCPDEPKERGFWYDVQITKKHSK
  65 KMD..RNGNTAAFDVTFSEIRPRAYYTYHKSELTPGVIVLANYNIEEPTSRGYWYDFEIKEI--T
  66 RWDlpETKNDEPFNIEEKFIRPRAWKVLNFNDLDIGQKVMVNYNLEDPKEIGNWYDFTISKIKNT
  67 KFD..DYGDDGVKVVGEKLIRPRARKLLEWNEIEVTSKVMANYNMDHPKERGFWYDCVVLDKKNK
  68 VMD..RNEETAPITVTFNNVRPRAKYIYSFSELQNEMIVFVNYNIEEPTKRGYWYDFKITNINRE
  69 KYE..GYDEEGIAKISSRSIRPRARTMIDYEDVNVGDIVMVNYNCDEPKQRGYWYDMVVKNKKET
  70 ---..----------NVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTI
  71 ---..----------NVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTI
  72 EYD..------------------------------------------------------------
  73 EYD..------------------------------------------------------------
  74 ---..------------------------------------------------------------
  75 ---..------------------------------------------------------------


                 130                 140       150     
                  |                   |         |     
   1 RTARELY.....ANV.VLG..D...D....SLNDCRIIFVDEVFKIERP
   2 RTARELY.....ANV.VLG..D...D....SLNDCRIIFVDEVFKIERP
   3 RTARELY.....ANV.VLG..D...D....SLNDCRIIFVDEVFKIERP
   4 RTARELY.....ANV.VLG..D...D....SLNDCRIIFVDEVFKIERP
   5 RTARELY.....ANV.VLG..D...D....SLNDCRIIFVDEVFKIERP
   6 RTARELY.....ANV.VLG..D...D....SLNDCRIIFVDEVFKIERP
   7 RTARELY.....ANV.VLG..D...D....SLNDCRIIFVDEVFKIERP
   8 RTARELY.....ANV.VLG..D...D....SLNDCRIIFVDEVFKIERP
   9 RTARELY.....ANV.VLG..D...D....SLNDCRIIFVDEVFKIERP
  10 RTARELY.....ANV.RIG..G...D....SLNDCRIIFVDEVFKIEHP
  11 RTARELY.....ANV.RIG..G...D....SLNDCRIIFVDEVFKIEHP
  12 RTARELY.....ANV.RIG..G...D....SLNDCRIIFVDEVFKIEHP
  13 RTARELY.....ANV.RIGsaG...D....SLNDCRIIFVDEVFKIEHP
  14 RTARELY.....ANV.RIGsaG...D....SLNDCRIIFVDEVFKIEHP
  15 RTARELY.....ANV.VLG..D...D....SLNDCRIIFVDEVFKIERP
  16 RTARELY.....GNVmLLN..D...S....QLNNCRIIFVDEVLKIELP
  17 RTARELY.....GNVmLLN..D...S....QLNNCRIIFVDEVLKIELP
  18 RTARELY.....GNVmLLN..D...S....QLNNCRIIFVDEVLKIELP
  19 RTARELY.....GNIrLLN..D...S....QLNNCRIMFVDEVLMIELP
  20 RTARELY.....GNIrLLN..D...S....QLNNCRIMFVDEVLMIELP
  21 RTARELY.....GNIrLLN..D...S....QLNNCRIMFVDEVLMIELP
  22 RTARELY.....GNIrLLN..D...S....QLNNCRIMFVDEVLMIELP
  23 RTARELY.....GNIrLLN..D...S....QLNNCRIMFVDEVLMIELP
  24 RTARELY.....GNIrLLN..D...S....QLNNCRIMFVDEVLMIELP
  25 RTARELY.....GNIrLLN..D...S....QLNNCRIMFVDEVLMIELP
  26 RTARELY.....GNIrLLN..D...S....QLNNCRIMFVDEVLMIELP
  27 RTARELY.....GNIrLLN..D...S....QLNNCRIMFVDEVLMIELP
  28 RTVKEIY.....ANL.LLG..Dag.D....SLNDCRITFVDEVYKIEEP
  29 SRTKKEVrvk..VFL.GGS..E...G....TLNDCRVMSVDEIFKIEKP
  30 SRTKKEVrvk..VFL.GGS..E...G....TLNDCRVMSVDEIFKIEKP
  31 SRTKKEVrvk..VFL.GGS..E...G....TLNDCRVMSVDEIFKIEKP
  32 SRSKKEVrvk..VFL.GGS..E...G....TLNDCRVMSVDEIFKIEKP
  33 SRTKKELrvk..IFL.GGS..E...G....TLNDCKIISVDEIFKIERP
  34 SRTKKELrvk..IFM.GGS..E...G....TLNDCKIISVDEIFKIERP
  35 SRTKKEVrvk..VFL.GGS..E...G....TLNDCRVMFVDEIFKIEKP
  36 SRTKKELrvk..IFL.GGS..E...G....TLNDCKIISVDEIFKIERP
  37 SRTKKELrvk..IFM.GGS..E...G....TLNDCKIISVDEIFKIERP
  38 SRTKKELrvk..IFL.GGS..E...G....TLNDCKIISVDEIFKIERP
  39 SRTKKELhvn..IFL.GGS..E...G....KLNDCQITFVNEIFKIEKP
  40 RTARELH.....ANV.RIG..G...D....SLNDCRIVFVDEVFKIERP
  41 SRTKKELrvn..IIL.GGS..E...G....KLNDCQIRFVNEIFKIEKP
  42 SRTKKELrvn..IIL.GGS..E...G....KLNDCQIRFVNEIFKIEKP
  43 SRTKKELrvn..IIL.GGS..E...G....KLNDCQIRFVNEIFKIEKP
  44 SRTKKELrvn..IIL.GGS..E...G....KLNDCQIRFVNEIFKIEKP
  45 SRTKKELrvt..VFL.GGS..E...G....KLNDCQIRFINEIFKIEKP
  46 RTARELY.....GNIrLLN..D...S....QLNNCRIMFVDEVLMIELP
  47 KLIREIN.....AKI.LLG..Eag.D....SLNDCRIIFVDDIYKIEEP
  48 RTQREVF.....GKI.LLG..Dag.D....SLNDCRIMFVTEIYKIEEP
  49 RTQREVF.....GKI.LLG..Dag.D....SLNDCRIMFVTEIYKIEEP
  50 RTQREVF.....GKI.LLG..Dag.D....SLNDCRIMFVTEIYKIEEP
  51 SRTKKELrvn..IIL.GGS..E...G....KLNDCQIRFVNEIFKIEKP
  52 KKIKEIY.....AKV.LLG..Dag.D....SLNDCRIRFVNEIYKIEEP
  53 KKIKEIY.....AKV.LLG..Dag.D....SLNDCRIRFVNEIYKIEEP
  54 KKIKEIY.....AKV.LLG..Dag.D....SLNDCRIRFVNEIYKIEEP
  55 SRTNKEVfak..IFL.GGS..V...D....VINDCKINFADEIYKIEKP
  56 SRTNKDVfak..IFL.GGP..V...D....VIDDCKIHFADEIYKIEKP
  57 RTLREIY.....AKI.ILG..Dag.D....SLNDCRIIFLTEIYKIEE-
  58 SRTNKEVhak..IML.GGP..E...D....AINDCKILFIDEVYKIEK-
  59 SRTNKEVhak..IML.GGP..E...D....AINDCKILFIDEVYKIEK-
  60 SRTNKEVhak..IML.GEE..Q...A....QLNNQSMVFIEEVFKIRRP
  61 SRTKKELrvn..IIL.GGS..E...G....KLNDCQIRFVNEIFKIEKP
  62 SRTSKELrvk..ILL.GGP..G...D....VIGDCKVQFLDEIYQVEKP
  63 SRTNKEIrvn..ILL.GGP..G...D....VISDCKLHFLEEVYQIEKP
  64 QITQGGAe11lhAKL.ILS..Need-shapVAQECRLIFLDEIFKIEAP
  65 KKGIKGA.....LLV.GTE..L...A....RLENCTTQFVDELLRIENP
  66 KSAKELI.....GTI.HIG..Dst.R....SVDDCTINTKLDILEIEKP
  67 RKKNELT.....VQL.LLG..En..R....TLEPCNITFVEEVFVIE--
  68 KNTLEGN.....LIM.GLSr.E...A....VVHDCIVKFVDEVMKIEQP
  69 RSYKELAgd...ILL.GPS..G...D....VLKDCKVRLTEEIFKTE--
  70 SRTKKELrvk..IFL.GGS..E...G....TLNDCKIISVDEIFKIERP
  71 SRTKKELrvk..IFL.GGS..E...G....TLNDCKIISVDEIFKIERP
  72 -------.....---.---..-...-....-------------------
  73 -------.....---.---..-...-....-------------------
  74 -------.....---.---..-...-....-------------------
  75 -------.....---.---..-...-....-------------------