PFRMAT SS TARGET T0489 AUTHOR 4008-1775-0004 METHOD This file is the result of combining several RDB files, specifically METHOD T0489.t06.str2.rdb (weight 1.54425) METHOD T0489.t06.str4.rdb (weight 0.924988) METHOD T0489.t06.pb.rdb (weight 0.789901) METHOD T0489.t06.bys.rdb (weight 0.748322) METHOD T0489.t06.alpha.rdb (weight 0.678173) METHOD T0489.t04.str2.rdb (weight 1.54425) METHOD T0489.t04.str4.rdb (weight 0.924988) METHOD T0489.t04.pb.rdb (weight 0.789901) METHOD T0489.t04.bys.rdb (weight 0.748322) METHOD T0489.t04.alpha.rdb (weight 0.678173) METHOD T0489.t2k.str2.rdb (weight 1.54425) METHOD T0489.t2k.str4.rdb (weight 0.924988) METHOD T0489.t2k.pb.rdb (weight 0.789901) METHOD T0489.t2k.bys.rdb (weight 0.748322) METHOD T0489.t2k.alpha.rdb (weight 0.678173) METHOD These files were combined by translating their predictions into EHL METHOD predictions with tables generated by compare-real, and then combining METHOD those predictions with weights proportional to their mutual information METHOD with the EHL alphabet. The comments from the individual files follow. METHOD METHOD Comments from T0489.t06.str2.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t06-IDGaaH13-3-13-7-13-9-13-11-str2-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 13 (1 str2 ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t06-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 48.473 METHOD METHOD ============================================ METHOD Comments from T0489.t06.str4.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t06-IDGaaH13-3-13-7-13-9-13-11-str4-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 21 (1 str4 ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t06-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 48.473 METHOD METHOD ============================================ METHOD Comments from T0489.t06.pb.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t06-IDGaaH13-3-13-7-13-9-13-11-pb-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 16 (1 pb ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t06-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 48.473 METHOD METHOD ============================================ METHOD Comments from T0489.t06.bys.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t06-IDGaaH13-3-13-7-13-9-13-11-bys-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 11 (1 Bystroff ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t06-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 48.473 METHOD METHOD ============================================ METHOD Comments from T0489.t06.alpha.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t06-IDGaaH13-3-13-7-13-9-13-11-alpha-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 11 (1 ABCDEFGHIST ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t06-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 48.473 METHOD METHOD ============================================ METHOD Comments from T0489.t04.str2.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t04-IDGaaH13-3-13-7-13-9-13-11-str2-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 13 (1 str2 ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t04-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 48.6216 METHOD METHOD ============================================ METHOD Comments from T0489.t04.str4.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t04-IDGaaH13-3-13-7-13-9-13-11-str4-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 21 (1 str4 ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t04-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 48.6216 METHOD METHOD ============================================ METHOD Comments from T0489.t04.pb.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t04-IDGaaH13-3-13-7-13-9-13-11-pb-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 16 (1 pb ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t04-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 48.6216 METHOD METHOD ============================================ METHOD Comments from T0489.t04.bys.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t04-IDGaaH13-3-13-7-13-9-13-11-bys-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 11 (1 Bystroff ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t04-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 48.6216 METHOD METHOD ============================================ METHOD Comments from T0489.t04.alpha.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t04-IDGaaH13-3-13-7-13-9-13-11-alpha-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 11 (1 ABCDEFGHIST ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t04-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 48.6216 METHOD METHOD ============================================ METHOD Comments from T0489.t2k.str2.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t2k-IDGaaH13-3-13-7-13-9-13-11-str2-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 13 (1 str2 ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t2k-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 47.711 METHOD METHOD ============================================ METHOD Comments from T0489.t2k.str4.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t2k-IDGaaH13-3-13-7-13-9-13-11-str4-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 21 (1 str4 ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t2k-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 47.711 METHOD METHOD ============================================ METHOD Comments from T0489.t2k.pb.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t2k-IDGaaH13-3-13-7-13-9-13-11-pb-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 16 (1 pb ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t2k-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 47.711 METHOD METHOD ============================================ METHOD Comments from T0489.t2k.bys.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t2k-IDGaaH13-3-13-7-13-9-13-11-bys-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 11 (1 Bystroff ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t2k-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 47.711 METHOD METHOD ============================================ METHOD Comments from T0489.t2k.alpha.rdb METHOD ============================================ METHOD TARGET T0489 METHOD Using neural net dunbrack-40pc-3157-t2k-IDGaaH13-3-13-7-13-9-13-11-alpha-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 11 (1 ABCDEFGHIST ) METHOD The input amino acid frequencies were determined from METHOD alignment T0489.t2k-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 47.711 METHOD METHOD ============================================ MODEL 1 M C 0.45 M C 0.47 F C 0.48 K C 0.54 W C 0.61 P C 0.57 W C 0.48 K C 0.50 A C 0.49 D C 0.57 D C 0.57 E C 0.61 S C 0.65 G C 0.75 N C 0.72 A H 0.53 E H 0.52 M H 0.48 P H 0.78 W H 0.88 E H 0.91 Q H 0.90 A H 0.85 L H 0.77 A H 0.58 I C 0.46 P H 0.62 V H 0.69 L H 0.75 A H 0.65 H C 0.62 L C 0.73 S C 0.81 S H 0.65 T H 0.82 E H 0.89 Q H 0.91 H H 0.92 K H 0.92 L H 0.92 T H 0.92 Q H 0.92 M H 0.92 A H 0.92 A H 0.92 R H 0.92 F H 0.91 L H 0.88 Q H 0.81 Q H 0.66 K H 0.47 R C 0.48 L C 0.45 V E 0.44 A C 0.50 L C 0.56 Q C 0.71 G C 0.79 L C 0.55 E E 0.57 L E 0.48 T C 0.74 P H 0.60 L H 0.74 H H 0.87 Q H 0.89 A H 0.92 R H 0.92 I H 0.92 A H 0.92 M H 0.90 L H 0.88 F H 0.83 C H 0.76 L H 0.68 P H 0.72 V H 0.69 L H 0.57 E C 0.47 L C 0.61 G C 0.71 I C 0.45 E H 0.55 W H 0.50 L C 0.47 D C 0.68 G C 0.80 F C 0.66 H C 0.61 E E 0.70 V E 0.76 L E 0.79 I E 0.75 Y E 0.54 P C 0.68 A C 0.71 P C 0.58 F C 0.52 I C 0.47 V C 0.53 D C 0.60 D C 0.51 E C 0.45 W C 0.42 E C 0.44 D C 0.52 D C 0.49 I C 0.65 G C 0.67 L C 0.48 V E 0.53 H C 0.50 N C 0.49 Q C 0.49 R C 0.43 V E 0.48 V E 0.47 Q E 0.47 S C 0.45 G C 0.56 Q C 0.43 S C 0.38 W C 0.40 Q C 0.47 Q C 0.66 G C 0.66 P C 0.51 V E 0.75 V E 0.76 L E 0.75 N C 0.53 W C 0.45 L H 0.69 D H 0.74 I H 0.79 Q H 0.70 D H 0.54 S C 0.63 F C 0.67 D C 0.67 A C 0.59 S C 0.70 G C 0.76 F C 0.60 N E 0.42 L E 0.52 V E 0.51 V H 0.51 H H 0.63 E H 0.73 V H 0.79 A H 0.80 H H 0.80 K H 0.73 L H 0.58 D C 0.46 T H 0.55 R H 0.48 N C 0.69 G C 0.77 D C 0.64 R C 0.55 A C 0.65 S C 0.73 G C 0.73 V C 0.69 P C 0.64 L C 0.62 I C 0.70 P C 0.65 L C 0.51 R H 0.52 E H 0.55 V H 0.66 A H 0.73 G H 0.77 W H 0.86 E H 0.90 H H 0.91 D H 0.91 L H 0.91 H H 0.92 A H 0.92 A H 0.91 M H 0.91 N H 0.91 N H 0.89 I H 0.88 Q H 0.89 D H 0.90 E H 0.88 I H 0.87 D H 0.84 L H 0.70 V C 0.53 G C 0.68 E C 0.66 S C 0.65 A C 0.51 A C 0.50 S C 0.54 I C 0.53 D C 0.65 A H 0.58 Y H 0.50 A C 0.47 A C 0.48 T C 0.59 D C 0.76 P H 0.73 A H 0.78 E H 0.82 C H 0.86 F H 0.83 A H 0.81 V H 0.80 L H 0.74 S H 0.76 E H 0.78 Y H 0.72 F H 0.58 F H 0.51 S C 0.51 A C 0.64 P H 0.57 E H 0.74 L H 0.76 F H 0.68 A H 0.66 P H 0.74 R H 0.69 F H 0.75 P H 0.87 A H 0.91 L H 0.92 W H 0.92 Q H 0.92 R H 0.92 F H 0.92 C H 0.92 H H 0.91 F H 0.86 Y H 0.76 R H 0.63 Q H 0.50 D C 0.67 P H 0.68 L H 0.76 A H 0.82 R H 0.75 R H 0.69 R H 0.62 E H 0.59 N C 0.56 G C 0.67 L C 0.59 Q C 0.61 D C 0.67 E C 0.61 G C 0.71 D C 0.59 R C 0.48 R E 0.52 I E 0.60 V E 0.58 H C 0.58 END