a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0487 Argonaute protein silencing complex, Thermus thermophilus, 685 residues
- gi|166706858|ref|NP_001098067.2|_169:926 piwi protein [Bombyx mori]
- gi|166245168|dbj|BAF73717.2| argonaute 3 [Bombyx mori]
- gi|167860160|ref|NP_001108114.1|_169:926 AGO3 protein [Bombyx mori]
- gi|164605505|dbj|BAF98575.1| AGO3 [Bombyx mori]
- gi|126002279|ref|XP_001352313.1|_61:814 GA19370-PA [Drosophila pseudoobscura]
- gi|54640595|gb|EAL29401.1| GA19370-PA [Drosophila pseudoobscura]
- gi|46255097|ref|YP_006009.1|_2:685 hypothetical protein TT_P0026 [Thermus thermophilus HB27]
- gi|46197946|gb|AAS82356.1| hypothetical protein TT_P0026 [Thermus thermophilus HB27]
- gi|55978251|ref|YP_145307.1|_2:685 hypothetical protein TTHB068 [Thermus thermophilus HB8]
- gi|55773424|dbj|BAD71864.1| conserved hypothetical protein [Thermus thermophilus HB8]
- gi|190616925|gb|EDV32449.1|_115:868 GF14047 [Drosophila ananassae]
- gi|190661755|gb|EDV58947.1|_90:843 GG10337 [Drosophila erecta]
- gi|158299484|ref|XP_319604.4|_171:930 AGAP008862-PA [Anopheles gambiae str. PEST]
- gi|157013540|gb|EAA14901.5| AGAP008862-PA [Anopheles gambiae str. PEST]
- gi|156545187|ref|XP_001603582.1|_198:958 PREDICTED: similar to PIWI [Nasonia vitripennis]
- gi|126842396|gb|ABO27430.1|_122:867 Argonaute3 [Drosophila melanogaster]
- gi|81300343|ref|YP_400551.1|_6:722 hypothetical protein Synpcc7942_1534 [Synechococcus elongatus PCC 7942]
- gi|81169224|gb|ABB57564.1| conserved hypothetical protein [Synechococcus elongatus PCC 7942]
- gi|56752529|ref|YP_173230.1|_6:722 hypothetical protein syc2520_d [Synechococcus elongatus PCC 6301]
- gi|56687488|dbj|BAD80710.1| hypothetical protein [Synechococcus elongatus PCC 6301]
- gi|145533507|ref|XP_001452498.1|_29:747 hypothetical protein GSPATT00002500001 [Paramecium tetraurelia strain d4-2]
- gi|74830583|emb|CAI39075.1| PAZ and PIWI domain protein [Paramecium tetraurelia]
- gi|124420197|emb|CAK85101.1| unnamed protein product [Paramecium tetraurelia]
- gi|145509146|ref|XP_001440517.1|_30:748 hypothetical protein GSPATT00009468001 [Paramecium tetraurelia strain d4-2]
- gi|74830558|emb|CAI39070.1| PAZ and PIWI domain protein [Paramecium tetraurelia]
- gi|124407734|emb|CAK73120.1| unnamed protein product [Paramecium tetraurelia]
- gi|11386645|sp|Q9SJK3|AGOL_ARATH_284:965 Argonaute-like protein At2g27880 [Taxonomy]
- gi|4510428|gb|AAD21514.1| Argonaute (AGO1)-like protein [Arabidopsis thaliana]
- gi|30683679|ref|NP_850110.1|_284:965 argonaute protein, putative / AGO, putative [Arabidopsis thaliana]
- gi|22298491|ref|NP_681738.1|_31:744 hypothetical protein tll0948 [Thermosynechococcus elongatus BP-1]
- gi|22294671|dbj|BAC08500.1| tll0948 [Thermosynechococcus elongatus BP-1]
- gi|28209520|gb|AAO37538.1|_316:1023 putative argonaute protein [Oryza sativa (japonica cultivar-group)]
- gi|108711587|gb|ABF99382.1| Argonaute-like protein At2g27880, putative, expressed [Oryza sativa (japonica cultivar-group)]
- gi|157279696|dbj|BAF80153.1| ARGONAUTE family protein [Oryza sativa Japonica Group]
- gi|145535820|ref|XP_001453643.1|_30:748 hypothetical protein GSPATT00019939001 [Paramecium tetraurelia strain d4-2]
- gi|74830553|emb|CAI39069.1| PAZ and PIWI domain protein [Paramecium tetraurelia]
- gi|124421365|emb|CAK86246.1| unnamed protein product [Paramecium tetraurelia]
- gi|156554763|ref|XP_001605719.1|_29:781 PREDICTED: similar to aubergine [Nasonia vitripennis]
- gi|157346648|emb|CAO16717.1|_104:842 unnamed protein product [Vitis vinifera]
- gi|86606806|ref|YP_475569.1|_8:715 Piwi domain protein [Synechococcus sp. JA-3-3Ab]
- gi|86555348|gb|ABD00306.1| Piwi domain protein [Synechococcus sp. JA-3-3Ab]
- gi|73995329|ref|XP_543433.2|_492:1223 PREDICTED: similar to piwi like homolog 1 [Canis familiaris]
- gi|125546068|gb|EAY92207.1|_316:1020 hypothetical protein OsI_013440 [Oryza sativa (indica cultivar-group)]
- gi|86610170|ref|YP_478932.1|_7:729 Piwi domain protein [Synechococcus sp. JA-2-3B'a(2-13)]
- gi|86558712|gb|ABD03669.1| Piwi domain protein [Synechococcus sp. JA-2-3B'a(2-13)]
- gi|125588271|gb|EAZ28935.1|_281:989 hypothetical protein OsJ_012418 [Oryza sativa (japonica cultivar-group)]
- gi|115455965|ref|NP_001051583.1|_316:1024 Os03g0800200 [Oryza sativa (japonica cultivar-group)]
- gi|113550054|dbj|BAF13497.1| Os03g0800200 [Oryza sativa (japonica cultivar-group)]
- gi|18976909|ref|NP_578266.1|_84:770 hypothetical protein PF0537 [Pyrococcus furiosus DSM 3638]
- gi|18892524|gb|AAL80661.1| hypothetical protein [Pyrococcus furiosus DSM 3638]
- gi|62738878|pdb|1Z25|A_85:771 Chain A, Structure Of P.Furiosus Argonaute With Bound Mn2+ [Taxonomy]
- gi|62738879|pdb|1Z26|A Chain A, Structure Of Pyrococcus Furiosus Argonaute With Bound Tungstate [Taxonomy]
- gi|157357023|emb|CAO63250.1|_329:1036 unnamed protein product [Vitis vinifera]
- gi|27819513|gb|AAO24917.1|_135:776 putative argonaute protein [Oryza sativa (japonica cultivar-group)]
- gi|52695955|pdb|1U04|A_85:771 Chain A, Crystal Structure Of Full Length Argonaute From Pyrococcus Furiosus [Taxonomy]
- gi|30694320|ref|NP_849784.1|_336:1006 AGO1 (ARGONAUTE 1) [Arabidopsis thaliana]
- gi|169788718|dbj|BAG12806.1|_403:1062 argonaute1 [Daucus carota]
- gi|166364682|ref|YP_001656955.1|_7:746 hypothetical protein MAE_19410 [Microcystis aeruginosa NIES-843]
- gi|166087055|dbj|BAG01763.1| hypothetical protein [Microcystis aeruginosa NIES-843]
- gi|159027320|emb|CAO86862.1|_8:746 unnamed protein product [Microcystis aeruginosa PCC 7806]
- gi|15221177|ref|NP_175274.1|_348:1004 AGO1 (ARGONAUTE 1) [Arabidopsis thaliana]
- gi|11386626|sp|O04379|AGO1_ARATH Protein argonaute [Taxonomy]
- gi|5733867|gb|AAD49755.1|AC007932_3 Identical to Argonaute protein from Arabidopsis thaliana gb|U91995. EST gb|AA720232 comes from this gene [Taxonomy]
- gi|2149640|gb|AAC18440.1| Argonaute protein [Arabidopsis thaliana]
- gi|24030354|gb|AAN41341.1| putative leaf development protein Argonaute [Arabidopsis thaliana]
- gi|108711472|gb|ABF99267.1|_135:776 Piwi domain containing protein, expressed [Oryza sativa (japonica cultivar-group)]
- gi|125588191|gb|EAZ28855.1| hypothetical protein OsJ_012338 [Oryza sativa (japonica cultivar-group)]
- gi|164686207|ref|ZP_02210237.1|_6:733 hypothetical protein CLOBAR_02645 [Clostridium bartlettii DSM 16795]
- gi|164601809|gb|EDQ95274.1| hypothetical protein CLOBAR_02645 [Clostridium bartlettii DSM 16795]
- gi|119351181|gb|ABL63483.1|_368:1023 argonaute 2 [Pisum sativum]
- gi|125545984|gb|EAY92123.1|_281:955 hypothetical protein OsI_013356 [Oryza sativa (indica cultivar-group)]
- gi|15606619|ref|NP_213999.1|_25:705 hypothetical protein aq_1447 [Aquifex aeolicus VF5]
- gi|118137724|pdb|2F8S|A Chain A, Crystal Structure Of Aa-Ago With Externally-Bound Sirna [Taxonomy]
- gi|118137725|pdb|2F8S|B Chain B, Crystal Structure Of Aa-Ago With Externally-Bound Sirna [Taxonomy]
- gi|118137728|pdb|2F8T|A Chain A, Crystal Structure Of Aa-Ago With Externally-Bound Sirna [Taxonomy]
- gi|118137729|pdb|2F8T|B Chain B, Crystal Structure Of Aa-Ago With Externally-Bound Sirna [Taxonomy]
- gi|126031218|pdb|2NUB|A Chain A, Structure Of Aquifex Aeolicus Argonuate [Taxonomy]
- gi|2983852|gb|AAC07406.1| hypothetical protein aq_1447 [Aquifex aeolicus VF5]
- gi|75765647|pdb|1YVU|A_25:705 Chain A, Crystal Structure Of A. Aeolicus Argonaute [Taxonomy]
- gi|6630673|dbj|BAA88525.1|_4:756 PAP [Paramecium caudatum]
- gi|25005466|dbj|BAC23150.1| aubergine/piwi homologue [Paramecium caudatum]
- gi|119493538|ref|ZP_01624204.1|_9:763 hypothetical protein L8106_18222 [Lyngbya sp. PCC 8106]
- gi|119452655|gb|EAW33836.1| hypothetical protein L8106_18222 [Lyngbya sp. PCC 8106]
- gi|170077638|ref|YP_001734276.1|_4:615 conserved hypothetical protein containing Piwi domain [Synechococcus sp. PCC 7002]
- gi|169885307|gb|ACA99020.1| conserved hypothetical protein containing Piwi domain [Synechococcus sp. PCC 7002]
- gi|56478414|ref|YP_160003.1|_3:727 hypothetical protein containing the PIWI domain [Azoarcus sp. EbN1]
- gi|56314457|emb|CAI09102.1| hypothetical protein containing the PIWI domain [Azoarcus sp. EbN1]
- gi|166706854|ref|NP_001036995.2|_314:1009 argonaute 2 [Bombyx mori]
- gi|166245166|dbj|BAD91160.2| argonaute 2 [Bombyx mori]
- gi|187604166|ref|ZP_02990376.1|_6:595 stem cell self-renewal protein Piwi domain protein [Exiguobacterium sp. AT1b]
- gi|187483715|gb|EDU21709.1| stem cell self-renewal protein Piwi domain protein [Exiguobacterium sp. AT1b]
- gi|15669511|ref|NP_248321.1|_120:713 hypothetical protein MJ1321 [Methanocaldococcus jannaschii DSM 2661]
- gi|37999509|sp|Q58717|Y1321_METJA Uncharacterized protein MJ1321 [Taxonomy]
- gi|1591961|gb|AAB99334.1| hypothetical protein MJ_1321 [Methanocaldococcus jannaschii DSM 2661]
- gi|182676905|ref|YP_001831052.1|_27:484 conserved hypothetical protein [Beijerinckia indica subsp. indica ATCC 9039]
- gi|182636535|gb|ACB97308.1| conserved hypothetical protein [Beijerinckia indica subsp. indica ATCC 9039]
- gi|170116966|ref|XP_001889672.1|_281:920 argonaute-like protein [Laccaria bicolor S238N-H82]
- gi|164635387|gb|EDQ99695.1| argonaute-like protein [Laccaria bicolor S238N-H82]
- gi|154244391|ref|YP_001415349.1|_22:479 hypothetical protein Xaut_0434 [Xanthobacter autotrophicus Py2]
- gi|154158476|gb|ABS65692.1| conserved hypothetical protein [Xanthobacter autotrophicus Py2]
- gi|13475183|ref|NP_106747.1|_48:499 hypothetical protein mlr6204 [Mesorhizobium loti MAFF303099]
- gi|14025934|dbj|BAB52533.1| mlr6204 [Mesorhizobium loti MAFF303099]
- gi|83954752|ref|ZP_00963463.1|_25:478 hypothetical protein NAS141_16063 [Sulfitobacter sp. NAS-14.1]
- gi|83841036|gb|EAP80207.1| hypothetical protein NAS141_16063 [Sulfitobacter sp. NAS-14.1]
- gi|84686687|ref|ZP_01014579.1|_28:490 hypothetical protein RB2654_00595 [Rhodobacterales bacterium HTCC2654]
- gi|84665361|gb|EAQ11839.1| hypothetical protein RB2654_00595 [Rhodobacterales bacterium HTCC2654]
- gi|84701997|ref|ZP_01016572.1|_20:475 Piwi domain protein [Parvularcula bermudensis HTCC2503]
- gi|84691243|gb|EAQ17083.1| Piwi domain protein [Parvularcula bermudensis HTCC2503]
- gi|94311099|ref|YP_584309.1|_24:482 hypothetical protein Rmet_2161 [Ralstonia metallidurans CH34]
- gi|93354951|gb|ABF09040.1| conserved hypothetical protein [Ralstonia metallidurans CH34]
- gi|145607894|ref|XP_365158.2|_408:1001 hypothetical protein MGG_13617 [Magnaporthe grisea 70-15]
- gi|145015372|gb|EDJ99908.1| hypothetical protein MGG_13617 [Magnaporthe grisea 70-15]
- gi|154490797|ref|ZP_02030738.1|_12:606 hypothetical protein PARMER_00714 [Parabacteroides merdae ATCC 43184]
- gi|154088545|gb|EDN87589.1| hypothetical protein PARMER_00714 [Parabacteroides merdae ATCC 43184]
- gi|167754324|ref|ZP_02426451.1|_199:609 hypothetical protein ALIPUT_02617 [Alistipes putredinis DSM 17216]
- gi|167658949|gb|EDS03079.1| hypothetical protein ALIPUT_02617 [Alistipes putredinis DSM 17216]
- gi|148266051|ref|YP_001232757.1|_132:472 hypothetical protein Gura_4040 [Geobacter uraniireducens Rf4]
- gi|146399551|gb|ABQ28184.1| hypothetical protein Gura_4040 [Geobacter uraniireducens Rf4]
- gi|146337912|ref|YP_001202960.1|_132:471 Conserved hypothetical protein; putative Piwi domain [Bradyrhizobium sp. ORS278]
- gi|146190718|emb|CAL74723.1| Conserved hypothetical protein; putative Piwi domain [Bradyrhizobium sp. ORS278]
- gi|68480922|ref|XP_715614.1|_35:628 argonaute-like protein fragment [Candida albicans SC5314]
- gi|68481033|ref|XP_715558.1| argonaute-like protein fragment [Candida albicans SC5314]
- gi|46437185|gb|EAK96536.1| argonaute-like protein fragment [Candida albicans SC5314]
- gi|46437245|gb|EAK96595.1| argonaute-like protein fragment [Candida albicans SC5314]
- gi|149237134|ref|XP_001524444.1|_97:437 hypothetical protein LELG_04416 [Lodderomyces elongisporus NRRL YB-4239]
- gi|146451979|gb|EDK46235.1| hypothetical protein LELG_04416 [Lodderomyces elongisporus NRRL YB-4239]
- gi|188992493|ref|YP_001904503.1|_159:481 putative regulatory protein [Xanthomonas campestris pv. campestris]
- gi|167734253|emb|CAP52463.1| putative regulatory protein [Xanthomonas campestris pv. campestris]
- gi|20089856|ref|NP_615931.1|_128:466 hypothetical protein MA0979 [Methanosarcina acetivorans C2A]
- gi|19914805|gb|AAM04411.1| conserved hypothetical protein [Methanosarcina acetivorans C2A]
- gi|21225132|ref|NP_630911.1|_337:667 hypothetical protein SCO6840 [Streptomyces coelicolor A3(2)]
- gi|6900909|emb|CAB71853.1| hypothetical protein SC3D9.08c [Streptomyces coelicolor A3(2)]
- gi|73748042|ref|YP_307281.1|_152:764 hypothetical protein cbdb_A102 [Dehalococcoides sp. CBDB1]
- gi|73659758|emb|CAI82365.1| hypothetical protein [Dehalococcoides sp. CBDB1]

              10        20        30             40          50        
              |         |         |              |           |        
   1 MNHLGKTEVFLNRFALRPLNPEELRPWRLEVV.....LDPPPGREEV.YP.LLAQVARRAGGVTV
   2 -KGETGVPIEVTCNYI-YLNFKENIVFEYEVK.....FEPDQDYKHL.RF.KLLNEHIEHFKEKT
   3 -KGETGVPIEVTCNYI-YLNFKENIVFEYEVK.....FEPDQDYKHL.RF.KLLNEHIEYFKEKT
   4 -QGKEGEPISLQSNFFRLQTKPEWRIVHYHVD.....FEPELENIRV.RM.GILSNHANILGAGY
   5 -NHLGKTEVFLNRFALRPLNPEELRPWRLEVV.....LDPPPGREEV.YP.LLAQVARRAGGVTV
   6 -NHLGKTEVFLNRFALRPLNPEELRPWRLEVV.....LDPPPGREEV.YP.LLAQVARRAGGVTV
   7 -KGSDGVPIRLQSNFFRLKTVPEWRIVHYHVE.....FEPPIENIRV.RM.GILSDQSKFLGAGY
   8 -KGTDGVPVMLQTNFFRLKTKPEWRIVHYHVE.....FEPSIENPRV.RM.GVLSNHANFLGSGY
   9 --GKEGNPLHLMGNFMELKCEPDRGIFLYTVD.....FSPPIDAKRT.RQrCIDSHKDVFGTAYT
  10 -QGSSGKTISLTANYINLKVNKDKGMFQYEVK.....FAPDVDSRSL.RYkLLNQHLNDLGNVKT
  11 --GSKGSSVNIYCNYLKLTTDESKGVFNYEVR.....FFPPIDSVHLrIK.YLNDHKDKLGGTKT
  12 --NLRRSSIVLNRFYVKSLSQSDLTAYEYRCI.....FKKTPELGDE.KR.LLASICYKLGAIAV
  13 --NLRRSSIVLNRFYVKSLSQSDLTAYEYRCI.....FKKTPELGDE.KR.LLASICYKLGAIAV
  14 -------------------------IFQPTIT.....PEQQISKWRD.IF.KAAKTGLQENLKVF
  15 --------------------------FQPFLS.....PEQQISKWRD.IF.KIAKSGLQENLKVF
  16 --------------------------------.....----------.--.--------------
  17 --------------------------------.....----------.--.--------------
  18 ---FQEVEVILNRFFVKKLSRPDLTFHEYQCQ.....FTQVPEQGSE.QK.AISSVCYKLGVTAV
  19 --------------------------------.....----------.--.--------------
  20 --------------------------FQPFLS.....PEQQIAKWRE.IF.KVAKAGLQENLKVF
  21 -LGTTGRKVVLNANYFKLKSKTDWCLYQYRVD.....IAPDEERTIV.RK.SLLRTHKAALGAYL
  22 --------------------------------.....----------.--.--VKLVKTDDGAGP
  23 ----QEVPVILNRFLVKELTQEDLTFYEYDCR.....PNPPPELGEE.QR.AIARVCNRLDVIAA
  24 --GTLGRPVKLFTNHFRVTSRPQQVTYKYNID.....YLPDIEDGKV.RSeLLLQHKAFIGECHI
  25 --------------------------------.....----------.--.--------------
  26 -----KVEVTLNRFFVKELTQEELTFYEYSCR.....PNPLPDLGEE.QR.ALSKICNQLGVMAV
  27 --------------------------------.....----------.--.--------------
  28 --------------------------------.....----------.--.--------------
  29 -RNDYQSKLVLRLLKENGIGEYELSKLLRKFR.....KPKTFGDYKV.IP.SVEMSVIKHDEDFY
  30 -RNDYQSKLVLRLLKENGIGEYELSKLLRKFR.....KPKTFGDYKV.IP.SVEMSVIKHDEDFY
  31 --------------------------------.....----------.--.--------------
  32 --------------------------------.....----------.--.--------------
  33 -RNDYQSKLVLRLLKENGIGEYELSKLLRKFR.....KPKTFGDYKV.IP.SVEXSVIKHDEDFY
  34 --------------------------------.....----------.--.--------------
  35 --------------------------------.....----------.--.--------------
  36 --NTANSPIFLSEISSLTLKNSCLNCFQLNHQ.....VTRKIGNRFS.WQ.FSRKFPDVV--VIF
  37 ---TANSPIFLSEISSLTLNNNCLNCFKLNHQ.....VTRKIGNRFS.WQ.FSRKFPAVV--VIF
  38 --------------------------------.....----------.--.--------------
  39 --------------------------------.....----------.--.--------------
  40 ------REFNVITEFKNELKPEDIKIFLYSMP.....IKDINERHSE.NY.AIVQELKKINENPN
  41 --------------------------------.....----------.--.--------------
  42 --------------------------------.....----------.--.--------------
  43 -------------------------------K.....PTHEIQKEKL.NK.VRWRVFLQTGLPTF
  44 -------------------------------K.....PTHEIQKEKL.NK.VRWRVFLQTGLPTF
  45 --------VMVRSNFHELQFSPEKPIYEYILEmn8elIDEALKNYRQ.QL.QQELILYMNINQHI
  46 -QNSTSSSIYLSEIFPLTILKPNLICFRLTPE.....VDREVGNRLS.WR.FSQKFAEIV--VIW
  47 --------------------------------.....----------.--.--------------
  48 -------------------------VYYYRLT.....FDDDHEDINP.TQ.LTRRGARMLSGANG
  49 --------------------------------.....----------.--.--------------
  50 --------------------------------.....----------.--.--------------
  51 --------------------------------.....----------.--.--------------
  52 --------------------------------.....----------.--.--------------
  53 --------------------------------.....----------.--.--------------
  54 --------------------------------.....----------.--.--------------
  55 --------------------------------.....----------.--.--------------
  56 --------------------------------.....----------.--.--------------
  57 --------------------------------.....----------.--.--------------
  58 --------------------------------.....----------.--.--------------
  59 --------------------------------.....----------.--.--------------
  60 --------------------------------.....----------.--.--------------
  61 --------------------------------.....----------.--.--------------
  62 --------------------------------.....----------.--.--------------
  63 --------------------------------.....----------.--.--------------
  64 --------------------------------.....----------.--.--------------
  65 --------------------------------.....----------.--.--------------
  66 --------------------------------.....----------.--.--------------
  67 --------------------------------.....----------.--.--------------
  68 --------------------------------.....----------.--.--------------
  69 --------------------------------.....----------.--.--------------
  70 --------------------------------.....----------.--.--------------


      60        70        80        90       100             110       
      |         |         |         |         |               |       
   1 RMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD.PGE.....RSVLSALARRLL
   2 FDGTTLYVPHELPDAVRNLVSTNPYDQSKVNVSIIFRRTRRLSE.--M.....IHIYNVMFKCIM
   3 FDGTTLYVPHELPDAVRNLVSTNPYDQSKVNVSIIFRRTRRLSE.--M.....IHIYNVMFKCIM
   4 LFDGKQLFTHKKLEKDSIVLCGQSKMGTDYKISIKCVGIVSNAE.PRF.....LQVLNLILRRSM
   5 RMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD.PGE.....RSVLSALARRLL
   6 RMGDGLASWSPPEVLVLEGTLARMGQNYAYRLYPKGRRPLDPKD.PGE.....RSVLSALARRLL
   7 LFDGMQLFSVRKYPQDLTVLRVKSKLGTDYTITIKFVGFISTSE.TRF.....LQVLNLILRRSM
   8 LFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISIKFVGFISCAE.PRF.....LQVLNLILRRSM
   9 FDGHILLLPKALEQERFKLTSQHPTEGTPVTLSVVFRVQQQMSQ.N--.....VAFYNKLFRRIM
  10 FDGTVLYLPIKLPNNRQTYESVHPLDNSIVTLTV--IFQKKQAM.TQN.....IAFFNNLMNRVM
  11 FDGNTLYLPILLPNKMTVFIS----KAEDVELQIRILYKKKEEM.RNC.....TQLYNILFDRVM
  12 RIGSNIITKEAVRPEKLQGHDWQLVQMGTKQLDCRNDAHRCALE.TFE.....RKFLERDLSASS
  13 RIGSNIITKEAVRPEKLQGHDWQLVQMGTKQLDCRNDAHRCALE.TFE.....RKFLERDLSASS
  14 ITNNQILYSPVRAQTMGLILGIYEEEGTSYTISIEEKAVLKPGE.PEY.....TGLIGRFFKMLL
  15 ITNNQILYSPVRAQTMGLLLGVYEEEGTSYSISIEEKAVLKPGE.PEY.....TGLIGRFFKMLL
  16 ------------------------------TIQVLDVVLRDKPS.NDY.....VSVGRSFFHTSL
  17 ------------------------------TIQVLDVVLRDKPS.NDY.....VSVGRSFFHTSL
  18 RLGSCIITREPIDPERMRTKDWQLQLIGCRELSCQNYRERQALE.TFE.....RKILEEKLKETF
  19 ---------------TDLYHLQQFLLGRQRDMPQETIQVLDVVL.RES.....PSWNYVTVSRSF
  20 ITNNQILYSPVRAQTMGLLLGVFEEEGTSHSISIEEKAVLKPGE.PEY.....TGLIGRFFKMLL
  21 FDGTVLYTSNRLPN-PMELNSIRQEDKKPMSIKIRLVGDVVKGD.YHY.....FQFFNIMVRKCL
  22 RREREFKVAIKLASKGDLYQLQQFLCGRQLSAPQETIQILDVVL.RAS.....PSEKYTVVGRSF
  23 RLGSRIITQERVSPSQLKTPEWELEERGLRVLTCANAQERSALE.SFE.....RKRIGLRLKSQY
  24 FDGSSLLLPHKL--LLPKTELVSLLKNQVVKLTIEFISELSPNS.PDC.....LRYYNILFRRIL
  25 ---------------TDLYHLQQFLLGRQRDMPQETIQVLDVVL.RES.....PSWNYVTVSRSF
  26 RLGNRIITREKVPASKLKTEEWELEELGSKALDCTDPTERQALE.TFE.....RKKLDWSLRSKY
  27 ---------------TDLYHLQQFLLGRQRDMPQETIQVLDVVL.RES.....PSWNYVTVSRSF
  28 ---------------TDLYHLQQFLLGRQRDMPQETIQVLDVVL.RES.....PSWNYVTVSRSF
  29 LVIHIIHQIQSMKTLWELVNKDPKELEEFLMTHKENLMLKDIAS.PLK.....TVYKPCFEEYTK
  30 LVIHIIHQIQSMKTLWELVNKDPKELEEFLMTHKENLMLKDIAS.PLK.....TVYKPCFEEYTK
  31 ----------------DLHHLGLFLQGRQADAPQEALQVLDIVL.REL.....PTTRYCPVGRSF
  32 --------------------------------------------.---.....-----------Q
  33 LVIHIIHQIQSXKTLWELVNKDPKELEEFLXTHKENLXLKDIAS.PLK.....TVYKPCFEEYTK
  34 --------------------------------------------.---.....------------
  35 --------------------------------------------.---.....------------
  36 EDNCFWVLAKDEKSIPSLQQWKEALSDIQEVLREDIGDHYYSIH.WLK.....DFQITALVTAQL
  37 EDNCFWVLAKDEKLLPSPQQWKEALSDIQEVLREDIGDHYYSIH.WLK.....DFQITALVTAQL
  38 --------------------------------------------.---.....------------
  39 --------------------------------------------.---.....-----------Q
  40 IVFNEYIIASFNPIINWGKYKDIDVKPDNRNINLDNSTERKILErLLL.....CDIKNNINNNTT
  41 -------------------------------------QGLDIVL.REL.....PTSRYCPVGRSF
  42 --------------------------------------------.---.....-------VSRSF
  43 RREDEFWCAGKVEKDTLYLTLSNGEIVELKRVGEEEFRGFQNER.ECQ.....ELFRDFLTKTKV
  44 RREDEFWCAGKVEKDTLYLTLSNGEIVELKRVGEEEFRGFQNER.ECQ.....ELFRDFLTKTKV
  45 YSPHLIQGDDIQKGKLLGLIDGQMENESTAQVFLKLVGRIKEGD.LSR.....QQIISRLIKQVL
  46 ENKYFWVLAKPTQKMPSPEQWRQALGEILEQLKEDIGDHYYSIQ.WVR.....DPQVTASTLAQL
  47 --------------------------------------------.---.....------------
  48 WCAVTDGEPLRVLSLRPLKVLRHEWNGMCCTASDETAGTLKSAN.PSE.....REAIQRLLNQCL
  49 --------------------KDMNGKDMPFEVSFKASGIVDYNN.VLKh12apTDTIQCIDIVLK
  50 --------------------------------------------.---.....------------
  51 --------------------------------------------.---.....-------IKNIR
  52 --------------------------------------------.---.....------------
  53 ------------ADKVSLGAGVEGWQGFFMSVRPSFKQLMVNVN.VCM.....TAFIQPGNLADR
  54 --------------------------------------------.---.....------------
  55 --------------------------------------------.---.....------------
  56 --------------------------------------------.---.....------------
  57 --------------------------------------------.---.....------------
  58 --------------------------------------------.---.....------------
  59 --------------------------------------------.---.....------------
  60 --------------------------------------------.---.....------------
  61 --------------------------------------------.---.....------------
  62 --------------------------------------------.---.....------------
  63 --------------------------------------------.---.....------------
  64 --------------------------------------------.---.....------------
  65 --------------------------------------------.---.....------------
  66 --------------------------------------------.---.....------------
  67 --------------------------------------------.---.....------------
  68 --------------------------------------------.---.....------------
  69 --------------------------------------------.---.....------------
  70 --------------------------------------------.---.....------------


        120               130            140       150       160       
         |                 |              |         |         |       
   1 ..QERLRR..LE.....GVW.VEGLAVYRRE.....HARGPGWRVLGGAVLDLWVSDS.GAFL..
   2 ..--KDLK..LI.....RFG.RQHYNEHAAI.....QIPQHKLEVWPGYVTAVDEY-E.GGLM..
   3 ..--KDLK..LI.....RFG.RQHYNEHAAI.....QIPQHKLEVWPGYVTAVDEY-E.GGLM..
   4 ..--KGLK..LE.....LVG.RNLFDPHAKI.....PIRDHQMELWPGYETSIRQH-E.KDIM..
   5 ..QERLRR..LE.....GVW.VEGLAVYRRE.....HARGPGWRVLGGAVLDLWVSDS.GAFL..
   6 ..QERLRR..LE.....GVW.VEGLAVYRRE.....HARGPGWRVLGGAVLDLWVSDS.GAFL..
   7 ..--KGLK..LE.....LVG.RNLFDPHAKI.....SIREFQMELWPGYETSIRQH-E.KDIL..
   8 ..--KGLK..LE.....LVG.RNLFDPRAKI.....EIREFKMELWPGYETSIRQH-E.KDIL..
   9 ..--YMLQ..LS.....EMG.RKHFDPTQAR.....IIPQHKLEIWPGFVTAVNEF-E.GGLM..
  10 ..--KALT..LV.....KIG.RHDFNPTCAH.....QIPQHRLEVWPGYVTAINEL-E.GGLK..
  11 ..--KVLN..YV.....KFD.RKQFDPSRPK.....IIPLAKLEVWPGYVTAVDEY-K.GGLM..
  12 ..QTEVRKa.AE.....GGL.IWWVVGAKGI.....EKSGNGWEVHRGRRIDVSLDAE.GNLY..
  13 ..QTEVRKa.AE.....GGL.IWWVVGAKGI.....EKSGNGWEVHRGRRIDVSLDAE.GNLY..
  14 ..--KQQK..LL.....QIG.RKYFNTKNLI.....NFDQFGLKVLPGVTCSLIKQEElGKYY..
  15 ..--KQQK..LL.....QIG.RKYFNTKNLI.....NFDQFGLKVLPGVSCSLIKQEEqGKYY..
  16 ..GKDARD..GR.....GEL.GDGIEYWRGY.....FQSLRLTQMGLSLNIDVSARSF.YEPI..
  17 ..GKDARD..GR.....GEL.GDGIEYWRGY.....FQSLRLTQMGLSLNIDVSARSF.YEPI..
  18 ..KKTIIEkdYE.....LGL.IWWISGEEGL.....EKTGHGWEVHRGRQIDLKIETD.EKLY..
  19 ..FSTQFG..HR.....GDI.GEGLECWRGY.....YQSLRPTQMGLSLNIDISATSF.FKPV..
  20 ..--KQQK..LL.....QIG.RKYFNTKNLI.....NFDQFGLKVLPGVSCSLIKQEEqGKYY..
  21 ..--ENLN..LQ.....LVG.RNYFDAAAKV.....EITQYRLELWPGYVTSIRQH-E.RDVL..
  22 ..FSTQLG..RK.....GEL.GDGLEYWRGY.....YQSLRPTQMGLSFNIDVSARSF.YESI..
  23 ..KKTEVE..WI.....GGGlLWWVTAQKGV.....ELSGEGWEIHRGRMIDVAVEPD.GKLY..
  24 ..--KQMN..LK.....QVG.RNYYNKQEAT.....EFFDHKLVIWPGYVTSILEY-E.TSIT..
  25 ..FSTQFG..HR.....GDI.GEGLECWRGY.....YQSLRPTQMGLSLNIDISATSF.FKPV..
  26 ..KRTEIE..RStg...GGL.IWWVTGLEGVe10vkPLCGDGWEVHRGRELDVVIRQD.KKLY..
  27 ..FSTQFG..HR.....GDI.GEGLECWRGY.....YQSLRPTQMGLSLNIDISATSF.FKPV..
  28 ..FSTQFG..HR.....GDI.GEGLECWRGY.....YQSLRPTQMGLSLNIDISATSF.FKPV..
  29 ..KPKLDH..NQ.....EIV.KYWYNYHIER.....YWNTPEAKLEFYRKFGQVDLKQ.PAILak
  30 ..KPKLDH..NQ.....EIV.KYWYNYHIER.....YWNTPEAKLEFYRKFGQVDLKQ.PAILak
  31 ..YSPDLG..RR.....QPL.GEGLESWRGF.....YQSIRPTQMGLSLNIDMSSTAF.IEPL..
  32 ..ETIQFG..HR.....GDI.GEGLECWRGY.....YQSLRPTQMGLSLNIDISATSF.FKPV..
  33 ..KPKLDH..NQ.....EIV.KYWYNYHIER.....YWNTPEAKLEFYRKFGQVDLKQ.PAILak
  34 ..------..-I.....PVG.RSFYSPDIGKk....QSLGDGLESWRGFYQSIRPT-Q.MGLS..
  35 ..YDPAIG..SK.....YPL.GDGLESWRGF.....YQSIRPTQMGLSLNIDMSSTAF.IEPL..
  36 ..AVRILK..IF.....GKF.SDPIVFPKDS.....QISENQVQVRREVNFWAEIIND.TDPA..
  37 ..AVRILK..IF.....GKF.SYPIVFPKDS.....QISENQVQVRREVNFWAEIIND.TDPA..
  38 ..------..-K.....QS-.----------.....--LGDGLESWRGFYQSIRPT-Q.MGLS..
  39 ..ETIQFG..HR.....GDI.GEGLECWRGY.....YQSLRPTQMGLSLNIDISATSF.FKPV..
  40 ..WAQQNK..YE.....IRG.NANPAVYLRK.....PIYLNDNLIIRRKLNFDVNIDK.KDII..
  41 ..YSPLLG..IR.....QPL.GEGLESWRGF.....YQSIRPTQNGLSLNIDMSSTAF.IEPL..
  42 ..FSTQFG..HR.....GDI.GEGLECWRGY.....YQSLRPTQMGLSLNIDISATSF.FK--..
  43 ..---KDK..FI.....SDF.YKKFRDKITV.....QGKNRKIALIPEVNEKVLKSEE.GYFL..
  44 ..---KDK..FI.....SDF.YKKFRDKITV.....QGKNRKIALIPEVNEKVLKSEE.GYFL..
  45 rnQMSMVS..VG.....RKG.NKLFWDKRSQ.....QCSYQNLEIWPGMECIFRSK-N.NQCT..
  46 ..AVRVLK..IR.....KPF.SPDIIFSENQ.....VQVQSEVDFWPETIELANTL--.-TPA..
  47 ..------..--.....---.--WQKTEADI.....RSDVSGWEIYRGFKLDIFVSSQ.GNVF..
  48 ..MQGARK..LAy15gnLVR.LTACQPSERV.....SAGGDYLDAFQSVTLIPDVLPD.GTAL..
  49 ..QGTLES..YV.....KAG.RQYFMRPASP.....IDLGDGLEMWTGLFQSAIFT--.SKAF..
  50 ..ERLAHP..NY.....MMN.RGKFRSKQAH.....PKSTSGLLIYPALDLNVNVSET.AEIV..
  51 ..KHKVVE..NI.....---.----------.....-------K-VESYCEYEVKKHD.GDYY..
  52 ..------..--.....---.----------.....----------------------.----..
  53 ..------..--.....---.----------.....----------------------.----..
  54 ..------..--.....---.----------.....----------------------.----..
  55 ..------..--.....---.----------.....----------------------.----..
  56 ..------..--.....---.----------.....----------------------.----..
  57 ..------..--.....---.----------.....----------------------.----..
  58 ..------..--.....---.----------.....----------------------.----..
  59 ..------..--.....---.----------.....----------------------.----..
  60 ..------..--.....---.----------.....----------------------.----..
  61 ..------..--.....---.-------KDI.....YANKNNVTIHEAIECGLSFVQQ.KKYV..
  62 ..------..--.....---.----------.....----------------------.----..
  63 ..------..--.....---.----------.....----------------------.----..
  64 ..------..--.....---.----------.....----------------------.----..
  65 ..------..--.....---.----------.....----------------------.----..
  66 ..------..--.....---.----------.....----------------------.----..
  67 ..------..--.....---.----------.....----------------------.----..
  68 ..------..--.....---.----------.....----------------------.----..
  69 ..------..--.....---.----------.....----------------------.----..
  70 ..------..--.....---.----------.....---------YRGFSVRVVPIEG.GKLG..


            170             180                 190           200      
             |               |                   |             |      
   1 ...LEVDPAYRILC.EMS.....LE.....AWLAQ.....GHPLPKRVRNAYD.R...RTWELLR
   2 ...LTLDSTHRVLR.TQT.....VL.....SLIKEv14mtDILIGASVMTTYN.K...KLFRVDT
   3 ...LTLDSTHRVLR.TQT.....VL.....SLIKEv14mtDILIGASVMTTYN.K...KLFRVDT
   4 ...LCAEITHKVMR.TET.....VY.....EILKRc13frANVLDLVVLTDYN.N...KTYRIND
   5 ...LEVDPAYRILC.EMS.....LE.....AWLAQ.....GHPLPKRVRNAYD.R...RTWELLR
   6 ...LEVDPAYRILC.EMS.....LE.....AWLAQ.....GHPLPKRVRNAYD.R...RTWELLR
   7 ...LCTEITHKVMR.TET.....VY.....DILRRc13frMNVLDMIVLTDYN.N...KTYRIND
   8 ...LGTEITHKVMR.TET.....VY.....DIMRRc13vrVNVLDLIVLTDYN.N...KTYRIND
   9 ...LNLDVTHRVLM.QTT.....VY.....THIKMl14vlKSLLGAVVLTRYN.K...KTYRIDD
  10 ...LNLDATHRVMR.LDT.....VR.....DLMTDm14vaNEIIGTSVLTRYN.N...RTYKIDD
  11 ...LCCDVSHRILC.QKT.....VL.....EMLVDl14arKMLVGNIVLTRYN.N...RTYKIND
  12 ...LEIDIHHRFYT.PWT.....VH.....QWLEQyp6plSYVRNNYLDERHG.F...INWQYGR
  13 ...LEIDIHHRFYT.PWT.....VH.....QWLEQyp6plSYVRNNYLDERHG.F...INWQYGR
  14 ...INIDSSFKMLR.CTT.....MY.....EELRNsrdy.SLIEGAIIMTVYN.Y...KFYRVNK
  15 ...INIDSSFKMLR.STT.....MY.....EELRNsrdf.SQLEGAIVMTVYN.Y...KFYKVNK
  16 ...VVTDFISKFLN.IRD.....LN.....RPLRDsd9kvLRTLKVKLLHWNC.T...KSAKISG
  17 ...VVTDFISKFLN.IRD.....LN.....RPLRDsd9kvLRTLKVKLLHWNG.T...KSAKISG
  18 ...LEIDIHHRFYT.PFK.....LE.....WWLSEyp...NIQIKYVRNTYKD.K...KKWILEN
  19 ...TVIQFVEEFLN.IRD.....TS.....RPLSDrd7ikKALRGVRIETNHQ.EdqiRRYKITG
  20 ...INIDSSFKMLR.STT.....MY.....EELRNsrdf.SQLEGAIIMTVYN.Y...KFYKVNK
  21 ...MCAEISHKVMR.NQT.....VY.....DILRDt14fsSTVIGSVVLTDYN.N...RTYKVDD
  22 ...LVTDFVAKHLK.LRD.....VS.....RALSDqd9kaLKGVKVQLTHREF.A...KRYKIAG
  23 ...LEVDIHYRFYT.PWT.....LH.....EWLESyp6piEIVRNTYFDANGK.R...LTWKYLG
  24 ...LCADVNHKLLR.MQT.....AY.....DLITGl15vsKELIGSIVFTLYN.N...KTYRVDA
  25 ...TVIQFVEEFLN.IRD.....TS.....RPLSDrd7ikKALRGVRIETNHQ.EdqiRRYKITG
  26 ...LEIDIRYHFYS.PWT.....LH.....EWLENyp6siEIVRNTYRTKNNK.Y...PTWEYRG
  27 ...TVIQFVEEFLN.IRD.....TS.....RPLSDrd7ikKALRGVRIETNHQ.EdqiRRYKITG
  28 ...TVIQFVEEFLN.IRD.....TS.....RPLSDrd7ikKALRGVRIETNHQ.EdqiRRYKITG
  29 6skIKKNKNYKIYL.LPQ.....LV.....VPTYN.....AEQLESDVAKEIL.E...YTKLMPE
  30 6skIKKNKNYKIYL.LPQ.....LV.....VPTYN.....AEQLESDVAKEIL.E...YTKLMPE
  31 ...PVIDFVTQLLN.RDV.....SS.....RPLSDad9kaLRGVKVEVTHRGNmR...RKYRISG
  32 ...TVIQFVEEFLN.IRD.....TS.....RPLSDrd7ikKALRGVRIETNHQ.EdqiRRYKITG
  33 6skIKKNKNYKIYL.LPQ.....LV.....VPTYN.....AEQLESDVAKEIL.E...YTKLXPE
  34 ...LNIDMSSTAFI.EANpviqfVC.....DLLNRd18kaLRGVKVEVTHRGNmR...RKYRISG
  35 ...PVIDFVSQLLN.RDV.....WS.....RALSDad9kaLRGVKVEVTHRGNmR...RKYRIIG
  36 ...ICLTVDSSIVY.SGD.....LE.....QFYENhp8avKLLVGLKVKDRET.N...GTAKIIR
  37 ...ICLTLESSIVY.SGD.....LE.....QFYENhp8aaKLLVGLKVKTIET.N...GTAKIIR
  38 ...LNIDMSSTAFI.EANpviqfVC.....DLLNRd18kaLRGVKVEVTHRGNmR...RKYRISG
  39 ...TVIQFVEEFLN.IRD.....TS.....RPLSDrd7ikKALRGVRIETNHQ.EdqiRRYKITG
  40 ...IGFFLNHEFEY.QKT.....LD.....EEIKCg....NIQKGDKVKDFYN.N...ITYEFLE
  41 ...PVIEFVAKLLN.REV.....SP.....RPLADad9kaLRGIKVEVTHRGNmR...RRYRISG
  42 ...-----------.PVT.....VI.....QFVEEf20ikKALRGVRIETNHQ.EdqiRRYKITG
  43 ...LHLDLKFRIQP.FET.....LQ.....TLLERnd...FNPKRIRVKPIGI.D...FVGRVQD
  44 ...LHLDLKFRIQP.FET.....LQ.....TLLERnd...FNPKRIRVKPIGI.D...FVGRVQD
  45 ...ILLDCAFKILR.YRT.....VF.....EELKYnm9hdFDLQGQIVMTIYN.K...KFYQILS
  46 ...ITLTLKSRFLY.RGT.....LA.....EFYANhp8pkELLVGLKVRDRET.N...SSATIVE
  47 ...LEVDEHYKLFS.AWT.....LT.....QWLEWy....PDFSAKILRNTYD.G...RTWKLQK
  48 ...VGFDVRHRLLP.RPH.....LTld9rpEWMEG.....IRRVRHRYVSNGQ.Y...GTAELIG
  49 ...INVDVAHKGFPkNQP.....MI.....DAFTRd37gtGPSSGQLREHICN.G...VVDPPSR
  50 ...FGFDLTHQFEY.REN.....LL.....QQIKRdpksvSAGMRVIDSTHPK.S...YEYEFVE
  51 ...LILNFRHTASI.TKH.....LW.....DFVNRdkallEEYVGKKIIFKPN.P...KVRYTIS
  52 ...-----------.---.....--.....-----.....-------------.-...-------
  53 ...-LIEFRHSSGA.MPT.....LP.....KQMVKs....IKVKTKHLGHRKP.L...KAIGTTS
  54 ...-----------.---.....--.....-----.....-------------.-...-------
  55 ...-----------.---.....--.....-----.....-------------.-...-------
  56 ...-----------.---.....--.....-----.....-------------.-...-------
  57 ...-----------.---.....--.....-----.....-------------.-...-------
  58 ...-----------.---.....--.....-----.....-------------.-...-------
  59 ...-----------.---.....--.....-----.....-------------.-...-------
  60 ...-----------.---.....--.....-----.....-------------.-...-------
  61 ...LF---------.---.....--.....-----.....-------------.-...-------
  62 ...-----------.---.....--.....-----.....-------------.-...-------
  63 ...-----------.---.....--.....-----.....-------------.-...-------
  64 ...-----------.---.....--.....-----.....-------------.-...-------
  65 ...-----------.---.....--.....-----.....-------YRTYLN.R...KTTKPIL
  66 ...-----------.---.....--.....-----.....-------------.-...-------
  67 ...-----------.---.....--.....-----.....-------------.-...-------
  68 ...-----------.---.....--.....-----.....-------------.-...-------
  69 ...-----------.---.....--.....-----.....-------------.-...-------
  70 ...ICVDVKHRYVS.KNP.....IE.....ANIKRe24kl-------------.-...-----QD


       210            220       230                 240                
        |              |         |                   |                
   1 LGEEDPKELPLP.....GGLSLLDYHASKGRL.....QGREG.....GRVA.....WVAD.....
   2 IDDKMSPRSTFEkt7etVQISFIDYYKKNYGI.....EIMDW.....DQPL.....LISR.....
   3 IDDKMSPRSTFEkt7etIQISFIDYYKKNYGI.....EIMDW.....DQPL.....LISR.....
   4 VDFAQSPKSTFSckg..KDVSFIEYYLTKYNI.....RIRDH.....NQPL.....LISK.....
   5 LGEEDPKELPLP.....GGLSLLDYHASKGRL.....QGREG.....GRVA.....WVAD.....
   6 LGEEDPKELPLP.....GGLSLLDYHAFKGRL.....QGREG.....GRVA.....WVAD.....
   7 VDFGQTPKSTFSckg..KDISFVEYYLTKYNI.....RIRDH.....NQPL.....LISK.....
   8 VDFGQTPKSTFSckg..RDISFVEYYLTKYNI.....RIRDH.....NQPL.....LVSK.....
   9 VCFDTNPLSTFRyge..RDISYVEYYKEQYGL.....EIKDH.....QQPL.....LLNR.....
  10 IDWDKNPMLKFErkd..EEISLFDYYKHHYNI.....TIQDL.....KQPL.....LVHR.....
  11 ICFDQNPTCQFEikt..GCTSYVEYYKQYHNI.....NIKDV.....NQPL.....IYSI.....
  12 FTQERPQDILLDc....LGMSLAEYHLNKGAT.....EEEVQ.....QSYV.....VYVK.....
  13 FTQERPQDILLDc....LGMSLAEYHLNKGAT.....EEEVQ.....QSYV.....VYVK.....
  14 INREMNPKSEFEnqng.SKMSYMQYYSEKYKI.....NIKDT.....TQPL.....IEVL.....
  15 VSREMNPKSEFEnlkg.EKMSYMQYYQDKYKI.....AIKDV.....TQPL.....IEVL.....
  16 ISSLPIRELRFTledk.SEKTVVQYFAEKYNY.....RVKYQ.....ALPA.....IQTG.....
  17 ISSLPIRELRFTledk.SEKTVVQYFAEKYNY.....RVKYQ.....ALPA.....IQTG.....
  18 FADKSPNEIQIEa....LGISLAEYHRQEGAT.....QQEID.....ESRV.....VIVKki...
  19 ITPIPMSQLIFPvddngTRKTVVQYFWDRYNY.....RLKYA.....SWPC.....LQSG.....
  20 ISREMNPKSEFEnlkg.EKMSYMQYYQDKYKI.....AIKDV.....TQPL.....IEVL.....
  21 VDYTKSPSSTFKlrdg.TDISYATYYQQKYQV.....RIRDP.....KQPL.....LVSR.....
  22 VSSQPTNQLMFTlddeaTRVSVVQYFRQKYNI.....VLKYP.....SWPS.....LQAG.....
  23 ILSNQSPREIRLpe...QNISLAEYHLQKYNA.....LVEEV.....ES-S.....WVVE.....
  24 INWEDNPRTKFKksgg.AEITFVDYYRERGRIyd7lyVGEER.....HFIV.....QELQ.....
  25 ITPIPMSQLIFPvddngTRKTVVQYFWDRYNY.....RLKYA.....SWPC.....LQSG.....
  26 IISNQSPREVWLae...LNTSLADYHVQKYGA.....TPEEV.....DGSL.....VVQVvs6rn
  27 ITPIPMSQLIFPvddngTRKTVVQYFWDRYNY.....RLKYA.....SWPC.....LQSG.....
  28 ITPIPMSQLIFPvddngTRKTVVQYFWDRYNY.....RLKYA.....SWPC.....LQSG.....
  29 ERKELLENILAE.....VDSDIIDKSLSEIEV.....EKIAQ.....ELEN.....KIRV.....
  30 ERKELLENILAE.....VDSDIIDKSLSEIEV.....EKIAQ.....ELEN.....KIRV.....
  31 LTSQATRELTFPvddrgTMKSVVEYFYETYGF.....VIQHS.....QWPC.....LQVG.....
  32 ITPIPMSQLIFPvddngTRKTVVQYFWDRYNY.....RLKYA.....SWPC.....LQSG.....
  33 ERKELLENILAE.....VDSDIIDKSLSEIEV.....EKIAQ.....ELEN.....KIRV.....
  34 LTAVATRELTFPvdernTQKSVVEYFHETYGF.....RIQHT.....QLPC.....LQVG.....
  35 LTSQATRELTFPveeggCVKSVVEYFRETYGF.....SIQYA.....QLPS.....LQVG.....
  36 IAGRIGERREDL.....--LTKATGSISRRKL.....EEAHL.....GQPV.....VAVQ.....
  37 IAGTIGERREEL.....--LTKATGSISRRKL.....EEAHL.....GQPV.....VAVQ.....
  38 LTAVATRELTFPvdernTQKSVVEYFHETYGF.....RIQHT.....QLPC.....LQVG.....
  39 ITPIPMSQLMYLs22ngTRKTVVQYFWDRYNY.....RLKYA.....SWPC.....LQSG.....
  40 MAPFSISQENKY.....MRSSIIEYYLNKGQS.....YIISGld...KNTK.....AVLV.....
  41 LTSQTTRELTFPvdesgTMKSVVEYFSETYGF.....VIQHT.....QWPC.....LQVG.....
  42 ITPIPMSQLMYLs22ngTRKTVVQYFWDRYNY.....RLKYA.....SWPC.....LQSG.....
  43 VFKAKEKGEEFF.....RLCMERSTHKSSKKA.....WEELL.....KNRE.....LREKaf...
  44 VFKAKEKGEEFF.....RLCXERSTHKSSKKA.....WEELL.....KNRE.....LREKaf...
  45 VEFDKRPSDSFKneke.TYMTYEQYYKEKYNV.....QI-PL.....DQPL.....LRAS.....
  46 IAAIDEDRRKEL.....--IEKATGAVSRQAL.....EEAPD.....DQPL.....VSVR.....
  47 ITNEDPNNIDSG.....TGQTLATYHKNHQKPatdq.EINSS.....KVIY.....VKPY.....
  48 IATGRTALSTFPtpk..GEVSLLGYHESKGNL.....PEGER.....EAVAas6vqVRYG.....
  49 QTFTLENDKGPP.....VRMTVYEYFMKEKKY.....RIKYP.....DLNC.....LWVG.....
  50 VAPYRANEVSPI.....MRCSIIDYFAKKDPK.....RVIEP.....DA-L.....VVHV.....
  51 LVDAPNPQKIEE.....IMSHIIKYYKWSEDM.....VKSTF.....GEID.....YNQP.....
  52 ------------.....---------------.....-----.....----.....----.....
  53 ARNTYFDCEQFG.....GKISVEQYFLKAYNR.....KLRYP.....VELP.....VVDI.....
  54 ------------.....---------------.....-----.....----.....----.....
  55 ------------.....---------------.....-----.....----.....----.....
  56 ------------.....---------------.....-----.....----.....----.....
  57 ------------.....---------------.....-----.....----.....----.....
  58 ------------.....---------------.....-----.....----.....----.....
  59 ------------.....---------------.....-----.....----.....----.....
  60 ------------.....RYITVSQYFQQAHLL.....YLAYGitldsSFPV.....INVG.....
  61 ------------.....-SITPTVYFISNGQI.....KKEIK.....QQYS.....HEYL.....
  62 ------------.....---------------.....-----.....----.....----.....
  63 ------------.....---------------.....-----.....----.....----.....
  64 ------------.....---------------.....-----.....----.....----.....
  65 GFDYSNNSETLKfk6ndKLVNVKQYFQERWNI.....RLKHP.....TLPL.....IKIG.....
  66 ------------.....---------------.....-----.....----.....----.....
  67 ------------.....---------------.....-----.....----.....----.....
  68 ------------.....---------------.....-----.....----.....----.....
  69 ------------.....---------------.....-----.....----.....----.....
  70 HTGLSVSEQMISngta.KPIS-----------.....-----.....---L.....YQFI.....


           250                     260       270            280       2
            |                       |         |              |        
   1 PK..D..P....R.....KPIP...H..LTGLLVPVLTLEDLHEE.....EGSLALSLPWEERRR
   2 DT..K..RmpgsD.....TPTD...F..MICLIPELCQLTGLTDDqr9mkDVATYTRITPNQRHA
   3 DT..K..RmpgsD.....TPTD...F..MICLIPELCQLTGLTDDqr9mkDVATYTRITPNQRHA
   4 NK..D..K....A.....QKIN...AseVVVLIPELCRVTGLTESmr9mrAISDYTRMNPDRRID
   5 PK..D..P....R.....KPIP...H..LTGLLVPVLTLEDLHEE.....EGSLALSLPWEERRR
   6 PK..D..P....R.....KPIP...H..LTGLLVPVLTLEDLHEE.....EGSLALSLPWEERRR
   7 SR..D..K....A.....QKAN...AseVVVLIPELCRVTGLTDSmr9mrAMSEHTRMNPDRRID
   8 NK..D..K....A.....LKTN...AseLVVLIPELCRVTGLNDDmr9mrAMSSYTRMNPKQRID
   9 SE..R..RvvgkT.....EPEE...M..IVCLVPEICFLTGLTDEmr9mrDIATYTRITPNQRLV
  10 SK..E..K....Ktt9ylQTVE...K..VSLLIPELCFLAGITDSir9tkDLSQVTKVSPEQRRQ
  11 KK..S..R....G.....IPAErenL..QFCLIPELCYLTGLRDEvr9mrEIATFTRVSPNQRQM
  12 PI..SwrK....G.....KLTA...H..LSRRLSPSLTMEMLAKVa15irAVFKSIKQSINQRLQ
  13 PI..SwrK....G.....KLTA...H..LSRRLSPSLTMEMLAKVa15irAVFKSIKQSINQRLQ
  14 EK..S..R....K.....KQEE...K..IIYLIPELCVLTGLSNEmr9mkQLSTVTKPRGVDRVK
  15 EK..S..R....K.....KQEE...K..IIYLIPELCVMTGLSNEmr9mkQLSTVTKPRGVDRVR
  16 SD..T..R....P.....VYLP...M..ELCQIDEGQRYTKRLNE.....KQVTALLKATCQRPP
  17 SD..T..R....P.....VYLP...M..ELCQIDEGQRYTKRLNE.....KQVTALLKATCQRPP
  18 SD..Y..K....A.....KPVY...H..LSQRLSPILTMETLAQIa11iqGVFDYIRKNIGTRLQ
  19 SD..S..R....P.....VYLP...M..EVCKIVEGQRYSKKLND.....KQVTNILRATCQRPQ
  20 EK..S..R....K.....KQEE...K..IIYLIPELCVMTGLSNEmr9mkQLSTVTKPRGVDRVR
  21 SKarD..R....R.....AGND...E..LVYLIPELCRSTGLTDEmr9mrALAEHTRIAPEARMR
  22 SD..S..K....P.....IYLP...M..EVCKIVEGQRYTRKLND.....RQVTALLRATCQRPS
  23 VA..S..K....E.....RRYP...H..LSRRLSPALTLEMLASLe12saAVIECIRKSLKERFE
  24 PR..D..R....S.....FWID...V..LANAFSCRKSFDDAGGMf....GIAVVLQLQGVTRLQ
  25 SD..S..R....P.....VYLP...M..EVCKIVEGQRYSKKLND.....KQVTNILRATCQRPQ
  26 FR..Q..K....A.....EPIL...H..LSRRLSPVLTLEMLASIe12ssLVSEHIRKSLEERLK
  27 SD..S..R....P.....VYLP...M..EVCKIVEGQRYSKKLND.....KQVTNILRATCQRPQ
  28 SD..S..R....P.....VYLP...M..EVCKIVEGQRYSKKLND.....KQVTNILRATCQRPQ
  29 RD..D..K....G.....NSVP...I..SQLNVQKSQLLLWTNYSr....KYPVILPYEVPEKFR
  30 RD..D..K....G.....NSVP...I..SQLNVQKSQLLLWTNYSr....KYPVILPYEVPEKFR
  31 NQ..Q..R....P.....NYLP...M..EVCKIVEGQRYSKRLNE.....RQITALLKVTCQRPQ
  32 SD..S..R....P.....VYLP...M..EVCKIVEGQRYSKKLNN.....KQVTNILRATCQRPQ
  33 RD..D..K....G.....NSVP...I..SQLNVQKSQLLLWTNYSr....KYPVILPYEVPEKFR
  34 NS..N..R....P.....NYLP...M..EVCKIVEGQRYSKRLNE.....RQITALLKVTCQRPI
  35 NP..Q..R....P.....NYLP...M..EVCKISEGQRYTKRLNE.....NQITALLKVTCQRPM
  36 FG..K..N....P.....QEYI...Y..PLAALKPWVTDEDESLFqvnygNLLKATKIFYAERQE
  37 FG..K..N....S.....QEYI...Y..PLAALKPCMTDKDESLFqvnygELLKETKIFYAERQE
  38 NS..N..R....P.....NYLP...M..EVCKIVEGQRYSKRLNE.....RQITALLKVTCQRPI
  39 SD..S..R....P.....VYLP...M..EVCKIVEGQRYSKKLNN.....KQVTNILRATCQRPQ
  40 KN..K..E....G.....SIFP...Y..IPNRLKKICVFENLGNRrii..EGNKYIKMNPSQNMS
  41 NP..Q..R....P.....NYLP...M..EVCKIVEGQRYSRRLNE.....RQITALLKVTCQRPP
  42 SD..S..R....P.....VYLP...M..EVCKIVEGQRYSKKLNN.....KQVTNILRATCQRPQ
  43 LV..V..L....E.....KGYT...Y..PATILKPVLTYENLEDEern..EVADIVRMEPGKRLN
  44 LV..V..L....E.....KGYT...Y..PATILKPVLTYENLEDEern..EVADIVRXEPGKRLN
  45 MR..N..N....L.....GKNN...K..EIYLIPSLCQLTGLTDQir9mkNIATVTKPSGEQRIA
  46 FG..K..N....Q.....KLFD...Y..PMEALCPSITKETASKFdvnygDLIKQTKPPYQERQN
  47 NS..K..K....E.....ESYP...H..LSSRVKPCLFLDTLSELas9vkEVFNLIKPSIEDRFS
  48 RD..T..R....A.....KPME...H..LAALLQPMFGFDTLSQIds6leRIARSLKWPVGERLK
  49 PK..D..K....N.....IYLP...M..ELVEVAYGQARNKQLNDrqls.TMVREAATPPDVRKR
  50 KD..R..N....N.....QILI...Y..LPEQLKQSCSFETIPARhlg..AVSRIIKLSPDARMS
  51 IM..Y..C....E.....EILE...P..FAPQFCNLVFYMDELDS.....YILKELQSYWRLSNE
  52 --..-..-....-.....----...-..-------GLTEAGPLQV.....PLGDKIRVGVVGDAR
  53 GG..N..K....K.....VWVP...A..EMCDIEPGNAYRGKLNEk....ETAQMIRYACNPPRV
  54 --..-..-....-.....----...-..--CDPRQGLREHGPLQP.....RSGDVIRVGVIGTDD
  55 --..-..-....-.....----...-..-------GLFEAGPLQT.....PLGDVINIAVVGSAK
  56 --..-..-....-.....----...-..-----REGLRRLGPLQL.....HAGEVVTVGVIGSSE
  57 --..-..-....-.....----...-..-------GLLQAGPLQT.....NLGDTIKVGVVGSAL
  58 --..-..-....-.....----...-..----LRFGSTADNDVDV.....HPLRGLLRYGPYSRN
  59 --..-..-....-.....----...-..-----RQGIALFGPLDSie...GQPRRIRLGVVGTQQ
  60 NR..D..K....P.....TYMP...V..DICEVYPGQVAREKLTP.....AQMEEMVEFAAQRPW
  61 DK..M..R....N.....QQYE...K..KLQEWCNIMFNGKRLCF.....EIPVNSRSGFIFKIS
  62 --..-..-....-.....----...-..-----------------.....---------------
  63 --..-..-....-.....----...-..-----------------.....---------------
  64 --..-..-....-.....----...-..-----------------.....---------------
  65 P-..-..-....E.....AFLP...M..KLGIIAPHQQYKGDFADpa...KIIKITATRPNQKAE
  66 --..-..-....-.....----...-..-----------------.....---------------
  67 --..-..-....-.....----...-..-----------------.....---------------
  68 --..-..-....-.....----...-..-----------------.....---------------
  69 --..-..-....-.....----...-..-----------------.....---------------
  70 MN..N..A....P.....KPLP...R..EVIDMPPDSPAVKYMTSr24vkPTHRGTILLPNVRRQ


      90            300             310       320            330       
      |              |               |         |              |       
   1 RTREIASW.....IGRRLGLGTP...E...AVRAQAYRLSIPKLMGR.....RAVSKPADALRVG
   2 AFKKYIESv10srLAGWGLSIAP...E...TVNLTARTLPPETLYFGdn9kpNAEWNSEVTKHSV
   3 AFKKYIESv10srLAGWGLSIAP...E...TVNLTARTLPPETLYFGdn9kpNAEWNSEVTKHSV
   4 RLRRFNNRl10kvLNDWNMKLDE...N...LINVQGRIIAPQKIVFNq10saDWTRCFRDQRLLT
   5 RTREIASW.....IGRRLGLGTP...E...AVRAQAYRLSIPKLMGR.....RAVSKPADALRVG
   6 RTREIASW.....IGRRLGLGTP...E...AVRAQAYRLSIPKLMGR.....RAVSKPADALRVG
   7 RLRRFNHRl10kvLKDWNMDLDQ...N...LIEVQGRIISPQKIVFSd10tgDWTRYFRDQRMLT
   8 RLRTFNHRl10kvLRDWNMDLDK...N...VTEVQGRIIGQQNIVFHh10naDWQRHFRDQRMLT
   9 AMRQFCENv10klLASWGLELMI...T...PKVMMGRQLPPENITSGgg9gpNVDYTRQVTNNPM
  10 VIRKFIQQv10klLADWGLEIDN...D...TLDLTGRVLDPEELVFGnd8spNADWGKVATNSKV
  11 ALNKFYENv10eiLNSWGLSLTN...N...SNKISGRQMDIEQIYFSki8grSAEFSKHAVTNEM
  12 EAQKTASW.....ILTKTYGISS...Pai.ALSCDGYLLPAAKLLAAnk...QPVSKTADIRNKG
  13 EAQKTASW.....ILTKTYGISS...Pai.ALSCDGYLLPAAKLLAAnk...QPVSKTADIRNKG
  14 QADQFIQCfh9elIKKWNIQLES...K...CLQIQSSKVKPGNIIMGnn7niETGNLDRDTQTAM
  15 QADQFIQCfh9elIKKWNIQLEP...K...CLQIQSSKIKPGNIMMGnn7niETGNLDRDTQTAM
  16 DRENSIKNl11dlSKEFGMSVTT...Q...LASIEARVLPPPMLKYHds9vnPRLGQWNMIDKKM
  17 DRENSIKNl11dlSKEFGMSVTT...Q...LASIEARVLPPPMLKYHds9vnPRLGQWNMIDKKM
  18 ESQKIAQV.....IFKNVYNLSS...Qpe.IMKVNGFVMPRAKLLARnn...KEVNQTARIKSFG
  19 QREQSIHEm12rfAQEFGIKVCN...D...LVSVPARVLPPPMLKYHds9caPSVGQWNMINKKM
  20 QADQFIQCfh9elIKKWNIQLEP...K...CLQIQSSKIKPGNIMMGnn7niETGNLDRDTQTAM
  21 RLLAFNNRl10qdFKEWNFDLES...N...LVELPGRVLPMETIYFGsk7lkQADWTVDVQDAVP
  22 EREGNIQEm13vvRDEFGIRINE...E...LTLVDARVLPPPMLKYHds9vdPRVGQWNMIDKKM
  23 ESEETART.....IIKEVYKLSP...EeikPLKTQGYILPKPKLLGSgr...RPVENPARVRYRG
  24 GDERLGSS.....YEVGSRKKAA...R...ITETDEYYTNFDSHPQF.....-ADWSRETRSGPL
  25 QREQSIHE.....MVLHNKYTED...R...FAQEFGIKLKYHDSGREktca.PSVGQWNMINKKM
  26 ESKETAKT.....IIENVYNISDfqaD...PLKAEGYIMPSPRLLGFgh...RQVQNPARVRYQG
  27 QREQSIHE.....MVLHNKYTED...R...FAQEFGIKLKYHDSGREktca.PSVGQWNMINKKM
  28 QREQSIHE.....MVLHNKYTED...R...FAQEFGIKLKYHDSGREktca.PSVGQWNMINKKM
  29 KIREIPMF.....IILDSGLL--...-...-ADIQNFATNEFRELVK.....SMYYSLAKKYNSL
  30 KIREIPMF.....IILDSGLL--...-...-ADIQNFATNEFRELVK.....SMYYSLAKKYNSL
  31 EREHDIMQt12pyAKEFGIKISE...K...LASVEARILPAPWLKYHdt9clPQVGQWNMMNKKM
  32 QREQRIHEm12rfAQEFGIKVCN...D...LVSVPARVLPPPMLKYHds9caPSVGQWNMINKKM
  33 KIREIPXF.....IILDSGLL--...-...-ADIQNFATNEFRELVK.....SXYYSLAKKYNSL
  34 DREKDILQt12nyAQEFGIKIST...S...LASVEARILPPPWLKYHes9clPQVGQWNMMNKKM
  35 DREKDILKt12pyAKEFGIKISD...R...LASVEARILPPPRLKYHet9clPQVGQWNMMNKKM
  36 LLKLYKQE.....AQKALNNFGF...Q...LREKSINSQEYPELFWTp24iiKGLSKGGVYKRHR
  37 RLKLYKQE.....AQNTLNNFGF...R...LGEKSINSREYPELFWNp24tlKGLSKGGVYKRHR
  38 DREKDILQt12nyAQEFGIKIST...S...LASVEARILPPPWLKYHes9clPQVGQWNMMNKKM
  39 QREQRIHE.....MVLHNKYTDD...R...FAQEFGIKLKYHDSGREktca.PSVGQWNMINKKM
  40 ESIKLAED.....ILKNSKYVKF...N...KANMIVEKIGYKKDIVKr16amYGLNKSGSYEQKN
  41 DRENDITQ.....TVRHNAYHED...P...YAKEFGIKIS-------.....DKLAQVGQWNKKM
  42 QREQRIHE.....MVLHNKYTDD...R...FAQEFGIKLKYHDSGREktca.PSVGQWNMINKKM
  43 LIRYILRR.....YVKALRDYGW...Y...ISPEEERAKGKLNFKDTv14tnLRKFLELCRPFVK
  44 LIRYILRR.....YVKALRDYGW...Y...ISPEEERAKGKLNFKDTv14tnLRKFLELCRPFVK
  45 MAQTFIDQm17kiLSEWGLNINR...N...CLEMPAQTINPGNMLMGn11mnTNLDRQTQTQMYS
  46 HLTQSKQKa13idKSINNLDYPS...L...FQTLQFNLEDTELLFGK.....DSSGKHFVSKRGS
  47 RATEIAKQ.....LAVEIYNIDE...E...ISDDIKVVQVQAQQSSQd10ssKRIDKVFKSLDQG
  48 AAIRLVKG.....LKVSELDACL...Q...AVEDTQRFARDLKPEFRll6gaAVADSERAVLRHG
  49 KIEEVIQKmn8qfFKTYGLEIAN...E...FYQVEAKILEAPTLEVGpr6tvPKKGVWQANCLLK
  50 KLMPEALA.....LIGRLPMLQF...E...RQDVRAARLGYSIQTLPs14syAKTGLKQGGVYET
  51 NKGKIINE.....IAKKLRFIDN...T...PKELEFMKFNNTPLLVK.....DVNKNPTKIYSTN
  52 TVGSAKQF.....LAKAADGIES...T...ADSHPNMNPHFPGLQNN.....NPFRCQFVIEDEA
  53 NAEAIVGKg13gpLAGFDVSIDP...T...MAVVPGRELYPPKLTYKvgra.DVKNGSWNILDVK
  54 TVAGFTEF.....LAETGRGIES...G...NKQLINLNPDFPGLGNQ.....NPFRCKFEVPDGA
  55 TVKDSRDF.....LQAAAVGFAG...K...SEKHPNLHPPFPGLGNQ.....NPFRCRFEIPDGA
  56 TAEGFTQF.....LTESQQGVEA...A...SNTLPNLNPDFPGLGNA.....NPFGCRFVVPNTG
  57 TVEKSGEF.....LNAIEDGFEG...K...TEKHPNLHPDFPGLRNQ.....NPYRCRFEMVAAE
  58 WIAGVPDQ.....IRIAMIGQQG...M...IGKMRGLVSELEATLRP.....RDAAAYRPDYQGM
  59 TVDGILQW.....LERSKAGIKA...K...ASRQPHLFPDFPGFGAD.....SPFRADFNIDASS
  60 FNAEQITRs15ncLTENNITVGK...E...LITVPGRVLPQPKPQYRfg9gaGGWNMRNCKFNEV
  61 NNRGYAEIh17yn-------INQ...T...LYHGIHINEPKLEFINPy54rlNSTVSADKLSDYV
  62 --------.....----------...-...---CPNAHTNSLKSFLQrl...NTTIQANDNSDYI
  63 --------.....----------...-...-----------------.....-------------
  64 --------.....----------...-...-----------------.....-------------
  65 LISKTNRNlfq..KQVDFGTIES...Q...FTVVPARVLNAPTIEYAn23nw------NLERYQF
  66 --------.....----------...-...-----------------.....-------------
  67 --------.....----------...-...-----------------.....-------------
  68 --------.....----------...-...-----------------.....-------------
  69 --------.....----------...-...-----------------.....-------------
  70 YIHNF---v66alFNQKIGPYDS...R...PLDRQYMILPKSVWDSH.....GPVFLNDFKKIMN


      340       350              360       370            380          
       |         |                |         |              |          
   1 FYRAQETALALLRLDGA..Q.....GWPEFLRRALLRAFGASGAS.....LRLHTLHAH.....P
   2 MQAVDIMRWVLLFTQRD..K.....QVAMDFLSTLKRNCRPMGIM.....VSDAELVPL.....A
   3 MQAVDIMRWVLLFTQRD..K.....QVAMDFLSTLKRNCRPMGIM.....VSDAELVPL.....A
   4 TPSEGIDRWAVITPERN..S.....FDLKTVLDSLFRAASGMGLK.....IRSPHVIKI.....Q
   5 FYRAQETALALLRLDGA..Q.....GWPEFLRRALLRAFGASGAS.....LRLHTLHAH.....P
   6 FYRAQETALALLRLDGA..Q.....GWPEFLRRALLRAFGASGAS.....LRLHTLHAH.....P
   7 TPSDGIDRWAVIAPERN..S.....YDLKNLMENMFRAASGMGLR.....IKTPHELKI.....Y
   8 TPSDGLDRWAVIAPQRN..S.....SELRALLDCLYRASSGMGLR.....IRSPQEFII.....Y
   9 LEIVHIRQWMLLYTQRD..E.....QHASVFRDCVKRTCKLLGLE.....VAQPQVEVL.....P
  10 LRTPNMPDWAVLCTQKN..Q.....RNCNDFVETLKGVCQKVNIR.....IGDPRLIFL.....K
  11 LKVVHLSKWIIIHLRNY..R.....QAATSLLDNMKQACESLGMN.....ISNPTMISL.....D
  12 CAKIGETSFGYLNLYNN..Ql....QYPLEVHKCLLEIANKNNLQ.....LSLDQRRVL.....S
  13 CAKIGETSFGYLNLYNN..Ql....QYPLEVHKCLLEIANKNNLQ.....LSLDQRRVL.....S
  14 LRGVGLENWAILYGDRD..S.....RQAEDFMSCLRESIEYCKFQ.....CKAPRTFTI.....H
  15 LRGVGLENWGILYSDRD..G.....RQAEDFMSCLRESIEYCKFQ.....CKAPRTFVL.....H
  16 VNGAKVTSWTCVSFSTRidR.....GLPQEFCKQLIGMCVSKGME.....FKPQPAIPF.....I
  17 VNGAKVTSWTCVSFSTRidR.....GLPQEFCKQLIGMCVSKGME.....FKPQPAIPF.....I
  18 CAKIGETKFGCLNLFDN..Kp....EYPEEVHKCLLAIARSSGVQ.....IKIDSYFTG.....S
  19 INGGTVDNWTCLSFSRM..Rp....EEVQRFCGDLIQMCNATGMS.....FNPRPVVDV.....R
  20 LRGVGLENWGILYSDRD..S.....RQAEDFMSCLRESIEYCKFQ.....CKAPRTFVL.....H
  21 VSCRPLKDWVAIVPNKS..S.....ESAKAFIELIITVASKMKFA.....ISRPRLVMI.....D
  22 VNGGTVQFWTCLNFSFRvhQ.....DLPSGFCRELVNMCVSKGMV.....FNPNPLLPI.....Q
  23 CAKVGETKFACLNLYDD..Kr....EYPSEVLNCLLEVAQKSGAE.....IEVDFYATQ.....Q
  24 LNVKSLDHWLILYPTRN..Y.....GAASSLVQSLRKVTPTMGIA.....MREAKMLEV.....S
  25 INGGTVDNWTCLSFSRM..Rp....EEVQRFCGDLIQMCNATGMS.....FNPRPVVDV.....R
  26 CARVGETKFGLLNLDDN..Kr....EYPTEVRKCLLEVAKKSGAR.....VEIDFYATR.....Q
  27 INGGTVDNWTCLSFSRM..Rp....EEVQRFCGDLIQMCNATGMS.....FNPRPVVDV.....R
  28 INGGTVDNWTCLSFSRM..Rp....EEVQRFCGDLIQMCNATGMS.....FNPRPVVDV.....R
  29 AKKARSTNEIGLPFLDF..R.....GKEKVITEDLNSDKGIIEVV.....EQVSSFMKG.....K
  30 AKKARSTNEIGLPFLDF..R.....GKEKVITEDLNSDKGIIEVV.....EQVSSFMKG.....K
  31 VNGGTVNNWICINFSRGvqE.....SVARGFCQELAQMCYISGMA.....FNPEPVLPP.....I
  32 INGGTVDNWTCLSFSRM..Rp....EEVQRFCGDLIQMCNATGMS.....FNPRPVVDV.....R
  33 AKKARSTNEIGLPFLDF..R.....GKEKVITEDLNSDKGIIEVV.....EQVSSFXKG.....K
  34 INGGTVNNWICINFSRQvqD.....NLARTFCQELAQMCYVSGMA.....FNPEPVLPP.....V
  35 VGGAAVNYWICVNFARNvqE.....RAAGGFCYELANMCNVSGMQ.....FKPEPVLPA.....Y
  36 EYVDPARKIRLAILKPA..N.....LKVGDFREQLEKRLKLYKFEt10inFSVEGLGFE.....K
  37 EYLDPARKIRLAILKPA..N.....LKVGDFREQLEKRLELYKFEt10inFSVEGVGFE.....K
  38 INGGTVNNWICINFSRQvqD.....NLARTFCQELAQMCYVSGMA.....FNPEPVLPP.....V
  39 INGGTVDNWTCLSFSRM..Rp....EEVQRFCGDLIQMCNATGMS.....FNPRPVVDV.....R
  40 IEIDYFIDPKILNNKRD..Y.....QIVYSFLNDIISKSKDLGVE.....INTDKSYINltpinI
  41 VNGGTVNNWFCVNFSRSvpD.....KSAHAFCCELANMCHISGMA.....FNPEPVLPP.....L
  42 INGGTVDNWTCLSFSRM..Rp....EEVQRFCGDLIQMCNATGMS.....FNPRPVVDV.....R
  43 KDVLSVEIISVSVYKKL..E.....WRKEEFLKELINFLKNKGIK.....LKIKGKSLI.....L
  44 KDVLSVEIISVSVYKKL..E.....WRKEEFLKELINFLKNKGIK.....LKIKGKSLI.....L
  45 TPQQQLILGIIMNEKSG..S.....QVLDVFMENFLAACHEFKFF.....TFLPPKVLS.....I
  46 VLKGLSQGGVYRRHQDY..E.....NYSTPIRISLLNLCNSKVGK.....FVSQVEERL.....K
  47 CFRVGEIKFGCINLLDK..Nqd...GWSKFILQKLQKLATIHNIN.....IDANLVKAA.....V
  48 AYQGMTRKLVVPLVVGG..T.....ALEQAVAVRHFEAVERVCRQ.....WHSDLPSWK.....T
  49 PEALNSWGFIAIELDPR..G.....CNYEDIVSKLMNTGRQMGMN.....VTQPKMACF.....N
  50 GEATVSFFVDPKLRDHQ..K.....LQVLEFINKLKTTSERFGVT.....LNVSHKPKG.....L
  51 TLFTWIYNQNAKIYLPY..Dv14yiLIDEEIKDELKAIKDKVNKM.....FRNYNKIAN.....K
  52 TATLSKAQIDKIRKEPN..Ha....KAVEMAVDAVVDLLQVLDDS.....GDRPDVALV.....A
  53 FQQGATITSWWVMVVRD..G.....HNMLSGPKDPRLMGLVQGFA.....TKLKNSGVN.....I
  54 TVTISRRQVNDITGIGR..H.....DEAVRHAVELISSQLSALVE.....GSAKPDVIV.....L
  55 VTAIPQARIERIRKEPH..Hg....KAVEMAVDEIIEQLQTIDEG.....SSRPDVAII.....A
  56 QRALSKRQIKKIVQASS..T.....QEAINLLLDAVEAEARVLQE.....SSAKPDVVV.....F
  57 DGVLTKGQIEKIAKEPS..Da....RAVEIAVDAVMAQLEKLEAH.....HERPDVVMV.....S
  58 SKTFGVRPVGAGSASEI..I.....LPDTLTDDVRRARKPYVVLA.....EALQRAITQ.....L
  59 VRTLSSRELSRITAQSE..L.....MAVADGQSMLADEVQAISES.....GRPDVVIVG.....V
  60 VGGGTSRPWGCLTLDGR..Y.....PANSQHLVAQLEAFRLHLSK.....AGINLDQCK.....I
  61 HHYTGFSNIYNCRLDIP..E.....IHSEKWVSINDNPKSAINLA.....KTICTEGQK.....L
  62 QPYTGFHSIYKTLLEIP..D.....SDTDKWIKTEDTPRDTISLA.....QSICHKAGS.....L
  63 -----------------..-.....--------------------.....----RKIQA.....L
  64 -----------------..-.....--------------------.....----RAIQS.....L
  65 VDGAKLTKPMGKPFTFGv.-v12riGDLQRAVPTFLTELGRLGIKig9ysIDLNHASVQ.....S
  66 -----------------..-.....--------------------.....---------.....-
  67 -----------------..-.....--------------------.....---------.....-
  68 -----------------..-.....--------NLIKRKLKLIYE.....KETPPDIIL.....I
  69 -----------------..-.....--------------------.....---------.....-
  70 ELYLHELPYNPIVVTYN..D.....LSAKTYALQGRAILDAVDSE.....LREPGYGVV.....M


        390               400       410                 420        430 
         |                 |         |                   |          | 
   1 SQGLAFRE...ALRKAK.....EEGVQAVLVLTPPMAWE.....DR.....NRLKALL.LREGLP
   2 NDRTDTYV...LALKKCi....TSSVQLVVAICSTKRDD.....RYa....AIKKVCC.ADNPVP
   3 NDRTDTYV...LALKKCi....TSSVQLVVAICSTKRDD.....RYa....AIKKVCC.ADNPVP
   4 DDRTGSYV...RAMDSCa....DMDPKLILCLVPNNNVE.....RYs....SIKKRGC.VDRAVP
   5 SQGLAFRE...ALRKAK.....EEGVQAVLVLTPPMAWE.....DR.....NRLKALL.LREGLP
   6 SQGLAFRE...ALRKAK.....EEGVQAVLVLTPPMAWE.....DR.....NRLKALL.LREGLP
   7 DDRTATYI...RAMDDCa....RMDPKLILCLVPNNNAD.....RYs....AIKKRGY.VDRAVP
   8 DDRTATYV...RAMDDCa....RSDPKLILCLVPNDNVE.....RYs....SIKKRGY.VDRAVP
   9 QDATNLYV...QALRTRi....RPGTQIVVIICPTSRDD.....RYa....AIKRILC.TEVPIP
  10 DDSTETYVs..ELRKVV.....KNRLNMVVIIFPALRQD.....KYs....AVKKICC.VETPVP
  11 HDRIDAYI...QALRRNi....TMNTQMVVCICHNRRDD.....RYa....AIKKICC.SEIPIP
  12 DYPQDDLD...QQMFWQtws..SQGIKTVLVVMPWDSHH.....DK.....QKIRIQA.IQAGIA
  13 DYPQDDLD...QQMFWQtws..SQGIKTVLVVMPWDSHH.....DK.....QKIRIQA.IQAGIA
  14 SSRIEDWI...KQIDFIvq6qgPQKVTLLLLILNGPKKN.....APlyt..DLKRYLI.NDCPIA
  15 SNRIEDWI...KQIDQIvq6qgPQKVTLLLLILNGPKKN.....APlyt..DIKRYLI.NDCPIA
  16 SCPPEHIE...EALLDIhkr..APGLQLLIVILPDVTGS.....YG.....KIKRICE.TELGIV
  17 SCPPEHIE...EALLDIhkr..APGLQLLIVILPDVTGS.....YG.....KIKRICE.TELGIV
  18 DYPKDDLA...QQRFWQqwa..AQGIKTVLVVMPWSPHE.....EK.....TRLRIQA.LKAGIA
  19 STNPNNIE...NALRDVh12egKGGLQLLIVILPEVSGS.....YG.....KIKRVCE.TDLGIV
  20 SNRIEDWI...KQIDQIvq6qgPQKVTLLLLILNGPKKS.....APlyt..DIKRYLI.NDCPIA
  21 NDKSETVA...QTITAItd...KSVPQLIFCVVFNNNLL.....RYq....AIKKKLC.LDRPIP
  22 SAHPNQIE...KVLVDVh14qnGKQLQLLIIILPDVTGS.....YG.....KIKRICE.TELGIV
  23 DLPKGDLA...RKRFWQtwa..EQGIKTVLVVMPWSPNE.....RK.....QRIRMEA.LEAGIA
  24 DTVQSYTT...VLENHV.....SSKTQMVLCVLSSEKKD.....LYd....GIKQYLC.VNCPTP
  25 STNPNNIE...NALRDVh12egKGGLQLLIVILPEVSGS.....YG.....KIKRVCE.TDLGIV
  26 DLPEGDLA...QQRFWQswa..DKGIKTVLVVMPLSPNE.....HK.....QKIRLQA.LRAGIA
  27 STNPNNIE...NALRDVh12egKGGLQLLIVILPEVSGS.....YG.....KIKRVCE.TDLGIV
  28 STNPNNIE...NALRDVh12egKGGLQLLIVILPEVSGS.....YG.....KIKRVCE.TDLGIV
  29 ELGLAFIA...ARNKLS.....SEKFE------------.....--.....-EIKRRL.FNLNVI
  30 ELGLAFIA...ARNKLS.....SEKFE------------.....--.....-EIKRRL.FNLNVI
  31 TARPDQVE...RVLKARf11pqGKELDLLIVILPDNNGS.....LYg....DLKRICE.TDLGLV
  32 SSNPNNIE...NALRDVh12egKGGLQLLIVILLEVSGS.....YG.....KIKRVCE.NDLGIV
  33 ELGLAFIA...ARNKLS.....SEKFE------------.....--.....-EIKRRL.FNLNVI
  34 SARPEQVE...KVLKTRy10sqGKEIDLLIVILPDNNGS.....LYg....DLKRICE.TELGIV
  35 NARSDQVE...RMLKSRik8taKQGIDLLIAILPDNNGS.....LYg....DLKRICE.TDLGVI
  36 RARLEEAV...DRLIGV.....EIPVDIALVFLPQEDRNad8gsLY.....SWIKRKF.LGRGVI
  37 RARLEEAV...DQLIRG.....EIPVDIALVFLPQEDRNad8gsLY.....SWIKKKF.LERRVM
  38 SARPEQVE...KVLKTRy10sqGKEIDLLIVILPDNNGS.....LYg....DLKRICE.TELGIV
  39 SSNPNNIE...NALRDVh12egKGGLQLLIVILLEVSGS.....YG.....KIKRVCE.NDLGIV
  40 KNENVFEL...NIIQII.....ENYNNPVLVILEKENID.....KYye...TLKKIFG.GRNNIP
  41 SARPDQVE...KVLRRRyh9lqGKEPDLLIVILPDNNGS.....LYg....DLKRICE.TDLGVV
  42 SSNPNNIE...NALRDVh12egKGGLQLLIVILLEVSGS.....YGmy7wgKLKGYVR.MTLALY
  43 AQTREEAK...EKLIPVi10lvIVFLEEYPKVDPYKSFL.....LY.....DFVKREL.LKKMIP
  44 AQTREEAK...EKLIPVi10lvIVFLEEYPKVDPYKSFL.....LY.....DFVKREL.LKKXIP
  45 NSDTDDEL...ERVCDNlk8lnKVKVGFLIFLLPGQKKK.....AKlyk..TAKKISM.QSFGCP
  46 QYKFETIR...FEKDSLd36vlTFLPESDRHTDDTEDGS.....FY.....SFVSSRL.LRRGIS
  47 DIPEKDFEidqFWESWV.....EQDIKTILVISEWLDNK.....YK.....TKLTRDA.LEHGIT
  48 APPAGDAE...ALNQRLa....QRKPENALLLIGLGRGA.....DK.....RKIRNVA.YRYGLA
  49 IRINDLHK...SMLHAL.....EKQVNFLVVVVSGRGRD.....YYh....KLKQIAE.LKVGIL
  50 SQKLPSDL...LQTEDIl10qhFEGVVVVIAEEASLQHS.....YQ.....AIKRQFG.GKQDVV
  51 TELPKFNY...ANRWKYf19ndEICFALIIGKEKYKDND.....YY.....EILKKQL.FDLKII
  52 LPVALIER...VWNAKId....AEGTTEKDDSGGSDAPN.....FR.....GLLKAKA.MSLNFP
  53 PTGLPRLI...PPPTLPp25ktQKKPSFVLVLLENRDNY.....IYp....GIKRICD.VELGIH
  54 ALPIPLIE...KLVNAK.....SEGEDSDDDVDGGDMLN.....FR.....DLLKAKT.LHLPVP
  55 LPVELIER...VWNAKV.....DSDATLEEEDSSGSDAPn....FR.....GMLKAKA.MHFRFP
  56 SMPIDLIE...KVVMAR.....SENGEPDDDGGPDV-LN.....FR.....DMMKAKM.MELGVA
  57 LPVKLIER...VWRNERar6egIEGEAADAKAGRETSPN.....FR.....GLLKARA.MDLRFS
  58 KATRNDFD...VVFIGI.....DAAWEPAFVERDEEDFD.....LH.....DYLKAVG.ASMGVS
  59 PQELVALE...DNDANEat...AEFNPKQDALEYGSTFD.....LR.....NMLKAKV.MRMNQP
  60 RSCTVGRS...TTQDFSv18giRRPFDFVLIILPDKDVS.....RY.....NMIKYLGdVCYGVP
  61 SEQFPGIV...LLIFVP.....NSWSNYRQFNYHGETFD.....LH.....NYIKAFA.AQHRFT
  62 AEKYPGIV...VVIYIP.....TSWSLHKQFKHDGESFD.....LH.....NYIKAYA.AQHSFT
  63 EAHRDKFD...VLFIYI.....PQRWTPGYTGSHGEDFD.....LH.....DHLKAAT.AARRLP
  64 EARRDAFD...IVFIYI.....PLSWAAGFSGAEGDDFD.....LH.....DHLKAAT.AARRIP
  65 QTGLESNI...I-----si8ktEDQCNFLLFILPRQDTP.....LYs....AIKRACD.LKVGIL
  66 --------...------skaknKDKCDFLLVVLPSKDAR.....FYr....AVKRAGD.LKVGIN
  67 --------...------.....----EAWLPYTSGDGFD.....AH.....DVLKALG.AKHGIP
  68 SFPQEFYT...ICECSEtd6liKVGID-----------D.....FR.....NRIKLLA.MQQKIP
  69 --------...------ea8lsSGDIDLAIVITSEAQAHlt6ssPY.....LVAKSAF.MGQGVP
  70 IHETVDRR...NRQHDQla9el-----------------.....--.....-------.RNRRLY


             440             450        460                     470    
              |               |          |                       |    
   1 SQIL.NVPLREEE.R.....HRWENALLGLLAKA.GLQVVAL....SGA.....Y.....PAELA
   2 SQVI.NARTLMNT.Nkir..SITQKILLQLNCKL.GGTLWSI....SIP.....F.....KSAMI
   3 SQVI.NARTLMNT.Nkir..SITQKILLQLNCKL.GGTLWSI....SIP.....F.....KSAMI
   4 TQVV.TIKTSKNR.Gll...SIATKIAIQLNCKL.GYTPWMI....ELP.....L.....SGLMT
   5 SQIL.NVPLREEE.R.....HRWENALLGLLAKA.GLQVVAL....SGA.....Y.....PAELA
   6 SQIL.NVPLREEE.R.....HRWENALLGLLAKA.GLQVVAL....SGA.....Y.....PAELA
   7 TQVV.TIKTAKNR.Glm...SIATKIAIQINCKL.GYTPWMV....EVP.....L.....SGLMT
   8 TQVV.TIKTTKNR.Slm...SIATKIAIQLNCKL.GYTPWMI....ELP.....L.....SGLMT
   9 SQVI.NARTLANE.Krnr..SVVLKVLLQMNCKL.GGSLWGV....RVP.....I.....KRTMI
  10 SQVI.ISRTIAKP.Eklk..SVTEKIALQINCKL.GGALWAL....KNP.....F.....TNAMV
  11 SQVI.NAKTLQNDl-kir..SVVQKIVLQMNCKL.GGSLWTV....KIP.....F.....KNVMI
  12 TQFM.VP-LPKAD.K.....YKALNVTLGLLCKA.GWQPIQLesv.DHP.....E.....VADLI
  13 TQFM.VP-LPKAD.K.....YKALNVTLGLLCKA.GWQPIQLesv.DHP.....E.....VADLI
  14 SQVI.LSSTLNQP.Kgkvk.TICNKLLVQICAKV.GGTPWGIsdl.PFT.....D.....QPTMI
  15 SQVI.LSSTLNQP.Kgkvk.TICNKLLVQICAKV.GGTPWGVsel.PFT.....D.....QPTMI
  16 SQCC.QPRQVNKL.Nk....QYMENVALKINVKT.GGRNTVL....NDAir9itD.....RPTII
  17 SQCC.QPRQVNKL.Nk....QYMENVALKINVKT.GGRNTVL....NDAir9itD.....RPTII
  18 TQFM.IP-TPQDN.P.....YKALNVALGLLCKA.KWQPVYLkpl.DDP.....Q.....AADLI
  19 SQCC.LPRHASRP.Nk....QYLENVALKINVKV.GGRNTVL....ERA.....Fi10seVPTII
  20 SQVI.LSSTLNQP.Kgkvk.TICNKLLVQICAKV.GGTPWGVsel.PFT.....D.....QPTMI
  21 SQVV.MSRTLVQK.TpantrSVATKVAVQLNCKM.GGVPWTTdi..GQI.....L.....PGLMV
  22 SQCC.QPSQASKL.Nk....QYFENVALKINVKV.GGRNTVLf...-DAiq9vsD.....LPTII
  23 TQFM.IPG---AD.P.....YKALNVVLGLLCKA.AWQPVLLepl.DDP.....V.....GPELI
  24 SQCV.VARTLDKP.Qtlm..TIATKIAQQMNCKM.GGALWKV....ETG.....L.....QNAMF
  25 SQCC.LPRHASRP.Nk....QYLENVALKINVKV.GGRNTVL....ERA.....Fi10seVPTII
  26 TQFM.IPG---AD.P.....YKALNVVLGLLCKA.AWQPVLLepl.DHP.....E.....CSELT
  27 SQCC.LPRHASRP.Nk....QYLENVALKINVKV.GGRNTVL....ERA.....Fi10seVPTII
  28 SQCC.LPRHASRP.Nk....QYLENVALKINVKV.GGRNTVL....ERA.....Fi10seVPTII
  29 SQVV.NEDTLKNK.Rd10dlFVRHNLLFQVLSKL.GVKYYVL....DYR.....F.....NYDYI
  30 SQVV.NEDTLKNK.Rd10dlFVRHNLLFQVLSKL.GVKYYVL....DYR.....F.....NYDYI
  31 SQCC.LHKHVYRM.Sk....QYLANVALKINVKV.GGRNTVLv...-DAis9vsD.....RPTII
  32 SQCC.LPRHASRP.Nk....QYLENVALKINVKK.SQQSSLVl...---.....-.....-----
  33 SQVV.NEDTLKNK.Rd10dlFVRHNLLFQVLSKL.GVKYYVL....DYR.....F.....NYDYI
  34 SQCC.LTKHVFKM.Sk....QYMANVALKINVKV.GGRNTVL....VDA.....Lsr9sdRPTII
  35 SQCC.LAKHVFRM.Sk....QYLANVALKINVKV.GGRNTVL....VDA.....Lsw9sdRPTII
  36 TQMI.YEKTLNDK.Snyk..NILNQVVPGILAKL.GNLPYVLa...EPL.....E.....IADYF
  37 TQMI.YEKTLNDK.Snyk..NILNQVVPGILAKL.GNLPYVLa...ESL.....E.....IADYF
  38 SQCC.LTKHVFKM.Sk....QYMANVALKINVKV.GGRNTVL....VDA.....Lsr9sdRPTII
  39 SQCC.LPRHASRP.Nk....QYLENVALKINVKK.SQQSSLVl...---.....-.....-----
  40 TQFV.DLDTIKKC.Dp10keSIFLNILLGIYCKS.GIQPWVL....ANG.....L.....SADCY
  41 SQCC.LTKHVFKM.Nk....QYLANVSLKINVKV.GGRNTVL....VDA.....Lsr9sdRPTII
  42 LNVV.CQGMPAGR.Ts....NICENVALKINVKV.GGRNTVL....ERA.....Fi10seVPTII
  43 SQVI.LNRTLKNE.Nlk...FVLLNVAEQVLAKT.GNIPYKLk...EIE.....G.....KVDAF
  44 SQVI.LNRTLKNE.Nlk...FVLLNVAEQVLAKT.GNIPYKLk...EIE.....G.....KVDAF
  45 SQVI.IEKTLQKN.Tr....SIVNKILIQLNAKV.GGIPWAL....DGFpqqfqA.....KPTMI
  46 SQVI.YEDTLKNP.Nnys..YILNQVIPGILAKL.GNLPFILa...KPL.....E.....IADYF
  47 LQFM.LPLKENVR.Ri18dqYRANNILLGLLAKA.GWQAVGLpll.NNE.....Y.....AADLV
  48 TQFM.RLDHPPRT.Yqs...TYYNNLAAGVFSKG.GGVLCAId...DMP.....G.....ETDLF
  49 THVF.KEDTATRR.Mnp...QTARNILLKVNSKL.MGINQAL....ENRsi7lkG.....GAVMI
  50 TQCVeLHDRVLNS.E.....DTLYNILLGIYVKA.GLQPWIL....GEP.....L.....HSDCF
  51 SQNI.LWENWRKD.Dkg...YMTNNLLIQIMGKL.GIKYFIL....DSK.....T.....PYDYI
  52 IQIL.WEDVIDEK.Ak18eaGRSWNLLTTLYYKGsGRIPWRRlp..KEG.....E.....FRACY
  53 TVHM.QLGKALTD.Erkqd.QYFSNVALKVNTKL.GGMNHLL....EPN.....Amn6tkKKTMM
  54 TQIV.WPDTWDDA.Ak18kaTRAWNLLNALFYKA.GKVPWRLlp..DQA.....E.....YRTSF
  55 IQIV.WEDVLDER.Av18qaSRTWNLLTTLYYKG.SGRVPWRrap.QEG.....E.....FSACY
  56 TQIV.WPDVFDPD.Ak18paTRTWNLLNGLFYKA.GKVPWRLy...EPR.....D.....YTTNF
  57 IQIV.WEDVINPD.Ak18raDLAWNLMTTLYYKG.SGKVPWRrlp.EEG.....E.....FTACY
  58 VQLI.RSDKALDY.Hcra..SVMWRLSIALYTKA.GGVPWVL....EDI.....H.....PQTAF
  59 IQLV.LPQTYDET.Ak17eaTRAWNFHTALYYKA.NYRPWRIvr..DPS.....E.....FQACF
  60 TVCV.ASRTFFPA.Rgad..QMFGNLGLKINLKL.GGVNHKI....EDS.....Llg6aqGKTMI
  61 TQFI.EEKTLYNK.Mvc...KISWWLSLALFVKA.LRTPWTL....ADL.....D.....QNTAY
  62 TQII.EEKTLKDP.Mvc...EICWWLSLALFVKA.MRIPWAL....ASL.....D.....SDTAY
  63 VQFV.REDKALAY.Phra..SVMWRIGLALYAKA.GGVPWKL....AET.....D.....AETAY
  64 IQLV.REDRALAY.Pdra..SVMWRIGLAIYAKA.GGVPWKL....ADS.....D.....PEAAY
  65 NSCS.ILNTFTKK.Rrg8daMTYAQMAMKINIKL.GGSNHKLskkd---.....-sq9nnVPIFI
  66 NSCV.IVDTFTKR.Kfd6dmTLFAQVGMKVNLKL.GGSNHKL....SDAnskg.-lv6kkVPVFI
  67 TQVV.NDRTFSFS.Nka...QLAWRLSIALYVKA.GGIPWKL....APL.....Vgvp..ADTAY
  68 SQIV.RPETLLLD.GtqercIVAWNLVVGMLYKCqKGHPWKL....THL.....E.....ENTCY
  69 VQEV.RIETVRQS.Kla...YPLNSIALACYAKL.GGIPFVIaa..PRT.....L.....AHELV
  70 VSVI.HTTVTKDC.Yq24ngYLRNVAITKVLLTN.ERWPFVI....STP.....L.....HADFT


         480            490            500            510       520    
          |              |              |              |         |    
   1 VGFDAGG.....RESFRFGGAAC.....AVGGDGGHLLWTLPEA.....QAGERIPQEVVWDL..
   2 VGIDSYH.....DPSRRNRSVCS.....FVASYNQSMTLWYSKVif...QEKGQEIVDGLKCC..
   3 VGIDSYH.....DPSRRNRSVCS.....FVASYNQSMTLWYSKVif...QEKGQEIVDGLKCC..
   4 IGFDIAK.....SARDRRKAYGA.....LVASMDLQQNSTYFSTvse..CSAFDVLANNLWPM..
   5 VGFDAGG.....RESFRFGGAAC.....AVGGDGGHLLWTLPEA.....QAGERIPQEVVWDL..
   6 VGFDAGG.....RESFRFGGAAC.....AVGGDGGHLLWTLPEA.....QAGERIPQEVVWDL..
   7 IGFDIAK.....STRDRKKAYGA.....LVASMDLQQNSTYFSTvse..CSAFDSLSNNLWPM..
   8 IGFDIAK.....STRDRKRAYGA.....LIASMDLQQNSTYFSTvte..CSAFDVLANTLWPM..
   9 CGIDTYH.....EAKQRSNSVAA.....FVGSLDAAFTHWYSRAtv...QERKEEILNGLCVS..
  10 CGIDVFHag...VGQGSKGSVAA.....FIASLDKMLTSWHSRVcl...QAPHQELVDLLSQC..
  11 CGIDSYH.....DPSNRGNSVAA.....FVASINSSYSQWYSKAvv...QTKREEIVNGLSAS..
  12 IGFDTGT.....NRELYYGTSAF.....AVLADGQSLGWELPAV.....QRGETFSGQAIWQT..
  13 IGFDTGT.....NRELYYGTSAF.....AVLADGQSLGWELPAV.....QGGETFSGQAIWQT..
  14 CGMDVYH.....STAKGRKSMLS.....FVSTEDEFFSKYMTQSiem..DSGVEFSFSLCPIL..
  15 CGMDVYH.....STGKAKKSMLS.....FVSTEDEFFSKYMTQSiem..ETGVEFSFSLCPVL..
  16 MGADVTHpq...PGEDSSPSIAA.....VVASMDWPEINKYRGLvsa..QAHREEIIQDLYKLv1
  17 MGADVTHpq...PGEDSSPSIAA.....VVASMDWPEINKYRGLvsa..QAHREEIIQDLYKLv1
  18 IGFDTST.....NRRLYYGTSAF.....AILANGQSLGWELPDI.....QRGETFSGQSIWQV..
  19 FGADVTHpp...PGEDSASSIAA.....VVASMDWPEITKYRGLvsa..QPHRQEIIEDLFSVg1
  20 CGMDVYH.....STGKAKKSMLS.....FVSTEDEFFSKYMTQSvem..ETGVEFSFSLCPVL..
  21 VGFDVCH.....DKNGDFG---A.....LVASLDQNFARYYSAVsv...HAAGEELSNHFAQL..
  22 FGADVTHpq...PGEDSSPSIAA.....VVASMDWPEVTKYRGLvsa..QHHREEIIQDLYKTt1
  23 IGFDVGT.....NRRLYYGASAF.....AVLADGQSLGWELPAV.....QRGETFSGDAIYQT..
  24 IGIDCFH.....DIVNRRKSIAG.....FVSSINQELTQWFSQCif...QESGQELVNGLKTC..
  25 FGADVTHpp...PGEDSASSIAAv14ylVVASMDWPEITKYRGLvsa..QPHRQEIIEDLFSVg1
  26 IGFDVGT.....NRELYYGTSAF.....AVLANGQSLGWELPDI.....QRGETFSGEAIYQT..
  27 FGADVTHpp...PGEDSASSIAA.....VVASMDWPEITKYRGLvsa..QPHRQEIIEDLFSVg1
  28 FGADVTHpp...PGEDSASSIAA.....VVASMDWPEITKYRGLvsa..QPHRQEIIEDLFSVg1
  29 IGIDVAPmk...RSEGYIGGSAV.....MFDSQGYIRKIVPIKIge...QRGESVDMNEFFKE..
  30 IGIDVAPmk...RSEGYIGGSAV.....MFDSQGYIRKIVPIKIge...QRGESVDMNEFFKE..
  31 FGADVTHph...PGEDSSPSIAA.....VVASQDWPEITKYAGLvca..QAHRQELIQDLYKTw1
  32 --MSHTP.....PGEDSASSIAA.....VVASMDWPEITKYRGLvsa..QSHRQEIIEDLFSVg1
  33 IGIDVAPxk...RSEGYIGGSAV.....XFDSQGYIRKIVPIKIge...QRGESVDXNEFFKE..
  34 FGADVTHph...PGEDSSPSIAA.....VVASQDWPEITKYAGLvca..QAHRQELIQDLFKEw1
  35 FGADVTHph...PGEDSSPSIAA.....VVASQDWPEVTKYSGLvca..QAHRQEIIQDLYTTw1
  36 IGLDVGRmp6nlPGSLNVCASVR.....LYGKQGEFVRCRVEDSl....TEGEEIPQRILENC..
  37 IGLDVGRmp6nlPGSLNVCASVR.....LYGKQGEFVRCRVEDSl....TEGEEIPQRILENC..
  38 FGADVTHph...PGEDSSPSIAA.....VVASQDWPEITKYAGLvca..QAHRQELIQDLFKEw1
  39 --MSHTP.....PGEDSASSIAA.....VVASMDWPEITKYRGLvsa..QSHRQEIIEDLFSVg1
  40 IGLDVCR.....ENNMSTAGLIQ.....VIGKDGRVLKSKTISSh....QSGEKIQINILKDI..
  41 FGADVTHph...PGEDSSPSIAA.....VVASQDWPEITKYAGLvca..QAHRQELIQDLFKQw1
  42 FGADVTHsp...PGEDSASSIAA.....VVASMDWPEITKYRGLvsa..QSHRQEIIEDLFSVg1
  43 VGIDISRitrd.GKTVNAVAFTK.....IFNSKGELVRYYLTSY.....PAFGEKLTE---KA..
  44 VGIDISRitrd.GKTVNAVAFTK.....IFNSKGELVRYYLTSY.....PAFGEKLTE---KA..
  45 CGVDIF-.....-SKHGKKNQLA.....FCSTTDKYFSRYYSQV.....ISSGEFSI-HLQQA..
  46 IGLDISRtp6rkSGSLNVCASVR.....LYGKYGEFIRYRLEDA.....LTQGEEIDK-----..
  47 IGFDAGR.....NETLSYGTSSF.....AVLADGQILGWELPEA.....QKGEILDPDHVRRT..
  48 IGLDLGGv....--SQRAPGLAF.....LFTREGAQLGWQLAEA.....QRGERVEDAVLGDL..
  49 VGADVTHps...PDQSNIPSIAA.....VTASMDTKCYIYNIELsi...QTPKKEMIVQFEDI..
  50 VGLDVSH.....ENGKHAAGIIQ.....IIGKDGAMIKQKALSTs....EAGEKISSETMREI..
  51 MGLDTGLgi...FGNHRVGGCTV.....VYDSEGKIRRIQPIETp....APGERLHLPYVIEY..
  52 IGISFYRdv...SGQQLWTSAAQ.....MFDERGRGFILKGKRAqtesrGRHPYMTEEDAYEL..
  53 VGIDVTHpgp..NSREGTPSIAA.....VVANVDDNFVQFPASLriq..QHSKKEMLDELRDM..
  54 LGIGFYRdl...DGQQLWTSTAQ.....MFDERGRGLILRGARAqtetrGRHPYLTAKDAEDL..
  55 IGVSFYRea...GGQQLFTSAAQ.....MFDERGRGFILKGKGAqtesrGRHPYLTQDDAKTL..
  56 LGIGFHRsl...DGQQLWTSTAQ.....MFDETGHGLILRGARAqtetrGRRPYLTRADMKAL..
  57 IGISFFKda...ETDEIWTSAAQ.....MFDERGRGFILRGGPAqsesrGRHPFLTIDEAHKL..
  58 IGIDYAMrrvqdDGPRFAICCAQ.....VFDAEGSGLEFIAYKAdg6vyGDNPYLNHAQMLKI..
  59 VGISFYRsl...DQATLVTSMAQ.....VYDERGEGVIVRGKAVellkdDRQPHLSRNDAYLL..
  60 VGIDVAHpp...AGAAVTASIAA.....MVASIDSNLAQWPGEIgiq..SQARKEQVDALTSM..
  61 AGIGYSIkkqysGKAEVVLGCSH.....IYNAQGQGLRYKLSKVeh7dkKKNPYLNFEEAYKF..
  62 AGIGYSVktngkGKVDIVLGCSH.....IYNAKGQGLRYKLSKVeq7dgKKNPYLTYEEAFKF..
  63 IGISYAVrppdsGRSRFVTCCSQ.....VFDAEGSGLEFVAYDAhe6vqRENPFLSRTEMFRV..
  64 IGLSYALrptesDRPRFVTCCSQ.....VFDAEGAGLEFVAYDAhe6vqRDNPFMSRTEMFRV..
  65 LGADVTHptg..EINSESVSIAS.....IVGSEDGIFNKFPGSVri...QTGGQEVIADVKSM..
  66 LGADVTHptg..ESNEESVSIAS.....VVGSEDAIFNSFPGSLrv...QGGGQEVIAEIKDM..
  67 IGLAYALkrvn.DETHFVTCCSQ.....VFDMDGGGMQFVAFEAk10eaRRNPFLSREDMRAV..
  68 VGISFFNek...GKETRRASLAQ.....IFLDTGESFVLRGDSFnw7khPKSPHLSKDDAYNL..
  69 IGIGSAHvk6rlTEPERVVGITT.....VFSADGNYLLWNTSRE.....ADYDDYPRELLLSLrd
  70 VAFDVQL.....N-----TACFT.....FIGKSGSDIRTVLKTS.....NQKERLSKAQVRQT..


              530        540            550       560             570  
               |          |              |         |               |  
   1 ...LEETLWAFRRKA.GRLPSRVLLLRDGR.....VPQDEFALALEALAREG.....IAY.DLVS
   2 ...LVDALTHYLRSN.GQLPDRIIIYRDGVgd7klLQQYEIPQMKICFTILGsnyq.PTL.TYVV
   3 ...LVDALTHYLRSN.GQLPDRIIIYRDGVgd7klLQQYEIPQMKICFTILGsnyq.PTL.TYVV
   4 ...MAKALRQYQREH.QKLPTRILFYRDGVss7kqLFEYEVKDIVEKLDIEYkr7gpPML.AYIV
   5 ...LEETLWAFRRKA.GRLPSRVLLLRDGR.....VPQDEFALALEALAREG.....IAY.DLVS
   6 ...LEETLWAFRRKA.GRLPSRVLLLRDGR.....VPQDEFALALEALAREG.....IAY.DLVS
   7 ...IAKALRQYQREH.HKLPTRIMFYRDGVsp7kqLFEFEVKEIVEKLDAEYkr7gpPML.AYIV
   8 ...IAKALRQYQREH.KKLPSRIVFYRDGVss7kqLFEFEVKDIVEKLKAEYar7spPQL.AYIV
   9 ...LEKTLQAYQRRN.CHLPDRIIIFRDGVsd7niCLDYEIPQLQAACKLVQpdye.PKI.TFIV
  10 ...LVSAINVYREKN.GQYPDRIFIYRDGVgd7etVKNYEVRQFLNTCARLDpayk.PKL.SVII
  11 ...FEIALKMYRKRN.GKLPTNIIIYRDGIgd7ytCLNYEIPQFEMVCGNR-.....IKI.SYIV
  12 ...VSKLIIKFYQIC.QRYPQKLLLMRDGL.....VQEGEFQQTIELLKERK.....IAV.DVIS
  13 ...VSKLIIKFYQIC.QRYPQKLLLMRDGL.....VQEGEFQQTIELLKERK.....IAV.DVIS
  14 ...VKSLESFTSDNR.TPLPSRIIIFRDGVsn7ktVIETEVAQFRQAIEQVKka8kpIKL.VVLS
  15 ...VKSLQSFCGDRN.GPLPSRIIIFRDGVsn7ktVIETEVAQFRQAIEQVKte8kpIKL.IVLS
  16 3glIREHFIAFRRAT.GQIPQRIIFYRDGVse7sqVLLHEMTAIRKACNSLQenyv.PRV.TFVI
  17 3glIREHFIAFRRAT.GQIPQRIIFYRDGVse7sqVLLHEMTAIRKACNSLQenyv.PRV.TFVI
  18 ...VSKLVLKFQDNY.DSYPKKILLMRDGL.....VQDGEFEQTIRELTHQG.....IDV.DILS
  19 2gmIRELLIAFRKKT.GRRPERIIFYRDGVse7shVLLHEMDAIRKACASLEegyl.PPV.TFVV
  20 ...VKSLQSFCGDRN.GPLPSRIIIFRDGVsn7ktVIETEVAQFRQAIEQVKte8kpIKL.IVLS
  21 ...LGNAVMEFYKVNkNRLPSKIIIYRDGVge7pfVYDYEVTQVRDSLSKIYarpehIKL.AFII
  22 3gmIRELLIAFRRST.GYKPSRIIFYRDGVse7sqVLLHEMDSIRKACASLEegyl.PPV.TFVV
  23 ...VSKLVDRFYDKL.SRYPSKVLLMRDGL.....VQGGEFSRTIEELEKEK.....IAV.DIVG
  24 ...LEAALKLWCKHN.QFLPQAIIVYRDGVgd7qaLMDHEVPQIESSLRSVYpkdsgVKL.TFIV
  25 2gmIRELLIAFRKKT.GRRPERIIFYRDGVse7shVLLHEMDAIRKACASLEegyl.PPV.TFVV
  26 ...VSKLVNRFYNKF.HRYPRKVLLMRDGL.....VQRGEFDKTIEELRKEK.....IAV.DIVG
  27 2gmIRELLIAFRKKT.GRRPERIIFYRDGVse7shVLLHEMDAIRKACASLEegyl.PPV.TFVV
  28 2gmIRELLIAFRKKT.GRRPERIIFYRDGVse7shVLLHEMDAIRKACASLEegyl.PPV.TFVV
  29 ...MVDKFKEFN--I.KLDNKKILLLRDGR.....ITNNEEEGLKYISEMFD.....IEV.VTMD
  30 ...MVDKFKEFN--I.KLDNKKILLLRDGR.....ITNNEEEGLKYISEMFD.....IEV.VTMD
  31 3gmIKELLISFRRAT.GQKPQRIIFYRDGVse7yqVLLYELDAIRKACASLEpnyq.PPV.TFVV
  32 2gmIREFLIAFRKKT.GRRPERIIFYRDGVse7srVLLHEMDAIRKACASLEegyl.PPV.TFVV
  33 ...XVDKFKEFN--I.KLDNKKILLLRDGR.....ITNNEEEGLKYISEXFD.....IEV.VTXD
  34 3gmIKELLIAFRRST.GHKPLRIIFYRDGVse7yqVLLYELDAIRKACASLEagyq.PPV.TFVV
  35 3gmIKELLMSFRRAT.GQKPQRIIFYRDGVse7yqVLLYELDAIRKACAALEpnyq.PPV.TFVV
  36 ...LPQA--------.ELKNQTVLIYRDGK.....FQGKEVENLLARARAIN.....AKF.ILVE
  37 ...LPQA--------.ELKNQTVLIYRDGK.....FQGKEVDNLLARARAIN.....AKF.ILVE
  38 3gmIKELLIAFRRST.GHKPLRIIFYRDGVse7yqVLLYELDAIRKACASLEagyq.PPV.TFVV
  39 2gmIREFLIAFRKKT.GRRPERIIFYRDGVse7srVLLHEMDAIRKACASLEegyl.PPV.TFVV
  40 ...IFEAKQAYKNTY.NKKLEHIVFHRDGI.....NRED-IDLLKEITNSLE.....IKF.DYVE
  41 3gmIKELLISFRRAT.GQKPQRIIFYRDGVse7yqVLLFELDAIRKACASLEpnyq.PTV.TFVV
  42 2gmIREFLIAFRKKT.GRRPERIIFYRDGVse7srVLLHEMDAIRKACASLEegyl.PPV.TFVV
  43 ...IGDVFSLLEKLG.FKKGSKIVVHRDGR.....LYRDEVAAFKKYGELYG.....YSL.ELLE
  44 ...IGDVFSLLEKLG.FKKGSKIVVHRDGR.....LYRDEVAAFKKYGELYG.....YSL.ELLE
  45 ...LKASLQAFKQQN.NVYPTQIIIYRDGVge7ptVLGNELPQFQQAIVELGlrdq.TKL.TFVI
  46 ...--RTLERFLPAA.DLSGKTVLIYRDGR.....FCGDEIKHLRERAKAMG.....SKF.ILVE
  47 ...VRRIISQFQKMNgKQSPKRILLMRDGL.....IQQQEFSLITEALEEGE.....IKY.DLIS
  48 ...LERSLQAYRQVHlGALPRRIALHRDGR.....LFES-LDVIRNFERDYS.....VRV.DVLE
  49 ...MVDHFHAFKKSQ.GILPKKVFVFRDGVse7aeVMKSELTGLHRAYQRVAglnakPEV.LFIL
  50 ...VYDTLHAFEEQY.GHAPKHITFHRDG-.....FGREDLTLIDSILSPRE.....IQF.DYVE
  51 ...LEN-----KANI.DMENKNILFLRDGF.....IQNSERNDLKEISKELN.....SNI.EVIS
  52 ...VKGALKAYRDHH.KHSPARVIILKTSR.....FRDDEADGILRALEEAE.....TELrDLVW
  53 ...LVERLIVYEKKN.KGLPARIFVFRDGVse7dtVLQEELAQILEAFKKLSt14siIIC.GFYP
  54 ...VVQSIAAYKAHH.RHVPARLVVLKTSR.....FRSEEAEGIDAALGKSG.....IEMsDLVW
  55 ...IADALAAYKKHH.MNYPARVIVLKTSR.....FRDEEADGIFEALDEVG.....TELrDLVW
  56 ...VLDALRSYKEHH.KALPARLVVLKTSH.....FRDEEADGVDDALEELDv....SMC.DMVW
  57 ...TESALAAYKSVH.RTMPARVIVMKTSR.....FREDEAEGVGKALDEAG.....VELrDLVW
  58 ...IARSLTIYQRKHyGDLPKRVVIHKNTP.....FRDEEVDGCLNALSSVD.....-AV.ELIQ
  59 ...LTTALKEYRREH.RHLPARVVVHKSSK.....YSKDELEGFNGAVDDQG.....LET.ADFM
  60 ...LQSRLRIWKAKNkDALPENILVYRDGVsk7amVQGMEIPLLEKACELEYrgrkmPNM.TVVV
  61 ...GMDILALFQDAM.EKLPQRVVVHKRTP.....FKNDEIKGITNALKQAGi....SEI.DLIT
  62 ...GITIRELFVKSM.DKLPRRVVIHKRTP.....FRNEEIEGITHALSQAGi....KDI.DLIT
  63 ...MTRSVDLYRRRHaGRSPRRVMVHKTTE.....FKQDEIDGCMEALHLCE.....-AV.DLVQ
  64 ...MGRSLDLYRRRHsGRSPRRVTVHKTTE.....FKKDEIDGCMEALHLCE.....-AV.DLVQ
  65 ...VLERLENFHKKI.GKLPSKVLFYRDGVse7ttILKEELTKIKAAFNEYGkl9ysPTI.TFMI
  66 ...VYERLENFHKKV.GKLPSKVLFYRDGVse7ytVLKEELPKVKAAFSEYGka8fnPKI.TFMI
  67 ...IARSLSIYQQRNgGILPRRMVIHKSNA.....FKEDEVLGARDALTAV-.....PEV.ECIE
  68 ...MNYVLEHYRSIR.RQNPNRVVVHKSSN.....FWNDELEGFREATKNV-.....PQK.DFIT
  69 ...CIDTIKNRNAWQ.AGDELRLVFHVFKP.....LKDVEATAVKKLVEGLTqtyakVEF.AFVH
  70 ...LLEVLRQEVGFG.RRTMQTIVVQRDGK.....LFASEIAGAKDAIEIVKke8sdVSL.NFIE


           580            590       600            610            620  
            |              |         |              |              |  
   1 VRKSGGGRVYPVQ.....GRLADGLYVPLEDKTFLLLTVH.....RDFRGT.....PRPLKLVH.
   2 VQKRINTRIFLKSrd8pnPGTVVDHCITRRDWYDFLIVSQ.....KVTQGT.....VTPTHYVV.
   3 VQKRINTRIFLKSrd8pnPGTVVDHCITRRDWYDFLIVSQ.....KVTQGT.....VTPTHYVV.
   4 VTKSSNTRFFRNGrnpp.PGTVVDNIVTLPERYDFYLVSQ.....AGRQGT.....VSPTGYNV.
   5 VRKSGGGRVYPVQ.....GRLADGLYVPLEDKTFLLLTVH.....RDFRGT.....PRPLKLVH.
   6 VRKSGGGRVYPVQ.....GRLADGLYVPLEDKTFLLLTVH.....RDFRGT.....PRPLKLVH.
   7 VTKSMNTRFFNNGrnpp.PGTVVDDVVTLPERYDFYLVSQ.....QVRQGS.....VSPTSYNV.
   8 VTRSMNSRFFLNGqnpp.PGTVVDDVITLPERYDFYLVSQ.....QVRQGT.....VSPTSYNV.
   9 VQKRIITRLFTMSr13apPGTVLDNTVTRRYMFDFFLVSQ.....TVQMGT.....VTPTHYIV.
  10 VQKRVNTRIFEKKrq7ppPGTVVDSTITRRFLYDFYLVPQ.....LVRQGT.....VTPTHYIV.
  11 VQKRINTRIFSGSgi8plPGTVVDQHITKSNMYDFFLVSQ.....LVRQGT.....VTPTHYVV.
  12 VRKSGAGRMGQEIye8vyRDAAIGSVILQPAERSFIMVTSqpv..SKTIGS.....IRPLRIVH.
  13 VRKSGAGRMGQEIye8vyRDAAIGSVILQPAERSFIMVTSqpv..SKTIGS.....IRPLRIVH.
  14 VNKKVGAKFYAGErn7psQGTLIDSEIC-NGKDGFYLIAQ.....KTTQGT.....VQPTYYHV.
  15 VNKKVGAKFYAGErn7ppQGTLIDTEIS-NGKDDYYLISQ.....RTTQGT.....VQPTHYHV.
  16 VQKRHHTRLFPEQh14iqPGTVVDTKICHPNEFDFYLNSH.....AGIQGT.....SRPAHYHV.
  17 VQKRHHTRLFPEQh14iqPGTVVDTKICHPNEFDFYLNSH.....AGIQGT.....SRPAHYHV.
  18 VRKSGSGRMGRELts9tyDDAEVGTVIFYSATDSFILQTTev6tkTGPLGS.....ARPLRVVR.
  19 VQKRHHTRLFPEVh14ilPGTVVDRQICHPTEFDFYLCSH.....AGIQGT.....SRPTHYHV.
  20 VNKKVGAKFYAGErn7ppQGTLIDTEIS-NGKDDYYLISQ.....RTTQGT.....VQPTHYHV.
  21 VTKRLNTRFFLNKnnpp.AGTVIDDVITDPLKYDFFIVSQ.....AVRQGT.....VAPTAYNV.
  22 VQKRHHTRFFPSDh14ilPGTVVDTKICHPTEFDFYLNSH.....AGIQGT.....SRPTHYHV.
  23 IRKSGTGRMGIEEgkgkyKDAKIGTVVFDYSRKSFTLITSqp6kgGNSLGS.....ARPLRAIH.
  24 VKKRINTRFFVESqg8plPGTVIDVEVTKRQWYDFFIVSQ.....SVKDGT.....VTPTHYNV.
  25 VQKRHHTRLFPEVh14ilPGTVVDRQICHPTEFDFYLCSH.....AGIQGT.....SRPTHYHV.
  26 VRKSGTVRMGREEkgsy.RDAAMGTVIFDHERRSFMLVTSqp6ksSVPIGS.....ARPLRVVH.
  27 VQKRHHTRLFPEVh14ilPGTVVDRQICHPTEFDFYLCSH.....AGIQGT.....SRPTHYHV.
  28 VQKRHHTRLFPEVh14ilPGTVVDRQICHPTEFDFYLCSH.....AGIQGT.....SRPTHYHV.
  29 VIKNHPVRAFAN-.....----MKMYFNLGGAIYLIPHKL.....KQAKGT.....PIPIKLAKk
  30 VIKNHPVRAFAN-.....----MKMYFNLGGAIYLIPHKL.....KQAKGT.....PIPIKLAKk
  31 VQKRHHTRLFANNh14ilPGTVVDSKICHPTEFDFYLCSH.....AGIQGT.....SRPAHYHV.
  32 VQKRHHTRLFPEVh14ilPGTVKDRQICHPTEFYFYLCSH.....AGIQGT.....SRPTHYHV.
  33 VIKNHPVRAFAN-.....----XKXYFNLGGAIYLIPHKL.....KQAKGT.....PIPIKLAKk
  34 VQKRHHTRLFAQNh14ilPGTVVDSKICHPTEFDFYLCSH.....AGIQGT.....SRPAHYHV.
  35 VQKRHHTRLFANNh14ilPGTVVDSKICHPTEFDFYLCSH.....AGIQGT.....SRPAHYHV.
  36 CYKTGIPRLYNLQqkqi.NAPSKGLALALSNREVILITSQv....SEQIGV.....PRPLRLKV.
  37 CYKTGIPRLYNFEqkqi.NAPSKGLAFALSKREVILITSQv....SEQIGV.....PRPLRLKV.
  38 VQKRHHTRLFAQNh14ilPGTVVDSKICHPTEFDFYLCSH.....AGIQGT.....SRPAHYHV.
  39 VQKRHHTRLFPEVh14ilPGTVKDRQICHPTEFYFYLCSH.....AGIQGT.....SRPTHYHV.
  40 VTKNINRRMAMLEk15kkWITEIGMCLKKENEAYLITTNP.....SENMGM.....ARPLRIKK.
  41 VQKRHHTRLFASDh14ilPGTVVDSNICHPTEFDFYLCSH.....AGIQGT.....SRPAHYHV.
  42 VQKRHHTRLFPEVh14ilPGTVKDRQICHPTEFYFYLCSH.....AGIQGT.....SRPTHYHV.
  43 IIKRNNPRFFSNE.....-KFIKGYFYKLSEDSVILATYN.....QVYEGT.....HQPIKVRK.
  44 IIKRNNPRFFSNE.....-KFIKGYFYKLSEDSVILATYN.....QVYEGT.....HQPIKVRK.
  45 CNKRVSGKFYTGGqt9lpGTYVDNPKVVDNEGKEFYLISQ.....MSRSGT.....VTPTLYKI.
  46 CIKSGIPRLYEVQe12ilKAPPKGLALRLSSHEVMLVTTEvk...SEKMGL.....PNPLRLKV.
  47 VRKSGAGRIGRRNsdgtyVDAPKGTVIFSGNDKFKIVTSE.....AKAGGS.....ARPLFVVR.
  48 VVKSGCPPLYRRGvv9afRNPEVGDAFELPGLDELIIATYsg8ssWGDKVT.....VRPLRLRK.
  49 VQKRHHTRFFLPGnn8vdPGTVVDRDIVHPRELDFYLVSH.....QAIKGT.....ARPTRYHA.
  50 ILKNINRRMAIHEde...WKTSQGLSYTKERMGYLLSTNP.....HARVGM.....AKPLKVVQ.
  51 IRKNNKYKVFTSDyri..GSVFGNDGIFLPHKTPF--GSN.....PVKLST.....WLRFNCGN.
  52 VQESYDAKILRDGd....YPVLRGTFVDLDGKGLLYTNGS.....IPYYGTyp6yvPRPLLLCP.
  53 IDSQYADRNGNTR.....PGTVVDKGVTGVFDFDFYLQAH.....AGLQGS.....VKATHYTV.
  54 VQESSPIAIFRDGn....YPVLRGTFVDLDGKGLLYTRGS.....VPFYGTfp6rvPRPLLLVP.
  55 VQESSFVKVFRDGn....YPVMRGTFVKLDGKGLLYTNGS.....IPYYGTyp6ydPKPLLICP.
  56 VQESSPISLLRNGs....YPVLRGTFVELDGKGLLYTRGSvp6stYPGMRV.....PNPLLLCP.
  57 IHESYSVKVLRDGd....FPVLRGTFVELDGNGLLYTNGS.....IPYYGTyp6yvPNPLLLCP.
  58 VQQDTGWRGYRVDaa7agYPVERGSLMPIGAHEALLWSRGd13yfKEGKGT.....PEPLLITR.
  59 VVTKSFTRLFREGt....YPPLRGTMLSLDEANHLLYTRGsv7atYPGMYV.....PRPLKFQI.
  60 VGKRHHTRFYPTSt12vaPGTVVDRGITEAHTWDFFLQSH.....EALKGT.....GRPAHYIVv
  61 ITQEYDLKFIAEKi10dgYPVDRGTCIKLSSRNALLWTHGv12yyQGGRCI.....PAPLKITK.
  62 INYEYNAKFIAQRv10dsYPVSRGTCIKLSSRNALLWTHGv12yyPGGRCI.....PAPLKITK.
  63 IVEDVGWRGIRIDl12asFPVSRGTLIGLGSREALLWTHGd12yfQGARST.....PRPLRLVR.
  64 VVEDIGWRGVRIDr12tgYPVDRGTLIPLGDRECLLWMHGd11yyQGSRST.....PRPIRLVR.
  65 VVKRHHTRFIPIHd21viAGTTVDREITSPAYFDFYVQSQ.....QSLQGT.....GIPAHYYV.
  66 VVKRHQTRFIPLSe21viPGTVVDRDITSIAFFDFYIQSQ.....QALQGT.....GIPAHYYV.
  67 ISSRPTWRGVWLVk13arYPVPRGTFVPRSGTSALLWAAGn12yyQGGKSI.....PRPLLLTR.
  68 ILESSLKLFTQGR.....YPILRGTLLSLEDDTSGFLFSTgf8ntYPGFSI.....PRALEIRP.
  69 VSTDHDWVMFDRTs16ghYVPERGHAVPMGKRELLVAVGGpmdlkSALHGV.....PKPLLLKL.
  70 IPKSSVAPFRLFDs11maNNPRIGSYFIATNYDGYICTTGke...FYHPGT.....ANPLHVKY.


                     630       640            650       660       670  
                      |         |              |         |         |  
   1 ....EAGD.....TPLEALAHQIFHLTRLYPASGFA.....FPRLPAPLHLADRLVKEVGRLG.I
   2 ....VYDDsg...ITPDQCQRLTYKMCHLYYNWP-G.....TVRVPAPCQYAHKLSYLVGQCV.H
   3 ....VYDDsg...ITPDQCQRLTYKMCHLYYNWP-G.....TVRVPAPCQYAHKLSYLVGQCV.H
   4 ....LYSNir...LSPDQIQKLTYKMCHLYYNWS-G.....TTRVPAVCQYAKKLATFVGTHL.H
   5 ....EAGD.....TPLEALAHQIFHLTRLYPASGFA.....FPRLPAPLHLADRLVKEVGRLG.I
   6 ....EAGD.....TPLEALAHQIFHLTRLYPASGFA.....FPRLPAPLHLADRLVKEVGRLG.I
   7 ....LYSNir...LSPDQIQKLTYKMCHLYYNWS-G.....TTRVPAVCQYAKKLATLVATNL.H
   8 ....LYSTmg...ISPEKMQKLTYKMCHLYYNWS-G.....TTRVPAVCQYAKKLATLVGTNL.H
   9 ....LRDDsk...FSPDILQQLSYKMCYMYYNWT-G.....TIRVPACCQYAHKLAYLVGQSV.K
  10 ....LHDGgd...VKTDHMQRFTYKLCHLYYNWP-G.....TIRVPAPCQYAHKLAYLVGQSI.K
  11 ....LRDDcn...YGPDIIQKLSYKLCFLYYNWA-G.....TVRIPACCMYAHKLAYLIGQSI.Q
  12 ....EYGS.....TDLELLALQTYHLTQLHPASGFR.....SCRLPWVLHLADRSSKEFQRIG.Q
  13 ....EYGS.....TDLELLALQTYHLTQLHPASGFR.....SCRLPWVLHLADRSSKEFQRIG.Q
  14 ....LVNDlidepNITNKLQALAYKLCYMYYNFS-G.....AIKIPAPIQYAHVCSNFIGD--.-
  15 ....LVNDmsdepNILKKLQSLSYKLCYMYYNFS-G.....AIKIPAPIQYAHVCSNFIGDR-.-
  16 ....LLDEng...FTADQLQMLTNNLCYTYARCTKS.....VSIVP-PAYYAHLAAFRARYYM.E
  17 ....LLDEng...FTADQLQMLTNNLCYTYARCTKS.....VSIVP-PAYYAHLAAFRARYYM.E
  18 ....HYGN.....TPLELLALQTYHLTQLHPASGFR.....SCRLPWVLHLADRSSKEFQRIG.Q
  19 ....LYDEnh...FTADALQSLTNNLCYTYARCTRA.....VSVVP-PAYYAHLAAFRARYYV.E
  20 ....LVNDlfdepNILKKLQALSYKLCYMYYNFS-G.....AIKIPAPIQYAHVCSNFIGDR-.-
  21 ....LQDStg...LKADQMQRLTYKLCHMYYNFS-G.....TVRVPAPCQYAHKLAFFVSQTI.K
  22 ....LYDEnk...FTADILQILTNNLCYTYARCTRS.....VSIVP-PAYYAHLAAFRARYYI.E
  23 ....EHGK.....TPLEVLALQTYHLSQLHPASGFQ.....ACRLPWVLHFADKSGKEFQRLG.D
  24 ....IHDTvc...FTPDRIQYLTYRLCHMYYNLP-G.....VIRVPAPCHYAHKLAYLVGQSI.H
  25 ....LYDEnh...FTADALQSLTNNLCYTYARCTRA.....VSVVP-PAYYAHLAAFRARYYV.E
  26 ....EHGN.....TPLEVLAIQTYHLSQLHPASGFQ.....ACRLPWVLHFADKSSKEFQRIG.N
  27 ....LYDEnh...FTADALQSLTNNLCYTYARCTRAv18ivSVYFP-PAYYAHLAAFRARYYV.E
  28 ....LYDEnh...FTADALQSLTNNLCYTYARCTRAv18ivSVYFP-PAYYAHLAAFRARYYV.E
  29 r8gkVEKQ.....SITRQDVLDIFILTRLNYGSISA.....DMRLPAPVHYAHKFANAIRNEW.K
  30 r8gkVEKQ.....SITRQDVLDIFILTRLNYGSISA.....DMRLPAPVHYAHKFANAIRNEW.K
  31 ....LWDEnk...FTADGLQSLTNNLCYTYARCTRS.....VSIVP-PAYYAHLAAFRARFYM.E
  32 ....LYDEnh...FTADELQTLTNNLCYIYARCTHA.....VSVVP-PAYYSHLAASHAHCCI.K
  33 r8gkVEKQ.....SITRQDVLDIFILTRLNYGSISA.....DXRLPAPVHYAHKFANAIRNEW.K
  34 ....LWDEnn...FTADGLQSLTNNLCYTYARCTRS.....VSIVP-PAYYAHLAAFRARFYM.E
  35 ....LWDEnk...FSADGLQSLTNNLCYTYARCTRS.....VSIVP-PAYYAHLAAFRARFYM.E
  36 ....HELGeq...RNLKQLVDTTLKLTLLHYGSL-K.....DPRLPIPLYGADIIAYRRLQGI.Y
  37 ....HELGdq...VNLKQLVDTTLKLTLLHYGSL-K.....EPRLPIPLYGADAIAYRRLQGI.C
  38 ....LWDEnn...FTADGLQSLTNNLCYTYARCTRS.....VSIVP-PAYYAHLAAFRARFYM.E
  39 ....LYDEnh...FTADELQTLTNNLCYIYARCTHA.....VSVVP-PAYYSHLAASHAHCCI.K
  40 ....VYGN.....QNMDDIVKDIYKLSFMHIGSI-M.....KSRLPITTYYADLSSIYSHREL.M
  41 ....LWDEnk...FSADELQSLSNNLCYTYARCTRS.....VSIVP-PAYYAHLAAFRARFYM.E
  42 ....LYDEnh...FTADELQTLTNNLCYIYARCTHA.....VSVVP-PAYYSHLAASHAHCCI.K
  43 ....VYGE.....LPVEVLCSQILSLTLMNYSSF-Q.....PIKLPATVHYSDKITKLMLRGI.E
  44 ....VYGE.....LPVEVLCSQILSLTLXNYSSF-Q.....PIKLPATVHYSDKITKLXLRGI.E
  45 ....IHNDvq...GNENDIKVLTFKLCWLYYNFT-G.....PIKIPAPVRYAHCLCNFIGD--.-
  46 ....IPEEgqq..VSLESLVEATLKLTLLHHGSL-K.....EPRLPIPLYGSDIIAYRRLQGI.S
  47 ....EQGD.....TPIEIIAEQFYRLTQLHPVSGSF.....TSRLPMPLNYADKLAKKIQSLGsV
  48 ....RYGE.....TDLHTLARQVVLLSRIHGASLYR.....HPRLPVTTHHADRFATLRQECN.L
  49 ....VCNDgr...IPENEVEHLAYYLCHLYARCM-R.....AVSYPAPTYYAHLACLRARSLT.Y
  50 ....QTTT.....LPFEAILTDVYRLSFMHVHSL-L.....KTRLPITTHYADLSSTFHNRGL.L
  51 ....EEGL.....KINESIMQLLYDLTKMNYSALYGegr..YLRIPAPIHYADKFVKALGKNW.K
  52 ....HPSSd....STAAQIAEEVFSLTKINWNSTQM.....NQRLPVPIRAARKVGEVLKYIP.D
  53 ....VYDEns...LTADDIQQGTHTASYLYARATKA.....VSLIP-AAYYADLACERGRCYL.N
  54 ....HENSd....STILTLAKDVLALTKVNWNTTQF.....DQKLPAPIKAAREVGRILKHVE.F
  55 ....YKTSd....STVAQIANEIFGLTKINWNSTQM.....NQKLPIPIRAARKVGEVLKYIT.D
  56 ....HKQTd....RSITQIAEEILALTKVNWNSTQF.....DQKLPAPIRASREVGRVLKHVA.Q
  57 ....HPQSe....STIEQIAKEVFSLTKVNWNSTQM.....NQRLPIPIRAARKVGDVLKYVP.S
  58 ....HAGR.....GDFGDVCSDTLGLTKMDWNNDGP.....YDGMPVTLNYAGRLAQIVKRMP.D
  59 ....AQAD.....TSPRKLAEEILALTKLNWNNTQF.....DGAEPITMRVAQQVGKVLKYVP.E
  60 58tg---Gaql..NEVDTLEMLTYSLCNVFGRAT-R.....SVSYATPAYFADILCERGRC--.-
  61 ....YYGH.....GDLETIAKEILGFTKMNWNSFNL.....YTKLPATIDTSNTLAQVGNLLR.Q
  62 ....YYGK.....GDLSTIASEIIGFTKMNWNSFNL.....YTKLPATIDTSNTLAQVGNLLH.Q
  63 ....HAGH.....GSWDEAALAILALTKMNWNNDAL.....YDPLPVTIGYSKVLARVVKRMS.G
  64 ....HAGQ.....GPWDETARSALALAKMDWNNDAL.....YDMLPVTMAYAKTLARVVKRMD.G
  65 ....LHDEnn...YTSDTIQKITYDLCHTFSRATKS.....VKVVP-AAYYADLLCTRGRDYI.Y
  66 ....LHDEns...YTSDEIQRITYNLCHTFGRATKS.....VKVVP-AAYYADLLCTRGRCYV.G
  67 ....HAGS.....GPLETIAHETLALTKMDWNNDAL.....YDPVPVSIRYSQKLARTISNVQ.D
  68 ....FNLD.....TSLVQVCKEILSFTKLDWNNTFV.....YSRMPVTISVSRKVGQVMSETE.A
  69 ....HPQStf...TDIEYLGRQAFRFTSMSWRNM-Y.....PSRNPVTISYSDLIAELLGHLR.H
  70 ....IEGN.....MPFEKILEDVYALTCLALTRPED.....CTREPFTMKLAD----------.-


            680     
             |     
   1 RHLKEVDREKLFFV
   2 AQPSDVLVDKLFFL
   3 AQPSDVLVDKLFFL
   4 SIPQNALEKKFYYL
   5 RHLKEVDREKLFFV
   6 RHLKEVDREKLFFV
   7 AIPQNALEKKFYYL
   8 SIPQNALEKKFYYL
   9 RMPAESLNDKLFYL
  10 SEPSHELNNLLYYL
  11 RDVAEALSEKLFYL
  12 IS------------
  13 IS------------
  14 --------------
  15 --------------
  16 SEMSDGG-------
  17 SEMSDGG-------
  18 ISL-----------
  19 GESSDGG-------
  20 --------------
  21 QPAHPQLSTTLYFL
  22 GDTSDSGS------
  23 N-------------
  24 QEPHHSLASRLFYL
  25 GESSDGG-------
  26 --------------
  27 GESSDGG-------
  28 GESSDGG-------
  29 IKEEFLAEGFLYFV
  30 IKEEFLAEGFLYFV
  31 PETSDSG-------
  32 GHSSGS--------
  33 IKEEFLAEGFLYFV
  34 PETSDSG-------
  35 PDTSD---------
  36 PSLLEDDCQFW---
  37 PSLLEDDCQFW---
  38 PETSDSG-------
  39 GHSSGS--------
  40 PKSVDNNIL-----
  41 PETSDS--------
  42 GHSSGS--------
  43 PIKKEGDIMYW---
  44 PIKKEGDIXYW---
  45 --------------
  46 PGELDGDRQFW---
  47 GILQNLDRKKLFFV
  48 DDLSKMDRLCPVYL
  49 GE------------
  50 NAN-----------
  51 IDEELLKHGFLYFI
  52 GQSISSDYRRY---
  53 DFLV----------
  54 GTAVSSDFR-----
  55 EKVSS---------
  56 SGMVRADFRF----
  57 GQKVSSDYRKY---
  58 LQPHPYPVRLF---
  59 GDVVQPRYSFY---
  60 --------------
  61 YNGVTYDYRFF---
  62 YNGATYDYRYF---
  63 LGSAPYQFRFF---
  64 LGSAPYQFRFF---
  65 GFAKD---------
  66 PPSRDA--------
  67 LPGNSYPYRLF---
  68 QKFSELDSHYYFYM
  69 VRNWNA--------
  70 --------------