PFRMAT SS TARGET T0431 AUTHOR 4008-1775-0004 METHOD This file is the result of combining several RDB files, specifically METHOD T0431.t06.str2.rdb (weight 1.54425) METHOD T0431.t06.str4.rdb (weight 0.924988) METHOD T0431.t06.pb.rdb (weight 0.789901) METHOD T0431.t06.bys.rdb (weight 0.748322) METHOD T0431.t06.alpha.rdb (weight 0.678173) METHOD T0431.t04.str2.rdb (weight 1.54425) METHOD T0431.t04.str4.rdb (weight 0.924988) METHOD T0431.t04.pb.rdb (weight 0.789901) METHOD T0431.t04.bys.rdb (weight 0.748322) METHOD T0431.t04.alpha.rdb (weight 0.678173) METHOD T0431.t2k.str2.rdb (weight 1.54425) METHOD T0431.t2k.str4.rdb (weight 0.924988) METHOD T0431.t2k.pb.rdb (weight 0.789901) METHOD T0431.t2k.bys.rdb (weight 0.748322) METHOD T0431.t2k.alpha.rdb (weight 0.678173) METHOD These files were combined by translating their predictions into EHL METHOD predictions with tables generated by compare-real, and then combining METHOD those predictions with weights proportional to their mutual information METHOD with the EHL alphabet. The comments from the individual files follow. METHOD METHOD Comments from T0431.t06.str2.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t06-IDGaaH13-3-13-7-13-9-13-11-str2-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 13 (1 str2 ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t06-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 7304 METHOD METHOD ============================================ METHOD Comments from T0431.t06.str4.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t06-IDGaaH13-3-13-7-13-9-13-11-str4-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 21 (1 str4 ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t06-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 7304 METHOD METHOD ============================================ METHOD Comments from T0431.t06.pb.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t06-IDGaaH13-3-13-7-13-9-13-11-pb-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 16 (1 pb ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t06-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 7304 METHOD METHOD ============================================ METHOD Comments from T0431.t06.bys.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t06-IDGaaH13-3-13-7-13-9-13-11-bys-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 11 (1 Bystroff ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t06-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 7304 METHOD METHOD ============================================ METHOD Comments from T0431.t06.alpha.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t06-IDGaaH13-3-13-7-13-9-13-11-alpha-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 11 (1 ABCDEFGHIST ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t06-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 7304 METHOD METHOD ============================================ METHOD Comments from T0431.t04.str2.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t04-IDGaaH13-3-13-7-13-9-13-11-str2-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 13 (1 str2 ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t04-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 466.146 METHOD METHOD ============================================ METHOD Comments from T0431.t04.str4.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t04-IDGaaH13-3-13-7-13-9-13-11-str4-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 21 (1 str4 ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t04-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 466.146 METHOD METHOD ============================================ METHOD Comments from T0431.t04.pb.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t04-IDGaaH13-3-13-7-13-9-13-11-pb-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 16 (1 pb ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t04-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 466.146 METHOD METHOD ============================================ METHOD Comments from T0431.t04.bys.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t04-IDGaaH13-3-13-7-13-9-13-11-bys-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 11 (1 Bystroff ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t04-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 466.146 METHOD METHOD ============================================ METHOD Comments from T0431.t04.alpha.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t04-IDGaaH13-3-13-7-13-9-13-11-alpha-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 11 (1 ABCDEFGHIST ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t04-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 466.146 METHOD METHOD ============================================ METHOD Comments from T0431.t2k.str2.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t2k-IDGaaH13-3-13-7-13-9-13-11-str2-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 13 (1 str2 ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t2k-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 6548 METHOD METHOD ============================================ METHOD Comments from T0431.t2k.str4.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t2k-IDGaaH13-3-13-7-13-9-13-11-str4-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 21 (1 str4 ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t2k-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 6548 METHOD METHOD ============================================ METHOD Comments from T0431.t2k.pb.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t2k-IDGaaH13-3-13-7-13-9-13-11-pb-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 16 (1 pb ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t2k-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 6548 METHOD METHOD ============================================ METHOD Comments from T0431.t2k.bys.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t2k-IDGaaH13-3-13-7-13-9-13-11-bys-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 11 (1 Bystroff ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t2k-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 6548 METHOD METHOD ============================================ METHOD Comments from T0431.t2k.alpha.rdb METHOD ============================================ METHOD TARGET T0431 METHOD Using neural net dunbrack-40pc-3157-t2k-IDGaaH13-3-13-7-13-9-13-11-alpha-seeded.net METHOD This is a 4-layer network, with METHOD window units METHOD 3 13 METHOD 7 13 METHOD 9 13 METHOD 11 11 (1 ABCDEFGHIST ) METHOD The input amino acid frequencies were determined from METHOD alignment T0431.t2k-thin90.a2m.gz METHOD with weighted counts, using HenikoffWeight(1.3 bits/column, 1) METHOD The weighting was determined by the posterior distribution METHOD after regularizing with /projects/compbio/lib/recode3.20comp. METHOD Counts were regularized to probabilities using METHOD /projects/compbio/lib/recode3.20comp METHOD Total sequence weight for alignment was 6548 METHOD METHOD ============================================ MODEL 1 M E 0.38 A E 0.42 K E 0.50 K E 0.54 T E 0.47 S C 0.39 S C 0.42 R C 0.47 R C 0.51 R C 0.60 Q C 0.57 T C 0.68 G C 0.80 E C 0.75 P C 0.72 P C 0.65 L C 0.68 E C 0.64 N C 0.70 G C 0.75 L C 0.68 I C 0.62 P C 0.56 Y C 0.48 L C 0.48 G C 0.51 C H 0.43 A H 0.54 L H 0.57 Q H 0.47 F C 0.62 G C 0.74 A C 0.68 N C 0.73 P H 0.65 L H 0.83 E H 0.90 F H 0.92 L H 0.92 R H 0.92 A H 0.91 N H 0.88 Q H 0.86 R H 0.81 K H 0.67 H C 0.67 G C 0.80 H C 0.68 V E 0.58 F E 0.72 T E 0.79 C E 0.77 K E 0.70 L E 0.50 M C 0.68 G C 0.75 K C 0.64 Y E 0.54 V E 0.75 H E 0.80 F E 0.80 I E 0.72 T E 0.50 N C 0.76 P H 0.64 L H 0.81 S H 0.88 Y H 0.90 H H 0.91 K H 0.91 V H 0.89 L H 0.84 C H 0.70 H C 0.60 G C 0.75 K C 0.66 Y C 0.57 F C 0.52 D C 0.54 W C 0.49 K C 0.57 K C 0.58 F C 0.55 H C 0.52 F C 0.48 A C 0.43 T H 0.41 S H 0.40 A C 0.40 K C 0.43 A C 0.46 F C 0.61 G C 0.73 H C 0.69 R C 0.65 S C 0.57 I C 0.48 D C 0.56 P C 0.60 M C 0.60 D C 0.73 G C 0.74 N C 0.55 T C 0.44 T H 0.64 E H 0.81 N H 0.84 I H 0.86 N H 0.89 D H 0.89 T H 0.86 F H 0.79 I H 0.77 K H 0.79 T H 0.67 L H 0.52 Q C 0.50 G H 0.60 H H 0.71 A H 0.73 L H 0.80 N H 0.82 S H 0.78 L H 0.77 T H 0.84 E H 0.90 S H 0.91 M H 0.92 M H 0.92 E H 0.92 N H 0.92 L H 0.91 Q H 0.91 R H 0.90 I H 0.78 M H 0.55 R C 0.55 P C 0.60 P C 0.49 V H 0.51 S H 0.51 S H 0.51 N C 0.45 S C 0.46 K C 0.50 T C 0.54 A C 0.57 A C 0.63 W C 0.64 V C 0.61 T C 0.50 E C 0.43 G C 0.45 M H 0.72 Y H 0.84 S H 0.90 F H 0.91 C H 0.91 Y H 0.92 R H 0.92 V H 0.91 M H 0.90 F H 0.90 E H 0.89 A H 0.87 G H 0.86 Y H 0.84 L H 0.80 T H 0.72 I H 0.57 F C 0.52 G C 0.67 R C 0.61 D C 0.63 L C 0.53 T C 0.56 R C 0.54 R C 0.55 D C 0.57 T H 0.48 Q H 0.68 K H 0.80 A H 0.87 H H 0.89 I H 0.89 L H 0.89 N H 0.87 N H 0.80 L H 0.77 D H 0.76 N H 0.64 F H 0.60 K H 0.53 Q C 0.46 F C 0.51 D C 0.53 K C 0.52 V C 0.60 F C 0.67 P C 0.57 A C 0.46 L C 0.46 V C 0.48 A C 0.60 G C 0.73 L C 0.73 P C 0.66 I C 0.54 H H 0.46 M H 0.63 F H 0.74 R H 0.82 T H 0.84 A H 0.87 H H 0.90 N H 0.90 A H 0.91 R H 0.92 E H 0.92 K H 0.92 L H 0.92 A H 0.92 E H 0.92 S H 0.91 L H 0.90 R H 0.91 H H 0.90 E H 0.90 N H 0.89 L H 0.88 Q H 0.84 K H 0.75 R H 0.64 E H 0.50 S C 0.56 I H 0.57 S H 0.76 E H 0.81 L H 0.85 I H 0.89 S H 0.91 L H 0.91 R H 0.89 M H 0.88 F H 0.81 L H 0.66 N H 0.48 D C 0.56 T C 0.60 L C 0.65 S C 0.69 T C 0.70 F C 0.70 D C 0.76 D H 0.71 L H 0.86 E H 0.91 K H 0.92 A H 0.92 K H 0.92 T H 0.91 H H 0.90 L H 0.90 V H 0.89 V H 0.81 L H 0.70 W H 0.55 A H 0.43 S C 0.56 Q C 0.53 A C 0.50 N C 0.49 T H 0.59 I H 0.79 P H 0.89 A H 0.91 T H 0.92 F H 0.92 W H 0.92 S H 0.92 L H 0.92 F H 0.92 Q H 0.92 M H 0.90 I H 0.80 R H 0.62 N C 0.59 P H 0.75 E H 0.86 A H 0.91 M H 0.92 K H 0.92 A H 0.92 A H 0.92 T H 0.91 E H 0.92 E H 0.92 V H 0.91 K H 0.91 R H 0.89 T H 0.81 L H 0.65 E H 0.53 N C 0.56 A C 0.66 G C 0.71 Q C 0.59 K C 0.56 V C 0.51 S C 0.64 L C 0.53 E C 0.67 G C 0.78 N C 0.74 P C 0.69 I C 0.63 C C 0.66 L C 0.62 S C 0.75 Q H 0.71 A H 0.81 E H 0.75 L H 0.74 N H 0.56 D C 0.66 L C 0.60 P H 0.63 V H 0.81 L H 0.90 D H 0.91 S H 0.92 I H 0.92 I H 0.91 K H 0.91 E H 0.89 S H 0.83 L H 0.76 R H 0.62 L C 0.48 S C 0.63 S C 0.65 A C 0.61 S C 0.61 L C 0.54 N C 0.54 I C 0.47 R C 0.50 T E 0.48 A C 0.53 K C 0.56 E C 0.48 D C 0.52 F E 0.51 T E 0.60 L E 0.63 H E 0.53 L C 0.55 E C 0.56 D C 0.72 G C 0.79 S C 0.61 Y E 0.56 N E 0.70 I E 0.61 R C 0.58 K C 0.58 D C 0.80 D C 0.63 I E 0.65 I E 0.76 A E 0.77 L E 0.69 Y C 0.54 P H 0.42 Q H 0.55 L H 0.57 M H 0.49 H C 0.47 L C 0.58 D C 0.73 P H 0.64 E H 0.61 I C 0.50 Y C 0.65 P C 0.60 D C 0.74 P H 0.52 L C 0.49 T C 0.55 F C 0.67 K C 0.73 Y H 0.47 D H 0.59 R H 0.56 Y C 0.44 L C 0.48 D C 0.59 E C 0.51 N C 0.72 G C 0.79 K C 0.68 T C 0.56 K C 0.49 T C 0.46 T C 0.45 F C 0.41 Y C 0.42 C C 0.47 N C 0.63 G C 0.70 L C 0.62 K C 0.57 L C 0.58 K C 0.56 Y C 0.48 Y C 0.45 Y C 0.45 M C 0.59 P C 0.60 F C 0.65 G C 0.68 S C 0.64 G C 0.66 A C 0.52 T C 0.52 I C 0.55 C C 0.67 P H 0.52 G H 0.62 R H 0.82 L H 0.89 F H 0.91 A H 0.92 I H 0.92 H H 0.92 E H 0.92 I H 0.92 K H 0.92 Q H 0.92 F H 0.92 L H 0.92 I H 0.92 L H 0.92 M H 0.91 L H 0.85 S H 0.71 Y C 0.51 F C 0.52 E E 0.52 L E 0.63 E E 0.66 L E 0.53 I C 0.57 E C 0.68 G C 0.80 Q C 0.69 A C 0.61 K C 0.61 C C 0.69 P C 0.73 P C 0.63 L C 0.57 D C 0.61 Q C 0.52 S C 0.52 R C 0.52 A C 0.60 G C 0.66 L C 0.65 G C 0.70 I C 0.67 L C 0.70 P C 0.72 P C 0.67 L C 0.62 N C 0.59 D C 0.52 I E 0.59 E E 0.62 F E 0.64 K E 0.55 Y E 0.59 K E 0.56 F E 0.49 K C 0.50 H C 0.45 H C 0.53 H C 0.57 H C 0.62 H C 0.63 H C 0.68 END