a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0399
- gi|76787941|ref|YP_329852.1|_1:206 hypothetical protein SAK_1235 [Streptococcus agalactiae A909]
- gi|77414874|ref|ZP_00790984.1| putative lipoprotein [Streptococcus agalactiae 515]
- gi|76562998|gb|ABA45582.1| conserved hypothetical protein [Streptococcus agalactiae A909]
- gi|77159075|gb|EAO70276.1| putative lipoprotein [Streptococcus agalactiae 515]
- gi|22537307|ref|NP_688158.1|_1:206 lipoprotein, putative [Streptococcus agalactiae 2603V/R]
- gi|25011265|ref|NP_735660.1| hypothetical protein gbs1216 [Streptococcus agalactiae NEM316]
- gi|76798884|ref|ZP_00781091.1| lipoprotein, putative [Streptococcus agalactiae 18RS21]
- gi|77406670|ref|ZP_00783712.1| lipoprotein, putative [Streptococcus agalactiae H36B]
- gi|22534177|gb|AAN00031.1|AE014244_8 lipoprotein, putative [Streptococcus agalactiae 2603V/R]
- gi|23095689|emb|CAD46875.1| unknown [Streptococcus agalactiae NEM316]
- gi|76585753|gb|EAO62304.1| lipoprotein, putative [Streptococcus agalactiae 18RS21]
- gi|77174711|gb|EAO77538.1| lipoprotein, putative [Streptococcus agalactiae H36B]
- gi|139473649|ref|YP_001128365.1|_2:205 putative lipoprotein [Streptococcus pyogenes str. Manfredo]
- gi|134271896|emb|CAM30134.1| putative lipoprotein [Streptococcus pyogenes str. Manfredo]
- gi|94994542|ref|YP_602640.1|_2:205 phage protein [Streptococcus pyogenes MGAS10750]
- gi|94548050|gb|ABF38096.1| phage protein [Streptococcus pyogenes MGAS10750]
- gi|15675243|ref|NP_269417.1|_2:205 hypothetical protein SPy_1290 [Streptococcus pyogenes M1 GAS]
- gi|56808027|ref|ZP_00365829.1| COG2352: Phosphoenolpyruvate carboxylase [Streptococcus pyogenes M49 591]
- gi|71903700|ref|YP_280503.1| hypothetical protein M28_Spy1035 [Streptococcus pyogenes MGAS6180]
- gi|71910867|ref|YP_282417.1| hypothetical protein M5005_Spy_1054 [Streptococcus pyogenes phage 5005.1]
- gi|94988730|ref|YP_596831.1| phage protein [Streptococcus pyogenes MGAS9429]
- gi|94990619|ref|YP_598719.1| phage protein [Streptococcus pyogenes MGAS10270]
- gi|94992553|ref|YP_600652.1| phage protein [Streptococcus pyogenes MGAS2096]
- gi|13622414|gb|AAK34138.1| hypothetical protein SPy_1290 [Streptococcus pyogenes M1 GAS]
- gi|71802795|gb|AAX72148.1| hypothetical protein M28_Spy1035 [Streptococcus pyogenes MGAS6180]
- gi|71853649|gb|AAZ51672.1| hypothetical protein M5005_Spy1054 [Streptococcus pyogenes phage 5005.1]
- gi|94542238|gb|ABF32287.1| phage protein [Streptococcus pyogenes MGAS9429]
- gi|94544127|gb|ABF34175.1| phage protein [Streptococcus pyogenes MGAS10270]
- gi|94546061|gb|ABF36108.1| phage protein [Streptococcus pyogenes MGAS2096]
- gi|19746281|ref|NP_607417.1|_2:205 hypothetical protein spyM18_1310 [Streptococcus pyogenes MGAS8232]
- gi|19748469|gb|AAL97916.1| hypothetical protein [Streptococcus pyogenes MGAS8232]
- gi|50914374|ref|YP_060346.1|_2:205 unknown phage protein [Streptococcus pyogenes MGAS10394]
- gi|50903448|gb|AAT87163.1| unknown phage protein [Streptococcus pyogenes MGAS10394]
- gi|21910515|ref|NP_664783.1|_2:205 hypothetical protein SpyM3_0979 [Streptococcus pyogenes MGAS315]
- gi|28895787|ref|NP_802137.1| hypothetical protein SPs0875 [Streptococcus pyogenes SSI-1]
- gi|21904715|gb|AAM79586.1| conserved hypothetical protein [Streptococcus pyogenes MGAS315]
- gi|28811036|dbj|BAC63970.1| hypothetical protein [Streptococcus pyogenes SSI-1]
- gi|76800382|ref|ZP_00782023.1|_4:199 conserved hypothetical protein [Streptococcus agalactiae 18RS21]
- gi|76584418|gb|EAO61382.1| conserved hypothetical protein [Streptococcus agalactiae 18RS21]
- gi|24379624|ref|NP_721579.1|_1:206 hypothetical protein SMU.1196c [Streptococcus mutans UA159]
- gi|24377575|gb|AAN58885.1|AE014956_6 conserved hypothetical protein [Streptococcus mutans UA159]
- gi|168180788|ref|ZP_02615452.1|_7:197 conserved hypothetical protein [Clostridium botulinum NCTC 2916]
- gi|182668531|gb|EDT80510.1| conserved hypothetical protein [Clostridium botulinum NCTC 2916]
- gi|153941070|ref|YP_001391563.1|_7:197 hypothetical protein CLI_2313 [Clostridium botulinum F str. Langeland]
- gi|170754377|ref|YP_001781875.1| conserved hypothetical protein [Clostridium botulinum B1 str. Okra]
- gi|152936966|gb|ABS42464.1| conserved hypothetical protein [Clostridium botulinum F str. Langeland]
- gi|169119589|gb|ACA43425.1| conserved hypothetical protein [Clostridium botulinum B1 str. Okra]
- gi|168183887|ref|ZP_02618551.1|_7:197 conserved hypothetical protein [Clostridium botulinum Bf]
- gi|182672946|gb|EDT84907.1| conserved hypothetical protein [Clostridium botulinum Bf]
- gi|148380213|ref|YP_001254754.1|_7:197 membrane protein [Clostridium botulinum A str. ATCC 3502]
- gi|153931015|ref|YP_001384517.1| hypothetical protein CLB_2204 [Clostridium botulinum A str. ATCC 19397]
- gi|153935786|ref|YP_001388033.1| hypothetical protein CLC_2187 [Clostridium botulinum A str. Hall]
- gi|148289697|emb|CAL83802.1| putative membrane protein [Clostridium botulinum A str. ATCC 3502]
- gi|152927059|gb|ABS32559.1| conserved hypothetical protein [Clostridium botulinum A str. ATCC 19397]
- gi|152931700|gb|ABS37199.1| conserved hypothetical protein [Clostridium botulinum A str. Hall]
- gi|170759226|ref|YP_001787641.1|_7:197 conserved hypothetical protein [Clostridium botulinum A3 str. Loch Maree]
- gi|169406215|gb|ACA54626.1| conserved hypothetical protein [Clostridium botulinum A3 str. Loch Maree]
- gi|148380245|ref|YP_001254786.1|_7:197 membrane protein [Clostridium botulinum A str. ATCC 3502]
- gi|153934157|ref|YP_001384550.1| hypothetical protein CLB_2239 [Clostridium botulinum A str. ATCC 19397]
- gi|153934734|ref|YP_001388066.1| hypothetical protein CLC_2222 [Clostridium botulinum A str. Hall]
- gi|148289729|emb|CAL83834.1| putative membrane protein [Clostridium botulinum A str. ATCC 3502]
- gi|152930201|gb|ABS35701.1| conserved hypothetical protein [Clostridium botulinum A str. ATCC 19397]
- gi|152930648|gb|ABS36147.1| conserved hypothetical protein [Clostridium botulinum A str. Hall]
- gi|168183929|ref|ZP_02618593.1|_7:197 conserved hypothetical protein [Clostridium botulinum Bf]
- gi|182672990|gb|EDT84951.1| conserved hypothetical protein [Clostridium botulinum Bf]
- gi|116629235|ref|YP_814407.1|_1:206 hypothetical protein LGAS_0573 [Lactobacillus gasseri ATCC 33323]
- gi|116629295|ref|YP_814467.1| hypothetical protein LGAS_0635 [Lactobacillus gasseri ATCC 33323]
- gi|116094817|gb|ABJ59969.1| hypothetical protein LGAS_0573 [Lactobacillus gasseri ATCC 33323]
- gi|116094877|gb|ABJ60029.1| hypothetical protein LGAS_0635 [Lactobacillus gasseri ATCC 33323]
- gi|90592577|ref|YP_529837.1|_1:206 hypothetical protein LGPKV5a_gp02 [Lactobacillus phage KC5a]
- gi|89891906|gb|ABD78779.1| hypothetical protein [Lactobacillus gasseri phage KC5a]
- gi|163932154|ref|YP_001642344.1|_1:206 hypothetical protein LJ771_002 [Lactobacillus johnsonii prophage Lj771]
- gi|163562108|gb|ABY26964.1| hypothetical protein LJ771_002 [Lactobacillus johnsonii prophage Lj771]
- gi|77409729|ref|ZP_00786389.1|_3:154 lipoprotein, putative [Streptococcus agalactiae COH1]
- gi|77171657|gb|EAO74866.1| lipoprotein, putative [Streptococcus agalactiae COH1]
- gi|77412739|ref|ZP_00788973.1|_1:165 lipoprotein, putative [Streptococcus agalactiae CJB111]
- gi|77161209|gb|EAO72286.1| lipoprotein, putative [Streptococcus agalactiae CJB111]
- gi|15895876|ref|NP_349225.1|_1:193 Hypothetical protein, CF-17 family [Clostridium acetobutylicum ATCC 824]
- gi|15025643|gb|AAK80565.1|AE007759_3 Hypothetical protein, CF-17 family [Clostridium acetobutylicum ATCC 824]
- gi|116513968|ref|YP_812874.1|_5:204 hypothetical protein LBUL_0831 [Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365]
- gi|116093283|gb|ABJ58436.1| hypothetical protein LBUL_0831 [Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365]
- gi|104773961|ref|YP_618941.1|_5:204 hypothetical protein Ldb0913 [Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842]
- gi|103423042|emb|CAI97733.1| Conserved hypothetical protein [Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842]
- gi|29376973|ref|NP_816127.1|_59:246 hypothetical protein EF2480 [Enterococcus faecalis V583]
- gi|29344438|gb|AAO82197.1| conserved hypothetical protein [Enterococcus faecalis V583]
- gi|3341433|emb|CAA76857.1|_59:246 hypothetical protein [Enterococcus faecalis]
- gi|168180750|ref|ZP_02615414.1|_2:90 putative membrane protein [Clostridium botulinum NCTC 2916]
- gi|182668464|gb|EDT80443.1| putative membrane protein [Clostridium botulinum NCTC 2916]
- gi|77412604|ref|ZP_00788889.1|_1:95 lipoprotein, putative [Streptococcus agalactiae CJB111]
- gi|77161344|gb|EAO72370.1| lipoprotein, putative [Streptococcus agalactiae CJB111]
- gi|116627483|ref|YP_820102.1|_2:70 hypothetical protein STER_0643 [Streptococcus thermophilus LMD-9]
- gi|116100760|gb|ABJ65906.1| Uncharacterized conserved protein [Streptococcus thermophilus LMD-9]
- gi|30261065|ref|NP_843442.1|_7:121 lipoprotein, putative [Bacillus anthracis str. Ames]
- gi|47526221|ref|YP_017571.1| lipoprotein, putative [Bacillus anthracis str. 'Ames Ancestor']
- gi|49183906|ref|YP_027158.1| lipoprotein, putative [Bacillus anthracis str. Sterne]
- gi|165871673|ref|ZP_02216318.1| putative lipoprotein [Bacillus anthracis str. A0488]
- gi|167635450|ref|ZP_02393763.1| putative lipoprotein [Bacillus anthracis str. A0442]
- gi|167638978|ref|ZP_02397252.1| putative lipoprotein [Bacillus anthracis str. A0193]
- gi|168172973|ref|ZP_02608202.1| lipoprotein, putative [Bacillus anthracis Tsiankovskii-I]
- gi|170687557|ref|ZP_02878773.1| putative lipoprotein [Bacillus anthracis str. A0465]
- gi|170707981|ref|ZP_02898430.1| putative lipoprotein [Bacillus anthracis str. A0389]
- gi|177653558|ref|ZP_02935732.1| putative lipoprotein [Bacillus anthracis str. A0174]
- gi|30254679|gb|AAP24928.1| lipoprotein, putative [Bacillus anthracis str. Ames]
- gi|47501369|gb|AAT30045.1| lipoprotein, putative [Bacillus anthracis str. 'Ames Ancestor']
- gi|49177833|gb|AAT53209.1| lipoprotein, putative [Bacillus anthracis str. Sterne]
- gi|164712574|gb|EDR18106.1| putative lipoprotein [Bacillus anthracis str. A0488]
- gi|167513108|gb|EDR88480.1| putative lipoprotein [Bacillus anthracis str. A0193]
- gi|167529068|gb|EDR91822.1| putative lipoprotein [Bacillus anthracis str. A0442]
- gi|170127141|gb|EDS96019.1| putative lipoprotein [Bacillus anthracis str. A0389]
- gi|170668370|gb|EDT19117.1| putative lipoprotein [Bacillus anthracis str. A0465]
- gi|172081362|gb|EDT66436.1| putative lipoprotein [Bacillus anthracis str. A0174]
- gi|65318347|ref|ZP_00391306.1|_8:121 COG0124: Histidyl-tRNA synthetase [Bacillus anthracis str. A2012]
- gi|55822564|ref|YP_141005.1|_4:72 hypothetical protein str0594 [Streptococcus thermophilus CNRZ1066]
- gi|55738549|gb|AAV62190.1| unknown protein [Streptococcus thermophilus CNRZ1066]
- gi|55820673|ref|YP_139115.1|_4:72 hypothetical protein stu0594 [Streptococcus thermophilus LMG 18311]
- gi|55736658|gb|AAV60300.1| unknown protein [Streptococcus thermophilus LMG 18311]
- gi|169185903|ref|ZP_02846065.1|_59:132 hypothetical protein Pjdr2DRAFT_1172 [Paenibacillus sp. JDR-2]
- gi|169007324|gb|EDS54173.1| hypothetical protein Pjdr2DRAFT_1172 [Paenibacillus sp. JDR-2]
- gi|153879384|ref|ZP_02004811.1|_13:86 conserved hypothetical protein [Beggiatoa sp. PS]
- gi|152064152|gb|EDN65189.1| conserved hypothetical protein [Beggiatoa sp. PS]
- gi|158335308|ref|YP_001516480.1|_51:113 hypothetical protein AM1_2152 [Acaryochloris marina MBIC11017]
- gi|158305549|gb|ABW27166.1| conserved hypothetical protein [Acaryochloris marina MBIC11017]
- gi|125718961|ref|YP_001036094.1|_239:384 hypothetical protein SSA_2178 [Streptococcus sanguinis SK36]
- gi|125498878|gb|ABN45544.1| Uncharacterized protein [Streptococcus sanguinis SK36]
- gi|148262331|ref|YP_001229037.1|_23:78 hypothetical protein Gura_0248 [Geobacter uraniumreducens Rf4]
- gi|146395831|gb|ABQ24464.1| hypothetical protein Gura_0248 [Geobacter uraniireducens Rf4]
- gi|110602381|ref|ZP_01390485.1|_22:76 conserved hypothetical protein of beta-lactamase-inhibitor family (Pfam) [Geobacter sp. FRC-32]
- gi|110546907|gb|EAT60229.1| conserved hypothetical protein of beta-lactamase-inhibitor family (Pfam) [Geobacter sp. FRC-32]
- gi|118579387|ref|YP_900637.1|_22:78 hypothetical protein Ppro_0950 [Pelobacter propionicus DSM 2379]
- gi|118502097|gb|ABK98579.1| conserved hypothetical protein [Pelobacter propionicus DSM 2379]
- gi|53802384|ref|YP_112844.1|_25:61 lipoprotein, putative [Methylococcus capsulatus str. Bath]
- gi|53756145|gb|AAU90436.1| putative lipoprotein [Methylococcus capsulatus str. Bath]
- gi|119898520|ref|YP_933733.1|_22:74 conserved hypothetical secreted protein [Azoarcus sp. BH72]
- gi|119670933|emb|CAL94846.1| conserved hypothetical secreted protein [Azoarcus sp. BH72]
- gi|56478050|ref|YP_159639.1|_22:78 hypothetical protein of beta-lactamase-inhibitor family (Pfam) [Azoarcus sp. EbN1]
- gi|56314093|emb|CAI08738.1| hypothetical protein of beta-lactamase-inhibitor family (Pfam) [Azoarcus sp. EbN1]

              10        20        30          40          50        60 
              |         |         |           |           |         | 
   1 MSMKKTKNWLLVFLTVTFCFLMLGCQSKEDKKGGTKPSN..EAALTKTEN..LDFRLSFNKIKVT
   2 MIPLKKITVGTIICLSFLGLTACSSSNTQQTSTSKSNVS..QHKNIKADH..EELRLKFNKVKLG
   3 MIPLKKITVGTIVCLSFLGLTACSSSNTQQTSTSKSNVS..QHKNIKADH..EELRLKFNKVKLG
   4 ----TKKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEiiTPRLHQAAH..QDKRANFEKIKLA
   5 ----TKKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEniTPRLHQAAH..QDKRANFEKIKLA
   6 ----TKKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEiiTPRLHQAAH..QDKRANFEKIKLA
   7 ----TKKHLLTLLLISFFTSFLVACSTTKDKKPQPSDSEiiTPRLHQAAH..QDKRANFEKIKLA
   8 ----TKKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEiiTPRLHQAAH..QDKRANFEKIKLA
   9 ----TKKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEiiTPRLHQAAH..QDKRANFEKIKLA
  10 ----------TIVCLSFLGLTACSSSNTQQTXTSKSNVS..QHKNIKADH..EELRLKFNKVKLG
  11 MSMKKTKNWLLVFLTVTFCFLMLGCQSKEDKKGGTKPSN..EAALTKTEN..LDFRLSFNKIKVT
  12 -EPFYKKIWFWIIAIVIICGVASYGDSKKINITDTKNSD..KTEIKKDDT..RKVTY--------
  13 -EPFYKKIWFWIIAIVIVCGVASYGDSKKINITDTKNSA..KTETKKDDT..RKVTY--------
  14 -EPFYKKIWFWIIAIVIVFGVASYGGSKKINITDTKNSP..KTEIKKDDT..RKVTY--------
  15 -EPFYKKIWFWIIAIVIVCGVASYGDSKKINITDTKNSA..KTDTKKDDT..RKVTY--------
  16 -EPFYKKIWFWIIAMVIVFGVANYGGSKKINIIDTKNSS..ETGIKKDDT..RKVTY--------
  17 -KPFYKKFWIWIIAIIIIGGVIGSNGSKKTGNTSNNSST..KKEAKKEDT..RKITY--------
  18 -KPFYKKFWFWIIAIIIIGGVIGSNGSKKTGNTSNNNST..KKEAKKEDT..RKITY--------
  19 MKKKYLVAATGLALLGLSMSACSSNSGSKSDSAKTSQKK..KKNETISQN..KELREKFDQIKVG
  20 MKKKYLVAATGLALLGLSMSACSSNSGSKSDSATTSQQK..KKNETISQN..KELREKFDQVKVG
  21 MKKKYLVAATGLALLGLSLSACSSNSSKGNSEKTTEQSK..KKNKVISQN..KELREKFDQIKVG
  22 ---------------------------------------..---------..------FNKVKLG
  23 MIPLKKITVGTIVCLSFLGLTACSSSNTQQTSTSKSNVS..QHKNIKADH..EELRLKFNKVKLG
  24 MKSKMKIIFSITMFFALVSVGVIKLNKENAAAYAAKGKA..LSHHMKNSV..KDKKYSMKK----
  25 -----------VLLIAFAALALTACSSKKATTDSESDKK..AASSISSSNvvKQTSNKINLTNYK
  26 -----------VLLIAFAALALTACSSKKATTDSESDKK..AASSISSSNvvKQNSNKINLTNYK
  27 -----------------------ATNSSKNDTKKESSEK..KSEDKSKDN..SDLKATYDKINVG
  28 -----------------------ATNSSKNDTKKESSEK..KSEDKSKDN..SDLKATYDKINVG
  29 ---------------------------------------..---------..-------------
  30 MIPLKKITVGTIVCLSFLGLTACSSSNTQQTSTSKSNVS..QHKNIKADH..EELRLKFNKVKLG
  31 ---------------------------------------..---------..-------------
  32 ----------ILVLGSAVALSLVACGDSTKEASNEKKEE..PKQEAKKEN..KENKESKKKITAA
  33 -----------LVLGSAVALSLVACGDSTKEASNEKKEX..PKQEAKKEN..KENKESKKKITAA
  34 ---------------------------------------..---------..-------------
  35 ---------------------------------------..---------..-------------
  36 ---------------------------------------..---------..-------------
  37 ---------------------------------------..---------..-------------
  38 ---------------------------------------..---------..-------------
  39 ------------------------------SEKDLTSTN..RSELIAGED..YQFHITYDDIALL
  40 ---------------------------------------..---------..-------------
  41 ---------------------------------------..---------..-------------
  42 ---------------------------------------..---------..-------------
  43 ---------------------------------------..---------..-------------
  44 ---------------------------------------..---------..-------------
  45 --------------------------KVTV---------..---------..-------------


              70        80         90       100             110        
              |         |          |         |               |        
   1 TDQNHFSG.GTSIEQLKQWFG.DPNKSEQRNAGNITLDSYTW.VKDG.....AVINAQ.LYKNST
   2 VKANNFKG.GTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.NVDD.....ISITIQ.LLNDSS
   3 VKANNFKG.GTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.NVDD.....ISITIQ.LLNDSS
   4 TVDSSFTG.GTSLEELISLFG.EPNQHDPKTAGEVTIDAYTW.QFDQ.....VTLTVN.LYQNSS
   5 TVDSSFTG.GTSLEELISLFG.EPNQHDPKTAGEVTIDAYTW.QFDQ.....VTLTVN.LYQNSS
   6 TVDSSFTG.GTSLEELISLFG.EPSQHDPKTAGEVTIDAYTW.QFDQ.....VTLTVN.LYQNSS
   7 TVDSSFTG.GTSLEELISLFG.EPSQHDPKTAGEVTIDAYTW.QFDQ.....VTLTVN.LYQNSS
   8 TVDSSFTG.GTSLEELISLFG.EPSQHDPKTAGEVTINAYTW.QFDQ.....VTLTVN.LYQNSS
   9 TVDSSFTG.GTSLEELISLFG.EPSQHDPKTAGEVTIDAYTW.QFDQ.....VTLTVN.LYQNSS
  10 VKANNFKG.GTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.NVDD.....ISITIQ.LLNDSS
  11 TDQNHFSG.GTSIEQLKQWFG.DPNKSEQRNAGNITLDSYTW.VKDG.....AVINAQ.LYKNST
  12 EKFCKIKI.GSTYEEVKSILG.EYKESKESEINGMKVVIYSW.YNDDn....SNMEVI.VKNNKV
  13 EKFCKIKI.GSTYEEVKSILG.EYKESKESEINGMKVVIYSW.YNDDn....SNMEVI.VKNNKV
  14 EKFCKIKI.GSTYEEVKSILG.EYKESKESEIDGMKVVIYTW.YNDDn....SNMEVI.VKNNKV
  15 EKFCKIKI.GSTYEEVKSILG.EYKESKESEINDMKVVIYSW.YNDDn....SNMEVI.VKNNKV
  16 EKFCKIKI.GSTYEEVKSILG.EYKESKESEINGMKVVIYTW.YNDDn....SNMEVI.VKNNKV
  17 EKFSKVKM.GSTYEDVKNMLG.EAKESTSSEMGGIKTVIYTWdNGDG.....SNMNVT.FQNNKA
  18 EKFSKVKM.GSTYEDVKNMLG.EGKESTSSEMGGIKTVIYTWdNGDG.....SNMNVT.FQNNKA
  19 ELSNHGEG.GSTIQDVEKLLG.KANTTDTTTVDSYKTKSYIW.NKGA.....VTVTVQ.FEPDKA
  20 ELSKHGEG.GSTIQDVEKLLG.KANTTDTTTVESYKTKSYIW.NKGA.....VTVTVQ.FEPDKV
  21 NFLSQGEG.GSTIDEVKQLLG.SPTSTTTTSSNGVKLKQLTW.TKGA.....VTVAIQtLDSNKV
  22 VKANNFKG.GTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.NVDD.....ISITIQ.LLNDSS
  23 VKANNFKG.GTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.NVDD.....ISITIQ.LLNDSS
  24 --FLRINM.GMNYKSVENILG.VSEKTGQINDKRELMNHQWK.NSDD.....SYIVVI.TKNNYV
  25 KIKVVEKT.GSTPSQVTDLLGrEADAKSKAKTSKLKATIYTW.EGVQngsagANLAVE.FANGVA
  26 KIKVVEKT.GSTPSQVTDLLGrEADAKSKAKTSKLKATIYTW.EGVQngsagANLAVE.FANGVA
  27 DIMNSSEG.GSTEDEVKAILG.EPASSSTTDIQGISTTTLSW.TNVKggdllASITVS.FSDGKA
  28 DIMNSSEG.GSTEDEVKAILG.EPASSSTTDIQGISTTTLSW.TNVKggdllASITVS.FSDGKA
  29 --------.GSTYEEVKNMLG.EGKESTSSEMGGIKTVIYTWdNGDG.....SNMNVT.FQNNKA
  30 VKANNFKG.GTSLAELTIIWW.RTNEX-LITAGNVTL-----.----.....------.------
  31 --------.------------.--------------------.----.....------.------
  32 DV-EAIKV.GDSLT-------.--------------------.----.....------.------
  33 DV-EAIKV.GDSLT-------.--------------------.----.....------.------
  34 --------.------------.--------------------.----.....------.------
  35 --------.------------.--------------------.----.....------.------
  36 --------.------------.--------------------.----.....------.------
  37 --------.------------.--------------------.----.....------.------
  38 --------.------------.--------------------.----.....------.------
  39 FADFKGTAsRLTADEVVAKLG.KAKSGREHNYDNQIITLNLD.YPDAgsn..ASVSIS.FSSYGS
  40 --------.------------.--------------------.----.....------.------
  41 --------.------------.--------------------.----.....------.------
  42 --------.------------.--------------------.----.....------.------
  43 --------.------------.--------------------.----.....------.------
  44 --------.------------.--------------------.----.....------.------
  45 ENYDKIRV.GMTYDEVKQLLG.APNRCSD----VMTVKSCTW.GDEK.....RHVQVS.FVADQV


        120            130       140         150        160       170  
         |              |         |           |          |         |  
   1 VA..RSISNFSFS.....REAKIGKEDYDELKIGESY..KKVVEKLG.EPDVLSQSMSSDKEEMQ
   2 IV..RSISNFKFI.....RDANITTKDYNSLKNGMSY..NKVKELLG.EPDDISQAVSSDKEELQ
   3 IV..RSISNFKFI.....RDANITTKDYNSLKNGMSY..NKVKELLG.EPDDISQAVSSDKEELQ
   4 IV..KTISNFTFA.....RELGLSQKEYQQLQKGMSY..EDVKKILT.EPDNYSQASSSDHQTLQ
   5 IV..KTISNFTFA.....RELGLSQKEYQQLQKGMSY..EDVKKILT.EPDNYSQASSSDHQTLQ
   6 IV..KTISNFTFA.....RELGLSQKEYQQLQKGMSY..EDVKKILT.EPDNYSQASSSDHQTLQ
   7 IV..KTISNFTFA.....RELGLSQKEYQQLQKGMSY..EDVKKILT.EPDNYSQASSSDHQTLQ
   8 IV..KTISNFTFA.....RELGLSQKEYQQLQKGMSY..EDAKKILT.EPDNYSQASSSDHQTLQ
   9 IV..KTISNFTFA.....RELGLSQKEYQQLQKRMSY..EDVKKILT.EPDNYSQASSSDHQTLQ
  10 IV..RSISNFKFI.....RDANITTKDYNSLKNGMSY..NKVKELLG.EPDDISQAVSSDKEELQ
  11 VA..RSISNFSFS.....REAKIGKEDYDELKIGESY..KKVVEKLG.EPDVLSQSMSSDKEEMQ
  12 IG..KAQAGLSMG.....K-ADVNLIKYAKITTGMDY..SKVEEILG.DGKLMSISKTNGSTKSI
  13 IG..KAQAGLSMG.....K-ADVNLIKYAKITTGMDY..SKVEEILG.DGKLMSISKTNGSTKSI
  14 IG..KAQAGLSMG.....K-ADVNLIKYTKIRTGMDY..SKVKEILG.DGKLMSISKTNGSTKSI
  15 IG..KAQAGLSMG.....K-ADVNLIKYAKITTGMDY..SKVEEILG.DGKLMSISKTNGSTKSI
  16 IG..KAQADLSMG.....K-ADVNLIKYAKITTGMDY..SKVEEILG.DGKLMSISKTNGSTKSI
  17 LA..KAQAGLSRK.....R-ADVNMEKYNKIQTGMDY..NKVKEILG.DGELMSISEVGGSNTSI
  18 LA..KAQAGLSRE.....K-ADVNMEKYNTIQTGMDY..NKIKEILG.AGELMSISEVGGSNTSI
  19 VT..KDITGFKWGk....RDEKLDLAAFNSIQDGATY..DDIVKKYG.EPDSLNESLLLGTKTVT
  20 VT..KDITGFKWGk....RDEKLDLAAFNSIQDGASY..DDIVKKYG.EPDSLNESLLLGTKTVT
  21 VS..KEITGFKWGk....RDEKLTLGEFNNIADGSTY..QSLVDKYG.EPDGLHEANVAGTKITN
  22 IV..RSISNFKFI.....RDANITTKDYNSLKNGMSY..NKVKELLG.EPDDISQAVSSDKEELQ
  23 IV..RSISNFKFI.....RDANITTKDYNSLKNXXSY..NKVKELLG.EPDDISQAV--------
  24 VS..KIEIGLEKI.....N-ANISRVKYKKISRGMSY..EKVKNLVG.KGELLSETNLMGSNSKM
  25 IA..KQISGLVVN.....RSKQITPKDYKSLKKGMTQ..EEVEAIVG.KPNGYSESDYSNSEVVL
  26 IA..KQISGLVVN.....RSKQITPKDYKSLKKGMTQ..EEVEAIVG.KPNGYSESDYSNSEVVL
  27 AS..KSVSGLKVA.....KHDKVTADQVNNIATDGSYseEQARKDLG.DPTGITSTNINGEKNDT
  28 AS..KSVSGLKVA.....KHDKVTADQVNNIATDGSYseEQARKDLG.DPTGITSTNINGEKNDT
  29 LA..KAQAGLSRE.....R-ADVNAEKYNRIQTGMDY..NKVKEILG.DGE--------------
  30 --..---------.....-------------------..--------.-----------------
  31 --..---------.....---------YEDLKNGTSY..DNAVKILG.VPDVYSIAVSSDATMTQ
  32 --..----G----.....-------------AGGEKY..EDVVAKFG.EPDNKAESQAGDIKMII
  33 --..----G----.....-------------AGGEKY..EDVVAKFG.EPDNKAESQAGDIKMII
  34 --..---------.....---------YEDLKNGTSY..DNAVKTLG.VPDVYSIAVSSDATMTQ
  35 --..---------.....---------YEDLKNGTSY..DNAVQTLG.VPDVYSIAVSSDATMTQ
  36 --..---------.....----ITKENYDKVKNGMSY..EEVVKIIGsEGEIVTETGEKGDDMYG
  37 IA..IVLSAFLFG.....CFSKINQENYAKIENGMTM..EQVKDILG.EPTESQTAGIGSLSGTN
  38 --..---------.....--ELVSQEKYKQLKLDMSY..EDVKKIMG.SPGKVKKFPGQPSTETT
  39 VGtpKLDSLFSHHls8pnRNSQLTRQDFSGIEKGKSY..QEVVGQLG.LPDSLSI----------
  40 --..---------.....----LTMENYSKIKTGIGY..TEVVKILG.KPDNCSEALFV------
  41 --..---------.....----LTTENYEKIKMGMDY..GEVAGILG.KPDSCSEALFAKS----
  42 --..---------.....---KLTQENYAKLKMGLGY..GEVVTILG.KPDSCSEALFAKSC---
  43 --..---------.....-ENKVTRENYDKLAIGMEY..SKVVELLG.EPENCQSVVSV------
  44 --..---------.....-------ENYDKLRMGMHY..AEVKSILG.EPTRCSDLLAV----KA
  45 V-..---------.....-------------------..--------.-----------------


           180        190       200      
            |          |         |      
   1 TVWSSGIKTKSSSA.TIELYFENGLLKNKTQKDLE
   2 AAWISGIQSSDSDP.GINLTFENDKLTNKQQHGL-
   3 AAWISGIQSSDSDP.GINLTFENDKLTNKQQHGL-
   4 AIWVSGLKTDTSGA.NISLVFENNQLTEMSQVGLE
   5 AIWVSGLKTDTSGA.NISLVFENNQLTEMSQVGLE
   6 AIWVSGLKTDTSGA.NISLVFENNQLTEMSQVGLE
   7 AIWVSGLKTDTSGA.NISLVFENNQLTEMSQVGLE
   8 AIWVSGLKTDTSGA.NISLVFENNQLTEMSQVGLE
   9 AIWVSGLKTDTSGA.NISLVFENNQLTEMSQVGLE
  10 AAWISGIQSSDSDP.GINLTFENDKLTNKQQHGL-
  11 TVWSSGIKTKSSSA.TIELYFENGLLKNKTQKDLE
  12 YLWA-----NPNGT.NMNVTFQNGKVTAKNRLGL-
  13 YLWA-----NPNGT.NMNVTFQNGKVTAKNRLGL-
  14 YLWA-----NPNGT.NMNVTFQNGKVTTKNRLGL-
  15 YLWA-----NPNGT.NMNVTFQNGKVTAKNRLGL-
  16 YLWA-----NPNGT.NMNVTFQNGKVTAKNRLGL-
  17 YSWV-----NSNGT.NINVTFQDGKSAAKAQFGL-
  18 YSWV-----NSNGT.NMNVTFQDGKSAAKAQFGL-
  19 GLWYTGIKGKADGA.FASLTFENGALTSKTQTDL-
  20 ALWYTGIKGKGAGA.NASLTFENGALTSKTQTDL-
  21 AVWLTGIK-GDDGA.SATFSFENDKLSSKTQTKL-
  22 AAWISGIQSSDSDP.GINLTFENDKLTNKQQHGL-
  23 --------------.--------------------
  24 YQWV-----NSDGS.SMNITFTNGIVDYKTEKKL-
  25 WLYTSGLK-SDDQA.NFYVTFQKNKLVAKKAQN--
  26 WLYTSGLK-SDDQA.NFYVTFQKNKLVAKKAQN--
  27 LIWMKNLD-GDLGA.TVTVSFSNGSAISKSSSGL-
  28 LIWMKNLD-GDLGA.TVTVSFSNGNAISKSSSGL-
  29 --------------.--------------------
  30 --------------.--------------------
  31 ALWSSNLVTKKGKTgSLTLNFKNGTLENKSQENL-
  32 ASWTKNVN-GDLGA.NFNVTFT-------------
  33 ASWTKNVN-GDLGA.NFNVTFT-------------
  34 ALWSSNLVTKKGKTgSLTLNFKNGTLENKSQENL-
  35 ALWSSNLVTKKGKTgSLTLNFKNGTLENKSQENL-
  36 IAVLYENK-GSSLS.NATFIFLGDKLQSKSQYGLE
  37 AIW------KSDSV.TIKLTFVNSKV---------
  38 YVWK----QKNSSY.RILVTLKDGKV---------
  39 --------------.--------------------
  40 ----RNCVWGNEQK.NITVSFVGDKAI--------
  41 CIW------GNEQK.NITVNFVGDKT---------
  42 -VW------GDEQK.NITVNFAGDRVV--------
  43 --------------.--------------------
  44 CTW------GDDAR.YINVNFVADQAV--------
  45 --------------.--------------------