a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0399
- gi|139473649|ref|YP_001128365.1|_3:205 putative lipoprotein [Streptococcus pyogenes str. Manfredo]
- gi|134271896|emb|CAM30134.1| putative lipoprotein [Streptococcus pyogenes str. Manfredo]
- gi|76787941|ref|YP_329852.1|_1:207 hypothetical protein SAK_1235 [Streptococcus agalactiae A909]
- gi|77414874|ref|ZP_00790984.1| putative lipoprotein [Streptococcus agalactiae 515]
- gi|76562998|gb|ABA45582.1| conserved hypothetical protein [Streptococcus agalactiae A909]
- gi|77159075|gb|EAO70276.1| putative lipoprotein [Streptococcus agalactiae 515]
- gi|22537307|ref|NP_688158.1|_1:207 lipoprotein, putative [Streptococcus agalactiae 2603V/R]
- gi|25011265|ref|NP_735660.1| hypothetical protein gbs1216 [Streptococcus agalactiae NEM316]
- gi|76798884|ref|ZP_00781091.1| lipoprotein, putative [Streptococcus agalactiae 18RS21]
- gi|77406670|ref|ZP_00783712.1| lipoprotein, putative [Streptococcus agalactiae H36B]
- gi|22534177|gb|AAN00031.1|AE014244_8 lipoprotein, putative [Streptococcus agalactiae 2603V/R]
- gi|23095689|emb|CAD46875.1| unknown [Streptococcus agalactiae NEM316]
- gi|76585753|gb|EAO62304.1| lipoprotein, putative [Streptococcus agalactiae 18RS21]
- gi|77174711|gb|EAO77538.1| lipoprotein, putative [Streptococcus agalactiae H36B]
- gi|94994542|ref|YP_602640.1|_3:205 phage protein [Streptococcus pyogenes MGAS10750]
- gi|94548050|gb|ABF38096.1| phage protein [Streptococcus pyogenes MGAS10750]
- gi|15675243|ref|NP_269417.1|_3:205 hypothetical protein SPy_1290 [Streptococcus pyogenes M1 GAS]
- gi|56808027|ref|ZP_00365829.1| COG2352: Phosphoenolpyruvate carboxylase [Streptococcus pyogenes M49 591]
- gi|71903700|ref|YP_280503.1| hypothetical protein M28_Spy1035 [Streptococcus pyogenes MGAS6180]
- gi|71910867|ref|YP_282417.1| hypothetical protein M5005_Spy_1054 [Streptococcus pyogenes phage 5005.1]
- gi|94988730|ref|YP_596831.1| phage protein [Streptococcus pyogenes MGAS9429]
- gi|94990619|ref|YP_598719.1| phage protein [Streptococcus pyogenes MGAS10270]
- gi|94992553|ref|YP_600652.1| phage protein [Streptococcus pyogenes MGAS2096]
- gi|13622414|gb|AAK34138.1| hypothetical protein SPy_1290 [Streptococcus pyogenes M1 GAS]
- gi|71802795|gb|AAX72148.1| hypothetical protein M28_Spy1035 [Streptococcus pyogenes MGAS6180]
- gi|71853649|gb|AAZ51672.1| hypothetical protein M5005_Spy1054 [Streptococcus pyogenes phage 5005.1]
- gi|94542238|gb|ABF32287.1| phage protein [Streptococcus pyogenes MGAS9429]
- gi|94544127|gb|ABF34175.1| phage protein [Streptococcus pyogenes MGAS10270]
- gi|94546061|gb|ABF36108.1| phage protein [Streptococcus pyogenes MGAS2096]
- gi|19746281|ref|NP_607417.1|_3:205 hypothetical protein spyM18_1310 [Streptococcus pyogenes MGAS8232]
- gi|19748469|gb|AAL97916.1| hypothetical protein [Streptococcus pyogenes MGAS8232]
- gi|50914374|ref|YP_060346.1|_3:205 unknown phage protein [Streptococcus pyogenes MGAS10394]
- gi|50903448|gb|AAT87163.1| unknown phage protein [Streptococcus pyogenes MGAS10394]
- gi|21910515|ref|NP_664783.1|_3:205 hypothetical protein SpyM3_0979 [Streptococcus pyogenes MGAS315]
- gi|28895787|ref|NP_802137.1| hypothetical protein SPs0875 [Streptococcus pyogenes SSI-1]
- gi|21904715|gb|AAM79586.1| conserved hypothetical protein [Streptococcus pyogenes MGAS315]
- gi|28811036|dbj|BAC63970.1| hypothetical protein [Streptococcus pyogenes SSI-1]
- gi|76800382|ref|ZP_00782023.1|_5:200 conserved hypothetical protein [Streptococcus agalactiae 18RS21]
- gi|76584418|gb|EAO61382.1| conserved hypothetical protein [Streptococcus agalactiae 18RS21]
- gi|24379624|ref|NP_721579.1|_1:206 hypothetical protein SMU.1196c [Streptococcus mutans UA159]
- gi|24377575|gb|AAN58885.1|AE014956_6 conserved hypothetical protein [Streptococcus mutans UA159]
- gi|153941070|ref|YP_001391563.1|_1:197 hypothetical protein CLI_2313 [Clostridium botulinum F str. Langeland]
- gi|170754377|ref|YP_001781875.1| conserved hypothetical protein [Clostridium botulinum B1 str. Okra]
- gi|152936966|gb|ABS42464.1| conserved hypothetical protein [Clostridium botulinum F str. Langeland]
- gi|169119589|gb|ACA43425.1| conserved hypothetical protein [Clostridium botulinum B1 str. Okra]
- gi|168180788|ref|ZP_02615452.1|_1:197 conserved hypothetical protein [Clostridium botulinum NCTC 2916]
- gi|182668531|gb|EDT80510.1| conserved hypothetical protein [Clostridium botulinum NCTC 2916]
- gi|148380213|ref|YP_001254754.1|_1:197 membrane protein [Clostridium botulinum A str. ATCC 3502]
- gi|153931015|ref|YP_001384517.1| hypothetical protein CLB_2204 [Clostridium botulinum A str. ATCC 19397]
- gi|153935786|ref|YP_001388033.1| hypothetical protein CLC_2187 [Clostridium botulinum A str. Hall]
- gi|148289697|emb|CAL83802.1| putative membrane protein [Clostridium botulinum A str. ATCC 3502]
- gi|152927059|gb|ABS32559.1| conserved hypothetical protein [Clostridium botulinum A str. ATCC 19397]
- gi|152931700|gb|ABS37199.1| conserved hypothetical protein [Clostridium botulinum A str. Hall]
- gi|168183887|ref|ZP_02618551.1|_1:197 conserved hypothetical protein [Clostridium botulinum Bf]
- gi|182672946|gb|EDT84907.1| conserved hypothetical protein [Clostridium botulinum Bf]
- gi|170759226|ref|YP_001787641.1|_1:197 conserved hypothetical protein [Clostridium botulinum A3 str. Loch Maree]
- gi|169406215|gb|ACA54626.1| conserved hypothetical protein [Clostridium botulinum A3 str. Loch Maree]
- gi|148380245|ref|YP_001254786.1|_1:198 membrane protein [Clostridium botulinum A str. ATCC 3502]
- gi|153934157|ref|YP_001384550.1| hypothetical protein CLB_2239 [Clostridium botulinum A str. ATCC 19397]
- gi|153934734|ref|YP_001388066.1| hypothetical protein CLC_2222 [Clostridium botulinum A str. Hall]
- gi|148289729|emb|CAL83834.1| putative membrane protein [Clostridium botulinum A str. ATCC 3502]
- gi|152930201|gb|ABS35701.1| conserved hypothetical protein [Clostridium botulinum A str. ATCC 19397]
- gi|152930648|gb|ABS36147.1| conserved hypothetical protein [Clostridium botulinum A str. Hall]
- gi|168183929|ref|ZP_02618593.1|_1:198 conserved hypothetical protein [Clostridium botulinum Bf]
- gi|182672990|gb|EDT84951.1| conserved hypothetical protein [Clostridium botulinum Bf]
- gi|90592577|ref|YP_529837.1|_1:207 hypothetical protein LGPKV5a_gp02 [Lactobacillus phage KC5a]
- gi|89891906|gb|ABD78779.1| hypothetical protein [Lactobacillus gasseri phage KC5a]
- gi|116629235|ref|YP_814407.1|_1:207 hypothetical protein LGAS_0573 [Lactobacillus gasseri ATCC 33323]
- gi|116629295|ref|YP_814467.1| hypothetical protein LGAS_0635 [Lactobacillus gasseri ATCC 33323]
- gi|116094817|gb|ABJ59969.1| hypothetical protein LGAS_0573 [Lactobacillus gasseri ATCC 33323]
- gi|116094877|gb|ABJ60029.1| hypothetical protein LGAS_0635 [Lactobacillus gasseri ATCC 33323]
- gi|77409729|ref|ZP_00786389.1|_3:155 lipoprotein, putative [Streptococcus agalactiae COH1]
- gi|77171657|gb|EAO74866.1| lipoprotein, putative [Streptococcus agalactiae COH1]
- gi|163932154|ref|YP_001642344.1|_1:207 hypothetical protein LJ771_002 [Lactobacillus johnsonii prophage Lj771]
- gi|163562108|gb|ABY26964.1| hypothetical protein LJ771_002 [Lactobacillus johnsonii prophage Lj771]
- gi|77412739|ref|ZP_00788973.1|_1:164 lipoprotein, putative [Streptococcus agalactiae CJB111]
- gi|77161209|gb|EAO72286.1| lipoprotein, putative [Streptococcus agalactiae CJB111]
- gi|15895876|ref|NP_349225.1|_1:194 Hypothetical protein, CF-17 family [Clostridium acetobutylicum ATCC 824]
- gi|15025643|gb|AAK80565.1|AE007759_3 Hypothetical protein, CF-17 family [Clostridium acetobutylicum ATCC 824]
- gi|116513968|ref|YP_812874.1|_5:204 hypothetical protein LBUL_0831 [Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365]
- gi|116093283|gb|ABJ58436.1| hypothetical protein LBUL_0831 [Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365]
- gi|104773961|ref|YP_618941.1|_5:204 hypothetical protein Ldb0913 [Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842]
- gi|103423042|emb|CAI97733.1| Conserved hypothetical protein [Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842]
- gi|29376973|ref|NP_816127.1|_61:247 hypothetical protein EF2480 [Enterococcus faecalis V583]
- gi|29344438|gb|AAO82197.1| conserved hypothetical protein [Enterococcus faecalis V583]
- gi|3341433|emb|CAA76857.1|_61:247 hypothetical protein [Enterococcus faecalis]
- gi|118442880|ref|YP_878434.1|_7:177 hypothetical protein NT01CX_2361 [Clostridium novyi NT]
- gi|118133336|gb|ABK60380.1| conserved hypothetical protein [Clostridium novyi NT]
- gi|168186573|ref|ZP_02621208.1|_6:175 conserved hypothetical protein [Clostridium botulinum C str. Eklund]
- gi|169295492|gb|EDS77625.1| conserved hypothetical protein [Clostridium botulinum C str. Eklund]
- gi|168180750|ref|ZP_02615414.1|_2:90 putative membrane protein [Clostridium botulinum NCTC 2916]
- gi|182668464|gb|EDT80443.1| putative membrane protein [Clostridium botulinum NCTC 2916]
- gi|169185903|ref|ZP_02846065.1|_44:132 hypothetical protein Pjdr2DRAFT_1172 [Paenibacillus sp. JDR-2]
- gi|169007324|gb|EDS54173.1| hypothetical protein Pjdr2DRAFT_1172 [Paenibacillus sp. JDR-2]
- gi|119898520|ref|YP_933733.1|_11:82 conserved hypothetical secreted protein [Azoarcus sp. BH72]
- gi|119670933|emb|CAL94846.1| conserved hypothetical secreted protein [Azoarcus sp. BH72]
- gi|148262331|ref|YP_001229037.1|_20:86 hypothetical protein Gura_0248 [Geobacter uraniumreducens Rf4]
- gi|146395831|gb|ABQ24464.1| hypothetical protein Gura_0248 [Geobacter uraniireducens Rf4]
- gi|110602381|ref|ZP_01390485.1|_18:85 conserved hypothetical protein of beta-lactamase-inhibitor family (Pfam) [Geobacter sp. FRC-32]
- gi|110546907|gb|EAT60229.1| conserved hypothetical protein of beta-lactamase-inhibitor family (Pfam) [Geobacter sp. FRC-32]
- gi|118579387|ref|YP_900637.1|_19:86 hypothetical protein Ppro_0950 [Pelobacter propionicus DSM 2379]
- gi|118502097|gb|ABK98579.1| conserved hypothetical protein [Pelobacter propionicus DSM 2379]
- gi|153879384|ref|ZP_02004811.1|_7:89 conserved hypothetical protein [Beggiatoa sp. PS]
- gi|152064152|gb|EDN65189.1| conserved hypothetical protein [Beggiatoa sp. PS]
- gi|56478050|ref|YP_159639.1|_21:86 hypothetical protein of beta-lactamase-inhibitor family (Pfam) [Azoarcus sp. EbN1]
- gi|56314093|emb|CAI08738.1| hypothetical protein of beta-lactamase-inhibitor family (Pfam) [Azoarcus sp. EbN1]
- gi|77412604|ref|ZP_00788889.1|_1:87 lipoprotein, putative [Streptococcus agalactiae CJB111]
- gi|77161344|gb|EAO72370.1| lipoprotein, putative [Streptococcus agalactiae CJB111]
- gi|116627483|ref|YP_820102.1|_2:70 hypothetical protein STER_0643 [Streptococcus thermophilus LMD-9]
- gi|116100760|gb|ABJ65906.1| Uncharacterized conserved protein [Streptococcus thermophilus LMD-9]
- gi|55822564|ref|YP_141005.1|_4:72 hypothetical protein str0594 [Streptococcus thermophilus CNRZ1066]
- gi|55738549|gb|AAV62190.1| unknown protein [Streptococcus thermophilus CNRZ1066]
- gi|55820673|ref|YP_139115.1|_4:72 hypothetical protein stu0594 [Streptococcus thermophilus LMG 18311]
- gi|55736658|gb|AAV60300.1| unknown protein [Streptococcus thermophilus LMG 18311]
- gi|53802384|ref|YP_112844.1|_23:89 lipoprotein, putative [Methylococcus capsulatus str. Bath]
- gi|53756145|gb|AAU90436.1| putative lipoprotein [Methylococcus capsulatus str. Bath]
- gi|158335308|ref|YP_001516480.1|_51:113 hypothetical protein AM1_2152 [Acaryochloris marina MBIC11017]
- gi|158305549|gb|ABW27166.1| conserved hypothetical protein [Acaryochloris marina MBIC11017]
- gi|47568759|ref|ZP_00239454.1|_91:157 conserved hypothetical protein protein [Bacillus cereus G9241]
- gi|47554539|gb|EAL12895.1| conserved hypothetical protein protein [Bacillus cereus G9241]
- gi|65318347|ref|ZP_00391306.1|_12:121 COG0124: Histidyl-tRNA synthetase [Bacillus anthracis str. A2012]
- gi|30261065|ref|NP_843442.1|_10:121 lipoprotein, putative [Bacillus anthracis str. Ames]
- gi|47526221|ref|YP_017571.1| lipoprotein, putative [Bacillus anthracis str. 'Ames Ancestor']
- gi|49183906|ref|YP_027158.1| lipoprotein, putative [Bacillus anthracis str. Sterne]
- gi|165871673|ref|ZP_02216318.1| putative lipoprotein [Bacillus anthracis str. A0488]
- gi|167635450|ref|ZP_02393763.1| putative lipoprotein [Bacillus anthracis str. A0442]
- gi|167638978|ref|ZP_02397252.1| putative lipoprotein [Bacillus anthracis str. A0193]
- gi|168172973|ref|ZP_02608202.1| lipoprotein, putative [Bacillus anthracis Tsiankovskii-I]
- gi|170687557|ref|ZP_02878773.1| putative lipoprotein [Bacillus anthracis str. A0465]
- gi|170707981|ref|ZP_02898430.1| putative lipoprotein [Bacillus anthracis str. A0389]
- gi|177653558|ref|ZP_02935732.1| putative lipoprotein [Bacillus anthracis str. A0174]
- gi|30254679|gb|AAP24928.1| lipoprotein, putative [Bacillus anthracis str. Ames]
- gi|47501369|gb|AAT30045.1| lipoprotein, putative [Bacillus anthracis str. 'Ames Ancestor']
- gi|49177833|gb|AAT53209.1| lipoprotein, putative [Bacillus anthracis str. Sterne]
- gi|164712574|gb|EDR18106.1| putative lipoprotein [Bacillus anthracis str. A0488]
- gi|167513108|gb|EDR88480.1| putative lipoprotein [Bacillus anthracis str. A0193]
- gi|167529068|gb|EDR91822.1| putative lipoprotein [Bacillus anthracis str. A0442]
- gi|170127141|gb|EDS96019.1| putative lipoprotein [Bacillus anthracis str. A0389]
- gi|170668370|gb|EDT19117.1| putative lipoprotein [Bacillus anthracis str. A0465]
- gi|172081362|gb|EDT66436.1| putative lipoprotein [Bacillus anthracis str. A0174]
- gi|47568759|ref|ZP_00239454.1|_186:319 conserved hypothetical protein protein [Bacillus cereus G9241]
- gi|47554539|gb|EAL12895.1| conserved hypothetical protein protein [Bacillus cereus G9241]
- gi|168135486|ref|ZP_02578715.1|_57:127 lipoprotein, putative [Bacillus cereus B4264]

              10        20        30        40          50        60   
              |         |         |         |           |         |   
   1 MSMKKTKNWLLVFLTVTFCFLMLGCQSKEDKKGGTKPSNEAALTKTEN..LDFRLSFNKIKVTTD
   2 ---KKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEIITPRLHQAAH..QDKRANFEKIKLATV
   3 MIPLKKITVGTIICLSFLGLTACSSSNTQQTSTSKSNVSQHKNIKADH..EELRLKFNKVKLGVK
   4 MIPLKKITVGTIVCLSFLGLTACSSSNTQQTSTSKSNVSQHKNIKADH..EELRLKFNKVKLGVK
   5 ---KKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSENITPRLHQAAH..QDKRANFEKIKLATV
   6 ---KKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEIITPRLHQAAH..QDKRANFEKIKLATV
   7 ---KKHLLTLLLISFFTSFLVACSTTKDKKPQPSDSEIITPRLHQAAH..QDKRANFEKIKLATV
   8 ---KKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEIITPRLHQAAH..QDKRANFEKIKLATV
   9 ---KKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEIITPRLHQAAH..QDKRANFEKIKLATV
  10 -----------IVCLSFLGLTACSSSNTQQTXTSKSNVSQHKNIKADH..EELRLKFNKVKLGVK
  11 MSMKKTKNWLLVFLTVTFCFLMLGCQSKEDKKGGTKPSNEAALTKTEN..LDFRLSFNKIKVTTD
  12 MLEKKEEPFYKKIWFWIIAIVIVCGVASYGDSKKINITDTKNSAKT--..-ETKKDDTRKVTYEK
  13 MLEKKEEPFYKKIWFWIIAIVIICGVASYGDSKKINITDTKNSDKT--..-EIKKDDTRKVTYEK
  14 MLEKKEEPFYKKIWFWIIAIVIVCGVASYGDSKKINITDTKNSAKT--..-DTKKDDTRKVTYEK
  15 MLEEKDEPFYKKIWFWIIAIVIVFGVASYGGSKKINITDTKNSPKT--..-EIKKDDTRKVTYEK
  16 MLEKKEEPFYKKIWFWIIAMVIVFGVANYGGSKKINIIDTKNSSET--..-GIKKDDTRKVTYEK
  17 MSKKAKKPFYKKFWIWIIAIIIIGGVIGSNGSKKTGNTSNNSSTKK--..-EAKKEDTRKITYEK
  18 MSKRVKKPFYKKFWFWIIAIIIIGGVIGSNGSKKTGNTSNNNSTKK--..-EAKKEDTRKITYEK
  19 MKKKYLVAATGLALLGLSMSACSSNSGSKSDSATTSQQKKKNETISQN..KELREKFDQVKVGEL
  20 MKKKYLVAATGLALLGLSMSACSSNSGSKSDSAKTSQKKKKNETISQN..KELREKFDQIKVGEL
  21 ------------------------------------------------..------FNKVKLGVK
  22 MKKKYLVAATGLALLGLSLSACSSNSSKGNSEKTTEQSKKKNKVISQN..KELREKFDQIKVGNF
  23 MIPLKKITVGTIVCLSFLGLTACSSSNTQQTSTSKSNVSQHKNIKADH..EELRLKFNKVKLGVK
  24 MKSKMKIIFSITMFFALVSVGVIKLNKENAAAYAAKGKALSHHMKNSV..KDKKYSMKK------
  25 -----------VLLIAFAALALTACSSKKATTDSESDKKAASSISSSNvvKQTSNKINLTNYKKI
  26 -----------VLLIAFAALALTACSSKKATTDSESDKKAASSISSSNvvKQNSNKINLTNYKKI
  27 -------------------------NSSKNDTKKESSEKKSEDKSKDN..SDLKATYDKINVGDI
  28 -------------------------NSSKNDTKKESSEKKSEDKSKDN..SDLKATYDKINVGDI
  29 ------LKIFGIFSTLFIVFFTC--------------KTFANDLSNSY..YTFNNCSPKQITYDN
  30 -----VLKIFGIFTTLFIVFFTC--------------RTFATDLSTSY..CTFNNCSPKQITYDN
  31 ------------------------------------------------..---------------
  32 ------------------------------------------------..---------------
  33 ------------------------------------------------..---------------
  34 ------------------------------------------------..---------------
  35 ------------------------------------------------..---------------
  36 ------------------------------------------------..---------------
  37 ------------------------------------------------..---------------
  38 ------------------------------------------------..---------------
  39 MIPLKKITVGTIVCLSFLGLTACSSSNTQQTSTSKSNVSQHKNIKADH..EELRLKFNKVKLGVK
  40 ------------------------------------------------..---------------
  41 ------------------------------------------------..---------------
  42 ------------------------------------------------..---------------
  43 ------------------------------------------------..---------------
  44 ------------------------------------------------..---------------
  45 ------------------------------------------------..---------------
  46 ---------------SAVALSLVACGDSTKEASNEKKEXPKQEAKKEN..KENKESKKKITAADV
  47 -------------LGSAVALSLVACGDSTKEASNEKKEEPKQEAKKEN..KENKESKKKITAADV
  48 ----------------------------------TKKYEEKNDRMPWY..KDVNNDSAEV-DYDD
  49 ------------------------------------------------..-------K-------


           70        80         90       100                 110       
           |         |          |         |                   |       
   1 QNHFSGGTSIEQLKQWFG.DPNKSEQRNAGNITLDSYTW.....VKDG.....AVINAQ.LYKNS
   2 DSSFTGGTSLEELISLFG.EPNQHDPKTAGEVTIDAYTW.....QFDQ.....VTLTVN.LYQNS
   3 ANNFKGGTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.....NVDD.....ISITIQ.LLNDS
   4 ANNFKGGTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.....NVDD.....ISITIQ.LLNDS
   5 DSSFTGGTSLEELISLFG.EPNQHDPKTAGEVTIDAYTW.....QFDQ.....VTLTVN.LYQNS
   6 DSSFTGGTSLEELISLFG.EPSQHDPKTAGEVTIDAYTW.....QFDQ.....VTLTVN.LYQNS
   7 DSSFTGGTSLEELISLFG.EPSQHDPKTAGEVTIDAYTW.....QFDQ.....VTLTVN.LYQNS
   8 DSSFTGGTSLEELISLFG.EPSQHDPKTAGEVTINAYTW.....QFDQ.....VTLTVN.LYQNS
   9 DSSFTGGTSLEELISLFG.EPSQHDPKTAGEVTIDAYTW.....QFDQ.....VTLTVN.LYQNS
  10 ANNFKGGTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.....NVDD.....ISITIQ.LLNDS
  11 QNHFSGGTSIEQLKQWFG.DPNKSEQRNAGNITLDSYTW.....VKDG.....AVINAQ.LYKNS
  12 FCKIKIGSTYEEVKSILG.EYKESKESEINGMKVVIYSW.....YNDDn....SNMEVI.VKNNK
  13 FCKIKIGSTYEEVKSILG.EYKESKESEINGMKVVIYSW.....YNDDn....SNMEVI.VKNNK
  14 FCKIKIGSTYEEVKSILG.EYKESKESEINDMKVVIYSW.....YNDDn....SNMEVI.VKNNK
  15 FCKIKIGSTYEEVKSILG.EYKESKESEIDGMKVVIYTW.....YNDDn....SNMEVI.VKNNK
  16 FCKIKIGSTYEEVKSILG.EYKESKESEINGMKVVIYTW.....YNDDn....SNMEVI.VKNNK
  17 FSKVKMGSTYEDVKNMLG.EAKESTSSEMGGIKTVIYTWd....NGDG.....SNMNVT.FQNNK
  18 FSKVKMGSTYEDVKNMLG.EGKESTSSEMGGIKTVIYTWd....NGDG.....SNMNVT.FQNNK
  19 SKHGEGGSTIQDVEKLLG.KANTTDTTTVESYKTKSYIW.....NKGA.....VTVTVQ.FEPDK
  20 SNHGEGGSTIQDVEKLLG.KANTTDTTTVDSYKTKSYIW.....NKGA.....VTVTVQ.FEPDK
  21 ANNFKGGTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.....NVDD.....ISITIQ.LLNDS
  22 LSQGEGGSTIDEVKQLLG.SPTSTTTTSSNGVKLKQLTW.....TKGA.....VTVAIQtLDSNK
  23 ANNFKGGTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.....NVDD.....ISITIQ.LLNDS
  24 FLRINMGMNYKSVENILG.VSEKTGQINDKRELMNHQWK.....NSDD.....SYIVVI.TKNNY
  25 KVVEKTGSTPSQVTDLLGrEADAKSKAKTSKLKATIYTWegvqnGSAG.....ANLAVE.FANGV
  26 KVVEKTGSTPSQVTDLLGrEADAKSKAKTSKLKATIYTWegvqnGSAG.....ANLAVE.FANGV
  27 MNSSEGGSTEDEVKAILG.EPASSSTTDIQGISTTTLSW.....TNVKggdllASITVS.FSDGK
  28 MNSSEGGSTEDEVKAILG.EPASSSTTDIQGISTTTLSW.....TNVKggdllASITVS.FSDGK
  29 FVKIEIGSNYNDVIKILG.KESYKDSTIINGLKNTTYIW.....KVNGte...KNIFIT.FRNGI
  30 FLKVEIGSNYNDVVKILG.KESYMDSAIINGLKNTTYIW.....KINGte...KNIFIT.FRNGI
  31 ------GSTYEEVKNMLG.EGKESTSSEMGGIKTVIYTWd....NGDG.....SNMNVT.FQNNK
  32 ------------------.--------------------.....----.....------.-----
  33 ------------------.--------------------.....----.....------.-----
  34 ------------------.--------------------.....----.....------.-----
  35 ------------------.--------------------.....----.....------.-----
  36 ------------------.--------------------.....----.....------.-----
  37 ------------------.--------------------.....----.....------.YLVKL
  38 ------------------.--------------------.....----.....------.-----
  39 ANNFKGGTSLAELT----.----------------IIWW.....RTNE.....XL----.-----
  40 ------------------.--------------------.....----.....------.-----
  41 ------------------.--------------------.....----.....------.-----
  42 ------------------.--------------------.....----.....------.-----
  43 ------------------.--------------------.....----.....------.-----
  44 ------------------.--------------------.....----.....------.-----
  45 ------------------.--------------------.....----.....------.-----
  46 -EAIKVGDS---------.--------------------.....----.....------.-----
  47 -EAIKVGDS---------.--------------------.....----.....------.-----
  48 YLKIKKGMSANQVKEAIG.KPRMIE--KYKSYSVYGYLG.....HGDK.....GSLRII.FDPNG
  49 ------------------.--------------------.....----.....------.-----


       120            130       140              150       160       17
        |              |         |                |         |         
   1 TVARSISNFSFS.....REAKIGKEDYDELKIG.....ESYKK..VVEKLGEPDVLSQSMSSDKE
   2 SIVKTISNFTFA.....RELGLSQKEYQQLQKG.....MSYED..VKKILTEPDNYSQASSSDHQ
   3 SIVRSISNFKFI.....RDANITTKDYNSLKNG.....MSYNK..VKELLGEPDDISQAVSSDKE
   4 SIVRSISNFKFI.....RDANITTKDYNSLKNG.....MSYNK..VKELLGEPDDISQAVSSDKE
   5 SIVKTISNFTFA.....RELGLSQKEYQQLQKG.....MSYED..VKKILTEPDNYSQASSSDHQ
   6 SIVKTISNFTFA.....RELGLSQKEYQQLQKG.....MSYED..VKKILTEPDNYSQASSSDHQ
   7 SIVKTISNFTFA.....RELGLSQKEYQQLQKG.....MSYED..VKKILTEPDNYSQASSSDHQ
   8 SIVKTISNFTFA.....RELGLSQKEYQQLQKG.....MSYED..AKKILTEPDNYSQASSSDHQ
   9 SIVKTISNFTFA.....RELGLSQKEYQQLQKR.....MSYED..VKKILTEPDNYSQASSSDHQ
  10 SIVRSISNFKFI.....RDANITTKDYNSLKNG.....MSYNK..VKELLGEPDDISQAVSSDKE
  11 TVARSISNFSFS.....REAKIGKEDYDELKIG.....ESYKK..VVEKLGEPDVLSQSMSSDKE
  12 VIGKAQAGLSMG.....K-ADVNLIKYAKITTG.....MDYSK..VEEILGDGKLMSISKTNGST
  13 VIGKAQAGLSMG.....K-ADVNLIKYAKITTG.....MDYSK..VEEILGDGKLMSISKTNGST
  14 VIGKAQAGLSMG.....K-ADVNLIKYAKITTG.....MDYSK..VEEILGDGKLMSISKTNGST
  15 VIGKAQAGLSMG.....K-ADVNLIKYTKIRTG.....MDYSK..VKEILGDGKLMSISKTNGST
  16 VIGKAQADLSMG.....K-ADVNLIKYAKITTG.....MDYSK..VEEILGDGKLMSISKTNGST
  17 ALAKAQAGLSRK.....R-ADVNMEKYNKIQTG.....MDYNK..VKEILGDGELMSISEVGGSN
  18 ALAKAQAGLSRE.....K-ADVNMEKYNTIQTG.....MDYNK..IKEILGAGELMSISEVGGSN
  19 VVTKDITGFKWGk....RDEKLDLAAFNSIQDG.....ASYDD..IVKKYGEPDSLNESLLLGTK
  20 AVTKDITGFKWGk....RDEKLDLAAFNSIQDG.....ATYDD..IVKKYGEPDSLNESLLLGTK
  21 SIVRSISNFKFI.....RDANITTKDYNSLKNG.....MSYNK..VKELLGEPDDISQAVSSDKE
  22 VVSKEITGFKWGk....RDEKLTLGEFNNIADG.....STYQS..LVDKYGEPDGLHEANVAGTK
  23 SIVRSISNFKFI.....RDANITTKDYNSLKNX.....XSYNK..VKELLGEPDDISQA------
  24 VVSKIEIGLE-K.....INANISRVKYKKISRG.....MSYEK..VKNLVGKGELLSETNLMGSN
  25 AIAKQISGLVVN.....RSKQITPKDYKSLKKG.....MTQEE..VEAIVGKPNGYSESDYSNSE
  26 AIAKQISGLVVN.....RSKQITPKDYKSLKKG.....MTQEE..VEAIVGKPNGYSESDYSNSE
  27 AASKSVSGLKVA.....KHDKVTADQVNNIATD.....GSYSEeqARKDLGDPTGITSTNINGEK
  28 AASKSVSGLKVA.....KHDKVTADQVNNIATD.....GSYSEeqARKDLGDPTGITSTNINGEK
  29 VITKEQYKLNDN.....F-SVLSSEKISSLKKG.....MSYDE..AKNILGEGILRSEEKGIKVF
  30 VITKEQYKLN-D.....KFSILSNKKINSLKKG.....MSYNE..VKNILGEGILRSEEKE----
  31 ALAKAQAGLSRE.....R-ADVNAEKYNRIQTG.....MDYNK..VKEILGDGE-----------
  32 -VSPEAPNTSGD.....NETVITKENYDKVKNG.....MSYEE..VVKIIGSEGEIVTETGEKGD
  33 --------LPLA.....GCNKLTPENYDKLRMG.....MHYAE..VKSILGEPTRCSD-------
  34 ------------.....-CSKLTMENYSKIKTG.....IGYTE..VVKILGKPDNCSEA------
  35 ------------.....GCSKLTTENYEKIKMG.....MDYGE..VAGILGKPDSCSEA------
  36 ------------.....GCSKLTQENYAKLKMG.....LGYGE..VVTILGKPDSCSEA------
  37 AIAIVLSAFLFG.....CFSKINQENYAKIENG.....MTMEQ..VKDILGEPTESQTAGIGSLS
  38 ------------.....--SKVTVENYDKIRVG.....MTYDE..VKQLLGAPNRCSDV------
  39 ------------.....----------------.....-----..--------------------
  40 ------------.....---------YEDLKNG.....TSYDN..AVKILGVPDVYSIAVSSDAT
  41 ------------.....---------YEDLKNG.....TSYDN..AVKTLGVPDVYSIAVSSDAT
  42 ------------.....---------YEDLKNG.....TSYDN..AVQTLGVPDVYSIAVSSDAT
  43 ------------a....CENKVTRENYDKLAIG.....MEYSK..VVELLGEPENCQSV------
  44 ------------.....--ELVSQEKYKQLKLD.....MSYED..VKKIMGSPGKVKKFPGQPST
  45 ------------.....----VYMEEYDKIEVG.....ISANK..VKELIGEPSDIEKYKSYSLY
  46 --------LTG-.....-------------AGG.....EKYED..VVAKFGEPDNKAESQAGDIK
  47 --------LTG-.....-------------AGG.....EKYED..VVAKFGEPDNKAESQAGDIK
  48 TVTKIEENGLRHq14nqQSHPVSLDMFESIKIG.....MTADE..VTEIVGTS------------
  49 ------------.....--KKITVADVDTIKTGdp8ggDKYED..LVAKYGEPDIKSDSTSKNVK


      0       180        190        200      
     |         |          |          |      
   1 EMQTVWSSGIKTKSSSA.TIELYF.ENGLLKNKTQKDLE
   2 TLQAIWVSGLKTDTSGA.NISLVF.ENNQLTEMSQVGLE
   3 ELQAAWISGIQSSDSDP.GINLTF.ENDKLTNKQQHGLK
   4 ELQAAWISGIQSSDSDP.GINLTF.ENDKLTNKQQHGLK
   5 TLQAIWVSGLKTDTSGA.NISLVF.ENNQLTEMSQVGLE
   6 TLQAIWVSGLKTDTSGA.NISLVF.ENNQLTEMSQVGLE
   7 TLQAIWVSGLKTDTSGA.NISLVF.ENNQLTEMSQVGLE
   8 TLQAIWVSGLKTDTSGA.NISLVF.ENNQLTEMSQVGLE
   9 TLQAIWVSGLKTDTSGA.NISLVF.ENNQLTEMSQVGLE
  10 ELQAAWISGIQSSDSDP.GINLTF.ENDKLTNKQQHGLK
  11 EMQTVWSSGIKTKSSSA.TIELYF.ENGLLKNKTQKDLE
  12 KSIYLWA-----NPNGT.NMNVTF.QNGKVTAKNRLGL-
  13 KSIYLWA-----NPNGT.NMNVTF.QNGKVTAKNRLGL-
  14 KSIYLWA-----NPNGT.NMNVTF.QNGKVTAKNRLGL-
  15 KSIYLWA-----NPNGT.NMNVTF.QNGKVTTKNRLGL-
  16 KSIYLWA-----NPNGT.NMNVTF.QNGKVTAKNRLGL-
  17 TSIYSWV-----NSNGT.NINVTF.QDGKSAAKAQFGLK
  18 TSIYSWV-----NSNGT.NMNVTF.QDGKSAAKAQFGLK
  19 TVTALWYTGIKGKGAGA.NASLTF.ENGALTSKTQTDLK
  20 TVTGLWYTGIKGKADGA.FASLTF.ENGALTSKTQTDLK
  21 ELQAAWISGIQSSDSDP.GINLTF.ENDKLTNKQQHGLK
  22 ITNAVWLTGIK-GDDGA.SATFSF.ENDKLSSKTQTKLK
  23 -----------------.------.--------------
  24 SKMYQWV-----NSDGS.SMNITF.TNGIVDYKTEKKLK
  25 VVLWLYTSGLK-SDDQA.NFYVTF.QKNKLVAKKAQN--
  26 VVLWLYTSGLK-SDDQA.NFYVTF.QKNKLVAKKAQN--
  27 NDTLIWMKNLD-GDLGA.TVTVSF.SNGSAISKSSSGLK
  28 NDTLIWMKNLD-GDLGA.TVTVSF.SNGNAISKSSSGLK
  29 TWF---------DNNSK.YLNCTF.KNDKLTI-------
  30 TQVYSWF-----NNDSS.YINCTF.KNDKL---------
  31 -----------------.------.--------------
  32 DMYGIAVLYENKGSSLS.NATFIF.LGDKLQSKSQYGLE
  33 ---LLAVKACTWGDDAR.YINVNF.VADQAVLLNSSNLR
  34 ----LFVRNCVWGNEQK.NITVSF.VGDKAILFSSKNIK
  35 ----LFAKSCIWGNEQK.NITVNF.VGDKTILFTSKNIR
  36 ----LFAKSCVWGDEQK.NITVNF.AGDRVVLFTSTNIR
  37 GTNAIW------KSDSV.TIKLTF.VNSKVQLK------
  38 ----MTVKSCTWGDEKR.HVQVSF.VADQVVLFSSENLR
  39 -----------------.------.--------------
  40 MTQALWSSNLVTKKGKTgSLTLNF.KNGTLENKSQENL-
  41 MTQALWSSNLVTKKGKTgSLTLNF.KNGTLENKSQENL-
  42 MTQALWSSNLVTKKGKTgSLTLNF.KNGTLENKSQENL-
  43 ----VSVKSCVWGKTPK.TISVQF.VGEKILFYSNTG--
  44 ETTYVWK----QKNSSY.RILVTL.KDGKV---------
  45 RYG--------GWDSKG.EMTVYFdKNGTVTKKEQNGLR
  46 MIIASWTKNVN-GDLGA.NFNVTF.T-------------
  47 MIIASWTKNVN-GDLGA.NFNVTF.T-------------
  48 -----------------.------.--------------
  49 TYTASWSKNAK-GGTGA.NFTVSF.I-------------