a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0399
- gi|139473649|ref|YP_001128365.1|_3:205 putative lipoprotein [Streptococcus pyogenes str. Manfredo]
- gi|134271896|emb|CAM30134.1| putative lipoprotein [Streptococcus pyogenes str. Manfredo]
- gi|94994542|ref|YP_602640.1|_3:205 phage protein [Streptococcus pyogenes MGAS10750]
- gi|94548050|gb|ABF38096.1| phage protein [Streptococcus pyogenes MGAS10750]
- gi|15675243|ref|NP_269417.1|_3:205 hypothetical protein SPy_1290 [Streptococcus pyogenes M1 GAS]
- gi|56808027|ref|ZP_00365829.1| COG2352: Phosphoenolpyruvate carboxylase [Streptococcus pyogenes M49 591]
- gi|71903700|ref|YP_280503.1| hypothetical protein M28_Spy1035 [Streptococcus pyogenes MGAS6180]
- gi|71910867|ref|YP_282417.1| hypothetical protein M5005_Spy_1054 [Streptococcus pyogenes phage 5005.1]
- gi|94988730|ref|YP_596831.1| phage protein [Streptococcus pyogenes MGAS9429]
- gi|94990619|ref|YP_598719.1| phage protein [Streptococcus pyogenes MGAS10270]
- gi|94992553|ref|YP_600652.1| phage protein [Streptococcus pyogenes MGAS2096]
- gi|13622414|gb|AAK34138.1| hypothetical protein SPy_1290 [Streptococcus pyogenes M1 GAS]
- gi|71802795|gb|AAX72148.1| hypothetical protein M28_Spy1035 [Streptococcus pyogenes MGAS6180]
- gi|71853649|gb|AAZ51672.1| hypothetical protein M5005_Spy1054 [Streptococcus pyogenes phage 5005.1]
- gi|94542238|gb|ABF32287.1| phage protein [Streptococcus pyogenes MGAS9429]
- gi|94544127|gb|ABF34175.1| phage protein [Streptococcus pyogenes MGAS10270]
- gi|94546061|gb|ABF36108.1| phage protein [Streptococcus pyogenes MGAS2096]
- gi|19746281|ref|NP_607417.1|_3:205 hypothetical protein spyM18_1310 [Streptococcus pyogenes MGAS8232]
- gi|19748469|gb|AAL97916.1| hypothetical protein [Streptococcus pyogenes MGAS8232]
- gi|76787941|ref|YP_329852.1|_1:207 hypothetical protein SAK_1235 [Streptococcus agalactiae A909]
- gi|77414874|ref|ZP_00790984.1| putative lipoprotein [Streptococcus agalactiae 515]
- gi|76562998|gb|ABA45582.1| conserved hypothetical protein [Streptococcus agalactiae A909]
- gi|77159075|gb|EAO70276.1| putative lipoprotein [Streptococcus agalactiae 515]
- gi|22537307|ref|NP_688158.1|_1:207 lipoprotein, putative [Streptococcus agalactiae 2603V/R]
- gi|25011265|ref|NP_735660.1| hypothetical protein gbs1216 [Streptococcus agalactiae NEM316]
- gi|76798884|ref|ZP_00781091.1| lipoprotein, putative [Streptococcus agalactiae 18RS21]
- gi|77406670|ref|ZP_00783712.1| lipoprotein, putative [Streptococcus agalactiae H36B]
- gi|22534177|gb|AAN00031.1|AE014244_8 lipoprotein, putative [Streptococcus agalactiae 2603V/R]
- gi|23095689|emb|CAD46875.1| unknown [Streptococcus agalactiae NEM316]
- gi|76585753|gb|EAO62304.1| lipoprotein, putative [Streptococcus agalactiae 18RS21]
- gi|77174711|gb|EAO77538.1| lipoprotein, putative [Streptococcus agalactiae H36B]
- gi|50914374|ref|YP_060346.1|_3:205 unknown phage protein [Streptococcus pyogenes MGAS10394]
- gi|50903448|gb|AAT87163.1| unknown phage protein [Streptococcus pyogenes MGAS10394]
- gi|21910515|ref|NP_664783.1|_3:205 hypothetical protein SpyM3_0979 [Streptococcus pyogenes MGAS315]
- gi|28895787|ref|NP_802137.1| hypothetical protein SPs0875 [Streptococcus pyogenes SSI-1]
- gi|21904715|gb|AAM79586.1| conserved hypothetical protein [Streptococcus pyogenes MGAS315]
- gi|28811036|dbj|BAC63970.1| hypothetical protein [Streptococcus pyogenes SSI-1]
- gi|76800382|ref|ZP_00782023.1|_5:200 conserved hypothetical protein [Streptococcus agalactiae 18RS21]
- gi|76584418|gb|EAO61382.1| conserved hypothetical protein [Streptococcus agalactiae 18RS21]
- gi|24379624|ref|NP_721579.1|_1:206 hypothetical protein SMU.1196c [Streptococcus mutans UA159]
- gi|24377575|gb|AAN58885.1|AE014956_6 conserved hypothetical protein [Streptococcus mutans UA159]
- gi|153941070|ref|YP_001391563.1|_1:197 hypothetical protein CLI_2313 [Clostridium botulinum F str. Langeland]
- gi|170754377|ref|YP_001781875.1| conserved hypothetical protein [Clostridium botulinum B1 str. Okra]
- gi|152936966|gb|ABS42464.1| conserved hypothetical protein [Clostridium botulinum F str. Langeland]
- gi|169119589|gb|ACA43425.1| conserved hypothetical protein [Clostridium botulinum B1 str. Okra]
- gi|168180788|ref|ZP_02615452.1|_1:197 conserved hypothetical protein [Clostridium botulinum NCTC 2916]
- gi|182668531|gb|EDT80510.1| conserved hypothetical protein [Clostridium botulinum NCTC 2916]
- gi|148380213|ref|YP_001254754.1|_1:197 membrane protein [Clostridium botulinum A str. ATCC 3502]
- gi|153931015|ref|YP_001384517.1| hypothetical protein CLB_2204 [Clostridium botulinum A str. ATCC 19397]
- gi|153935786|ref|YP_001388033.1| hypothetical protein CLC_2187 [Clostridium botulinum A str. Hall]
- gi|148289697|emb|CAL83802.1| putative membrane protein [Clostridium botulinum A str. ATCC 3502]
- gi|152927059|gb|ABS32559.1| conserved hypothetical protein [Clostridium botulinum A str. ATCC 19397]
- gi|152931700|gb|ABS37199.1| conserved hypothetical protein [Clostridium botulinum A str. Hall]
- gi|168183887|ref|ZP_02618551.1|_1:197 conserved hypothetical protein [Clostridium botulinum Bf]
- gi|182672946|gb|EDT84907.1| conserved hypothetical protein [Clostridium botulinum Bf]
- gi|170759226|ref|YP_001787641.1|_1:197 conserved hypothetical protein [Clostridium botulinum A3 str. Loch Maree]
- gi|169406215|gb|ACA54626.1| conserved hypothetical protein [Clostridium botulinum A3 str. Loch Maree]
- gi|148380245|ref|YP_001254786.1|_1:198 membrane protein [Clostridium botulinum A str. ATCC 3502]
- gi|153934157|ref|YP_001384550.1| hypothetical protein CLB_2239 [Clostridium botulinum A str. ATCC 19397]
- gi|153934734|ref|YP_001388066.1| hypothetical protein CLC_2222 [Clostridium botulinum A str. Hall]
- gi|148289729|emb|CAL83834.1| putative membrane protein [Clostridium botulinum A str. ATCC 3502]
- gi|152930201|gb|ABS35701.1| conserved hypothetical protein [Clostridium botulinum A str. ATCC 19397]
- gi|152930648|gb|ABS36147.1| conserved hypothetical protein [Clostridium botulinum A str. Hall]
- gi|168183929|ref|ZP_02618593.1|_1:198 conserved hypothetical protein [Clostridium botulinum Bf]
- gi|182672990|gb|EDT84951.1| conserved hypothetical protein [Clostridium botulinum Bf]
- gi|90592577|ref|YP_529837.1|_1:207 hypothetical protein LGPKV5a_gp02 [Lactobacillus phage KC5a]
- gi|89891906|gb|ABD78779.1| hypothetical protein [Lactobacillus gasseri phage KC5a]
- gi|116629235|ref|YP_814407.1|_1:207 hypothetical protein LGAS_0573 [Lactobacillus gasseri ATCC 33323]
- gi|116629295|ref|YP_814467.1| hypothetical protein LGAS_0635 [Lactobacillus gasseri ATCC 33323]
- gi|116094817|gb|ABJ59969.1| hypothetical protein LGAS_0573 [Lactobacillus gasseri ATCC 33323]
- gi|116094877|gb|ABJ60029.1| hypothetical protein LGAS_0635 [Lactobacillus gasseri ATCC 33323]
- gi|77409729|ref|ZP_00786389.1|_3:155 lipoprotein, putative [Streptococcus agalactiae COH1]
- gi|77171657|gb|EAO74866.1| lipoprotein, putative [Streptococcus agalactiae COH1]
- gi|163932154|ref|YP_001642344.1|_1:207 hypothetical protein LJ771_002 [Lactobacillus johnsonii prophage Lj771]
- gi|163562108|gb|ABY26964.1| hypothetical protein LJ771_002 [Lactobacillus johnsonii prophage Lj771]
- gi|77412739|ref|ZP_00788973.1|_1:164 lipoprotein, putative [Streptococcus agalactiae CJB111]
- gi|77161209|gb|EAO72286.1| lipoprotein, putative [Streptococcus agalactiae CJB111]
- gi|15895876|ref|NP_349225.1|_1:194 Hypothetical protein, CF-17 family [Clostridium acetobutylicum ATCC 824]
- gi|15025643|gb|AAK80565.1|AE007759_3 Hypothetical protein, CF-17 family [Clostridium acetobutylicum ATCC 824]
- gi|116513968|ref|YP_812874.1|_6:204 hypothetical protein LBUL_0831 [Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365]
- gi|116093283|gb|ABJ58436.1| hypothetical protein LBUL_0831 [Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365]
- gi|104773961|ref|YP_618941.1|_6:204 hypothetical protein Ldb0913 [Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842]
- gi|103423042|emb|CAI97733.1| Conserved hypothetical protein [Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842]
- gi|29376973|ref|NP_816127.1|_62:247 hypothetical protein EF2480 [Enterococcus faecalis V583]
- gi|29344438|gb|AAO82197.1| conserved hypothetical protein [Enterococcus faecalis V583]
- gi|3341433|emb|CAA76857.1|_62:247 hypothetical protein [Enterococcus faecalis]
- gi|118442880|ref|YP_878434.1|_6:177 hypothetical protein NT01CX_2361 [Clostridium novyi NT]
- gi|118133336|gb|ABK60380.1| conserved hypothetical protein [Clostridium novyi NT]
- gi|168186573|ref|ZP_02621208.1|_6:175 conserved hypothetical protein [Clostridium botulinum C str. Eklund]
- gi|169295492|gb|EDS77625.1| conserved hypothetical protein [Clostridium botulinum C str. Eklund]
- gi|168180750|ref|ZP_02615414.1|_2:90 putative membrane protein [Clostridium botulinum NCTC 2916]
- gi|182668464|gb|EDT80443.1| putative membrane protein [Clostridium botulinum NCTC 2916]
- gi|169185903|ref|ZP_02846065.1|_44:132 hypothetical protein Pjdr2DRAFT_1172 [Paenibacillus sp. JDR-2]
- gi|169007324|gb|EDS54173.1| hypothetical protein Pjdr2DRAFT_1172 [Paenibacillus sp. JDR-2]
- gi|148262331|ref|YP_001229037.1|_19:86 hypothetical protein Gura_0248 [Geobacter uraniumreducens Rf4]
- gi|146395831|gb|ABQ24464.1| hypothetical protein Gura_0248 [Geobacter uraniireducens Rf4]
- gi|119898520|ref|YP_933733.1|_11:82 conserved hypothetical secreted protein [Azoarcus sp. BH72]
- gi|119670933|emb|CAL94846.1| conserved hypothetical secreted protein [Azoarcus sp. BH72]
- gi|118579387|ref|YP_900637.1|_18:86 hypothetical protein Ppro_0950 [Pelobacter propionicus DSM 2379]
- gi|118502097|gb|ABK98579.1| conserved hypothetical protein [Pelobacter propionicus DSM 2379]
- gi|110602381|ref|ZP_01390485.1|_18:85 conserved hypothetical protein of beta-lactamase-inhibitor family (Pfam) [Geobacter sp. FRC-32]
- gi|110546907|gb|EAT60229.1| conserved hypothetical protein of beta-lactamase-inhibitor family (Pfam) [Geobacter sp. FRC-32]
- gi|153879384|ref|ZP_02004811.1|_7:89 conserved hypothetical protein [Beggiatoa sp. PS]
- gi|152064152|gb|EDN65189.1| conserved hypothetical protein [Beggiatoa sp. PS]
- gi|56478050|ref|YP_159639.1|_21:86 hypothetical protein of beta-lactamase-inhibitor family (Pfam) [Azoarcus sp. EbN1]
- gi|56314093|emb|CAI08738.1| hypothetical protein of beta-lactamase-inhibitor family (Pfam) [Azoarcus sp. EbN1]
- gi|77412604|ref|ZP_00788889.1|_1:86 lipoprotein, putative [Streptococcus agalactiae CJB111]
- gi|77161344|gb|EAO72370.1| lipoprotein, putative [Streptococcus agalactiae CJB111]
- gi|116627483|ref|YP_820102.1|_2:70 hypothetical protein STER_0643 [Streptococcus thermophilus LMD-9]
- gi|116100760|gb|ABJ65906.1| Uncharacterized conserved protein [Streptococcus thermophilus LMD-9]
- gi|55822564|ref|YP_141005.1|_4:72 hypothetical protein str0594 [Streptococcus thermophilus CNRZ1066]
- gi|55738549|gb|AAV62190.1| unknown protein [Streptococcus thermophilus CNRZ1066]
- gi|55820673|ref|YP_139115.1|_4:72 hypothetical protein stu0594 [Streptococcus thermophilus LMG 18311]
- gi|55736658|gb|AAV60300.1| unknown protein [Streptococcus thermophilus LMG 18311]
- gi|53802384|ref|YP_112844.1|_23:89 lipoprotein, putative [Methylococcus capsulatus str. Bath]
- gi|53756145|gb|AAU90436.1| putative lipoprotein [Methylococcus capsulatus str. Bath]
- gi|158335308|ref|YP_001516480.1|_49:113 hypothetical protein AM1_2152 [Acaryochloris marina MBIC11017]
- gi|158305549|gb|ABW27166.1| conserved hypothetical protein [Acaryochloris marina MBIC11017]
- gi|47568759|ref|ZP_00239454.1|_92:157 conserved hypothetical protein protein [Bacillus cereus G9241]
- gi|47554539|gb|EAL12895.1| conserved hypothetical protein protein [Bacillus cereus G9241]
- gi|65318347|ref|ZP_00391306.1|_14:121 COG0124: Histidyl-tRNA synthetase [Bacillus anthracis str. A2012]
- gi|30261065|ref|NP_843442.1|_14:121 lipoprotein, putative [Bacillus anthracis str. Ames]
- gi|47526221|ref|YP_017571.1| lipoprotein, putative [Bacillus anthracis str. 'Ames Ancestor']
- gi|49183906|ref|YP_027158.1| lipoprotein, putative [Bacillus anthracis str. Sterne]
- gi|165871673|ref|ZP_02216318.1| putative lipoprotein [Bacillus anthracis str. A0488]
- gi|167635450|ref|ZP_02393763.1| putative lipoprotein [Bacillus anthracis str. A0442]
- gi|167638978|ref|ZP_02397252.1| putative lipoprotein [Bacillus anthracis str. A0193]
- gi|168172973|ref|ZP_02608202.1| lipoprotein, putative [Bacillus anthracis Tsiankovskii-I]
- gi|170687557|ref|ZP_02878773.1| putative lipoprotein [Bacillus anthracis str. A0465]
- gi|170707981|ref|ZP_02898430.1| putative lipoprotein [Bacillus anthracis str. A0389]
- gi|177653558|ref|ZP_02935732.1| putative lipoprotein [Bacillus anthracis str. A0174]
- gi|30254679|gb|AAP24928.1| lipoprotein, putative [Bacillus anthracis str. Ames]
- gi|47501369|gb|AAT30045.1| lipoprotein, putative [Bacillus anthracis str. 'Ames Ancestor']
- gi|49177833|gb|AAT53209.1| lipoprotein, putative [Bacillus anthracis str. Sterne]
- gi|164712574|gb|EDR18106.1| putative lipoprotein [Bacillus anthracis str. A0488]
- gi|167513108|gb|EDR88480.1| putative lipoprotein [Bacillus anthracis str. A0193]
- gi|167529068|gb|EDR91822.1| putative lipoprotein [Bacillus anthracis str. A0442]
- gi|170127141|gb|EDS96019.1| putative lipoprotein [Bacillus anthracis str. A0389]
- gi|170668370|gb|EDT19117.1| putative lipoprotein [Bacillus anthracis str. A0465]
- gi|172081362|gb|EDT66436.1| putative lipoprotein [Bacillus anthracis str. A0174]
- gi|47568759|ref|ZP_00239454.1|_185:321 conserved hypothetical protein protein [Bacillus cereus G9241]
- gi|47554539|gb|EAL12895.1| conserved hypothetical protein protein [Bacillus cereus G9241]
- gi|168135486|ref|ZP_02578715.1|_53:127 lipoprotein, putative [Bacillus cereus B4264]

              10        20        30        40        50        60     
              |         |         |         |         |         |     
   1 MSMKKTKNWLLVFLTVTFCFLMLGCQSKEDKKGGTKPSNEAALTKTENLDFRLSFNKIKVTTDQN
   2 ---KKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEIITPRLHQAAHQDKRANFEKIKLATVDS
   3 ---KKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSENITPRLHQAAHQDKRANFEKIKLATVDS
   4 ---KKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEIITPRLHQAAHQDKRANFEKIKLATVDS
   5 ---KKHLLTLLLISFFTSFLVACSTTKDKKPQPSDSEIITPRLHQAAHQDKRANFEKIKLATVDS
   6 MIPLKKITVGTIICLSFLGLTACSSSNTQQTSTSKSNVSQHKNIKADHEELRLKFNKVKLGVKAN
   7 MIPLKKITVGTIVCLSFLGLTACSSSNTQQTSTSKSNVSQHKNIKADHEELRLKFNKVKLGVKAN
   8 ---KKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEIITPRLHQAAHQDKRANFEKIKLATVDS
   9 ---KKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSEIITPRLHQAAHQDKRANFEKIKLATVDS
  10 -----------IVCLSFLGLTACSSSNTQQTXTSKSNVSQHKNIKADHEELRLKFNKVKLGVKAN
  11 MSMKKTKNWLLVFLTVTFCFLMLGCQSKEDKKGGTKPSNEAALTKTENLDFRLSFNKIKVTTDQN
  12 MLEKKEEPFYKKIWFWIIAIVIVCGVASYGDSKKINITDTKNSAKT---ETKKDDTRKVTYEKFC
  13 MLEKKEEPFYKKIWFWIIAIVIICGVASYGDSKKINITDTKNSDKT---EIKKDDTRKVTYEKFC
  14 MLEKKEEPFYKKIWFWIIAIVIVCGVASYGDSKKINITDTKNSAKT---DTKKDDTRKVTYEKFC
  15 MLEEKDEPFYKKIWFWIIAIVIVFGVASYGGSKKINITDTKNSPKT---EIKKDDTRKVTYEKFC
  16 MLEKKEEPFYKKIWFWIIAMVIVFGVANYGGSKKINIIDTKNSSET---GIKKDDTRKVTYEKFC
  17 MSKKAKKPFYKKFWIWIIAIIIIGGVIGSNGSKKTGNTSNNSSTKK---EAKKEDTRKITYEKFS
  18 MSKRVKKPFYKKFWFWIIAIIIIGGVIGSNGSKKTGNTSNNNSTKK---EAKKEDTRKITYEKFS
  19 MKKKYLVAATGLALLGLSMSACSSNSGSKSDSATTSQQKKKNETISQNKELREKFDQVKVGELSK
  20 MKKKYLVAATGLALLGLSMSACSSNSGSKSDSAKTSQKKKKNETISQNKELREKFDQIKVGELSN
  21 ------------------------------------------------------FNKVKLGVKAN
  22 MKKKYLVAATGLALLGLSLSACSSNSSKGNSEKTTEQSKKKNKVISQNKELREKFDQIKVGNFLS
  23 MIPLKKITVGTIVCLSFLGLTACSSSNTQQTSTSKSNVSQHKNIKADHEELRLKFNKVKLGVKAN
  24 MKSKMKIIFSITMFFALVSVGVIKLNKENAAAYAAKGKALSHHMKNSVKDKKYSMKK------FL
  25 ----------LLIAFAALALTACSSKKATTDSESDKKAASSISSSNVVKQTSNKINLTNYKKIKV
  26 ----------LLIAFAALALTACSSKKATTDSESDKKAASSISSSNVVKQNSNKINLTNYKKIKV
  27 --------------------------SSKNDTKKESSEKKSEDKSKDNSDLKATYDKINVGDIMN
  28 --------------------------SSKNDTKKESSEKKSEDKSKDNSDLKATYDKINVGDIMN
  29 -----FLKIFGIFSTLFIVFFTCKTF--------------ANDLSNSYYTFNNCSPKQITYDNFV
  30 -----VLKIFGIFTTLFIVFFTCRTF--------------ATDLSTSYCTFNNCSPKQITYDNFL
  31 -----------------------------------------------------------------
  32 -----------------------------------------------------------------
  33 -----------------------------------------------------------------
  34 -----------------------------------------------------------------
  35 -----------------------------------------------------------------
  36 -----------------------------------------------------------------
  37 -----------------------------------------------------------------
  38 -----------------------------------------------------------------
  39 MIPLKKITVGTIVCLSFLGLTACSSSNTQQTSTSKSNVSQHKNIKADHEELRLKFNKVKLGVKAN
  40 -----------------------------------------------------------------
  41 -----------------------------------------------------------------
  42 -----------------------------------------------------------------
  43 -----------------------------------------------------------------
  44 -----------------------------------------------------------------
  45 -----------------------------------------------------------------
  46 -----------------VALSLVACGDSTKEASNEKKEXPKQEAKKENKENKESKKKITAADV-E
  47 ---------------VALSLVACGD--STKEASNEKKEEPKQEAKKENKENKESKKKITAADV-E
  48 ---------------------------------DTKKYEEKNDRMPWYKDVNNDSAEV-DYDDYL
  49 ---------------------------------------------------KKDDKK--------


         70        80         90       100                 110        1
         |         |          |         |                   |         
   1 HFSGGTSIEQLKQWFG.DPNKSEQRNAGNITLDSYTW.....VKDG.....AVINAQ.LYKNSTV
   2 SFTGGTSLEELISLFG.EPNQHDPKTAGEVTIDAYTW.....QFDQ.....VTLTVN.LYQNSSI
   3 SFTGGTSLEELISLFG.EPNQHDPKTAGEVTIDAYTW.....QFDQ.....VTLTVN.LYQNSSI
   4 SFTGGTSLEELISLFG.EPSQHDPKTAGEVTIDAYTW.....QFDQ.....VTLTVN.LYQNSSI
   5 SFTGGTSLEELISLFG.EPSQHDPKTAGEVTIDAYTW.....QFDQ.....VTLTVN.LYQNSSI
   6 NFKGGTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.....NVDD.....ISITIQ.LLNDSSI
   7 NFKGGTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.....NVDD.....ISITIQ.LLNDSSI
   8 SFTGGTSLEELISLFG.EPSQHDPKTAGEVTINAYTW.....QFDQ.....VTLTVN.LYQNSSI
   9 SFTGGTSLEELISLFG.EPSQHDPKTAGEVTIDAYTW.....QFDQ.....VTLTVN.LYQNSSI
  10 NFKGGTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.....NVDD.....ISITIQ.LLNDSSI
  11 HFSGGTSIEQLKQWFG.DPNKSEQRNAGNITLDSYTW.....VKDG.....AVINAQ.LYKNSTV
  12 KIKIGSTYEEVKSILG.EYKESKESEINGMKVVIYSW.....YNDDn....SNMEVI.VKNNKVI
  13 KIKIGSTYEEVKSILG.EYKESKESEINGMKVVIYSW.....YNDDn....SNMEVI.VKNNKVI
  14 KIKIGSTYEEVKSILG.EYKESKESEINDMKVVIYSW.....YNDDn....SNMEVI.VKNNKVI
  15 KIKIGSTYEEVKSILG.EYKESKESEIDGMKVVIYTW.....YNDDn....SNMEVI.VKNNKVI
  16 KIKIGSTYEEVKSILG.EYKESKESEINGMKVVIYTW.....YNDDn....SNMEVI.VKNNKVI
  17 KVKMGSTYEDVKNMLG.EAKESTSSEMGGIKTVIYTWd....NGDG.....SNMNVT.FQNNKAL
  18 KVKMGSTYEDVKNMLG.EGKESTSSEMGGIKTVIYTWd....NGDG.....SNMNVT.FQNNKAL
  19 HGEGGSTIQDVEKLLG.KANTTDTTTVESYKTKSYIW.....NKGA.....VTVTVQ.FEPDKVV
  20 HGEGGSTIQDVEKLLG.KANTTDTTTVDSYKTKSYIW.....NKGA.....VTVTVQ.FEPDKAV
  21 NFKGGTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.....NVDD.....ISITIQ.LLNDSSI
  22 QGEGGSTIDEVKQLLG.SPTSTTTTSSNGVKLKQLTW.....TKGA.....VTVAIQtLDSNKVV
  23 NFKGGTSLAELKQLFGgEPNEKFDTPAGNVTLKGYRW.....NVDD.....ISITIQ.LLNDSSI
  24 RINMGMNYKSVENILG.VSEKTGQINDKRELMNHQWK.....NSDD.....SYIVVI.TKNNYVV
  25 VEKTGSTPSQVTDLLGrEADAKSKAKTSKLKATIYTWegvqnGSAG.....ANLAVE.FANGVAI
  26 VEKTGSTPSQVTDLLGrEADAKSKAKTSKLKATIYTWegvqnGSAG.....ANLAVE.FANGVAI
  27 SSEGGSTEDEVKAILG.EPASSSTTDIQGISTTTLSW.....TNVKggdllASITVS.FSDGKAA
  28 SSEGGSTEDEVKAILG.EPASSSTTDIQGISTTTLSW.....TNVKggdllASITVS.FSDGKAA
  29 KIEIGSNYNDVIKILG.KESYKDSTIINGLKNTTYIW.....KVNGte...KNIFIT.FRNGIVI
  30 KVEIGSNYNDVVKILG.KESYMDSAIINGLKNTTYIW.....KINGte...KNIFIT.FRNGIVI
  31 ----GSTYEEVKNMLG.EGKESTSSEMGGIKTVIYTWd....NGDG.....SNMNVT.FQNNKAL
  32 ----------------.--------------------.....----.....------.------V
  33 ----------------.--------------------.....----.....------.-------
  34 ----------------.--------------------.....----.....------.-------
  35 ----------------.--------------------.....----.....------.-------
  36 ----------------.--------------------.....----.....------.-------
  37 ----------------.--------------------.....----.....------.YLVKLAI
  38 ----------------.--------------------.....----.....------.-------
  39 NFKGGTSLAELT----.----------------IIWW.....RTNE.....X-----.-------
  40 ----------------.--------------------.....----.....------.-------
  41 ----------------.--------------------.....----.....------.-------
  42 ----------------.--------------------.....----.....------.-------
  43 ----------------.--------------------.....----.....------.-------
  44 ----------------.--------------------.....----.....------.-------
  45 ----------------.--------------------.....----.....------.-------
  46 AIKVGDSL--------.--------------------.....----.....------.-------
  47 AIKVGDSL--------.--------------------.....----.....------.-------
  48 KIKKGMSANQVKEAIG.KPRMIE--KYKSYSVYGYLG.....HGDK.....GSLRII.FDPNGTV
  49 ----------------.--------------------.....----.....------.-------


      20            130       140              150       160       170 
      |              |         |                |         |         | 
   1 ARSISNFSFS.....REAKIGKEDYDELKIG.....ESYKK..VVEKLGEPDVLSQSMSSDKEEM
   2 VKTISNFTFA.....RELGLSQKEYQQLQKG.....MSYED..VKKILTEPDNYSQASSSDHQTL
   3 VKTISNFTFA.....RELGLSQKEYQQLQKG.....MSYED..VKKILTEPDNYSQASSSDHQTL
   4 VKTISNFTFA.....RELGLSQKEYQQLQKG.....MSYED..VKKILTEPDNYSQASSSDHQTL
   5 VKTISNFTFA.....RELGLSQKEYQQLQKG.....MSYED..VKKILTEPDNYSQASSSDHQTL
   6 VRSISNFKFI.....RDANITTKDYNSLKNG.....MSYNK..VKELLGEPDDISQAVSSDKEEL
   7 VRSISNFKFI.....RDANITTKDYNSLKNG.....MSYNK..VKELLGEPDDISQAVSSDKEEL
   8 VKTISNFTFA.....RELGLSQKEYQQLQKG.....MSYED..AKKILTEPDNYSQASSSDHQTL
   9 VKTISNFTFA.....RELGLSQKEYQQLQKR.....MSYED..VKKILTEPDNYSQASSSDHQTL
  10 VRSISNFKFI.....RDANITTKDYNSLKNG.....MSYNK..VKELLGEPDDISQAVSSDKEEL
  11 ARSISNFSFS.....REAKIGKEDYDELKIG.....ESYKK..VVEKLGEPDVLSQSMSSDKEEM
  12 GKAQAGLSMG.....K-ADVNLIKYAKITTG.....MDYSK..VEEILGDGKLMSISKTNGSTKS
  13 GKAQAGLSMG.....K-ADVNLIKYAKITTG.....MDYSK..VEEILGDGKLMSISKTNGSTKS
  14 GKAQAGLSMG.....K-ADVNLIKYAKITTG.....MDYSK..VEEILGDGKLMSISKTNGSTKS
  15 GKAQAGLSMG.....K-ADVNLIKYTKIRTG.....MDYSK..VKEILGDGKLMSISKTNGSTKS
  16 GKAQADLSMG.....K-ADVNLIKYAKITTG.....MDYSK..VEEILGDGKLMSISKTNGSTKS
  17 AKAQAGLSRK.....R-ADVNMEKYNKIQTG.....MDYNK..VKEILGDGELMSISEVGGSNTS
  18 AKAQAGLSRE.....K-ADVNMEKYNTIQTG.....MDYNK..IKEILGAGELMSISEVGGSNTS
  19 TKDITGFKWGk....RDEKLDLAAFNSIQDG.....ASYDD..IVKKYGEPDSLNESLLLGTKTV
  20 TKDITGFKWGk....RDEKLDLAAFNSIQDG.....ATYDD..IVKKYGEPDSLNESLLLGTKTV
  21 VRSISNFKFI.....RDANITTKDYNSLKNG.....MSYNK..VKELLGEPDDISQAVSSDKEEL
  22 SKEITGFKWGk....RDEKLTLGEFNNIADG.....STYQS..LVDKYGEPDGLHEANVAGTKIT
  23 VRSISNFKFI.....RDANITTKDYNSLKNX.....XSYNK..VKELLGEPDDISQA--------
  24 SKIEIGLE-K.....INANISRVKYKKISRG.....MSYEK..VKNLVGKGELLSETNLMGSNSK
  25 AKQISGLVVN.....RSKQITPKDYKSLKKG.....MTQEE..VEAIVGKPNGYSESDYSNSEVV
  26 AKQISGLVVN.....RSKQITPKDYKSLKKG.....MTQEE..VEAIVGKPNGYSESDYSNSEVV
  27 SKSVSGLKVA.....KHDKVTADQVNNIATD.....GSYSEeqARKDLGDPTGITSTNINGEKND
  28 SKSVSGLKVA.....KHDKVTADQVNNIATD.....GSYSEeqARKDLGDPTGITSTNINGEKND
  29 TKEQYKLN-D.....NFSVLSSEKISSLKKG.....MSYDE..AKNILGEGILRSEEKGIKVFTW
  30 TKEQYKLN-D.....KFSILSNKKINSLKKG.....MSYNE..VKNILGEGILRSEEK----ETQ
  31 AKAQAGLSRE.....R-ADVNAEKYNRIQTG.....MDYNK..VKEILGDGE-------------
  32 SPEAPNTSGD.....NETVITKENYDKVKNG.....MSYEE..VVKIIGSEGEIVTETGEKGDDM
  33 ----------.....GCSKLTMENYSKIKTG.....IGYTE..VVKILGKPDNCSEA--------
  34 ------LPLA.....GCNKLTPENYDKLRMG.....MHYAE..VKSILGEPTRCSD---------
  35 ---------L.....GCSKLTQENYAKLKMG.....LGYGE..VVTILGKPDSCSEA--------
  36 ----------.....GCSKLTTENYEKIKMG.....MDYGE..VAGILGKPDSCSEA--------
  37 AIVLSAFLFG.....CFSKINQENYAKIENG.....MTMEQ..VKDILGEPTESQTAGIGSLSGT
  38 ----------.....--SKVTVENYDKIRVG.....MTYDE..VKQLLGAPNRCSDV--------
  39 ----------.....----------------.....-----..----------------------
  40 ----------.....---------YEDLKNG.....TSYDN..AVKILGVPDVYSIAVSSDATMT
  41 ----------.....---------YEDLKNG.....TSYDN..AVKTLGVPDVYSIAVSSDATMT
  42 ----------.....---------YEDLKNG.....TSYDN..AVQTLGVPDVYSIAVSSDATMT
  43 ----------a....CENKVTRENYDKLAIG.....MEYSK..VVELLGEPENCQSV--------
  44 ----------.....NKELVSQEKYKQLKLD.....MSYED..VKKIMGSPGKVKKFPGQPSTET
  45 ----------.....-----YMEEYDKIEVG.....ISANK..VKELIGEPSDIEKYKSYSLYRY
  46 -------TG-.....-------------AGG.....EKYED..VVAKFGEPDNKAESQAGDIKMI
  47 -------TG-.....-------------AGG.....EKYED..VVAKFGEPDNKAESQAGDIKMI
  48 TKIEENGLRHq14nqQSHPVSLDMFESIKIG.....MTADE..VTEIVGTSPR------------
  49 ----------.....---KITVADVDTIKTGdp8ggDKYED..LVAKYGEPDIKSDSTSKNVKTY


            180        190        200      
             |          |          |      
   1 QTVWSSGIKTKSSSA.TIELYF.ENGLLKNKTQKDLE
   2 QAIWVSGLKTDTSGA.NISLVF.ENNQLTEMSQVGLE
   3 QAIWVSGLKTDTSGA.NISLVF.ENNQLTEMSQVGLE
   4 QAIWVSGLKTDTSGA.NISLVF.ENNQLTEMSQVGLE
   5 QAIWVSGLKTDTSGA.NISLVF.ENNQLTEMSQVGLE
   6 QAAWISGIQSSDSDP.GINLTF.ENDKLTNKQQHGLK
   7 QAAWISGIQSSDSDP.GINLTF.ENDKLTNKQQHGLK
   8 QAIWVSGLKTDTSGA.NISLVF.ENNQLTEMSQVGLE
   9 QAIWVSGLKTDTSGA.NISLVF.ENNQLTEMSQVGLE
  10 QAAWISGIQSSDSDP.GINLTF.ENDKLTNKQQHGLK
  11 QTVWSSGIKTKSSSA.TIELYF.ENGLLKNKTQKDLE
  12 IYLWA-----NPNGT.NMNVTF.QNGKVTAKNRLGL-
  13 IYLWA-----NPNGT.NMNVTF.QNGKVTAKNRLGL-
  14 IYLWA-----NPNGT.NMNVTF.QNGKVTAKNRLGL-
  15 IYLWA-----NPNGT.NMNVTF.QNGKVTTKNRLGL-
  16 IYLWA-----NPNGT.NMNVTF.QNGKVTAKNRLGL-
  17 IYSWV-----NSNGT.NINVTF.QDGKSAAKAQFGLK
  18 IYSWV-----NSNGT.NMNVTF.QDGKSAAKAQFGLK
  19 TALWYTGIKGKGAGA.NASLTF.ENGALTSKTQTDLK
  20 TGLWYTGIKGKADGA.FASLTF.ENGALTSKTQTDLK
  21 QAAWISGIQSSDSDP.GINLTF.ENDKLTNKQQHGLK
  22 NAVWLTGIK-GDDGA.SATFSF.ENDKLSSKTQTKLK
  23 ---------------.------.--------------
  24 MYQWV-----NSDGS.SMNITF.TNGIVDYKTEKKLK
  25 LWLYTSGLK-SDDQA.NFYVTF.QKNKLVAKKAQN--
  26 LWLYTSGLK-SDDQA.NFYVTF.QKNKLVAKKAQN--
  27 TLIWMKNLD-GDLGA.TVTVSF.SNGSAISKSSSGLK
  28 TLIWMKNLD-GDLGA.TVTVSF.SNGNAISKSSSGLK
  29 F---------DNNSK.YLNCTF.KNDKLTI-------
  30 VYSWF-----NNDSS.YINCTF.KNDKL---------
  31 ---------------.------.--------------
  32 YGIAVLYENKGSSLS.NATFIF.LGDKLQSKSQYGLE
  33 --LFVRNCVWGNEQK.NITVSF.VGDKAILFSSKNIK
  34 -LLAVKACTWGDDAR.YINVNF.VADQAVLLNSSNLR
  35 --LFAKSCVWGDEQK.NITVNF.AGDRVVLFTSTNIR
  36 --LFAKSCIWGNEQK.NITVNF.VGDKTILFTSKNIR
  37 NAIW------KSDSV.TIKLTF.VNSKVQLK------
  38 --MTVKSCTWGDEKR.HVQVSF.VADQVVLFSSENLR
  39 ---------------.------.--------------
  40 QALWSSNLVTKKGKTgSLTLNF.KNGTLENKSQENL-
  41 QALWSSNLVTKKGKTgSLTLNF.KNGTLENKSQENL-
  42 QALWSSNLVTKKGKTgSLTLNF.KNGTLENKSQENL-
  43 --VSVKSCVWGKTPK.TISVQF.VGEKILFYSNTG--
  44 TYVWK----QKNSSY.RILVTL.KDGKV---------
  45 G--------GWDSKG.EMTVYFdKNGTVTKKEQNGLR
  46 IASWTKNVN-GDLGA.NFNVTF.T-------------
  47 IASWTKNVN-GDLGA.NFNVTF.T-------------
  48 ---------------.------.--------------
  49 TASWSKNAK-GGTGA.NFTVSF.I-------------