a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0319 TRM112, Saccharomyces cerevisiae, 135 res
- gi|94374063|ref|XP_991830.1|_1:122 PREDICTED: similar to UPF0315 protein [Mus musculus]
- gi|82896254|ref|XP_910906.1| PREDICTED: similar to UPF0315 protein [Mus musculus]
- gi|82896077|ref|XP_897794.1| PREDICTED: similar to UPF0315 protein [Mus musculus]
- gi|12833034|dbj|BAB22361.1| unnamed protein product [Mus musculus]
- gi|47606210|sp|Q9DCG9|U315_MOUSE UPF0315 protein [Taxonomy]
- gi|27661288|ref|XP_215167.1|_1:122 PREDICTED: similar to RIKEN cDNA 0610038D11 [Rattus norvegicus]
- gi|61825899|ref|XP_584517.1|_1:122 PREDICTED: similar to UPF0315 protein isoform 1 [Bos taurus]
- gi|86438346|gb|AAI12714.1| Similar to UPF0315 protein [Bos taurus]
- gi|16877890|gb|AAH17172.1|_1:122 Hypothetical protein HSPC152 [Homo sapiens]
- gi|75991684|gb|AAI05295.1| Hypothetical protein LOC51504 [Homo sapiens]
- gi|7705477|ref|NP_057488.1| hypothetical protein LOC51504 [Homo sapiens]
- gi|8980669|gb|AAF82266.1| HSPC170 protein [Homo sapiens]
- gi|6841526|gb|AAF29116.1| HSPC152 [Homo sapiens]
- gi|6523795|gb|AAF14857.1| adrenal gland protein AD-001 [Homo sapiens]
- gi|47606219|sp|Q9UI30|U315_HUMAN UPF0315 protein AD-001 [Taxonomy]
- gi|57099691|ref|XP_533242.1|_1:122 PREDICTED: similar to UPF0315 protein [Canis familiaris]
- gi|20809962|gb|AAH29482.1|_1:122 Hypothetical protein HSPC152 [Homo sapiens]
- gi|61098120|ref|NP_080582.2|_1:122 hypothetical protein LOC67674 [Mus musculus]
- gi|56789040|gb|AAH87959.1| Hypothetical protein LOC67674 [Mus musculus]
- gi|6324374|ref|NP_014444.1|_1:134 Subunit of an adoMet-dependent tRNA methyltransferase (MTase) complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; putative zinc binding subunit of other MTase-related proteins; Trm112p [Saccharomyces cerevisiae]
- gi|1302556|emb|CAA96327.1| unnamed protein product [Saccharomyces cerevisiae]
- gi|1730682|sp|P53738|YN8Q_YEAST UPF0315 protein YNR046w [Taxonomy]
- gi|94376467|ref|XP_983891.1|_1:122 PREDICTED: similar to UPF0315 protein [Mus musculus]
- gi|82898045|ref|XP_910512.1| PREDICTED: similar to UPF0315 protein [Mus musculus]
- gi|94374925|ref|XP_985026.1| PREDICTED: similar to UPF0315 protein [Mus musculus]
- gi|12833869|dbj|BAB22695.1|_1:122 unnamed protein product [Mus musculus]
- gi|55636315|ref|XP_522051.1|_1:122 PREDICTED: similar to UPF0315 protein (AD-001) (HSPC152/HSPC170) [Pan troglodytes]
- gi|16740612|gb|AAH16191.1|_1:120 0610038D11Rik protein [Mus musculus]
- gi|44982857|gb|AAS52087.1|_1:133 ADR166Wp [Ashbya gossypii ATCC 10895]
- gi|45188040|ref|NP_984263.1| ADR166Wp [Eremothecium gossypii]
- gi|51970254|dbj|BAD43819.1|_1:124 hypothetical protein [Arabidopsis thaliana]
- gi|51970200|dbj|BAD43792.1| hypothetical protein [Arabidopsis thaliana]
- gi|91079885|ref|XP_967890.1|_1:124 PREDICTED: similar to UPF0315 protein [Tribolium castaneum]
- gi|76657806|ref|XP_885500.1|_1:125 PREDICTED: similar to UPF0315 protein isoform 3 [Bos taurus]
- gi|50416141|ref|XP_457528.1|_1:127 hypothetical protein DEHA0B13497g [Debaryomyces hansenii CBS767]
- gi|49653193|emb|CAG85537.1| unnamed protein product [Debaryomyces hansenii CBS767]
- gi|50306129|ref|XP_453026.1|_1:130 unnamed protein product [Kluyveromyces lactis]
- gi|49642159|emb|CAH01877.1| unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
- gi|6967027|emb|CAB72434.1| hypothetical protein [Kluyveromyces lactis]
- gi|55596061|ref|XP_525713.1|_1:132 PREDICTED: hypothetical protein XP_525713 [Pan troglodytes]
- gi|70991349|ref|XP_750523.1|_1:124 hypothetical protein Afu6g06330 [Aspergillus fumigatus Af293]
- gi|66848156|gb|EAL88485.1| conserved hypothetical protein [Aspergillus fumigatus Af293]
- gi|94468700|gb|ABF18199.1|_1:122 hypothetical conserved protein [Aedes aegypti]
- gi|50285803|ref|XP_445330.1|_1:132 unnamed protein product [Candida glabrata]
- gi|49524634|emb|CAG58236.1| unnamed protein product [Candida glabrata CBS138]
- gi|71024417|ref|XP_762438.1|_81:207 hypothetical protein UM06291.1 [Ustilago maydis 521]
- gi|46097687|gb|EAK82920.1| hypothetical protein UM06291.1 [Ustilago maydis 521]
- gi|21299129|gb|EAA11274.1|_1:122 ENSANGP00000002571 [Anopheles gambiae str. PEST]
- gi|31247998|ref|XP_316602.1| ENSANGP00000002571 [Anopheles gambiae str. PEST]
- gi|88955003|ref|XP_945646.1|_1:132 PREDICTED: similar to UPF0315 protein AD-001 [Homo sapiens]
- gi|41190515|ref|XP_372921.1| PREDICTED: similar to UPF0315 protein AD-001 [Homo sapiens]
- gi|15218237|ref|NP_177943.1|_1:124 unknown protein [Arabidopsis thaliana]
- gi|12324252|gb|AAG52099.1| unknown protein; 53758-53384 [Arabidopsis thaliana]
- gi|47606209|sp|Q9C9R3|U316_ARATH UPF0315 protein At1g78190 [Taxonomy]
- gi|18395095|ref|NP_564163.1|_1:124 unknown protein [Arabidopsis thaliana]
- gi|30102552|gb|AAP21194.1| At1g22270 [Arabidopsis thaliana]
- gi|21537034|gb|AAM61375.1| unknown [Arabidopsis thaliana]
- gi|51970692|dbj|BAD44038.1| hypothetical protein [Arabidopsis thaliana]
- gi|51970600|dbj|BAD43992.1| hypothetical protein [Arabidopsis thaliana]
- gi|51969790|dbj|BAD43587.1| hypothetical protein [Arabidopsis thaliana]
- gi|51969466|dbj|BAD43425.1| hypothetical protein [Arabidopsis thaliana]
- gi|51969448|dbj|BAD43416.1| hypothetical protein [Arabidopsis thaliana]
- gi|51968428|dbj|BAD42906.1| hypothetical protein [Arabidopsis thaliana]
- gi|47606185|sp|Q8LFJ5|U315_ARATH UPF0315 protein At1g22270 [Taxonomy]
- gi|9392687|gb|AAF87264.1|_1:124 EST gb|F14399 comes from this gene. [Arabidopsis thaliana]
- gi|47225269|emb|CAG09769.1|_1:122 unnamed protein product [Tetraodon nigroviridis]
- gi|68483093|ref|XP_714482.1|_1:127 hypothetical protein CaO19.11069 [Candida albicans SC5314]
- gi|68483194|ref|XP_714432.1| hypothetical protein CaO19.3585 [Candida albicans SC5314]
- gi|46436052|gb|EAK95421.1| hypothetical protein CaO19.11069 [Candida albicans SC5314]
- gi|46435995|gb|EAK95365.1| hypothetical protein CaO19.3585 [Candida albicans SC5314]
- gi|72006149|ref|XP_784899.1|_1:123 PREDICTED: similar to UPF0315 protein [Strongylocentrotus purpuratus]
- gi|914880|emb|CAA90460.1|_1:126 SPAC31A2.02 [Schizosaccharomyces pombe]
- gi|19113826|ref|NP_592914.1| hypothetical protein SPAC31A2.02 [Schizosaccharomyces pombe 972h-]
- gi|1175395|sp|Q09723|YA42_SCHPO Hypothetical UPF0315 protein C31A2.02 in chromosome I [Taxonomy]
- gi|2130413|pir||S58099 conserved hypothetical protein SPAC31A2.02 - fission yeast (Schizosaccharomyces pombe) [Taxonomy]
- gi|83767102|dbj|BAE57241.1|_1:125 unnamed protein product [Aspergillus oryzae]
- gi|50553917|ref|XP_504367.1|_1:127 hypothetical protein [Yarrowia lipolytica]
- gi|49650236|emb|CAG79966.1| unnamed protein product [Yarrowia lipolytica CLIB122]
- gi|66472212|ref|NP_001018588.1|_1:121 hypothetical protein LOC553790 [Danio rerio]
- gi|68402273|ref|XP_684258.1| PREDICTED: similar to UPF0315 protein [Danio rerio]
- gi|63100714|gb|AAH95351.1| Hypothetical protein LOC553790 [Danio rerio]
- gi|62859907|ref|NP_001016673.1|_1:122 hypothetical protein LOC549427 [Xenopus tropicalis]
- gi|90302146|gb|EAS31777.1|_1:125 hypothetical protein CIMG_07256 [Coccidioides immitis RS]
- gi|21358217|ref|NP_649293.1|_1:124 CG12975-PA [Drosophila melanogaster]
- gi|17946242|gb|AAL49161.1| RE57810p [Drosophila melanogaster]
- gi|47606220|sp|Q9VP65|U315_DROME UPF0315 protein CG12975 [Taxonomy]
- gi|7296402|gb|AAF51690.1| CG12975-PA [Drosophila melanogaster]
- gi|89292715|gb|EAR90703.1|_28:151 hypothetical protein TTHERM_00705190 [Tetrahymena thermophila SB210]
- gi|54641056|gb|EAL29807.1|_1:124 GA11949-PA [Drosophila pseudoobscura]
- gi|85103652|ref|XP_961567.1|_1:126 hypothetical protein [Neurospora crassa OR74A]
- gi|32412428|ref|XP_326694.1| hypothetical protein [Neurospora crassa OR74A]
- gi|18376308|emb|CAD21420.1| conserved hypothetical protein [Neurospora crassa]
- gi|47606194|sp|Q8X0S4|U315_NEUCR Hypothetical UPF0315 protein 18F11.160 [Taxonomy]
- gi|28923114|gb|EAA32331.1| hypothetical protein [Neurospora crassa]
- gi|92897581|gb|ABE93747.1|_1:122 Protein of unknown function DUF343 [Medicago truncatula]
- gi|46126125|ref|XP_387616.1|_1:126 hypothetical protein FG07440.1 [Gibberella zeae PH-1]
- gi|42554614|gb|EAA77457.1| hypothetical protein FG07440.1 [Gibberella zeae PH-1]
- gi|57225701|gb|AAW42162.1|_3:122 conserved hypothetical protein [Cryptococcus neoformans var. neoformans JEC21]
- gi|58264626|ref|XP_569469.1| hypothetical protein [Cryptococcus neoformans var. neoformans JEC21]
- gi|50259041|gb|EAL21720.1| hypothetical protein CNBC5840 [Cryptococcus neoformans var. neoformans B-3501A]
- gi|66808727|ref|XP_638086.1|_1:122 hypothetical protein DDB0186528 [Dictyostelium discoideum]
- gi|60466530|gb|EAL64582.1| hypothetical protein DDBDRAFT_0186528 [Dictyostelium discoideum AX4]
- gi|50939327|ref|XP_479191.1|_1:131 unknown protein [Oryza sativa (japonica cultivar-group)]
- gi|22535669|dbj|BAC10843.1| unknown protein [Oryza sativa (japonica cultivar-group)]
- gi|30725332|gb|AAP37688.1|_2:117 At1g78190 [Arabidopsis thaliana]
- gi|56756671|gb|AAW26508.1|_1:123 SJCHGC04493 protein [Schistosoma japonicum]
- gi|67471633|ref|XP_651756.1|_1:123 conserved hypothetical protein [Entamoeba histolytica HM-1:IMSS]
- gi|67477710|ref|XP_654297.1| conserved hypothetical protein [Entamoeba histolytica HM-1:IMSS]
- gi|56471332|gb|EAL48911.1| conserved hypothetical protein [Entamoeba histolytica HM-1:IMSS]
- gi|56468531|gb|EAL46370.1| conserved hypothetical protein [Entamoeba histolytica HM-1:IMSS]
- gi|84997407|ref|XP_953425.1|_1:114 hypothetical protein TA09955 [Theileria annulata strain Ankara]
- gi|65304421|emb|CAI76800.1| hypothetical protein, conserved [Theileria annulata]
- gi|71029570|ref|XP_764428.1|_1:119 hypothetical protein TP04_0926 [Theileria parva strain Muguga]
- gi|68351382|gb|EAN32145.1| hypothetical protein, conserved [Theileria parva]
- gi|23497136|gb|AAN36684.1|_1:129 hypothetical protein, conserved [Plasmodium falciparum 3D7]
- gi|23509293|ref|NP_701960.1| hypothetical protein PF14_0072 [Plasmodium falciparum 3D7]
- gi|62175639|gb|AAX69771.1|_1:124 hypothetical protein, conserved [Trypanosoma brucei]
- gi|70802641|gb|AAZ12546.1| hypothetical protein, conserved [Trypanosoma brucei]
- gi|71750171|ref|XP_823991.1| hypothetical protein Tb927.7.4820 [Trypanosoma brucei TREU927]
- gi|17531497|ref|NP_497021.1|_1:121 C04H5.1 [Caenorhabditis elegans]
- gi|3873940|emb|CAB03840.1| Hypothetical protein C04H5.1 [Caenorhabditis elegans]
- gi|47606061|sp|O45241|U315_CAEEL Hypothetical UPF0315 protein C04H5.1 [Taxonomy]
- gi|71654515|ref|XP_815875.1|_1:124 hypothetical protein [Trypanosoma cruzi strain CL Brener]
- gi|70880964|gb|EAN94024.1| hypothetical protein, conserved [Trypanosoma cruzi]
- gi|18044448|gb|AAH19418.1|_1:99 0610038D11Rik protein [Mus musculus]
- gi|71077473|ref|XP_771250.1|_1:122 hypothetical protein GLP_447_64404_64015 [Giardia lamblia ATCC 50803]
- gi|29249569|gb|EAA41078.1| GLP_447_64404_64015 [Giardia lamblia ATCC 50803]
- gi|68124078|emb|CAJ02060.1|_1:137 hypothetical protein, conserved [Leishmania major]
- gi|89268726|emb|CAJ83344.1|_2:79 novel protein [Xenopus tropicalis]
- gi|47192409|emb|CAF92260.1|_1:89 unnamed protein product [Tetraodon nigroviridis]
- gi|55630720|ref|XP_528137.1|_2:79 PREDICTED: similar to RIKEN cDNA 0610038D11 [Pan troglodytes]
- gi|89028705|ref|XP_942798.1|_3:76 PREDICTED: similar to UPF0315 protein [Homo sapiens]
- gi|89028114|ref|XP_373253.2| PREDICTED: similar to UPF0315 protein [Homo sapiens]
- gi|55624178|ref|XP_526879.1|_9:49 PREDICTED: similar to hypothetical protein [Pan troglodytes]
- gi|88988366|ref|XP_943001.1|_3:43 PREDICTED: similar to UPF0315 protein [Homo sapiens]
- gi|76657808|ref|XP_885527.1|_2:39 PREDICTED: similar to UPF0315 protein isoform 4 [Bos taurus]
- gi|82595085|ref|XP_725699.1|_6:84 hypothetical protein PY05264 [Plasmodium yoelii yoelii str. 17XNL]
- gi|23480803|gb|EAA17264.1| hypothetical protein [Plasmodium yoelii yoelii]
- gi|19173444|ref|NP_597247.1|_1:115 hypothetical protein ECU08_1170 [Encephalitozoon cuniculi GB-M1]
- gi|19171033|emb|CAD26423.1| hypothetical protein [Encephalitozoon cuniculi GB-M1]
- gi|71078172|ref|XP_771596.1|_10:119 hypothetical protein GLP_422_19327_19698 [Giardia lamblia ATCC 50803]
- gi|29249922|gb|EAA41424.1| GLP_422_19327_19698 [Giardia lamblia ATCC 50803]
- gi|94420045|ref|XP_001005141.1|_10:69 PREDICTED: similar to UPF0315 protein [Mus musculus]
- gi|76802014|ref|YP_327022.1|_29:56 hypothetical protein NP2744A [Natronomonas pharaonis DSM 2160]
- gi|76557879|emb|CAI49463.1| conserved hypothetical protein [Natronomonas pharaonis DSM 2160]
- gi|88950948|ref|ZP_01153522.1|_29:56 Protein of unknown function DUF343 [Methanosaeta thermophila PT]
- gi|88930147|gb|EAR49095.1| Protein of unknown function DUF343 [Methanosaeta thermophila PT]
- gi|91773261|ref|YP_565953.1|_29:56 protein of unknown function DUF343 [Methanococcoides burtonii DSM 6242]
- gi|91712276|gb|ABE52203.1| protein of unknown function DUF343 [Methanococcoides burtonii DSM 6242]
- gi|10580638|gb|AAG19488.1|_29:56 Vng1090h [Halobacterium sp. NRC-1]
- gi|15790184|ref|NP_280008.1| hypothetical protein VNG1090H [Halobacterium sp. NRC-1]
- gi|82595087|ref|XP_725700.1|_2:26 hypothetical protein PY05265 [Plasmodium yoelii yoelii str. 17XNL]
- gi|23480804|gb|EAA17265.1| hypothetical protein [Plasmodium yoelii yoelii]
- gi|19917314|gb|AAM06651.1|_29:56 conserved hypothetical protein [Methanosarcina acetivorans C2A]
- gi|20092096|ref|NP_618171.1| hypothetical protein MA3281 [Methanosarcina acetivorans C2A]
- gi|55230803|gb|AAV46222.1|_29:56 unknown [Haloarcula marismortui ATCC 43049]
- gi|55378078|ref|YP_135928.1| hypothetical protein rrnAC1284 [Haloarcula marismortui ATCC 43049]
- gi|5104154|dbj|BAA79470.1|_66:92 136aa long hypothetical protein [Aeropyrum pernix K1]
- gi|14600764|ref|NP_147285.1| hypothetical protein APE0505 [Aeropyrum pernix K1]
- gi|88603566|ref|YP_503744.1|_28:54 protein of unknown function DUF343 [Methanospirillum hungatei JF-1]
- gi|88189028|gb|ABD42025.1| protein of unknown function DUF343 [Methanospirillum hungatei JF-1]
- gi|72398117|gb|AAZ72390.1|_25:51 conserved hypothetical protein [Methanosarcina barkeri str. fusaro]
- gi|73670955|ref|YP_306970.1| hypothetical protein Mbar_A3520 [Methanosarcina barkeri str. fusaro]

              10        20        30        40                  50     
              |         |         |         |                   |     
   1 MKFLTTNFLKCSVKACDTSNDNFPLQYDGSKCQLVQDESI.....EFNPEF.....LLNIVDRVD
   2 MKLLTHNLLSSHVRGVGTRGFPLRLQATEVR-----INPV.....EFNPEF.....VARMIPKVE
   3 MKLLTHNLLSSHVRGVGTRGFPLRLQATEVR-----INPV.....EFNPDF.....VARMIPKVE
   4 MRLLTHNLLSSHVRGVGPRGFPLRLQATEVR-----INPV.....EFNPDF.....IVRMIPKVE
   5 MKLLTHNLLSSHVRGVGSRGFPLRLQATEVR-----ICPV.....EFNPNF.....VARMIPKVE
   6 MKLLTHNLLSSHVRGVGPRGFPLRLQATEVR-----INPV.....EFNPDF.....VARMIPKVE
   7 MKLLTHNLLSSHVRGVGSRGFPLRLQATEVR-----ICPV.....EFNPNF.....VARMIPKVE
   8 MKLLTHNLLSSHVRGVGTRGFPLRLQATEVR-----INPV.....EFNPEF.....VARMIPKVE
   9 MKFLTTNFLKCSVKACDTSNDNFPLQYDGSKCQLVQDESI.....EFNPEF.....LLNIVDRVD
  10 MKLLIHNLLSSHVRGVGTRGFPLRLQATEVR-----INPV.....EFNPEF.....MARMIPKVE
  11 MKLLTHNLLSSHVRGVGTRGFPLRLQATEVR-----INPV.....EFNPEF.....VARMIPKVE
  12 MKLLTHNLLSSHVRGVGSRGFPLRLQATEVR-----ICPV.....EFNPNF.....VARMIPKVE
  13 MKLLTHNLLSSHVRGVGTRGFPLRLQATEVR-----INPV.....EFNPEF.....VARMIPKVE
  14 MKFLTTNFLKCSVPACDGSNDNFPLRYIGDKCQLQQDSSI.....EFNPDF.....LLRILDRVQ
  15 MRLITHNMLSCNIKGVTSG------FPLRIEAGSVIEKEV.....DFNPDF.....IRHMFAKIE
  16 MKLLTHNMLTSKCMKVVTVGYPLGINASDVR-----VSEV.....DFNPDF.....VAKIIPKVD
  17 MRLLTHNLLSSHVRGVGPRGFPLRLQATEVR-----INPV.....EFNPDF.....IVRMIPKVE
  18 MKFLTTNFVKCAIKSCDSSADSFPLQYADCQ---LAQEEQ.....DYNPEF.....ISHILERLD
  19 MKFLTTNFLKCSVKGCDNSNLNFPLRYVRENCQLEQDESI.....EFNPEF.....LLRIIDRVD
  20 MKLLTHNLLSSHVRGVGSRGFPLCLQATEVRICPVEFNPQltwhhTWHVSY.....VVHMIPKVE
  21 MKLVTANFLTCAVKGCKTSSASFPLHFQDAE---LELEEL.....DFQPEF.....IRNIIPRVD
  22 MKLLTYNFLTSKCIRGVKVGYPLKLNIVEKK-----VVSS.....DFNSEF.....ITRMIPRLD
  23 MKFLTTNFLKCSVKGCDTSNDNFPLAYGECQ--LVQDESI.....EFNPEF.....LINILDRVD
  24 MRLLTHNLLACHAKACATTSNNFPLILKDVQ---LELIEA.....EPNEIF.....IKGFLPKLD
  25 MKLLTYNFLTSKCIRGVKVGYPLKLNIVEKK-----EVNA.....DFNSEF.....ITRMLPRLE
  26 MKLLTHNLLSSHVRGMGSRGFPLCLQATEVR-----ICPV.....EFNPQFm10syVVHMIPKVE
  27 MRLIVHNMLSCNIKGVVNK------FPLRIEAEKVTVKEV.....DFNPDF.....LRYMFAKID
  28 MRLITHNMLSCNIKGVTSG-F-----PLRIEAGNVIEKEV.....DFNPDF.....IRHMFAKIE
  29 MRLITHNMLSCNIKGVTSG-F-----PLRIEAGNVIEKEV.....DFNPDF.....IRHMFAKIE
  30 MKLLTHNMLTSHVKGVTQGYP-LLI-----KATEVKVNEV.....DFNPQF.....VSRMIPKLE
  31 MKFLTTNFVKCAVKSCQSSLDSFPLKYEECQ---LVQEEQ.....DYNPEF.....IVHMLDRLD
  32 MKLLTHNMLTSHVKGVKNGY-P-----LRIEPENTRILEV.....EFNPDF.....IARMIPRID
  33 MKLLTANFLNCSNKKCTSSPEAFPLDVVDAK---LAIQQL.....ELKPEF.....LIGIMPRID
  34 MKLITANFLTCAVKGCKASPASFPLHFRDAE---LELQEL.....DFQPDF.....IRNIVPRID
  35 MKFLTSNFVQCASKQCVSSGNAFPLTFSALE---MVQQEA.....EFDPEF.....LVSMLERID
  36 MKLLTHNMLTSHVKGVTKG-YPLIIKATE-----VKVNEL.....DFNAQF.....VSRMIPKLE
  37 MKLLTHNMLRSHVSGVTR-GFPLLIRAEE-----VKLSAV.....DFNQDF.....VTRMIPKLE
  38 MKVLTANFVTCAVKSCKASPTSFPLHFHNAE---LEQQEI.....EFSPQF.....LYNILPRID
  39 MKLSTYNFLTSVAIKGVKVGFPLKLTINKKE-----VVES.....EFNPTF.....VERILPKLD
  40 MRLLSHNLLQCNVKNCKSNNFPLKIQVDKSN-----IINC.....EFRKEP.....LVKLIPKLD
  41 MKLSTYNFLTSMAIKGVKVGFPLKLTISKKE-----LVET.....EFNPTF.....VERLLPKLD
  42 MKVMTLNFLTCAVKNCKSSNDSFPLHPKEAE---LAKDDI.....EINPQL.....LINVLPRID
  43 MRLLTHNMLSSNIKGVVNG------FPLRIEAEKVVEKNV.....EMNGDF.....LKKMFEKIE
  44 MKVLSLNFLTCAAKACKSSKDSYPLHPKDAE---LVQDDI.....ELNPDM.....IINVLPRLD
  45 -RLITHNMLACHVKNCTKDNFPLVFS--EVE---LVERPA.....PINPDF.....IKRFLPKLD
  46 MKILTHNMMACTKKQCMGKGFPLKV-----ESTEQIVLEQ.....EFNYEF.....TKNIYPKLD
  47 MRLLTHNMLASNARGAVTG-YPLKLQVVK-----WSTKEA.....EPNPEF.....LRGMLPKID
  48 --------LSCNIKGVVNK------FPLRIEAEKVTVKEV.....DFNPDF.....LRYMFAKID
  49 MKLFLHNILTSRVLKSVKVGYPLKLKAKALK-----VSTV.....DYDPSS.....VARLIPKVE
  50 MKLFTHNLLICTKRQCGINSFPLKITAEKVE---KVTTPL.....DADFLI.....SLVESERLN
  51 MRLLTHNMLMCNKNNCTQGYPLKIE--INQEPDSYKVEPQ.....PVNPEF.....VKKMLSRMD
  52 MRLLTHNMLMCNKSNCTKGYPLKIE-L-NEEPDSYKVEAQ.....PVNPEF.....IKKMLSRMD
  53 MRLLTHNFLKCNETQCT-GGYPLTIKLDMDSQENIKIIDQ.....DINVEF.....VKNVLSKVD
  54 MRLLTHNFLCCIQCQSFP---------LQLQATELEVLAS.....EYNPEF.....IRTMLARMD
  55 MKLFVHNFMSSRFLKNVTVGYPLNLVVKQ-----FVEKDI.....EFDRDN.....TIVMLDRIQ
  56 MRLLTHNFLCCIECQSFP---------LQLRDVEVEVLPS.....EFNPAF.....IRLMLARMD
  57 MKLLTHNLLSSHVRGVGTRGFPLRLQATEVR-----INPV.....EFNPEF.....VARMIPKVE
  58 MHLFLLSTLTCPRKSCCTANAGFTVDVTEQ----AEDDAP.....EYNIDI.....VRKLASRMD
  59 MRLLTHNFLACLKCDTYPL---------LVTAAEMEEIPV.....EYDAEF.....TRRMLARVD
  60 ----------------------------------------.....------.....----IPKLE
  61 MKLLTHNMLTSHVKGVTQGYP-LLI-----KATEVKVNEV.....DFNPQF.....VSRMIPKLE
  62 ----------------------------------------.....------.....----LPMVE
  63 ----------------------------------------.....------.....--------E
  64 ----------------------------------------.....------.....---------
  65 ----------------------------------------.....------.....---------
  66 ----------------------------------------.....------.....---------
  67 -----------------TGGYPLIIKLNEDVEGNVNIIEQ.....EMNPEF.....IKNVLSKVD
  68 MKPFLLGLLKCKRCSFMTKL---I---LECEKAESNDVDT.....DDVKIF.....NKHMFTENG
  69 ---------ACPHCR-----APFILSCTALQRDEFTDLH-.....--KRAK.....VSAILTRAC
  70 -----------------------------LQATEICINSV.....DFNPDF.....LAQMIHKVK
  71 ----------------------------------------.....------.....---------
  72 ----------------------------------------.....------.....---------
  73 ----------------------------------------.....------.....---------
  74 ----------------------------------------.....------.....---------
  75 ----------------------------------------.....------.....---------
  76 ----------------------------------------.....------.....---------
  77 ----------------------------------------.....------.....---------
  78 ----------------------------------------.....------.....---------
  79 ----------------------------------------.....------.....---------
  80 ----------------------------------------.....------.....---------


         60        70             80               90        100       
         |         |              |                |          |       
   1 WPAVLTVAAELGNNA..LPPTKPS...FPSSI..QE.....LTDDDM.AILNDLHTLLLQTSIAE
   2 WAALVQAADTLNLAE..VP-----...--KEP..TE.....GYEHDE.TFLRKMHHVLLEVDVLE
   3 WAALVQAADTLNLAE..VP-----...--KEP..TE.....GYEHDE.TFLRKMHHVLLEVDVLE
   4 WAALLEAADHLHLIQ..VP-----...--KEP..IQ.....GYEHNE.EFLRKMHHVLLEVEVLE
   5 WSAFLEAADNLRLIQ..VP-----...--KGP..VE.....GYEENE.EFLRTMHHLLLEVEVIE
   6 WAALLEAAETLHLVE..VP-----...--KGP..IE.....GYEHDE.KFLRQMHHVLLEVDVLE
   7 WSAFLEAADNLRLIQ..VP-----...--KGP..VE.....GYEENE.EFLRTMHHLLLEVEVIE
   8 WAALVQAADTLNLAE..VP-----...--KEP..TE.....GYEHDE.TFLRKMHHVLLEVDVLE
   9 WPAVLTVAAELGNNA..LPPTKPS...FPSSI..QE.....LTDDDM.AILNDLHTLLLQTSIAE
  10 WAALVQAADTLNLAE..VP-----...--KEP..TE.....GYEHDE.TFLRKMHHVLLEVDVLE
  11 WAALVQAADTLNLAE..VP-----...--KEP..TE.....GYEHDE.TFLRKMQHVLLEVDVLE
  12 WSAFLEAADNLRLIQ..VP-----...--KGP..VE.....GYEENE.EFLRTMHHLLLEVEVIE
  13 WAALVQAADTLNLAE..VP-----...--KEP..TE.....GYEHDE.TFLRKMHHVLLEVDVLE
  14 WDAIVMVAADLGNSS..IPAQRPS...FPATA..AE.....LSEDDA.AILRDIHVLLLQTSIIE
  15 WKALVEGARSMGYAE..LPEESPD...-----..AA.....VLKSDE.PFLKKLHHALLELHLEE
  16 WNVLYNAAQSIGQL-..-----EG...LPKDV..VE.....NYENDH.EFLKKAHHALLEIDIIN
  17 WAALLEAADHVRTLL..PTS----...PAQCT..PW.....GYEHNE.EFLRKMHHVLLEVEVLE
  18 WDAIIKVAADLGNTS..LPPTKPE...---DL..DP.....IMEDNQ.VILKDLHNLLVETHILE
  19 WQAVVSVASDLGNTE..LPPNKPE...FEENL..--.....-TDEDM.VILRDLHTLLIQTNIVE
  20 WSAFLEAADSLRLIQ..VP-----...--KGP..VE.....GYEENE.EFLRTMHHLLLEVEVIE
  21 WDGLRVTANELGFSN..LPEKKPE...-----..-G.....EALNDE.QTLKDLHRLLLETHVIE
  22 WEAIKLAATHVGA--..------D...LPATL..PE.....DIASDT.ETLQKLHHILMEVDVVE
  23 WPAVVRVAHDLGNDA..LPMEKPE...FQVNS..EG.....EFDADQvAVLRDLHTLLLQTSIVE
  24 WPALVKTARSLGDTT..LPDQGPD...PSKP-..--.....--LEDE.ALIKLLHHVLLEIHVVE
  25 WSAISAAATNIGS--..------D...IPSAM..PA.....DIQNDM.ETLQKLHHILLEVDVVE
  26 WSAFLEAADSLRLIQ..MP-----...--KGP..VE.....GYEENE.EFLRTMHHLLLEVEVIE
  27 WKALVDGARSMEYTE..LPDNAPD...-----..TT.....TLESDE.TFLRKFHHALLELHLEE
  28 WKALVEGARSMGYAE..LPEESPD...-----..AA.....VLKSDE.PFLKKLHHALLELHLEE
  29 WKALVEGARSMGYAE..LPEESPD...-----..AA.....VLKSDE.PFLKKLHHALLELHLEE
  30 WGALVQAAEELGQ--..----KQD...LPDQV..VA.....DYEKDE.EFLRKVHRVLLEVEVME
  31 WNAIIQVAKDLGNES..LPPTKPE...---DL..DP.....IMEDNQ.AILKDLHTLLVETQIIE
  32 WTALYETACGINM--..----NGS...LPAQP..VE.....NYESDE.EFLKEAHRVLLEIEIVE
  33 WNALLKTTRQLGNYS..LPDEKPD...LVD--..--.....--DSDE.VLLKSLHNVLLETEITE
  34 WHALQIMANELGFPK..ILDKKPE...-----..-G.....DELKDE.QILKELHRLLLETHINE
  35 WAALVKVANDLGNES..LPDVKPE...IDEPF..--.....-AEGNQ.GLLQELHSLLIETCIVE
  36 WPALVQAAEWLGQ--..----SQE...LPDTL..IP.....DYENDE.EFLRKVHRVLLEVEVIE
  37 WGALVEAAESLGH--..----GSD...LPREL..ET.....GYEKNE.DFLKKVHHVLLEVEVIE
  38 WDALQTTANELGFAG..LVDSKPE...-----..-K.....DQLQNE.QLLRDLHRLLLETSVVE
  39 WSAVYGAAQVAE---..---LTED...IPAVQ..PE.....NIVENE.LLLQKLHHLLFEIDVLE
  40 WNALAITVHNLAK--..----NKE...FPEKF..SP.....ALLDDQ.KFMQELHRILMETHIIE
  41 WSAVYGAAQVAE---..---LAED...IPAVQ..PE.....SIVDNE.QLLQKLHHLLFEIDVLE
  42 WAALRTTSTELGFPT..LPEQPPS...-----..PE.....DLQSDE.ALLKELHELLMETQMME
  43 WKAFVEASRGMGYTE..LPEEA--...-----..DS.....SMLDSN.EFLNRFHHALLELHLEE
  44 WEALRTTASELGFPQ..LPEQAPT...-----..AV.....ELKGDD.KTLRDLHHLLLETQMSE
  45 WKALVDTARSLGDTS..LPDTMPE...-----..--.....--NWTD.EEIQALHHVLFELHVEE
  46 WLGIAEISIKFNI--..------P...IQLDT..TK.....HSLEDE.EFLKTLHNLLCNLKVIT
  47 WPALVAATQALGLPE..LLPEAPP...TDAELsaEG.....AAADEG.SALRRLHRALLEIHIEE
  48 WKALVDGARSMEYTE..LPDNAPD...-----..TT.....TLESDE.TFLRKFHHALLELHLEE
  49 WSVVKSVADEIGEDY..IP----C...LPQEV..PS.....NYSENE.EFLKLAHRALLEVDVME
  50 WNGLVTSAANIGL--..------A...VPPTL..PE.....DWKTNQ.QFLQALWDVVMDCQVIE
  51 YKALYETAKSLGI--..------D...LPVNF..VN.....EDLENE.NFINAVHHAIFDFHVLE
  52 YKALYETAKSLGI--..------D...LPVNF..VN.....EDLENE.NFINAVHHAIFNFHVLE
  53 YDVLYNTAKQFGI--..------N...LLASY..NS.....DHLEDE.EFLNSVHHALFKVHIME
  54 YTYLVEAFNSLRSQK..QDQVDAGnvlPEKLE..DV.....DLSDDS.RDLKAVHYAIQDVAIRE
  55 YEALIVAAAAVNQSD..RIPR---...--EKP..EK.....WDELTD.EQLRVFHHLLMNIDVID
  56 YGFILAAFNAMKDGQqdLLESASH...LPKSL..EDv....DLSDQS.EDLKAIHHVVQEMAVRN
  57 WAALVQAADTLNLAE..VP-----...--KEP..TE.....GYEHDE.TFLRKMHHVLLEVRILG
  58 YPMLYGMVGHA----..----VEG...LPPDL..PD.....DYDSNQ.EFLTVLAYTLYGFIILE
  59 YASLRTTFHALREAH..ESVRGPS...HDEGA..DTa17gaDFSDHS.AFLRTAHYAMNVVAVRN
  60 WGALVEAAESLGH--..----GSD...LPREL..ET.....GYEKNE.DFLKKVHHVLLEVEVIE
  61 WGALVQAAEELGQ--..----KQD...LPDQV..VA.....DYEKDE.EFLRKVHRVLL------
  62 WAALLEAAKALDLL-..------K...VSKGL..IQ.....GYEHYE.KFPREMHHMLLELDVLE
  63 WAALLEAAKTLDLL-..------E...VSKGL..IQ.....GYEHYE.KFPREMHHMLLELDVLE
  64 ---------------..-------...-----..--.....------.---RTMHHVLLEVDVLE
  65 ---------------..-------...-----..--.....------.---RTMHHVLLEVDVLE
  66 ---------------..-------...-----..--.....------.------HHVLLEVEVLE
  67 YEVLYNTAKQFGV--..------S...LLSSY..NN.....NHLEDE.GFLNSVHHALFKVH---
  68 GERLKSLVNSLRDFH..GRELSEQ...DISSF..VE.....NPGDDE.----KIKEFLFGIDVVE
  69 WKRILNSCIA-GKIA..VPEKYAL...HDSDV..VD.....PEALTD.EEVDQFYELLFLQAVVE
  70 WAVLVQAADTSILA-..------E...VNKES..SD.....SYEQDE.MFLRKM-----------
  71 ---------------..-------...-----..--.....------.-------------EILE
  72 ---------------..-------...-----..--.....------.-------------EILT
  73 ---------------..-------...-----..--.....------.-------------EIIS
  74 ---------------..-------...-----..--.....------.-------------EVMA
  75 ---------------..-------...-----..--.....------.----------------E
  76 ---------------..-------...-----..--.....------.-------------EVIS
  77 ---------------..-------...-----..--.....------.-------------EILS
  78 ---------------..-------...-----..--.....------.-----------ERDIEE
  79 ---------------..-------...-----..--.....------.------------IEIIT
  80 ---------------..-------...-----..--.....------.--------------VIS


      110       120            130     
       |         |              |     
   1 GEMKCRNCGHIYYIKNG.....IPNLLLPPHLV
   2 GTLQCPESGRLFPISRG.....IPNMLLNDEE-
   3 GTLQCPESGRLFPISRG.....IPNMLLNDEE-
   4 GTLQCPESGRVFPISRG.....IPNMLLSDEE-
   5 GTLQCPESGRMFPISRG.....IPNMLLSEEE-
   6 GTLQCPESGRLFPISRG.....IPNMLLSDEE-
   7 GTLQCPESGRMFPISRG.....IPNMLLSGEE-
   8 GTLQCPESGRLLPISRG.....IPNMLLNDEE-
   9 GEMKCRNCGHIYYIKNG.....IPNLLLPPHL-
  10 GTLQCPESGRLFPISRG.....IPNMLLNDEE-
  11 GTLQCPESGRLFPISRG.....IPNMLLNDEE-
  12 GTLQCPESGRMFPISRG.....IPNMLQSEEE-
  13 GTLQCPESGRLFPISRG.....IPNMLLND---
  14 GEMQCRNCGHTYYIKNS.....IPNLLLPPH--
  15 GALVCPETGRKFPVNKG.....IPNMLLHEDEV
  16 GELICPETGRKFPINNG.....IPNLLLNEDEV
  17 GTLQCPESGRVFPISRG.....IPNMLLSDEE-
  18 GKMTCRNCGHIYYIKNS.....IPNFLLPPH--
  19 GQMQCKNCEHIYYIKNS.....IPNLLLPPH--
  20 GTLQCPESGRMFPISRG.....IPNMLLSEEE-
  21 GKLVCGNCGHEYLIKEG.....IANFLLPSH--
  22 GTLECPETGRVFPISDG.....IPNMLLNEDEV
  23 GQMSCRNCGHIYYIKNS.....IPNLLLPPH--
  24 GQMICPNCSHIYQIRSG.....IPNMLLAEHEI
  25 GTLECPETGRIFPINNG.....IPNMLLNEDEV
  26 GTLQCPESGRMFPISRG.....IPNMLLSEEE-
  27 GSLVCPETGRKFSVSKG.....IPNMLLHEDEV
  28 GALVCPETGRKFPVNKG.....IPNMLLHEDEV
  29 GALVCPETGRKFPVNKG.....IPNMLLHEDEL
  30 GCLKCPESGREFPISRG.....IPNMLLNEDE-
  31 GKMICKNCQHIYYIKNS.....IPNFLLPPH--
  32 GNLVCPESGRKFPIKNG.....IANMLLNEDEV
  33 GKMVCGNCGHVYPIFEG.....IPNMLLSESEI
  34 GKLTCGNCGHEYLIKEG.....IANFLLPSHL-
  35 GTMKCENCGHTYFIKNS.....IPNFLLPPH--
  36 GCLQCPESGREFPISKG.....VPNMLLNEG--
  37 GALKCPESGTEFPITRG.....IPNMLINEEE-
  38 GKLVCGNCGHEYKIKEG.....IANFLLPSHL-
  39 GQLECPETGRVFPISDG.....IPNMLLNEDEV
  40 GALICEGCNKRYPIKNG.....IPNMILNDEEV
  41 GQLECPETGRIFPITDG.....IPNMLLNEDEV
  42 GKLVCGHCGHEYAVKNG.....VANFLLPSHL-
  43 GALVCPETGRRFPVKKG.....IPNMLLHEDEV
  44 GKLVCGSCGHEYAVKEG.....IANFLLPSHL-
  45 GIMTCRGCGHAYPVANG.....IPNMLLAEHEV
  46 GSLTCPNCQRVYPIDKG.....IPNMLLREDEI
  47 GALVCPDTDRCFPISRG.....VPNMLLHEDEV
  48 GSLVCPETGRKFSVSKG.....IPNMLLHEDEV
  49 GVLVCPETGREFTISNG.....IPNMLVNE---
  50 GELICPVCGRHYPIHNG.....IPNMLLSEQE-
  51 GRLVCPSCSHNYKISKG.....-----------
  52 GRLVCPSCSHNYKISKG.....IPDML------
  53 GSLVCPKCNISFPIKDGkf9lcIPNML------
  54 GALRCPQCKREYPIREF.....IPDMIA-----
  55 GELICPETKTVFPIRDG.....IPNMLKV----
  56 GRLVCQQCQREYPIRDF.....IPDMVI-----
  57 HRLP-------------.....-----------
  58 GSITCNSCGLVFPITEG.....IPRMRLPEED-
  59 GTLECPACKTTFSINDF.....IPNFV------
  60 GALKCPESGTEFPITRG.....IPNMLINEEE-
  61 -----------------.....-----------
  62 DTLQCTESGHLSHISHG.....DPNMLPSDEEM
  63 DTLQCAESGHLSHISRG.....DPNMLLSDEEM
  64 GTLQCPESGRVFPISRR.....IPNMLLNDEE-
  65 GTLQCPESGRVFPISRR.....IPNMLLNDEE-
  66 GTLQCPESGRVFPISRG.....IPNMLLSDEE-
  67 -----------------.....-----------
  68 GSLRCDMCGLIYPIKGS.....I----------
  69 GELICSGCNKAYEIRNR.....IPRL-------
  70 -----------------.....-----------
  71 GRLLCEECGEEYPIEDG.....IPNLLPP----
  72 GRLTCRSCGEVYPIEEG.....IPNMLPP----
  73 GTLYCSKCNEYFPITDG.....IPNMLPP----
  74 GTLTCTDCGETYPIEDG.....IPNLLPP----
  75 GSLTCPKCNISFPIKDG.....IPNMLAA----
  76 GTLYCPVCKEHYPIDEG.....IPNLLPP----
  77 GELTCTECSETFPIEDG.....IPNLLPP----
  78 GVLVCPACGRWYPIVEG.....IPVM-------
  79 GSLICHACSVTYPIEDG.....IPNLL------
  80 GTLYCPICKEHYPVDEG.....IPNLLPP----