a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0377 APC6107, Sulfolobus solfataricus P2, 101 res
- gi|13814625|gb|AAK41639.1|_2:101 Conserved hypothetical protein [Sulfolobus solfataricus P2]
- gi|15898244|ref|NP_342849.1| hypothetical protein SSO1404 [Sulfolobus solfataricus P2]
- gi|21226660|ref|NP_632582.1|_1:92 hypothetical protein MM0558 [Methanosarcina mazei Go1]
- gi|20904943|gb|AAM30254.1| hypothetical protein MM_0558 [Methanosarcina mazei Go1]
- gi|88951335|ref|ZP_01153849.1|_1:89 Protein of unknown function DUF196 [Methanosaeta thermophila PT]
- gi|88929457|gb|EAR48406.1| Protein of unknown function DUF196 [Methanosaeta thermophila PT]
- gi|67875871|ref|ZP_00504998.1|_1:92 Protein of unknown function DUF196 [Clostridium thermocellum ATCC 27405]
- gi|67850349|gb|EAM45929.1| Protein of unknown function DUF196 [Clostridium thermocellum ATCC 27405]
- gi|76258759|ref|ZP_00766413.1|_1:91 Protein of unknown function DUF196 [Chloroflexus aurantiacus J-10-fl]
- gi|76166488|gb|EAO60614.1| Protein of unknown function DUF196 [Chloroflexus aurantiacus J-10-fl]
- gi|68568380|gb|AAY81309.1|_1:94 conserved Archaeal protein [Sulfolobus acidocaldarius DSM 639]
- gi|70607732|ref|YP_256602.1| hypothetical protein Saci_2010 [Sulfolobus acidocaldarius DSM 639]
- gi|89211076|ref|ZP_01189454.1|_1:88 Protein of unknown function DUF196 [Halothermothrix orenii H 168]
- gi|89159301|gb|EAR78971.1| Protein of unknown function DUF196 [Halothermothrix orenii H 168]
- gi|38505761|ref|NP_942381.1|_3:90 hypothetical protein ssr7093 [Synechocystis sp. PCC 6803]
- gi|38423785|dbj|BAD01995.1| ssr7093 [Synechocystis sp. PCC 6803]
- gi|106892165|ref|ZP_01359341.1|_1:89 Protein of unknown function DUF196 [Roseiflexus sp. RS-1]
- gi|106768997|gb|EAT25656.1| Protein of unknown function DUF196 [Roseiflexus sp. RS-1]
- gi|91201520|emb|CAJ74580.1|_1:89 conserved hypothetical protein [Candidatus Kuenenia stuttgartiensis]
- gi|86605589|ref|YP_474352.1|_1:90 CRISPR-associated protein Cas2 [Synechococcus sp. JA-3-3Ab]
- gi|86554131|gb|ABC99089.1| CRISPR-associated protein Cas2 [Synechococcus sp. JA-3-3Ab]
- gi|17129727|dbj|BAB72340.1|_3:92 asr0382 [Nostoc sp. PCC 7120]
- gi|17227878|ref|NP_484426.1| hypothetical protein asr0382 [Nostoc sp. PCC 7120]
- gi|86608316|ref|YP_477078.1|_3:90 CRISPR-associated protein Cas2 [Synechococcus sp. JA-2-3B'a(2-13)]
- gi|86607159|ref|YP_475922.1| CRISPR-associated protein Cas2 [Synechococcus sp. JA-3-3Ab]
- gi|86556858|gb|ABD01815.1| CRISPR-associated protein Cas2 [Synechococcus sp. JA-2-3B'a(2-13)]
- gi|86555701|gb|ABD00659.1| CRISPR-associated protein Cas2 [Synechococcus sp. JA-3-3Ab]
- gi|15620980|dbj|BAB64976.1|_10:98 104aa long conserved hypothetical protein [Sulfolobus tokodaii str. 7]
- gi|15920198|ref|NP_375867.1| hypothetical protein ST0025 [Sulfolobus tokodaii str. 7]
- gi|76258126|ref|ZP_00765783.1|_1:91 Protein of unknown function DUF196 [Chloroflexus aurantiacus J-10-fl]
- gi|76167212|gb|EAO61335.1| Protein of unknown function DUF196 [Chloroflexus aurantiacus J-10-fl]
- gi|86140611|ref|ZP_01059170.1|_1:89 hypothetical protein MED217_15705 [Flavobacterium sp. MED217]
- gi|85832553|gb|EAQ51002.1| hypothetical protein MED217_15705 [Flavobacterium sp. MED217]
- gi|11499460|ref|NP_070701.1|_1:85 hypothetical protein AF1876 [Archaeoglobus fulgidus DSM 4304]
- gi|2648668|gb|AAB89376.1| conserved hypothetical protein [Archaeoglobus fulgidus DSM 4304]
- gi|14141822|gb|AAK54438.1|_1:84 Conserved hypothetical protein [Sulfolobus solfataricus P2]
- gi|67935815|ref|ZP_00528832.1|_2:87 Protein of unknown function DUF196 [Chlorobium phaeobacteroides DSM 266]
- gi|67775210|gb|EAM34879.1| Protein of unknown function DUF196 [Chlorobium phaeobacteroides DSM 266]
- gi|38505740|ref|NP_942360.1|_3:91 hypothetical protein ssr7072 [Synechocystis sp. PCC 6803]
- gi|38423764|dbj|BAD01974.1| ssr7072 [Synechocystis sp. PCC 6803]
- gi|18159177|gb|AAL62620.1|_1:83 conserved hypothetical protein [Pyrobaculum aerophilum str. IM2]
- gi|18311771|ref|NP_558438.1| hypothetical protein PAE0199 [Pyrobaculum aerophilum str. IM2]
- gi|46255266|ref|YP_006178.1|_4:90 hypothetical protein TT_P0195 [Thermus thermophilus HB27]
- gi|55773579|dbj|BAD72019.1| conserved hypothetical protein [Thermus thermophilus HB8]
- gi|46198115|gb|AAS82525.1| hypothetical conserved protein [Thermus thermophilus HB27]
- gi|55978406|ref|YP_145462.1| hypothetical protein TTHB223 [Thermus thermophilus HB8]
- gi|15623767|dbj|BAB67754.1|_3:85 94aa long conserved hypothetical protein [Sulfolobus tokodaii str. 7]
- gi|15922976|ref|NP_378645.1| hypothetical protein STS264 [Sulfolobus tokodaii str. 7]
- gi|88602028|ref|YP_502206.1|_5:92 Protein of unknown function DUF196 [Methanospirillum hungatei JF-1]
- gi|88187490|gb|ABD40487.1| Protein of unknown function DUF196 [Methanospirillum hungatei JF-1]
- gi|76259343|ref|ZP_00766993.1|_7:87 Protein of unknown function DUF196 [Chloroflexus aurantiacus J-10-fl]
- gi|76165870|gb|EAO60000.1| Protein of unknown function DUF196 [Chloroflexus aurantiacus J-10-fl]
- gi|106890906|ref|ZP_01358097.1|_1:80 Protein of unknown function DUF196 [Roseiflexus sp. RS-1]
- gi|106770213|gb|EAT26857.1| Protein of unknown function DUF196 [Roseiflexus sp. RS-1]
- gi|86604865|ref|YP_473628.1|_18:102 CRISPR-associated protein Cas2 [Synechococcus sp. JA-3-3Ab]
- gi|86553407|gb|ABC98365.1| CRISPR-associated protein Cas2 [Synechococcus sp. JA-3-3Ab]
- gi|71546645|ref|ZP_00667422.1|_1:84 Protein of unknown function DUF196 [Syntrophobacter fumaroxidans MPOB]
- gi|71487616|gb|EAO20061.1| Protein of unknown function DUF196 [Syntrophobacter fumaroxidans MPOB]
- gi|38505685|ref|NP_942305.1|_1:89 hypothetical protein ssr7017 [Synechocystis sp. PCC 6803]
- gi|38423709|dbj|BAD01919.1| ssr7017 [Synechocystis sp. PCC 6803]
- gi|83592489|ref|YP_426241.1|_35:117 Protein of unknown function DUF196 [Rhodospirillum rubrum ATCC 11170]
- gi|83575403|gb|ABC21954.1| Protein of unknown function DUF196 [Rhodospirillum rubrum ATCC 11170]
- gi|46255172|ref|YP_006084.1|_5:84 hypothetical protein TT_P0101 [Thermus thermophilus HB27]
- gi|46198021|gb|AAS82431.1| hypothetical protein TT_P0101 [Thermus thermophilus HB27]
- gi|83753848|pdb|1ZPW|X Chain X, Crystal Structure Of A Hypothetical Protein Tt1823 From Thermus Thermophilus [Taxonomy]
- gi|37677206|ref|NP_937602.1|_1:68 hypothetical protein VVA1546 [Vibrio vulnificus YJ016]
- gi|37201751|dbj|BAC97572.1| conserved hypothetical protein [Vibrio vulnificus YJ016]
- gi|88952020|ref|ZP_01154494.1|_1:82 Protein of unknown function DUF196 [Methanosaeta thermophila PT]
- gi|88929030|gb|EAR47982.1| Protein of unknown function DUF196 [Methanosaeta thermophila PT]
- gi|13882655|gb|AAK47208.1|_26:90 CRISPR-associated protein Cas2 [Mycobacterium tuberculosis CDC1551]
- gi|31793992|ref|NP_856485.1| hypothetical protein Mb2840c [Mycobacterium bovis AF2122/97]
- gi|31619586|emb|CAD95025.1| CONSERVED HYPOTHETICAL PROTEIN [Mycobacterium bovis AF2122/97]
- gi|1648905|emb|CAB03632.1| CONSERVED HYPOTHETICAL PROTEIN [Mycobacterium tuberculosis H37Rv]
- gi|15609953|ref|NP_217332.1| hypothetical protein Rv2816c [Mycobacterium tuberculosis H37Rv]
- gi|15842357|ref|NP_337394.1| CRISPR-associated protein Cas2 [Mycobacterium tuberculosis CDC1551]
- gi|76783291|ref|ZP_00770483.1| COG1343: Uncharacterized protein predicted to be involved in DNA repair [Mycobacterium tuberculosis F11]
- gi|81253172|ref|ZP_00877733.1| COG1343: Uncharacterized protein predicted to be involved in DNA repair [Mycobacterium tuberculosis C]
- gi|37677205|ref|NP_937601.1|_15:88 hypothetical protein VVA1545 [Vibrio vulnificus YJ016]
- gi|37201750|dbj|BAC97571.1| hypothetical protein [Vibrio vulnificus YJ016]
- gi|71490719|gb|EAO23076.1|_22:89 Protein of unknown function DUF196 [Syntrophomonas wolfei subsp. wolfei str. Goettingen]
- gi|71542873|ref|ZP_00664394.1| Protein of unknown function DUF196 [Syntrophomonas wolfei str. Goettingen]
- gi|85858453|ref|YP_460655.1|_1:79 hypothetical cytosolic protein [Syntrophus aciditrophicus SB]
- gi|85721544|gb|ABC76487.1| hypothetical cytosolic protein [Syntrophus aciditrophicus SB]
- gi|76802277|ref|YP_327285.1|_2:85 hypothetical protein NP3276A [Natronomonas pharaonis DSM 2160]
- gi|76558142|emb|CAI49729.1| conserved hypothetical protein [Natronomonas pharaonis DSM 2160]
- gi|53749925|emb|CAH11309.1|_9:93 hypothetical protein [Legionella pneumophila str. Paris]
- gi|54296140|ref|YP_122509.1| hypothetical protein lpp0162 [Legionella pneumophila str. Paris]
- gi|68568255|gb|AAY81184.1|_1:84 conserved Archaeal protein [Sulfolobus acidocaldarius DSM 639]
- gi|70607607|ref|YP_256477.1| hypothetical protein Saci_1879 [Sulfolobus acidocaldarius DSM 639]
- gi|18159098|gb|AAL62547.1|_1:81 conserved hypothetical protein [Pyrobaculum aerophilum str. IM2]
- gi|18311698|ref|NP_558365.1| hypothetical protein PAE0080 [Pyrobaculum aerophilum str. IM2]
- gi|88603115|ref|YP_503293.1|_5:79 protein of unknown function DUF196 [Methanospirillum hungatei JF-1]
- gi|88188577|gb|ABD41574.1| protein of unknown function DUF196 [Methanospirillum hungatei JF-1]
- gi|90573471|ref|ZP_01229986.1|_4:72 hypothetical protein CdifQ_02003237 [Clostridium difficile QCD-32g58]
- gi|109673899|ref|ZP_01376068.1|_1:85 hypothetical protein Ccur5_01001215 [Campylobacter curvus 525.92]
- gi|52307741|gb|AAU38241.1|_1:69 unknown [Mannheimia succiniciproducens MBEL55E]
- gi|52425689|ref|YP_088826.1| hypothetical protein MS1634 [Mannheimia succiniciproducens MBEL55E]
- gi|33359379|ref|NP_877829.1|_1:80 hypothetical protein PH1244.1n [Pyrococcus horikoshii OT3]
- gi|89256629|ref|YP_513991.1|_7:77 hypothetical protein FTL_1321 [Francisella tularensis subsp. holarctica]
- gi|89144460|emb|CAJ79760.1| conserved hypothetical protein [Francisella tularensis subsp. holarctica]
- gi|11500010|ref|NP_071256.1|_6:81 hypothetical protein AF2434 [Archaeoglobus fulgidus DSM 4304]
- gi|2650655|gb|AAB91229.1| conserved hypothetical protein [Archaeoglobus fulgidus DSM 4304]
- gi|57158704|dbj|BAD84634.1|_1:72 hypothetical protein, conserved, DUF196 family [Thermococcus kodakarensis KOD1]
- gi|57640380|ref|YP_182858.1| hypothetical protein TK0445 [Thermococcus kodakarensis KOD1]
- gi|18893192|gb|AAL81241.1|_1:80 hypothetical protein [Pyrococcus furiosus DSM 3638]
- gi|52216699|dbj|BAD49292.1|_1:78 conserved hypothetical protein [Bacteroides fragilis YCH46]
- gi|53713834|ref|YP_099826.1| hypothetical protein BF2543 [Bacteroides fragilis YCH46]
- gi|30248141|ref|NP_840211.1|_16:84 hypothetical protein NE0110 [Nitrosomonas europaea ATCC 19718]
- gi|30180026|emb|CAD84021.1| hypothetical protein [Nitrosomonas europaea ATCC 19718]
- gi|109672068|ref|ZP_01374310.1|_1:83 hypothetical protein Ccon1_01001059 [Campylobacter concisus 13826]
- gi|34483652|emb|CAE10649.1|_7:56 hypothetical protein [Wolinella succinogenes]
- gi|34557934|ref|NP_907749.1| hypothetical protein WS1616 [Wolinella succinogenes DSM 1740]
- gi|33359542|ref|NP_578846.2|_4:83 hypothetical protein PF1117 [Pyrococcus furiosus DSM 3638]
- gi|60493487|emb|CAH08273.1|_1:77 conserved hypothetical protein [Bacteroides fragilis NCTC 9343]
- gi|60682053|ref|YP_212197.1| hypothetical protein BF2573 [Bacteroides fragilis NCTC 9343]
- gi|33359262|ref|NP_877738.1|_4:72 hypothetical protein PH0173.1n [Pyrococcus horikoshii OT3]
- gi|55229004|gb|AAV44427.1|_4:80 CRISPR-associated protein Cas2 [Haloarcula marismortui ATCC 43049]
- gi|55376279|ref|YP_134133.1| CRISPR-associated protein Cas2 [Haloarcula marismortui ATCC 43049]
- gi|72395015|gb|AAZ69288.1|_1:64 conserved hypothetical protein [Methanosarcina barkeri str. fusaro]
- gi|73667853|ref|YP_303868.1| hypothetical protein Mbar_A0304 [Methanosarcina barkeri str. fusaro]
- gi|31541727|gb|AAP57026.1|_24:107 conserved hypothetical protein [Mycoplasma gallisepticum R]
- gi|31544880|ref|NP_853458.1| hypothetical protein MGA_0525 [Mycoplasma gallisepticum R]
- gi|83590561|ref|YP_430570.1|_3:80 Protein of unknown function DUF196 [Moorella thermoacetica ATCC 39073]
- gi|83573475|gb|ABC20027.1| Protein of unknown function DUF196 [Moorella thermoacetica ATCC 39073]
- gi|68233545|ref|ZP_00572662.1|_1:78 Protein of unknown function DUF196 [Frankia sp. EAN1pec]
- gi|68198821|gb|EAN13076.1| Protein of unknown function DUF196 [Frankia sp. EAN1pec]

              10                 20              30         40        5
              |                  |               |          |         
   1 MAMLYLIFYDIT....DDNLR.....NRVAEF....LKK..KGLDRIQYSVFMG.DLNSSRLKDV
   2 -AMLYLIFYDIT....DDNLR.....NRVAEF....LKK..KGLDRIQYSVFMG.DLNSSRLKDV
   3 --MLVWVIYDIT....ENRIR.....QKVSDC....CKS..YGLYRVQKSVFLG.DLNSNDRDSL
   4 --MLVWVIYDIS....DDRTR.....SRVAKI....CKN..YGLYRVQKSAFLG.DLNRNESDSL
   5 --MLTWVIYDIA....SNKTR.....NNIIKK....CKN..AGLYRVQKSVFLG.DIESNKFDEL
   6 MKMFTVISYDIV....DDQRR.....TSVMKV....LKG..YG-VRVQYSVFEA.ILDAREFHDL
   7 --MLYVVFYDIS....DDDLR.....GKVADF....LKK..KGLVRLQFSVFFG.ELNSSRVKDL
   8 --MLVWFIYDIV....EDKPR.....KKIADK....AIE..QGLYRVQKSVFLG.DIEPNLLDEL
   9 ---LYVIAYDIP....DDRRR.....KKMADL....LEG..YG-QRVQYSVFEC.TLSKSKFNEL
  10 --MFTIISYDIV....DDRRR.....TNVMKY....LKG..WG-TRVQYSVFEC.ILDARAFATV
  11 --MFYLVSYDIP....ETRRR.....TKLAKI....LED..FG-DRVQYSVFEC.ILDEKLLGKM
  12 --MLWLVCYDVV....DDKRR.....HQLAKR....LEQ..CC-QRVQYSVFEC.PLDTAELEEK
  13 --KLYLVCYDIP....DDKRR.....TKLAKL....IEQ..RC-QRVQYSVFEC.PLEESVLNYQ
  14 ---LYVVTYDTP....CDKRR.....KKIADL....LEG..YG-KRVQYSVFEC.VLDKDKFEEL
  15 -EMLYIVFYDIS....DDGMR.....NRVADV....LKK..KGLVRVQYSVFIG.DLNSARLKDV
  16 --MFYLISYDIS....VDQRR.....LKIAKL....LEG..YG-QRVLESVFEC.DLELPAYRQL
  17 --MITWVLYDIK....NNAAR.....SQVSKA....CKH..AGLYRVQYSCFLG.TLNANEKDSL
  18 --MLHLVVYDIS....DDGSR.....ARLAKL....LEK..FGLQRVQYSAFRG.ELNPNDREVL
  19 --MKLLVVYDVS....DDSKR.....NKLANN....LKK..LGLERIQRSAFEG.DIDSQRVKDL
  20 -----LVSYDIC....DIKRL.....PRVAKL....MEG..YG-VRVQYSVFEC.SLTQRQLMEL
  21 ---FWLVCYDVR....DDKRR.....RKLAKL....LEQ..RC-QRVQYSVFEC.PLPEKVLTDL
  22 --MYVVVAYDIT....EDEVR.....NKVADA....LKA..YGLERIQRSVFVG.RINPALLKDL
  23 --LYLVIAYDTP....DDRRR.....ARLAKL....LKG..FG-ERRQYSVFEA.RLTREQWAHL
  24 -KMWVIVVYDIS....DDEKR.....NKIARE....LQR..LGLSRIQRSAFVG.DIDSQRFKDL
  25 ---HLIVCYDVE....KTKDR.....NKVIKV....LEY..YGLIRVQYSVFMG.SLTETRLHQM
  26 --MQCLVIYDIP....NDRAR.....QRVADA....CLD..YGLQRIQYSAFAG.NLSRTHQRAL
  27 --MRCLLIYDIP....DDRVR.....QKIADA....CLD..YGLQRIQYSAFAG.NLSRTHQREL
  28 ---LWLVCYDVV....DDKRR.....QQLAKR....LEQ..CC-QRAQYSVVEC.PLDTAELEKS
  29 --MFYVVSYDIS....DDRVR.....YRVAKV....LKA..YG-VRVQKSVFECpDLTEKRFLKM
  30 --MLYLIIYDVPatkaGNKRR.....TRLFDL....LSG..YG-KWRQFSVFEC.FLSVKQFAKL
  31 ----YVICYDIV....DDKRR.....LKVAKC....LDS..YG-SRVQFSVFEV.LVSKPLMTRM
  32 ---LYAVAYDIP....DDTRR.....VKLANL....LKS..YG-ERVQLSVFEC.YLDERLLEDL
  33 --MLWLISFDIS....DDKRR.....RRAVKL....LLG..YG-NRTQYSVFEC.LLKRSQLRQI
  34 --MRLAVTYDIS....DNRIR.....TRVFRI....LES..YG-AWKQYSVFEL.EISDVQRLEM
  35 --MFVLVIYDIS....DNRRR.....ASLAKI....LAG..FG-YRVQESAFEA.MLTKGQLAKL
  36 ---HYVICYDIS....ERQTR.....YRVEKA....LLG..YG-ERVQYSVFEC.RLTTGQFFAL
  37 --YLVVVIYDIV....DNRRR.....AAFAKY....LKG..FG-VRVQKSAFEC.ILPDAKYQKL
  38 --MIVLITYDIT....EPKRL.....TALHHF....LKE..FG-LNTQKSVFEC.DIDEAGIRKI
  39 -TMRLAVAYDVS....DDTNR.....RHVYRT....LQR..YG-AWRQYSVFEL.EISKTDRVEL
  40 ----YIVSYDIR....DNSIR.....RTIYER....LKD..IGLTPVQKSVFWG.YLNEPEKRYL
  41 --MYVVVAYDIS....DEKVR.....GKVRRL....LRR..YGLSFISRSVYAG.RLSWNRALLI
  42 --MIWLAVYDIE....DDGER.....AKASAI....LQA..WGFVRVQRSFYVG.RMPRGKAADL
  43 -----VITYDIR....KDKIR.....NKLFRL....LER..YG-AWKQYSVFEL.EINPVHKVEL
  44 --MFVIVTYDIV....EARSL.....NRIRRI....LRK..YL-TWTQNSVFEG.NITDGKLHKC
  45 --MYAILFYDIA....GAEQKeknnaNRIRKA....VEK..FL-PRVQFSVFEG.EIRASDFKKL
  46 --MRYLIGYDIT....DSKRL.....QRIYRR....MIK..FA-TPLQYSVFLF.NGTKEQLDKY
  47 --MYIVVVYDIN....VER-V.....NKVKKF....LR-..MHLNWVQNSVFEG.EVTLAEYERI
  48 ----YLIAYDIE....DNKTR.....TIIYKQ....LLA..YGLKAVQKSVFWG.YVSIAEFNAI
  49 ---YVIVAYDVN....VE-RV.....NRVKKF....LRR..YL-NWVQNSLFEG.ELSSADLEEV
  50 --MYIIVVYDVS....VER-V.....NRVKKF....LRQ..HL-HWVQNSVFEG.EVTLAEFERI
  51 --MYIVVVYDVG....VER-V.....NKVKKF....LRM..-HLNWVQNSVFEG.EVTLAEFERI
  52 --MYVILVYDFG....E-KRV.....SKMLRL....CRR..YL-NWIQNSVFEG.ELSEVRLKEL
  53 -----IICYDIT....DPRRL.....GRLYRY....LIK..RA-VPLQYSVFLF.RGDDRQLERC
  54 --MYVILFYDIA....GCEQKernnaNRIRKA....VEK..FL-PRVQFSVYEG.EIRESDFKKL
  55 ----VIVSYDIE....DNRNR.....KKLFEE....LKD..MGLSPIQKSVFWG.HLKLAEIKIL
  56 --MYIVVVYDVG....VER-V.....NKVKKF....LRM..-HLNWVQNSVFEG.EVTLAEFERI
  57 --MYVIFVYDFG....E-KRV.....SKMLRL....CRR..YL-NWIQNSVFEG.ELSEVRLKEL
  58 --MYVIVVYDVN....VE-RV.....NRVHKL....LKT..YLFWR-QNSVFEG.ELSKAQLYEL
  59 ----AIIVYDVQ....ADRT-.....PKFLKY....LRR..YL-THVQNSVFEG.ELTEGTLVEV
  60 --MYVVIVYDVG....VDRV-.....NKVRTF....LRQ..YM-NWVQNSVFEG.ELTKAELLKV
  61 --MRIVIFYDIY....ETEEV.....DKLAKKfrdnLIS..LGYFMIQYSVYCK.CIGSHTMYDY
  62 ------LIYDINte..DNDGK.....RRLVKI....MKTsrKYLSHVQKSVFEG.DITEGQISLL
  63 --MFVILVYDTA....AE-RN.....PLVLRT....CRK..YL-HWVQRSVFEG.ELSAAQYRAL


      0        60        70        80        90       100 
     |         |         |         |         |         | 
   1 EAGLKIIGNRKKLQEDERFFILIVPITENQFRERIVIGYSGSEREEKSNVVW
   2 EAGLKIIGNRKKLQEDERFFILIVPITENQFRERIVIGYSGSEREEKSNVVW
   3 ALECE------EWIDTEKDSVYVFPMDEQSFKQVKLIGQAFDKELVSDEII-
   4 ALECE-------SVIEDTDSVYVFPMCEDCFDKIKLIGTGFDRELVSGM---
   5 KLELD------SIIDKDNDSVYMFTMTKAELNKAGLLGQAFDKELVTDEII-
   6 SNQLR------KIIDPGQDSIRCYRLDQVAAQRTVIYGIGLTTTDPTHY---
   7 TAGLR--LYAKRRSEGERFNVLILPVTETQFKQRIVIGGSGEHEERGDS---
   8 LVYAE------ELIDPENDSVYAFPMCQEDFKKVEIIGQAFDKAMVN-----
   9 QKRLR------KIYQSEEDSLRFYPLSGHTLTQVDIWGEPPLTKPPGSV---
  10 VRELQ------RMIDQNTDSVRCYRLDEAAVTRIQIIGIGAVSKDPTHY---
  11 IKRIQ------EIIIAEDDSIRIYSICAGCEKRIEVMGKGKVSKIENIY---
  12 LEKSW-----LPLLNLQEDSLRAYPLDASAKQRTKVFGGPPPYEPPDYL---
  13 LEKRW-----LPILKLSEDSLRVYPLDATAKQQTRVYGGEPPYEPPDYL---
  14 KLRLR------KRVKPDEDSVRFYPLTSHALDQVEIWGGPPLTAPPHSI---
  15 VASLRVLY---RSNKEGRFSVMILPVTQAMFNQRIMIGDEFKEN--------
  16 RQKLN-----RLIKDEEGDRLRIYRLCASCREQIEIIGDGPPPETSQDIY--
  17 ELQIE------KVINEETDKVYLFRMNKEQLKDCSMLGQAFDEKLVTD----
  18 ARQVG------KFVRDDRDCIFIIPLCQRCSSTAIVISNTGVEL--------
  19 VRVVK------LIVDTNTDIVHIIPLGIRDWERRIVIGREGLE---------
  20 QRRLK------RLIKPEVDSVRFYPLCESCRDEIVILGQGTVSRDEPYY---
  21 LHRRW-----LKELNLKEDSLRAYPLQRQSRSQAKIFGSPDLYEPPDFL---
  22 VERLK------RITKGANADITIFKVDRRAIDTAIRIGPPPP----------
  23 KGKLE------ALVNKEEDVLAVYFLPPEAVGRTWRIGHEGLKRLED-----
  24 VRIMG------KLVTGKDDILHIIPLGLRDWERRVVINGDS-----------
  25 NARIK------REFTKPSIKILVIEVCNACMERALLVHEELPKVNRQF----
  26 FGEIT------RRVKGHTANVQLFVFDSKTWSDRRILEQQ------------
  27 MTEVR------RRLGKHAGNIQLFTFPDDIWNARRTIEQ-------------
  28 WL---------PLLNLEEDSLQAYPLDATAKRRTKVFGGPLPYEPPDYL---
  29 KDRLE------ALIDFTTDSVRYYRQCRGCLAQCEVSGAGELP---------
  30 QTAME------KLIKLDEDAVCIYVLDENTVQRTITYGTPQPEKP-------
  31 VRELG------ALINAKTDRISIYPQCATCDARRTDLGATVEKPV-------
  32 RRRAR------RLLDLGQDALRIYPVA----GQVEVLGVGPLPEL-------
  33 QQKMQ-------AVIEPSDRVLYYPLCGK-----------------------
  34 EAKIK-------SVIKPGDKVRIYELCERCVGAIVEIGEKSPT---------
  35 VARID-------RFAIDCDNIRIYKI--------------------------
  36 RHELR-------RWLEDGDRVNYFRLCLHCQRRRLT----------------
  37 LKGIP------KLID-KEDQVRVYKLTSN-----------------------
  38 RAYCR------NNLNIAKDSVRIYKICSRCINKVVLSGL-------------
  39 EAELE-----SHIDPSAGDRIRIYRLCSACQDATTDIGNDPP----------
  40 TNFLK-----KELAKQDTAFITPCKLAQEYEVNLINLELDELRKP-------
  41 SERVA-------KYLEERDSVVIVPVQNVDFSRTLIVTQNKISK--------
  42 LKILQ------RHVKS--GHIALIPITDELLAKALELGRPPY----------
  43 FHSIA-------DLIEDTDRVRIYDLCERCQGKITELGE-------------
  44 ISEIE------NIIDNSEDSIYVYEIKNP-----------------------
  45 TNLLQ------KECVQELDSIVIYTFNSLKYSERIVIGQD------------
  46 MQTVL------RLYNKKEDDLRIYPLPVQ-----------------------
  47 KAGLK------KIIDEDEDSVIIYKLRSMPPREILGIEKNP-----------
  48 KRLFD-----RSLTISDKVFITRVNMHEQKL---------------------
  49 KMGLR------EIINEDEDMVVIYRFRSADAFKREVMG--------------
  50 KAGIG------ELIDGDEDSVVIYKLRSMPKRE-------------------
  51 KEGLK------KIIDENSDSVIIYKLRSMPPRETLGIEKNP-----------
  52 LLLAK------GFMNPEEDCIIIFKGATQCSLEKEIVGK-------------
  53 IQDAI------ELIDEKQDDLRVYPLPGRGLK--------------------
  54 SKTLQ------KECVSELDSIVIYTFNSLKYSERIVIG--------------
  55 PNLFC-----------------------------------------------
  56 KEGLK------KIIDENSDSVIIYKLRSMPPRETLGIEKNP-----------
  57 LLLAK------GVMNPEEDCIIIFKGATQCSLEKEIVG--------------
  58 EMRLK-------RIVKEDDSVLIYIFPGKNF---------------------
  59 KETLQ-------SMLEEEESVMVYRMDSGSYVERSVYGDDP-----------
  60 KSTLK------ELINETSDHIIFYS---------------------------
  61 EIKKI------RKILPVKANVRILLLSEKQYQNMLIISG-------------
  62 KKEIM------AIVNMKKDFVIIYSLRDGVKLNREIL---------------
  63 TAALK------TELDLSYDSIRIYRTRTPHLVETEWLGQ-------------