a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0355 NESG:AtR60, Agrobacterium tumefaciens, 288 res
- gi|75906863|ref|YP_321159.1|_26:299 Photosystem I assembly BtpA [Anabaena variabilis ATCC 29413]
- gi|75700588|gb|ABA20264.1| Photosystem I assembly BtpA [Anabaena variabilis ATCC 29413]
- gi|23125725|ref|ZP_00107646.1|_4:272 COG0434: Predicted TIM-barrel enzyme [Nostoc punctiforme PCC 73102]
- gi|24659916|ref|NP_648100.2|_4:272 CG8607-PA [Drosophila melanogaster]
- gi|23094003|gb|AAF50585.2| CG8607-PA [Drosophila melanogaster]
- gi|17130568|dbj|BAB73178.1|_4:272 biogenesis of thylakoid protein A [Nostoc sp. PCC 7120]
- gi|17228716|ref|NP_485264.1| biogenesis of thylakoid protein A [Nostoc sp. PCC 7120]
- gi|17945475|gb|AAL48791.1|_4:272 RE21901p [Drosophila melanogaster]
- gi|77390119|gb|ABA81303.1|_3:276 BtpA protein [Rhodobacter sphaeroides 2.4.1]
- gi|77465701|ref|YP_355204.1| BtpA protein [Rhodobacter sphaeroides 2.4.1]
- gi|83374424|ref|ZP_00919196.1|_3:276 Photosystem I assembly BtpA [Rhodobacter sphaeroides ATCC 17029]
- gi|83364141|gb|EAP67633.1| Photosystem I assembly BtpA [Rhodobacter sphaeroides ATCC 17029]
- gi|108869157|gb|EAT33382.1|_4:270 conserved hypothetical protein [Aedes aegypti]
- gi|67922738|ref|ZP_00516241.1|_5:267 BtpA [Crocosphaera watsonii WH 8501]
- gi|67855448|gb|EAM50704.1| BtpA [Crocosphaera watsonii WH 8501]
- gi|54641431|gb|EAL30181.1|_4:270 GA21203-PA [Drosophila pseudoobscura]
- gi|71675915|ref|ZP_00673658.1|_30:304 BtpA [Trichodesmium erythraeum IMS101]
- gi|71670776|gb|EAO27443.1| BtpA [Trichodesmium erythraeum IMS101]
- gi|16329576|ref|NP_440304.1|_5:268 BtpA [Synechocystis sp. PCC 6803]
- gi|1923214|gb|AAC45087.1| biogenesis of thylakoid protein A [Synechocystis sp. PCC 6803]
- gi|1652059|dbj|BAA16984.1| BtpA [Synechocystis sp. PCC 6803]
- gi|3913186|sp|P72966|BTPA_SYNY3 Photosystem I biogenesis protein btpA [Taxonomy]
- gi|17741432|gb|AAL43885.1|_3:275 conserved hypothetical protein [Agrobacterium tumefaciens str. C58]
- gi|15160345|gb|AAK90314.1| AGR_L_1705GMp [Agrobacterium tumefaciens str. C58]
- gi|17936780|ref|NP_533569.1| hypothetical protein Atu3069 [Agrobacterium tumefaciens str. C58]
- gi|15891857|ref|NP_357529.1| hypothetical protein AGR_L_1705GM [Agrobacterium tumefaciens str. C58]
- gi|91080101|ref|XP_966721.1|_8:266 PREDICTED: similar to CG8607-PA [Tribolium castaneum]
- gi|55240302|gb|EAA09691.2|_5:270 ENSANGP00000013225 [Anopheles gambiae str. PEST]
- gi|58385988|ref|XP_314354.2| ENSANGP00000013225 [Anopheles gambiae str. PEST]
- gi|62858435|ref|NP_001016400.1|_5:266 hypothetical protein LOC549154 [Xenopus tropicalis]
- gi|89273786|emb|CAJ81812.1| Novel protein similar to proteins found in invertebrates only thus far [Xenopus tropicalis]
- gi|16760265|ref|NP_455882.1|_3:266 hypothetical protein STY1449 [Salmonella enterica subsp. enterica serovar Typhi str. CT18]
- gi|29141968|ref|NP_805310.1| hypothetical protein t1524 [Salmonella enterica subsp. enterica serovar Typhi Ty2]
- gi|16502560|emb|CAD01710.1| conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]
- gi|29137597|gb|AAO69159.1| conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi Ty2]
- gi|25319333|pir||AE0667 conserved hypothetical protein STY1449 [imported] - Salmonella enterica subsp. enterica serovar Typhi (strain CT18) [Taxonomy]
- gi|81301322|ref|YP_401530.1|_9:273 Photosystem I assembly BtpA [Synechococcus elongatus PCC 7942]
- gi|81170203|gb|ABB58543.1| Photosystem I assembly BtpA [Synechococcus elongatus PCC 7942]
- gi|16764959|ref|NP_460574.1|_3:266 putative nucleoside triphosphatase [Salmonella typhimurium LT2]
- gi|16420140|gb|AAL20533.1| putative nucleoside triphosphatase [Salmonella typhimurium LT2]
- gi|56127699|gb|AAV77205.1|_3:266 conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150]
- gi|56413442|ref|YP_150517.1| hypothetical protein SPA1254 [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150]
- gi|66546417|ref|XP_396502.2|_1:254 PREDICTED: similar to ENSANGP00000013225 [Apis mellifera]
- gi|62180181|ref|YP_216598.1|_3:266 putative nucleoside triphosphatase [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67]
- gi|62127814|gb|AAX65517.1| putative nucleoside triphosphatase [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67]
- gi|106889126|ref|ZP_01356325.1|_9:278 Photosystem I assembly BtpA [Roseiflexus sp. RS-1]
- gi|106771644|gb|EAT28280.1| Photosystem I assembly BtpA [Roseiflexus sp. RS-1]
- gi|56751602|ref|YP_172303.1|_4:266 photosystem I biogenesis protein BtpA [Synechococcus elongatus PCC 6301]
- gi|56686561|dbj|BAD79783.1| photosystem I biogenesis protein BtpA [Synechococcus elongatus PCC 6301]
- gi|16132124|ref|NP_418723.1|_3:266 KpLE2 phage-like element; predicted nucleoside triphosphatase [Escherichia coli K12]
- gi|1790757|gb|AAC77259.1| KpLE2 phage-like element; predicted nucleoside triphosphatase [Escherichia coli K12]
- gi|89111013|ref|AP_004793.1| predicted nucleoside triphosphatase [Escherichia coli W3110]
- gi|732071|sp|P39364|SGCQ_ECOLI Putative sgc region protein sgcQ [Taxonomy]
- gi|85677044|dbj|BAE78294.1| predicted nucleoside triphosphatase [Escherichia coli W3110]
- gi|537144|gb|AAA97199.1| ORF_f268a [Escherichia coli]
- gi|22297723|ref|NP_680970.1|_4:265 photosystem I biogenesis protein [Thermosynechococcus elongatus BP-1]
- gi|22293900|dbj|BAC07732.1| photosystem I biogenesis protein [Thermosynechococcus elongatus BP-1]
- gi|3257626|dbj|BAA30309.1|_5:257 259aa long hypothetical protein [Pyrococcus horikoshii OT3]
- gi|3915508|sp|O58974|Y1209_PYRHO Hypothetical protein PH1209 [Taxonomy]
- gi|14591030|ref|NP_143105.1| hypothetical protein PH1209 [Pyrococcus horikoshii OT3]
- gi|68364080|ref|XP_683601.1|_1:250 PREDICTED: similar to GA21203-PA [Danio rerio]
- gi|86607233|ref|YP_475996.1|_4:279 photosystem I biogenesis protein BtpA [Synechococcus sp. JA-3-3Ab]
- gi|86555775|gb|ABD00733.1| photosystem I biogenesis protein BtpA [Synechococcus sp. JA-3-3Ab]
- gi|76260998|ref|ZP_00768622.1|_9:279 Photosystem I assembly BtpA [Chloroflexus aurantiacus J-10-fl]
- gi|76164117|gb|EAO58273.1| Photosystem I assembly BtpA [Chloroflexus aurantiacus J-10-fl]
- gi|35213215|dbj|BAC90587.1|_5:266 photosystem I biogenesis protein [Gloeobacter violaceus PCC 7421]
- gi|37522215|ref|NP_925592.1| photosystem I biogenesis protein [Gloeobacter violaceus PCC 7421]
- gi|5458484|emb|CAB49972.1|_6:257 Membrane protein, BtpA family [Pyrococcus abyssi GE5]
- gi|14548337|sp|Q9UZT4|Y1062_PYRAB Hypothetical protein PYRAB10620 [Taxonomy]
- gi|14521266|ref|NP_126741.1| hypothetical protein PAB1665 [Pyrococcus abyssi GE5]
- gi|90205678|ref|ZP_01208317.1|_55:322 Photosystem I assembly BtpA [Mycobacterium vanbaalenii PYR-1]
- gi|90195514|gb|EAS22280.1| Photosystem I assembly BtpA [Mycobacterium vanbaalenii PYR-1]
- gi|57160438|dbj|BAD86368.1|_6:257 hypothetical protein, conserved, BtpA family [Thermococcus kodakarensis KOD1]
- gi|57642114|ref|YP_184592.1| hypothetical protein TK2179 [Thermococcus kodakarensis KOD1]
- gi|74505304|sp|Q5JHL2|Y2179_PYRKO Hypothetical protein TK2179 [Taxonomy]
- gi|25019678|gb|AAL03925.2|_4:266 BtpA [Synechococcus sp. PCC 7942]
- gi|86609721|ref|YP_478483.1|_4:276 photosystem I biogenesis protein BtpA [Synechococcus sp. JA-2-3B'a(2-13)]
- gi|86558263|gb|ABD03220.1| photosystem I biogenesis protein BtpA [Synechococcus sp. JA-2-3B'a(2-13)]
- gi|67484448|ref|XP_657444.1|_6:264 conserved hypothetical protein [Entamoeba histolytica HM-1:IMSS]
- gi|56474673|gb|EAL52034.1| conserved hypothetical protein [Entamoeba histolytica HM-1:IMSS]
- gi|92907378|ref|ZP_01276158.1|_3:267 Photosystem I assembly BtpA [Mycobacterium sp. JLS]
- gi|92435678|gb|EAS95009.1| Photosystem I assembly BtpA [Mycobacterium sp. JLS]
- gi|108799390|ref|YP_639587.1|_3:267 photosystem I assembly BtpA [Mycobacterium sp. MCS]
- gi|108769809|gb|ABG08531.1| photosystem I assembly BtpA [Mycobacterium sp. MCS]
- gi|92916709|ref|ZP_01285327.1| Photosystem I assembly BtpA [Mycobacterium sp. KMS]
- gi|92439156|gb|EAS97005.1| Photosystem I assembly BtpA [Mycobacterium sp. KMS]
- gi|1591754|gb|AAB99116.1|_7:256 conserved hypothetical protein [Methanocaldococcus jannaschii DSM 2661]
- gi|3915417|sp|Q58515|Y1115_METJA Hypothetical protein MJ1115 [Taxonomy]
- gi|15669302|ref|NP_248107.1| hypothetical protein MJ1115 [Methanocaldococcus jannaschii DSM 2661]
- gi|14027124|dbj|BAB54078.1|_15:277 mll7660 [Mesorhizobium loti MAFF303099]
- gi|13476363|ref|NP_107933.1| hypothetical protein mll7660 [Mesorhizobium loti MAFF303099]
- gi|71366562|ref|ZP_00657103.1|_3:266 BtpA [Nocardioides sp. JS614]
- gi|71157771|gb|EAO08157.1| BtpA [Nocardioides sp. JS614]
- gi|89341173|ref|ZP_01193418.1|_5:268 Photosystem I assembly BtpA [Mycobacterium flavescens PYR-GCK]
- gi|89318804|gb|EAS10298.1| Photosystem I assembly BtpA [Mycobacterium flavescens PYR-GCK]
- gi|92082464|emb|CAJ90501.1|_13:273 Hypothetical protein F13E9.13 [Caenorhabditis elegans]
- gi|33359517|ref|NP_578589.2|_9:262 btpA family protein [Pyrococcus furiosus DSM 3638]
- gi|87301772|ref|ZP_01084606.1|_7:267 Photosystem I assembly BtpA [Synechococcus sp. WH 5701]
- gi|87283340|gb|EAQ75295.1| Photosystem I assembly BtpA [Synechococcus sp. WH 5701]
- gi|18892895|gb|AAL80984.1|_7:257 btpA family protein [Pyrococcus furiosus DSM 3638]
- gi|74536547|sp|Q8U2H5|Y860_PYRFU Hypothetical protein PF0860 [Taxonomy]
- gi|39581824|emb|CAE60717.1|_13:275 Hypothetical protein CBG04389 [Caenorhabditis briggsae]
- gi|71368323|ref|ZP_00658825.1|_3:267 BtpA [Nocardioides sp. JS614]
- gi|71155949|gb|EAO06374.1| BtpA [Nocardioides sp. JS614]
- gi|50753761|ref|XP_414122.1|_118:359 PREDICTED: similar to RE21901p [Gallus gallus]
- gi|89054603|ref|YP_510054.1|_5:263 photosystem I assembly BtpA [Jannaschia sp. CCS1]
- gi|88864152|gb|ABD55029.1| photosystem I assembly BtpA [Jannaschia sp. CCS1]
- gi|10581912|gb|AAG20579.1|_7:264 Vng2518c [Halobacterium sp. NRC-1]
- gi|15791275|ref|NP_281099.1| hypothetical protein VNG2518C [Halobacterium sp. NRC-1]
- gi|17539808|ref|NP_502019.1|_51:294 F13E9.3 [Caenorhabditis elegans]
- gi|3915575|sp|Q19408|YSMK_CAEEL Hypothetical protein F13E9.3, mitochondrial precursor [Taxonomy]
- gi|19888135|gb|AAM02676.1|_14:263 Predicted TIM-barrel enzyme [Methanopyrus kandleri AV19]
- gi|20094899|ref|NP_614746.1| Predicted TIM-barrel enzyme [Methanopyrus kandleri AV19]
- gi|3915360|sp|O29828|Y419_ARCFU_4:242 Hypothetical protein AF_0419 [Taxonomy]
- gi|11498031|ref|NP_069255.1| hypothetical protein AF0419 [Archaeoglobus fulgidus DSM 4304]
- gi|2650208|gb|AAB90814.1| conserved hypothetical protein [Archaeoglobus fulgidus DSM 4304]
- gi|83592602|ref|YP_426354.1|_6:262 Photosystem I assembly BtpA [Rhodospirillum rubrum ATCC 11170]
- gi|83575516|gb|ABC22067.1| Photosystem I assembly BtpA [Rhodospirillum rubrum ATCC 11170]
- gi|90420082|ref|ZP_01227990.1|_4:264 btpA family protein [Aurantimonas sp. SI85-9A1]
- gi|90335416|gb|EAS49166.1| btpA family protein [Aurantimonas sp. SI85-9A1]
- gi|5106152|dbj|BAA81463.1|_4:280 287aa long hypothetical protein [Aeropyrum pernix K1]
- gi|14602072|ref|NP_148618.1| hypothetical protein APE2448 [Aeropyrum pernix K1]
- gi|89068451|ref|ZP_01155848.1|_5:264 hypothetical protein OG2516_12934 [Oceanicola granulosus HTCC2516]
- gi|89045870|gb|EAR51930.1| hypothetical protein OG2516_12934 [Oceanicola granulosus HTCC2516]
- gi|15623271|dbj|BAB67259.1|_3:246 250aa long conserved hypothetical protein [Sulfolobus tokodaii str. 7]
- gi|15922481|ref|NP_378150.1| hypothetical protein ST2156 [Sulfolobus tokodaii str. 7]
- gi|72015186|ref|XP_784983.1|_9:209 PREDICTED: similar to CG8607-PA [Strongylocentrotus purpuratus]
- gi|108869158|gb|EAT33383.1|_7:188 conserved hypothetical protein [Aedes aegypti]
- gi|90575511|ref|ZP_01231994.1|_6:244 hypothetical protein CdifQ_02001070 [Clostridium difficile QCD-32g58]
- gi|108869159|gb|EAT33384.1|_5:176 conserved hypothetical protein [Aedes aegypti]
- gi|18161736|gb|AAL64997.1|_2:230 conserved hypothetical protein [Pyrobaculum aerophilum str. IM2]
- gi|18314148|ref|NP_560815.1| hypothetical protein PAE3553 [Pyrobaculum aerophilum str. IM2]
- gi|29344958|gb|AAO82715.1|_6:245 conserved hypothetical protein [Enterococcus faecalis V583]
- gi|29377491|ref|NP_816645.1| hypothetical protein EF3032 [Enterococcus faecalis V583]
- gi|55240303|gb|EAL40411.1|_3:179 ENSANGP00000029086 [Anopheles gambiae str. PEST]
- gi|57927024|ref|XP_558281.1| ENSANGP00000029086 [Anopheles gambiae str. PEST]
- gi|50787069|ref|XP_423506.1|_2:91 PREDICTED: similar to CG8607-PA, partial [Gallus gallus]
- gi|136261|sp|P26920|TRPA_METTM_34:232 Tryptophan synthase alpha chain [Taxonomy]
- gi|99115|pir||D40362 trpA protein - Methanobacterium thermoautotrophicum (strain Marburg) [Taxonomy]
- gi|149750|gb|AAA73033.1| tryptophan synthase alpha-subunit [Taxonomy]
- gi|83319533|ref|YP_424451.1|_70:220 copper homeostasis protein CutC, putative [Mycoplasma capricolum subsp. capricolum ATCC 27343]
- gi|83283419|gb|ABC01351.1| copper homeostasis protein CutC, putative [Mycoplasma capricolum subsp. capricolum ATCC 27343]
- gi|57242709|ref|ZP_00370646.1|_183:243 tryptophan synthase, alpha subunit [Campylobacter upsaliensis RM3195]
- gi|57016638|gb|EAL53422.1| tryptophan synthase, alpha subunit [Campylobacter upsaliensis RM3195]
- gi|78498418|gb|ABB44958.1|_168:215 Tryptophan synthase [Thiomicrospira denitrificans ATCC 33889]
- gi|78777878|ref|YP_394193.1| Tryptophan synthase [Thiomicrospira denitrificans ATCC 33889]

              10        20        30              40        50        6
              |         |         |               |         |         
   1 MQTISDNAANAIQEIFGRSKALIGMIHCPAFPGAPRYR.N.....ASMDAIYDACMRDAERLIEG
   2 -------KDVDLYQLFKTRTPIIGVVHLLPLPTSPRWG.G.....-SLKAVIDRAEQEATALASG
   3 ------------YQLFKTRSPIIGVVHLLPLPTSPRWG.G.....-SLKAVIDRAEQEAAALASG
   4 ----------FLKVFKQQTCKIIGMIHVDALPGTPRYA.G.....-NWKQTIENAIYEANLYKKH
   5 ------------YQLFKTRTPIIGVVHLLPLPTSPRWG.G.....-SLKAVIDRAEQEATALASG
   6 ----------FLKVFKQQTCKIIGMIHVDALPGTPRYA.S.....-NWKQTIENAIYEASLYKKH
   7 --LISDRTSGAIHEIFGRDKALIGMIHCPPFPGAPRYR.G.....ETMDTIVDACLRDAERLVAG
   8 --LISDRTSGAIHEIFGRDKALIGMIHCPPFPGAPRYR.G.....ETMDTIVDACLRDAERLVAG
   9 ------------KKLFPYRFPIIGMIHLDALPGTPLYK.G.....-NFDAIIAKAVHEAELYANS
  10 -------------QIFNTTNPVIGVVHLLPLPTSPRWG.G.....-SLKAVIERAEQEATALAAG
  11 ----------FLKIFGQQKCKVIGMIHVDALPGTPRYA.G.....-HWKETIEKAIYEANLYKRH
  12 --------PVDLKQIFKTRNPIIGVVHLQPLPTSPLWG.G.....-DLQAIISRAEREATALVSG
  13 -------------QTFQTHNPVIGVVHLLPLPTSARWG.G.....-NLTAVIERAEQEATALAAG
  14 --TISDNAANAIQEIFGRSKALIGMIHCPAFPGAPRYR.N.....ASMDAIYDACMRDAERLIEG
  15 --------------FHTTKCAVVGMVHVGALPGTPLCN.K.....-SVDSLVFKACKEAEMYLKY
  16 ------------CSLFAKPFPIIGMIHVGALPGTPLYK.G.....-HMNKLISEAQAEANIYRKC
  17 ------------QLFGTVKPIVIGMVHVKALPGTPGSR.L.....-PVAQIIEEACHEAEIYKNA
  18 ----------WLKEVIGTEKAVIAMCHLRALPGDPGFDtR.....KGMNWVIDRAHDDLMALQNG
  19 ----------DLHRIFGTTTPVIGVVHLQPLPTAARWG.G.....-NLRAVIERAEQEATALAAG
  20 ----------WLKEVIGTEKAVIAMCHLRALPGDPGFDtR.....KGMNWVIDRAHDDLMALQNG
  21 ----------WLKEVIGTEKAVIAMCHLRALPGDPGFDtK.....KGMNWVIDRAHDDLMALQNG
  22 ------------------------MVHVGALPGTPSYN.G.....-NINQIISNAIKETIIYRDC
  23 ----------WLKEVIGTEKAVIAMCHLRALPGDPGFDtR.....KGMNWVIDRAHDDLMALQNG
  24 ---LDALRIRDLSAIFRTPKPIIGMVHLWPLPGAPGYT.G.....YGMQTIIDQALYDAHTLAEG
  25 ------------HRIFGTTTPVIGVVHLQPLPTAARWG.G.....-NLRAVIERAEQEATALAAG
  26 ----------WLKEVIGTEKAVIAMCHLRALPGDPSFDaQ.....LGMNWVIDKAWDDLMALQNG
  27 ------------RTLFHTATPVIGVVHLLPLPTSARWG.G.....-SLKAVIDRAEQEATALASG
  28 ------------------NKPLIGVVHLPPLPGSPGYK.G.....-ELDEVIDRAISDAAKYQEA
  29 ------------------------MIHVRALPGTPLNR.L.....-TISDIKEEACREAEIYYNA
  30 -----------LQHLFKTPHPVIGVVHLLPLPTSPRWG.G.....-DLEWVIAQAEQAATALAAG
  31 ---LDRLRLRDLREMFRTAKPIIGMVHCWPLPGAPGYT.G.....YGMQTIIEHAIRDAEALAEG
  32 ------------VDLFLTAKPIIGVVHLLPLPTSPRWA.G.....-SLDAVMARAEQEATALATG
  33 -------------------KPLIGVVHLLPLPGSPGYR.G.....-SIEEILDRAISDAAKYQEA
  34 -------TTNWLDEVFGVAKPVIAMLHLSALPGDPGYD.Sa....GGIAAVVNRARTELEALQGG
  35 -------------------KPLIGMVHLKPLPGSYLYN.G.....-DFDSVIEAALRDAVTLEEA
  36 ------------HRIFGTTTPVIGVVHLQPLPTAARWG.G.....-NLRAVIERAEQEATALAAG
  37 -----------LQHLFKTPHPVIGVVHLLPLPTSPRWG.G.....-DLEWVIAQAEQAATALAAG
  38 ---------------FEGHNRIIGMVHVHALPGTPNYS.Sta...GRCRAIIEKAVEEATVYQQC
  39 ---------NWLDEVFAVQKPVIAMLHLSALPGDPGYD.Sa....AGIRAVVDRAKGELAALRDG
  40 ---------NWLDEVFAVQKPVIAMLHLSALPGDPGYD.Sa....AGIRAVVDRAKGELAALRDG
  41 ------------------KKPLIGMVHLKPLPGSYHYN.D.....-NFDDIVDFAIKEAKKLEEA
  42 --------DDALQSIFGRKKVVIGVVHLAPLPGAPRYD.G.....EAVEAIYQRGLDDAKAYLDG
  43 ---------NWLHEVFDVPKPIVGMCHLPALPGDPGYDaA.....GGMDKILAHARQEIDALQTG
  44 ----------WLDEVFNVTKPVIAMLHLSALPGDPGYD.Sa....GGIAAVVNRARTELEALQSG
  45 ----------------SSRPLVFGMIHVPALPGTPSNT.L.....-PMSAILKKVRKEADVYFKN
  46 --------------LDFSKKPLIGVVHLKPLPGSPRYG.G.....-DFEEVIEWAIRDAKTYEEA
  47 ----------RWRELFPQPCPLIGVIHLGPLPGSPGWA.G.....-DLGSLEATALADAEAYLSG
  48 -----------------SKKPLIGVVHLKPLPGSPRYG.G.....-DFEEVIEWAIRDAKTYEEA
  49 ----------------SSRPLVFGMIHVPALPGTPSNT.L.....-PMSAILKKVRKEADVYFKN
  50 ----------WLKETFGVDRPIIAMLHLKPLPGDPHYDaT.....TGMAAVLRAAGEDLRALQDG
  51 --------------------------------GTPRSS.-.....FPLAQIIDQACQEAEAYKDA
  52 ------------RDVFGTPKPVIAMVHLGAMPGTPLHDaD.....AGLEGLVAAAAADLSALQAA
  53 -----------------ADTPVVGMVHLSPLPGAPGYD.D.....GNRPAIRDAALRDASRLEAG
  54 ----------------------------------TPSN.T.....LPMSAILKKVRKEADVYFKN
  55 --------------------EVVGVVHLPPLPGSPRAK.S.....--IEEVVERARRDAARLEDG
  56 --------------------TVIGVVHLLPLPGSPEHT.D.....--LSAVIDKAVKDARAIEEG
  57 --------------LGPRKKAVIAMAHIGALPGTPLYDaD.....GGMMKLIDDVVGDIEKLQKG
  58 -----------FRTLFGERKPVIAMVHLLPLPGTPLYDpA.....GGIEAIVEAARRDLQALQAA
  59 ---------------FQRCKPLLGVVHLPPLPGSTGYK.Ar10kvWSLEEIIEYAVSEASVYEDA
  60 -----------LDMLARGGRPVIGMVQLPPLAGGANYG.G.....APVGEVLEAALEEARVLADN
  61 ---------------------LIGVVHLPPLPGSFFYK.G.....-EFEEIVDFAINESKKLEVG
  62 ---------------GHNHGVVIGMLHVPALPGTPCHN.M.....-PLQAIIKKVCEEARGYMRA
  63 --------------------------------------.-.....--------------------
  64 -----------ILSVFKSKKPIIAMIHLK---------.G.....DTPEDIFERAKKEITIFEEN
  65 --------------------------------------.-.....--------------------
  66 ---------------------IIGVLHLLPIDDPEFFN.H.....---------AVRNARRLEEA
  67 ----------DFLELFAVEKPIIGVIHLK---------.G.....KTDQEIQERAKKEIQIYSEH
  68 --------------------------------------.-.....----KLISEAQAEANIYRKC
  69 --------------------------------------.-.....--------------------
  70 --------------------------------------.-.....--------------RTLVDA
  71 --------------------------------------.-.....--------------------
  72 --------------------------------------.-.....--------------------
  73 --------------------------------------.-.....--------------------


      0        70         80             90            100       110   
     |         |          |              |              |         |   
   1 GMHGLIVENHGDVPFSKP.DDIGPETSAFMS.....VVTDRIVRTA.....GVPVGINVLANAPI
   2 GVDGIIVENFFDAPFTKN.-QVDPAVVSAMT.....VVVQRIQNLV.....TLPIGLNVLRNDGK
   3 GVDGLIVENFFDAPFTKN.-QVDPVVVSAMT.....IVVQRIQNLV.....TLPIGLNVLRNDGK
   4 QLDAVLIENMHDIPYVPE.RLLGAEIVACMT.....RLGRAVREVIpq...EIPCGVQVLACGNK
   5 GVNGIIVENFFDAPFTKN.-QVDPAVVSAMT.....VVVQRIQNLV.....TLPVGLNVLRNDGK
   6 QLDAVLIENMHDIPYVPE.RLLGAEIVACMT.....RLGRAVREVIpq...EIPCGVQVLACGNK
   7 GLHGLVVENHGDIPFSKP.DDIGPETAACLG.....VVTDRIRRAF.....GVPLGINVLANAPL
   8 GLHGLVIENHGDIPFSKP.EDIGPETAACLG.....VVTDRIRRAF.....GVPLGINVLANAPL
   9 LIDAVMIENMHDVPYVQR.QHFGPETVACMT.....KIATLVRGAVge...NTRCGIQVLACGNE
  10 GVDGIIVENFFDAPFTKE.-KVDPVVISAMT.....LIVDRIKNLV.....VVPVGINLLRNDSV
  11 QLDAVLIENMHDIPYVPE.RLLGAEITACMT.....RLGQAVRDVIpk...EIPCGVQVLACGNK
  12 GVDGIIVENFFDAPFVKD.-QVDPAVVSAMT.....LLVQKIMNLV.....SLPIGINVLRNDGQ
  13 GVDGIIVENFFDAPFPKQ.-RVDPAVVSAMT.....LIVDRLQNLV.....VAPVGINVLRNDAH
  14 GMHGLIVENHGDVPFSKP.DDIGPETSAFMS.....VVTDRIVRTA.....GVPVGINVLANAPI
  15 GLDSILVENMHDVPYIQS.KYFTPETVATMT.....RVCTEIRKIApg...TVPCGVQVLACGNL
  16 GVDGVLVENMHDIPYIRPrDGLGPEITSAMT.....RVTLAVRETIp....DIPCGVQILAGCNR
  17 GIDGIMVENMHDIPYTFN.--TGPEITATMA.....TICTAVKQACp....HLPLGVQILSCANN
  18 GVDAVMFSNEFSLPYLTK.--VRPETTAAMA.....RIIGQLMSEI.....RVPFGVNVLW-DPV
  19 GVNGIIVENFFDAPFPKN.-RVDPAVVSAMT.....LVVERLQNLV.....TIPLGLNVLRNDAH
  20 GVDAVMFSNEFSLPYLTK.--VRPETTAAMA.....RIIGQLMSEI.....RVPFGVNVLW-DPV
  21 GVDAVMFSNEFSLPYLTK.--VRPETTTAMA.....RIIGQLMSEI.....RVPFGVNVLW-DPV
  22 NIDGILVENMHDNPYMRP.EHLTPETTAMMT.....RICTEIKQVLpk...NIPCGIQILAGCNK
  23 GVDAVMFSNEFSLPYLTK.--VRPETTTAMA.....RIIGQLMSKI.....RVPFGVNVLW-DPV
  24 GVDGVIVENMWDIPFRAG.PNVQPESIAAHA.....VAAHAVRRAI.....DLPLGINLVHNGGV
  25 GVNGIIVENFFDAPFPKN.-RVDPAVVSAMT.....LVVERLQNLV.....TIPLGLNVLRNDAH
  26 GVDAVMFSNEFSLPYLTK.--VRPETTAAMA.....RIIGQLMSDI.....RIPFGVNVLW-DPV
  27 GVNAIIVENFFDAPFSKD.-RVDAAVVSAMT.....LVVQRLKNLV.....ALPIGLNVLRNDAF
  28 GFDAIILENYGDFPYSKT.--VGKETVSAFS.....VVANEVKREI.....ALPLGINVLRNDCI
  29 GLDGLIIENMHDIPYTLD.--VGPEVCACMT.....AVCTAVRGLYp....SWPLGVQILSAANH
  30 GVDGILVENFYDAPFAKE.-RVDAAVVSAMT.....VVVQRIKMLV.....SLPIGINVLRNDGY
  31 GCDGLIVENMWDIPFRAG.PHVPPESIAAQA.....VVAHAVRQAVp....ELPLGINLVHNGGV
  32 GVDALIVENYYDAPFVPG.-RVDPAVVAAMS.....LVVKRIIHLV.....PVPVGVNVLRNDAH
  33 GFDAIILENYGDFPYSKT.--ISKETLASFA.....VIAKEVGREI.....SIPIGINVLRNDCV
  34 GVDGVMISNEFSLPYLTK.--TEPITAITMA.....RIIGELLPDI.....SVPFGVNVLW-DGR
  35 GFDAVMVENFGDVPFPKY.--ADKTTVASLA.....VVAKAIRDEV.....SLPLGVNVLRNDGI
  36 GVNGIIVENFFDAPFPKN.-RVDPAVVSAMT.....LVVERLQNLV.....TIPLGLNVLRNDAH
  37 GVDGILVENFYDAPFAKD.-RVDAAVVSAMT.....VIVQRLKTLV.....SLPVGINVLRNDGC
  38 GLDTIMIENMHDVPYLNS.-TAGPEITSAMS.....IVGYEIKRQL.....NLRVGVQILAAANK
  39 GVDGVMISNEFSLPYLTK.--TEPITAITMA.....RIIGELLPDL.....TLPYGVNVLW-DGR
  40 GVDGVMISNEFSLPYLTK.--TEPITAITMA.....RIIGELLPDL.....TLPYGVNVLW-DGR
  41 GFDAVMIENFGDAPFKKE.--ADKITIASMA.....VIAKAIKEEV.....SLPLGINILRNDAI
  42 GCDGVIVENHGDVPFAKP.DDIGPETSAYMS.....VVSDRIRREI.....GRPIGINVLANASI
  43 GVDGILISNEFSLPYLTR.--TEPITAITMA.....RTIGELISEI.....QVPFGVNVLW-DGV
  44 GVDAVMISNEFSLPYLTK.--TEPITAITMA.....RIIGELLPDI.....SVPYGVNVLW-DAR
  45 GVDGVIVENMHDVPYVKP.-PASPEIVSSMA.....LASDQLVKSRdahhpAALTGIQILAAANR
  46 GFDGIIVENFGDSPFSKT.--LPREVIPAFT.....VVAKAVKKEV.....SLPLGINALRNDCI
  47 GADGLIVENFGDVPFWRG.-SVPPETVAAMT.....RLALAVVRAT.....ERPVGINVLRNDAL
  48 GFDGIIVENFGDSPFSKT.--LPREVIPAFT.....VVAKAVKKEV.....SLPLGINALRNDCI
  49 GVDGVIVENMHDVPYVKP.-PANPEIVSAMS.....LASDQLVKSRdahhpGALTGIQILAAANR
  50 GVDAVMFSNEFSLPYLTK.--TEPITAISMA.....RIIGELASDI.....RVPFGVNVLW-DGP
  51 GVDGLIVENMHDRPYTLC.--PGPEVTAAMT.....AVGAAVRRLCp....HLALGVQVLCAANQ
  52 GVDAVMFGNENDRPYEFA.--VDTASTATMA.....YVIGQLRGQI.....TVPFGVNVLW-DPD
  53 GVDALLVENFGDAPFYAD.-DVPKHVVASMA.....ALVRDITREA.....EVPVGVNVLRNDAE
  54 GVDGVIVENMHDVPYVKP.-PASPEIVSSMA.....LASDQLVKSRdahhpAALTGIQILAAANR
  55 GVDAVLVENFGDTPYYPD.-DVPKITVACMT.....RAVAEVVDTV.....SVPVGVNVLRNDGV
  56 GADALILENYGDKPFLKE.--VGKETVAAMT.....VIACEVKRDV.....SIGLGINVLRNDAV
  57 GVHAIMFGNENDRPYQFE.--APIASVAAMT.....AIISAVRPML.....SVPFGVNYLW-DPA
  58 DVDAVMFGNENDRPYELK.--VDTASTATMA.....QVIGRLRPEI.....EKPFGVNVLW-DPM
  59 GFDGVILENYGDTPYPKT.--PGPLQVSAMT.....RIVREVSSAV.....GIPVGVNMLRNGSV
  60 GIDGLMVQNLGDIPVAHA.--ATAAQVAWMT.....RATVEIGRIA.....ACPVGLNMLENDVD
  61 GFDAVILENFNDKPFRKK.--VRVETAIAMS.....IIAREVKKST.....SLLVGINLLRNSAY
  62 GITGLMLENMHDVPYIQP.NHVGPEITASMT.....AVSSAVRQEYp....DIPLGVQVLSAANK
  63 ------------------.------------.....-------DNI.....SVPKQWHVLACGNE
  64 GVDGIMLENYYGNYYDLE.RILEYVSKA---.....--------NL.....SIPYGVNCLNVDTM
  65 ------------------.------------.....----------.....-------VLACGNE
  66 GADAIIVENYYDTPFKPY.--ADFPRAVAVA.....AAVRDVVREV.....SIPVGVNLLRNACR
  67 GVDAILMENYYGDYVQLE.KALQYVTSL---.....--------DL.....PIPIGVNVLNVDPL
  68 GVDGVLVENMHDIPYIRPrDGLGPEITSAMT.....RVTLAVRETIp....DIPCGVQILAGCNR
  69 ------------------.------------.....----------.....--------------
  70 GADALEIGFPFSDPIADG.TSVQEADLRALNsg9cfRLIERIREFT.....SVPVGLLVYYNLIY
  71 ------------------.---ELIKQLEMI.....SVVQKLPNVH.....GIVIG--ALNND--
  72 ------------------.------------.....----------.....--------------
  73 ------------------.------------.....----------.....--------------


          120          130       140        150          160       170 
           |            |         |          |            |         | 
   1 PAFAIAKAGGAKFIRV...NQWANAYVANEGFME.GRAAEAMRYRSLLR...AEHIKVFADSHVK
   2 SAMAIASCVRAQFIRV...NVLTGVMATDQGLIE.GEAHELLRYRRELG...-SDVQILADVLVK
   3 SAMAIASCVQAQFIRV...NVLTGVMATDQGLIE.GEAHHLLRYRRELG...-CDVKILADVLVK
   4 QALAIAKASQLQFIRA...EGFVFGHVADEGFTD.ACAGDLLRYRKLID...AEDVLIFTDLKKK
   5 SAMAIASCVRAQFIRV...NVLTGVMATDQGLIE.GEAHELLRYRRELG...-SDVQILADVLVK
   6 QALAIARASQLQFIRA...EGFVFGHVADEGFTD.ACAGDLLRYRKLID...AEDVLIFTDLKKK
   7 PALAAAVAGGALFIRV...NQWANAYVANEGFME.GRAAEAMRYRSLLR...AEHVRIFADSHVK
   8 PALAAAVAGGALFIRV...NQWANAYVANEGFME.GRAAEAMRYRSLLR...AEHVRIFADSHVK
   9 EALAVAKACNFDFIRA...EGFVFSHVADEGFTD.ANAGQLLRYRRNID...AEHIQIFTDIKKK
  10 GAMAIASTINAQFIRV...NVLTGIMATDQGLIE.GNAYELLRYRRQLD...A-EVAILADVLVK
  11 QALAIAKASQLQFIRS...EGFVFGHVADEGYTD.ACAGDLLRYRKLID...AEDVLIFTDLKKK
  12 SAMGIAYCVEAQFIRV...NVLTGVMATDQGLIE.GIAHQLLRYRRELG...-TDVKILADVLVK
  13 SALAIASCVGAKFIRV...NVLTGVMATDQGLIE.GNAHELLRYRRELS...-SDVAILADVLVK
  14 PAFAIAKAGGAKFIRV...NQWANAYVANEGFME.GRAAEAMRYRSLLR...AEHIKVFADSHVK
  15 EALAVAKACNFDFIRA...EGFVFGHVADEGYTD.ANAGLILRYRRQIQ...AENVLILADIKKK
  16 EALAVAKVCQLQFIRA...EGFVFGHMADEGFTD.ACAGSLLRYRKQID...AEDVLVLTDIKKK
  17 QALAVALAAGLDFIRA...EGYVFSHVADEGFVN.ACAGDLLRYRKAIG...AEHIQIFADIKKK
  18 ASFDLAMATDAKFIR-...EIFTGAYASDFGVWD.TNVGETIRHQHRIG...AGHVKTLFNIVPE
  19 SALAIASCTGAAFIRV...NVLTGVMATDQGLIE.GEAHQLLRYRRELG...-SSVQILADVLVK
  20 ASFDLAMATDAKFIR-...EIFTGAYASDFGVWD.TNVGETIRHQHRIG...AGHVKTLFNIVPE
  21 ASFDLAMATDAKFIR-...EIFTGAYASDFGVWD.TNVGETIRHQHRIG...AGHVKTLFNIVPE
  22 EAIAVAKATNFQFIRA...EGFVFSHIADEGFTD.ACAGSLLRYRKQID...ADDILIFADIKKK
  23 ASFDLAMATDAKFIR-...EIFTGAYASDFGVWD.TNVGETIRHQHRIG...AGHVKTLFNIVPE
  24 ALLGIALAAGASFIRV...CMFTGAGVWDTGAWDeGCAADLMRRRKELH...AEHINIFADVDKK
  25 SALAIASCTGAAFIRV...NVLTGVMATDQGLIE.GEAHQLLRYRRELG...-SSVQILADVLVK
  26 ASFDLAMATGAKFIR-...EIFTGAYASDFGVWD.TNVGETIRHQHRIG...AGEVKTLFNIVPE
  27 SGLAIAACTGAQFIRV...NVLTGVMATDQGLIE.GPAHQLLRYRRELG...-QDIKIFADVMVK
  28 AAYSIAYSIKADFIRV...NVLTGVAFTDQGIVE.GCARELAELRTRLP...-SRIDVLADVHVK
  29 SALAVALASGLDFIRA...EGFVFSHVADEGLLN.ACAGELLRYRKRIG...AEHVQIFTDIKKK
  30 SALAIAACVGAQFIRV...NVLCGAMVTDQGIIE.GNAHRLLRYRRELG...A-DIKIFADVLVK
  31 ALLGIAIAAGASFIRV...CMFTGAGVWDAGSWDeGCAADLMRRRKELH...AESIKIFADVDKK
  32 AALAVAACTGAQFIRV...NILTGTMATDQGIIQ.GEAHSVLRYRRELG...A-ETRIFADVLVK
  33 ASYSIAYSVRADFIRV...NVLTGVAFTDQGIIE.GCARELAELRARLP...-SRIKVLADVHVK
  34 ASIDLAVATGAKWVR-...EIFTGVYASDFGLWD.TNVGEVARHRARVG...GADVKLLFNIVPE
  35 AAYSIAYAVKADFIRV...NVLSGVAYTDQGIIE.GIAHELAMLRKRLP...-SEIKVFADVHVK
  36 SALAIASCTGAAFIRV...NVLTGVMATDQGLIE.GEAHQLLRYRRELG...-SSVQILADVLVK
  37 SALAIAACVGAQFIRV...NVLCGAMVTDQGIIE.GNAYRLLRYRRELG...A-NIKIFADVLVK
  38 QAMAAAFCSGCDFIRA...EGFVFGHVADEGYID.SNAGELLRYRKMIG...AEDVLVFTDIKKK
  39 ASIDLAVATGAQWVR-...EIFTGVYASDFGLWD.TNVGAVARHRHRIG...GAGVKLLFNIVPE
  40 ASIDLAVATGAQWVR-...EIFTGVYASDFGLWD.TNVGAVARHRHRIG...GAGVKLLFNIVPE
  41 GAYSIAYVVKADFIRV...NVLSGVAFTDQGIIE.GKAYELAKLKKLLP...-SKIKVFADVHVK
  42 PALSIASASGASFVRV...NQWANAYVANEGFIE.GEAARAMRFRARLR...ANGIRIFADAHVK
  43 ASIDLAMATGAAFVR-...EVFTGVYASDFGMWN.TDVGRAARHRAQVG...AGGVRLLYNIVPE
  44 ASIDLAVATGAKFVR-...EIFTGVYASDFGLWD.TNVGEVARHRARVG...GAGVKLLYNIVPE
  45 EALAVAYTTGMDFIRA...EGFVYSHVADEGWID.GCAGGLLRYRSSLK...AENIAIFTDIKKK
  46 VAYSIAHAVGGSFIRV...NVLTGVAFTDQGIIE.GCARELWNVKRIIG...-GDILTLADVHVK
  47 AALAIAQASGARFLRV...NVLSGATVTDQGLIE.GVAAELLRRRRLLG...AESVRILADVLVK
  48 VAYSIAHAVGGSFIRV...NVLTGVAFTDQGIIE.GCARELWNVKRIIG...-GDILTLADVHVK
  49 EAIGVAYTTGLDFIRA...EGFVYSHVADEGWID.GCAGGLLRYRSSLK...ADHVAVFTDIKKK
  50 ASIDLAAATGAQFVR-...EIFSGVYASDFGLWN.TNVGLSARRQRQHD...AMGVRLLFNIVPE
  51 QATAVALAAGLDFIRV...EGFVFSHVADEGIIN.ACAGDLLRYRKLVG...AENIQIFADIKKK
  52 STIALAAATGAQFCR-...EIFTGTYASDMGVWA.PDAGRALRYRKRLG...RDDLAMLYNVSAE
  53 AAVSIAAAADADFVRV...NVHTGARLTDQGVVG.GQAAETVRLRDRLD...AAEVSMLADIDVK
  54 EALAVAYTTGMDFIRA...EGFVYSHVADEGWID.GCAGGLLRYRSSLK...AENIAIFTDIKKK
  55 AAVDVCAATGASFIRV...NAYVEAVATDQGVLQ.PVAHMVWREIDRLG...V-DVEVYADIRVK
  56 AALAIAKAVNADFVRV...NQLFFTSVSPEGILE.GKAGEVMRYKKLVD...C-RAMIFADIAVK
  57 ASVAIAVATGASFAR-...EIFTGVFASDMGVWS.PNAAEALRLRRNLH...RPDLKLLFNINAE
  58 ASVALAAATGAAFLR-...EILTGTYASDMGPWT.PDAGAAMRYRDRLR...RPDLAMFANVCAE
  59 EALASAYSGGGSFIRV...NSLCETRLSPEGILE.PDAARLAKSLALLGileERRIEILADVDVK
  60 AMFAVASAAGADFVRI...KVFVGAMVTPFGLEQ.GRAHAAARARRGCG...GGDIAILADVHDR
  61 EAASIASLTG-DFIRV...NALCETISSPEGIIE.PASVEVQEVLYYTK...-RKISILADINVK
  62 QALAVALAAGLDFIRA...EGFVFSHVGDEGFQN.ACAGELLRYRKQIG...ADHIKILTDIKKK
  63 EALAVAKACNFDFIRA...EGFVFSHVADEGFTD.ANAGQLLRYRRNID...AEHIQIFTDIKKK
  64 -GFELATKYNASYIQV...DSVVGHVKPRDEATL.EEFFKLQRSK----...-CPAYLIGGVRFK
  65 EALAVAKACNFDFIRA...EGFVFSHVADEGFTD.ANAGQLLRYRRNID...AEHIQIFTDIKKK
  66 KAAVIARYAGGRFIRC...NAYTDVVLTESGLLL.PQAPYI--------...-KGVKVLADVHVK
  67 -GFHLANKYHLQFLQI...DSVVGHVKPRDEASL.QAFFDLYRAK----...-TTAKLIGGVRFK
  68 EALAVAKVCQLQFIRA...EGFVFGHMADEGFTD.ACAGSLLRYRKQID...AEDVLVLTDIKKK
  69 -----------DFIRV...EGFVFSHVADEGIIN.ACAGDLLRYRKLVG...AENIQIFADIKKK
  70 RMG------ADEFYRRaaeAGVTGILAAD--LPP.EEAGDALRAAERYG...IDQIFIVAPTTDN
  71 ------YTINEDFLQ-...---------------.----RVNKIRGSLK...---------ITFN
  72 ----------------...---------------.--------------...-------------
  73 ----------------...---------------.--------------...-------------


            180       190         200       210            220         
             |         |           |         |              |         
   1 HGAHAITADRSIDELTRDLAFFDA..DGVIATGQRTGNSAS.LEE.IEEIGA...A.....THLP
   2 HARPLSSPNLT-VAVKDTIERGLA..DAVILSGWATGSPPN.QED.LELACDa..A.....NGTP
   3 HARPLSSPNLT-VAVKDTIERGLA..DGVILSGWATGSPPN.LED.LELACDa..A.....SGTP
   4 HSSHAITADVSLLETAHAAEFFMT..DGIIITGTATGHAAS.PED.LQQLSG...R.....VKVP
   5 HARPLSSPNLT-VAVKDTIERGLA..DAVILSGWATGSPPN.QED.LELACDa..A.....NGTP
   6 HSSHAITADVSLLETAHAAEFFMT..DGIIITGTATGHAAS.PED.LQQLSG...R.....VKVP
   7 HGSHAIVADRSIPELTRDLAFFDA..DCIIATGQRTGDSAT.IAE.IEEIGG...A.....THLP
   8 HGSHAIVADRSIPELTRDLAFFDA..DCIIATGQRTGDSAT.IAE.IEEIGG...A.....THLP
   9 HSAHAITNDISLKETAKAAEFFRS..DGIIITGASTGCEAN.VDD.VESLVG...E.....TELP
  10 HARPLGTPNLT-TAVQDTIERGLA..DGVILSGWATGSPPS.LED.LELAKAa..A.....QETP
  11 HSSHAITSDVSLLETAHAAEFFLT..DGIVITGTATGHAAS.PQD.LQELSG...R.....VKVP
  12 HALPLGEQNLT-TVVQETIERGLA..DGVIISGRATGSPPS.LED.LELARAa..A.....AGTP
  13 HARPLGTPNLT-TAVTDTIERGLA..DGIILSGWATGSPPN.LED.LELATNa..A.....KGTP
  14 HGAHAITADRSIDELTRDLAFFDA..DGVIATGQRTGNSAS.LEE.IEEIGA...A.....THLP
  15 HSSHAITSDVSLVETAQAAQFFQA..DGLILTGVATGSPAN.VSE.LSQVKK...F.....CSLP
  16 HSSHAITSDVSITETAGAAEFFLS..DGLIVTGSSTGASAE.QGD.LQALRG...K.....TNLP
  17 HSSHAVTADMSVSETAKAAEFFLA..DGLILTGTSTGQEAD.QRD.LKECGQ...S.....VRIP
  18 AAVYLGNRDVC-SIAKSTVFNNNP..DALCVSGLTAGARTD.SAI.LKRVKDt..V.....PDTV
  19 HARPLGTPNLT-VAVQDTIERGLA..DGVILSGWATGSPPS.LED.LELAKAa..A.....GDVP
  20 AAVYLGNRDVC-SIAKSTVFNNNP..DALCVSGLTAGARTD.SAI.LKRVKEt..V.....PDTV
  21 AAVYLGNRDVC-SIAKSTVFNNNP..DALCVSGLTAGARTD.SAI.LKRVKEt..V.....PDMV
  22 HSSHTITSDVSVLETAKAAKFFLA..DGVILTGDATGYPAN.ETE.LIEIKQ...N.....VDIP
  23 AAVYLGNRDVC-SIAKSTVFNNNP..DALCVSGLTAGARTD.SAI.LKRVKEt..V.....PDTV
  24 HSVRFPGIDLA--THIEWTRFFGA..DALIVSGRMTGDAPD.LEK.VRQAKAl..S.....GDRP
  25 HARPLGTPNLT-VAVQDTIERGLA..DGVILSGWATGSPPS.LED.LELAKAa..A.....GDVP
  26 AAVYLGNRDIC-SIAKSTVFNNHP..DALCVSGLTAGTRTD.SAL.LKRVKEt..V.....PDTV
  27 HAQPLHSPNLA-TAVRDTFDRGLA..DGVILSGWATGQPPT.EED.LSVAARa..A.....KGQP
  28 HATHFSNFEN---ALLDTIERGGA..DAVIVTGSRTGSEVD.IQE.LITAKR...I.....SPVP
  29 HSAHALTADVSIAETAQAAEFFLS..DGVVVTGSATGAKAD.PQE.LREVSQ...S.....VRIP
  30 HAQPLSPISLE-AAIADTVERGLA..DAIVLSGWATGKPPL.LKD.LKLARQv..A.....PQVP
  31 HSVRFPGIDLV--THIEWTRFFGA..DAIIVSGRMTGDAPD.IAK.VRQAREl..A.....GDTP
  32 HASPLGAGDLF-QACRDTVERGLA..DGIIVSGVATGSPPR.RED.LVTARAa..V.....PDVP
  33 HATHFSSFEVA---LLDTVERGGA..DAVIITGSRTGSEVD.IQE.LMLAKK...I.....SPVP
  34 SAQYLADRDLA-SITRTTVFATLP..DAICVSGATAGAPTD.TEA.LRIVKAa..A.....GEVP
  35 HAVHFGDFE---DAFLDTVERGLA..DAVVVSGKATGRPVD.VDK.LALAKE...I.....SPVP
  36 HARPLGTPNLT-VAVQDTIERGLA..DGVILSGWATGSPPS.LED.LELAKAa..A.....GDVP
  37 HAQPLSPISLD-AAITDTVERGLA..DAIILSGWATGKPPL.LEE.LELARKv..A.....PQVP
  38 HSAHSITSDVSLIDTAKTAQYFLS..DGIIITGTSTGVKTD.PQE.VRDVKK...S.....VSIP
  39 SAVYLSDRDLA-SITKTTVFATRP..DGICVSGLTAGASTD.SQA.LQVVKDe..A.....GDVP
  40 SAVYLSDRDLA-SITKTTVFATRP..DGICVSGLTAGASTD.SQA.LQVVKDe..A.....GDVP
  41 HAYHFIDFESS---LLDTVERGLA..DAVIISGKRTGKEVD.IEK.LKLAKE...L.....VDVP
  42 HGAHAIVGDRPVEEQVKDLVFFDA..DAVIATGQRTGHAAD.LGY.IRMIKD...A.....AGLP
  43 GATYVAGRELD-RMTRSTVFNGAP..DGLCVSGLTAGAATD.TPT.LKIVKEn..A.....GDVP
  44 SATYLADRDLA-SITRTTVFATAP..DGICVSGATAGSPTD.TDA.LRVVKSa..A.....GDVP
  45 HSAHSVTSDVSIHEMAKDAKFNCA..DGVIVTGSATGSAAS.LEE.MIQVMK...V.....QEFP
  46 HAVHFTNFE---DAVKDTVERGLA..DGIIVTGRRTGESIS.LED.LILAKR...V.....SSIP
  47 HGAPLAPLSMV-EAVSDVLERGGA..DGVIVSGTGTGRPTD.PGD.LEQARAa..A.....AGAP
  48 HAVHFTNFE---DAVKDTVERGLA..DGIIVTGRRTGESIS.LED.LILAKR...V.....SSIP
  49 HSAHSITADVSIQEMAKDAKFNCA..DGVIVTGSSTGSAAS.TEE.MSQVLRg..V.....SEFP
  50 AAQYLAHRDLA-SIARTTVFNCAP..DGLCVSGATAGAATD.TDQ.LRVVKQa..A.....GDTP
  51 HSAHALTADISVAETASAAELFLA..DGVVLTGTATGLPAD.PGE.LREVQR...A.....VKIP
  52 FADSLDKRPLP-DRARSAVFSSVP..DAVLVSGQITGEAAR.MED.LEAVKAv..L.....PETP
  53 HSAALAERPLS-EGVAELLERGHA..DGVIASGAGTGHATD.HDH.LQAVVD...ArdrldADAP
  54 HSAHSVTSDVSIHEMAKDAKFNCA..DGVIVTGSATGSAAS.LEE.MIQVMK...V.....QEFP
  55 HGRPLDDRPVE-EVARDAVERGLA..DAVIVTGSATGSPPR.PEE.VRKVAR...V.....VD-R
  56 HAVHFASLE----DYCLNAERSLA..DAVILTGKTTGGEVS.LEE.LKYAKK...T.....LKMP
  57 FASSLDSRSIG-LRARSAIFSSLA..DAILVSGPLTGQPAQ.ASD.LREVREai.G.....TEVP
  58 FAYSLDRRELA-DRARSAVFSSIP..DAILVSGAITGEAAE.MTD.LIAVKGv..L.....PTTP
  59 HSQPLVETSIAQ-TVRDCIERSGVpiAGVVLTGHATGGAPD.ADE.VVAAARtasE.....YEVK
  60 TGTPLATSGFE-EDLDFALRLGGA..DAVVVTGKSHAATLD.MAA.-RARAA...H.....PAAH
  61 HASPLHQMNLE-SLLLDCKERGFA..DYIIVTGERTGKEPN.PEV.VKMIKN...I.....SPLP
  62 HSSHAITSDVSIAETAKAAEFFLS..DGVIVTGTSTGIPTS.PQD.IQG---...-.....----
  63 HSAHAITNDISLKETAKAAEFFRS..DGIIITGASTGCEAN.VDD.VESLVG...E.....TELP
  64 YQPVLSENDV---EEDLKIGMTRC..DAIAVTENATGQETS.MEK.IELFRKn..L.....GDFP
  65 HSAHAITNDISLKETAKAAEFFRS..DGIIITGASTGCEAN.VDD.VESLVG...E.....TELP
  66 HGMTVYPPTLA-EAVETASTRAAP..DAIVITGRKTGEPPD.PVE.IATARA...H.....TDLP
  67 YQPMLSEKSV---EEDLKIAQQRC..DAIAVTENATGEETS.LEK.IKLFRKq..L.....PEFP
  68 HSSHAITSDVSITETAGAAEFFLS..DGLIVTGSSTGASAE.QGD.LQALR-...-.....----
  69 HSAHALTADISVAETASAAELFLA..DGVVLTGTATGLPAD.PGE.L-----...-.....----
  70 -------QRLKMISEVSSGFHYLV..SVMGVTGARSRVEEStLEL.IERVKG...A.....GSLP
  71 RAFDLVKDPIN---ALNVLAKHKI..DAVLTSGG-TNINTG.LEV.IKQLVDl..N.....LDIE
  72 ------------------------..-------------LL.VNK.IEEIRA...Y.....TKLP
  73 ------------------------..----------GKAED.LQPiLSNIKK...H.....TQTP


         230        240         250       260            270       280 
          |          |           |         |              |         | 
   1 LLVGSGV.NEGNIVEILKR..TSGVIVASSLKEGGVWWN.....PVELARVRSFVAAARPGLEAL
   2 VFIGSGA.SWENIATLLQA..ANGVIVSSSLKRHGRIEQ.....PIDPIRVSQFVEAAHRSWNSK
   3 VFIGSGA.NWENIDTLMQA..ADGVIVSSSLKRHGRIEQ.....PIDPIRVSQFVEAARRSWNSK
   4 LIIGSGV.TRDNIDSYYKD..AHAVIIGSHFKRNGNWLE.....EISEPAVDEFMQKICQLR---
   5 VFIGSGA.SWENIATLLQA..ANGVIVSSSLKRHGRIEQ.....PIDPIRVSQFVEAAHRSWNSK
   6 LIIGSGV.TRDNIDSYYKD..AHAVIIGSHFKRNGNWLE.....EISEPAVDEFMQKICQLR---
   7 LLVGSGV.TEANVVEILKR..TNGVIVASSLKEGGVWWN.....PVDPERVARFVAAARE-----
   8 LLVGSGV.TEANVVEILKR..TNGVIVASSLKEGGVWWN.....PVDPARVARFVAAARE-----
   9 LIIGSGI.TAENLNKYWNI..ADAAIVGSHFKENGNWRG.....ALSEVKVQAFMNKVNGFR---
  10 VFIGSGA.DWDNIGKLMTA..ADGVIVASSLKRQGKITE.....TVDPIRVAQFVEAAKETTI--
  11 LLIGSGV.TKDNIGLYYKD..ANAVIVGSHFKRHGSWLE.....EISEEAVENFMRKVCE-----
  12 VFIGSGA.NWENISTLMQA..ADGVIVSSSLKRHGKIDQ.....PIDPIRVSQFVEATRWTISDK
  13 VFIGSGA.DEDNIGQLIQA..ANGVIVASSLKRHGNINE.....AIDPIRVSAFIEAMAEGLKS-
  14 LLVGSGV.NEGNIVEILKR..TSGVIVASSLKEGGVWWN.....PVELARVRSFVAAAR------
  15 VLVGSGV.TGDNLGDYMG-..ADGVIVGSYFKKGGVWYE.....DVDEERVRNFMEK--------
  16 IIIGSGL.TLANFPSYWTL..AHGAIVGSHFKENGHWSA.....ALCQRRVQTFMEGVETL----
  17 VLIGSGV.TLGNMEKYID-..ANGFIIGSYFKKDGHWSN.....SVVYDKVSSFMDKVKKL----
  18 VLANTGV.CLENVEEQLCI..ADGCVTATTFKKDGVFAN.....FVDQARVAKFMEKVRHI----
  19 VFIGSGA.SIENIGQLLQA..ADGVIVSSSLKRQGKREQ.....SIDPVRVGRFVDTVRACQ---
  20 VLANTGV.CLENVEEQLCI..ADGCVTATTFKKDGVFAN.....FVDQARVAKFMEKVRHI----
  21 VLANTGV.CLENVEEQLCI..ADGCVTATTFKKDGVFAN.....FVDQARVAKFMEKVRHI----
  22 ILIGSGI.TTKNIKNYLS-..SNAVIVGSHFKINGIWKN.....KIDKKKVNNFIKKLRILQ---
  23 VLANTGV.CLENVEEQLCI..ADGCVTATTFKKDGVFAN.....FVDQARVAKFMEKVRHI----
  24 LLIGSGA.DECNIAAFMDV..ADGVIVGSSIKEDGRIEN.....RVDVERVRRFVAA--------
  25 VFIGSGA.SIENIGQLLQA..ADGVIVSSSLKRQGKREQ.....SIDPVRVGRFVDTVRACQ---
  26 VLANTGV.CLENVEEQLSI..ADGCVTATTFKKDGVFAN.....FVDQARVSQFMEKVHHI----
  27 LFIGSGA.SWDNVAQLVPY..VNGVIVASSLKRNGQIEQ.....PIDPIRVSRFVEAWQRA----
  28 VLVGSGV.NPRNIKLFWRY..SDGFIVGTWVKEGGRTIN.....EVSIERATKLAKLVKSLR---
  29 VLIGSGV.TDDNVEHYLQ-..ASAMIIGSHFKKGGYWAN.....GVDAERVKRFMGKMHKL----
  30 LLIGSGA.TAENIGNLIRH..ADGVIVASSLKRPARSAGm10fpLIDPIRVRQFVEALHLGLGE-
  31 ILLGSGT.TEQNIAAFMEV..ADGVIVGSSIKQDGEIAN.....PVDVNRVRRFVAA--------
  32 ILIGSGA.DPANAGDLLGL..ADGVIVASALKRFGKPEQ.....PIDPHRTRQFVDAVHLA----
  33 VIVGSGL.NPRNIRLFWRY..ADGFIVGTWVKEGGKTLN.....EVSLERATRIAKVVKSLR---
  34 VFVNTGV.RAENVAAQLSV..ADGAVVGTYFKKDGLFAN.....AVEKSRVEALMGAAKEFR---
  35 VIVGSGT.SYDNLPELWKY..ADGFIVGTWIKRDGRVEN.....EVSLERARKLVELAKELR---
  36 VFIGSGL.RLRTLANLLQA..ADGVIVSSSLKRQGKREQ.....SIDPVRVGRFVDTVRACQ---
  37 LLIGSGA.TAENIGSLIRR..ADGVIVASSLKRSSRSAGm10fpMIDPIRVRQFVEALHLA----
  38 VLVGSGV.TPENVNEYSS-..ADALIVGSYFKVDGFWKN.....ELSKERILKLISAV-------
  39 VFVNTGV.RAHNAAEQLSI..ADGAIVGTYFKEDGVFEN.....RAVQSRVTELMTVVREF----
  40 VFVNTGV.RAHNAAEQLSI..ADGAIVGTYFKEDGVFEN.....RAVQSRVTELMTVVREF----
  41 VIVGSGT.NYNNLRILWSY..ADGFIIGTWIKKDGKANN.....EIDIDRAKKIVNLAN------
  42 TLVGSGV.TPENANDILDI..VDGVIVASSLKHDGVWWN.....QVDPLRVKAFI----------
  43 VFVNTGV.RPDTVAESLQY..ADGAIVGTWFKREGKFTN.....DVDAARVAELMGVVRE-----
  44 VFVNTGV.RAENVADQLSV..ADGAVVGTYFKKDGLFAN.....AAEKSRVEELMGAARDF----
  45 VLIGSGI.NGKNAREFVK-..AHGFIVGSDFKIGGEWKN.....DLDSGRISKFMKHVN------
  46 VLVGSGV.NPRNFRTLFKY..ADGFIVGTWVKENGKINN.....PVSLERAKILVRMKN------
  47 VLIGSGA.TPQTLRRLSDA..CDGVIAGTALKRDGLISA.....PVDPERVCALKRM--------
  48 VLVGSGV.NPRNFRTLFKY..ADGFIVGTWVKENGKINN.....PVSLERAKILVRMKN------
  49 VLIGSGI.NGKNARDFVK-..AHGFIVGSDFKIGGDWKN.....ELEASRITKFMRHVNS-----
  50 VFVNTGV.RVATLETQLSA..ADGAIVGTAFKYDGIFEN.....QVDVSRVTEFMVEARRVR---
  51 VLIGSGV.TLENVKNYLD-..ANALIIGSYFKREGYWAN.....GVDPDRVKKFMEHISKL----
  52 VLANTGV.KHDTVAEVLRI..ADGCIVGSSLKVDGHTWN.....AVDPDRAKDFMDRA-------
  53 VFVGSGV.TQETVGATLDL..ADGAIVGTALKQNGETTA.....PVDGDRVRALVD---------
  54 VLIGSGI.NGKNAREFVK-..AHGFIVGSDFKIGGEWKN.....DLDSGRISKFMKHVN------
  55 VLVGSGV.TPENAHVFLRAg.AAGFIVGTYFKKNGITEN.....PVDVDRVRELVRFIR------
  56 VLAGSGV.NAENAARILKW..CDGVIVGTYIKRGGL---.....-VDAERVRRIVR---------
  57 LFANTGV.RLENVDDVLSI..ADGCVIGTHFKVDGSTWN.....RVDGGRVSRFMDK--------
  58 VLANTGV.KHATVADVLKV..ADGCIVGSSLKIDGDTWK.....PVDADRAAEFMRLAK------
  59 TVVGSGV.SQLNLSKYWHI..ADGFIIGSSIKLGGKPWN.....PIDKEKARLIASLAERL----
  60 VLLGGGV.TAENFEETMEN..ASGAIVSSSMKDSGSAVG.....RFVPERVEAFMAAAR------
  61 VCVGSGM.TPNNIRDY--K..VDCFIIGTYLKDTD---G.....KIRVERVKEIANAVKS-----
  62 -------.-----------..------------------.....---------------------
  63 LIIGSGI.TAENLNKYWNI..ADAAIVGSHFKENGNWRG.....ALSEVKVQAFMNKVNGFR---
  64 LVIAAGV.TLENAKKQLEL..GDMAIIGSYFKDNYKDFG.....NVSVEHVKTFMDEIKKIR---
  65 LIIGSGI.TAENLNKYWNI..ADAAIVGSHFKENGNWRG.....ALSEVKVQAFMNKVNGFR---
  66 VLAGSGI.CFNTLN-LLKI..VDGAIIGTCLKSGR----.....EVDLEKAARLIKEARQ-----
  67 LIVAAGL.NDKSVKEQLAI..CDAAIVGSNFKDTRKDTG.....DIYAPYVDSFMKIVKELR---
  68 -------.-----------..------------------.....---------------------
  69 -------.-----------..------------------.....---------------------
  70 VMVGFGV.SQPEHVRMLADagADGVIVGSAI--------.....---------------------
  71 ILIGGGV.DKNNIKQCLTV..NNHIHLGRAIRNNSSWNS.....DILVDEINIFKDL--------
  72 IFVGFGIkNYEDVEKIHKI..SDGAIVGTSI------VN.....EFQNENIDEVIKNV-------
  73 IYVGFGV.NKKTAKDKVKG..ADGVIVGSAF--------.....---------------------


             
            
   1 EHHHHHH
   2 GES----
   3 GES----
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  12 GKDYQ--
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