# List of top-scoring protein chains for t04-100-30-n_notor2-scores hidden Markov model. # HMM and HMM E-value scores computed by SAM (c) 1992-2001 Regents of the University of California, Santa Cruz # Sequence Alignment and Modeling Software System # http://www.cse.ucsc.edu/research/compbio/sam.html # ----------------- Citations (SAM, SAM-T99, HMMs) -------------------- # R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: # Extension and analysis of the basic method, CABIOS 12:95-107, 1996. # K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting # remote protein homologies, Bioinformatics 14(10):846-856, 1998. # A. Krogh et al., Hidden Markov models in computational biology: # Applications to protein modeling, JMB 235:1501-1531, Feb 1994. # # FSSP representative for each protein chain taken from FSSP: # ------------------Citations (FSSP) ----------------------------------- # L. Holm and C. Sander (1996) Mapping the protein universe. Science 273:595-602. # #SCOP domains found in each protein chain taken from SCOP: # ------------------Citations (SCOP) ----------------------------------- #Murzin A. G., Brenner S. E., Hubbard T., Chothia C. (1995). #SCOP: a structural classification of proteins database for the investigation of sequences and structures. #J. Mol. Biol. 247, 536-540. Sequence_ID Length Target_Evalue FSSP-rep SCOP_domain SCOP_suid 5S 5N 12S 6S 12S 10N 1nxmA 197 8.00e-02 b.82.1.1 86385 1svpA 161 6.30e-01 1svpA b.47.1.3 26384 2al3A 90 6.83e-01 1a0cA 438 8.08e-01 1a0cA c.1.15.3 29529 1wxxA 382 1.12e+00 1i1qA 520 1.13e+00 1qdlA d.161.1.1 61543 1gzwA 134 1.37e+00 b.29.1.3 90535 1uwwA 191 2.20e+00 b.18.1.23 108079 1bio 228 2.35e+00 5ptp b.47.1.2 26314 1bkcE 256 2.36e+00 1bkcA d.92.1.10 40333 1bkcI 256 2.52e+00 1bkcA d.92.1.10 40334 2gupA 292 2.58e+00 1h9hE 223 2.83e+00 b.47.1.2 103810 1atg 231 2.90e+00 1atg c.94.1.1 35834 2bepA 159 3.12e+00 1igwA 434 3.24e+00 c.1.12.7 62370 1y7bA 542 3.24e+00 1jatA 155 3.48e+00 1u9aA d.20.1.1 62818 1fjsA 234 4.01e+00 1ucyE b.47.1.2 26336 1l0qA 391 4.13e+00 b.1.3.1,b.69.2.3 77644,77645 1qipA 183 4.21e+00 1qipA d.32.1.1 38470 1gxrA 337 4.26e+00 b.69.4.1 70722 1ecpA 238 4.38e+00 1ecpA c.56.2.1 33775 1gyfA 62 4.56e+00 1gyfA d.76.1.1 39749 1rthA 560 4.66e+00 1rthA c.55.3.1,e.8.1.2 33576,43028 1wkbA 810 5.61e+00 2awaA 390 5.92e+00 1ppjA 446 5.99e+00 d.185.1.1,d.185.1.1 104252,104253 1axiB 236 6.07e+00 1axiB b.1.2.1,b.1.2.1 21997,21998 2mprA 421 6.13e+00 2mprA f.4.3.2 43788 1kqfA 1015 6.14e+00 b.52.2.2,c.81.1.1 72871,72872 2pia 321 6.61e+00 2pia b.43.4.2,c.25.1.2,d.15.4.2 25663,31553,37704 1tqzA 133 6.76e+00 1umwA 237 6.91e+00 d.223.1.2,d.223.1.2 99631,99632 1hnjA 317 6.95e+00 1hn9A c.95.1.2,c.95.1.2 35969,35970 1h4wA 224 7.06e+00 b.47.1.2 65622 1khiA 176 7.08e+00 b.34.5.2,b.40.4.5 77408,77409 1xbfA 140 7.28e+00 d.273.1.1 109538 1d2kA 392 7.43e+00 1d2kA c.1.8.5,d.26.3.1 29008,38442 1d7pM 159 7.45e+00 1cztA b.18.1.2 23718 1uwcA 261 7.50e+00 c.69.1.17 100101 1kyfA 247 7.81e+00 b.1.10.1,d.105.1.1 73220,73221 1qtsA 247 7.82e+00 1qtsA b.1.10.1,d.105.1.1 22313,40789 1um5H 217 8.32e+00 1rz2A 254 8.63e+00 b.100.1.1 105130 1nziA 159 9.06e+00 b.23.1.1,g.3.11.1 86449,86450 1s31A 273 9.27e+00 1iyeA 309 1.01e+01 e.17.1.1 83786 1ll7A 392 1.03e+01 c.1.8.5,d.26.3.1 78085,78086 2gu3A 136 1.03e+01 1q8bA 105 1.04e+01 d.58.4.6 96201 1kw3B 292 1.10e+01 d.32.1.3,d.32.1.3 77549,77550 1musA 477 1.14e+01 c.55.3.4 79494 2a31A 223 1.16e+01 1fl2A 310 1.16e+01 1hyuA c.3.1.5,c.3.1.5 59869,59870 2gd9A 189 1.20e+01 1ed5A 444 1.20e+01 1nseA d.174.1.1 42530 1h8gA 95 1.27e+01 b.109.1.1 65735 1cjaA 342 1.28e+01 1cjaA d.144.1.3 41708 1j58A 385 1.30e+01 b.82.1.2 71531 1rypI 222 1.30e+01 d.153.1.4 41877 2aiqA 231 1.30e+01 1mctA 223 1.31e+01 5ptp b.47.1.2 25961 1s83A 223 1.36e+01 b.47.1.2 98718 1wcqA 601 1.37e+01 1gr0A 367 1.37e+01 c.2.1.3,d.81.1.3 70379,70380 1khdA 345 1.38e+01 a.46.2.1,c.27.1.1 77400,77401 1lp3A 519 1.44e+01 b.121.5.2 74169 1p8xA 344 1.45e+01 d.109.1.1,d.109.1.1,d.109.1.1 94365,94366,94367 2fh1A 344 1.47e+01 1dxrH 258 1.50e+01 6prcH b.41.1.1,f.23.10.1 25456,43433 1ppjD 241 1.51e+01 a.3.1.3,f.23.11.1 104258,104259 1ywsA 82 1.52e+01 1dzfA 215 1.52e+01 1dzfA c.52.3.1,d.78.1.1 33344,39753 1x8qA 184 1.54e+01 4bcl 366 1.55e+01 4bcl b.75.1.1 27968 1gjjA 168 1.56e+01 a.140.1.1,a.140.1.1 83291,83292 2ghsA 326 1.60e+01 1lopA 164 1.61e+01 2cpl b.62.1.1 27510 1z2uA 150 1.61e+01 1w2wB 191 1.63e+01 1lcyA 325 1.65e+01 b.36.1.4,b.47.1.1 73834,73835 1xsjA 778 1.69e+01 2fafA 608 1.73e+01 2fimA 276 1.75e+01 1m2tB 263 1.75e+01 b.42.2.1,b.42.2.1 84762,84763 1um0A 365 1.84e+01 d.258.1.1 107942 1olzA 663 1.85e+01 b.1.1.4,b.69.12.1,g.16.2.1 93341,93342,93343 1dpo 223 1.86e+01 5ptp b.47.1.2 25975 1xdwA 331 1.88e+01 1b63A 333 1.88e+01 1b63A d.14.1.3,d.122.1.2 37566,41107 1j4aA 333 1.91e+01 c.2.1.4,c.23.12.1 71502,71503 1p63A 144 1.92e+01 b.42.1.1 94153 1q1uA 144 1.94e+01 b.42.1.1 95608 1k2fA 190 1.98e+01 b.8.1.2 68054 1lam 484 2.02e+01 1lam c.50.1.1,c.56.5.3 33166,33829 2d09A 407 2.10e+01 1ido 192 2.11e+01 1ido c.62.1.1 34139 1l5oA 356 2.18e+01 c.39.1.1 77711 2al1A 436 2.19e+01 1s5aA 150 2.20e+01 d.17.4.10 98525 1d1vA 444 2.21e+01 1nseA d.174.1.1 59101 1k1eA 180 2.27e+01 c.108.1.5 67995 1szqA 483 2.29e+01 e.44.1.1 99045 1deuA 277 2.30e+01 1theB d.3.1.1 37085 1kl7A 514 2.30e+01 c.79.1.1 72678 1t3bA 211 2.32e+01 c.47.1.9,d.17.3.1 106341,106342 2cw6A 298 2.40e+01 1vzwA 244 2.40e+01 1qhtA 775 2.40e+01 1tgoA c.55.3.5,e.8.1.1 33722,43011 1dx5I 118 2.42e+01 1dx5I g.3.11.1,g.3.11.1,g.3.11.1 44302,44303,44304 1cojA 212 2.43e+01 1avmA a.2.11.1,d.44.1.1 15737,38734 1vl2A 421 2.46e+01 c.26.2.1,d.210.1.1 108708,108709 2gnpA 266 2.49e+01 1abrB 267 2.52e+01 1abrB b.42.2.1,b.42.2.1 25563,25564 2cnqA 306 2.52e+01 1eq9A 222 2.54e+01 5ptp b.47.1.2 26068 1qx4A 274 2.57e+01 b.43.4.2,c.25.1.1 104624,104625 2be1A 339 2.58e+01 1ry9A 145 2.63e+01 d.198.1.1 98094 1plq 258 2.65e+01 1plq d.131.1.2,d.131.1.2 41388,41389 1jqgA 433 2.66e+01 c.56.5.1,d.58.3.1 71791,71792 1gy7A 125 2.66e+01 d.17.4.2 70738 5reqA 727 2.67e+01 1reqA c.1.19.1,c.23.6.1 29632,31259 1oq1A 223 2.67e+01 b.29.1.17 93408 1wljA 189 2.69e+01 1aky 221 2.72e+01 1zin c.37.1.1,g.41.2.1 31896,45197 1syxB 86 2.75e+01 1ri6A 343 2.76e+01 b.69.11.1 97503 2olbA 517 2.76e+01 1jevA c.94.1.1 35721 1h7sA 365 2.79e+01 d.14.1.3,d.122.1.2 65705,65706 1zq1C 633 2.81e+01 1gbg 214 2.84e+01 1axkA b.29.1.2 24171 1dxrL 273 2.86e+01 6prcL f.26.1.1 43431 1sy3A 184 2.88e+01 b.60.1.1 106110 1sqsA 242 2.88e+01 c.23.5.5 98968 1fa8A 135 2.95e+01 1qipA d.32.1.1 38486 1nnxA 109 2.96e+01 b.40.10.1 92013 2b18A 164 3.00e+01 1oneA 436 3.02e+01 4enl c.1.11.1,d.54.1.1 29200,38844 3nul 130 3.10e+01 3nul d.110.1.1 40891 2ab5A 269 3.10e+01 1yuwA 554 3.10e+01 2bsaA 303 3.11e+01 1m98A 317 3.12e+01 a.175.1.1,d.17.4.6 78866,78867 1acf 125 3.18e+01 3nul d.110.1.1 40882 1erxA 184 3.19e+01 1np1A b.60.1.1 27164 1ojqA 212 3.22e+01 d.166.1.1 93146 1urrA 102 3.26e+01 d.58.10.1 107998 1w34A 304 3.30e+01 1f9zA 135 3.34e+01 1qipA d.32.1.1 38484 1vr3A 191 3.39e+01 1eu8A 409 3.41e+01 1eu8A c.94.1.1 59502 1cqyA 99 3.43e+01 1b9zA b.3.1.1 22527 1who 96 3.44e+01 1who b.7.3.1 23215 1q8fA 313 3.45e+01 c.70.1.1 96203 2apjA 260 3.45e+01 1e4mM 501 3.46e+01 1e70M c.1.8.4 59226 1vcdA 126 3.48e+01 1y4hA 188 3.50e+01 1cewI 108 3.50e+01 1cewI d.17.1.2 37999 1ve4A 206 3.53e+01 1kvkA 395 3.56e+01 d.14.1.5,d.58.26.3 73060,73061 1wfyA 104 3.58e+01 1r62A 160 3.59e+01 d.122.1.3 104816 2ayh 214 3.60e+01 1axkA b.29.1.2 24172 1is2A 661 3.62e+01 a.29.3.2,a.29.3.2,e.6.1.2 71382,71383,71384 3fruA 269 3.63e+01 1agdA b.1.1.2,d.19.1.1 20657,38150 1yspA 181 3.72e+01 2al2A 436 3.75e+01 3ladA 476 3.80e+01 1lvl c.3.1.5,c.3.1.5,d.87.1.1 30573,30574,40208 1q59A 172 3.81e+01 f.1.4.1 95881 1aohA 147 3.81e+01 1aohA b.2.2.2 22401 1z47A 355 3.82e+01 1wwrA 171 3.86e+01 1yr4A 237 3.86e+01 1npuA 117 3.93e+01 b.1.1.1 92038 2cw9A 194 3.95e+01 1cnzA 363 3.95e+01 1cnzA c.77.1.1 35061 2f91A 237 3.97e+01 1inp 400 3.99e+01 1inp e.7.1.1 42972 2d2jA 329 4.08e+01 1gmmA 133 4.10e+01 b.18.1.10 65314 1i50H 146 4.13e+01 b.40.4.8 61761 1z90A 469 4.15e+01 1r77A 103 4.18e+01 1dekA 241 4.24e+01 1dekA c.37.1.1 31842 1lrzA 426 4.25e+01 a.2.7.4,d.108.1.4,d.108.1.4 78167,78168,78169 1w5cB 510 4.27e+01 1n1tA 641 4.28e+01 b.29.1.15,b.68.1.1 79821,79822 1n62B 809 4.35e+01 d.41.1.1,d.133.1.1 80092,80093 1ntyA 311 4.36e+01 a.87.1.1,b.55.1.1 103873,103874 1ijqA 316 4.42e+01 1ijqA b.68.5.1,g.3.11.1 62506,62507 1wzoA 246 4.44e+01 1hzoA 271 4.47e+01 e.3.1.1 71092 3eipA 84 4.55e+01 3eipA d.26.2.1 38434 1bf2 750 4.55e+01 1bf2 b.1.18.2,b.71.1.1,c.1.8.1 21860,27787,28774 1dgfA 497 4.56e+01 1cf9A e.5.1.1 42782 1pbyB 337 4.59e+01 b.69.2.2 94422 1rdr 461 4.60e+01 1rdr e.8.1.4 43116 1i3zA 103 4.69e+01 d.93.1.1 83667 1wvqA 167 4.73e+01 1g5hA 454 4.75e+01 1g5hA c.51.1.1,d.104.1.1 60270,60271 1hs6A 611 4.79e+01 1hs6A a.118.1.7,b.98.1.1,d.92.1.13 61233,61234,61235 1ts9A 102 4.80e+01 1qniA 581 4.90e+01 1qniA b.6.1.4,b.69.3.1 23042,27642 7ahlA 293 4.91e+01 7ahlA f.6.1.1 43812 1a1x 108 4.94e+01 1a1x b.63.1.1 27514 1r61A 207 4.96e+01 c.8.8.1 97138 1tm0A 350 5.00e+01 d.21.1.3 107147 1b7gO 340 5.01e+01 1b7gO c.2.1.3,d.81.1.1 29992,39907 2c4xA 260 5.03e+01 1zbtA 371 5.05e+01 1u5uA 374 5.07e+01 1xh3A 276 5.13e+01 2ddrA 306 5.14e+01 1eulA 994 5.15e+01 1eulA 1zsoA 164 5.24e+01 1a3aA 148 5.28e+01 1a3aA d.112.1.1 40917 2gfaA 119 5.29e+01 1ybiA 288 5.29e+01 1han 297 5.34e+01 1han d.32.1.3,d.32.1.3 38506,38507 1q0qA 406 5.35e+01 a.69.3.1,c.2.1.3,d.81.1.3 104464,104465,104466 1ym0A 238 5.36e+01 1vmhA 144 5.37e+01 1cv8 174 5.38e+01 1cv8 d.3.1.1 37089 1j99A 293 5.41e+01 c.37.1.5 71618 1c93A 265 5.41e+01 2ebn c.1.8.5 28998 1erjA 393 5.46e+01 1erjA b.69.4.1 27660 1vc3B 97 5.48e+01 2blfA 373 5.49e+01 1yw5A 177 5.52e+01 1el5A 389 5.53e+01 1b3mA c.3.1.2,d.16.1.3 30369,37937 1mf7A 194 5.53e+01 c.62.1.1 84937 2culA 232 5.55e+01 1co6A 107 5.56e+01 1ycc a.3.1.1 15894 1upqA 123 5.56e+01 1exrA 148 5.56e+01 1cll a.39.1.5 17299 1ea7A 310 5.58e+01 c.41.1.1 70086 2gm6A 208 5.58e+01 2az4A 429 5.61e+01 1cruA 454 5.63e+01 1c9uA b.68.2.1 27617 1wakA 397 5.64e+01 1q2bA 434 5.67e+01 b.29.1.10 95624 1r5tA 142 5.70e+01 c.97.1.1 104812 1vjpA 394 5.75e+01 c.2.1.3,d.81.1.3 100828,100829 1vm7A 311 5.79e+01 c.72.1.1 108884 2fp4B 395 5.83e+01 1h8eD 482 5.83e+01 1skyE a.69.1.1,b.49.1.1,c.37.1.11 60747,60748,60749 1r8nA 185 5.88e+01 b.42.4.1 104851 1ww9A 392 5.89e+01 1efdN 266 5.92e+01 1efdN c.92.2.1 35597 1eur 365 5.93e+01 1eut b.68.1.1 27607 2bg9A 370 5.97e+01 1sqgA 429 5.98e+01 a.79.1.3,c.66.1.38 105912,105913 1qnjA 240 5.99e+01 5ptp b.47.1.2 26238 1uv6A 210 6.02e+01 b.96.1.1 100030 1kxqE 120 6.02e+01 b.1.1.1 73171 1cf2O 337 6.03e+01 1b7gO c.2.1.3,d.81.1.1 29994,39909 1rypH 205 6.05e+01 d.153.1.4 41876 2cfuA 658 6.06e+01 2eu9A 355 6.06e+01 1skoA 143 6.08e+01 d.110.7.1 105676 1t0bA 252 6.10e+01 c.23.16.6 106199 1n35A 1267 6.19e+01 e.8.1.4 79935 1pk6A 133 6.21e+01 b.22.1.1 94801 4ptp 223 6.22e+01 1ei1A 391 6.26e+01 1aj6 d.14.1.3,d.122.1.2 37570,41104 1eo1A 124 6.27e+01 1eo1A c.55.5.1 33739 1wrvA 308 6.28e+01 2iwbA 246 6.31e+01 1ev2E 220 6.33e+01 1cvsC b.1.1.4,b.1.1.4 21738,21739 1zc6A 305 6.34e+01 1sz6B 263 6.35e+01 1r1a1 287 6.42e+01 1aym1 1p4tA 155 6.44e+01 f.4.1.1 87779 1ihkA 174 6.47e+01 1bfg b.42.1.1 62384 1sr4A 206 6.47e+01 b.42.2.1 105948 2ffcA 353 6.50e+01 2polA 366 6.54e+01 2polA d.131.1.1,d.131.1.1,d.131.1.1 41356,41357,41358 1lvmA 229 6.56e+01 b.47.1.3 78243 1gvkB 240 6.58e+01 b.47.1.2 70610 2g30A 258 6.60e+01 1x0rA 249 6.61e+01 1obdA 306 6.62e+01 d.143.1.1 86767 1a12A 413 6.67e+01 1a12A b.69.5.1 27663 1smpI 101 6.73e+01 1smpI b.61.2.1 27417 1qz8A 113 6.75e+01 b.140.1.1 96619 1p4kA 295 6.78e+01 d.153.1.5 87772 1k87A 669 6.79e+01 a.176.1.1,c.1.23.2 77286,77287 1e79D 482 6.82e+01 1skyE a.69.1.1,b.49.1.1,c.37.1.11 18272,26437,32317 2ac0A 200 6.82e+01 1vetA 124 6.84e+01 d.110.7.1 108553 1w6nA 134 6.84e+01 1fzyA 149 6.86e+01 d.20.1.1 65072 1vgjA 184 6.91e+01 1jilA 420 6.93e+01 c.26.1.1 66745 1zjkA 403 6.94e+01 1bquA 215 6.98e+01 1bquA b.1.2.1,b.1.2.1 22066,22067 2f4wA 187 7.04e+01 1snlA 103 7.06e+01 a.39.1.7 105820 1p2hA 571 7.07e+01 a.138.1.3,c.3.1.4,d.168.1.1 93930,93931,93932 2f5tX 233 7.14e+01 1i0sA 169 7.14e+01 1i0rA b.45.1.2 61491 1gz8A 299 7.17e+01 d.144.1.7 83405 1u69A 163 7.25e+01 d.32.1.7 107699 1acvA 189 7.25e+01 1fvkA c.47.1.13 90328 2aujD 309 7.26e+01 1nbaA 264 7.27e+01 1nbaA c.33.1.3 31753 2giyA 191 7.27e+01 1mqoA 227 7.27e+01 d.157.1.1 103846 1kexA 155 7.28e+01 b.18.1.2 77350 2d0eA 407 7.29e+01 1q16A 1247 7.29e+01 b.52.2.2,c.81.1.1 95546,95547 1m9sA 605 7.31e+01 b.1.18.15,b.34.11.1,b.34.11.1,b.34.11.1,c.10.2.1 78874,78875,78876,78877,78878 1agjA 242 7.31e+01 1agjA b.47.1.1 25827 1f00I 282 7.32e+01 1f00I b.1.14.1,b.1.14.1,d.169.1.3 22368,22369,42439 1czsA 160 7.33e+01 1cztA b.18.1.2 23714 2f9cA 334 7.36e+01 1ift 263 7.43e+01 1mrj d.165.1.1 42211 1qqqA 264 7.47e+01 1bkpA d.117.1.1 40931 1qhlA 227 7.52e+01 1qhlA c.37.1.12 32382 1evfA 264 7.54e+01 1bkpA d.117.1.1 40932 1uw6A 211 7.70e+01 b.96.1.1 100079 1p1mA 406 7.71e+01 b.92.1.4,c.1.9.9 87696,87697 1qmvA 197 7.71e+01 1qq2A c.47.1.10 33066 1vyoA 128 7.79e+01 1iz5A 249 7.86e+01 d.131.1.2,d.131.1.2 83834,83835 1v8bA 479 7.88e+01 1w8oA 601 7.88e+01 1xt5A 135 7.95e+01 1p5zB 263 7.95e+01 c.37.1.1 87815 1w1hA 151 8.03e+01 2fv7A 331 8.03e+01 1dypA 271 8.10e+01 1dypA b.29.1.2 24185 1vlyA 338 8.10e+01 b.44.2.1,d.250.1.1 108871,108872 1ne8A 117 8.13e+01 b.34.6.2 80424 2c26A 260 8.18e+01 1vqoQ 96 8.20e+01 1t2aA 375 8.25e+01 c.2.1.2 99078 1poxA 585 8.25e+01 1poxA c.31.1.3,c.36.1.5,c.36.1.9 31731,31793,31794 1c4rA 182 8.26e+01 1c4rA b.29.1.4 24229 1o5zA 442 8.26e+01 c.59.1.2,c.72.2.2 92530,92531 1py5A 326 8.26e+01 d.144.1.7 104389 2iwaA 266 8.29e+01 1tupA 219 8.38e+01 1tupA b.2.5.2 22434 5ptp 223 8.44e+01 5ptp b.47.1.2 25831 1vplA 256 8.46e+01 1w9pA 433 8.48e+01 1lj5A 379 8.58e+01 e.1.1.1 73928 1e9pA 151 8.61e+01 1mfmA b.1.8.1 22215 1bsg 266 8.61e+01 1btl e.3.1.1 42729 1zv9A 172 8.63e+01 2g39A 497 8.66e+01 1egnA 434 8.76e+01 1celA b.29.1.10 59411 1v10A 521 8.76e+01 b.6.1.3,b.6.1.3,b.6.1.3 108224,108225,108226 1df7A 159 8.78e+01 3dfr c.71.1.1 34885 1g71A 347 8.80e+01 1g71A d.264.1.1 43268 1uolA 219 8.83e+01 b.2.5.2 99695 1nw3A 416 8.92e+01 c.66.1.31 86288 1p32A 209 8.93e+01 1p32A d.25.1.1 38379 1vfgA 390 8.95e+01 a.173.1.1,d.218.1.4 108570,108571 1jbwA 428 8.97e+01 c.59.1.2,c.72.2.2 62860,62861 1xssA 225 8.99e+01