a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0299 SO0830, 180 res
- gi|47503181|gb|AAT31857.1|_1:177 conserved hypothetical protein [Bacillus anthracis str. 'Ames Ancestor']
- gi|49179490|gb|AAT54866.1| conserved hypothetical protein [Bacillus anthracis str. Sterne]
- gi|47528033|ref|YP_019382.1| hypothetical protein GBAA2742 [Bacillus anthracis str. 'Ames Ancestor']
- gi|49185563|ref|YP_028815.1| hypothetical protein BAS2556 [Bacillus anthracis str. Sterne]
- gi|30257347|gb|AAP26578.1| conserved hypothetical protein [Bacillus anthracis str. Ames]
- gi|30262715|ref|NP_845092.1| hypothetical protein BA2742 [Bacillus anthracis str. Ames]
- gi|51976232|gb|AAU17782.1|_1:177 conserved hypothetical protein [Bacillus cereus E33L]
- gi|52142763|ref|YP_084066.1| hypothetical protein BCZK2477 [Bacillus cereus E33L]
- gi|42781832|ref|NP_979079.1|_1:177 hypothetical protein BCE2775 [Bacillus cereus ATCC 10987]
- gi|42737756|gb|AAS41687.1| conserved hypothetical protein [Bacillus cereus ATCC 10987]
- gi|14972303|gb|AAK74961.1|_1:180 hypothetical protein SP_0830 [Streptococcus pneumoniae TIGR4]
- gi|15900717|ref|NP_345321.1| hypothetical protein SP0830 [Streptococcus pneumoniae TIGR4]
- gi|66878207|ref|ZP_00403701.1| COG3797: Uncharacterized protein conserved in bacteria [Streptococcus pneumoniae TIGR4]
- gi|47569009|ref|ZP_00239699.1|_1:177 hypothetical protein cytosolic protein [Bacillus cereus G9241]
- gi|47554278|gb|EAL12639.1| hypothetical protein cytosolic protein [Bacillus cereus G9241]
- gi|29896421|gb|AAP09700.1|_1:177 hypothetical Cytosolic Protein [Bacillus cereus ATCC 14579]
- gi|30020868|ref|NP_832499.1| hypothetical Cytosolic Protein [Bacillus cereus ATCC 14579]
- gi|68205895|ref|ZP_00558092.1|_1:180 conserved hypothetical protein [Desulfitobacterium hafniense DCB-2]
- gi|68170233|gb|EAM98122.1| conserved hypothetical protein [Desulfitobacterium hafniense DCB-2]
- gi|88713324|ref|ZP_01107407.1|_1:180 hypothetical protein FB2170_08199 [Flavobacteriales bacterium HTCC2170]
- gi|88708234|gb|EAR00471.1| hypothetical protein FB2170_08199 [Flavobacteriales bacterium HTCC2170]
- gi|86142483|ref|ZP_01060993.1|_1:180 hypothetical protein MED217_12574 [Flavobacterium sp. MED217]
- gi|85831235|gb|EAQ49692.1| hypothetical protein MED217_12574 [Flavobacterium sp. MED217]
- gi|29828682|ref|NP_823316.1|_1:181 hypothetical protein SAV2140 [Streptomyces avermitilis MA-4680]
- gi|29605786|dbj|BAC69851.1| hypothetical protein [Streptomyces avermitilis MA-4680]
- gi|91791953|ref|YP_561604.1|_1:179 protein of unknown function DUF1697 [Shewanella denitrificans OS217]
- gi|91713955|gb|ABE53881.1| protein of unknown function DUF1697 [Shewanella denitrificans OS217]
- gi|67941135|ref|ZP_00533376.1|_1:181 conserved hypothetical protein [Chlorobium phaeobacteroides BS1]
- gi|67912652|gb|EAM62259.1| conserved hypothetical protein [Chlorobium phaeobacteroides BS1]
- gi|89896845|ref|YP_520332.1|_8:187 hypothetical protein DSY4099 [Desulfitobacterium hafniense Y51]
- gi|89336293|dbj|BAE85888.1| hypothetical protein [Desulfitobacterium hafniense Y51]
- gi|45656536|ref|YP_000622.1|_1:174 hypothetical protein LIC10638 [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
- gi|45599771|gb|AAS69259.1| conserved hypothetical protein [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
- gi|16414394|emb|CAC97123.1|_1:174 lin1893 [Listeria innocua]
- gi|16800959|ref|NP_471227.1| hypothetical protein lin1893 [Listeria innocua Clip11262]
- gi|88934428|ref|ZP_01140071.1|_1:178 conserved hypothetical protein [Geobacter uraniumreducens Rf4]
- gi|88918886|gb|EAR38062.1| conserved hypothetical protein [Geobacter uraniumreducens Rf4]
- gi|87308468|ref|ZP_01090609.1|_2:179 hypothetical protein DSM3645_12896 [Blastopirellula marina DSM 3645]
- gi|87289025|gb|EAQ80918.1| hypothetical protein DSM3645_12896 [Blastopirellula marina DSM 3645]
- gi|94549597|gb|ABF39521.1|_1:178 protein of unknown function DUF1697 [Acidobacteria bacterium Ellin345]
- gi|16411235|emb|CAC99859.1|_1:174 lmo1781 [Listeria monocytogenes]
- gi|16803821|ref|NP_465306.1| hypothetical protein lmo1781 [Listeria monocytogenes EGD-e]
- gi|47097521|ref|ZP_00235060.1|_1:174 conserved hypothetical protein [Listeria monocytogenes str. 1/2a F6854]
- gi|47014104|gb|EAL05098.1| conserved hypothetical protein [Listeria monocytogenes str. 1/2a F6854]
- gi|57224321|gb|AAW39378.1|_1:184 conserved hypothetical protein [Dehalococcoides ethenogenes 195]
- gi|57233873|ref|YP_182097.1| hypothetical protein DET1387 [Dehalococcoides ethenogenes 195]
- gi|33146304|dbj|BAC79441.1|_1:180 hypothetical protein [Granulicatella adiacens]
- gi|47094150|ref|ZP_00231870.1|_1:174 conserved hypothetical protein [Listeria monocytogenes str. 4b H7858]
- gi|47017475|gb|EAL08288.1| conserved hypothetical protein [Listeria monocytogenes str. 4b H7858]
- gi|46908011|ref|YP_014400.1|_1:174 hypothetical protein LMOf2365_1806 [Listeria monocytogenes str. 4b F2365]
- gi|46881281|gb|AAT04577.1| conserved hypothetical protein [Listeria monocytogenes str. 4b F2365]
- gi|67927762|ref|ZP_00520953.1|_1:180 conserved hypothetical protein [Solibacter usitatus Ellin6076]
- gi|67864936|gb|EAM59939.1| conserved hypothetical protein [Solibacter usitatus Ellin6076]
- gi|13276819|emb|CAC33937.1|_1:182 conserved hypothetical protein [Streptomyces coelicolor A3(2)]
- gi|21224421|ref|NP_630200.1| hypothetical protein SCO6092 [Streptomyces coelicolor A3(2)]
- gi|83856412|ref|ZP_00949941.1|_1:176 hypothetical protein CA2559_04955 [Croceibacter atlanticus HTCC2559]
- gi|83850212|gb|EAP88080.1| hypothetical protein CA2559_04955 [Croceibacter atlanticus HTCC2559]
- gi|90574770|ref|ZP_01231262.1|_1:179 hypothetical protein CdifQ_02001838 [Clostridium difficile QCD-32g58]
- gi|86158718|ref|YP_465503.1|_1:179 protein of unknown function DUF1697 [Anaeromyxobacter dehalogenans 2CP-C]
- gi|85775229|gb|ABC82066.1| protein of unknown function DUF1697 [Anaeromyxobacter dehalogenans 2CP-C]
- gi|86356865|ref|YP_468757.1|_1:169 hypothetical protein RHE_CH01225 [Rhizobium etli CFN 42]
- gi|86280967|gb|ABC90030.1| hypothetical conserved protein [Rhizobium etli CFN 42]
- gi|32443740|emb|CAD73182.1|_35:212 conserved hypothetical protein [Rhodopirellula baltica SH 1]
- gi|32472504|ref|NP_865498.1| hypothetical protein RB3418 [Rhodopirellula baltica SH 1]
- gi|86132441|ref|ZP_01051035.1|_1:176 hypothetical protein MED134_10830 [Cellulophaga sp. MED134]
- gi|85817002|gb|EAQ38186.1| hypothetical protein MED134_10830 [Cellulophaga sp. MED134]
- gi|89517400|gb|EAS20057.1|_1:176 conserved hypothetical protein [Flavobacteria bacterium BBFL7]
- gi|89890485|ref|ZP_01201995.1| conserved hypothetical protein [Flavobacteria bacterium BBFL7]
- gi|81427705|ref|YP_394703.1|_1:180 hypothetical protein LSA0092 [Lactobacillus sakei subsp. sakei 23K]
- gi|78609345|emb|CAI54391.1| Hypothetical protein [Lactobacillus sakei subsp. sakei 23K]
- gi|14021550|dbj|BAB48162.1|_1:179 mll0605 [Mesorhizobium loti MAFF303099]
- gi|13470807|ref|NP_102376.1| hypothetical protein mll0605 [Mesorhizobium loti MAFF303099]
- gi|88855798|ref|ZP_01130461.1|_1:179 hypothetical protein A20C1_06856 [marine actinobacterium PHSC20C1]
- gi|88815122|gb|EAR24981.1| hypothetical protein A20C1_06856 [marine actinobacterium PHSC20C1]
- gi|13880774|gb|AAK45445.1|_20:195 hypothetical protein MT1188 [Mycobacterium tuberculosis CDC1551]
- gi|15840594|ref|NP_335631.1| hypothetical protein MT1188 [Mycobacterium tuberculosis CDC1551]
- gi|76785085|ref|ZP_00772261.1| COG3797: Uncharacterized protein conserved in bacteria [Mycobacterium tuberculosis F11]
- gi|81254936|ref|ZP_00879434.1| COG3797: Uncharacterized protein conserved in bacteria [Mycobacterium tuberculosis C]
- gi|31617935|emb|CAD94046.1|_38:213 HYPOTHETICAL PROTEIN [Mycobacterium bovis AF2122/97]
- gi|31792347|ref|NP_854840.1| hypothetical protein Mb1185c [Mycobacterium bovis AF2122/97]
- gi|92917156|ref|ZP_01285771.1|_37:213 Protein of unknown function DUF1697 [Mycobacterium sp. KMS]
- gi|92438698|gb|EAS96550.1| Protein of unknown function DUF1697 [Mycobacterium sp. KMS]
- gi|91767219|ref|ZP_01269074.1| Protein of unknown function DUF1697 [Mycobacterium sp. MCS]
- gi|91704660|gb|EAS80374.1| Protein of unknown function DUF1697 [Mycobacterium sp. MCS]
- gi|14021194|dbj|BAB47807.1|_1:180 mlr0163 [Mesorhizobium loti MAFF303099]
- gi|13470453|ref|NP_102021.1| hypothetical protein mlr0163 [Mesorhizobium loti MAFF303099]
- gi|2117192|emb|CAB09013.1|_38:213 HYPOTHETICAL PROTEIN [Mycobacterium tuberculosis H37Rv]
- gi|15608294|ref|NP_215670.1| hypothetical protein Rv1154c [Mycobacterium tuberculosis H37Rv]
- gi|77684920|ref|ZP_00800336.1|_1:178 conserved hypothetical protein [Alkaliphilus metalliredigenes QYMF]
- gi|77639286|gb|EAO81658.1| conserved hypothetical protein [Alkaliphilus metalliredigenes QYMF]
- gi|41408729|ref|NP_961565.1|_13:185 hypothetical protein MAP2631 [Mycobacterium avium subsp. paratuberculosis K-10]
- gi|41397087|gb|AAS04948.1| hypothetical protein MAP_2631 [Mycobacterium avium subsp. paratuberculosis K-10]
- gi|27379445|ref|NP_770974.1|_1:169 hypothetical protein bll4334 [Bradyrhizobium japonicum USDA 110]
- gi|27352596|dbj|BAC49599.1| bll4334 [Bradyrhizobium japonicum USDA 110]
- gi|69937979|ref|ZP_00632547.1|_1:170 unknown protein [Paracoccus denitrificans PD1222]
- gi|69150911|gb|EAN64140.1| unknown protein [Paracoccus denitrificans PD1222]
- gi|85373519|ref|YP_457581.1|_1:182 hypothetical protein ELI_03460 [Erythrobacter litoralis HTCC2594]
- gi|84786602|gb|ABC62784.1| hypothetical protein ELI_03460 [Erythrobacter litoralis HTCC2594]
- gi|85710527|ref|ZP_01041591.1|_1:185 hypothetical protein NAP1_08957 [Erythrobacter sp. NAP1]
- gi|85687705|gb|EAQ27710.1| hypothetical protein NAP1_08957 [Erythrobacter sp. NAP1]
- gi|90204531|ref|ZP_01207174.1|_1:181 Protein of unknown function DUF1697 [Mycobacterium vanbaalenii PYR-1]
- gi|90196583|gb|EAS23345.1| Protein of unknown function DUF1697 [Mycobacterium vanbaalenii PYR-1]
- gi|84684863|ref|ZP_01012763.1|_1:177 hypothetical protein RB2654_03104 [Rhodobacterales bacterium HTCC2654]
- gi|84667198|gb|EAQ13668.1| hypothetical protein RB2654_03104 [Rhodobacterales bacterium HTCC2654]
- gi|89340870|ref|ZP_01193116.1|_116:296 Protein of unknown function DUF1697 [Mycobacterium flavescens PYR-GCK]
- gi|89318993|gb|EAS10486.1| Protein of unknown function DUF1697 [Mycobacterium flavescens PYR-GCK]
- gi|53803560|ref|YP_114743.1|_1:177 hypothetical protein MCA2327 [Methylococcus capsulatus str. Bath]
- gi|53757321|gb|AAU91612.1| conserved hypothetical protein [Methylococcus capsulatus str. Bath]
- gi|90592226|ref|ZP_01247861.1|_1:179 Protein of unknown function DUF1697 [Flavobacterium johnsoniae UW101]
- gi|90431950|gb|EAS57324.1| Protein of unknown function DUF1697 [Flavobacterium johnsoniae UW101]
- gi|66965334|ref|ZP_00412901.1|_3:179 conserved hypothetical protein [Arthrobacter sp. FB24]
- gi|66868783|gb|EAL96152.1| conserved hypothetical protein [Arthrobacter sp. FB24]
- gi|71143797|gb|AAZ24270.1|_1:171 conserved hypothetical protein [Colwellia psychrerythraea 34H]
- gi|71278057|ref|YP_268399.1| hypothetical protein CPS_1661 [Colwellia psychrerythraea 34H]
- gi|13423595|gb|AAK24079.1|_29:205 hypothetical protein [Caulobacter crescentus CB15]
- gi|16126347|ref|NP_420911.1| hypothetical protein CC2108 [Caulobacter crescentus CB15]
- gi|42525616|ref|NP_970714.1|_1:174 hypothetical protein TDE0097 [Treponema denticola ATCC 35405]
- gi|41815627|gb|AAS10595.1| conserved hypothetical protein [Treponema denticola ATCC 35405]
- gi|15074357|emb|CAC46003.1|_1:179 CONSERVED HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
- gi|15965177|ref|NP_385530.1| hypothetical protein SMc01009 [Sinorhizobium meliloti 1021]
- gi|15156847|gb|AAK87516.1|_12:184 AGR_C_3207p [Agrobacterium tumefaciens str. C58]
- gi|15889050|ref|NP_354731.1| hypothetical protein AGR_C_3207 [Agrobacterium tumefaciens str. C58]
- gi|86357813|ref|YP_469705.1|_1:174 hypothetical protein RHE_CH02197 [Rhizobium etli CFN 42]
- gi|86281915|gb|ABC90978.1| hypothetical conserved protein [Rhizobium etli CFN 42]
- gi|34495508|ref|NP_899723.1|_1:176 hypothetical protein CV0053 [Chromobacterium violaceum ATCC 12472]
- gi|34101364|gb|AAQ57733.1| conserved hypothetical protein [Chromobacterium violaceum ATCC 12472]
- gi|54017765|dbj|BAD59135.1|_1:179 hypothetical protein [Nocardia farcinica IFM 10152]
- gi|54026257|ref|YP_120499.1| hypothetical protein nfa42860 [Nocardia farcinica IFM 10152]
- gi|84496391|ref|ZP_00995245.1|_1:180 hypothetical protein JNB_02690 [Janibacter sp. HTCC2649]
- gi|84383159|gb|EAP99040.1| hypothetical protein JNB_02690 [Janibacter sp. HTCC2649]
- gi|15458325|gb|AAK99537.1|_1:136 Hypothetical protein [Streptococcus pneumoniae R6]
- gi|15902777|ref|NP_358327.1| hypothetical protein spr0733 [Streptococcus pneumoniae R6]
- gi|72121747|gb|AAZ63933.1|_1:171 conserved hypothetical protein [Ralstonia eutropha JMP134]
- gi|73538410|ref|YP_298777.1| hypothetical protein Reut_B4583 [Ralstonia eutropha JMP134]
- gi|68191306|gb|EAN05962.1|_1:178 similar to Uncharacterized protein conserved in bacteria [Mesorhizobium sp. BNC1]
- gi|69277429|ref|ZP_00612764.1| similar to Uncharacterized protein conserved in bacteria [Mesorhizobium sp. BNC1]
- gi|26541554|gb|AAN85541.1|_39:215 conserved hypothetical protein [Streptomyces atroolivaceus]
- gi|87200502|ref|YP_497759.1|_1:178 protein of unknown function DUF1697 [Novosphingobium aromaticivorans DSM 12444]
- gi|87136183|gb|ABD26925.1| protein of unknown function DUF1697 [Novosphingobium aromaticivorans DSM 12444]
- gi|88806003|ref|ZP_01121521.1|_1:153 hypothetical protein RB2501_10672 [Robiginitalea biformata HTCC2501]
- gi|88783612|gb|EAR14783.1| hypothetical protein RB2501_10672 [Robiginitalea biformata HTCC2501]
- gi|66800655|ref|XP_629253.1|_1:182 hypothetical protein DDB0191819 [Dictyostelium discoideum AX4]
- gi|60462599|gb|EAL60802.1| hypothetical protein DDBDRAFT_0191819 [Dictyostelium discoideum AX4]
- gi|81177409|ref|ZP_00876231.1|_1:176 similar to Uncharacterized protein conserved in bacteria [Streptococcus suis 89/1591]
- gi|80975913|gb|EAP39600.1| similar to Uncharacterized protein conserved in bacteria [Streptococcus suis 89/1591]
- gi|71366479|ref|ZP_00657021.1|_1:178 similar to Uncharacterized protein conserved in bacteria [Nocardioides sp. JS614]
- gi|71157848|gb|EAO08233.1| similar to Uncharacterized protein conserved in bacteria [Nocardioides sp. JS614]
- gi|66801443|ref|XP_629647.1|_1:183 hypothetical protein DDB0184425 [Dictyostelium discoideum]
- gi|60463024|gb|EAL61220.1| hypothetical protein DDBDRAFT_0184425 [Dictyostelium discoideum AX4]
- gi|94313359|ref|YP_586568.1|_4:158 hypothetical protein Rmet_4434 [Ralstonia metallidurans CH34]
- gi|93357211|gb|ABF11299.1| conserved hypothetical protein [Ralstonia metallidurans CH34]
- gi|89209411|ref|ZP_01187833.1|_1:82 Protein of unknown function DUF1697 [Bacillus weihenstephanensis KBAB4]
- gi|89152654|gb|EAR72801.1| Protein of unknown function DUF1697 [Bacillus weihenstephanensis KBAB4]
- gi|55821130|ref|YP_139572.1|_5:139 hypothetical protein, truncated [Streptococcus thermophilus LMG 18311]
- gi|55737115|gb|AAV60757.1| hypothetical protein, truncated [Streptococcus thermophilus LMG 18311]
- gi|50951545|gb|AAT89246.1|_1:159 conserved hypothetical protein [Leifsonia xyli subsp. xyli str. CTCB07]
- gi|50955063|ref|YP_062351.1| hypothetical protein Lxx14320 [Leifsonia xyli subsp. xyli str. CTCB07]
- gi|55739029|gb|AAV62670.1|_5:139 hypothetical protein, truncated [Streptococcus thermophilus CNRZ1066]
- gi|55823044|ref|YP_141485.1| hypothetical protein, truncated [Streptococcus thermophilus CNRZ1066]
- gi|89898973|ref|YP_521444.1|_1:179 hypothetical protein Rfer_0153 [Rhodoferax ferrireducens DSM 15236]
- gi|89343710|gb|ABD67913.1| conserved hypothetical protein [Rhodoferax ferrireducens DSM 15236]
- gi|15073915|emb|CAC45556.1|_1:87 HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
- gi|15964737|ref|NP_385090.1| hypothetical protein SMc00454 [Sinorhizobium meliloti 1021]
- gi|24379656|ref|NP_721611.1|_1:70 hypothetical protein SMU.1232c [Streptococcus mutans UA159]
- gi|24377610|gb|AAN58917.1| conserved hypothetical protein [Streptococcus mutans UA159]
- gi|15149826|emb|CAC50879.1|_2:131 hypothetical protein [Geobacillus stearothermophilus]
- gi|47078467|gb|AAT09880.1|_1:79 hypothetical protein [Streptococcus thermophilus]
- gi|65320045|ref|ZP_00393004.1|_6:53 COG3797: Uncharacterized protein conserved in bacteria [Bacillus anthracis str. A2012]
- gi|65320044|ref|ZP_00393003.1|_1:103 COG3797: Uncharacterized protein conserved in bacteria [Bacillus anthracis str. A2012]
- gi|68208337|ref|ZP_00560459.1|_1:134 hypothetical protein DhafDRAFT_4762 [Desulfitobacterium hafniense DCB-2]
- gi|68167783|gb|EAM95747.1| hypothetical protein DhafDRAFT_4762 [Desulfitobacterium hafniense DCB-2]
- gi|46205833|ref|ZP_00210049.1|_1:95 COG3797: Uncharacterized protein conserved in bacteria [Magnetospirillum magnetotacticum MS-1]
- gi|55821131|ref|YP_139573.1|_12:58 hypothetical protein, truncated [Streptococcus thermophilus LMG 18311]
- gi|55737116|gb|AAV60758.1| hypothetical protein, truncated [Streptococcus thermophilus LMG 18311]
- gi|15073914|emb|CAC45555.1|_2:72 CONSERVED HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
- gi|15964736|ref|NP_385089.1| hypothetical protein SMc00112 [Sinorhizobium meliloti 1021]
- gi|75764865|ref|ZP_00744230.1|_1:32 Hypothetical cytosolic protein [Bacillus thuringiensis serovar israelensis ATCC 35646]
- gi|74487646|gb|EAO51497.1| Hypothetical cytosolic protein [Bacillus thuringiensis serovar israelensis ATCC 35646]

                         10        20         30         40            
                         |         |          |          |            
   1 ...M....T....RYALLVRGINVGGKNKVV.MAELRQELTNL.GLEKVESYINSGNIFF....T
   2 ...M....T....IYIALLRGINVGGHKIIK.MADLKQAFESI.GLKQVKTYIQSGNIVF....K
   3 ...M....T....IYIALLRGINVGGHKIIK.MADLKQAFESI.GLKQVKTYIQSGNIVF....K
   4 ...M....T....IYIALLRGINVGGHKIIK.MADLKQTFESI.GLKQVKTYIQSGNIVF....E
   5 ...M....T....RYALLVRGINVGGKNKVV.MAELRQELTNL.GLEKVESYINSGNIFF....T
   6 ...M....T....MYIALLRGINVGGHKIIK.MADLKQMFESI.ELKQVKTYIQSGNIVF....E
   7 ...M....T....FYIALLRGINVGGHKVIK.MADLKRVFESI.GLKQVKTYIQSGNIVF....E
   8 ...M....-....KYIALLRGINVGGKNKVP.MAQLKQCFTKA.GFQNVVTYINSGNVIF....D
   9 ...M....T....TYIALLRGINVGGHKKIK.MADLRSILEDS.GLERVRTYIQSGNVVF....D
  10 ...Ms...E....TKIALLRGINVGGHRKVP.MAELRQLMTDL.GFDHVKTYIQSGNIIF....N
  11 ...M....T....TYAALLRGINVGGNKKVP.MAELRTLLQGL.GYGGVATYLQSGNAVF....T
  12 ...M....Q....TYIILLRGINVGGNNLVP.MKALTQVLLDA.GFCQIKTYIQTGNILL....Q
  13 ...M....S....TYFSILRGINVGGKRKML.MADLTSLHETL.GFSNVQTYIQSGNVIF....D
  14 kfyM....-....KYIALLRGINVGGKNKVP.MVQLKQCFTKA.GFQNVVTYINSGNVIF....D
  15 ...M....K....TYIALLRGINVSGQKKIL.MKDLSSLFESL.GFMNVQTYIQSGNVLFq...D
  16 ...M....E....KYVALLRAVNVAGKNKVN.MKNLKAALQEE.GFQNVTTYIQSGNLVL....S
  17 ...M....K....IYIALFRGINVGGNNILP.MKELVTLLESL.GLQQVKTYIQSGNAVF....R
  18 m..M....P....SYLAFLRGINVGGKHKLP.MQELIAILESL.GCTNVKTYIQSGNAAF....D
  19 ...M....P....VYICLLRGVNVTGYNKIK.MEELRALCTKL.KFEGAQTFIQSGNVIF....R
  20 ...M....G....NYVALLRAVNVAGKNKVN.MKNLKGALEEE.GFQNVVTYIQSGNLVL....S
  21 ...M....G....NYVALLRAVNVAGKNKVN.MKNLKGALEEE.GFQNVVTYIQSGNLVL....S
  22 ...M....NgskiKYIALLRGVNVGGKNKVS.MPELKAAFENA.GFTEVSTYINSGNVFF....S
  23 ...M....-....RYVLLLRGINVGGKNKVV.MSELKELLKSE.GFSEVDSYINSGNLFF....T
  24 ...M....G....NYVVLLRAVNVAGKNKVN.MKNLQAALQEV.GFQNVITYIQSGNLVL....S
  25 ...M....G....NYVVLLRAVNVAGKNKVN.MKNLQAALQEV.GFQNVITYIQSGNLVL....S
  26 ...M....M....VYISLLRGINVGGNNLVK.MEALRALYEKL.KFRDVVSYVQSGNVVF....R
  27 ...Mt...T....KYAALLRGINVGGSRKVP.MADLRALLTSL.GHDAVRTHLQSGQAVF....A
  28 ...M....N....TYIALLRGINVGGHKKIL.MADLRLLFESL.EFKNVKTYIQSGNILF....K
  29 ...M....K....SYIALLRGINISGKNKII.MSELKASFVEL.GYSEVSTYLNSGNVVFl...S
  30 ...M....S....RYLVLLRGINVGGKNLIG.MPALKAAFETE.GFGDVVTYIQSGNVLV....S
  31 ...M....P....IYIALLRAVNVGGTGALP.MAELKTICEGL.GFTDVKTYIQSGNVLF....R
  32 rktM....T....TWIALFRGINVGGKNKLP.MATLRSTLESI.GCQSVLTYIQSGNVVF....S
  33 ...M....N....TYICLLRGINVGGHKKIK.MADLKTLLTSL.GYNDVVTYIQSGNIIF....K
  34 ...M....A....RYVALLRGVNVSGKNKLP.MALLREAIEAT.PLYDVTTYIQSGNIVF....N
  35 ...M....Q....-YIALLRGINVGGKRKVQ.MNLLRIAFEDA.GFTNVRTYINSGNVLF....E
  36 ...M....Q....TYVALLYSIILGEGRRVV.MADLKAMAEGL.GLKNVRTLVATGNLVF....E
  37 ...M....T....KYVALLRGINVGGKNVIS.MKSLIDCFSAA.GFDGVRTFIQSGNVLF....S
  38 qsgM....A....KFAAFLRGVNVGGVN-LK.MAEVATALTDA.GFCNVRTILASGNVLL....E
  39 qsgM....A....KFAAFLRGVNVGGVN-LK.MAEVATALTDA.GFCNVRTILASGNVLL....E
  40 rrvM....T....RFVAFLRGVNVGGVN-LK.MAEVAAAFEDA.GFTAVKTILASGNVLL....D
  41 ...Msa..K....VFIALFSGINVGGNRIVK.MAELRSFFEDL.GFSDVATYVQSGNVVF....R
  42 qsgM....A....KFAAFLRGVNVGGVN-LK.MAEVATALTDA.GFCNVRTILASGNVLL....E
  43 ...M....-....IYVALLRGINVGGKNKID.MKLLKETFVRI.GMESVVTYINSGNVIF....T
  44 nrgM....T....EYAAFLRGVNVGGVN-LK.MADVKKALTDA.GFTAVRTVLASGNVLL....Q
  45 ...M....G....SFVALLRAVNVGGTGKLP.MSELKAMCEDL.GFAAVRTYIASGNVVF....T
  46 ...M....V....SYVALLRAVNVGGTGKLP.MTELKAMCAAE.GFGKVRTYIASGNVVF....S
  47 ...M....P....RYLALLGSINVGG-NRIK.MIDLKAALEGA.GFEDVATVAASGNVIF....A
  48 ...MaasgQ....RYLALLGSINIGG-NRIK.MADLRTALEDA.GFKDVATVAASGNVIL....T
  49 ...M....Gss..RYVALLRGINVGGRNKIS.MPDLRAVLEDA.GFGNVSTYIQSGNVAF....E
  50 ...M....S....VWVLLLRGINVGGTGKLP.MADLKTHMAAL.GAEAPETYIQSGNAVF....E
  51 spiMgs..T....RYAALLRGINVGGRNKIT.MADLRAAFSEA.GFGGVSTYIQSGNVAF....E
  52 ...M....-....VYVALLRGINVGGNSKVE.MSRLKTMFETL.GCAQVLTYINSGNVIF....S
  53 ...M....A....THLALLRGINVSGHNMMK.MEALKTMLENI.GFQNVRTYLQSGNVFV....E
  54 mp.M....N....SYAVFLRGINVGGIN-IK.MADLRSALAER.GFDGVKTLLASGNVAL....A
  55 ...M....E....KYVILFRGINVGGKNLLP.MKALVPLLEEA.EFEEISSYIQSGNVVL....K
  56 eprM....S....PHIALLRAVNVGG-RKVL.KDDLLGLATDL.GFDDAKTLLASGNLVL....W
  57 ...M....D....-YIALLRGINVGNSIKIN.MKELKTLFEQC.GFSNVSTYINSGNVIF....K
  58 ...M....K....AYVALLHSIVLGDGRRVV.MADLKAMAEAL.GCRAPRTLVATGNLLF....E
  59 pasM....N....DYVALLHSIVLGPGKRLI.MADLRALAEEL.GFAECKTLVATGNLVF....C
  60 ...M....S....TFVALLHSIVLSPGRRVI.MEDLRALAIEL.GYREPRTLVSTGNLVF....E
  61 ...M....E....SCVALIRGINVGKAKRIA.MADLRRMAAQL.GAEDVSTLLNSGNLVC....R
  62 ...M....H....RYAALLRGIMPSNPN-MR.NDKLRGVFEGL.GFEKVATVLSSGNLVF....R
  63 ...M....P....RHLAFLRAINLGAHHKVP.MAELRERLTDA.GFTDVETHIQTGNIAL....T
  64 ...M....T....RYALLVRGINVGGKNKVV.MAELRQELTNL.GLEKVESYINSGNIFF....T
  65 ...M....P....RYIAFLRG--VSPMNA-R.MPELKRCFEAA.GFFEVKTLLSSGNVVF....N
  66 ...M....Tagt.AYIVLFRG--VGGATQLP.VARLREVLPQA.GFRNVSTYINSGNAVL....S
  67 qtg-....P....AYIAFLRAVNVPG-RKVE.MARLREVLTQL.GFMGARTYIASGNAFF....T
  68 ...M....T....RYVALFGSINVGG-NRVT.MADLRWAFERE.GLTGLETVVASGNLLF....D
  69 ...-....-....------------------.MKELREALEAD.GFAAVRTYIQSGNLVF....D
  70 ...M....N....KYLIFLRSINIASQNLIK.MKELKEELSKVkSIKKIETYIQTGNLII....E
  71 ...M....K....K-VVLLRGVTPVGKNKIPkMSHLAEILTEV.GLTSVQTYIQSGNVVC....E
  72 ...M....Rwva.TYIGFLRAINLGAKRKFP.QDAIRAAVEAA.GGTDVETYLNTGNVRF....D
  73 ...Mt...T....KYIVLVRAL----STKIK.MKDLKDQLEKIkGFKNLKTFFTTGNIIV....D
  74 ...-....-....-------------MNA-R.MPELKHCFEAA.GFSEVRTLLSSGNVVF....D
  75 ...M....T....IYIALLRGINVGGHKVIK.MADLKIMFESI.GLKRVKTYIQSGNVVF....E
  76 ...-....-....------------------.-----------.------------EIFFf...D
  77 ...-....-....----------------MS.KADLAAAFEAA.GFAEVVTLLQSGNAVF....A
  78 ...-....-....------------------.-----------.------------EIFFf...D
  79 ...M....H....-YAAFFRNLNLGRPNAPT.KVQLEQAFLDA.GAQEAASFLTNGTLVF....S
  80 ...M....P....VYVALLRAVNVGGTGKLA.MADLKAVCDEL.GFAGAKTFIQSGNVVF....R
  81 ...M....G....NYVVLLRGVNVGGKNKLV.MSDLRQQVTDM.GFVNVKTYINSGNLFF....Q
  82 ...-....-....------------------.----------M.GLGRVRTYIQSGNVLF....E
  83 ...M....K....RCTFLVRGINVGGRNRVV.MEKFCHDLEKL.GFKNVSSFINSGNFFF....D
  84 ridM....T....IYIALLRGINVGGHKIIK.MADLKQAFESI.GLKQVKTYIQSGNIVF....N
  85 ...-....-....------------------.-----------.----------------....-
  86 ...-....-....------------------.-----------.----------------....-
  87 ...M....T....AYACLLFAVNVGG-RKVP.STALRDLAGEL.GLAHARTVVNSGNLVVgpgsS
  88 lskM....K....RCTFLVRGINVGGRNRVV.MEKFCHDLEKL.GFKNVSSFINSGNFFL....-
  89 ...-....-....------------------.-----------.----------------....-
  90 ...-....-....------------------.MADLKRLFESI.ELKHVKTYIPSGNIVF....E


         50               60        70          80             90      
         |                |         |           |              |      
   1 ..S.ID.....S.K.AQLVEKLETFFAVHYPF.IQSFS.LLSLED...FEAELEN..LP..A..W
   2 ..S.EE.....D.I.TFLKERIQSEIKNVFGF.DVPVM.LRTYAE...FTNIIKI..CP..Y..E
   3 ..S.EE.....D.I.TFLKERIQSEIKNVFGF.DVPVM.LRTYAE...FTNIIKI..CP..Y..E
   4 ..S.ER.....D.I.DFLNKRIQSEIKNVFGF.DVPVM.LRTHEE...FINVIKR..CP..Y..E
   5 ..S.ID.....S.K.AQLVEKLETFFAVHYPF.IQSFS.LLSLED...FEAELEN..LP..A..W
   6 ..S.EK.....D.I.DFLNKQIQSEIKNVFGF.DVPVM.LRTRDE...FINLIKR..CP..Y..E
   7 ..S.EE.....G.I.NFLKDQIQSEIKKEFDF.DVPVM.LRTHDE...FINIIKQ..CP..Y..E
   8 a.Q.AQ.....D.H.LMLAEKCKVILEEEFKF.PVDLA.LIDEES...MREALEH..AP..D..W
   9 ..S.EEk....N.T.QNLEIQISETIKEHYDF.EVPVL.IKTRNE...ILRVLED..NP..Y..T
  10 a.D.TE.....D.T.VQLAEKIQKAILEHFGF.EVPVI.CLEAAR...LQHAIKN..NP..Fa.T
  11 ..S.DHg....D.E.QSLAAEVGQAIEKRFGF.TVDVL.VRDHAY...LKAVREA..CP..F..P
  12 ..S.PHsshesD.G.AQLEQDIAKLIHTHFGF.TPDIM.QLSLSE...FSTAAAN..NP..Y..-
  13 ynG.DD.....N.I.RELSTNIQEKIHLEYGY.EVPVI.VLQANE...LADIRRN..NP..F..I
  14 a.Q.AQ.....D.Q.IMLAEKCRVILEEEFKF.PIDLA.LIDEES...MREALEH..AP..A..W
  15 ..K.NK.....N.V.KELIILIEKKIVEVFGF.EVIVF.IRSKEE...LKTIIQS..NP..F..-
  16 ..SnLQ.....T.E.TEVAAKITEVILASFNL.SIDVF.VFSEQN...YKTIIKN..NP..F..P
  17 ..S.TA.....DnI.LRLADTIRSEIKRRHGF.EPCVL.LMEITE...MEKAMAA..NP..F..P
  18 c.K.QR.....N.R.GKLAAEITAAIEANKGF.APLVL.LLEQHQ...LEAIVAA..NP..F..P
  19 c.P.ET.....N.E.AALAKKIGDAIEKKFGF.RPEIM.LRTADE...LRAVVAA..NP..FkkR
  20 ..SiLQ.....T.E.TEVAAKITKVIKAICEL.TIDVF.VFSEQN...YKQIIAN..NP..F..P
  21 ..SiLQ.....T.E.TEVAAKITKVIKAICEL.TIDVF.VFSEKN...YKQIIAN..NP..F..P
  22 c.E.EK.....E.I.TDLQQQCRQVVLDTFSL.EIPIA.VLSVNA...LADALNH..AP..E..W
  23 ..S.SE.....S.M.EKIVSKVEKLLEKNYDF.SIPFA.LLSKET...YLEEIAN..LP..E..W
  24 ..SmLQ.....T.E.LEVATKITEVMKATFDL.TIDVF.VFSEQN...YSQIIAN..NP..F..P
  25 ..SmLQ.....T.E.LEVATKITEVMKATFDL.TIDVF.VFSEQN...YSQIIAN..NP..F..P
  26 a.A.ET.....N.R.ARIADRIEDAIEGEFGH.RPRVV.LRTTAE...LRDLMAR..NP..FarR
  27 a.A.HG.....D.E.DSLAAELAEAIGERFGF.PVDVI.VRDHAY...LRSVVEA..CP..F..P
  28 ..A.PI.....E.N.NGLQELIKQAIKNKYGW.DIPVI.ILTPNK...LDKLVKS..SP..F..T
  29 ..D.VD.....D.N.KVISNTIRLMIKKQFEL.EIPVF.IISQEE...LKDILNN..AP..N..W
  30 ..S.PE.....R.G.PALVPRIEAMLSRAFDY.SASVV.VLSSTQ...LRRVVEH..AP..D..G
  31 ..S.DE.....S.E.KTVEERLGAALGQKMGK.RPGVM.VRSRKE...LDAIAGN..AP..F..P
  32 c.E.PS.....S.K.EAIATRIADAVDENFGF.RPQVM.LLTKDE...FQSAVAN..NP..F..A
  33 ..S.HEk....S.I.DEITAVIKKAIVGAFGF.EVPVF.VLTRKM...LTQVYEN..YA..L..P
  34 ..A.DL.....E.I.ATCEQMIADLLKAEFDL.NVPVI.VREQAA...IKDILKV..NP..F..E
  35 ..T.PE.....T.ElAELVAVCDQLMVTTFGF.SVRIA.IVTADS...LIAAVEQ..AP..N..W
  36 a.R.AT.....D.I.GKLEQRLETAFEKTFGR.HVDII.VRTAEE...WLKLAAG..NP..F..P
  37 c.D.SA.....S.S.AELEVVIERMLHESFDA.EILTV.VRSRDE...LAATIAA..AP..A..E
  38 ..S.TC.....G.A.AEVREKTEATLRERFGY.DAWAL.IYDVDT...VRTIVAA..YP..F..E
  39 ..S.TC.....G.A.AEVREKTEATLRERFGY.DAWAL.IYDVDT...VRTIVAA..YP..F..E
  40 ..S.DA.....D.V.TTVRRTAEQALRERFGY.DAWVL.AYDAAT...VAAVSAA..YP..F..E
  41 a.G.KG.....D.A.TALTRQIEAAFEKKWGF.HSRIL.VRDLSW...FERLVSE..NP..Y..P
  42 ..S.TC.....G.A.AEVREKTEATLRERFGY.DAWAL.IYDVDT...VRTIVTA..YP..F..E
  43 ..D.IE.....H.IkEEIVAIIEKAIFENFQF.HIKVL.IRSIDD...FHYMMRI..LP..E..S
  44 ..S.KA.....G.A.AAVRAKAEAALRERFGY.DAWVL.VYDLDT...VRRVVDG..YP..F..E
  45 ..S.RK.....S.E.AAIKSALEQRLHAYAGA.PVGVL.VRSAAE...MAQVATD..NP..F..P
  46 ..S.DQ.....P.A.LEVKRALEKRLEDHAGK.PVGVI.LRTAKE...MADVLNA..NP..F..P
  47 ..D.ER.....D.P.AMLEIRLESVVQQSFGF.TSCAM.VRSAEE...VRYAIEE..NP..F..H
  48 ..D.ER.....D.P.AMLEVQLESLVQDRFGF.KSCAM.VRTVDE...VRYAIEE..NP..F..H
  49 ..S.DG.....A.R.ASLESDIEALLVRLLES.PPVVV.VRSHRQ...LRGVVED..AP..G..E
  50 ..G.DI.....D.P.DAFATALTERVEALHDH.APRTL.VLPGQD...IIDARDA..YP..F..A
  51 ..S.GR.....R.R.ASLESDIETLLADRLQS.PPVVV.VRSHAE...MRAIVEE..APadF..V
  52 ..D.PR.....P.A.SKLVPLIEAEIEKEFSL.PVRVV.LRDFAN...ISLLNKE..IP..Ad.W
  53 ..S.EE.....E.A.SKVGFMIKQEIFKVFGH.EVPVI.VLSKKD...LELSFAN..NP..YlkE
  54 ..S.PL.....G.A.AALKKDVETCLRESFGY.DAWVV.VLTDAR...LAALVEA..CP..Y..P
  55 ..S.ST.....N.P.ADV---IHKLVMDNFGF.SPELF.ILNEAE...FSSAMTN..NP..Y..-
  56 ..G.EA.....G.-.EGLEARLEDGLERRMGL.RTDFM.VRTAAE...LQAVIAA..NP..F..R
  57 ..S.ND.....K.K.NSITENIEKALHITSGN.EVKVL.VKTKSE...VVEIANS..IP..Gd.W
  58 ..A.PEk....P.L.AELEAELEKAFEKTFGR.HVDII.VRSAED...WSRLAAG..NP..FlaE
  59 a.E.AA.....P.V.REIEDRLERAFETRFGR.HVDIL.VRSGRD...WLKLAAD..NP..F..P
  60 a.D.DM.....R.P.HELEVALEEGFEQKFGK.HVDII.VRSDCT...WMALCGT..NP..F..R
  61 ..-.HR.....S.A.PLLAAGLEAAIVRDCGF.SARAL.ALSGRE...LDAIAAA..NP..Ya.E
  62 t.E.PT.....D.T.AELEDRIQGALNAELGI.AGGTL.VRDYDE...LRDLLDR..DP..F..E
  63 ..S.TMr....S.A.AKVELAIEDLLREWRGF.EVPTI.VRSPAEvhtLAQKIEA..MA..P..L
  64 ..S.ID.....S.K.AQLVEKLETFFAVHYPF.IQSFS.LLSLED...FEAELEN..LP..A..W
  65 a.R.SS.....S.L.TSLERRAGKAMQEELGR.SFDTF.VRPAGY...LQDLIDS..DP..Ya.E
  66 ..S.PL.....T.E.AQVARKVAAAVKEQMGF.EKRVL.VRSLAE...WVKAIEQ..NP..Y..P
  67 ..G.AGn....D.R.ARIVERVEAGLAEAFGF.EVPTI.LRTTDE...LRTELAA..SP..F..V
  68 y.D.DR.....P.L.DGLEDLFSHVMLDRFDI.KSFVA.VRDRAA...IAEAVEG..NP..Ft.G
  69 ..F.PG.....P.P.---ETRIGELIEKNFGF.SPWVL.ALSPEE...LRQAAAA..NP..F..-
  70 ..S.LE.....S.K.IVIKNDVINILSEKFSVkDPKLA.IYNIEE...YKDIISS..NP..F..-
  71 ..T.DI.....L.D.EELSRLIHQTIKEKIGA.ELAII.VKHQME...LTQAVAE..NS..F..G
  72 t.R.LR.....S.R.ARIERTLEDAFEADRGF.AVPTI.VFTPTQ...LREIADR..AA..S..F
  73 vqQ.TM.....T.K.KEVCMEISNVLSNEYQM.EKPLMaIFNIEE...YNDILSS..NP..Y..E
  74 a.R.SA.....S.T.TALERRAEKAMHAELGH.SFGTF.IRPAGY...LRDLIEA..DP..Fa.E
  75 ..S.EE.....E.I.SFLKERIECEINNVFDF.NVPVM.LRANDE...F------..--..-..-
  76 ..S.PM.....M.K.EELLLAIEEFLNKSYAF.NNVFS.LFTLEE...YQNECKY..LP..K..W
  77 a.S.AP.....P.T.ARQAAAVTAALRASTGV.EAGVV.LLTEKR...FRSLAAG..NP..Ll.P
  78 ..S.PM.....M.K.KELLLAIEEFLNKSYAF.INVFS.LFTLEE...YQNECKY..LP..K..W
  79 vgA.RR.....S.P.DRVLAKASKLLNSVCGL.VEPGF.LRSVPY...LAGLVAA..DP..FatV
  80 ..S.DL.....P.E.PAVQAKLEQALAAKMGK.APGVL.LRSRRQ...LDDIAAK..AE..-..-
  81 ..S.DC.....P.R.ANISSRFEQFFADHYPF.V----.------...-------..--..-..-
  82 ..S.EE.....E.E.EPLRERIEQEIAVAHGF.SVSVV.LRTAEE...LRRIAAS..CL..F..S
  83 ..S.PM.....M.K.EELLLAIEEFLNKSYAF.INVFS.LFTL--...-------..--..-..-
  84 l.R.K-.....-.-.-----------------.-----.------...-------..--..-..-
  85 ..-.--.....-.-.-----------------.----M.LRTYAE...FTNIIKI..CP..Y..E
  86 ..-.-M.....S.I.SSKFFLYEKGFSTAFGF.ECAVM.LRAAWE...MADMVEV..LP..F..S
  87 ..G.AS.....S.P.ADVARLLHDGVAERFGV.DAAVA.VLTTER...LRKIVRGtrCP..T..T
  88 ..-.--.....-.-.-----------------.-----.------...-------..--..-..-
  89 ..-.--.....-.-.-----------------.-----.------...-------..--..-..-
  90 ..S.EE.....G.D.TL---------------.-----.------...-------..--..-..-


                      100             110       120          130       
                       |               |         |            |       
   1 ...WS.....R.DLA..RK.D..F.LF.YTEG.LDVDQVIATVES..LEL.KDEVLYFGK...LG
   2 ...ADsl...L.EGE..SM.H..I.AF.LANE.LSKKE-KDQLLI..YKN.MNEDCYIHE...KV
   3 ...ADsl...L.EGE..SM.H..I.AF.LANE.LSKKE-KDQLLI..YKN.MNEDCYIHE...KV
   4 ...VNsl...R.EGE..SI.H..V.AF.LANE.LSELE-KDQLLM..QKN.ETEDCYIHE...KV
   5 ...WS.....R.DLA..RK.D..F.LF.YTEG.LDVDQVIATVES..LEL.KDEVLYFGK...LG
   6 ...VDsl...L.EGE..SI.H..V.AF.LANE.LSGKE-KDQLLM..QKN.ETEDCFIDE...NV
   7 ...VHsl...L.EGE..SV.H..I.AF.LANV.LSEEE-SSQLLT..FKS.ELEDCYIDE...KV
   8 ...WD.....E.DPEa.KH.N..A.LF.VIHP.ATAADIVAEVGA..TKP.EYEQVFAHG...PV
   9 ...DR.....N.ELS..EN.K..I.YFvLLQD.SPEEDKVKELSN..YKF.ENETFTYTP...NC
  10 ...AS.....T.PIE..NL.H..L.TF.LSET.PEESR-VTALEA..MDY.APDQFRYQN...AW
  11 a..AE.....L.EAK..QL.H..V.TY.FSGP.VDAER-FASLDQ..PAF.LPEEFRLGD...RA
  12 ...-Q.....D.KPG..NT.V..H.CY.FCQQ.LPSPD-EARLKE..LAT.STEEYRIEG...RV
  13 ...INgi...T.DIE..RL.H..V.TF.LREP.PHV-EHLNKLNN..MEF.PPDKFSVIG...KH
  14 ...WG.....E.DPEa.KH.N..A.LF.VIHP.ATAADIVAEVGA..TKP.EYEQVFAYG...PV
  15 ...FK.....K.DLN..RI.Y..I.SF.LNES.KKNPD-LTEIEK..VKI.KGEELIVQG...KE
  16 ...PEii...G.EEE..RW.M..I.AF.YNEN.IDIPK-------..QKN.TQAEVIAIG...RA
  17 ...EA.....V.TEP..NT.L..H.LN.FLSS.IPVNPDLKGLEK..LRS.ENERYELKD...KV
  18 a..AQ.....D.DPK..SL.H..F.FF.LTAP.AKKPD-LAALEK..LTA.ADESFLLAG...NL
  19 ...KD.....V.PPD..RM.L..V.HF.LLSE.-PLEEVRTKLNG..TE-.KIEEVHFKG...RE
  20 ...PEti...G.EEE..RW.M..A.AF.YNEN.IDIPR-------..QKN.DQAEVIAIG...RV
  21 ...PEti...G.EEE..RW.M..A.AF.YNEN.IDIPR-------..QKN.DQAEVIAIG...RV
  22 ...WD.....R.DAD..SK.Hn.A.IV.VIAP.AKADAVIKTVGE..AKP.EYEKVAYHG...QV
  23 ...WN.....E.EFA..RK.D..I.LF.YSQG.TNSDEVVEFAKD..SEL.YNEKVYIGK...NA
  24 ...PEti...G.EEE..RW.M..A.AF.YNEN.IAIAR-------..QKN.EQAEVIAIG...RV
  25 ...PEti...G.KEE..RW.M..A.AF.YNEN.IAIAR-------..QKN.EQAEVIAIG...RV
  26 ...AG.....I.EPG..KL.V..V.TF.LAGE.LP-DEARVKLES..LPK.TPEEMHLHV...RE
  27 a..AE.....L.EAR..QL.H..V.TY.FSAP.VEADR-FAAIDA..PAF.RPEEFRLGD...RA
  28 ...-N.....D.QLE..KS.Y..F.CF.YQSK.PK-SENVTSLNK..QQF.IDEHFVATS...TC
  29 ...WG.....D.NNK..EI.YdnL.IF.MFPD.LSYDEFYDEVGN..PKE.EYEKVYHYK...NA
  30 ...FG.....S.RPErfRY.D..A.IF.LKPP.LSPAQALERVP-..VNP.DVDEVTAGP...GV
  31 ...-D.....A.KPN..FL.L..V.YF.LPEK.PPADA-LDKM--..VAP.DGEEAKLAA...RE
  32 ...DA.....V.AAP..KT.L..H.YF.FLST.PPVHPDLATIAN..LAT.ATERFDLIE...NV
  33 ...PE.....C.-IA..SS.Y..F.T-.LLHT.LPSTEEIALVNN..LEL.PNEHFIATE...NC
  34 ...TR.....T.IES..SK.F..M.SFgFFDK.IPVTEKIDEVMS..FST.EMETFKIVD...DV
  35 ...WGa....A.AGT..SH.N..L.IV.AIAP.KTAAELSEQLGP..VKA.DYEQVAVTG...QF
  36 ...ADsa...E.AGD..QV.A..V.RV.MRKP.APVED-VAALQA..YAA.EDEKVLPCA...GD
  37 ...HG.....S.SEL..LS.D..V.LF.LKRP.FTAAEAMEQLPE..FND.DVDSIAPGP...DA
  38 ...CE.....L.EGY..QS.Y..V.TF.VADA.AILDE-LSALAD..TAG.PDENISRGPdplGV
  39 ...CE.....L.EGY..QS.Y..V.TF.VADA.AILDE-LSALAD..TAG.PDENISRGPdplGV
  40 ...RE.....V.EGH..HS.Y..V.TF.VTDE.QVLDE-LAALAA..DAG.PEEKIERGE...GV
  41 ...EAa....A.DHT..KL.H..A.YA.LDRE.PTAEE-VARLAE..KCT.GPERFEVKG...DV
  42 ...CE.....L.EGY..QS.Y..V.TF.VADA.AILDE-LSALAD..TAG.PDENISRGPdplGV
  43 ...WK.....N.NEDm.KC.D..V.LF.LWEE.IDNEEVLNKL-V..IKP.KIDTVMYIP...GA
  44 ...RE.....V.DGY..QS.Y..V.TF.VADA.AVLDE-LAALP-..-AG.PDERIRRGPdplGV
  45 ...-K.....A.APN..RT.V..A.IF.LDKA.PPADA-LSGIRG..QKN.--EELRLGR...RE
  46 ...-D.....A.PPS..GT.V..A.IF.LDSP.PPADT-LETMKH..RK-.-DEEVRLGK...RE
  47 gtgPE.....H.GSD..KM.V..HsIF.LSQQ.PDTTAVDALIEE..HRAkGSERLALGD...RV
  48 gtgPE.....H.GSD..KM.V..HsIF.LSEQ.PEQNAVDALIAD..HASkGSERLALGD...RV
  49 ...FA.....E.RHT..EH.HrdV.IF.VKAP.LTVERAMEVVQ-..LRD.GVDDAWPGP...GV
  50 ...EG.....F.DHP..KFaN..I.WF.CTDA.PDAPD-LARLED..HAT.ATERFALKG...RW
  51 ...AR.....T.VDH..RR.D..V.VF.LKEP.LTADRALEVIQ-..VRD.GVDEVWPGP...GV
  52 ...VN.....D.TTQ..KT.D..V.MF.LWEE.LDNEDVMQKLQI..-KP.DLDRVRYLP...GA
  53 ...KD.....I.DIK..RL.Y..I.VF.VSIA.LK-KEHIHDLKI..SQF.KPDEASIDE...NR
  54 ...AE.....D.KTT..HT.Y..V.TL.SSDT.AVLDELFEAGSR..LD-.GTQQQRLGP...EA
  55 ...QT.....F.EGK..FV.H..F.YF.CHNA.IELNQ--EKMTK..YLA.ESEVYLVKD...KV
  56 ...EQaa...T.RPN..HL.L..V.SF.LKTP.ID-GDTVEVLRA..AIK.GREEIHAEG...RA
  57 ...QN.....N.DDL..KT.D..V.AY.LFES.IDNENIINELPI..KKE.YIQVIYVKG...AL
  58 ...SE.....R.DPA..SV.H..V.RV.MRLP.LEVD-MREKLLG..YCS.RGERVAIVD...GD
  59 ...HG.....-.NPP..DV.C..V.RV.MREP.LD-ENVLGLFDK..SR-.QREEVAVVG...GD
  60 ...-D.....G.SGD..QV.I..V.RV.MRLP.ID-PEKVEALKP..LMA.EGQRLAVVG...GD
  61 ...LA.....D.DPA..RL.L..V.AF.PLEP.AALADC-ERVEY..ERG.GAERLHVGA...GA
  62 gl.VH.....E.RGS..YL.T..V.TF.FKRP.IDDPEPAA---P..ADP.LTRVVGYDE...PT
  63 ...ID.....S.SA-..RR.Y..V.AF.AKGE.VSKDA-QRALTA..YAD.TPERSRVVG...RD
  64 ...WS.....R.DLA..RK.D..F.LF.YTEG.LDVDQVIATVES..LEL.KDEVLYFGK...LG
  65 ...FS.....IaSSA..KR.V..V.TF.LRGP.VP-PDV--KLPI..ERD.GASIVKAGA...TE
  66 ...DV.....V.AEP..TK.L..H.HF.ALER.EPEAQAVKALQG..KAT.GAERFVLNG...RS
  67 ...GR.....Q.PAP..DE.R..F.SM.VYSS.GPLTDGEFPLRS..AKG.DWEVLGACG...AT
  68 ...IG.....A.D-N..QV.H..T.LF.LERQ.PDQAAFDKLVAD..QAArGLEKFAIGN...RC
  69 ...-R.....D.DAG..KT.V..H.FF.FLDR.EPETVNRDLAEE..LRA.HSEQWALTG...RV
  70 ...-D.....L.SIP..KS.V..F.VF.FPTG.ESLDQCEYEKEKsgMTE.KSKWELING...II
  71 ...EG.....Y.DPF..RV.H..L.VF.TNDE.IN-GEKLNKLLH..QDF.GDEELRLGS...QC
  72 ...--.....G.HGG..RH.Y..V.SL.LKES.PSAAA-VAEVEA..LAS.AEEVARVSG...RA
  73 ...-K.....S.NET..KT.V..I.FF.PINEfLKQSDCDKDKDF..MTK.SSQWQLVNG...VI
  74 ...FD.....L.APGa.KR.V..V.TF.LRSP.V-APEI--TLPI..ERD.GASIIKASA...AE
  75 ...--.....-.---..--.-..-.--.----.------------..---.---------...--
  76 ...WE.....N.DLY..RK.D..V.LF.YTVQ.LDKDELKRVINS..FDL.VDETLHFRE...LG
  77 ...LG.....D.DES..KL.M..V.TV.LDHD.LPAG--LEVPAD..DEI.APEAVRLGH...RA
  78 ...WE.....N.DLY..RK.D..V.LF.YTVQ.LDKDELKRVINS..FDL.ADETLHFRE...LG
  79 ...VD.....A.SVY..EY.C..V.TF.LHPA.AEVPATLS-LRS..RRG.DVEVFRFTGt..EA
  80 ...--.....-.---..--.-..-.--.----.------------..---.---------...--
  81 ...--.....-.---..--.-..-.--.----.------------..---.---------...--
  82 ...EDal8asA.EGE..SL.Y..V.GF.LLRE.PS-REGMERLAP..YKN.EDEQYYIAG...RE
  83 ...--.....-.---..--.-..-.--.----.------------..---.---------...--
  84 ...--.....-.---..--.-..-.--.----.------------..---.---------...--
  85 ...ADsl...L.EGE..SM.H..I.AF.LANE.LSKKE-KDQLLI..YKN.MNEDCYIHE...KV
  86 ...EGei8asN.PAV..EH.L..Y.VY.LLDG.SDIRQQFDGLIR..TYT.GRDRMVLGA...NE
  87 ...--.....-.---..--.-..-.--.----.------------..---.---------...--
  88 ...--.....-.---..--.-..-.--.----.------------..---.---------...--
  89 ...--.....-.---..ML.L..I.TF.LPEP.PPADA-LDKL--..VAP.DGEEVRIDG...RE
  90 ...--.....-.---..--.-..-.--.----.------------..---.---------...--


         140          150         160       170           180   
          |            |           |         |             |   
   1 IFWGKFSEE..S.YSKTAYHKYLLKVPF..YRHITIRNAKTFDKIGQM...LK.K...
   2 VYL--FFKT..S.IRNSKLMNQFQK--I..HTPATVRNWRTVNKLKAI...VE.Si..
   3 VYL--FFKT..S.IRNSKLMNQFQK--I..HTPATVRNWRTVNKLKAI...VG.Si..
   4 VYL--FFKN..S.IRNSKLMNQFQK--L..HTPATVRNWRTVNKLKVI...VE.Gm..
   5 IFWGKFSEE..S.YSKTAYHKYLLKVPF..YRHITIRNAKTFDKIGQM...LK.K...
   6 VYV--FFKN..S.IRNSKLMNQF--QRL..HTPATVRNWRTVSKLKTI...VE.Gm..
   7 VYL--FFKN..S.IRNSKLMNQFQK--L..HTPATVRNWRTVNKLKAI...VE.Im..
   8 IFWSAQLKT..-.FSRTRWSK-IVGTKT..YKSVTIRNANTTKKMLELt..LS.D...
   9 VYL--RCAL..G.AGKAKCGIGFFESKL..KVSATSRNYRTLQKLIEL...SS.N...
  10 IYL--NIPG..K.YHKTKLSNALFEKKL..KVSATTRNWKTVLKLSEL...LQ.Ay..
  11 LYL--YAPD..G.LGRSKLGETLARPRLlkGIVATSRNWNTVVKLEEL...TG.A...
  12 LYL--HAPD..G.IGRSKLAAN-IEKCL..KVPATARNLNTVNKLLDM...VN.T...
  13 VYL--FCAG..K.SSDSKLTNQLFERTL..KAYATTRNWKTVTKLAEL...YT.Grqt
  14 IFWSAQLKT..-.FSRTRWSK-IVGTKT..YKSVTIRNANTTKKMLELt..LS.D...
  15 IYF--FSPK..G.YGVSKLSNNFLEKKL..HVSATTRNWKTVVTLSEL...T-.-...
  16 LYIH-VFSN..Q.IHQLKL-PVFLGEYK..KTLTTTRNWRTTAKLLTL...LD.Sqe.
  17 FYL--HAPD..G.IGRSKLGAN-AEKLL..GVLMTGRNWRTVSKILAL...AK.Enf.
  18 FYL--HAPS..G.IGRSKLAEK-VDRHL..GVATTARNWRTVSKMLEL...AG.K...
  19 IYI--YFPD..G.IGRSDL-RSVLDRTL..KKTATARNFNSVMKILEI...AE.Tles
  20 LYVH-VFSN..Q.IHTLKL-PVFLGQYK..MALTTTRNWRTTLQLKTL...LD.Sqe.
  21 LYVH-VFSN..Q.IHTLKL-PVFLGQYK..MALTTTRNWRTTLQLKTL...LD.Sqe.
  22 IFWSAPIKT..-.FSRTRWLKVVSTSAY..G-NITIRNANTIKKLLQP...GS.Dkg.
  23 VFLGLRWDE..GeFLKTTYHKQVLKQPF..YKTITIRNGKTFDKIAEL...LQ.Keqn
  24 LYIH-IFSN..Q.IHTLKL-PVFLGEYK..KTITTTRNWRTTLQLQTL...LD.Sqe.
  25 LYIH-IFSN..Q.IHTLKL-PVFLGEYK..KTITTTRNWRTTLQLQTL...LD.Sqe.
  26 LFT--YFPN..G.MGQSKLSLAAVDRAL..KIPGTARNWNTVSKLLAL...AE.Glei
  27 LYL--YAPD..G.LGRSKLAEALARPRVnkGLVATSRNWNTVTKLVEL...TG.P...
  28 VYI--VYEK..G.AGRAKLTTNKMESTL..NVSITARNYKTVSKLITL...SK.Tl..
  29 IFWS-FSRK..D.YKKTNWWSKTASSNV..SDKITIRTANTVRKIVGM...R-.-...
  30 LYYSRLTA-..K.ASQSRMSR-IVGTPI..YKQMTIRNWNTTARLHEL...MG.E...
  31 IYV--HYPN..G.SGRSKLKLPALK---..--PGTSRNLNTVRKLAEMaaaME.A...
  32 FYL--HAPD..G.FGTSKLAKS-VERKL..GVGITARNHSTVEKLAGL...LNpE...
  33 VYI--YPEK..G.YGKAKATNTFFEKRL..NVLATTRNYKTIVKLLAL...SN.-...
  34 MYF--YCGV..G.FGKTKLTNAWFEKKL..GVRSTMRNYNTTLKLTEL...--.-...
  35 VFWSAPVKT..H.-GRTRWATIVKNKAL..YQWITIRNANTARKLAAL...AQ.D...
  36 IWV--VFSR..E.RPTSRLLATMNHKRL..GI-GTSRNWNTVRKLAEM...VG.Srq.
  37 LYFSRTVAN..S.L-QSRI-DRLRNNRL..SRRMTVRNWRTTNRLLEM...LD.Spn.
  38 LYWQ-VPKG..S.TLDSTIGQTMGKKRY..KSSTTTRNLRTLAKVLR-...--.-...
  39 LYWQ-VPKG..S.TLDSTIGQTMGKKRY..KSSTTTRNLRTLAKVLR-...--.-...
  40 VYWQ-VPKS..A.TLDTTIGKTMGKKRY..KSSTTTRNLRTLDKVLRS...VD.Sar.
  41 LYLSA--PD..G.LGKS-VFANLIPRVL..KVPGTARNWRSVLALLEM...AG.Qagk
  42 LYWQ-VPKG..S.TLDSTIGQTMGKKRY..KSSTTTRNLRTLAKVLR-...--.-...
  43 VLWS-VDKR..N.VTKSGLMK-LVSTAL..YKRMTVRNVNTTRKVYAI...MQ.Gldk
  44 LYWQ-VPKG..S.TLDSTIGKTMGKPRY..KSSTTTRNLRTLVKVLS-...--.-...
  45 IYV--HYGD..G.MGTSKLVIPAAK---..--TGTARNMNTIATLARM...AA.El..
  46 IYV-AYGAA..G.MGRSKLAIPAA----..-ADGTARNMNTIAKLAEL...AA.Si..
  47 LFLGYV--H..G.VGVSDLSNKTLERRL..KVKGTARNMTSLKRILGK...MV.A...
  48 LFLDYIY--..G.VGVSDLSNKVLERRL..KCKGTARNMNSLKNILSK...MG.-...
  49 VYFTRVIAE..K.A-RSRMSR-IVGTPE..YRLMTIRNWATTTRMLTL...LD.Emr.
  50 FFLDA--PD..G.IGRSKLAER-VEKAL..GVPATARNLNTVTKLARM...VE.Arqt
  51 VYFTRVSAE..R.T-RS-MMNRIVGKPE..YRLMTIRNWATTSQMLSI...LD.Gmg.
  52 VVWN-VDRD..K.VTRSGMLR-LVGTPV..YKLMTIRNVNTLRKLFAL...MS.Nike
  53 IFI--KYAV..G.AGKTRLELKYIEKKL..NVIGTMRNLNTVTNLLKM...YE.E...
  54 MAW-LAPAG..G.TLDSPFSRLSSKARY..KSTTTTRNLRTMIKVRDAtkaMG.N...
  55 FYL--HAPH..G.IGRSKLVTN-IEACL..GQPASGRNLNTTNKVSAM...LK.Km..
  56 LYID--FKD..G.IGDSTLDRDWKKTKR..EPLGTMRNWNTVLKLADM...VA.A...
  57 IWN--VRRE..D.YNKSHL-NKIISHKA..YKDMTIRNVNTARYLAKC...--.-...
  58 LWVD--FAG..K.ASESKLLGALTTKRL..GI-GTVRNWNTVKGLRGM...VA.G...
  59 LWID--FRG..K.PSESRLLSVLTTKRL..GI-GTTRNANTVNGLAEM...LR.-...
  60 LWID--FAS..K.PSQSKLLSALTTKRL..GV-GTMRNWNTVCGLAQM...IM.-...
  61 AYL--WCAE..G.LMDSPLAADFT-RRL..GERFTVRNWATTLKLLRA...LP.R...
  62 RALLTVIDN..S.TPKTPDFMAWLDKTY..GKDITTRTWLTVQKVVKK...ME.S...
  63 VLL--EIDG..N.FHTARLAGAKLERLA..GTPLTARDIKVVRAIDEK...WS.Tt..
  64 IF-------..-.---------------..------------------...--.-...
  65 IF-SVYIPD..P.-KKGPVFMSLLERTF..GKDITTRTLDTVIKCARA...--.-...
  66 LYL--HTPD..G.MGRS-LFVPKIEPTL..KVAMTARNWRTVLALRDM...AA.Airp
  67 AYVRWRLVN..G.RPVNPVPA--IEKTF..GVQATGRFFHTSEKILAA...AG.Kg..
  68 IYIDFV--E..G.VGDSKLSSAFLERRL..GCRGTARNVRSIARILAK...MS.-...
  69 AYL--RAPD..G.IGRSKLASKMDRVFP..GTQITARNRNTVEKLLGM...LP.Eetg
  70 YYFGKQCGP..S.SELTSGFKSLNKKIK..NLPHTARNFNTVRKILEL...AN.K...
  71 LYM--YLPR..D.ARKKKLNTNYLEKQL..DITATMRKLSVISRLSEM...AK.-...
  72 VHL--LLGA..N.YHQARLTNAVIERHL..GV-ATNRNLTVIEALADK...WA.R...
  73 WYLGPTTGTasD.VKIFKLIEKKIKPGS..NHEYTFRTLRSSQKILDT...AN.K...
  74 VF-SAYLPD..P.-KKGPVFMTLLERSF..GKDITTRTLDTVIKCARA...--.-...
  75 ---------..-.---------------..------------------...--.-...
  76 VYWGKHDKT..S.YNQTVYHKNLLKSSF..YSYVTIRNARTFSNIGHC...LK.K...
  77 VYQ--WCPL..G.VSKSVLPAAFW-RAV..GPVATARNQWTVGRILNE...LD.Rrg.
  78 VYWGKHDKT..S.YNQTVYHKNLLKSSF..YSYITIRNARTFFKHLSL...FE.Kirn
  79 LSLSRKIGN..T.AG-SP--NALLEKQL..GLPATTRNWNTVRRLA-L...AH.S...
  80 ---------..-.---------------..------------------...--.-...
  81 ---------..-.---------------..------------------...--.-...
  82 IFL--LFSR..S.VRNSKLSANLQK--L..DV----------------...--.-...
  83 ---------..-.---------------..------------------...--.-...
  84 ---------..-.---------------..------------------...--.-...
  85 VYL--FFKT..S.IRNSKLMNQFQK--I..HTPATVRNWRTVNKLKAI...VE.Si..
  86 IYL--LCHE..S.IRDSKLATSLGK--L..KVSLTARNWKTISKLYEI...TR.E...
  87 ---------..-.---------------..------------------...--.-...
  88 ---------..-.---------------..------------------...--.-...
  89 IYV--HYPN..G.SGRSKLKLPALR---..--PGTARNLNTIRKLAEMaaaME.D...
  90 ---------..-.---------------..------------------...--.-...