(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.soe.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0295
    • gi|76646156|ref|XP_878963.1|_61:159 PREDICTED: similar to Probable dimethyladenosine transferase (S-adenosylmethionine-6-N,N-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) (HUSSY-05) isoform 2 [Bos taurus]
    • gi|76646158|ref|XP_586750.2|_214:312 PREDICTED: similar to Probable dimethyladenosine transferase (S-adenosylmethionine-6-N,N-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) (HUSSY-05) isoform 1 [Bos taurus]
    • gi|86438246|gb|AAI12887.1| Dimethyladenosine transferase [Bos taurus]
    • gi|67463767|pdb|1ZQ9|B_186:284 Chain B, Crystal Structure Of Human Dimethyladenosine Transferase [Taxonomy]
    • gi|67463766|pdb|1ZQ9|A Chain A, Crystal Structure Of Human Dimethyladenosine Transferase [Taxonomy]
    • gi|6324989|ref|NP_015057.1|_214:317 Essential 18S rRNA dimethylase, responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; Dim1p [Saccharomyces cerevisiae]
    • gi|1370549|emb|CAA98001.1| DIM1 [Saccharomyces cerevisiae]
    • gi|1169344|sp|P41819|DIM1_YEAST Dimethyladenosine transferase (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
    • gi|601876|gb|AAA57357.1| dimethyladenosine transferase [Taxonomy]
    • gi|42573814|ref|NP_975003.1|_249:368 S-adenosylmethionine-dependent methyltransferase/ rRNA (adenine-N6,N6-)-dimethyltransferase/ rRNA methyltransferase [Arabidopsis thaliana]
              10        20         30          40        50            
              |         |          |           |         |            
   1 SSFLTNFDEWDNLLRICFSRKRKTLHAIF.KR.N.AVLNMLEHNYKNWCTLNKQ.V.P.V.NFP.
   2 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVHNIiI.P.E.DFS.
   3 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVHNIiI.P.E.DFS.
   4 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVHNIiI.P.E.DFS.
   5 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVHNIiI.P.E.DFS.
   6 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVHNIiI.P.E.DFS.
   7 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVHNIiI.P.E.DFS.
   8 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVHNIiI.P.E.DFS.
   9 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVQNTvI.P.E.DFS.
  10 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVQNTvI.P.E.DFS.
  11 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVQNTvI.P.E.DFS.
  12 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVQNTvI.P.E.DFS.
  13 PPPPINFQEWDGLVRIAFVRKNKTLAASF.KS.T.AVQELLEKNYRIHCSLHNIsV.P.E.NFS.
  14 PPPPINYQEWDGLTRIAFVRKNKTLSAAF.KQ.T.TVLTMLEKNYKLHCSLNNKiI.T.E.GFN.
  15 PPPPINFQEWDGLVRIAFVRKNKTLSAAF.KS.S.AVEQLLEKNYRIHCSLHNVtI.P.A.DFS.
  16 PPPPINFQEWDGLVRIAFVRKNKTLSAAF.RN.K.GVVEMLEKNYRVHCSVKNIaI.P.D.NLD.
  17 PPPPVNFQEWDGLVRIAFVRKNKMLSAAF.KS.A.AVEKLLEKNYKIHCSVHNIeI.P.E.DFN.
  18 PPPPVNFVEWEGLLRLCFMRKNKTLLAIF.RL.S.NVIEVIEDNYRKVCSMKNKpL.P.K.DFN.
  19 -----NFDEWDNLLRICFSRKRKTLHAIF.KR.N.AVLNMLEHNYKNWCTLNKQ.V.P.V.NFP.
  20 PRPQVDYNEWDGLLRIVFVRKNRTISAGF.KS.T.TVMDILEKNYKTFLAMNNE.M.V.D.DTKg
  21 ---MINFDEWDNLLRICFSRKRKTLHAIF.KR.N.AVLNMLEHNYKNYCTFNKI.I.P.I.NYS.
  22 PPPPVNFVEWEGLLRLCFMRKNKTLMAIF.RL.S.NVIEVIEDNFRKVCSFKNKpI.P.K.DLN.
  23 ---MINFDEWDNLLRICFSRKRKTLHAIF.KR.N.AVLNMLEHNYKNYCTFNKI.V.P.I.NYS.
  24 ---MINFDEWDNLLRICFSRKRKTLHAIF.KR.N.AVLNMLEHNYKNYCTFNKI.V.P.I.NYS.
  25 PRPQIDFNEWDGLLRIVFVRKNRTISAGF.KS.T.TVLEILEKNYKTFLAINNQ.S.I.D.ETEn
  26 PPPPLAFEEWDGLLRIVFLRKNKTIGACF.KT.S.SIIEMVENNYRTWCSQNER.M.VeE.DFD.
  27 PRPNIDFNEWDGLLRICFVRKNKTIAAGF.KS.N.NILDILEKNYKTFLSTANA.A.A.N.GDDs
  28 PPPPVNFTEWDGLTRIAFLRKNKTLAATF.KV.S.SVIEMLEKNYKVFRSLRNEpL.E.E.GFN.
  29 PRPQVDFNEWDGLLRIVFVRKNRTIAAGF.KS.T.TVLEILEKNYKAFLATQSA.V.P.T.TSSg
  30 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVHNIiI.P.E.DFS.
  31 PPPPINYTEWDGLTRIAFLRKNKTLAAAF.KQ.T.TVLTTLEDNFKLHCSLKNIdV.P.A.DLN.
  32 PPPPINFVEWDGLVKLCFSRKNKTLSGIF.RV.S.SVIETLNQNYKTYCALEGK.M.N.T.DGSd
  33 PRPNIDFNEWDGLLRIVFVRKNKTIAAGF.KS.S.NVIEILEKNYKTFLATQES.N.N.N.DSMm
  34 PRPPIDFNEWDGLLRVCFVRKNKTINAGF.KT.S.AVLAVLEKNYQTWLSTQGE.I.I.P.EGSn
  35 PRPPVDFNEWDGLLRIVFVRKNRTISAGF.KS.T.AVLEIMEKNYKAYLATTND.A.M.V.DDAk
  36 ---VVDFGEWDGMIRICFSRKRRTLRSLF.KK.Q.SVLSILESNYKSWCTINNK.V.P.V.YKP.
  37 PRPQVDFNEWDGLLRIVFVRKNRTIAAGF.KS.T.TDLEILEKNYKAFLATQSA.V.P.T.TSSg
  38 ---VVDFGEWDGMIRICFSRKRRTLRSLF.KK.Q.SVLSILESNYKSWCTINNK.V.P.V.VKP.
  39 PPPPVKFEEFDGLNRIIFSRANKTLRAGF.KA.K.GVVELLEKNYRTWCAEQGA.I.I.EdNFD.
  40 -RPNISWDEWDGMLRICFVRKNKTLRAGF.MA.T.KVRALIERNWITWVSMHPE.K.V.T.QADi
  41 PLPPVSFKEWDGLVRLCFNRKNKTLGAIF.KQ.K.RVLELLEKNYKTMQSLQLT.S.D.A.EKGe
  42 PPPAIPFEEFDGLTRIVFSRRNKTVRASFfDA.R.GVIDMLESNYKTYCAVKEI.M.P.E.QGS.
  43 -KPEISWDEWDGMLRICFVRKNKTLRAGF.MA.T.KIRQMIERNWITWAAMHPE.K.V.S.QGDv
  44 -RPNIAFEEFDGLLRIAFNRKNKTLYAGF.NQ.K.EVLNMCERNYKVYCTLNNI.P.I.D.ESLa
  45 ---SVNFREWDGLMRICFSRKKKTIRANF.NN.S.SVLNILENNYKVWSSINQKdP.C.G.NMP.
  46 PPPPLAFEEWDGLLRIVFLRKNKTIGACF.KT.S.SIIEMVENNYRTWCSQNER.M.VeE.DFD.
  47 -RPNVSWEEWDGMLRVCFNRKNKTLHASF.LGvK.EVLAMAERNYKVWCTMNDI.P.I.D.ESVv
  48 PPPPVNFTEWDGLTRIAFLRKNKTLAATF.KV.T.SVLEMLEKNYKLYRSLRNEpI.E.D.DFK.
  49 PPPPISYTEWDGLTRIAFSRKNKTLGAAF.RQ.S.VVLATLEKNYKSFCSVNNKeI.P.P.GFN.
  50 PGPQVNKKEWDGFLRVCFIRKNKTLGSIF.KQ.K.SVLSMLEKNFKTLQAVLAS.L.Q.N.NGEp
  51 PAPDVDFEEWDGLVKFIFNRKNKKVSSIF.RT.K.NAVQTLYEKYCSYQKMEGKtS.V.K.SLA.
  52 PAPDVDFEEWDGLVKFIFNRKNKKVSSIF.RT.K.NAVQTLYEKYCSYQKMEGKtS.V.K.SLA.
  53 ------PPEWEGLLRLCFMRKNKTLMAIF.RL.S.NVIEVIEDNFRKVCSFKNKpI.P.K.DLN.
  54 -RPAISWDEWDGMLRICFVRKNKTLRAGF.MG.N.KTRAMIERNWITFATMYPE.K.V.T.QADi
  55 PRPDISYDEWDGLLRIAFVRKNKTLRSSFlGT.S.SVLSMLESNYTTWCAQNDI.P.V.E.VGPd
  56 PAPVLNYIEWDGLLRVCFMRKNKQLSAIF.KN.K.SVLQVLEKNFETYQKIKAI.E.Q.G.AVEe
  57 PIPNINYIEWDGLLRICFNRKNKQLSAIF.KN.K.SVLKTLEHNFHVIEQEGIK.V.N.D.PANn
  58 PAPPLNLVEFDGFLRICFLRKHKTLSSLF.RI.S.SVLEVMEKNLRIIAKIRNIpI.D.E.NLD.
  59 PAPSVDFEEWDGLVKHIFNRKNKKVSSIF.RT.K.NTVRTLYDKYCSYQRMEGV.KdV.K.TFE.
  60 PPPDVDFEEWDGLVKMLFSRKNKKSSSIF.RT.K.AAAQALYDKYVSYRKMEGG.Q.P.V.GTAt
  61 -VPAVGLEELDGVLRICFSRKNKTLRASF.LD.S.H--EICERNWITWTSMYPD.K.V.S.EKDl
  62 PRPPIDLGEFDRFLKICFLRKNKTLRANF.KN.S.SLVSKIKN---------DP.N.F.E.NTT.
  63 PPPGLDLDEFNGLTRILFSKKNKTLGAIF.KT.K.SLLDDLANNIARLDEISRL.H.K.P.AQHe
  64 PRPPINIEEFNRLLKICFLRKNKRLSGIF.KR.T.VIQDMQKVNKAYTLQEIEK.K.-.-.---.
  65 PPPPINFQEWDGLVRITFVRKNKTLSAAF.KS.S.AVQQLLEKNYRIHCSVHNI.V.-.-.---.
  66 PPPPINFQEWDGLVRIAFVRKNKTLSAAF.KS.S.AVEQLLDHNYRIHCSLHN-.-.-.-.---.
  67 --------EWDGLLRLVFARKNKTIGANL.GG.K.SIASHLRKIYMETCCTKGL.S.P.T.PEVi
  68 --PDVNVQEWLAFTRTCFGKKNKTLGSMF.RQ.K.KKVMELQSLSAGRHGSNVE.V.M.N.---q
  69 --PNVDLAEWLAFTRSCFGQKNKTLGAIF.KQ.KrKVLELFRRSRCAEERCDGN.A.N.A.GG-g
  70 --PDVNVQEWLAFTRTCFGKKNKTLGSMF.RQ.K.KKVMELQSLSAGRHGSNVE.V.M.N.---q
  71 -----------------------------.--.-.--------NYKVYCSLHNI.P.I.D.ESIa


           60         70        80        90         
           |          |         |         |         
   1 ....FKKYCLDVLE.HLDMCEKRSINLDENDFLKLLLEFNKKGIHFF
   2 ....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNAEGIHF-
   3 ....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNAEGIHF-
   4 ....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNAEGIHF-
   5 ....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNAEGIHF-
   6 ....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNAEGIHF-
   7 ....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNAEGIHF-
   8 ....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNAEGIHF-
   9 ....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNAEGIHF-
  10 ....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNAEGIHF-
  11 ....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNAEGIHF-
  12 ....IADKIQQILT.NTGFSDKRARSMDIDDFIRLLHGFNAEGIHF-
  13 ....IAEKIEGILT.ETGFSEKRARSMDIDDFMALLHGFNSQGIHF-
  14 ....IKDMISDILQ.KADAENKRARTMDIDDFISLLHAFNAKGVHFI
  15 ....IAKKIEGVLQ.EASFCEKRARSMDIDDFMVLLHAFNSAGIHF-
  16 ....MKEKVVSVLE.KIEFEGKRARTMDIDDFLKLLSSFNTEGIHF-
  17 ....IAPKIESILQ.ESKFSDKRARSMDIDDFMVLLHAFNSAGIHF-
  18 ....MKKLIEETLT.ASGYAENRARKMRVEDFLALLLAFNKADIHFL
  19 ....FKKYCLDVLE.HLDMCEKRSINLDENDFLKLLLEFNKKGIHFF
  20 s6dvVKEKIDTVLK.ETDLGDKRAGKCDQNDFLRLLYAFHQVGIHF-
  21 ....FKTFCLDTLK.DLEMEEQRSINLDENDFLKLLLEFNKKGIRFF
  22 ....MKKVIEETLT.ASGYGESRARKMRVEDFLALLLAFNKADIHFL
  23 ....FKTFCLDTLK.DLEMEEQRSINLDENDFLKLLLEFNKKGIRFF
  24 ....FKTFCLDTLK.DLEMEEQRSINLDENDFLKLLLEFNKKGIRFF
  25 lqslIKQKIETVLK.ETGLAEKRAGKCDQTDFLKLLYAFHQVGIHF-
  26 ....VKSLIDGVLQ.QCNLQDARASKCGQTEFLSLLHAFHQVGVHF-
  27 13diVKAKIEQVLT.ETGFSDKRAAKLDQTDFLKLLYAFHQVGLHF-
  28 ....MQEKVIGILE.ELEMATLRARSMDIDDFMRLLRAFNSKGIHF-
  29 d7neVKEKIEQVLS.ETGLAEKRAGKCDQTDFLKLLYGFHQVGIHF-
  30 ....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFN-------
  31 ....VKEMVEKILE.KADASDKRARSMDIDDFMAVLQAFNAEGFHF-
  32 eq..MKELIIKTLT.DNDFLDSRSSKLDINDFLKLLNKFHETGIHF-
  33 12dvVKNKITTVLT.ETGFSDKRAGKLDQTDFLKLLYAFHQVGIHF-
  34 lsdvVKQKINKILT.DTGIGEMRSAKCDQTEFLTLLNEFHKAGIYF-
  35 g7eqVKQKIETVLA.ETGLSDKRAGKCDQTDFLKLLYAFHQVGLHF-
  36 ....FKEFVIEILE.SSGLAERRSITVSIAEFLKLLLAFNEVGIHFC
  37 d7neVKEKIEQVLS.ETGLAEKRAGKCDQTDFLKLLYGFHQVGIHF-
  38 ....FKEFVIEILE.GSGLAERRSITVSIAEFLKLLLAFNEVGIHFC
  39 ....IREKVESILV.ETGFADSRAAKMDVDDLLKLLAAFNVEGIHF-
  40 73klVQAKIQRVLE.QTNLANARAQKCDENNFLRLLHGFNTEGIHF-
  41 47acFKEKIMGILQ.QGDFAEKRASKLSQVDFLYLLSLFNKAGIHF-
  42 ....FADMVKQVLV.ETGSAENRAAKMDIDDLLTLLAAFHEKGIHF-
  43 79rlIQFKIERILD.TAGLANHRANKCDENDFLRLLHACNTEGIHF-
  44 76liVKAKLNKVLT.STGLADKRARQCDQNDFLKLLLAFHEEGIHF-
  45 ....FKTFIFKILE.DSGLSSKRGFNVDINEYFRLLFEFNKNGVHFV
  46 ....VKSLIDGVLQ.QCNLQDARASKCGQQS-LSLLHPFHQVGRSFW
  47 63elVRSKIEKVLK.DTDLAEQRANKCDQNDFLRLLAAFNAEGIHF-
  48 ....MQDKVISILE.EQDMAAKRARSMDIDDFMRLLLAFNSAGIHF-
  49 ....IKEKVEQVLK.QVEGDQKRARTMDIDDFMVLLHAFNSEGIHF-
  50 43seFKEKVMNVLK.EGGFEEKRSSKLSQQEFLYLLSLFNKSGIHF-
  51 ....EFKEHLETVM.QDPVFESRARLLDQDSITKLLCHFTENGIHFV
  52 ....EFKEHLETVM.QDPVFESRARLLDQDSITKLLCHFTENGIHFV
  53 ....MKKVIEETLT.ASGYGESRARKMRVEDFLALLLAFNKADIHFL
  54 72klIQVKLQRILD.RTELANARAQKCDENDFLRLLHACNKEGIHF-
  55 61klVRKKVRQVLEdDTGLADKRARMCDEGDFLKLLWSFNQRGIHF-
  56 72klFKEKIHKILE.DSGYLEKRPAKLDIDDYLKLLFVFNQNEIHF-
  57 59npFRLKINEILK.TNDMFQKRPVKMDNDDFLQLLCAMNAQGIHF-
  58 ....VKADVLQILE.ESGRAKSRAAQLTLDDFLELIYAFMKKNYHFC
  59 ....EFRQHLESIL.QEPIFDKRARVLDQESIMELLCCFTKNDIHFV
  60 22leQFRVLLAAVI.ADPMFEQRSRMLDEVALMTMLAHFIKHGIHFI
  61 34nlIRTKIEHVLE.TTELAEARAVKCDENDFLKLILAFRENNIYF-
  62 ....PDDVFERVLS.GADLAGARAAKMDLDDFLALLLEFRKVNIYF-
  63 23vqLRERIAEALA.EANLTDTRPNHMAIPDLLSLMCALAAKGVRF-
  64 ....----TTGILR.K--LGADRAAKMDIEDFLFLLLEFKKEGISF-
  65 ....----------.--------------------------------
  66 ....----------.--------------------------------
  67 10vaMEEKISSILR.DSGFEKKRARTLDEDDFLRLLL----------
  68 27smFKERVIEILR.TNGFEEKRPSKLSHRELLHLLSLFNQAGIFF-
  69 38avFKAKITGALE.SCELAGKRPSKLSNDELLRLLKLLNEQGVRF-
  70 27smFKERVIEILR.TNGFEEKRPSKLSHRELLHLLSLFNQAGIFF-
  71 80lvVKAKVNKVLT.STALGEKRARQCDQNDFLKMLLG---------