a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0295
- gi|47226710|emb|CAG07869.1|_213:311 unnamed protein product [Tetraodon nigroviridis]
- gi|77748206|gb|AAI06333.1|_208:306 Unknown (protein for MGC:130862) [Xenopus laevis]
- gi|13874484|dbj|BAB46866.1|_215:313 hypothetical protein [Macaca fascicularis]
- gi|27151490|sp|Q95KJ0|DIMH_MACFA Probable dimethyladenosine transferase (S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
- gi|67463767|pdb|1ZQ9|B_187:285 Chain B, Crystal Structure Of Human Dimethyladenosine Transferase [Taxonomy]
- gi|67463766|pdb|1ZQ9|A Chain A, Crystal Structure Of Human Dimethyladenosine Transferase [Taxonomy]
- gi|7657198|ref|NP_055288.1|_215:313 dimethyladenosine transferase [Homo sapiens]
- gi|14790071|gb|AAH10874.1| Dimethyladenosine transferase [Homo sapiens]
- gi|4050050|gb|AAC97955.1| putative dimethyladenosine transferase [Homo sapiens]
- gi|27151492|sp|Q9UNQ2|DIMH_HUMAN Probable dimethyladenosine transferase (S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
- gi|76646158|ref|XP_586750.2|_215:313 PREDICTED: similar to Probable dimethyladenosine transferase (S-adenosylmethionine-6-N,N-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) (HUSSY-05) isoform 1 [Bos taurus]
- gi|86438246|gb|AAI12887.1| Dimethyladenosine transferase [Bos taurus]
- gi|3646270|emb|CAA08815.1|_59:157 putative dimethyladenosine transferase [Homo sapiens]
- gi|3859994|gb|AAC72947.1|_27:125 unknown [Homo sapiens]
- gi|76646156|ref|XP_878963.1|_62:160 PREDICTED: similar to Probable dimethyladenosine transferase (S-adenosylmethionine-6-N,N-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) (HUSSY-05) isoform 2 [Bos taurus]
- gi|62642979|ref|XP_215477.3|_320:418 PREDICTED: similar to RIKEN cDNA 1500031M22 [Rattus norvegicus]
- gi|74222329|dbj|BAE26964.1|_215:313 unnamed protein product [Mus musculus]
- gi|18043925|gb|AAH19799.1|_215:313 RIKEN cDNA 1500031M22 [Mus musculus]
- gi|21313560|ref|NP_079723.1| dimethyladenosine transferase [Mus musculus]
- gi|74148362|dbj|BAE36330.1| unnamed protein product [Mus musculus]
- gi|12847736|dbj|BAB27687.1| unnamed protein product [Mus musculus]
- gi|27151491|sp|Q9D0D4|DIMH_MOUSE Probable dimethyladenosine transferase (S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
- gi|26347035|dbj|BAC37166.1|_62:160 unnamed protein product [Mus musculus]
- gi|72008162|ref|XP_779962.1|_202:300 PREDICTED: similar to dimethyladenosine transferase [Strongylocentrotus purpuratus]
- gi|66523698|ref|XP_624425.1|_208:306 PREDICTED: similar to ENSANGP00000016944 [Apis mellifera]
- gi|91091694|ref|XP_972612.1|_208:306 PREDICTED: similar to CG11837-PA [Tribolium castaneum]
- gi|57525891|ref|NP_001003556.1|_208:306 hypothetical protein LOC445162 [Danio rerio]
- gi|50417873|gb|AAH78286.1| Zgc:101122 [Danio rerio]
- gi|21358017|ref|NP_651660.1|_208:306 CG11837-PA [Drosophila melanogaster]
- gi|16769516|gb|AAL28977.1| LD35950p [Drosophila melanogaster]
- gi|27151493|sp|Q9VAQ5|DIMH_DROME Probable dimethyladenosine transferase (S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
- gi|7301735|gb|AAF56847.1| CG11837-PA [Drosophila melanogaster]
- gi|54638406|gb|EAL27808.1|_208:306 GA11224-PA [Drosophila pseudoobscura]
- gi|6048291|emb|CAB58154.1|_209:307 dim1 [Schizosaccharomyces pombe]
- gi|19112914|ref|NP_596122.1| hypothetical protein SPBC336.02 [Schizosaccharomyces pombe 972h-]
- gi|26556992|sp|Q9USU2|DIM1_SCHPO Dimethyladenosine transferase (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
- gi|50293399|ref|XP_449111.1|_215:317 unnamed protein product [Candida glabrata]
- gi|49528424|emb|CAG62081.1| unnamed protein product [Candida glabrata CBS138]
- gi|52782776|sp|Q6FKY3|DIM1_CANGA Dimethyladenosine transferase (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
- gi|55624270|ref|XP_517743.1|_215:316 PREDICTED: putative dimethyladenosine transferase [Pan troglodytes]
- gi|6324989|ref|NP_015057.1|_215:318 Essential 18S rRNA dimethylase, responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; Dim1p [Saccharomyces cerevisiae]
- gi|1370549|emb|CAA98001.1| DIM1 [Saccharomyces cerevisiae]
- gi|1169344|sp|P41819|DIM1_YEAST Dimethyladenosine transferase (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
- gi|601876|gb|AAA57357.1| dimethyladenosine transferase [Taxonomy]
- gi|55240843|gb|EAA09266.2|_208:306 ENSANGP00000016944 [Anopheles gambiae str. PEST]
- gi|58385178|ref|XP_313763.2| ENSANGP00000016944 [Anopheles gambiae str. PEST]
- gi|44981468|gb|AAS51253.1|_215:319 ACR026Wp [Ashbya gossypii ATCC 10895]
- gi|45185713|ref|NP_983429.1| ACR026Wp [Eremothecium gossypii]
- gi|52782780|sp|Q75C90|DIM1_ASHGO Dimethyladenosine transferase (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
- gi|49654352|emb|CAG86824.1|_217:327 unnamed protein product [Debaryomyces hansenii CBS767]
- gi|50420303|ref|XP_458685.1| hypothetical protein DEHA0D05819g [Debaryomyces hansenii CBS767]
- gi|52782772|sp|Q6BSY5|DIM1_DEBHA Dimethyladenosine transferase (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
- gi|57229319|gb|AAW45752.1|_227:325 rRNA (adenine-N6,N6-)-dimethyltransferase, putative [Cryptococcus neoformans var. neoformans JEC21]
- gi|58259713|ref|XP_567269.1| rRNA (adenine-N6,N6-)-dimethyltransferase [Cryptococcus neoformans var. neoformans JEC21]
- gi|50255682|gb|EAL18415.1| hypothetical protein CNBJ3380 [Cryptococcus neoformans var. neoformans B-3501A]
- gi|68467333|ref|XP_722328.1|_217:326 putative dimethyladenosine transferase [Candida albicans SC5314]
- gi|68467562|ref|XP_722214.1| putative dimethyladenosine transferase [Candida albicans SC5314]
- gi|46444295|gb|EAL03571.1| likely dimethyladenosine transferase [Candida albicans SC5314]
- gi|46444170|gb|EAL03447.1| likely dimethyladenosine transferase [Candida albicans SC5314]
- gi|50306253|ref|XP_453098.1|_216:320 DIM1_KLULA [Kluyveromyces lactis]
- gi|49642232|emb|CAH00194.1| DIM1_KLULA [Kluyveromyces lactis NRRL Y-1140]
- gi|52788270|sp|P78697|DIM1_KLULA Dimethyladenosine transferase (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
- gi|50551823|ref|XP_503386.1|_215:317 hypothetical protein [Yarrowia lipolytica]
- gi|49649255|emb|CAG78965.1| unnamed protein product [Yarrowia lipolytica CLIB122]
- gi|52782774|sp|Q6C7H6|DIM1_YARLI Dimethyladenosine transferase (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
- gi|39589178|emb|CAE57911.1|_209:307 Hypothetical protein CBG00961 [Caenorhabditis briggsae]
- gi|23497221|gb|AAN36768.1|_255:353 dimethyladenosine transferase, putative [Plasmodium falciparum 3D7]
- gi|23509377|ref|NP_702044.1| dimethyladenosine transferase, putative [Plasmodium falciparum 3D7]
- gi|71013449|ref|XP_758591.1|_235:334 hypothetical protein UM02444.1 [Ustilago maydis 521]
- gi|46098249|gb|EAK83482.1| hypothetical protein UM02444.1 [Ustilago maydis 521]
- gi|68071473|ref|XP_677650.1|_256:354 dimethyladenosine transferase [Plasmodium berghei strain ANKA]
- gi|56497848|emb|CAH94950.1| dimethyladenosine transferase, putative [Plasmodium berghei]
- gi|82753583|ref|XP_727737.1|_229:327 dimethyladenosine transferase [Plasmodium yoelii yoelii str. 17XNL]
- gi|23483724|gb|EAA19302.1| dimethyladenosine transferase, putative [Plasmodium yoelii yoelii]
- gi|70953687|ref|XP_745929.1|_256:354 Plasmodium chabaudi chabaudi dimethyladenosine transferase [Plasmodium chabaudi chabaudi]
- gi|56526401|emb|CAH78914.1| dimethyladenosine transferase, putative [Plasmodium chabaudi]
- gi|90306003|gb|EAS35634.1|_186:346 hypothetical protein CIMG_00988 [Coccidioides immitis RS]
- gi|20803714|emb|CAA87382.2|_209:307 Hypothetical protein E02H1.1 [Caenorhabditis elegans]
- gi|25146882|ref|NP_496061.2| E02H1.1 [Caenorhabditis elegans]
- gi|27808654|sp|Q09522|DIMI_CAEEL Probable dimethyladenosine transferase (S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Taxonomy]
- gi|1806115|emb|CAA92586.1|_216:320 dimethylase [Kluyveromyces lactis]
- gi|66810281|ref|XP_638864.1|_214:314 hypothetical protein DDB0185676 [Dictyostelium discoideum]
- gi|60467487|gb|EAL65509.1| hypothetical protein DDBDRAFT_0185676 [Dictyostelium discoideum AX4]
- gi|65304135|emb|CAI76514.1|_253:351 dimethyladenosine transferase, putative [Theileria annulata]
- gi|84996835|ref|XP_953139.1| dimethyladenosine transferase [Theileria annulata strain Ankara]
- gi|37531758|ref|NP_920181.1|_89:233 putative dimethyladenosine transferse [Oryza sativa (japonica cultivar-group)]
- gi|21321758|gb|AAM47293.1| Putative dimethyladenosine transferse [Oryza sativa (japonica cultivar-group)]
- gi|18657022|gb|AAL78109.1| Putative dimethyladenosine transferse [Oryza sativa]
- gi|31430574|gb|AAP52468.1| hypothetical protein LOC_Os10g10440 [Oryza sativa (japonica cultivar-group)]
- gi|71028934|ref|XP_764110.1|_264:362 dimethyladenosine transferase [Theileria parva strain Muguga]
- gi|68351064|gb|EAN31827.1| dimethyladenosine transferase, putative [Theileria parva]
- gi|4572637|emb|CAA92585.1|_209:306 dimethylase [Schizosaccharomyces pombe]
- gi|11256767|pir||T43249 rRNA (adenine-N6,N6-)-dimethyltransferase (EC 2.1.1.-) - fission yeast (Schizosaccharomyces pombe) [Taxonomy]
- gi|39975205|ref|XP_368993.1|_229:390 hypothetical protein MG00251.4 [Magnaporthe grisea 70-15]
- gi|89308905|gb|EAS06893.1|_174:345 dimethyladenosine transferase family protein [Tetrahymena thermophila SB210]
- gi|85099447|ref|XP_960790.1|_225:398 hypothetical protein [Neurospora crassa OR74A]
- gi|32421833|ref|XP_331360.1| hypothetical protein [Neurospora crassa]
- gi|28922314|gb|EAA31554.1| hypothetical protein [Neurospora crassa]
- gi|50057288|emb|CAH03272.1|_197:353 Ribosomal RNA adenine dimethylase, putative [Paramecium tetraurelia]
- gi|50404911|ref|YP_054003.1| Ribosomal RNA adenine dimethylase, putative [Paramecium tetraurelia]
- gi|67525711|ref|XP_660917.1|_227:403 hypothetical protein AN3313.2 [Aspergillus nidulans FGSC A4]
- gi|40744101|gb|EAA63281.1| hypothetical protein AN3313.2 [Aspergillus nidulans FGSC A4]
- gi|15226591|ref|NP_182264.1|_213:353 S-adenosylmethionine-dependent methyltransferase/ rRNA (adenine-N6,N6-)-dimethyltransferase/ rRNA methyltransferase [Arabidopsis thaliana]
- gi|21280901|gb|AAM44912.1| putative dimethyladenosine transferase [Arabidopsis thaliana]
- gi|14532650|gb|AAK64053.1| putative dimethyladenosine transferase [Arabidopsis thaliana]
- gi|2529685|gb|AAC62868.1| putative dimethyladenosine transferase [Arabidopsis thaliana]
- gi|70987085|ref|XP_749024.1|_222:392 dimethyladenosine transferase [Aspergillus fumigatus Af293]
- gi|66846654|gb|EAL86986.1| dimethyladenosine transferase [Aspergillus fumigatus Af293]
- gi|32398681|emb|CAD98641.1|_241:340 dimethyladenosine transferase, probable [Cryptosporidium parvum]
- gi|66475300|ref|XP_627466.1| Dim1p-like ERMB/KSGA methylase [Cryptosporidium parvum Iowa II]
- gi|46228931|gb|EAK89780.1| Dim1p-like ERMB/KSGA methylase [Cryptosporidium parvum]
- gi|83765282|dbj|BAE55425.1|_223:392 unnamed protein product [Aspergillus oryzae]
- gi|71656161|ref|XP_816632.1|_246:344 ribosomal RNA adenine dimethylase family protein [Trypanosoma cruzi]
- gi|70881773|gb|EAN94781.1| ribosomal RNA adenine dimethylase family protein, putative [Trypanosoma cruzi]
- gi|71425341|ref|XP_813086.1|_246:344 ribosomal RNA adenine dimethylase family protein [Trypanosoma cruzi]
- gi|70877938|gb|EAN91235.1| ribosomal RNA adenine dimethylase family protein, putative [Trypanosoma cruzi]
- gi|62359277|gb|AAX79719.1|_246:344 ribosomal RNA adenine dimethylase family protein, conserved [Trypanosoma brucei]
- gi|70801818|gb|AAZ11724.1| ribosomal RNA adenine dimethylase family protein, conserved [Trypanosoma brucei]
- gi|71752811|ref|XP_825820.1| ribosomal RNA adenine dimethylase family protein, conserved [Trypanosoma brucei TREU927]
- gi|7498306|pir||T20417_204:303 hypothetical protein E02H1.1 - Caenorhabditis elegans [Taxonomy]
- gi|67464821|ref|XP_648602.1|_197:295 dimethyladenosine transferase [Entamoeba histolytica HM-1:IMSS]
- gi|56464806|gb|EAL43214.1| dimethyladenosine transferase, putative [Entamoeba histolytica HM-1:IMSS]
- gi|68127680|emb|CAJ05804.1|_255:374 ribosomal RNA adenine dimethylase family protein, putative [Leishmania major]
- gi|46121341|ref|XP_385225.1|_217:346 hypothetical protein FG05049.1 [Gibberella zeae PH-1]
- gi|42551545|gb|EAA74388.1| hypothetical protein FG05049.1 [Gibberella zeae PH-1]
- gi|42573814|ref|NP_975003.1|_248:369 S-adenosylmethionine-dependent methyltransferase/ rRNA (adenine-N6,N6-)-dimethyltransferase/ rRNA methyltransferase [Arabidopsis thaliana]
- gi|30698221|ref|NP_201437.2|_220:341 S-adenosylmethionine-dependent methyltransferase/ rRNA (adenine-N6,N6-)-dimethyltransferase/ rRNA methyltransferase [Arabidopsis thaliana]
- gi|31711838|gb|AAP68275.1| At5g66360 [Arabidopsis thaliana]
- gi|21539437|gb|AAM53271.1| dimethyladenosine transferase-like protein [Arabidopsis thaliana]
- gi|71078547|ref|XP_778360.1|_195:315 dimethylase [Giardia lamblia ATCC 50803]
- gi|29246610|gb|EAA38200.1| GLP_13_6796_7746 [Giardia lamblia ATCC 50803]
- gi|47157009|gb|AAT12376.1|_134:219 putative dimethyladenosine transferase-like protein [Antonospora locustae]
- gi|19074123|ref|NP_584729.1|_190:277 DIMETHYLADENOSINE TRANSFERASE [Encephalitozoon cuniculi GB-M1]
- gi|19068765|emb|CAD25233.1| DIMETHYLADENOSINE TRANSFERASE [Encephalitozoon cuniculi GB-M1]
- gi|12803983|gb|AAH02841.1|_215:274 HSA9761 protein [Homo sapiens]
- gi|50937619|ref|XP_478337.1|_126:261 Ribosomal RNA adenine dimethylase-like protein [Oryza sativa (japonica cultivar-group)]
- gi|34394642|dbj|BAC83949.1| Ribosomal RNA adenine dimethylase-like protein [Oryza sativa (japonica cultivar-group)]
- gi|50761519|ref|XP_424746.1|_365:416 PREDICTED: similar to HSA9761 protein [Gallus gallus]
- gi|76163024|gb|AAX30781.2|_1:92 SJCHGC07661 protein [Schistosoma japonicum]

                         10        20          30                40    
                         |         |           |                 |    
   1 .....S..S.F...LTNFDEWDNLLRICFSRKRKTLHA.IF.KRN.AVLNM..LE.....HNYKN
   2 knp..P..P.P...I-NFQEWDGLVRIAFVRKNKTLSA.AF.KSS.AVEQL..LE.....KNYRI
   3 knp..P..P.P...I-NFQEWDGLVRIAFVRKNKTLAA.SF.KST.AVQEL..LE.....KNYRI
   4 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
   5 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
   6 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
   7 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
   8 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
   9 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
  10 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
  11 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
  12 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
  13 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
  14 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
  15 rnp..P..P.P...I-NFQEWDGLVRIAFVRKNKTLSA.AF.RNK.GVVEM..LE.....KNYRV
  16 rnp..P..P.P...I-NYQEWDGLTRIAFVRKNKTLSA.AF.KQT.TVLTM..LE.....KNYKL
  17 rnp..P..P.P...I-SYTEWDGLTRIAFSRKNKTLGA.AF.RQS.VVLAT..LE.....KNYKS
  18 knp..P..P.P...V-NFQEWDGLVRIAFVRKNKMLSA.AF.KSA.AVEKL..LE.....KNYKI
  19 knp..P..P.P...V-NFTEWDGLTRIAFLRKNKTLAA.TF.KVT.SVLEM..LE.....KNYKL
  20 knp..P..P.P...V-NFTEWDGLTRIAFLRKNKTLAA.TF.KVS.SVIEM..LE.....KNYKV
  21 knp..P..P.P...L-AFEEWDGLLRIVFLRKNKTIGA.CF.KTS.SIIEM..VE.....NNYRT
  22 knp..R..P.Q...I-DFNEWDGLLRIVFVRKNRTISA.GF.KST.TVLEI..LE.....KNYKT
  23 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
  24 knp..R..P.Q...V-DYNEWDGLLRIVFVRKNRTISA.GF.KST.TVMDI..LE.....KNYKT
  25 rnp..P..P.P...I-NYTEWDGLTRIAFLRKNKTLAA.AF.KQT.TVLTT..LE.....DNFKL
  26 ktp..R..P.P...V-DFNEWDGLLRIVFVRKNRTISA.GF.KST.AVLEI..ME.....KNYKA
  27 kvp..R..P.N...I-DFNEWDGLLRICFVRKNKTIAA.GF.KSN.NILDI..LE.....KNYKT
  28 rdp..P..P.P...V-KFEEFDGLNRIIFSRANKTLRA.GF.KAK.GVVEL..LE.....KNYRT
  29 knp..R..P.N...I-DFNEWDGLLRIVFVRKNKTIAA.GF.KSS.NVIEI..LE.....KNYKT
  30 knp..R..P.Q...V-DFNEWDGLLRIVFVRKNRTIAA.GF.KST.TVLEI..LE.....KNYKA
  31 knp..R..P.P...I-DFNEWDGLLRVCFVRKNKTINA.GF.KTS.AVLAV..LE.....KNYQT
  32 knp..P..P.P...V-NFVEWEGLLRLCFMRKNKTLLA.IF.RLS.NVIEV..IE.....DNYRK
  33 p....K..E.Ssf.LTNFDEWDNLLRICFSRKRKTLHA.IF.KRN.AVLNM..LE.....HNYKN
  34 plnp.P..P.A...I-PFEEFDGLTRIVFSRRNKTVRAsFF.DAR.GVIDM..LE.....SNYKT
  35 p....K..E.NnsmI-NFDEWDNLLRICFSRKRKTLHA.IF.KRN.AVLNM..LE.....HNYKN
  36 p....K..E.NnsmI-NFDEWDNLLRICFSRKRKTLHA.IF.KRN.AVLNM..LE.....HNYKN
  37 p....K..E.NnsmI-NFDEWDNLLRICFSRKRKTLHA.IF.KRN.AVLNM..LE.....HNYKN
  38 ktp..R..P.D...I-SYDEWDGLLRIAFVRKNKTLRS.SFlGTS.SVLSM..LE.....SNYTT
  39 knp..P..P.P...V-NFVEWEGLLRLCFMRKNKTLMA.IF.RLS.NVIEV..IE.....DNFRK
  40 knp..R..P.Q...V-DFNEWDGLLRIVFVRKNRTIAA.GF.KST.TDLEI..LE.....KNYKA
  41 fnp..P..P.P...I-NFVEWDGLVKLCFSRKNKTLSG.IF.RVS.SVIET..LN.....QNYKT
  42 p....RqqPlV...V-DFGEWDGMIRICFSRKRRTLRS.LF.KKQ.SVLSI..LE.....SNYKS
  43 rkp..L..P.P...V-SFKEWDGLVRLCFNRKNKTLGA.IF.KQK.RVLEL..LE.....KNYKT
  44 p....ReqPlV...V-DFGEWDGMIRICFSRKRRTLRS.LF.KKQ.SVLSI..LE.....SNYKS
  45 knp..P..P.P...L-AFEEWDGLLRIVFLRKNKTIGA.CF.KTS.SIIEM..VE.....NNYRT
  46 gre..R..P.N...V-SWEEWDGMLRVCFNRKNKTLHA.SFlGVK.EVLAM..AE.....RNYKV
  47 epknpA..P.V...L-NYIEWDGLLRVCFMRKNKQLSA.IF.KNK.SVLQV..LE.....KNFET
  48 gsa..R..P.N...I-AFEEFDGLLRIAFNRKNKTLYA.GF.NQK.EVLNM..CE.....RNYKV
  49 knp..I..P.N...I-NYIEWDGLLRICFNRKNKQLSA.IF.KNK.SVLKT..LE.....HNFHV
  50 klg..K..P.E...I-SWDEWDGMLRICFVRKNKTLRA.GF.MAT.KIRQM..IE.....RNWIT
  51 rrp..G..P.Q...V-NKKEWDGFLRVCFIRKNKTLGS.IF.KQK.SVLSM..LE.....KNFKT
  52 kad..R..P.N...I-SWDEWDGMLRICFVRKNKTLRA.GF.MAT.KVRAL..IE.....RNWIT
  53 p....KkiPvS...V-NFREWDGLMRICFSRKKKTIRA.NF.NNS.SVLNI..LE.....NNYKV
  54 ksd..R..P.A...I-SWDEWDGMLRICFVRKNKTLRA.GF.MGN.KTRAM..IE.....RNWIT
  55 khp..A..P.D...V-DFEEWDGLVKFIFNRKNKKVSS.IF.RTK.NAVQT..LY.....EKYCS
  56 khp..A..P.D...V-DFEEWDGLVKFIFNRKNKKVSS.IF.RTK.NAVQT..LY.....EKYCS
  57 khp..A..P.S...V-DFEEWDGLVKHIFNRKNKKVSS.IF.RTK.NTVRT..LY.....DKYCS
  58 vr7knP..P.P...----PEWEGLLRLCFMRKNKTLMA.IF.RLS.NVIEV..IE.....DNFRK
  59 vkp..A..P.P...L-NLVEFDGFLRICFLRKHKTLSS.LF.RIS.SVLEV..ME.....KNLRI
  60 kyp..P..P.D...V-DFEEWDGLVKMLFSRKNKKSSS.IF.RTK.AAAQA..LY.....DKYVS
  61 rtd..V..P.A...V-GLEELDGVLRICFSRKNKTLRA.SF.LDS.H--EI..CE.....RNWIT
  62 kei..I..P.D...V-NVQEWLAFTRTCFGKKNKTLGS.MF.RQKkKVMELqsLSagrhgSNVEV
  63 kei..I..P.D...V-NVQEWLAFTRTCFGKKNKTLGS.MF.RQKkKVMELqsLSagrhgSNVEV
  64 vgp..P..P.G...L-DLDEFNGLTRILFSKKNKTLGA.IF.KTK.SLLDD..LA.....NNIAR
  65 rvp..R..P.P...I-NIEEFNRLLKICFLRKNKRLSG.IF.KRT.VIQDM..--.....-----
  66 rip..R..P.P...I-DLGEFDRFLKICFLRKNKTLRA.NF.KNS.SLVSK..IK.....ND---
  67 knp..P..P.P...I-NFQEWDGLVRITFVRKNKTLSA.AF.KSS.AVQQL..LE.....KNYRI
  68 raa..E..P.N...V-DLAEWLAFTRSCFGQKNKTLGA.IF.KQKrKVLEL..FR.....RSRCA
  69 knp..P..P.P...I-NFQEWDGLVRIAFVRKNKTLSA.AF.KSS.AVEQL..LD.....HNYRI
  70 .....-..-.-...-----EWDGLLRLVFARKNKTIGA.NL.GGK.SIASH..LR.....KIYME


             50                    60         70        80        90   
             |                     |          |         |         |   
   1 WC.TL..NK.QV.PV.N..F..P.....FKKYCLDVLE.HLDMCEKRSINLDENDFLKLLLEFNK
   2 HC.SLh.NV.TI.PA.D..F..S.....IAKKIEGVLQ.EASFCEKRARSMDIDDFMVLLHAFNS
   3 HC.SLh.NI.SV.PE.N..F..S.....IAEKIEGILT.ETGFSEKRARSMDIDDFMALLHGFNS
   4 HC.SVh.NI.II.PE.D..F..S.....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNA
   5 HC.SVh.NI.II.PE.D..F..S.....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNA
   6 HC.SVh.NI.II.PE.D..F..S.....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNA
   7 HC.SVh.NI.II.PE.D..F..S.....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNA
   8 HC.SVh.NI.II.PE.D..F..S.....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNA
   9 HC.SVh.NI.II.PE.D..F..S.....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNA
  10 HC.SVh.NI.II.PE.D..F..S.....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNA
  11 HC.SVq.NT.VI.PE.D..F..S.....IADKIQQILT.NTGFSDKRARSMDIDDFIRLLHGFNA
  12 HC.SVq.NT.VI.PE.D..F..S.....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNA
  13 HC.SVq.NT.VI.PE.D..F..S.....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNA
  14 HC.SVq.NT.VI.PE.D..F..S.....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNA
  15 HC.SVk.NI.AI.PD.N..L..D.....MKEKVVSVLE.KIEFEGKRARTMDIDDFLKLLSSFNT
  16 HC.SLn.NK.II.TE.G..F..N.....IKDMISDILQ.KADAENKRARTMDIDDFISLLHAFNA
  17 FC.SVn.NK.EI.PP.G..F..N.....IKEKVEQVLK.QVEGDQKRARTMDIDDFMVLLHAFNS
  18 HC.SVh.NI.EI.PE.D..F..N.....IAPKIESILQ.ESKFSDKRARSMDIDDFMVLLHAFNS
  19 YR.SLr.NE.PI.ED.D..F..K.....MQDKVISILE.EQDMAAKRARSMDIDDFMRLLLAFNS
  20 FR.SLr.NE.PL.EE.G..F..N.....MQEKVIGILE.ELEMATLRARSMDIDDFMRLLRAFNS
  21 WC.SQ..NErMV.EE.D..F..D.....VKSLIDGVLQ.QCNLQDARASKCGQTEFLSLLHAFHQ
  22 FL.AI..NN.QS.ID.E..T..EnlqslIKQKIETVLK.ETGLAEKRAGKCDQTDFLKLLYAFHQ
  23 HC.SVh.NI.II.PE.D..F..S.....IADKIQQILT.STGFSDKRARSMDIDDFIRLLHGFNA
  24 FL.AM..NN.EM.VD.D..T..Kgs6dvVKEKIDTVLK.ETDLGDKRAGKCDQNDFLRLLYAFHQ
  25 HC.SLk.NI.DV.PA.D..L..N.....VKEMVEKILE.KADASDKRARSMDIDDFMAVLQAFNA
  26 YL.ATt.ND.AM.VD.D..A..Kgs6eqVKQKIETVLA.ETGLSDKRAGKCDQTDFLKLLYAFHQ
  27 FL.STa.NA.AA.NG.D..D..Sm12diVKAKIEQVLT.ETGFSDKRAAKLDQTDFLKLLYAFHQ
  28 WCaEQ..GA.II.ED.N..F..D.....IREKVESILV.ETGFADSRAAKMDVDDLLKLLAAFNV
  29 FL.AT..QE.SN.NN.D..S..Mm12dvVKNKITTVLT.ETGFSDKRAGKLDQTDFLKLLYAFHQ
  30 FL.AT..QS.AV.PT.T..S..Sgd7neVKEKIEQVLS.ETGLAEKRAGKCDQTDFLKLLYGFHQ
  31 WL.STq.GE.II.PE.G..S..Nlsdv.VKQKINKILT.DTGIGEMRSAKCDQTEFLTLLNEFHK
  32 VC.SMk.NK.PL.PK.D..F..N.....MKKLIEETLT.ASGYAENRARKMRVEDFLALLLAFNK
  33 WC.TL..NK.QV.PV.N..F..P.....FKKYCLDVLE.HLDMCEKRSINLDENDFLKLLLEFNK
  34 YC.AV..KE.IM.PE.Q..G..S.....FADMVKQVLV.ETGSAENRAAKMDIDDLLTLLAAFHE
  35 YC.TF..NK.II.PI.N..Y..S.....FKTFCLDTLK.DLEMEEQRSINLDENDFLKLLLEFNK
  36 YC.TF..NK.IV.PI.N..Y..S.....FKTFCLDTLK.DLEMEEQRSINLDENDFLKLLLEFNK
  37 YC.TF..NK.IV.PI.N..Y..S.....FKTFCLDTLK.DLEMEEQRSINLDENDFLKLLLEFNK
  38 WC.AQ..ND.-I.PV.E..V..Gp62klVRKKVRQVLEdDTGLADKRARMCDEGDFLKLLWSFNQ
  39 VC.SFk.NK.PI.PK.D..L..N.....MKKVIEETLT.ASGYGESRARKMRVEDFLALLLAFNK
  40 FL.AT..QS.AV.PT.T..S..Sgd7neVKEKIEQVLS.ETGLAEKRAGKCDQTDFLKLLYGFHQ
  41 YC.AL..EG.KM.NT.D..G..Sdeq..MKELIIKTLT.DNDFLDSRSSKLDINDFLKLLNKFHE
  42 WC.TI..NN.KV.PV.Y..K..P.....FKEFVIEILE.SSGLAERRSITVSIAEFLKLLLAFNE
  43 MQ.SL..QL.TS.DA.E..K..Ge47acFKEKIMGILQ.QGDFAEKRASKLSQVDFLYLLSLFNK
  44 WC.TI..NN.KV.PV.V..K..P.....FKEFVIEILE.GSGLAERRSITVSIAEFLKLLLAFNE
  45 WC.SQ..NErMV.EE.D..F..D.....VKSLIDGVLQ.QCNLQDARASKCGQQS-LSLLHPFHQ
  46 WC.TM..ND.-I.PI.D..E..Sv64elVRSKIEKVLK.DTDLAEQRANKCDQNDFLRLLAAFNA
  47 YQ.KI..KA.IE.QG.A..V..Ee72klFKEKIHKILE.DSGYLEKRPAKLDIDDYLKLLFVFNQ
  48 YC.TL..NN.-I.PI.D..E..Sl77liVKAKLNKVLT.STGLADKRARQCDQNDFLKLLLAFHE
  49 IE.QE..GI.KV.ND.P..A..Nn59npFRLKINEILK.TNDMFQKRPVKMDNDDFLQLLCAMNA
  50 WA.AMhpEK.VS.QG.D..V..Dl77rlIQFKIERILD.TAGLANHRANKCDENDFLRLLHACNT
  51 LQ.AV..LA.SL.QN.N..G..Ep43seFKEKVMNVLK.EGGFEEKRSSKLSQQEFLYLLSLFNK
  52 WV.SMhpEK.VT.QA.D..I..Df71klVQAKIQRVLE.QTNLANARAQKCDENNFLRLLHGFNT
  53 WS.SI..NQ.KD.PCgN..M..P.....FKTFIFKILE.DSGLSSKRGFNVDINEYFRLLFEFNK
  54 FA.TMypEK.VT.QA.D..I..Df70klIQVKLQRILD.RTELANARAQKCDENDFLRLLHACNK
  55 YQ.KM..EG.KT.SV.KslA..E.....FKEHLETVMQ.D-PVFESRARLLDQDSITKLLCHFTE
  56 YQ.KM..EG.KT.SV.KslA..E.....FKEHLETVMQ.D-PVFESRARLLDQDSITKLLCHFTE
  57 YQ.RM..EG.VK.DV.K..TfeE.....FRQHLESILQ.E-PIFDKRARVLDQESIMELLCCFTK
  58 VC.SFk.NK.PI.PK.D..L..N.....MKKVIEETLT.ASGYGESRARKMRVEDFLALLLAFNK
  59 IA.KIr.NI.PI.DE.N..L..D.....VKADVLQILE.ESGRAKSRAAQLTLDDFLELIYAFMK
  60 YR.KM..EG.GQ.PV.G..T..At23eqFRVLLAAVIA.D-PMFEQRSRMLDEVALMTMLAHFIK
  61 WT.SMypDK.VS.EK.D..L..Dl32nlIRTKIEHVLE.TTELAEARAVKCDENDFLKLILAFRE
  62 MN.QT..GG.DS.DS.D..V..Ee16smFKERVIEILR.TNGFEEKRPSKLSHRELLHLLSLFNQ
  63 MN.QT..GG.DS.DS.D..V..Ee16smFKERVIEILR.TNGFEEKRPSKLSHRELLHLLSLFNQ
  64 LD.EI..SR.LHkPA.Q..H..Eg22vqLRERIAEALA.EANLTDTRPNHMAIPDLLSLMCALAA
  65 -Q.KV..NK.AY.TL.Q..-..E.....IEKKTTGILR.KLGA--DRAAKMDIEDFLFLLLEFKK
  66 -P.NF..EN.TT.PD.D..V..-.....----FERVLS.GADLAGARAAKMDLDDFLALLLEFRK
  67 HC.SV..HN.IV.SA.Av.Y..P.....VKQI------.--------------------------
  68 EE.RC..DG.NA.NA.G..G..Gs37avFKAKITGALE.SCELAGKRPSKLSNDELLRLLKLLNE
  69 HC.SL..HN.AV.SS.F..L..-.....----------.--------------------------
  70 TC.CT..KG.LS.PT.P..E..Vi10vaMEEKISSILR.DSGFEKKRARTLDEDDFLRLLLAQTI


                  
                 
   1 K...GIHFF...
   2 A...GIHFS...
   3 Q...GIHFT...
   4 E...GIHFS...
   5 E...GIHFS...
   6 E...GIHFS...
   7 E...GIHFS...
   8 E...GIHFS...
   9 E...GIHFS...
  10 E...GIHFS...
  11 E...GIHFS...
  12 E...GIHFS...
  13 E...GIHFS...
  14 E...GIHFS...
  15 E...GIHFS...
  16 K...GVHFI...
  17 E...GIHFS...
  18 A...GIHFS...
  19 A...GIHFN...
  20 K...GIHFN...
  21 V...GVHFA...
  22 V...GIHFS...
  23 EvsvTIAYLfry
  24 V...GIHFS...
  25 E...GFHFS...
  26 V...GLHFS...
  27 V...GLHFA...
  28 E...GIHFA...
  29 V...GIHFA...
  30 V...GIHFA...
  31 A...GIYFA...
  32 A...DIHFLs..
  33 K...GIHFFnis
  34 K...GIHFS...
  35 K...GIRFFnia
  36 K...GIRFFnia
  37 K...GIRFFnia
  38 R...GIHFN...
  39 A...DIHFLs..
  40 V...GIHFA...
  41 T...GIHFK...
  42 V...GIHFCnia
  43 A...GIHFS...
  44 V...GIHFCnia
  45 V...GRSFWlmg
  46 E...GIHFA...
  47 N...EIHFK...
  48 E...GIHFS...
  49 Q...GIHFK...
  50 E...GIHFS...
  51 S...GIHFT...
  52 E...GIHFS...
  53 N...GVHFVnii
  54 E...GIHFS...
  55 N...GIHFV...
  56 N...GIHFV...
  57 N...DIHFV...
  58 A...DIHFLs..
  59 K...NYHFC...
  60 H...GIHFI...
  61 N...NIYFT...
  62 A...GIFFHdit
  63 A...GIFFHdit
  64 K...GVRFTn..
  65 E...GISF-...
  66 V...NIYF-...
  67 -...-----...
  68 Q...GVRFQ...
  69 -...-----...
  70 -...-----...