a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0289
- gi|55729784|emb|CAH91620.1|_216:313 hypothetical protein [Pongo pygmaeus]
- gi|55731304|emb|CAH92366.1|_216:313 hypothetical protein [Pongo pygmaeus]
- gi|52782193|dbj|BAD51943.1|_216:312 aspartoacylase [Macaca fascicularis]
- gi|62510428|sp|Q60HH2|ACY2_MACFA Aspartoacylase (Aminoacylase-2) (ACY-2) [Taxonomy]
- gi|19354304|gb|AAH24934.1|_215:311 Aspartoacylase (aminoacylase) 2 [Mus musculus]
- gi|34395504|sp|Q8R3P0|ACY2_MOUSE Aspartoacylase (Aminoacylase-2) (ACY-2) [Taxonomy]
- gi|50926810|gb|AAH78814.1|_215:311 Aspa protein [Rattus norvegicus]
- gi|50925483|gb|AAH78813.1| Aspa protein [Rattus norvegicus]
- gi|73967285|ref|XP_854515.1|_216:312 PREDICTED: similar to Aspartoacylase (Aminoacylase-2) (ACY-2) isoform 1 [Canis familiaris]
- gi|56206682|emb|CAI24567.1|_215:311 aspartoacylase (aminoacylase) 2 [Mus musculus]
- gi|12833153|dbj|BAB22412.1| unnamed protein product [Mus musculus]
- gi|31560279|ref|NP_075602.2| aspartoacylase (aminoacylase) 2 [Mus musculus]
- gi|12842492|dbj|BAB25624.1|_215:311 unnamed protein product [Mus musculus]
- gi|8570166|gb|AAF76459.1|_215:310 aspartoacylase ASPA [Mus musculus]
- gi|1168339|sp|P46446|ACY2_BOVIN_216:312 Aspartoacylase (Aminoacylase-2) (ACY-2) [Taxonomy]
- gi|76664250|ref|XP_586387.2|_216:312 PREDICTED: similar to Aspartoacylase (Aminoacylase-2) (ACY-2) [Bos taurus]
- gi|4557335|ref|NP_000040.1|_216:312 aspartoacylase [Homo sapiens]
- gi|20810518|gb|AAH29128.1| Aspartoacylase [Homo sapiens]
- gi|49456771|emb|CAG46706.1| ASPA [Homo sapiens]
- gi|455834|gb|AAB29190.1| aspartoacylase; ASP [Homo sapiens]
- gi|1168340|sp|P45381|ACY2_HUMAN Aspartoacylase (Aminoacylase-2) (ACY-2) [Taxonomy]
- gi|60834485|gb|AAX37096.1|_216:312 aspartoacylase [synthetic construct]
- gi|50758298|ref|XP_415853.1|_416:510 PREDICTED: similar to Aspartoacylase (Aminoacylase-2) (ACY-2) [Gallus gallus]
- gi|13242314|ref|NP_077375.1|_215:313 aspartoacylase [Rattus norvegicus]
- gi|34395488|sp|Q9R1T5|ACY2_RAT Aspartoacylase (Aminoacylase-2) (ACY-2) [Taxonomy]
- gi|5689082|dbj|BAA82801.1| aspartoacylase [Rattus norvegicus]
- gi|73967287|ref|XP_868535.1|_216:314 PREDICTED: similar to Aspartoacylase (Aminoacylase-2) (ACY-2) isoform 2 [Canis familiaris]
- gi|89268929|emb|CAJ82275.1|_215:310 aspartoacylase (aminoacylase 2, Canavan disease) [Xenopus tropicalis]
- gi|68361632|ref|XP_685336.1|_218:309 PREDICTED: similar to Aspartoacylase (Aminoacylase-2) (ACY-2), partial [Danio rerio]
- gi|47227041|emb|CAG00403.1|_379:465 unnamed protein product [Tetraodon nigroviridis]
- gi|21309896|gb|AAM46090.1|_217:305 hepatitis C virus core-binding protein 1 [Mus musculus]
- gi|12832094|dbj|BAB21963.1| unnamed protein product [Mus musculus]
- gi|27373032|gb|AAN87897.1| acylase III [Mus musculus]
- gi|14789807|gb|AAH10795.1|_217:305 Aspartoacylase-3 [Mus musculus]
- gi|31982632|ref|NP_082133.2| aspartoacylase-3 [Mus musculus]
- gi|21654858|gb|AAK94771.1| aspartoacylase-3 [Mus musculus]
- gi|19880023|gb|AAM00225.1| aspartoacylase-3 [Mus musculus]
- gi|19880021|gb|AAM00224.1| aspartoacylase-3 [Mus musculus]
- gi|74150866|dbj|BAE25538.1| unnamed protein product [Mus musculus]
- gi|34395505|sp|Q91XE4|ACY3_MOUSE Aspartoacylase-2 (Aminoacylase-3) (ACY-3) (Acylase III) (Hepatitis C virus core-binding protein 1) (HCBP1) [Taxonomy]
- gi|55636525|ref|XP_508599.1|_194:284 PREDICTED: similar to aspartoacylase (aminocyclase) 3; HCV core-binding protein; aspartoacylase-3 [Pan troglodytes]
- gi|17133046|dbj|BAB75611.1|_207:290 aspartoacylase [Nostoc sp. PCC 7120]
- gi|17231404|ref|NP_487952.1| aspartoacylase [Nostoc sp. PCC 7120]
- gi|34395523|sp|Q8YQC1|ASPA_ANASP Probable aspartoacylase [Taxonomy]
- gi|14250495|gb|AAH08689.1|_218:308 Aspartoacylase (aminocyclase) 3 [Homo sapiens]
- gi|18087825|ref|NP_542389.1| aspartoacylase (aminocyclase) 3 [Homo sapiens]
- gi|21654856|gb|AAK94770.1| aspartoacylase-3 [Homo sapiens]
- gi|27373030|gb|AAN87896.1| acylase III [Homo sapiens]
- gi|34395507|sp|Q96HD9|ACY3_HUMAN Aspartoacylase-2 (Aminoacylase-3) (ACY-3) (Acylase III) (Hepatitis C virus core-binding protein 1) (HCBP1) [Taxonomy]
- gi|56789470|gb|AAH88190.1|_218:307 Aspartoacylase-3 [Rattus norvegicus]
- gi|57526957|ref|NP_001009603.1| aspartoacylase-3 [Rattus norvegicus]
- gi|75701731|gb|ABA21407.1|_207:290 Succinylglutamate desuccinylase/aspartoacylase [Anabaena variabilis ATCC 29413]
- gi|75908006|ref|YP_322302.1| aspartoacylase [Anabaena variabilis ATCC 29413]
- gi|71676004|ref|ZP_00673747.1|_206:289 Aspartoacylase [Trichodesmium erythraeum IMS101]
- gi|71670865|gb|EAO27532.1| Aspartoacylase [Trichodesmium erythraeum IMS101]
- gi|60551902|gb|AAH91576.1|_217:304 MGC97491 protein [Xenopus tropicalis]
- gi|71896001|ref|NP_001025627.1| MGC97491 protein [Xenopus tropicalis]
- gi|33635387|emb|CAE21712.1|_202:290 putative aspartoacylase [Prochlorococcus marinus str. MIT 9313]
- gi|33863804|ref|NP_895364.1| aspartoacylase [Prochlorococcus marinus str. MIT 9313]
- gi|46576457|sp|Q7V5L6|ASPA_PROMM Probable aspartoacylase [Taxonomy]
- gi|86438101|gb|AAI12800.1|_216:290 MGC137381 protein [Bos taurus]
- gi|33633723|emb|CAE18681.1|_197:286 putative aspartoacylase [Prochlorococcus marinus subsp. pastoris str. CCMP1986]
- gi|33860781|ref|NP_892342.1| aspartoacylase [Prochlorococcus marinus subsp. pastoris str. CCMP1986]
- gi|34395518|sp|P59830|ASPA_PROMP Probable aspartoacylase [Taxonomy]
- gi|72003277|gb|AAZ59079.1|_202:291 aspartoacylase [Prochlorococcus marinus str. NATL2A]
- gi|72383427|ref|YP_292782.1| aspartoacylase [Prochlorococcus marinus str. NATL2A]
- gi|88807290|ref|ZP_01122802.1|_206:294 aspartoacylase [Synechococcus sp. WH 7805]
- gi|88788504|gb|EAR19659.1| aspartoacylase [Synechococcus sp. WH 7805]
- gi|23127342|ref|ZP_00109215.1|_209:290 COG2988: Succinylglutamate desuccinylase [Nostoc punctiforme PCC 73102]
- gi|90578042|ref|ZP_01233853.1|_206:292 aspartoacylase [Vibrio angustum S14]
- gi|90441128|gb|EAS66308.1| aspartoacylase [Vibrio angustum S14]
- gi|89076336|ref|ZP_01162673.1|_206:292 aspartoacylase [Photobacterium sp. SKA34]
- gi|89047968|gb|EAR53558.1| aspartoacylase [Photobacterium sp. SKA34]
- gi|87125344|ref|ZP_01081190.1|_223:311 putative aspartoacylase [Synechococcus sp. RS9917]
- gi|86167113|gb|EAQ68374.1| putative aspartoacylase [Synechococcus sp. RS9917]
- gi|46915882|emb|CAG22653.1|_206:291 hypothetical protein [Photobacterium profundum SS9]
- gi|54302460|ref|YP_132453.1| aspartoacylase [Photobacterium profundum SS9]
- gi|49901251|gb|AAH75994.1|_230:321 Hypothetical protein LOC436874 [Danio rerio]
- gi|50540268|ref|NP_001002601.1| hypothetical protein LOC436874 [Danio rerio]
- gi|23124740|ref|ZP_00106710.1|_242:329 COG2988: Succinylglutamate desuccinylase [Nostoc punctiforme PCC 73102]
- gi|87301313|ref|ZP_01084154.1|_202:292 aspartoacylase [Synechococcus sp. WH 5701]
- gi|87284281|gb|EAQ76234.1| aspartoacylase [Synechococcus sp. WH 5701]
- gi|47212543|emb|CAF94992.1|_213:299 unnamed protein product [Tetraodon nigroviridis]
- gi|33237228|gb|AAP99297.1|_202:294 Succinylglutamate desuccinylase [Prochlorococcus marinus subsp. marinus str. CCMP1375]
- gi|34395519|sp|P72208|ASPA_PROMA Probable aspartoacylase [Taxonomy]
- gi|33239703|ref|NP_874645.1| aspartoacylase [Prochlorococcus marinus subsp. marinus str. CCMP1375]
- gi|90412575|ref|ZP_01220577.1|_208:291 aspartoacylase [Photobacterium profundum 3TCK]
- gi|90326383|gb|EAS42795.1| aspartoacylase [Photobacterium profundum 3TCK]
- gi|49901272|gb|AAH75914.1|_219:309 Zgc:92178 [Danio rerio]
- gi|50539762|ref|NP_001002347.1| hypothetical protein LOC436619 [Danio rerio]
- gi|89093719|ref|ZP_01166666.1|_207:294 aspartoacylase [Oceanospirillum sp. MED92]
- gi|89082115|gb|EAR61340.1| aspartoacylase [Oceanospirillum sp. MED92]
- gi|88797200|ref|ZP_01112790.1|_206:292 aspartoacylase [Reinekea sp. MED297]
- gi|88780069|gb|EAR11254.1| aspartoacylase [Reinekea sp. MED297]
- gi|1542937|emb|CAB02200.1|_202:294 aspartoacylase [Prochlorococcus marinus]
- gi|78196526|gb|ABB34291.1|_201:290 Aspartoacylase [Synechococcus sp. CC9605]
- gi|78212067|ref|YP_380846.1| aspartoacylase [Synechococcus sp. CC9605]
- gi|84518709|ref|ZP_01006058.1|_230:321 aspartoacylase [Prochlorococcus marinus str. MIT 9211]
- gi|84513458|gb|EAQ09796.1| aspartoacylase [Prochlorococcus marinus str. MIT 9211]
- gi|67920810|ref|ZP_00514329.1|_205:286 Aspartoacylase [Crocosphaera watsonii WH 8501]
- gi|67856927|gb|EAM52167.1| Aspartoacylase [Crocosphaera watsonii WH 8501]
- gi|78169679|gb|ABB26776.1|_201:291 Aspartoacylase [Synechococcus sp. CC9902]
- gi|78185385|ref|YP_377820.1| aspartoacylase [Synechococcus sp. CC9902]
- gi|33866454|ref|NP_898013.1|_201:291 aspartoacylase [Synechococcus sp. WH 8102]
- gi|33633232|emb|CAE08437.1| putative aspartoacylase [Synechococcus sp. WH 8102]
- gi|34395517|sp|P59829|ASPA_SYNPX Probable aspartoacylase [Taxonomy]
- gi|76804021|gb|ABA55964.1|_226:310 putative aspartoacylase [Vibrio sp. DAT722]
- gi|91225714|ref|ZP_01260743.1|_202:285 aspartoacylase [Vibrio alginolyticus 12G01]
- gi|91189603|gb|EAS75878.1| aspartoacylase [Vibrio alginolyticus 12G01]
- gi|78712109|gb|ABB49286.1|_202:289 Aspartoacylase [Prochlorococcus marinus str. MIT 9312]
- gi|78778610|ref|YP_396722.1| Aspartoacylase [Prochlorococcus marinus str. MIT 9312]
- gi|16329830|ref|NP_440558.1|_204:284 aspartoacylase [Synechocystis sp. PCC 6803]
- gi|1652315|dbj|BAA17238.1| aspartoacylase, ASP [Synechocystis sp. PCC 6803]
- gi|34395520|sp|P73211|ASPA_SYNY3 Probable aspartoacylase [Taxonomy]
- gi|47219983|emb|CAG11516.1|_73:155 unnamed protein product [Tetraodon nigroviridis]
- gi|94398243|ref|XP_001001236.1|_6:74 PREDICTED: similar to aspartoacylase-3 [Mus musculus]
- gi|88796549|ref|ZP_01112214.1|_207:288 aspartoacylase [Alteromonas macleodii 'Deep ecotype']
- gi|88772108|gb|EAR03408.1| aspartoacylase [Alteromonas macleodii 'Deep ecotype']
- gi|73983588|ref|XP_854611.1|_475:530 PREDICTED: similar to Aldehyde dehydrogenase 3B1 (Aldehyde dehydrogenase 7) [Canis familiaris]
- gi|31418016|gb|AAH10941.1|_216:251 ASPA protein [Homo sapiens]
- gi|55644795|ref|XP_511268.1|_216:248 PREDICTED: similar to ASPA protein [Pan troglodytes]
- gi|21654941|gb|AAK94773.1|_12:41 aspartoacylase-3 [Mus spretus]

              10        20              30            40        50     
              |         |               |             |         |     
   1 PPCAIDVYKIMEKVDYPRNE.....S.GDVAAVIHPNL..Q..DQDWKPLHPGDPVFVSLDGKVI
   2 PPCAIEVYKIIEKVDYPRDE.....N.GEIAAVIHPNL..Q..DQDWKPLHPGDPMFLTLDGKTI
   3 PPCAIEVYKIIEKVDYPRDE.....N.GEIAAVVHPNL..Q..DQDWKPLHPGDPMFLTLDGKTI
   4 PPCAIEVYKIIEKVDYPRDE.....N.GEIAAVIHPNL..Q..DQDWKPLHPGDPMFLTLDGKTM
   5 PPCSIDVYKIMEKVDYPRNE.....S.GDMAAVIHPNL..Q..DQDWKPLHPGDPVFVSLDGKVI
   6 PPCAIDVYKIMEKVDYPRNE.....S.GDVAAVIHPNL..Q..DQDWKPLHPGDPVFVSLDGKVI
   7 PPCAIEVYKIMEKVDYPRNE.....N.GDIAALIHPNL..Q..DQDWKPLHPGDPVFLTLEGKSI
   8 PPCSIDVYKIMEKVDYPRNE.....S.GDMAAVIHPNL..Q..DQDWKPLHPGDPVFVSLDGKVI
   9 PPCSIDVYKIMEKVDYPRNE.....S.GDMAAVIHPNL..Q..DQDWKPLHPGDPVFVSLDGKVI
  10 PPCSIDVYKIMEKVDYPRNE.....S.GDMAAVIHPNL..Q..DQDWKPLHPGDPVFVSLDGKVI
  11 PPCAIEVYKIMRKVDYPRNE.....S.GEISAIIHPKL..Q..DQDWKPLHPEDPVFLTLDGKTI
  12 PPCAIEVYKIMEKVDYPRNE.....S.GEISAIIHPKL..Q..DQDWKPLHPEDPVFLTLDGKTI
  13 PPCAIEVYKIIEKVDYPRDE.....N.GEIAAIIHPNL..Q..DQDWKPLHPGDPMFLTLDGKTI
  14 PPCAIEVYKIIEKVDYPRDE.....N.GEIAAIIHPNL..Q..DQDWKPLHPGDPMFLTLDGKTI
  15 PPCTIEVYKITEKVDYPRNK.....N.DEVIAIIHPNL..Q..DQDWQPLNNGDPLFLTLDGEVI
  16 PPCAIDVYKIMEKVDYPRNE.....S.GDVAAVIHPNLqlQ..DQDWKPLHPGDPVFVSLDGKVI
  17 PPCAIEVYKIMEKVDYPRNE.....N.GDIAALIHPNL..QlsDQDWKPLHPGDPVFLTLEGKSI
  18 LPCILEVFKVLDNVAYPRNA.....N.GDCTAIIHNNL..Q..DQDWNELKPGDPMFLTLDGRMI
  19 PPCTVNVFRVQERMDYPRDT.....N.GNITAMVHPHL..Q..DCDWEPLNRGDPMFLTFDGRTI
  20 --CTVEVFRVLERVDYPRDT.....N.GNIIAMVHPNL..Q..DCDWEPLTPGDPMFQTFDGKTI
  21 --FEMDIYRNLGSVDFPRTA.....D.GDLAGTVHPQL..Q..DHDFEPLRPGEPIFKLFSGEDV
  22 --FEMDIYRNLGSVDFPRTA.....D.GDLAGTVHPQL..Q..DHDFEPLRPGEPIFKLFSGEDV
  23 --FEMEAYRPVGVVDFPRTE.....A.GNLAGTVHPQL..Q..DRDFQPLQPGAPIFQMFSGEDL
  24 ----LALYKFTGTVDYPRNE.....N.GDIQGMIHPDI..Q..FRDYEPLNPGDPLFLTLDGKAI
  25 --FEMEAYRPVGVVDFPRTE.....A.GHLAGTVHPQL..Q..DRDFQPLQPGAPIFQMFSGEDL
  26 --FEMEVYKNLGSVDFPRTT.....D.GHLTGTVHSRL..Q..DHDFEPLRPGEPIFKLFSGEDV
  27 ----LSLYKFTGTIDYPRNG.....N.GDIQAMIHPDI..Q..FRDYAPLNPGDPLFLTLDGKAI
  28 --RDIVIYKHLKVVDYPKTK.....D.GEIVAMIHPQL..Q..GRDYQKLSPGEPMFLTFDNQTI
  29 ---ETDVHQVLYRADFPRNE.....D.GEIEAVIHSEL..Q..DKDYLPLKPGDPIFQRLNGEDI
  30 -PDEFVVHSHLGSLDLPRDA.....L.GQPAACVHPSL..Q..GRDWQPLQMGAPLFLWPDGEVF
  31 PPCAIEVYKIMEKVDYPRNE.....S.GEISAIIHPKL..Q..DQDWKPLHPEDPVFLTLDGKTI
  32 -PKDLFVHVHQGSIDYPRDK.....N.GNINALIHPER..I..NQDWKPIKKDAPLFMDMEGKTK
  33 -PNKLIIHRHIKSIDFPRDE.....E.GNIDGYVHSLR..Q..SKDWQELKKNDELFCKLNGEII
  34 -PDQVVIHLHLGSLDVPRRS.....S.GDPDALVHPNL..Q..GRDWQPLKAGDPLFIDAESNTV
  35 ----LILYDHLSVVDYPKQQ.....D.GKIFAMIHPEL..Q..DKDYQALNPGDPMFITFDNKTI
  36 -PASYDAYCYEETLKLPEDE.....Q.GERIGMVHQSV..Q..DNDFEPLRSGDPIFTLFDGTEI
  37 -PASYDAYCYEETLKLPVDE.....Q.GERIGMVHQSV..Q..DNDFEPLRSGDPIFTLFDGTEI
  38 -PERLVVHRHLGSLDLPRDP.....Q.GRADALIHPEL..Q..GRDWSPIRRGDPLFLTAAGDTI
  39 -PSSYEAFEYKETLKLPENE.....N.GERIGMVHKNV..Q..DGDFKQLNSGDPIFTLFDGSEI
  40 ---DVEAFKFIKSVDYPRDP.....EtRNLTAAVHPQL..Q..DRDFCLLKRGDPLFLSFSGETV
  41 ---QLTFYQYIETIDYPRSDay6lqS.GEIQAMIHPQL..Q..FKDYEPLNPGDPMFLTFAGKDI
  42 -PRGLTVHRHLGSLDLPRHP.....D.GRPAACLHPLR..Q..HRDWQVIRPGDPLFVTAGGETL
  43 ----VDVFTMVKHIDYPRER.....DtGNIIAAVHPQL..Q..DRDFCLLHPEDPLFQTFSGETL
  44 -PEQLIVHRHLKNIDFPRDS.....S.GVPSSLVHKDI..Q..GRDWYPIKNGHPLFESLSGDLT
  45 ---SYEAFEYTETLKLPENE.....N.GERIGMVHKNV..Q..DGDFKQLNSGDPIFTLFDGSEI
  46 ---DVEAFKIIKSVDYPRDPv....T.RSLNAAVHPQL..Q..DRDFCLLKRGDPLFLSFSGETV
  47 -PMQMGGYRFTKKIRLPENE.....E.GDITAMIHPNL..Q..NKDYEEIRPGDPLFITLGGETI
  48 -PSEREGYRFLEKVQLPENE.....A.GELTAMLHPDL..Q..DQDYQEIAPGDPFFMTLSGETI
  49 -PEQLIVHRHLKNIDFPRDS.....S.GVPSSLVHGDN..P..GRDWYPIKNGHPLFESLSGDLT
  50 -PDALVVHRHLGSRDLPKAE.....N.GEPQALVHPEL..Q..GRDWQNIASTQAMFRAADGTDR
  51 -PKNILVHRHLKSIDFPRDE.....S.GNQCGFIHSQI..Q..GKDWIPINRETPLFEDTEGNTV
  52 ----LGFYEVFERLDYPR-I.....N.EEIAAMIHPNL..Q..FKDYKPLNPGDDLFITFDGKTI
  53 -PRQVVVHRHLGSCDVPRGE.....S.DQPQALVHQRL..Q..GRDWVPFKPLDAIFEAADGSTV
  54 -PHNLVVHRHLGSVDLPRDQ.....R.DCAAAMVHPQL..Q..GQDWRPLMDGAAMFELPRGGTV
  55 ---DYDAYFYTEEVMIPVDH.....D.GMRVATVHPMI..C..GRDFGVVKPGEPLLATFFGYDI
  56 --SDYEAFFYTEEIRVPLDQ.....E.GMRQALVHPTI..C..GRDFEAVKPGAPLLATFAGYDI
  57 -PKDLVVHVHQGSVDYPRDE.....K.GDIDGLIHPKR..I..NRDWKMIKKGDPLFLNSQGIIY
  58 ---NCTVYQQIDTIDYPRDE.....Q.GQIVAEIAPHI..-..-RDYQAIKPGTPLFYHRRGNVT
  59 ---QVEAYMMEDPVDYPRDPt....T.GEITASVHSQL..Q..DKDFKLLKPGDPIFKKFSGETV
  60 --FEMDIYRNLGSVDFPRTA.....D.GDLAGTVHPQL..Q..DHDFEPLRPGEPIFKLFSGEDV
  61 ----CEAFRLGENVGFPLDE.....N.GQRTAMIHHAL..Q..DSDFKPLMPGMPVFRTFDGKDI
  62 --------------------.....-.-----------..Q..AQDSQPLLPGMPISQMFSDEDV
  63 PPCAIEVYKIIEKVDYPRDE.....N.GEIAAIIHPNL..Q..TGN-------------------
  64 PPCAIEVYKIIEKVDYPRDE.....N.GEIAAIIHPNL..Q..----------------------
  65 --FEMDIYRNLGSVDFPRTA.....D.GDLAGTVHPQL..-..----------------------


              60           70        80        90        
              |            |         |         |        
   1 PL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRSTLH
   2 PL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCSLH
   3 PL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCSLH
   4 PL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLMLNAKSIRCSV-
   5 PL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLSAKSIRSTL-
   6 PL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRSTL-
   7 PL...G..GDS...TVYPVFVNEAAYYEKKEAFAKTTKLILNARSIRSSL-
   8 PL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLSAKSIRSTL-
   9 PL...G..GDY...TVYPVFVNEAAYYEKKEAFAKTTKLTLSAKSIRSTL-
  10 PL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLSAKSIRST--
  11 PL...G..GDQ...TVYPVFVNEAAYYEKKEAFAKTTKLTLNANSIRSSL-
  12 SL...G..GDQ...TVYPVFVNEAAYYEKKEAFAKTTKLTLNANSIRSSL-
  13 PL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCCL-
  14 PL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCCL-
  15 AY...K..GDC...TAYPTFINEAAYYEKKQAFVKTIKMELTAGHIRS---
  16 PL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRSTL-
  17 PL...G..GDS...TVYPVFVNEAAYYEKKEAFAKTTKLILNARSIRSSL-
  18 AY...E..GDC...IVYPTFINEAAYYEKNQAFTTTQKMTLCAQSIRCT--
  19 LY...E..GAN...TVYPTFINEAAYYEKQQAFVTTCREILAANA------
  20 YY...Q..GPG...TVYPTFINEAAYYEKQQAFVTTRREALV---------
  21 LY...E..GDS...IVYPVFINEAAYYEKHVAFLKSEKIRVTVP-------
  22 LY...E..GDS...IVYPVFINEAAYYEKHVAFLKSEKIRVTVP-------
  23 LY...E..GES...TVYPVFINEAAYYEKGVAFVQTEKFTFTVPAM-----
  24 AY...E..GTS...TVYPIFINEAAYYEKGIAMLFTEKQLI----------
  25 LY...E..GES...TVYPVFINEAAYYEKGVAFVQTEKFTFTVPAM-----
  26 LY...E..GDS...VVYPLFVNEAAYYEKRVAFLKSEKIRISVPA------
  27 AY...E..GTS...IVYPIFINEAAYYEKGIAMLFTEKQLI----------
  28 YY...Q..EES...PVWPVFINEAAYYEKGIAMCLTKKE------------
  29 LY...N..GEK...QIYPVFINEAAYYEKKVAFIATEKTHCLVP-------
  30 RF...E..GRD...SPIPVFINEAAYVEKHIAMSLTCREVCPL--------
  31 SL...G..GDQ...TVYPVFVNEAAYYE-----------------------
  32 TY...A..DED...TIWPVFIGEVAYKEKNIAMSFTKKEVVSVS-------
  33 RF...E..EDE...PYIPVFINEAAYVEKNIAMSFTKRELWNFK-------
  34 VF...D..GED...GLVPVFINEAAYAEKAIALSLTKRETWPL--------
  35 VY...E..GAS...TVWPIFINEAAYYEKGIAMCLTQKQ------------
  36 FW...E..GDY...EAYPHFINEAAYYDNNLAMSLGKKIVV----------
  37 FW...E..GDY...EAYPHFINEAAYYDNNLAMSLGKKIVV----------
  38 SY...S..GPD...GVVPVFINEAAYAEKAIALSVTSKEEWPL--------
  39 SW...E..GDY...EAYPHFINEAAYYDNNLAMSLAKKRI-----------
  40 TC...E..EEE...PLHPFFINEGAYYEKGIAFHLAKKWILTVPSVQ----
  41 FY...E..GES...TVYPIFINEAAYYEKGIAMYLSQK-------------
  42 RY...EptDPE...PLWPVFINEAAYGEKGIALSLTRRERWPC--------
  43 KY...K..GKE...PLYPFFINECAYYEKSIALSLARKRCVVV--------
  44 LLlegG..LEE...EFVPVFINEAAYAEKNIAMSLTKKEMWDVQ-------
  45 CW...E..GDY...EAYPHFINEAAYYDNNLAMSLAKKRI-----------
  46 KY...E..EEE...PLHPLFINECAYYEKGIAFHLAKRMRLTIPAV-----
  47 PY...Q..GDK...AVYGAFINEAAYYDQHIGLSFMEKINIE---------
  48 PY...P..GTT...PVYGAFINEAAYYDAHVGLSLMEKITI----------
  49 LLlegG..LEE...EFVPVFINEAAYAEKNIAMSLTKKEMWDVQ-------
  50 CE...A..WVG...GEIPVFVNEAAYAEKSIAFSLTRREVWPVE-------
  51 KL...S..AENfqeDLIPVFINEAAYLEKGIAMSLTVRESWRF--------
  52 TY...Q..GDS...TVYPVFVNEAAYYEKGIAMCLAKQRE-----------
  53 ETp..Q..MEH...QSIPVFINEAAYAEKHIAFSLTRREVWTME-------
  54 PL...Qa.DEG...ETWPLFINEAAYAEKRIAFSLTRREVWPID-------
  55 FW...E..GKQ...EIYPHFINESAYSKANIAMALAEKKCV----------
  56 HW...N..GKG...EIYPHFINESAYSTANIAMALAKKR------------
  57 KY...D..GDQ...FIWPVFIGEVAYKEKQIAMSYTNKEVIC---------
  58 PY...Q..GAA...TVYPVFIGEAAYVEKGIAMALTQRK------------
  59 TY...E..GE-...ELYSFFINECAYYEKKIAFLLGEKV------------
  60 LY...E..GDS...IVYPVFINEA---------------------------
  61 TW...N..SDK...ETYPHFINEAAYFKLDVAFATAQRI------------
  62 LS...E..GES...TVYPVFINEAAYYENGMAVIQIEKLPL----------
  63 --...-..---...-------------------------------------
  64 --...-..---...-------------------------------------
  65 --...-..---...-------------------------------------