a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0289
- gi|55729784|emb|CAH91620.1|_203:312 hypothetical protein [Pongo pygmaeus]
- gi|55731304|emb|CAH92366.1|_203:312 hypothetical protein [Pongo pygmaeus]
- gi|4557335|ref|NP_000040.1|_203:312 aspartoacylase [Homo sapiens]
- gi|20810518|gb|AAH29128.1| Aspartoacylase [Homo sapiens]
- gi|49456771|emb|CAG46706.1| ASPA [Homo sapiens]
- gi|455834|gb|AAB29190.1| aspartoacylase; ASP [Homo sapiens]
- gi|1168340|sp|P45381|ACY2_HUMAN Aspartoacylase (Aminoacylase-2) (ACY-2) [Taxonomy]
- gi|60834485|gb|AAX37096.1|_203:312 aspartoacylase [synthetic construct]
- gi|52782193|dbj|BAD51943.1|_203:312 aspartoacylase [Macaca fascicularis]
- gi|62510428|sp|Q60HH2|ACY2_MACFA Aspartoacylase (Aminoacylase-2) (ACY-2) [Taxonomy]
- gi|56206682|emb|CAI24567.1|_202:311 aspartoacylase (aminoacylase) 2 [Mus musculus]
- gi|12833153|dbj|BAB22412.1| unnamed protein product [Mus musculus]
- gi|31560279|ref|NP_075602.2| aspartoacylase (aminoacylase) 2 [Mus musculus]
- gi|73967285|ref|XP_854515.1|_203:312 PREDICTED: similar to Aspartoacylase (Aminoacylase-2) (ACY-2) isoform 1 [Canis familiaris]
- gi|19354304|gb|AAH24934.1|_202:311 Aspartoacylase (aminoacylase) 2 [Mus musculus]
- gi|34395504|sp|Q8R3P0|ACY2_MOUSE Aspartoacylase (Aminoacylase-2) (ACY-2) [Taxonomy]
- gi|12842492|dbj|BAB25624.1|_202:311 unnamed protein product [Mus musculus]
- gi|50926810|gb|AAH78814.1|_202:311 Aspa protein [Rattus norvegicus]
- gi|50925483|gb|AAH78813.1| Aspa protein [Rattus norvegicus]
- gi|8570166|gb|AAF76459.1|_202:310 aspartoacylase ASPA [Mus musculus]
- gi|1168339|sp|P46446|ACY2_BOVIN_203:312 Aspartoacylase (Aminoacylase-2) (ACY-2) [Taxonomy]
- gi|76664250|ref|XP_586387.2|_203:312 PREDICTED: similar to Aspartoacylase (Aminoacylase-2) (ACY-2) [Bos taurus]
- gi|73967287|ref|XP_868535.1|_203:314 PREDICTED: similar to Aspartoacylase (Aminoacylase-2) (ACY-2) isoform 2 [Canis familiaris]
- gi|13242314|ref|NP_077375.1|_202:313 aspartoacylase [Rattus norvegicus]
- gi|34395488|sp|Q9R1T5|ACY2_RAT Aspartoacylase (Aminoacylase-2) (ACY-2) [Taxonomy]
- gi|5689082|dbj|BAA82801.1| aspartoacylase [Rattus norvegicus]
- gi|50758298|ref|XP_415853.1|_403:509 PREDICTED: similar to Aspartoacylase (Aminoacylase-2) (ACY-2) [Gallus gallus]
- gi|55636525|ref|XP_508599.1|_178:283 PREDICTED: similar to aspartoacylase (aminocyclase) 3; HCV core-binding protein; aspartoacylase-3 [Pan troglodytes]
- gi|14250495|gb|AAH08689.1|_202:307 Aspartoacylase (aminocyclase) 3 [Homo sapiens]
- gi|18087825|ref|NP_542389.1| aspartoacylase (aminocyclase) 3 [Homo sapiens]
- gi|21654856|gb|AAK94770.1| aspartoacylase-3 [Homo sapiens]
- gi|27373030|gb|AAN87896.1| acylase III [Homo sapiens]
- gi|34395507|sp|Q96HD9|ACY3_HUMAN Aspartoacylase-2 (Aminoacylase-3) (ACY-3) (Acylase III) (Hepatitis C virus core-binding protein 1) (HCBP1) [Taxonomy]
- gi|68361632|ref|XP_685336.1|_205:309 PREDICTED: similar to Aspartoacylase (Aminoacylase-2) (ACY-2), partial [Danio rerio]
- gi|89268929|emb|CAJ82275.1|_202:310 aspartoacylase (aminoacylase 2, Canavan disease) [Xenopus tropicalis]
- gi|47227041|emb|CAG00403.1|_364:465 unnamed protein product [Tetraodon nigroviridis]
- gi|21309896|gb|AAM46090.1|_201:305 hepatitis C virus core-binding protein 1 [Mus musculus]
- gi|12832094|dbj|BAB21963.1| unnamed protein product [Mus musculus]
- gi|27373032|gb|AAN87897.1| acylase III [Mus musculus]
- gi|14789807|gb|AAH10795.1|_201:305 Aspartoacylase-3 [Mus musculus]
- gi|31982632|ref|NP_082133.2| aspartoacylase-3 [Mus musculus]
- gi|21654858|gb|AAK94771.1| aspartoacylase-3 [Mus musculus]
- gi|19880023|gb|AAM00225.1| aspartoacylase-3 [Mus musculus]
- gi|19880021|gb|AAM00224.1| aspartoacylase-3 [Mus musculus]
- gi|74150866|dbj|BAE25538.1| unnamed protein product [Mus musculus]
- gi|34395505|sp|Q91XE4|ACY3_MOUSE Aspartoacylase-2 (Aminoacylase-3) (ACY-3) (Acylase III) (Hepatitis C virus core-binding protein 1) (HCBP1) [Taxonomy]
- gi|56789470|gb|AAH88190.1|_202:307 Aspartoacylase-3 [Rattus norvegicus]
- gi|57526957|ref|NP_001009603.1| aspartoacylase-3 [Rattus norvegicus]
- gi|17133046|dbj|BAB75611.1|_188:290 aspartoacylase [Nostoc sp. PCC 7120]
- gi|17231404|ref|NP_487952.1| aspartoacylase [Nostoc sp. PCC 7120]
- gi|34395523|sp|Q8YQC1|ASPA_ANASP Probable aspartoacylase [Taxonomy]
- gi|75701731|gb|ABA21407.1|_188:290 Succinylglutamate desuccinylase/aspartoacylase [Anabaena variabilis ATCC 29413]
- gi|75908006|ref|YP_322302.1| aspartoacylase [Anabaena variabilis ATCC 29413]
- gi|60551902|gb|AAH91576.1|_201:304 MGC97491 protein [Xenopus tropicalis]
- gi|71896001|ref|NP_001025627.1| MGC97491 protein [Xenopus tropicalis]
- gi|86438101|gb|AAI12800.1|_203:290 MGC137381 protein [Bos taurus]
- gi|23127342|ref|ZP_00109215.1|_190:290 COG2988: Succinylglutamate desuccinylase [Nostoc punctiforme PCC 73102]
- gi|71676004|ref|ZP_00673747.1|_190:289 Aspartoacylase [Trichodesmium erythraeum IMS101]
- gi|71670865|gb|EAO27532.1| Aspartoacylase [Trichodesmium erythraeum IMS101]
- gi|33635387|emb|CAE21712.1|_187:290 putative aspartoacylase [Prochlorococcus marinus str. MIT 9313]
- gi|33863804|ref|NP_895364.1| aspartoacylase [Prochlorococcus marinus str. MIT 9313]
- gi|46576457|sp|Q7V5L6|ASPA_PROMM Probable aspartoacylase [Taxonomy]
- gi|47212543|emb|CAF94992.1|_195:299 unnamed protein product [Tetraodon nigroviridis]
- gi|49901272|gb|AAH75914.1|_203:310 Zgc:92178 [Danio rerio]
- gi|50539762|ref|NP_001002347.1| hypothetical protein LOC436619 [Danio rerio]
- gi|33633723|emb|CAE18681.1|_184:286 putative aspartoacylase [Prochlorococcus marinus subsp. pastoris str. CCMP1986]
- gi|33860781|ref|NP_892342.1| aspartoacylase [Prochlorococcus marinus subsp. pastoris str. CCMP1986]
- gi|34395518|sp|P59830|ASPA_PROMP Probable aspartoacylase [Taxonomy]
- gi|87125344|ref|ZP_01081190.1|_209:312 putative aspartoacylase [Synechococcus sp. RS9917]
- gi|86167113|gb|EAQ68374.1| putative aspartoacylase [Synechococcus sp. RS9917]
- gi|49901251|gb|AAH75994.1|_214:321 Hypothetical protein LOC436874 [Danio rerio]
- gi|50540268|ref|NP_001002601.1| hypothetical protein LOC436874 [Danio rerio]
- gi|90578042|ref|ZP_01233853.1|_190:292 aspartoacylase [Vibrio angustum S14]
- gi|90441128|gb|EAS66308.1| aspartoacylase [Vibrio angustum S14]
- gi|89076336|ref|ZP_01162673.1|_190:292 aspartoacylase [Photobacterium sp. SKA34]
- gi|89047968|gb|EAR53558.1| aspartoacylase [Photobacterium sp. SKA34]
- gi|88807290|ref|ZP_01122802.1|_192:294 aspartoacylase [Synechococcus sp. WH 7805]
- gi|88788504|gb|EAR19659.1| aspartoacylase [Synechococcus sp. WH 7805]
- gi|34395519|sp|P72208|ASPA_PROMA_187:294 Probable aspartoacylase [Taxonomy]
- gi|33237228|gb|AAP99297.1| Succinylglutamate desuccinylase [Prochlorococcus marinus subsp. marinus str. CCMP1375]
- gi|33239703|ref|NP_874645.1| aspartoacylase [Prochlorococcus marinus subsp. marinus str. CCMP1375]
- gi|23124740|ref|ZP_00106710.1|_224:329 COG2988: Succinylglutamate desuccinylase [Nostoc punctiforme PCC 73102]
- gi|54302460|ref|YP_132453.1|_190:291 aspartoacylase [Photobacterium profundum SS9]
- gi|46915882|emb|CAG22653.1| hypothetical protein [Photobacterium profundum SS9]
- gi|72003277|gb|AAZ59079.1|_188:291 aspartoacylase [Prochlorococcus marinus str. NATL2A]
- gi|72383427|ref|YP_292782.1| aspartoacylase [Prochlorococcus marinus str. NATL2A]
- gi|90412575|ref|ZP_01220577.1|_190:291 aspartoacylase [Photobacterium profundum 3TCK]
- gi|90326383|gb|EAS42795.1| aspartoacylase [Photobacterium profundum 3TCK]
- gi|89093719|ref|ZP_01166666.1|_192:293 aspartoacylase [Oceanospirillum sp. MED92]
- gi|89082115|gb|EAR61340.1| aspartoacylase [Oceanospirillum sp. MED92]
- gi|88797200|ref|ZP_01112790.1|_190:292 aspartoacylase [Reinekea sp. MED297]
- gi|88780069|gb|EAR11254.1| aspartoacylase [Reinekea sp. MED297]
- gi|1542937|emb|CAB02200.1|_187:294 aspartoacylase [Prochlorococcus marinus]
- gi|87301313|ref|ZP_01084154.1|_188:292 aspartoacylase [Synechococcus sp. WH 5701]
- gi|87284281|gb|EAQ76234.1| aspartoacylase [Synechococcus sp. WH 5701]
- gi|76804021|gb|ABA55964.1|_209:310 putative aspartoacylase [Vibrio sp. DAT722]
- gi|78169679|gb|ABB26776.1|_186:291 Aspartoacylase [Synechococcus sp. CC9902]
- gi|78185385|ref|YP_377820.1| aspartoacylase [Synechococcus sp. CC9902]
- gi|78196526|gb|ABB34291.1|_186:290 Aspartoacylase [Synechococcus sp. CC9605]
- gi|78212067|ref|YP_380846.1| aspartoacylase [Synechococcus sp. CC9605]
- gi|84518709|ref|ZP_01006058.1|_216:321 aspartoacylase [Prochlorococcus marinus str. MIT 9211]
- gi|84513458|gb|EAQ09796.1| aspartoacylase [Prochlorococcus marinus str. MIT 9211]
- gi|91225714|ref|ZP_01260743.1|_186:285 aspartoacylase [Vibrio alginolyticus 12G01]
- gi|91189603|gb|EAS75878.1| aspartoacylase [Vibrio alginolyticus 12G01]
- gi|67920810|ref|ZP_00514329.1|_187:287 Aspartoacylase [Crocosphaera watsonii WH 8501]
- gi|67856927|gb|EAM52167.1| Aspartoacylase [Crocosphaera watsonii WH 8501]
- gi|78712109|gb|ABB49286.1|_189:290 Aspartoacylase [Prochlorococcus marinus str. MIT 9312]
- gi|78778610|ref|YP_396722.1| Aspartoacylase [Prochlorococcus marinus str. MIT 9312]
- gi|16329830|ref|NP_440558.1|_187:284 aspartoacylase [Synechocystis sp. PCC 6803]
- gi|1652315|dbj|BAA17238.1| aspartoacylase, ASP [Synechocystis sp. PCC 6803]
- gi|34395520|sp|P73211|ASPA_SYNY3 Probable aspartoacylase [Taxonomy]
- gi|47219983|emb|CAG11516.1|_57:155 unnamed protein product [Tetraodon nigroviridis]
- gi|33866454|ref|NP_898013.1|_187:291 aspartoacylase [Synechococcus sp. WH 8102]
- gi|33633232|emb|CAE08437.1| putative aspartoacylase [Synechococcus sp. WH 8102]
- gi|34395517|sp|P59829|ASPA_SYNPX Probable aspartoacylase [Taxonomy]
- gi|88796549|ref|ZP_01112214.1|_187:288 aspartoacylase [Alteromonas macleodii 'Deep ecotype']
- gi|88772108|gb|EAR03408.1| aspartoacylase [Alteromonas macleodii 'Deep ecotype']
- gi|94398243|ref|XP_001001236.1|_7:74 PREDICTED: similar to aspartoacylase-3 [Mus musculus]
- gi|73983588|ref|XP_854611.1|_449:534 PREDICTED: similar to Aldehyde dehydrogenase 3B1 (Aldehyde dehydrogenase 7) [Canis familiaris]
- gi|55644795|ref|XP_511268.1|_203:248 PREDICTED: similar to ASPA protein [Pan troglodytes]
- gi|31418016|gb|AAH10941.1|_203:251 ASPA protein [Homo sapiens]
- gi|20384689|gb|AAK51135.1|_202:248 hepatitis C virus core-binding protein 1 [Homo sapiens]
- gi|19880078|gb|AAM00248.1| HCBP1 [Homo sapiens]
- gi|21654941|gb|AAK94773.1|_4:41 aspartoacylase-3 [Mus spretus]

              10           20        30             40          50     
              |            |         |              |           |     
   1 ALDFIQRFNEGKEF..PPCA.IDVYKIMEKVDYPRNE.....SGDVAAVIHPNLQ..DQDWKPLH
   2 -LDFIHHFNEGKEF..PPCA.IEVYKIIEKVDYPRDE.....NGEIAAVIHPNLQ..DQDWKPLH
   3 -LDFIHHFNEGKEF..PPCA.IEVYKIIEKVDYPRDE.....NGEIAAVVHPNLQ..DQDWKPLH
   4 -LDFIHHFNEGKEF..PPCA.IEVYKIIEKVDYPRDE.....NGEIAAIIHPNLQ..DQDWKPLH
   5 -LDFIHHFNEGKEF..PPCA.IEVYKIIEKVDYPRDE.....NGEIAAIIHPNLQ..DQDWKPLH
   6 -LDFIHHFNEGKEF..PPCA.IEVYKIIEKVDYPRDE.....NGEIAAVIHPNLQ..DQDWKPLH
   7 -LDFIQHFNEGKEF..PPCS.IDVYKIMEKVDYPRNE.....SGDMAAVIHPNLQ..DQDWKPLH
   8 -LDFIHNFNEGKEF..PPCA.IEVYKIMEKVDYPRNE.....NGDIAALIHPNLQ..DQDWKPLH
   9 -LDFIQHFNEGKEF..PPCS.IDVYKIMEKVDYPRNE.....SGDMAAVIHPNLQ..DQDWKPLH
  10 -LDFIQHFNEGKEF..PPCS.IDVYKIMEKVDYPRNE.....SGDMAAVIHPNLQ..DQDWKPLH
  11 -LDFIQRFNEGKEF..PPCA.IDVYKIMEKVDYPRNE.....SGDVAAVIHPNLQ..DQDWKPLH
  12 -LDFIQHFNEGKEF..PPCS.IDVYKIMEKVDYPRNE.....SGDMAAVIHPNLQ..DQDWKPLH
  13 -LDFIHNFNEGKEF..PPCA.IEVYKIMRKVDYPRNE.....SGEISAIIHPKLQ..DQDWKPLH
  14 -LDFIHNFNEGKEF..PPCA.IEVYKIMEKVDYPRNE.....SGEISAIIHPKLQ..DQDWKPLH
  15 -LDFIHNFNEGKEF..PPCA.IEVYKIMEKVDYPRNE.....NGDIAALIHPNLQlsDQDWKPLH
  16 -LDFIQRFNEGKEF..PPCA.IDVYKIMEKVDYPRNE.....SGDVAAVIHPNLQlqDQDWKPLH
  17 -LDFVHLFNEGKEF..PPCT.IEVYKITEKVDYPRNK.....NDEVIAIIHPNLQ..DQDWQPLN
  18 VLDFIELFNQGTAF..PAFE.MEAYRPVGVVDFPRTE.....AGNLAGTVHPQLQ..DRDFQPLQ
  19 VLDFIELFNQGTAF..PAFE.MEAYRPVGVVDFPRTE.....AGHLAGTVHPQLQ..DRDFQPLQ
  20 -LDFIELFNNGVEF..PPCT.VNVFRVQERMDYPRDT.....NGNITAMVHPHLQ..DCDWEPLN
  21 -LDFINYFNDGKEF..LPCI.LEVFKVLDNVAYPRNA.....NGDCTAIIHNNLQ..DQDWNELK
  22 -LDFIELFNEGVEF..PACT.VEVFRVLERVDYPRDT.....NGNIIAMVHPNLQ..DCDWEPLT
  23 ILDFIELFNQGMDL..PAFE.MDIYRNLGSVDFPRTA.....DGDLAGTVHPQLQ..DHDFEPLR
  24 ILDFIELFNQGMDL..PAFE.MDIYRNLGSVDFPRTA.....DGDLAGTVHPQLQ..DHDFEPLR
  25 ILDFIELFNQGMEF..PAFE.MEVYKNLGSVDFPRTT.....DGHLTGTVHSRLQ..DHDFEPLR
  26 ILDYLEQYNRGNIP..KINNlLALYKFTGTVDYPRNE.....NGDIQGMIHPDIQ..FRDYEPLN
  27 ILDYVEKYNQGNIPk.INNL.LSLYKFTGTIDYPRNG.....NGDIQAMIHPDIQ..FRDYAPLN
  28 -LDFLDLFNQGTEF..PSFE.TDVHQVLYRADFPRNE.....DGEIEAVIHSELQ..DKDYLPLK
  29 -LDFIHNFNEGKEF..PPCA.IEVYKIMEKVDYPRNE.....SGEISAIIHPKLQ..DQDWKPLH
  30 VLDYLEQFNQGKIAs.TNET.LILYDHLSVVDYPKQQ.....DGKIFAMIHPELQ..DKDYQALN
  31 -LDFIEHFNEGKLDh.INRD.IVIYKHLKVVDYPKTK.....DGEIVAMIHPQLQ..GRDYQKLS
  32 CLEALSSVASGSPT..YPDE.FVVHSHLGSLDLPRDA.....LGQPAACVHPSLQ..GRDWQPLQ
  33 VLDWVRSFNSGTIF..EGGC.VDVFTMVKHIDYPRERd....TGNIIAAVHPQLQ..DRDFCLLH
  34 -IDWIHKFNSGTVF..EGGD.VEAFKIIKSVDYPRDPv....TRSLNAAVHPQLQ..DRDFCLLK
  35 --DEINKLKNNQIR..LPKD.LFVHVHQGSIDYPRDK.....NGNINALIHPERI..NQDWKPIK
  36 -LHLIAAAWNGRML..TPER.LVVHRHLGSLDLPRDP.....QGRADALIHPELQ..GRDWSPIR
  37 -IDWIHKFNSGTVF..EGGD.VEAFKFIKSVDYPRDPe....TRNLTAAVHPQLQ..DRDFCLLK
  38 ILDFVHLNNTNEVPe.LPAS.YDAYCYEETLKLPEDE.....QGERIGMVHQSVQ..DNDFEPLR
  39 ILDFVHLNNTNEVPe.LPAS.YDAYCYEETLKLPVDE.....QGERIGMVHQSVQ..DNDFEPLR
  40 -LAAITSVRDGSAR..YPDQ.VVIHLHLGSLDVPRRS.....SGDPDALVHPNLQ..GRDWQPLK
  41 CLKEISNVINSKTV..YPEQ.LIVHRHLKNIDFPRDS.....SGVPSSLVHKDIQ..GRDWYPIK
  42 ILDYFEGCNQGNIPh.TSSQ.LTFYQYIETIDYPRSDay6lqSGEIQAMIHPQLQ..FKDYEPLN
  43 ILDYVDLHNTNALPe.LPSS.YEAFEYKETLKLPENE.....NGERIGMVHKNVQ..DGDFKQLN
  44 -MEQIHEVKNLNLF..FPNK.LIIHRHIKSIDFPRDE.....EGNIDGYVHSLRQ..SKDWQELK
  45 ILDYVDLHNTNALPe.LSSS.YEAFEYTETLKLPENE.....NGERIGMVHKNVQ..DGDFKQLN
  46 -LDYLELKNTGQTPd.LPMQ.MGGYRFTKKIRLPENE.....EGDITAMIHPNLQ..NKDYEEIR
  47 CLDFLELWNQKAVPe.LPSE.REGYRFLEKVQLPENE.....AGELTAMLHPDLQ..DQDYQEIA
  48 CLKEISNVINSKTV..YPEQ.LIVHRHLKNIDFPRDS.....SGVPSSLVHGDNP..GRDWYPIK
  49 -LAVLASARRGDLA..LPRG.LTVHRHLGSLDLPRHP.....DGRPAACLHPLRQ..HRDWQVIR
  50 VLDYLEQHNLGQVG..ELND.YDAYFYTEEVMIPVDH.....DGMRVATVHPMIC..GRDFGVVK
  51 CFEALASVRSGVVR..LPRQ.VVVHRHLGSCDVPRGE.....SDQPQALVHQRLQ..GRDWVPFK
  52 CLRALYQVRQELAR..LPDA.LVVHRHLGSRDLPKAE.....NGEPQALVHPELQ..GRDWQNIA
  53 -IDEIALAKSGKAK..FPKN.ILVHRHLKSIDFPRDE.....SGNQCGFIHSQIQ..GKDWIPIN
  54 VLDYVEKHNLNQIG..LLSD.YEAFFYTEEIRVPLDQ.....EGMRQALVHPTIC..GRDFEAVK
  55 -LDYLDKKNQDQIPe.KSHK.LGFYEVFERLDYPR-I.....NEEIAAMIHPNLQ..FKDYKPLN
  56 --DEIDKLKKNLIE..LPKD.LVVHVHQGSVDYPRDE.....KGDIDGLIHPKRI..NRDWKMIK
  57 ILAYLQASTSGNVP..AADN.CTVYQQIDTIDYPRDE.....QGQIVAEIAPHI-..-RDYQAIK
  58 -FEFVQEFNAGHTF..EGGQ.VEAYMMEDPVDYPRDPt....TGEITASVHSQLQ..DKDFKLLK
  59 -CQELAAARAGTGR..DPHN.LVVHRHLGSVDLPRDQ.....RDCAAAMVHPQLQ..GQDWRPLM
  60 ILDFCMAYNNGSIStdNLPQ.CEAFRLGENVGFPLDE.....NGQRTAMIHHALQ..DSDFKPLM
  61 --------------..---E.MDIYRNLGSVDFPRTA.....DGDLAGTVHPQLQ..DHDFEPLR
  62 -LDFIELFNQAV--..----.-------------RAE.....VGPSNPGLRLSSQ..AQDSQPLL
  63 -LDFIHHFNEGKEF..PPCA.IEVYKIIEKVDYPRDE.....NGEIAAIIHPNLQ..--------
  64 -LDFIHHFNEGKEF..PPCA.IEVYKIIEKVDYPRDE.....NGEIAAIIHPNLQ..TGN-----
  65 VLDFIELFNQGTAF..PAFE.MEAYRPVGVVDFPRTE.....AGHLAGTVHPQAC..--------
  66 --------NQGMDL..PAFE.MDIYRNLGSVDFPRTA.....DGDLAGTVHPQL-..--------


         60        70                80        90       100       110  
         |         |                 |         |         |         |  
   1 PGDPVFVSLDGKVIPL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRSTLH
   2 PGDPMFLTLDGKTIPL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCSL-
   3 PGDPMFLTLDGKTIPL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCSL-
   4 PGDPMFLTLDGKTIPL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCCL-
   5 PGDPMFLTLDGKTIPL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCCL-
   6 PGDPMFLTLDGKTMPL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLMLNAKSIRCSV-
   7 PGDPVFVSLDGKVIPL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLSAKSIRSTL-
   8 PGDPVFLTLEGKSIPL...G..GDS...TVYPVFVNEAAYYEKKEAFAKTTKLILNARSIRSSL-
   9 PGDPVFVSLDGKVIPL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLSAKSIRSTL-
  10 PGDPVFVSLDGKVIPL...G..GDY...TVYPVFVNEAAYYEKKEAFAKTTKLTLSAKSIRSTL-
  11 PGDPVFVSLDGKVIPL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRSTL-
  12 PGDPVFVSLDGKVIPL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLSAKSIRST--
  13 PEDPVFLTLDGKTIPL...G..GDQ...TVYPVFVNEAAYYEKKEAFAKTTKLTLNANSIRSSL-
  14 PEDPVFLTLDGKTISL...G..GDQ...TVYPVFVNEAAYYEKKEAFAKTTKLTLNANSIRSSL-
  15 PGDPVFLTLEGKSIPL...G..GDS...TVYPVFVNEAAYYEKKEAFAKTTKLILNARSIRSSL-
  16 PGDPVFVSLDGKVIPL...G..GDC...TVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRSTL-
  17 NGDPLFLTLDGEVIAY...K..GDC...TAYPTFINEAAYYEKKQAFVKTIKMELTAGHIR----
  18 PGAPIFQMFSGEDLLY...E..GES...TVYPVFINEAAYYEKGVAFVQTEKFTFTVPA------
  19 PGAPIFQMFSGEDLLY...E..GES...TVYPVFINEAAYYEKGVAFVQTEKFTFTVPA------
  20 RGDPMFLTFDGRTILY...E..GAN...TVYPTFINEAAYYEKQQAFVTTCREILAANA------
  21 PGDPMFLTLDGRMIAY...E..GDC...IVYPTFINEAAYYEKNQAFTTTQKMTLCAQSIRCT--
  22 PGDPMFQTFDGKTIYY...Q..GPG...TVYPTFINEAAYYEKQQAFVTTRREALV---------
  23 PGEPIFKLFSGEDVLY...E..GDS...IVYPVFINEAAYYEKHVAFLKSEKIRVTVP-------
  24 PGEPIFKLFSGEDVLY...E..GDS...IVYPVFINEAAYYEKHVAFLKSEKIRVTVP-------
  25 PGEPIFKLFSGEDVLY...E..GDS...VVYPLFVNEAAYYEKRVAFLKSEKIRISVPA------
  26 PGDPLFLTLDGKAIAY...E..GTS...TVYPIFINEAAYYEKGIAMLFTEKQLI----------
  27 PGDPLFLTLDGKAIAY...E..GTS...IVYPIFINEAAYYEKGIAMLFTEKQLI----------
  28 PGDPIFQRLNGEDILY...N..GEK...QIYPVFINEAAYYEKKVAFIATEKTHCLVP-------
  29 PEDPVFLTLDGKTISL...G..GDQ...TVYPVFVNEAAYYE-----------------------
  30 PGDPMFITFDNKTIVY...E..GAS...TVWPIFINEAAYYEKGIAMCLTQKQ------------
  31 PGEPMFLTFDNQTIYY...Q..EES...PVWPVFINEAAYYEKGIAMCLTKKE------------
  32 MGAPLFLWPDGEVFRF...E..GRD...SPIPVFINEAAYVEKHIAMSLTCREVCPL--------
  33 PEDPLFQTFSGETLKY...K..GKE...PLYPFFINECAYYEKSIALSLARKRCVVV--------
  34 RGDPLFLSFSGETVKY...E..EEE...PLHPLFINECAYYEKGIAFHLAKRMRLTIPAVQ----
  35 KDAPLFMDMEGKTKTY...A..DED...TIWPVFIGEVAYKEKNIAMSFTKKEVVSVS-------
  36 RGDPLFLTAAGDTISY...S..GPD...GVVPVFINEAAYAEKAIALSVTSKEEWPLS-------
  37 RGDPLFLSFSGETVTC...E..EEE...PLHPFFINEGAYYEKGIAFHLAKKWILTVPSVQ----
  38 SGDPIFTLFDGTEIFW...E..GDY...EAYPHFINEAAYYDNNLAMSLGKKIVV----------
  39 SGDPIFTLFDGTEIFW...E..GDY...EAYPHFINEAAYYDNNLAMSLGKKIVV----------
  40 AGDPLFIDAESNTVVF...D..GED...GLVPVFINEAAYAEKAIALSLTKRETWPL--------
  41 NGHPLFESLSGDLTLLlegG..LEE...EFVPVFINEAAYAEKNIAMSLTKKEMWDVQ-------
  42 PGDPMFLTFAGKDIFY...E..GES...TVYPIFINEAAYYEKGIAMYLSQK-------------
  43 SGDPIFTLFDGSEISW...E..GDY...EAYPHFINEAAYYDNNLAMSLAKKRI-----------
  44 KNDELFCKLNGEIIRF...E..EDE...PYIPVFINEAAYVEKNIAMSFTKRELWNFK-------
  45 SGDPIFTLFDGSEICW...E..GDY...EAYPHFINEAAYYDNNLAMSLAKKRI-----------
  46 PGDPLFITLGGETIPY...Q..GDK...AVYGAFINEAAYYDQHIGLSFMEKINI----------
  47 PGDPFFMTLSGETIPY...P..GTT...PVYGAFINEAAYYDAHVGLSLMEKITI----------
  48 NGHPLFESLSGDLTLLlegG..LEE...EFVPVFINEAAYAEKNIAMSLTKKEMWDVQ-------
  49 PGDPLFVTAGGETLRY...EptDPE...PLWPVFINEAAYGEKGIALSLTRRERWPC--------
  50 PGEPLLATFFGYDIFW...E..GKQ...EIYPHFINESAYSKANIAMALAEKKCV----------
  51 PLDAIFEAADGSTVETp..Q..MEH...QSIPVFINEAAYAEKHIAFSLTRREVWTME-------
  52 STQAMFRAADGTDRCE...A..WVG...GEIPVFVNEAAYAEKSIAFSLTRREVWPVE-------
  53 RETPLFEDTEGNTVKL...S..AENfqeDLIPVFINEAAYLEKGIAMSLTVRESWRF--------
  54 PGAPLLATFAGYDIHW...N..GKG...EIYPHFINESAYSTANIAMALAKKR------------
  55 PGDDLFITFDGKTITY...Q..GDS...TVYPVFVNEAAYYEKGIAMCLAKQREI----------
  56 KGDPLFLNSQGIIYKY...D..GDQ...FIWPVFIGEVAYKEKQIAMSYTNKEVICS--------
  57 PGTPLFYHRRGNVTPY...Q..GAA...TVYPVFIGEAAYVEKGIAMALTQRK------------
  58 PGDPIFKKFSGETVTY...E..GE-...ELYSFFINECAYYEKKIAFLLGEKV------------
  59 DGAAMFELPRGGTVPL...Qa.DEG...ETWPLFINEAAYAEKRIAFSLTRREVWPID-------
  60 PGMPVFRTFDGKDITW...N..SDK...ETYPHFINEAAYFKLDVAFATAQRI------------
  61 PGEPIFKLFSGEDVLY...E..GDS...IVYPVFINEA---------------------------
  62 PGMPISQMFSDEDVLS...E..GES...TVYPVFINEAAYYENGMAVIQIEKLPLCACP------
  63 ----------------...-..---...-------------------------------------
  64 ----------------...-..---...-------------------------------------
  65 ----------------...-..---...-------------------------------------
  66 ----------------...-..---...-------------------------------------