a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0279 1wcw, Thermus thermophilus
- gi|41410102|ref|NP_962938.1|_275:531 CysG [Mycobacterium avium subsp. paratuberculosis str. k10]
- gi|41398935|gb|AAS06554.1| CysG [Mycobacterium avium subsp. paratuberculosis str. k10]
- gi|15607652|ref|NP_215025.1|_288:544 cysG [Mycobacterium tuberculosis H37Rv]
- gi|31791693|ref|NP_854186.1| PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM) [Mycobacterium bovis AF2122/97]
- gi|7477955|pir||B70652 probable cysG protein - Mycobacterium tuberculosis (strain H37RV) [Taxonomy]
- gi|31617279|emb|CAD93386.1| PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM) [Mycobacterium bovis AF2122/97]
- gi|38490198|emb|CAE55293.1| PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM) [Mycobacterium tuberculosis H37Rv]
- gi|15839904|ref|NP_334941.1|_291:547 uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Mycobacterium tuberculosis CDC1551]
- gi|13880041|gb|AAK44755.1| uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Mycobacterium tuberculosis CDC1551]
- gi|25027006|ref|NP_737060.1|_392:650 putative uroporphyrin-III C-methyltransferase CysG [Corynebacterium efficiens YS-314]
- gi|23492286|dbj|BAC17260.1| putative uroporphyrin-III C-methyltransferase CysG [Corynebacterium efficiens YS-314]
- gi|21323194|dbj|BAB97822.1|_309:567 Uroporphyrinogen-III synthase [Corynebacterium glutamicum ATCC 13032]
- gi|19551674|ref|NP_599676.1|_317:575 uroporphyrinogen-III synthase/methylase [Corynebacterium glutamicum ATCC 13032]
- gi|41324663|emb|CAF19145.1| UROPORPHYRINOGEN III SYNTHASE/METHYLTRANSFERASE [Corynebacterium glutamicum ATCC 13032]
- gi|38233016|ref|NP_938783.1|_270:529 Putative uroporphyrin-III C-methyltransferase [Corynebacterium diphtheriae NCTC 13129]
- gi|38199275|emb|CAE48906.1| Putative uroporphyrin-III C-methyltransferase [Corynebacterium diphtheriae]
- gi|23507699|gb|AAN38292.1|_309:567 uroporphobilinogen-III synthase [Corynebacterium glutamicum]
- gi|29831284|ref|NP_825918.1|_283:539 putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Streptomyces avermitilis MA-4680]
- gi|29608399|dbj|BAC72453.1| putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Streptomyces avermitilis MA-4680]
- gi|15828302|ref|NP_302565.1|_286:543 possible uroporphyrin-III C-methyltransferase [Mycobacterium leprae TN]
- gi|25400474|pir||H87211 probable uroporphyrin-III C-methyltransferase [imported] - Mycobacterium leprae [Taxonomy]
- gi|13093995|emb|CAC31936.1| possible uroporphyrin-III C-methyltransferase [Mycobacterium leprae]
- gi|23473894|ref|ZP_00129189.1|_244:498 COG1587: Uroporphyrinogen-III synthase [Desulfovibrio desulfuricans G20]
- gi|21221748|ref|NP_627527.1|_276:532 putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Streptomyces coelicolor A3(2)]
- gi|7481703|pir||T36265 probable uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase - Streptomyces coelicolor [Taxonomy]
- gi|5123662|emb|CAB45351.1| putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Streptomyces coelicolor A3(2)]
- gi|48836011|ref|ZP_00293008.1|_273:530 COG0007: Uroporphyrinogen-III methylase [Thermobifida fusca]
- gi|46579147|ref|YP_009955.1|_244:498 uroporphyrinogen III synthase/methyltransferase [Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough]
- gi|46448560|gb|AAS95214.1| uroporphyrinogen III synthase/methyltransferase [Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough]
- gi|46364598|ref|ZP_00227195.1|_321:575 COG1587: Uroporphyrinogen-III synthase [Kineococcus radiotolerans SRS30216]
- gi|49235877|ref|ZP_00329941.1|_250:503 COG0007: Uroporphyrinogen-III methylase [Moorella thermoacetica ATCC 39073]
- gi|48845542|ref|ZP_00299820.1|_252:508 COG0007: Uroporphyrinogen-III methylase [Geobacter metallireducens GS-15]
- gi|50876623|emb|CAG36463.1|_255:515 probable uroporphyrinogen III synthase/methyltransferase (HemD+CobA) [Desulfotalea psychrophila LSv54]
- gi|16331265|ref|NP_441993.1|_272:533 uroporphyrin-III synthase [Synechocystis sp. PCC 6803]
- gi|7469420|pir||S76085 hypothetical protein - Synechocystis sp. (strain PCC 6803) [Taxonomy]
- gi|1001439|dbj|BAA10063.1| uroporphyrin-III synthase [Synechocystis sp. PCC 6803]
- gi|23114410|ref|ZP_00099713.1|_250:502 COG0007: Uroporphyrinogen-III methylase [Desulfitobacterium hafniense]
- gi|23113472|ref|ZP_00098844.1|_216:468 COG1587: Uroporphyrinogen-III synthase [Desulfitobacterium hafniense]
- gi|23125855|ref|ZP_00107772.1|_267:522 COG0007: Uroporphyrinogen-III methylase [Nostoc punctiforme]
- gi|19421891|gb|AAL87779.1|_195:447 putative uroporphyrinogen III synthase/methyltransferase [Desulfitobacterium hafniense]
- gi|50841809|ref|YP_055036.1|_285:541 uroporphyrinogen-III synthase, HemD [Propionibacterium acnes KPA171202]
- gi|50839411|gb|AAT82078.1| uroporphyrinogen-III synthase, HemD [Propionibacterium acnes KPA171202]
- gi|27117224|emb|CAD48147.1|_5:253 uroporphyrinogen III synthase [Bacillus megaterium]
- gi|16078288|ref|NP_389105.1|_5:266 yjjA [Bacillus subtilis subsp. subtilis str. 168]
- gi|7474613|pir||D69851 conserved hypothetical protein yjjA - Bacillus subtilis [Taxonomy]
- gi|2612895|gb|AAC46319.1| unknown [Bacillus subtilis]
- gi|2633577|emb|CAB13080.1| yjjA [Bacillus subtilis subsp. subtilis str. 168]
- gi|48837760|ref|ZP_00294720.1|_28:278 COG1587: Uroporphyrinogen-III synthase [Methanosarcina barkeri str. fusaro]
- gi|33866742|ref|NP_898301.1|_4:257 putative uroporphyrinogen III synthase [Synechococcus sp. WH 8102]
- gi|33639343|emb|CAE08725.1| putative uroporphyrinogen III synthase [Synechococcus sp. WH 8102]
- gi|29831663|ref|NP_826297.1|_13:278 putative transcriptional regulator [Streptomyces avermitilis MA-4680]
- gi|29608779|dbj|BAC72832.1| putative transcriptional regulator [Streptomyces avermitilis MA-4680]
- gi|21226410|ref|NP_632332.1|_17:267 Uroporphyrinogen-III synthase [Methanosarcina mazei Go1]
- gi|20904668|gb|AAM30004.1| Uroporphyrinogen-III synthase [Methanosarcina mazei Goe1]
- gi|47076743|dbj|BAD18288.1|_2:262 unknown conserved protein [Geobacillus stearothermophilus]
- gi|47076789|dbj|BAD18331.1|_2:261 unknown conserved protein [Geobacillus kaustophilus]
- gi|33864231|ref|NP_895791.1|_8:267 putative uroporphyrinogen III synthase [Prochlorococcus marinus str. MIT 9313]
- gi|33635815|emb|CAE22140.1| putative uroporphyrinogen III synthase [Prochlorococcus marinus str. MIT 9313]
- gi|46198620|ref|YP_004287.1|_2:251 uroporphyrinogen-III synthase [Thermus thermophilus HB27]
- gi|46196243|gb|AAS80660.1| uroporphyrinogen-III synthase [Thermus thermophilus HB27]
- gi|21221403|ref|NP_627182.1|_23:286 putative transcriptional regulator [Streptomyces coelicolor A3(2)]
- gi|6911988|emb|CAB72204.1| putative transcriptional regulator [Streptomyces coelicolor A3(2)]
- gi|12655814|gb|AAK00606.1|_254:504 uroporphyrinogen III synthase/methyltransferase [Selenomonas ruminantium subsp. ruminantium]
- gi|2495181|sp|Q59335|HEM4_CHLVI_3:244 Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) [Taxonomy]
- gi|144480|gb|AAA23114.1| uroporphyrinogenIII cosynthase [Taxonomy]
- gi|47092001|ref|ZP_00229795.1|_243:485 uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Listeria monocytogenes str. 4b H7858]
- gi|47019717|gb|EAL10456.1| uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Listeria monocytogenes str. 4b H7858]
- gi|46907420|ref|YP_013809.1|_243:485 uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Listeria monocytogenes str. 4b F2365]
- gi|46880688|gb|AAT03986.1| uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Listeria monocytogenes str. 4b F2365]
- gi|15614725|ref|NP_243028.1|_5:268 BH2162~unknown conserved protein [Bacillus halodurans C-125]
- gi|25490293|pir||B83920 hypothetical protein BH2162 [imported] - Bacillus halodurans (strain C-125) [Taxonomy]
- gi|10174781|dbj|BAB05881.1| BH2162 [Bacillus halodurans C-125]
- gi|21674249|ref|NP_662314.1|_3:242 uroporphyrinogen-III synthase [Chlorobium tepidum TLS]
- gi|25453020|sp|Q8KCJ3|HEM4_CHLTE Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) [Taxonomy]
- gi|21647417|gb|AAM72656.1| uroporphyrinogen-III synthase [Chlorobium tepidum TLS]
- gi|20091852|ref|NP_617927.1|_20:275 uroporphyrinogen-III synthase [Methanosarcina acetivorans str. C2A]
- gi|19917043|gb|AAM06407.1| uroporphyrinogen-III synthase [Methanosarcina acetivorans str. C2A]
- gi|16803241|ref|NP_464726.1|_243:485 similar uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase [Listeria monocytogenes EGD-e]
- gi|47095043|ref|ZP_00232656.1| uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Listeria monocytogenes str. 1/2a F6854]
- gi|25315416|pir||AI1224 uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase homolog lmo1201 [imported] - Listeria monocytogenes (strain EGD-e) [Taxonomy]
- gi|16410617|emb|CAC99279.1| lmo1201 [Listeria monocytogenes]
- gi|47016661|gb|EAL07581.1| uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Listeria monocytogenes str. 1/2a F6854]
- gi|16079866|ref|NP_390692.1|_4:255 uroporphyrinogen III cosynthase [Bacillus subtilis subsp. subtilis str. 168]
- gi|399875|sp|P21248|HEM4_BACSU Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) [Taxonomy]
- gi|482987|pir||B42728 uroporphyrinogen-III synthase (EC 4.2.1.75) hemD - Bacillus subtilis [Taxonomy]
- gi|143038|gb|AAA22513.1| uroporphyrinogen III synthase [Taxonomy]
- gi|2635279|emb|CAB14774.1| uroporphyrinogen III cosynthase [Bacillus subtilis subsp. subtilis str. 168]
- gi|46366045|ref|ZP_00228452.1|_23:287 COG1587: Uroporphyrinogen-III synthase [Kineococcus radiotolerans SRS30216]
- gi|15607401|ref|NP_214774.1|_7:275 hypothetical protein Rv0260c [Mycobacterium tuberculosis H37Rv]
- gi|15839642|ref|NP_334679.1| transcriptional regulator, putative [Mycobacterium tuberculosis CDC1551]
- gi|31791438|ref|NP_853931.1| POSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN [Mycobacterium bovis AF2122/97]
- gi|7476268|pir||G70626 hypothetical protein Rv0260c - Mycobacterium tuberculosis (strain H37RV) [Taxonomy]
- gi|1850105|emb|CAB06687.1| POSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN [Mycobacterium tuberculosis H37Rv]
- gi|13879761|gb|AAK44493.1| transcriptional regulator, putative [Mycobacterium tuberculosis CDC1551]
- gi|31617023|emb|CAD93130.1| POSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN [Mycobacterium bovis AF2122/97]
- gi|2500949|sp|Q59294|HEM4_CLOJO_247:498 Porphyrin biosynthesis protein HEMD [Includes: Uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM); Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing])] [Taxonomy]
- gi|2127342|pir||I40811 uroporphyrinogen-III synthase (EC 4.2.1.75) - Clostridium josui [Taxonomy]
- gi|460693|dbj|BAA05862.1| uroporphyrinogen-III synthase [Clostridium josui]
- gi|41409804|ref|NP_962640.1|_5:274 hypothetical protein MAP3706c [Mycobacterium avium subsp. paratuberculosis str. k10]
- gi|41398636|gb|AAS06256.1| hypothetical protein MAP3706c [Mycobacterium avium subsp. paratuberculosis str. k10]
- gi|15678194|ref|NP_275309.1|_3:252 uroporphyrinogen III synthase [Methanothermobacter thermautotrophicus]
- gi|3122179|sp|O26268|HEM4_METTH Putative uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) [Taxonomy]
- gi|7482444|pir||H69088 hypothetical protein MTH166 - Methanobacterium thermoautotrophicum (strain Delta H) [Taxonomy]
- gi|2621208|gb|AAB84672.1| uroporphyrinogen III synthase [Methanothermobacter thermautotrophicus str. Delta H]
- gi|23099113|ref|NP_692579.1|_7:264 uroporphyrinogen-III synthase [Oceanobacillus iheyensis HTE831]
- gi|22777341|dbj|BAC13614.1| uroporphyrinogen-III synthase [Oceanobacillus iheyensis HTE831]
- gi|48833625|ref|ZP_00290643.1|_5:254 COG1587: Uroporphyrinogen-III synthase [Magnetococcus sp. MC-1]
- gi|23010960|ref|ZP_00051474.1|_19:280 COG1587: Uroporphyrinogen-III synthase [Magnetospirillum magnetotacticum]
- gi|18401160|ref|NP_565625.1|_67:308 uroporphyrinogen-III synthase family protein [Arabidopsis thaliana]
- gi|20196944|gb|AAC14502.2| expressed protein [Arabidopsis thaliana]
- gi|18694346|emb|CAC85287.1|_67:308 uroporphyrinogen III synthase [Arabidopsis thaliana]
- gi|49483912|ref|YP_041136.1|_20:218 uroporphyrinogen III synthase [Staphylococcus aureus subsp. aureus MRSA252]
- gi|49242041|emb|CAG40740.1| uroporphyrinogen III synthase [Staphylococcus aureus subsp. aureus MRSA252]
- gi|21283342|ref|NP_646430.1|_20:218 uroporphyrinogen III synthase [Staphylococcus aureus subsp. aureus MW2]
- gi|49486496|ref|YP_043717.1| uroporphyrinogen III synthase [Staphylococcus aureus subsp. aureus MSSA476]
- gi|2589182|gb|AAC45834.1| uroporphyrinogen III synthase [Staphylococcus aureus]
- gi|21204782|dbj|BAB95478.1| uroporphyrinogen III synthase [Staphylococcus aureus subsp. aureus MW2]
- gi|49244939|emb|CAG43400.1| uroporphyrinogen III synthase [Staphylococcus aureus subsp. aureus MSSA476]
- gi|15924659|ref|NP_372193.1|_20:218 uroporphyrinogen III synthase [Staphylococcus aureus subsp. aureus Mu50]
- gi|15927248|ref|NP_374781.1| uroporphyrinogen III synthase [Staphylococcus aureus subsp. aureus N315]
- gi|25506550|pir||C89950 uroporphyrinogen III synthase [imported] - Staphylococcus aureus (strain N315) [Taxonomy]
- gi|13701466|dbj|BAB42760.1| uroporphyrinogen III synthase [Staphylococcus aureus subsp. aureus N315]
- gi|14247441|dbj|BAB57831.1| uroporphyrinogen III synthase [Staphylococcus aureus subsp. aureus Mu50]
- gi|15669184|ref|NP_247989.1|_2:234 uroporphyrinogen III synthase (hemD) [Methanocaldococcus jannaschii DSM 2661]
- gi|3122192|sp|Q58401|HEM4_METJA Putative uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) [Taxonomy]
- gi|2129350|pir||B64424 uroporphyrinogen-III synthase (EC 4.2.1.75) - Methanococcus jannaschii [Taxonomy]
- gi|1591657|gb|AAB98999.1| uroporphyrinogen III synthase (hemD) [Methanocaldococcus jannaschii DSM 2661]
- gi|27381067|ref|NP_772596.1|_5:270 blr5956 [Bradyrhizobium japonicum USDA 110]
- gi|27354233|dbj|BAC51221.1| blr5956 [Bradyrhizobium japonicum USDA 110]
- gi|50796733|ref|XP_423886.1|_14:260 PREDICTED: similar to Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) (UROIIIS) [Gallus gallus]
- gi|29655355|ref|NP_821047.1|_1:262 uroporphyrinogen-III synthase [Coxiella burnetii RSA 493]
- gi|29542627|gb|AAO91561.1| uroporphyrinogen-III synthase [Coxiella burnetii RSA 493]
- gi|39933333|ref|NP_945609.1|_4:242 putative UROPORPHYRINOGEN-III synthase [Rhodopseudomonas palustris CGA009]
- gi|39652958|emb|CAE25700.1| putative UROPORPHYRINOGEN-III synthase [Rhodopseudomonas palustris CGA009]
- gi|15606833|ref|NP_214213.1|_9:243 putative protein [Aquifex aeolicus VF5]
- gi|7517485|pir||E70452 hypothetical protein aq_1771 - Aquifex aeolicus [Taxonomy]
- gi|2984071|gb|AAC07611.1| putative protein [Aquifex aeolicus VF5]
- gi|21592861|gb|AAM64811.1|_67:308 uroporphyrinogen III synthase [Arabidopsis thaliana]
- gi|15807683|ref|NP_285335.1|_274:512 uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Deinococcus radiodurans R1]
- gi|7474090|pir||G75593 uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase - Deinococcus radiodurans (strain R1) [Taxonomy]
- gi|6460581|gb|AAF12287.1| uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Deinococcus radiodurans]
- gi|27375677|ref|NP_767206.1|_3:244 bll0566 [Bradyrhizobium japonicum USDA 110]
- gi|27348815|dbj|BAC45831.1| bll0566 [Bradyrhizobium japonicum USDA 110]
- gi|50083561|ref|YP_045071.1|_6:244 uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) [Acinetobacter sp. ADP1]
- gi|49529537|emb|CAG67249.1| uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) [Acinetobacter sp. ADP1]
- gi|39937093|ref|NP_949369.1|_5:270 Uroporphyrinogen III synthase HEM4 [Rhodopseudomonas palustris CGA009]
- gi|39650951|emb|CAE29474.1| Uroporphyrinogen III synthase HEM4 [Rhodopseudomonas palustris CGA009]
- gi|32475041|ref|NP_868035.1|_8:265 uroporphyrinogen III synthase, uroporhyrinogen decarboxylase [Pirellula sp. 1]
- gi|32445581|emb|CAD75582.1| uroporphyrinogen III synthase, uroporhyrinogen decarboxylase [Pirellula sp.]
- gi|15805812|ref|NP_294510.1|_6:249 uroporphyrinogen-III synthase, putative [Deinococcus radiodurans R1]
- gi|7473731|pir||F75476 probable uroporphyrinogen-III synthase - Deinococcus radiodurans (strain R1) [Taxonomy]
- gi|6458497|gb|AAF10363.1| uroporphyrinogen-III synthase, putative [Deinococcus radiodurans]
- gi|45190953|ref|NP_985207.1|_18:255 AER351Wp [Eremothecium gossypii]
- gi|44984021|gb|AAS53031.1| AER351Wp [Eremothecium gossypii]
- gi|18313455|ref|NP_560122.1|_12:271 uroporphyrinogen-III synthase (hemD), conjectural [Pyrobaculum aerophilum str. IM2]
- gi|18160991|gb|AAL64304.1| uroporphyrinogen-III synthase (hemD), conjectural [Pyrobaculum aerophilum str. IM2]
- gi|15889909|ref|NP_355590.1|_2:240 AGR_C_4810p [Agrobacterium tumefaciens str. C58]
- gi|17936528|ref|NP_533318.1| conserved hypothetical protein [Agrobacterium tumefaciens str. C58]
- gi|25520738|pir||F97677 hypothetical protein AGR_C_4810 [imported] - Agrobacterium tumefaciens (strain C58, Cereon) [Taxonomy]
- gi|25522733|pir||AD2902 conserved hypothetical protein Atu2653 [imported] - Agrobacterium tumefaciens (strain C58, Dupont) [Taxonomy]
- gi|15157860|gb|AAK88375.1| AGR_C_4810p [Agrobacterium tumefaciens str. C58]
- gi|17741156|gb|AAL43634.1| conserved hypothetical protein [Agrobacterium tumefaciens str. C58]
- gi|45916929|ref|ZP_00195983.2|_3:229 COG1587: Uroporphyrinogen-III synthase [Mesorhizobium sp. BNC1]
- gi|34495507|ref|NP_899722.1|_3:239 uroporphyrinogen-III synthase [Chromobacterium violaceum ATCC 12472]
- gi|34101363|gb|AAQ57732.1| uroporphyrinogen-III synthase [Chromobacterium violaceum ATCC 12472]
- gi|13473576|ref|NP_105144.1|_3:233 hypothetical protein, contains weak similarity to uroporphyrinogen III synthase [Mesorhizobium loti MAFF303099]
- gi|14024326|dbj|BAB50930.1| hypothetical protein [Mesorhizobium loti]
- gi|46199445|ref|YP_005112.1|_10:222 putative uroporphyrinogen-III synthase hemD [Thermus thermophilus HB27]
- gi|46197071|gb|AAS81485.1| putative uroporphyrinogen-III synthase hemD [Thermus thermophilus HB27]
- gi|16081676|ref|NP_394047.1|_22:222 hypothetical protein [Thermoplasma acidophilum DSM 1728]
- gi|10639741|emb|CAC11713.1| hypothetical protein [Thermoplasma acidophilum]
- gi|47214888|emb|CAG01019.1|_14:240 unnamed protein product [Tetraodon nigroviridis]
- gi|15791134|ref|NP_280958.1|_16:200 uroporphyrin-III C-methyltransferase; CysG [Halobacterium sp. NRC-1]
- gi|25410644|pir||B84384 uroporphyrin-III C-methyltransferase [imported] - Halobacterium sp. NRC-1 [Taxonomy]
- gi|10581744|gb|AAG20438.1| uroporphyrin-III C-methyltransferase; CysG [Halobacterium sp. NRC-1]
- gi|46119163|ref|ZP_00176154.2|_241:389 COG0007: Uroporphyrinogen-III methylase [Crocosphaera watsonii WH 8501]
- gi|15966833|ref|NP_387186.1|_2:231 PUTATIVE UROPORPHYRINOGEN-III SYNTHASE PROTEIN [Sinorhizobium meliloti 1021]
- gi|15076105|emb|CAC47659.1| PUTATIVE UROPORPHYRINOGEN-III SYNTHASE PROTEIN [Sinorhizobium meliloti]
- gi|22045244|gb|AAL38830.2|_9:180 unknown protein [Arabidopsis thaliana]
- gi|18313454|ref|NP_560121.1|_2:221 uroporphyrinogen-III synthase (hemD), conjectural [Pyrobaculum aerophilum str. IM2]
- gi|18160990|gb|AAL64303.1| uroporphyrinogen-III synthase (hemD), conjectural [Pyrobaculum aerophilum str. IM2]
- gi|46192521|ref|ZP_00207318.1|_40:232 hypothetical protein Rsph022467 [Rhodobacter sphaeroides]

              10             20        30        40         50         
              |              |         |         |          |         
   1 MRRLEEDAVRVAYAGL.....RRKEAFKALAEKLGFTPLLFPVQATEKVPVP.EYRDQVR..A..
   2 WESRALYGWTVLVPRTk....DQAGEMSERLTSYGALPIEVPTIAVEPPRSP.AQMERAVkgL..
   3 WESRALYGWTVLVPRTk....DQAGEMSERLTSYGALPVEVPTIAVEPPRSP.AQMERAVkgL..
   4 WESRALYGWTVLVPRTk....DQAGEMSERLTSYGALPVEVPTIAVEPPRSP.AQMERAVkgL..
   5 WENRALYGWRVLVPRAk....PQAAAMSARLASHGAIPQEVPTISVEPPRNP.AQMERAIkgI..
   6 WENRALYGWRVLVPRAr....EQAASMSARLSSHGAIPQEVPTISVEPPRNP.AQMERAIkgI..
   7 WENRALYGWRVLVPRAr....EQAASMSARLSSHGAIPQEVPTISVEPPRNP.AQMERAIkgI..
   8 WESRALFGWRVLVPRAk....DQAGPMSSRIAAYGAIAQEVPTISVEPPRNP.AQLERAIkgI..
   9 WENRALYGWRVLVPRAr....EQAASMSARLSSHGAIPQEVPTISVEPPRNP.AQMERAIkgI..
  10 FESKPLFGWKVLVPRTk....EQAASLSDQLRSYGAVPHEVPTIAVEPPRTP.QQMERAVkgL..
  11 WESRALYGWTVLVPRTk....DQAGEMSERLTSYGALPVEVPTIAVEPPRSP.AQMERAVkgL..
  12 FEQLPLLGRGIVVTRAr....EQASGLAASLTQLGAEVIQFPTILIRPLEDY.APVHDAI..R..
  13 FESKPLFGWKVLVPRTk....EQAASLSDQLRSYGAVPSEVPTIAVEPPRTP.QQMERAVkgL..
  14 FETKPLFGWRVLVPRTr....QQAPALSEQLRSYGAVPEEVPTISVEPPRTP.QQMERAVrgL..
  15 FEHKPLLGKGVVVTRAr....EQASGLAAALRELGADVIQFPTIDIHPLDDY.APVHEAI..R..
  16 -ETKPLFGWRVLVPRTk....EQAGGVTAKLSDHGATAEVVPTISVEPPRTP.QQMEKAVkgL..
  17 -EDKPLFGRRVIVTRPr....AQAEGLTRSLADLGAEVINFPVIRTEPPADW.HPLDTAL..D..
  18 FDNRPLFGTSILVTRAa....DQAGEFGAMLGALGARVLECPTIAIVPPESW.DNLDAAI..A..
  19 FEKRPLFGKKIIVTRTr....EQASELVQELEEQGANCLECATIKISPIKEP.KELDNAL..E..
  20 --PLPLTEKTILVTRAa....DQASQFTELLHQQGATVLAMAALEIVPPKDW.QPLDQAI..A..
  21 FEKKPLFGSRIVVTRAr....HQAGVLAQAIEDLGGEPWEFPAIEIREPSDP.ELLTRAM..Q..
  22 FEKRPLFGQRIIVTRAr....HQASALSQGIEDLGGEPWEFPAIEIVPPRDP.QPLIQAI..K..
  23 ---EPLTGKTILVTRSv....GQSSTFSDRLTTLGATVIEMPTLEIGPPSSW.EALDDAI..A..
  24 FEKKPLFGSRIVVTRAr....HQAGVLAQAIEDLGGEPWEFPAIEIREPSDP.ELLTRAM..Q..
  25 -ESKPLFGWNILIPRTr....DHSATLPSRLQSYGAHSLDVPTISMEPPRTP.QQMDKAIrgL..
  26 ---APLFLKKVLITREa....KQAHSFAAQIKKLGGIPLSLPVLTFARSNNE.KEVEDVL..L..
  27 -----LLGKRVAIGGS.....RKTEEISTIIEKQGGIPVIRPLQGTVYLAEK.QVEPDLRt.F..
  28 ------------IMRPe....SYREKSEALAQDYGFEPLYVPMIRLEGIKDE.GFEPFIRr.V..
  29 ----PLQNCTVVVTRAa....DQLGEARRLLETQGAQVLDLPALVIGPPDDW.GPLDDAL..S..
  30 --HGPLAGFTVGVTAA.....RRADELGALLQRRGASVVHAPALRIVPLADD.SELLAATkgL..
  31 ------------IMRPe....SYREKSEAIARDYGFEPLCVPMIKLEGIKDD.GFEPFIQr.V..
  32 ------HGKRIALCAS.....RKLDEMTTLIEKQGGTAIIRPAQGTVFSKGS.ELGEEMRt.V..
  33 ------HGKRIALCAS.....RKLDEMTTLIEKQGGTAIIRPAQGTVFSKGS.ELGEEMRt.V..
  34 ----PLHGRTIIMTRAq....EQQSEARSQLHALGSNVLDLPALVIGPPDDW.QPLDDAL..A..
  35 ---------RIAYAGL.....RRKEEFKALAEKLGFTPLLFPVQATEKVPVP.EYRDQVR..E..
  36 ---GPLAGFTVGVTAA.....RRADELGALLGRRGATVLHAPALRIVPLADD.GELMAATkrI..
  37 --QRPLFGKRILVTRAr....SQASKLTAKLEKLGAEVLEAPAISMADPADNyAALDKAI..D..
  38 ---------TVLVTRPk....HQAAPFVRELEQYGLSTVVFPTIEIRPVAGW.NVPD---..-..
  39 FEEMPLFHTKVLLPRAr....AGKSMLAEQIRDLGGEVTMYPNIQVVDVVPT.KTKEE--..-..
  40 FEEMPLFHTKVLLPRAr....AGKSMLAEQIRDLGGEVTMYPNIQVVDVVPT.KTKEE--..-..
  41 -----LSGYKVVLAGT.....RKTDEMSTLIEKQGGTPLVRSLQGTVFRVDD.EVLKDLEt.F..
  42 ---------TVLVTRPk....HQAEPFVRELAQYGLDSVVFPTIEIRPVTGW.SVPD---..-..
  43 ------------IMRPe....SYREKSEAIARDYGFEPVYVPMIQLEGLKDE.VFEPFVQr.V..
  44 FEEMPLFHTKVLLPRAr....AGKSMLAEQIRDLGGEVTMYPNIQVLDVAPT.KTKEQ--..-..
  45 --DFPLKGKTVLVTRNk....AQAASFQQKVEALGGKAVLTSLITFRRALPN.DVAEQVR..E..
  46 ---PQLLGVTVGVTSD.....RRSGDMVATFERKGARVVHAPTMRIVPLTED.DQLLAETrdV..
  47 ---APLTGYRIAVTSA.....RRAEELCALLRRQGAEVCSAPAIKMIALPDD.DELQNNTeaL..
  48 -MKKPLFGTKILVTRPk....ESSGTLVEKLRQLGAEPVEYPCIEVVPIPQN.EKLYHAC..E..
  49 -DSAPLTGYRIAVTSA.....NRAEELCALLRRNGAEVTSAAAINIIALPED.QELHRHTeaV..
  50 ------------VTRPp....ERSAEAVELIEGAGGRALVAPTLELKEAHTE.SL-REVC..R..
  51 --------KRIGIAAS.....RRSDEIAALVKKIGGTPIVFSIQGEQILNNE.TSEHDVFe.L..
  52 ----ALHQRTILVTRPq....PEADATALLILQAGGTPIITPMLNIAPAEDS.QPLQQAI..A..
  53 -------GCTVLVTAD.....RRKSELAAALQRRGAEVRHAPALSMIPHADD.EQLLAGTrdL..
  54 ----------VVVTREr....GKNNQIIKALEKNGISSLELPLIQHARGPDF.DRLASV-..L..
  55 ----------VVVTREr....GKNNQIIKALEKNGISSLELPLIQHARGPDF.DRLASV-..L..
  56 ----------------.....----------------IIHKPFIDIKPLNFD.-----IH..L..
  57 ----------------.....----------------IIHKPFIDIKPLNFD.-----IH..L..
  58 ----------------.....----------------IIHKPFIDIKPLNFD.-----IH..L..
  59 ---------KVVITRPk....ERADVFASLLKKEGFEPIIFPTLEIVYNKDL.D------..V..
  60 -----LNGYRILILET.....REEAQFSKLLAEQGADVVQCPMFTIHDAPDP.APVEAWIrrA..
  61 ----------------.....SGPDPYVKELGLYGFEATLIPVLSFEFVSLE.GLFEKL-..S..
  62 MENESLKNKTIMITRPe....WQGELLKKAIERRGGAVILFPTLIIKPINKC.NYSPFAS..As1
  63 -----------LVTRPq....PDGDATAKALRAKGYDVLLAPMLRFEPVPFP.DDPDA--..-..
  64 ---MKLSYKRVILTREl....EDIKKDKPLFEREGFKVLELPLIQTKVLEFN.-------..L..
  65 ----------VVVTREr....GKNNQIIKALEKNGISSLELPLIQHARGPDF.DRLASV-..L..
  66 ---LPLQGAQVAVTRTre...QTGSELAALLSGRGAQVSEIPLLRFVPASSP.RTLVG--..A..
  67 ----------ILVTRPh....PDNEATADNLRARGHVVLLAPVLKFEPVAFH.DESEA--..-..
  68 -------------TRPa....DRADELTQAVSAQGYRVENLPLLVLKKKPFS.AHLKQLY..Q..
  69 -----LQGTRILILET.....REEAQFARLLTEQGADVLQCPMFEIRDAPDP.APVSAWIdrL..
  70 -----FDGLRVAALES.....RRADDMTRLICKFGGEAFVSPSMREVPIEPN.RAAIDFAyrI..
  71 --SLPLQGHTVAVTRPdsggdGGGGRLGELLRAQGAEVLSVPLIRFLPPADP.RALWSGL..R..
  72 ----------------.....---DHYETIFESNGFQTHFVPIITHEHLPDE.VRGRLSDa.N..
  73 --------WTVIITSGrp...SKAELLAKLIIKAGGEPVYLPTVKVEESGSD.--ISTVI..G..
  74 ---------RIVVTRPq....RSGERTAAKLEALGHAPVLLPLFHPIHHGER.----ATS..A..
  75 ---------RVLVTRPe....PGASRTAGRLAALGFEPVLLPLTKIVPLPVE.-----TW..S..
  76 ---------RVLAARPl....AQCAGLLEKLRAEGWQAGHLPLMEIEPLPEA.--LAALP..A..
  77 ---------RVLVTRPe....PGASRTALRLQETGFQPVVLPLTETVALPAD.-----AG..F..
  78 ----------------.....----ALLARLAALGIEAAEVALLEQVDLPAR.ALLSE--..K..
  79 ----------------.....--------------FDILNVPVTRLEPIPVD.----YTD..L..
  80 ----------------.....SGIDPYIEELAAHGHTAALVPVLAFAFVSSN.T-LSDKM..F..
  81 ----------------.....-------------------------------.-------..-..
  82 ---LPLAQKTILITRAk....EQSSQFSLLLQQQGAKTIEMPALEILPPSSW.DQLDLAI..E..
  83 ---------RVLVTRPr....PAAERTAARLSAMGHEAVILPLMQAQHLAGA.-----ARa.A..
  84 ----------------.....-------------------------------.-------..-..
  85 ---------RVVVTSP.....FAGEAFTRVLK--GVEVAVAPVLKLMPVKVE.--GEAVA..S..
  86 ----------------.....-------------------------------.-------..A..


            60        70              80             90       100      
            |         |               |              |         |      
   1 ...LAQGVDLFLATTGVGVRDLL.....E.AGKALGL.....DLEGPLAKAFRLARGAKAARALK
   2 ...VDGRFQWVVFTSTNAVRAVW.....E.KFGEFGL.....D-ARAFSGVKIACVGESTADRVR
   3 ...VDGRFQWIVFTSTNAVRAVW.....E.KFGEFGL.....D-ARAFSGVKIACVGESTADRVR
   4 ...VDGRFQWIVFTSTNAVRAVW.....E.KFGEFGL.....D-ARAFSGVKIACVGESTADRVR
   5 ...VEGRYQWVVLTSVNAVRAVW.....D.MITEFGL.....D-SRSFAGVRIAAVGEKTAAEIR
   6 ...VEGRYQWVVLTSVNAVKAVW.....E.KITEFGL.....D-SRSFAGVRIAAVGEKTAAEIR
   7 ...VEGRYQWVVLTSVNAVKAVW.....E.KITEFGL.....D-SRSFAGVRIAAVGEKTAAEIR
   8 ...VEGRYQWVVFTSVNAVKAVR.....E.KIVSFGL.....D-SRAFAGVHIAAVGAKTAAAIR
   9 ...VEGRYQWVVLTSVNAVKAVW.....E.KITEFGL.....D-SRSFAGVRIAAVGEKTAAEIR
  10 ...VTGRYEWIAFTSVNAVKAVR.....E.KFEEYGL.....D-ARAFAGIKVAAVGEQTAKALV
  11 ...VDGRFQWVVFTSTNAVRAVW.....E.KFGEFGL.....D-ARAFSGVKIACVGEATADRVR
  12 ...RLAEYDWLVFTSVNGVKHFW.....Q.QMGLLGL.....D-SRALGGVKVAAIGPATADVLR
  13 ...VTGRYEWIAFTSVNAVKAVR.....E.KFEEYGL.....D-ARAFAGIKVAAVGEQTANALI
  14 ...VTGRYQWVAFTSVNAVKAIR.....E.RIEDYGL.....D-ARAFAGVKVAAVGEQTAAALR
  15 ...ALDTYDWVVFTSVNGVKHFW.....N.QLAALGL.....D-SRALGGRKVAAIGPATADALR
  16 ...VTGRYEWIGFTSVNAVRAVR.....E.KFTEYGL.....D-ARAFSGLKVAAVGGVTADALR
  17 ...AIGEFDWIIFTSANGVRYFW.....R.RLLERHQ.....D-IRSLAGIRIAAIGPATSRALK
  18 ...SLDRFHWAVFTSVNAVRFFF.....E.RLAAAGK.....D-SRALGNCRVCAVGPKTAAALA
  19 ...RLQEFHWILFTSINGVKYFF.....E.RLFSKGM.....D-ARDLKGCDIAVVGPSTADYLR
  20 ...KLGDFDWLILTSANGVEFFF.....Q.RLQHHGL.....D-SRALAGLKLAVVGKKTAQSLE
  21 ...DLRRFKWLVFTSANGVERFL.....S.GLKDSGK.....D-IRDLSGMEIVAVGPVTQAALE
  22 ...NLKRFEWLIFTSVNGVEEFF.....K.VLMEQGR.....D-VRDLAGMDVVAIGPATRDALE
  23 ...HLSQFDWLILTSSNGIDYFF.....E.RLIAQGK.....D-TRALAGVKIAVVGEKTANSLK
  24 ...DLRRFKWLVFTSANGVERFL.....S.GLKDSGK.....D-IRDLSGMEIVAVGPVTQAALE
  25 ...VEGRYEWVVFTSANAVRAVS.....E.KLEQIGL.....D-ARAYSGLRIAAIFDSTINALA
  26 ...SIDCFDWIVFTSQNGISFFF.....E.WLKELNI.....S-WSALKRLKVAAVGEKTAKLLE
  27 ...AEEKADWVIFTTGIGLETLV.....D.MAEKIGLkd...EFLQAIRQAKAACRGYKTLSALK
  28 ...LTGSSDYVVFTSANGISFTL.....D.KLSETEKk....DFITALKKIKVIAIGPNTEKELI
  29 ...ELEDFHWLVVSSANGVQAVE.....Q.RLQRLGR.....SLLRRPANLRIAAVGRKTARALE
  30 ...IEQAPDVVVATTAIGFRGWI.....E.AADGWGLge...DLIERLRGVELLARGPKVKGAVR
  31 ...IDGTSDYVVFTSANGITFTL.....D.KLTEDEKk....NFITALKKRKVIAIGPNTEKELV
  32 ...IAMRPDWIVFTTGIGFEALL.....E.AADREGMaa...QWHRTIKEANVAARGYKTVTALK
  33 ...IAMRPDWIVFTTGIGFEALL.....E.AADREGMaa...EWHRTIKEANVAARGYKTVTALK
  34 ...DIKTFHWLVFSSANGVRAVE.....E.RLQRIGQ.....SLANRPKGLKLAAVGRKTAQYLE
  35 ...LAQGVDLFLATTGVGVRDLL.....E.AGKALGL.....DLEGPLAKAFRLARGAKAARALK
  36 ...VDRAPDVVVATTAIGFRGWV.....E.AADGWGLgd...ALLERLRTVELLARGPKVKGAVR
  37 ...HVADYHWLIFTSANGVGRFF.....A.RLFKAGK.....D-ARALGYAKIAAIGLATAEKLK
  38 ...-LTKFAGIFFTSPNSVQFFL.....K.HLLQTAP.....DELKNLQQTRVWAVGKTTGQDLE
  39 ...-LREVSGLLFTSKEAVERFF.....D.YLAQLDL.....D-IRSLKNTHLTAIGKQTKEAFS
  40 ...-LSEVSELLFTSKEAVERFF.....D.YLAQLDL.....D-IRSLKNTHLTAIGKQTKEAFS
  41 ...ISKGADWAILTTGIGTNTLV.....E.LAERIGKkd...EFLARLKEANIAARGYKTKNVIK
  42 ...-LTRFAGIFFTSPNSVQFFL.....E.RLLEESP.....DELPNLQQARVWAVGKTTGGDLE
  43 ...VKGTSDYVVFTSANGITFTL.....D.KLTKPEKe....KFIAALKKTRVIAIGPNTEKELV
  44 ...-LSEVSELLFTSKEAVERFF.....D.YLAKLDL.....D-IRSLKNSHLTAIGKQTKEAFS
  45 ...DLAAPGWLVFTSVNGADFFF.....S.YLKENQL.....I---LPAHKKIAAVGEKTARRLK
  46 ...IADPPDDVLITTGIGLRGWV.....E.AADAAGLaa...PLLETFGRARLFARGPKATGVIR
  47 ...IADPPDILVAHTGIGFRGWL.....A.AAEGWGLan...ELLESLSSARIISRGPKATGALR
  48 ...NIREYGWILLTSKNGIQIFF.....D.YLNSKGL.....D-ARVLANTKIGTVGSQTAKALK
  49 ...IAQPPDILVAHTGIGFRGWV.....A.AADGWGLap...QLLSALSQARIVARGPKATGALR
  50 ...RADEWDLVIFTSQAAVESLF.....Q.LCREFAG.....K---IRKDCLVAVIGPRTARVAG
  51 ...IDNAFDFVVLTTGIGASTLE.....E.ASLRVSRfp...EFISKLSSIPLAIRGSKTEKWLK
  52 ...AIHSFDGVLITSANAARAYL.....D.ALAAQAQ.....P---LSGTPPCFAVGPKTAELLR
  53 ...VERPPDVVVVTTGIGFRSWV.....E.AADAHGLad...RLLEVLADARIVARGPKARGAIQ
  54 ...NDKSFDWIIITSPEAGSVFL.....E.AWKTASS.....P------EVQIGVVGAGTARVFE
  55 ...NDKSFDWIIITSPEAGSVFL.....E.AWKTASS.....P------EVQIGVVGAGTARVFE
  56 ...LNQRYDWLIFSSKNAVKFFY.....K.YLKGINV.....D--------NIAVIGSKTAQYCE
  57 ...LNQRYDWLIFSSKNAVKFFY.....K.YLKGINV.....D--------NIAVIGSKTAQYCE
  58 ...LNQRYDWLIFSSKNAVKFFY.....K.YLKGINV.....D--------NIAVIGSKTAQYCE
  59 ...NLDSYDWIAFTSPSGVIGLY.....N.ILTENER.....E---NVKNKKIAVIGEKTAKTFK
  60 ...IDRPFDDLVLMTGEGLRRIM.....K.LARTRGLdq...ALVAALAKSRKFTRGPKPGKALR
  61 ...HPECYGGLVFTSPRALEAIK.....I.CLRENSKne6skSLKQEWNAKPTYVVGKATASLVE
  62 9agFLNSSDILIFLSANAVKHSP.....I.-------.....--LNFKAEQKLVAIGTGTAAALF
  63 ...---HYTGVIVTSANALRALD.....D.------Q.....PVLARLLKLPLFAVGKHTARKAQ
  64 ...PDEEFDYIVFQSKKAVKIFL.....G.K------.....--VNLKGNKKIVAVGKKTAEELE
  65 ...NDKSFDWIIITSPEAGSVFL.....E.AWKTASS.....P------EVQIGVVGAGTARVFE
  66 ...LNGFDGWVLLTSEQAVRALA.....R.TLLAAGR.....D-LRVLARARIAAVGSGTAWTLR
  67 ...---NYSAIIVTSANAIRAVA.....P.QLQDLGL.....L------KLPLFAVGEHTATAAR
  68 ...QLDQSQLIVVVSPTAVEIGM.....Q.YLQKANI.....S-LSSLSHIRWVAVGKSTAKALQ
  69 ...IAAPFDDLVLLTGEGLRRLT.....K.LARATGRer...PFVAAVGRTRTFIRGPKPGRALR
  70 ...ITGDIGIVIVMTGVGFRYLL.....K.ATEKHVDqq...RLIDALSDITTICRGPKPVAVMR
  71 ...DLRGVDWLLVTSPQGGRLLG.....E.ALAAAGV.....A---DLAGTRLAAVGEATARELR
  72 ...YMKRLNCLVVTSQRTVECLY.....EdVLPSLPA.....EARKSLLNTPVFVVGRATQEFME
  73 ...HLTWSQAVLFMTGQSAWGLA.....E.LAKRAQRle...EVRTLLSQRELLCRGMKASGNVK
  74 ...LSDPAGAIAVTSAEALRALA.....T.CEEQ---.....--LAPYLSKPLFAVGGATAEAAQ
  75 ...GAENIAALAITSANAVRHTP.....P.-------.....PLLRDLAGLPAFAVGERTAQVAA
  76 ...QAARADALFWVSPSAIDVGW.....P.ALAGMDF.....S------GKRLACVGAASARRLA
  77 ...VTGDAVAVAVTSANAVRHAS.....N.-------.....EVIAALAALPCHAVGARTAEAAR
  78 ...LKEGWDYVAVTSKEGAKRLL.....L.AWEEAGR.....P------FLRVAAVGEGTAGVLR
  79 ...IRSGVDCVAFTSSYGVRLFF.....K.-------.....--NAPVKNFRYFGIGKSTCEEVR
  80 ...QPEKHGGLIFTSPRAVEAVKmc6tqQ.RLEEWNK.....CVKDKWNARSIYVVGKATASLVR
  81 ...-----AVVVVTSKTGVELAA.....D.SGWTPGG.....G--------RLAAIGPATADACR
  82 ...TLSSFDWLILTSANGVNFFF.....Q.RLKELGK.....D-IRLLGNIKIAVVGKKTASCLQ
  83 ...LSEPHQAIAVSSGEAVRVLG.....A.LGPA---.....--LEPHLATPLFAVGEATARAAG
  84 ...--------------------.....-.----ASS.....P------EVQIGVVGAGTARVFE
  85 ...AVSNSDLVVFVSGRAAYRLR.....E.EGIRLDL.....A-----GKIVATAEGRKGAVMVK
  86 ...IPLRPDALIFTSETGVEGYR.....R.LAAPELS.....D------VRRAWCVGNRTARAAE


        110                120       130            140             150
         |                  |         |              |               |
   1 .EAGLPP.H.....AVG...DGTSKSLLPLLPQGR.....GVAALQLYG.....KPLP.LLENAL
   2 .AFGISP.E.....LVPag.EQSSLGLLDDFPPYDsv6pvNRVLLPRAD.....IATE.TLAEGL
   3 .AFGISP.E.....LVPsg.EQSSLGLLDDFPPYDsv6pvNRVLLPRAD.....IATE.TLAEGL
   4 .AFGISP.E.....LVPsg.EQSSLGLLDDFPPYDsv6pvNRVLLPRAD.....IATE.TLAEGL
   5 .ALGITP.E.....LLPprnRQNAQGIVDVFPEYIee6pvGRVLLPRAD.....IATD.VLVDGL
   6 .ALGITP.E.....LLPartRQNAQGLVDVFPEYFee6pvGRVLLPRAD.....IATD.VLVDGL
   7 .ALGITP.E.....LLPartRQNAQGLVDVFPEYFee6pvGRVLLPRAD.....IATD.VLVDGL
   8 .EFGITP.E.....LIPprkEHNAAGMVSVFPNYVeg6pvGRVLLPRAD.....IATD.VLVDGL
   9 .ALGITP.E.....LLPartRQNAQGLVDVFPEYFee6pvGRVLLPRAD.....IATD.VLVDGL
  10 .AFGVKP.D.....LVPsg.EQSAAGLLEDWPPYDpv6piDRVFLPRAD.....IATE.TLVAGL
  11 .AFGISP.E.....LVPag.EQSSLGLLDEFPPYDsv6pvNRVLLPRAD.....IATE.TLAEGL
  12 .EKGIEP.D.....FIPe..KYVAEGVVKGMIERGmdg..SRVLLPRAR.....VARE.VLPEEL
  13 .AFGVKP.D.....LVPsg.EQSAAGLLEDWPPYDpv6piDRVFLPRAD.....IATE.TLVAGL
  14 .AFGIHP.D.....LQPpedKQSAAGLVEVWPPYDpd6piERVLLPRAD.....IATE.VLSEGL
  15 .DKGIAP.D.....FIPe..KYVAEGVVEGMLARGmgg..KRVLLPRAL.....EARE.VLPEEL
  16 .EWGIEP.D.....LVPeg.EQSASGLLEAWPPYDdv6piNRVFLPRAD.....IATD.TLVAGL
  17 .ERGLLT.D.....WQPr..EYVAEAVASGLGPRVrg...RRVLLPRAD.....IARP.FLAVDL
  18 .PFGIRP.D.....LIPa..DYKGEGVVEVFRSEEiag..KRIIFPKGD.....RARD.VIPQGL
  19 .KYGLNA.D.....LFPp..VFTGEGLAQALLDQGveg..RNILIPRAQ.....QARE.IVPENL
  20 .KFGLKP.D.....FIPp..DFIADALVEHFPHSPagl..KILFPRVES.....GGRA.QLVQEL
  21 .QRGLCV.T.....CMPe..EYRAEGILAELTGRIlpg..EGVLLARAE.....EARD.VLPQSL
  22 .KRCLKV.S.....FVPe..EYRAEKIIEGLASRVlpg..QSVLLARAE.....EARD.ILPESL
  23 .QYSLQP.D.....FIPp..NFVADSLIENFPEKLdgk..KVLFPRVES.....GGRE.ILVKEL
  24 .QRGLCV.T.....CMPe..EYRAEGILAELTGRIlpg..EGVLLARAE.....EARD.VLPQSL
  25 .EWGVRP.D.....FVPsg.EQSTRALAAVFPAFDea6piNRVFVPRAD.....IATE.SLSADL
  26 .KHDVNV.Q.....LVPk..EYVAESLLESLKANVshh..ERVLLVRGQ.....LARS.VLKDGL
  27 .KLGITP.E.....ASDe..DGTTRGLIRSLEPHDfsg..KTVMVQLHG.....EKAP.ALMAFL
  28 .KIGIDN.S.....FLPg..DYSSKGIVEALCPEVag...KTVDLARSA.....FGAK.VLIEGL
  29 .DLGATA.D.....FVPp..SFVADSLIDHFPVSGygl..RMLLPRVQS.....GGRT.VLAEAF
  30 .AAGLTE.E.....WSPss.ESMAEVLDRLLEEGVdg...RRVAIQLHG.....EPLP.GFVEAL
  31 .RIGIEN.S.....FMPa..DYSSEGIVEALCPEVkg...KTVDLARSA.....YGAK.LLIDGL
  32 .QIGVTP.V.....AASe..DGTTKGLIAALYGHDfae..KNVVVQLYG.....DTAP.ALKQFF
  33 .QIGVTP.V.....AASe..DGTTKGLIVALDGHDfad..KNVVVQLYG.....DTAP.ALRQFF
  34 .HLGAAV.D.....FVPp..NFVADSLINHFPVSGfgl..KMLLPRVQS.....GGRT.ILGEAF
  35 .EAGLPP.H.....AVG...DGTSKSLLPLLPQGR.....GVAALQLYG.....KPLP.LLENAL
  36 .AAGLTE.R.....WSPas.ESMAEVLDRLLEQGVag...RRIAVQLHG.....EPLP.GFVEAL
  37 .QYGLVA.D.....VIPq..EYRAEGVLEALKGKLpph..AKILIPRAE.....EARE.VLPDTL
  38 .KHGVSI.E.....PLPk..IADAVNLMADIDPAEikg..QTFLFVRGS.....LSLG.TIPELI
  39 .EKGIIP.D.....SFIk..RRSTELILEHLPRLQk....NVSNLIIGS.....IVDT.AEVNAI
  40 .EKGIIP.D.....SFIk..RRSTELILEHLPRLQk....NVSNLIIGS.....IVDT.AEVNAI
  41 .QLGLQA.E.....VVDn..DGTVSGLVAAMEGADvtg..KRVMVQLHG.....ENAP.KLLAFL
  42 .KHGVSI.E.....PLPk..SADAVSLMSGIDASEieg..KTFLFVRGS.....LSLG.TIPEVI
  43 .KIGIEK.P.....FLPg..DYSSEGIVEALCPEVkg...KTIDLARSA.....FGAK.VLIEGL
  44 .EKGIIP.D.....SFIk..RRSTELILEHLPRLQk....NVSNLIIGS.....VVDT.TEVNVI
  45 .MHNVSV.D.....VMPq..EYIAEQLADALKQHAepg..ETITVMKGN.....LSRD.VIKQEL
  46 .ANGLRE.E.....WSAas.EQTAEAVQRLVTEGVag...RSIVVQLHG.....AADQ.DQLEPL
  47 .AAGLRE.E.....WSPds.ESSHEVLEYLLESGVsr...TRIAVQLHGaadswDPFP.EFLGGL
  48 .EVGLIS.D.....FTPe..IFDGRHLALGIAERVgen..EKVLICDAA.....IASD.DIVNIL
  49 .AAGLHE.E.....WSPks.ESSREVLRYLLDSGVag...KRIAVQLHGaadgwDPFP.EFINGL
  50 .EHGLRV.D.....IVPe..DYTAEGLLDALTGLNieg..WKVALPRTL.....SARK.VLPRGL
  51 .RHSLDA.K.....VVSt..DGTMQNLLYSLQSVIggns.KTVFLQTYN.....EDDI.VLKEKL
  52 .AGGATV.C.....QPSs..RFDGEALAEAINQWQgkg..RHFLFPRAA.....IGRE.TLIDGL
  53 .AAGLTA.D.....WVAe..SETSAEIADVLLGEGvag..LRIAVQHHG.....AGAD.GLDVVF
  54 .EAMKSA.Dgl6vaFTPs..KATGKVLASELPEKVgkr..SSVLYPASL.....KAGN.DIVEGL
  55 .EAMKSA.Dgl6vaFTPs..KATGKVLASELPEKVgkr..SSVLYPASL.....KAGN.DIVEGL
  56 .SLGIRV.D.....FMPn..DFSQEGFLESFNQTN.....QKILLPSSE.....LARP.LLSAAL
  57 .SLGIRV.D.....FMPn..DFSQEGFLKSFNQTN.....QKILLPSSE.....LARP.LLLAAL
  58 .SLGIRV.D.....FMPn..DFSQEGFLKSFNQTN.....QKILLPSSE.....LARP.LLLAAL
  59 kYFGRDP.D.....IMPn..EYTAESLLREIKKVSkee..EKFLIPTTP.....STRD.VLKNNL
  60 .EISLEA.Q.....QTTe..KPTTEGVIEMLGKLDlkgr.RLGLQLYPD.....KDHS.TLTGAL
  61 .EIGLCP.Q.....GEK...SGNAEKLAEYICSREgphs.SPLLFPCGA.....LKRE.VLPTAL
  62 .QRGLSV.D.....AVPe..HFSSEGLLDLPLLHQvtg..KTIAIFCGE.....NSRP.YLENEL
  63 .DAGFSD.V.....IVA...DGDAAKLRIKIRDTFsg7raGALLYLAGA.....DLSR.DLAGEL
  64 .KLGYKA.D.....FIPe..NESAKGLIELFKRLPk....GKVLIPRSK.....IGRT.ELIKFL
  65 .EAMKSA.Dgl6vaFTPs..KATGKVLASELPEKVgkr..SSVLYPASL.....KAGN.DIVEGL
  66 .EYGLAP.D.....FVPt..RSGSRHLGAELPAAPg....EVALHVGSQ.....DTDA.VLEMAL
  67 .DAGFAE.V.....IIA...GGDSAALRDTVVRSArd8kkSTLLYLAGA.....DLSR.DLGGEL
  68 .YYGISA.E.....IPQ...VETSEGMLQLPVFQMlksf.RQVAFWRGE.....GGRQ.LMMQQL
  69 .EIGLEP.Q.....VTAe..APTSEGVAATLKRYDlag..RRIGVQLYP.....ERDHaALLDSI
  70 .EFGLKPtH.....RVPe..PNTWRELLQTIDAGIpian.QTIGIQEYG.....VSNK.QLIAGL
  71 .ARGLPV.D.....FLPt..TATALSLGRKLPAQPg....QAALHLTSQ.....LSEN.TLRGEL
  72 .RCGFTD.V.....RGGse.TGNGVLLAELMLNMIqk8ssGTFLLLVGE.....IRRD.IIKKRL
  73 tHFHLEC.P.....NYG...ETSDELLVRAAEALRg....KRLVVSFYG.....AVDS.ELLEEL
  74 .ETGFEQ.I.....FTA...SGDALGLTVLVKQHRaf6eeEPLLYLAGR.....PRGS.VFEEGL
  75 .EAGVSV.K.....DAG...AGDADRLAERIVASVqpg..SKILLLCGR.....IRRG.TLESRL
  76 .DLSGRP.V.....LHPta.GSDSEALLALPELADasg..QRWLIVRGQ.....GGRP.LLADTL
  77 .MRGFTS.V.....IEG...PGDAEALADAIAAALpg...KAITYLCGR.....VRFA.MFEQRM
  78 .AGGLPP.A.....FLPp..RATAKDLAQSFPQA-.....QRVLFVAGD.....LAGR.DLEEGL
  79 .KYGYDC.E.....YPE...KMDSEGLADMIISHCsg...RKVALIRSA.....NANE.IVNEKI
  80 .SLGLTP.L.....GED...TGTAEVLARVIIEREdtni.PPLFFPCGS.....IKRE.VLPVAL
  81 .EAGWTV.D.....VVPe..EYTSAGLVAALDGDIdg...ARVEVARSD.....HGSA.VLTDGL
  82 .QYHLTP.D.....FIPp..NFIADQLIDHFPESLkhq..KILFPRVET.....GGRE.ILVK--
  83 .DLGFTD.V.....RIG...PGTGEGLAETVAALLppg..ETLVYLAGS.....PRTD.GFERAL
  84 .EAMKSA.Dgl6vaFTPs..KATGKVLASELPEKVgkr..SSVLYPASL.....KAGN.DIVEGL
  85 nAFGVEP.Q.....LVAd..--SAEELARLIESC-.....RVATVFHHG.....ERAE.ELMKRL
  86 .AAGLAA.H.....S--a..EGDAERLIAAILAADep...GPLLHLRGA.....ESRG.EVAPRL


             160       170           180        190       200          
              |         |             |          |         |          
   1 AERGYRVLPLMPYRHLPDPE....GILRLEEALLRGEVDA.LAFVAAIQVEFLFEGAKDPKAL..
   2 RERGWEIEDVTAYRTVRAAP....PPAETREMIKTGGFDA.VCFTSSSTVRNLVGIAGKPHA-..
   3 RERGWEIEDVTAYRTVRAAP....PPATTREMIKTGGFDA.VCFTSSSTVRNLVGIAGKPHA-..
   4 RERGWEIEDVTAYRTVRAAP....PPATTREMIKTGGFDA.VCFTSSSTVRNLVGIAGKPHA-..
   5 VALGWEVDDVVAYRTVRAAP....PSADIRDMIKTGGFDA.VCFTSSSTVRNLVGIAGKPHP-..
   6 THLGWEVEDVVAYRTVRAAP....PSADIRDMIKTGGFDA.VAFTSSSTVKNLVGIAGKPHP-..
   7 THLGWEVEDVVAYRTVRAAP....PSADIRDMIKTGGFDA.VAFTSSSTVKNLVGIAGKPHP-..
   8 VNLGWEVDDVVAYRTVRAAP....PSAEVRDMIKSGDFDA.VCFTSASTVRNLVGIAGKPHA-..
   9 THLGWEVEDVVAYRTVRAAP....PSADIRDMIKTGGFDA.VAFTSSSTVKNLVGIAGKPHP-..
  10 IELGWEVDDVTAYRTVRASP....PPAETREAIKGGGFDA.VLFTSSSTVRNLVGIAGKPH--..
  11 RGCGWEIEDVTAYRTVRAAP....PPAATREMIKTGGFDA.VCFTSSSTVRNLVGIAGKPHA-..
  12 ARAGARVDVLPVYETVPGDA....NRSHVLEMLEEGRIDC.ITFGSSSTVDNFFSLVEPEAM-..
  13 IELGWEVDDVTAYRTVRASP....PPATTREAIKGGGFDA.VLFTSSSTVRNLVGIAGKPH--..
  14 VNLGWEVDDVTAYRTVRAAP....PPAPIREAIKGGGFDA.VMFTSSSTVRNLVGIAGKPHA-..
  15 RKAGATVDVLPVYVTVPSAA....RRDDVLARMEAGEVHC.VTFGSSSTVENFFSLVPADTV-..
  16 QENGWEVDDVTAYRTVRAAP....PAAPVRDAIKTGAFDA.VVFTSSSTVRNLVGIAGKPHP-..
  17 RRQGAEVTEVTAYRTVKNEE....NAGSLKEMLAAGKVAA.VTFTSSSTVRAFLDLLGDGAL-..
  18 AELGGEVTAPVAYRNVTPDS....LPAGVIAELEERRITC.VTFTSSSTVENLAAILGENRF-..
  19 RGAGAQVTVAPVYVTKPIAE....NKKEMRAELESGTVDM.VTFTSSSTVTNFIKMLQPESPEe.
  20 SQKQALVTEVPSYQSACPGH....MPEEVWQSIVNQTVDV.ITFASSKTVSHFRQLLAQTSQAng
  21 QTLGAEVWDVPVYKTVSGSA....NKGLLKSMLEDKQIQA.VTFTSSSTVRNFCRLIDNQT--..
  22 KALGADVWDVPTYRTVLGNA....NKEELMKLLEEKAVAA.VTFTSSSTVRNFLQLIDGRQ--..
  23 TLKGAKVIEVAAYQSCCPSS....IPSGAELALQNHNVNV.ITFASSKTVQFFYQLTEKIFSQns
  24 QTLGAEVWDVPVYKTVSGSA....NKGLLKSMLEDKQIQA.VTFTSSSTVRNFCRLIDNQT--..
  25 SELGWEVEDVVGYRTVRAAP....PPAETREAIKTGKFDA.VVFTSSTTVRNLVGIAGKPHK-..
  26 KE--CEVTDLVVYQTIRNQDs...--ERLVKQHVETGIDA.ITFTSSSTVRFFVESVKDIPNW..
  27 EEKGASVLPILPYQHIPPEEe...TVERLCRELMNDEVDA.VCFTTAIQVRSLFDFAKGRGYIne
  28 EKCGATVYETHVYTLSIPEGt...IQKDLIERTLAGEVDA.FAFTSSMMVKGFMKHAKGLGAEet
  29 GEAGVRVVEVAAYESRCPDA....MPERTAEALEAGTVDA.ILFSSGKTAAHTAQLLLQRFGPg.
  30 RAGGAEVVGVPVYRWMPPEDit..PVDRLLDATVTRGLDA.ITFTSAPAAASLLSRAEERGLLsd
  31 EKCGATVYETHVYTLSIPEGa...AQKELIERTLSGEVDA.FAFTSSMMVRGFMKHAENLGASea
  32 LEQGALYTELLPYRHIAPDEe...TLATLYKEIVGREVDA.VCFTSAMQVRFFFSFAREKKEIap
  33 LERGASYTELLPYRHVAPDEk...TLETLYNEVVGREVDA.VCFTSAMQVRFFFSFAREKKEIap
  34 RESGAHVIEVAAYESRCPEA....IPDDTATALANSNVDA.IAFSSGKTAAHTASLLSHRFGSd.
  35 AERGYRVLPLMPYRHLPDPE....GILRLEEAVLRGEVDA.LAFVAAIQVEFLFEGAKDPKAL..
  36 REGGAEVVGVPVYRWLPPEDlg..PVDRLLDAAVSRGVDA.VTFTSAPAAVSLLGRAEERGLLpe
  37 REMGAEVEVAPAYRTICGQV....DGEALAAELKEGNIDL.VTFTSSSTVKNLVNIIGS----..
  38 AEFGGTCVELTVYENLPPSLe...DTQRVKDMLAEGKLDC.LSFTSPSTAKNFFEAIGS----..
  39 LAEVEAMEMMPLYDMRPVTE....RPFDLA------SFEQ.VCFSSSRSVQNLLDVLTTEE--..
  40 LAEVEAMEMMPLYDMRPVTE....RPFDLA------SFEQ.VCFSSSRSVQNLLDVLTTEE--..
  41 EEKGADIQTLLPYRHTPAKEe...TMAQFFQEIEERAFDA.VCFTAAIQVRELFTYAKKNNMKdl
  42 AKRGGICVELTVYDNIQPSLe...ETQKIKSLLTEGKIDC.LSFTSPSTAINFFEAIDS----..
  43 EQCGATVYETHVYTLSIPEGa...AQKELIERTLAGEVDA.FAFTSSMMVRGFMKHAEKLGAKdt
  44 LADVKAIEMMPLYDMRPVTE....RPFDLE------SFEQ.VCFSSSRSVQNLLDVLTIEE--..
  45 VPLGFEVKEWVLYETIPDEE....GIEALKDAAGQYSFDY.VTFTSSSTVHTFMHVLGEELKK..
  46 RAAGARVRGVSVYRWLPPADpv..AVERLVDLVATRRLDA.VTFTSAPGALALLEVARRQGRLde
  47 RFAGAQVVPIRVYRWKPAPLgg..VFDHLVTGIARRQFDA.VTFTSAPAAAAVLERSRELDIEdq
  48 RSNNIKFDRVPLYNTNYINE....NSNKVKKSIVHGELKY.ITFTSASTVEGFIASMKDIPL-..
  49 RSAGAQVMPIHVYRWKPTPAgg..EFDQLVASVARRQFDA.VTFTSAPAGAALLERSRELGIEdq
  50 EMMGAEVLVAEAYRSGLPEDtg..PAEELIDGLLDGKVDA.VTFTSPLTVENLFKIAGNRRKE..
  51 ENLGCNVYMSKPYRYRNPDKe...TIAKLESNIVEQNLEA.VIFTSKTQVKNLFQMASDTALL..
  52 ENDDHRVTMVAAYRALPAQQ....LSAQAHRYLREKRVDA.ALFFSSRTATTFFELLISQALE..
  53 AEAGAEVASLVVYRWGPPPDpe..ALRASVEAAAVGEIDA.VVFTSAPGAEAWLSAAEEHGVGrl
  54 SKRGFEVVRLNTYTTVPVQS....VDTVLLQQALSAPV--.LSVASPSAVRAWLHLIQNEEQW..
  55 SKRGFEVVRLNTYTTVPVQS....VDTVLLQQALSAPV--.LSVASPSAVRAWLHLIQNEEQW..
  56 SE-DNEVVKIDLYTSVPNKQ....NIQDVKEMIEHQQIDA.LTFSSSSAVRYYFNEGFVPK--..
  57 SK-DNEVVKIDLYTSVPNKQ....NIQDVKEMIEHQQIDA.LTFSSSSAVRYYFNEGFVPK--..
  58 SK-DNEVVKIDLYTSVPNKQ....NIQDVKEMIEHQQIDA.LTFSSSSAVRYYFNEGFVPK--..
  59 N-----ADLLFVYKSAEPENlke.DIKKLKELIAKDKF-I.LTFTSGLTAKNFFKYVDDEF--..
  60 SAQGAEVDTVLPYVYDSKAAda..NIVAAIDDMAEGRIDS.IALTNLGQVRRLIEAAKAHGSEak
  61 KEKGIPLESLTVYQTAQHEH....LQQSLSSYFSQQGVPAsIVFFSPSGVKFCLQHIQKLSG-..
  62 IHRGANVFSIITYRRERP-V....VNKKTIDALTHQTLHA.IVSTSAESLQNLCTLFESHQ--..
  63 REDGFDVVMQTAYRMVPLPS....LPADVCDAFAANRIEA.VLHYSRRSARAFIDATRTSGIE..
  64 KETSFEVFALDVYTTEYVFY....TREELLEKLNKGDF--.IIFYSPSAVKAFFANLQMHKIP..
  65 SKRGFEVIRLNTYTTVPVQS....VDTVLLQQALSAPV--.LSVASPSAVRAWLHLIQNEEQW..
  66 SARGIEYVAAEAYRSELSEL....TPAQREQL---QEAQV.VTLASAVGARALAQVAGT----..
  67 GTEGFNVVTQTTYRMAPVKV....LPRDVCEGFAAHGIEA.VLHYSRRSARAFLDAARDEGVE..
  68 IDQGVHLLNFILYDRQCPESatqkILSIAHDIVQDKQPVW.VLITSEASWLNWLSLIQPHA--..
  69 TAQDATVDAVLPYSYDARAAeq..TVVTAVEEMAQGRVDA.LALTSSGQVRRLFDVARAHDCEdr
  70 EARGAIAESVKVYGWEFPEDtq..PLKANTLALAEGERDI.LLVTSAHQVVNLLRMAEDLGVSds
  71 AARGVTYRRLELYHTAPAVL....---NAAERVALAGVSA.VTLASGSAAQGLAALAGPDFDP..
  72 ESAELEVEEIITYRTSPLHD....ISERFERVFTDNSW--.VVLFSPQGTNELLPLLRQ----..
  73 RKIAADVKYVQVYTTEEAPEa...NALEAARRFLEGN-HI.LIFTSALGAEAFLKAVERAGILre
  74 AAAGIPFRTVDCYEMLPSDI....SENTLETTLLDTTADM.VLLYSSEAARAFFHHVSADKY-..
  75 AAAGLPVRAIETYDTVPVSL....SGDELSTEIGDRSIDA.VLVYSAVAATILSPFVSSFL--..
  76 AARGAEVGVAEVYRRVDGAPd...-----WAAFDAAPPDA.VIITSGEMVEQLFRLAGPRR--..
  77 EAAGVRVRAVETYDTLPVPY....SDGTILALLSGQPVDA.VLLYSAKAAAAMQALTKRPAL-..
  78 RARGVEVVRLPVYATRERAL....APEEVA-LL--ERAEV.VAFFSPSGVRAFARWTAK----..
  79 MG-HVDFIDLRNYRAVNTN-....--VDLTPYMAKEECMG.IIVTSSMEAKIAMPAIKAT---..
  80 RESGVPLETLTVYQTAEHPD....LEKNLRNYFTEQGVPAsVAFFSPSGVKFCLEVVRRLSG-..
  81 AEAGAYVHETVLYALTRPAGa...--GDSTEIAAAGDLDA.ALFTSSLTVEHWLAAARERGIEsa
  82 --------------------....----------------.----------------------..
  83 HQRRIEHRTAECYRMAPVHY....PAETLPGLLRAGPFDA.VMLYSRESARRLDAALRESGLE..
  84 SKRGFEVVRLNTYTTVPVQS....VDTVLLQQALSAPV--.LSVASPSAVRAWLHLIQNEEQW..
  85 SSLCSRAYEFFTYRAVPDDE....----ALRALPPGEV--.YVFFSALAAELVAARRRD----..
  86 AAAGLTAAEAVVYDQRPQPL....-SSEARALLTDGAPVI.APLFSPRTARLLAQELARIG--..


        210       220       230       240         250       260 
         |         |         |         |           |         | 
   1 ...REALNTRVKALAVGRVTADALREWGVKPFYVD..ETERLGSLLQGFKRALQKEVA
   2 ...------RTIIACIGPKTAETAAEFGLRVDVQP..ETAAVGPLVDALAE-------
   3 ...------RTIIACIGPKTAETAAEFGLRVDVQP..DTAAIGPLVDALAE-------
   4 ...------RTIIACIGPKTAETAAEFGLRVDVQP..DTAAIGPLVDALAE-------
   5 ...------RTIIACIGPMTADTARELGLRVDVMP..EIAEVPDLVDALADH------
   6 ...------RTIVACIGPMTAATAEELGLRVDVMP..EIAEVPELIDALAEH------
   7 ...------RTIVACIGPMTAATAEELGLRVDVMP..EIAEVPELIDALAEH------
   8 ...------RTIIACIGPMTAAEAEKQGLRVDVIP..EVANVAALVDALAEHV-----
   9 ...------RTIVACIGPMTAATAEELGLRVDVMP..EIAEVPELIDALAEH------
  10 ...-----NVTVIACIGPATAKTAEEHGLRVDVMA..PEPSVLKLAEALAD-------
  11 ...------RTVIACIGPKTAETASEFGLRVDVQP..ETAAVGPLVDALAEH------
  12 ...--RRYEHVHMACIGPVTRKTLERYGFTCSIQP..EDYTIPALVDELVR-------
  13 ...-----NVTVIACIGPATAKTAEEHGLRVDVMS..PEPSVTKLAEALAD-------
  14 ...------TTVIAVIGPETAKTAEEFGLRVDVRA..PKASVAALAEALAE-------
  15 ...--KAHPEVKLACIGPVTKKTLEGFGFTCHIQP..DDYTIPALVDELTR-------
  16 ...------STVVACIGPATAKTAEEHGLRVDVLA..PEPSADALVDALA--------
  17 ...--DLVQGIDVFCLGPVTAATAREAGLQVAATA..GEYTEEGLVRAMENY------
  18 ...-LHLLKGVTIAAIGPITARTCRELGLEVHVEP..SKYTLAAMTDALVDF------
  19 ...LASLLKGVRIAAIGPITAKTVTDNGLQVDVQP..ENYTIAGMLDAIVESY-----
  20 yqdWRSLINHCQIASIGPQTSERCLRELGRVDIEA..TEYTLEGLTGAITNY------
  21 ...--ELLDGVKLFSIGPLTSAAARELGLPIHKEA..ARSTIDGLVAALV--------
  22 ...--SLLDGVKLYSIGPITSKTAQEFGLSIYREA..KQYTIKGLLETLA--------
  23 d..VSQLLENVCIASIGPQTSKTCHDLFGRVDVEA..QEYTLDGLTQAL---------
  24 ...--ELLDGVKLFSIGPLTSAAARELGLPIHKEA..ARSTIDGLVAALV--------
  25 ...------HTVVAAVGMRTAETCREHGLTVDVIA..PEPTALSLADALADF------
  26 ...-LELINRTKVVCIGPITSQTASEYGIKH-LVP..NTYTINGMIDMLV--------
  27 v..KKVFEERAIAAAVGKVTAEALREEGITRLLAP..EIERMGAMIVELAKYY-----
  28 ...IKESLSRAVVGAIGTPTGNTLNKYGVNANVIP..EEFTFEALIKAMKK-------
  29 ...WEQRLETLKLVSIGPQTSRSCREWFGRIDAEA..DPHDLEGLVSAC---------
  30 v..LAALHHDVLPACVGPVTALPLQARGVDT-VQP..ERFRLGPLVQLLCKEL-----
  31 ...VKEILSRAVVGAIGTPTGNTLKKHGVNANVIP..DEFTFEALIKAMKK-------
  32 l..LDAFRTDVVACAVGKVTKEALEEEGVDRVIAP..EHERMGAMIVTLARYF-----
  33 l..LDAFRTDVVACAVGKVTKEALEEEGVDRVIAP..EHERMGAMIVTLARY------
  34 ...WLQQLETVKVISIGPQTSLSCEQHFGRVDQEA..DPHNLEGLISACVKACRS---
  35 ...REALNTRVKALAVGRVTADALREWGVKPFYVD..ETERLGSLLQGFKRALQKE--
  36 l..LAAFGHDVLPACVGPVTAVPLQAHGVDT-VQP..ERFRLGPLVQLLCQE------
  37 ...-AEVLKGVKTACIGPVTADTAKSLGIEPDIIA..KEYTIDGLVEAIC--------
  38 ...-KELSDSVQIAAIGTTTSGALEKMGIKVDIIP..EYFDGPSFAKAIAEA------
  39 ...-KAILQTKTILSIGRFTSATLASFGINNFIEA..ESATPESLIELIQK-------
  40 ...-KAILQTKTILSIGRFTSATLASFGINNFIEA..ESATPESLIELIQK-------
  41 l..VEAFQRHVIAVSVGKVTTEALQDEGIKRIVAP..KLERMGAMIVALASYVQE---
  42 ...-KEVPSDVLIAAIGTTTSSALEKLGVKVDIIP..EYFDGPNFAKAIA--------
  43 ...IKETLSRAVVGAIGTPTGNTLEKYGVNADVIP..EEFTFEALVKAMKKTMKNQ--
  44 ...-KAILQTKTILSIGRFTSATLASFGMNNFIEA..ESATPESLIELIQK-------
  45 ...WKAN--GTACISIGPLTNDALLTYGITS-HTP..DTFTIDGMLELMCSM------
  46 v..VAACGNGVVACAVGDVTAEPLRAVGVEP-LIP..DRWRLGALLRTLTTHL-----
  47 l..LAALRTDVHAMCVGPVTSRPLIRKGVPT-SAP..ERMRLGALARHIAEE------
  48 ...-----ESLTAVCIGNKTAEAAKKYNLRY-VVA..EKSTIDSMIDKLLEIG-----
  49 l..LQALRSDVHAMCVGPVTAQPLIRAGVPT-SSP..ERMRLGALARHIAQ-------
  50 ...LIEVLKRVKVAAIGPITLRKLEEHGITA-VTP..ERYTVKDMIAALAVSMGEDV-
  51 ...TEAFNKHVTAVAVGKVTANQLNQYGVSRVVQP..ANQKMGAMVIELRDYLL----
  52 ...PA----EMVLAALSPVTAERMASLGFAAHVIA..PQATAESLLQALADHW-----
  53 vv.SRFQDGSMVAAAVGPVTARPLEHRGVTP-LQP..ERGRLGALVRTLVAHY-----
  54 ...------SNYVACIGETTASAARRLGLKNVYYP..EKPGLEGWVESIMEAL-----
  55 ...------SNYVACIGETTASAARRLGLKNVYYP..EKPGLEGWVESIMEAL-----
  56 ...------FKSYFAIGEQTARTIKSYQQPV-TIA..EIQTLESLIEKIL--------
  57 ...------FKSYFAIGEQTARTIKSYQQPV-TIA..EIQTLESLIEKIL--------
  58 ...------FKSYFAIGEQTARTIKTYQQPV-TIA..EIQTLESLIEKIL--------
  59 ...-AEIIKDNYIVAIGPITAKVIEKFGFKP-LIP..KVYTIEGMLEVI---------
  60 ...LRAGLERTLIASVGPAVSGELAAHGLRTDIAPaeDAYFMRPLISAMAAAL-----
  61 ...--DFANRIKFAAIGPTTAEAMEAAGIPVSCTA..ESSTPQDLTAGIQKAL-----
  62 ...--HWLHRIPLVVISKRMENLAKSQGFHLVLLA..DNPGEKAIIKVL---------
  63 ...ISAL--AIPQCCLSEAVSEVVREAGANQVMVA..RKPDEKALLEALDRAL-----
  64 ...KDSL--SLKFVAIGKTTKEELQKHSVKNVITS..ERPSTEDIVKKLKE-------
  65 ...------SNYVACIGETTASAARRLGLKNVYYP..EKPGLEGWVESIMEAL-----
  66 ...------SFTAAVIGPQTELAAREAGFTRLILA..EQPTLASLSDAVQR-------
  67 ...ISAL--AIPQCCLSETVASVLRDAGASQVLVA..AKPDENALFDTLERALQ----
  68 ...--GLFQDCHYLVLGERLEQILTIYQNQHQLSF..NMIRLENL-------------
  69 ...LRDGLSRTPIASVGPVVTEELAAHGFAPTITPanEAFFMKPLINAMIVAL-----
  70 ...LRDGLSKTAIVSIGPTTSDMLREHDLAIAMEP..SHPKMGHLV------------
  71 ...---L--RLPVAAIGEQTAAAAWTLGFVSVTTA..PQPSLEGLVA-----------
  72 ...-----GAAKIAAIGPTTAQYLLDNATPPILTS..PKPEPSSLCNAIKDYL-----
  73 vv.ETANSGRSVIAVVGPVTEQEVRKYGVTRVIVP..EKPFLAYLAEAVAEFLNKAL-
  74 ...-VTALAATKFICISRNVLFLVPEIFRANAKAA..EEPSEAAMFELL---------
  75 ...------TAAFIAISDRVAQNLPAGLGNRIHIA..REPTEDAMLSLL---------
  76 ...-TGALQCLLYCVPHPRIAERLAAFGAAR-IVT..TRADDAALVAGLKEWF-----
  77 ...-QEAFEKTQVFALSARIAAAFGGGAGKAIRIA..ARPDGEALLAL----------
  78 ...------RPKAAAIGPSTGEEARRLGFPV-VEA..ESPGLEGLFAALLRA------
  79 ...------GKPVYSIGSVTTKTLEEAGIHP-AIS..GNSDFVDLVEKIKKYL-----
  80 ...--EQLPQIKFAAIGPTTEEAMAAEGLRV----..---------------------
  81 ...AREGLADATVGAIGPPTAETAADHGISVDVVP..DDAGFEALA------------
  82 ...--------------------------------..---------------------
  83 ...PADLASR--FLCLSWPIRETLPD-GLPC-GVA..AVPDEENL-------------
  84 ...------SNYVACIGETTASAARRLGLKNVYYP..EKPGLEGWVESIMEAL-----
  85 ...---VLERAVIIAAGPAVKAALEKHGLNA-AVP..PSGRIGEVALFVK--------
  86 ...---GTGPLWVAAMSPAVAEAAAALPVARLSVA..ARPDAEALLQAVKALLDA---