a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0262 1wfx, Aeropyrum pernix
- gi|14600528|ref|NP_147045.1|_1:256 hypothetical protein APE0204 [Aeropyrum pernix K1]
- gi|7515628|pir||B72777 hypothetical protein APE0204 - Aeropyrum pernix (strain K1) [Taxonomy]
- gi|5103595|dbj|BAA79116.1| 256aa long hypothetical protein [Aeropyrum pernix K1]
- gi|30316396|sp|Q9YFP5|KPTA_AERPE_3:220 Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|16082485|ref|NP_393596.1|_2:213 Uncharacterized conserved protein [Thermoplasma acidophilum DSM 1728]
- gi|30316365|sp|P57718|KPTA_THEAC Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|48839767|ref|ZP_00296697.1|_8:205 COG1859: RNA:NAD 2'-phosphotransferase [Methanosarcina barkeri str. fusaro]
- gi|13541027|ref|NP_110715.1|_2:211 Uncharacterized conserved protein [Thermoplasma volcanium GSS1]
- gi|30316106|sp|Q97CA6|KPTA_THEVO Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|14324410|dbj|BAB59338.1| hypothetical protein [Thermoplasma volcanium GSS1]
- gi|30316072|sp|Q8U4K2|KPTA_PYRFU_4:181 Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|20093417|ref|NP_619492.1|_8:205 conserved hypothetical protein [Methanosarcina acetivorans str. C2A]
- gi|25008686|sp|Q8TH84|KPTA_METAC Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|19918789|gb|AAM07972.1| conserved hypothetical protein [Methanosarcina acetivorans str. C2A]
- gi|22970562|ref|ZP_00017625.1|_23:202 hypothetical protein [Chloroflexus aurantiacus]
- gi|21227400|ref|NP_633322.1|_8:204 putative tRNA 2'phosphotransferase [Methanosarcina mazei Go1]
- gi|25008685|sp|Q8PXC3|KPTA_METMA Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|20905763|gb|AAM30994.1| putative tRNA 2'phosphotransferase [Methanosarcina mazei Goe1]
- gi|14590098|ref|NP_142162.1|_3:173 hypothetical protein PH0160 [Pyrococcus horikoshii OT3]
- gi|12230226|sp|O57899|KPTA_PYRHO Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|7518499|pir||F71237 hypothetical protein PH0160 - Pyrococcus horikoshii [Taxonomy]
- gi|3256546|dbj|BAA29229.1| 177aa long hypothetical protein [Pyrococcus horikoshii OT3]
- gi|18314222|ref|NP_560889.1|_14:208 conserved hypothetical protein [Pyrobaculum aerophilum str. IM2]
- gi|30316096|sp|Q8ZSP2|KPTA_PYRAE Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|18161816|gb|AAL65071.1| conserved hypothetical protein [Pyrobaculum aerophilum str. IM2]
- gi|23129655|ref|ZP_00111481.1|_3:179 COG1859: RNA:NAD 2'-phosphotransferase [Nostoc punctiforme]
- gi|30065412|ref|NP_839583.1|_23:216 hypothetical protein S4443 [Shigella flexneri 2a str. 2457T]
- gi|30043674|gb|AAP19394.1| hypothetical protein S4443 [Shigella flexneri 2a str. 2457T]
- gi|34497880|ref|NP_902095.1|_31:204 conserved hypothetical protein [Chromobacterium violaceum ATCC 12472]
- gi|34103736|gb|AAQ60097.1| conserved hypothetical protein [Chromobacterium violaceum ATCC 12472]
- gi|19704437|ref|NP_603999.1|_5:177 tRNA 2'phosphotransferase [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
- gi|30316068|sp|Q8R5N7|KPTA_FUSNN Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|19714699|gb|AAL95298.1| tRNA 2'phosphotransferase [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
- gi|11498018|ref|NP_069242.1|_11:205 conserved hypothetical protein [Archaeoglobus fulgidus DSM 4304]
- gi|12230220|sp|O29841|KPT1_ARCFU Probable RNA 2'-phosphotransferase 1 [Taxonomy]
- gi|7450140|pir||F69300 conserved hypothetical protein AF0406 - Archaeoglobus fulgidus [Taxonomy]
- gi|2650225|gb|AAB90829.1| conserved hypothetical protein [Archaeoglobus fulgidus DSM 4304]
- gi|24115391|ref|NP_709901.1|_7:199 orf, conserved hypothetical protein [Shigella flexneri 2a str. 301]
- gi|24054700|gb|AAN45608.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301]
- gi|34763031|ref|ZP_00144006.1|_6:177 tRNA 2'phosphotransferase [Fusobacterium nucleatum subsp. vincentii ATCC 49256]
- gi|27887291|gb|EAA24387.1| tRNA 2'phosphotransferase [Fusobacterium nucleatum subsp. vincentii ATCC 49256]
- gi|21222358|ref|NP_628137.1|_4:176 possible phosphotransferase [Streptomyces coelicolor A3(2)]
- gi|12230327|sp|Q9ZBX9|KPTA_STRCO Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|7481186|pir||T36059 probable phosphotransferase - Streptomyces coelicolor [Taxonomy]
- gi|3928729|emb|CAA22225.1| possible phosphotransferase [Streptomyces coelicolor A3(2)]
- gi|49176491|ref|NP_418751.3|_23:216 2'-phosphotransferase [Escherichia coli K12]
- gi|1361157|pir||S56556 hypothetical 24.6K protein (iadA-mcrD intergenic region) - Escherichia coli (strain K-12) [Taxonomy]
- gi|537172|gb|AAA97227.1| ORF_o218 [Escherichia coli]
- gi|1790787|gb|AAC77287.1| 2'-phosphotransferase [Escherichia coli K12]
- gi|18309126|ref|NP_561060.1|_7:179 conserved hypothetical protein [Clostridium perfringens str. 13]
- gi|25008687|sp|Q8XP22|KPTA_CLOPE Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|18143801|dbj|BAB79850.1| conserved hypothetical protein [Clostridium perfringens str. 13]
- gi|14520375|ref|NP_125850.1|_8:179 putative phosphotransferase [Pyrococcus abyssi GE5]
- gi|12230319|sp|Q9V2B7|KPTA_PYRAB Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|7521312|pir||B75204 probable phosphotransferase PAB2247 - Pyrococcus abyssi (strain Orsay) [Taxonomy]
- gi|5457590|emb|CAB49081.1| Probable RNA 2'-phosphotransferase [Pyrococcus abyssi]
- gi|28871904|ref|NP_794523.1|_3:182 RNA 2'-phosphotransferase [Pseudomonas syringae pv. tomato str. DC3000]
- gi|31563082|sp|Q87VZ5|KPTA_PSESM Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|28855157|gb|AAO58218.1| RNA 2'-phosphotransferase [Pseudomonas syringae pv. tomato str. DC3000]
- gi|47207136|emb|CAF90715.1|_10:227 unnamed protein product [Tetraodon nigroviridis]
- gi|15225454|ref|NP_182058.1|_29:255 tRNA 2'phosphotransferase, putative [Arabidopsis thaliana]
- gi|25408946|pir||C84889 hypothetical protein At2g45330 [imported] - Arabidopsis thaliana [Taxonomy]
- gi|2583121|gb|AAB82630.1| unknown protein [Arabidopsis thaliana]
- gi|29028854|gb|AAO64806.1| At2g45330 [Arabidopsis thaliana]
- gi|15891357|ref|NP_357029.1|_5:175 AGR_L_2490p [Agrobacterium tumefaciens str. C58]
- gi|17937290|ref|NP_534079.1| conserved hypothetical protein [Agrobacterium tumefaciens str. C58]
- gi|30316073|sp|Q8U9Z2|KPTA_AGRT5 Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|25520148|pir||D98286 probable RNA 2'-phosphotransferase [imported] - Agrobacterium tumefaciens (strain C58, Cereon) [Taxonomy]
- gi|25524258|pir||AE2997 conserved hypothetical protein Atu3583 [imported] - Agrobacterium tumefaciens (strain C58, Dupont) [Taxonomy]
- gi|15159744|gb|AAK89814.1| AGR_L_2490p [Agrobacterium tumefaciens str. C58]
- gi|17741993|gb|AAL44395.1| conserved hypothetical protein [Agrobacterium tumefaciens str. C58]
- gi|46315039|ref|ZP_00215623.1|_12:188 COG1859: RNA:NAD 2'-phosphotransferase [Burkholderia cepacia R18194]
- gi|18976455|ref|NP_577812.1|_2:168 hypothetical protein PF0083 [Pyrococcus furiosus DSM 3638]
- gi|18891993|gb|AAL80207.1| hypothetical protein [Pyrococcus furiosus DSM 3638]
- gi|49081780|gb|AAT50290.1|_4:180 PA0054 [synthetic construct]
- gi|15595252|ref|NP_248744.1|_4:180 conserved hypothetical protein [Pseudomonas aeruginosa PA01]
- gi|12230262|sp|Q9I778|KPTA_PSEAE Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|11347608|pir||D83638 conserved hypothetical protein PA0054 [imported] - Pseudomonas aeruginosa (strain PAO1) [Taxonomy]
- gi|9945877|gb|AAG03444.1| conserved hypothetical protein [Pseudomonas aeruginosa PAO1]
- gi|45527160|ref|ZP_00178361.1|_5:178 COG1859: RNA:NAD 2'-phosphotransferase [Crocosphaera watsonii WH 8501]
- gi|10639263|emb|CAC11265.1|_3:187 conserved hypothetical protein [Thermoplasma acidophilum]
- gi|48859010|ref|ZP_00312952.1|_8:179 COG1859: RNA:NAD 2'-phosphotransferase [Clostridium thermocellum ATCC 27405]
- gi|32476856|ref|NP_869850.1|_5:180 RNA 2-phosphotransferase [Pirellula sp. 1]
- gi|32447404|emb|CAD78993.1| RNA 2-phosphotransferase [Pirellula sp.]
- gi|29123124|gb|AAO62941.1|_8:222 tRNA splicing 2' phosphotransferase 1 [Homo sapiens]
- gi|12231009|sp|P39380|KPTA_ECOLI_5:182 RNA 2'-phosphotransferase [Taxonomy]
- gi|50119352|ref|YP_048519.1|_6:178 RNA 2'-phosphotransferase [Erwinia carotovora subsp. atroseptica SCRI1043]
- gi|49609878|emb|CAG73313.1| RNA 2'-phosphotransferase [Erwinia carotovora subsp. atroseptica SCRI1043]
- gi|20094870|ref|NP_614717.1|_10:223 RNA:NAD 2'-phosphotransferase [Methanopyrus kandleri AV19]
- gi|30316079|sp|Q8X261|KPTA_METKA Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|18152922|gb|AAL61957.1| putative phosphotransferase [Methanopyrus kandleri]
- gi|19888100|gb|AAM02647.1| RNA:NAD 2'-phosphotransferase [Methanopyrus kandleri AV19]
- gi|49477941|ref|YP_037101.1|_6:180 probable RNA 2'-phosphotransferase [Bacillus thuringiensis serovar konkukian str. 97-27]
- gi|49329497|gb|AAT60143.1| probable RNA 2'-phosphotransferase [Bacillus thuringiensis serovar konkukian str. 97-27]
- gi|46125193|ref|XP_387150.1|_20:254 hypothetical protein FG06974.1 [Gibberella zeae PH-1]
- gi|42553591|gb|EAA76434.1| hypothetical protein FG06974.1 [Gibberella zeae PH-1]
- gi|19115427|ref|NP_594515.1|_10:221 putative phosphotransferase [Schizosaccharomyces pombe]
- gi|7492829|pir||T38523 probable phosphotransferase - fission yeast (Schizosaccharomyces pombe) [Taxonomy]
- gi|2414623|emb|CAB16372.1| SPAC2C4.12c [Schizosaccharomyces pombe]
- gi|49094418|ref|XP_408670.1|_969:1307 hypothetical protein AN4533.2 [Aspergillus nidulans FGSC A4]
- gi|40741686|gb|EAA60876.1| hypothetical protein AN4533.2 [Aspergillus nidulans FGSC A4]
- gi|15237793|ref|NP_197750.1|_8:210 tRNA 2'phosphotransferase, putative [Arabidopsis thaliana]
- gi|8809699|dbj|BAA97240.1| unnamed protein product [Arabidopsis thaliana]
- gi|11499148|ref|NP_070382.1|_5:201 conserved hypothetical protein [Archaeoglobus fulgidus DSM 4304]
- gi|12230219|sp|O28719|KPT2_ARCFU Probable RNA 2'-phosphotransferase 2 [Taxonomy]
- gi|7450139|pir||H69443 conserved hypothetical protein AF1553 - Archaeoglobus fulgidus [Taxonomy]
- gi|2649007|gb|AAB89693.1| conserved hypothetical protein [Archaeoglobus fulgidus DSM 4304]
- gi|50421973|ref|XP_459547.1|_8:204 unnamed protein product [Debaryomyces hansenii]
- gi|49655215|emb|CAG87774.1| unnamed protein product [Debaryomyces hansenii CBS767]
- gi|48854387|ref|ZP_00308549.1|_5:179 COG1859: RNA:NAD 2'-phosphotransferase [Cytophaga hutchinsonii]
- gi|28575019|ref|NP_788477.1|_8:206 CG33057-PA [Drosophila melanogaster]
- gi|28380565|gb|AAO41267.1| CG33057-PA [Drosophila melanogaster]
- gi|32411257|ref|XP_326109.1|_26:298 hypothetical protein [Neurospora crassa]
- gi|28924498|gb|EAA33622.1| hypothetical protein [Neurospora crassa]
- gi|46439435|gb|EAK98753.1|_9:197 hypothetical protein CaO19.12887 [Candida albicans SC5314]
- gi|46439536|gb|EAK98853.1| hypothetical protein CaO19.5432 [Candida albicans SC5314]
- gi|6324470|ref|NP_014539.1|_7:201 Gene encodes a protein implicated in the last step of tRNA splicing in yeast: transfer of the splice junction 2'-phosphate from ligated tRNA to NAD; Tpt1p [Saccharomyces cerevisiae]
- gi|12230758|sp|Q12272|TPT1_YEAST tRNA 2'phosphotransferase [Taxonomy]
- gi|1077304|pir||S51897 hypothetical protein YOL102c - yeast (Saccharomyces cerevisiae) [Taxonomy]
- gi|663252|emb|CAA88160.1| orf [Saccharomyces cerevisiae]
- gi|1419957|emb|CAA99116.1| TPT1 [Saccharomyces cerevisiae]
- gi|45198857|ref|NP_985886.1|_8:199 AFR339Wp [Eremothecium gossypii]
- gi|44984886|gb|AAS53710.1| AFR339Wp [Eremothecium gossypii]
- gi|50547707|ref|XP_501323.1|_13:214 hypothetical protein [Yarrowia lipolytica]
- gi|49647190|emb|CAG81618.1| unnamed protein product [Yarrowia lipolytica CLIB99]
- gi|29830778|ref|NP_825412.1|_850:1057 hypothetical protein SAV4235 [Streptomyces avermitilis MA-4680]
- gi|29607891|dbj|BAC71947.1| hypothetical protein [Streptomyces avermitilis MA-4680]
- gi|50290283|ref|XP_447573.1|_4:188 unnamed protein product [Candida glabrata]
- gi|49526883|emb|CAG60510.1| unnamed protein product [Candida glabrata CBS138]
- gi|48843718|ref|YP_025290.1|_8:176 unknown [Neodiprion lecontei nucleopolyhedrovirus]
- gi|37694310|gb|AAQ99103.1| unknown [Neodiprion lecontei nucleopolyhedrovirus]
- gi|13899325|ref|NP_113660.1|_3:173 tRNA splicing 2' phosphotransferase 1 [Homo sapiens]
- gi|13477317|gb|AAH05133.1| TRNA splicing 2' phosphotransferase 1 [Homo sapiens]
- gi|23956404|ref|NP_705825.1|_3:173 tRNA splicing 2' phosphotransferase 1; EST-MNCb3719 [Mus musculus]
- gi|20380650|gb|AAH27575.1| TRNA splicing 2' phosphotransferase 1 [Mus musculus]
- gi|34861849|ref|XP_219539.2|_9:183 similar to tRNA splicing 2 phosphotransferase 1 [Rattus norvegicus]
- gi|50257963|gb|EAL20657.1|_6:334 hypothetical protein CNBE0230 [Cryptococcus neoformans var. neoformans B-3501A]
- gi|48843624|ref|YP_025197.1|_6:155 hypothetical protein [Neodiprion sertifer nucleopolyhedrovirus]
- gi|37626309|gb|AAQ96467.1| hypothetical protein [Neodiprion sertifer nucleopolyhedrovirus]
- gi|41719325|ref|ZP_00148229.1|_5:144 COG1859: RNA:NAD 2'-phosphotransferase [Methanococcoides burtonii DSM 6242]
- gi|46227921|gb|EAK88841.1|_9:216 similar to tRNA splicing 2' phosphotransferase [Cryptosporidium parvum]
- gi|45509240|ref|ZP_00161575.1|_3:95 COG1859: RNA:NAD 2'-phosphotransferase [Anabaena variabilis ATCC 29413]
- gi|32043193|ref|ZP_00140455.1|_6:94 COG1859: RNA:NAD 2'-phosphotransferase [Pseudomonas aeruginosa UCBPP-PA14]
- gi|15804907|ref|NP_290948.1|_23:101 Z5930 gene product [Escherichia coli O157:H7 EDL933]
- gi|25376638|pir||A91290 hypothetical protein ECs5289 [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952) [Taxonomy]
- gi|25376640|pir||F86131 hypothetical protein Z5930 [imported] - Escherichia coli (strain O157:H7, substrain EDL933) [Taxonomy]
- gi|12519345|gb|AAG59514.1| Z5930 gene product [Escherichia coli O157:H7 EDL933]
- gi|13364767|dbj|BAB38712.1| hypothetical protein [Escherichia coli O157:H7]
- gi|38704259|ref|NP_313316.2|_6:82 hypothetical protein ECs5289 [Escherichia coli O157:H7]
- gi|15807414|ref|NP_296147.1|_174:243 hypothetical protein [Deinococcus radiodurans R1]
- gi|12230312|sp|Q9RRR1|KPTA_DEIRA Probable RNA 2'-phosphotransferase [Taxonomy]
- gi|7472042|pir||A75274 hypothetical protein - Deinococcus radiodurans (strain R1) [Taxonomy]
- gi|6460252|gb|AAF11978.1| hypothetical protein [Deinococcus radiodurans]

              10        20        30        40        50        60     
              |         |         |         |         |         |     
   1 MPSSSQYRRYQDPHHPSIPTPTTLFSQPSLEILGGGVAEELPELALCCDGTVVEGRSNCRCKARA
   2 MPSSSQYRRYQDPHHPSIPTPTTLFSQPSLEILGGGVAEELPELALCCDGTVVEGRSNCRCKARA
   3 --------------------------------------EELPELALCCDGTVVEGRSNCRCKARA
   4 -----------------------------------------PELRTCHGPYRGRECPVCGKPGKI
   5 -----------------------------------------------HGYFRGGSCLQCKRPGRY
   6 -----------------------------------------PELRYCHGPYRGKECPVCGKPGKI
   7 -----------------------------------------------------------------
   8 -----------------------------------------------HGYFRGGSCQQCKRPGRY
   9 ----------------------------------------------------------------R
  10 -----------------------------------------------HGYFRGGSCQQCKRPGRY
  11 -----------------------------------------------------------------
  12 ----------------------------------------------------TESPTHCGVSAVK
  13 -----------------------------------------------------------------
  14 ---------------------------------------------------VNKNRKSRDENAMA
  15 -----------------------------------------------------------------
  16 -----------------------------------------------------------------
  17 -------------------------------------------------GFYRGEKCRCGAEGEL
  18 ----------------------------------------------------NKNRKSRDENAMA
  19 -----------------------------------------------------------------
  20 -----------------------------------------------------------------
  21 ---------------------------------------------------VNKNRKSRDENEMA
  22 -----------------------------------------------------------------
  23 -----------------------------------------------------------------
  24 -----------------------------------------------------------------
  25 -----------------------------------------------------SGRTGGRRRRGN
  26 ------------------------------------------------GYERDNDRRRPQGRGDG
  27 -----------------------------------------------------------------
  28 -----------------------------------------------------------------
  29 -----------------------------------------------------------------
  30 -----------------------------------------------------------------
  31 -----------------------------------------------------------------
  32 -----------------------------------------------------------------
  33 -----------------------------------------------------------------
  34 -----------------------------------------------------------------
  35 -----------------------------------------------------------------
  36 ---------------------------------------------------RQEAAGSRGRRAPR
  37 -----------------------------------------------------------------
  38 -----------------------------------------------------------------
  39 ----------------------------------------------CGKYTEKHTCERCGRRTEE
  40 -----------------------------------------------------------------
  41 ------------------------------------------------DKHSKPRGGKGRGKSGG
  42 -----------------------------------------------SNNSGTPATKSSSKPTKK
  43 --------VLRDNFNPAQPLHTLRPPQPPIMPNSGPSAEKRKE--------GGGKGGGKGGRGRE
  44 -----------------------------------------------------------------
  45 ---------------------------------------------ICKRCGEFEGSCECGK-GEV
  46 -----------------------------------------------------------------
  47 -----------------------------------------------------------------
  48 -----------------------------------------------------------------
  49 -------------------------------------------------GRGGRGPKSGGHGGGH
  50 -----------------------------------------------------------------
  51 -----------------------------------------------------------------
  52 -----------------------------------------------------------------
  53 -----------------------------------------------------------------
  54 ------------------------------ELSSQPKGDLTRDLAIRLRDAWAKRRGTPGDAPLR
  55 -----------------------------------------------------------------
  56 -----------------------------------------------------------------
  57 -----------------------------------------------------------------
  58 -----------------------------------------------------------------
  59 -----------------------------------------------------------------
  60 -----------------------------------------------------------------
  61 -----------------------------------------------------------------
  62 -----------------------------------------------------------------
  63 -----------------------------------------------------------------
  64 -----------------------------------------------------------------
  65 -----------------------------------------------------------------
  66 ---------------------------------------------------VNKNRKSRDENAMA
  67 -----------------------------------------------------KNRKSRDENAMA
  68 -----------------------------------------------------------------


         70        80         90         100       110            120  
         |         |          |           |         |              |  
   1 VLPGGMRVRLSKTLAGILRHH.PGRYGVRLTREGW..ARVSEVVEGLRK.....AGWSWVEEWHI
   2 VLPGGMRVRLSKTLAGILRHH.PGRYGVRLTREGW..ARVSEVVEGLRK.....AGWSWVEEWHI
   3 VLPGGMRVRLSKTLAGILRHH.PGRYGVRLTREGW..ARVSEVVEGLRK.....AGWSWVEEWHI
   4 LMNEREVDEVSRTLAAILRHD.PERYHIRLDSHGY..ARIAGIVTVLRKy....KGMKWITFDHI
   5 LLDDNKEEKLGRFVSGTLRHF.PESAGVTMDRFGW..VNINDFCDVMRK.....RY-SWMRKEYL
   6 MMNEAEINEVSRTLAAVLRHD.PGRYGIRLDSHGY..ARISSLVSMFRKr....KGMRWMTDDHL
   7 ---GDRRFKVSKLMAYILRHS.PWEFGLEPDEEGF..VELADLIRAIKT.....VY-PWVTEEFI
   8 VLDDSREEKLGRFVSGTLRHF.PASAGVKMDEYGW..VDLNAFCDVMKK.....RY-NWMRKEYL
   9 QMKQRELIRISKFLSLVLRHR.PEQIGLSLDQHGW..AEVDELIRCANR.....HGLP-LSRAQL
  10 VLDDGREEKLGRFVSGTLRHF.PASAGVKMDKYGW..IDLNAFCEVMKK.....RY-NWMRKEYL
  11 -------FKVSKLMAYILRHS.PWEFGLEPDEEGF..VSIEELVNAVRK.....VY-PWVTEEYI
  12 ILDGAMRLKISKLLSLALRHS.PSVLGLSLDKGGW..ADVKTALEGLRK.....AGIR-ADYEAL
  13 ---DSRLVKISKYLSKYLRHT.PDAIGIKLAPGGW..VAVDELITACAK.....NKFP-ITRQEL
  14 KYNEKELADTSKFLSFVLRHK.PEAIGIVLDREGW..ADINKLILCAQK.....AGKR-LTRALL
  15 ------QDDHSRFLSLVLRHQ.PETIGLQLDDQGW..ADIGELLARLAA.....KGRN-LGRKQL
  16 -------VKLGRFISLILRHK.PETINLKLDKNGW..ANTKELIEKISK.....SGRE-IDFEIL
  17 ILPKEKVEKLGKFISGVLRHF.PDKFGLNMDENGW..VNLESLARVVKR.....RY-KWANIWLI
  18 KYNEKELADTSKFLSFVLRHK.PEAIGIVLDREGW..ADINKLILCAQK.....AGKR-LTRALL
  19 --------KLGRFISLILRHK.PETIDLKLDKNGW..ANTKELIEKISK.....SGRE-IDFEIL
  20 ----ERTVKVSKYLSKHLRHQ.PERIGLTPDEGGW..VEIDALVAAAAA.....HGFP-FTRQEL
  21 KYNEKELADTSKFLSFVLRHK.PEAIGIVLDREGW..ADIDKLILCAQK.....AGKR-LTRALL
  22 --------KISKYISLILRHK.PEEIGLKLDEHGY..LGVLDLIEGLNK.....SYKG-FSMDDL
  23 ------RFKVSKLMAYILRHD.PWSFNLQPDEEGF..VDLEEFVNAIRR.....VY-PWVTKEFI
  24 ---KKQRDEISKLLSYVLRHA.PESMGLTLDRDGW..CEVDELVGKANA.....NGHS-FDRQAL
  25 RGDEDGDVRLSKSLSYALRHG.ANQMGLQIGSDGF..VFVEELLAHPQF.....RS---YSLEDV
  26 GGGKDRIDALGRLLTRILRHM.ATELRLNMRGDGF..VKVEDLLNLNLKtsan.IQLKSHTIDEI
  27 ---------TSKFLSYVLRHA.PESIGLVLDSQGW..ADVADLLAKANA.....SGTP-LDEAGL
  28 -----DATRISRTLSYLLRHA.PQTIGLQLDPEGW..ADIDELIAGIAR.....QGLH-LDRATL
  29 --------------AYILRHS.PWEFGLEPDEEGF..VELADLIRAIKT.....VY-PWVTEEFI
  30 ----KTLDDTSKFLSYVLRHQ.PEAIGLTLDGEGW..ADIDALIAGAAR.....DGRA-LDRMLL
  31 ----KTLDDTSKFLSYVLRHQ.PEAIGLTLDGEGW..ADIDALIAGAAR.....DGRA-LDRMLL
  32 -----QLIKISRFLSYHLRHA.PEKLGLELEPGGW..ISTEKLLKACQN.....TKFT-LTFSDL
  33 ---EREVDEVSRTLAAILRHD.PERYHIRLDSHGY..ARIAGIVTVLRKy....KGMKWITFDHI
  34 --------KLSKEVAYALRHA.PWEYGLELDAEGW..VDINQLLSSLHEc....EKWKKVSEHDL
  35 ----KQLVSTSKFLSLVLRHQ.PGVIGMTLDEQGW..LEIDGLIANANT.....RGKK-LTLELI
  36 PREQDRDVQLSKALSYALRHG.ALKLGLPMGADGF..VPLGTLLQLPQF.....RG---FSAEDV
  37 --NEKELADTSKFLSFVLRHK.PEAIGIVLDREGW..ADIDKLILCAQK.....AGKR-LTRALL
  38 -------TDISKFLSYILRHQ.PEAIGLSLDKEGW..VVISDLILCAAE.....EGYI-FDNNLI
  39 FLDGRRRLALSKLLSGILRHF.PEEVKVKLDDEGFtdCDVHELAERIKKywknrEYYRWLTGEHI
  40 -----FYTNLSKEVSYALRHA.QWKYELELDENGW..VSVEQLLHALHQs....IEWRDVKIEDL
  41 GGGHGREVQVSKALSRLLRHQ.AANAGIQLDDEGF..ARLDTVLAWNPL.....RSLK-VTFDDV
  42 IRPRNDLVHYSKALSKVLRHT.AKANGLQIREDGY..IEVDSILKLPQF.....RG---MGMELL
  43 RKPPSREVTVSKALSLLLRHA.AEREGLKIDSQGY..ANVADVLAWRKL.....KSLK-VTFPEI
  44 -------DALGRILTRILRHM.ATELRLNMRGDGF..VKVEDLLNLNLKtcan.IQLNSHTIDEI
  45 LLKSEDRKKVSKFLSGLLRHF.GRDFGVRLDEDGW..AELRDVLKILSE.....RY--GVGRKHV
  46 ----KRDIAISKSLSYLLRHG.AVKEKLNIDQTGY..ININELLNHNRL.....KTNK-VTLDDI
  47 ----KEQIRISKFLSLVLRHQ.PELIGLQLNEQGW..AHIETLLEKSAA.....YGVS-FDKQTL
  48 ------NTQLSKKLSWLLRHG.AKTEGITIRADGF..VSVPDLQKHPRY.....LC---FTLEKL
  49 RKGGGRDVDLSRALSRLLRHQ.AASAGITLDAEGY..APLDKVLAWGPI.....RSLK-PTFPEI
  50 -----RDVLISKALSYLLRHG.AEKEKLSIDDQGY..VKISDVLSHQRL.....KSLK-TTRDDI
  51 --KDKRDVQLSKALSYLLRHT.AVKEKLTIDSNGY..TPLKELLSHNRL.....KTHK-CTVDDI
  52 ----RRDVLISKSLSYLLRHG.ALKEQLPIDSDGY..VPVSAVLAHNRL.....KSHR-CSFSDL
  53 --------EYSRKLSYILRHG.ATKEKLPIREDGY..LSVGVLLNRAGI.....KG-K-WNLEDT
  54 ELKDGRRRRISRSLSYHLRHG.RE---LTQNPQGW..VPIDSLVRALDP.....KL--RVSADEL
  55 ----KRDIQISKALSYLLRHG.AVKENLPFDVNGY..IEVERVLNHQRL.....KSHK-CTLEDL
  56 ----NAETQISKSMCYLLRHD.KN---FVKRSDGF..VSIDTLAEKLN-.....-----IDKQRI
  57 ---------------------.---------ADGF..VPLGTLLQLPQF.....RG---FSAEDV
  58 ---------------------.---------ADGF..VPLQALLQLPQF.....HS---FSIEDV
  59 ---------------------.-----------GF..VPLQALLQLPQF.....HS---FSIEDV
  60 ---EDPDVRNSKTLAYILRHG.AEKEGLYIRSDGF..IKLADVLARPKL.....KG---VDEPTI
  61 ------MFTISKKMSYLLRHD.PQ--NLNMDIEGF..VNVQDMLKKLE-.....-----ISLQML
  62 ---------------------.-------------..------CDIMDR.....RY-KWATRERL
  63 ---------ISKKLTWLLRHGdPAKTGLNMRNDGY..VEVNEILKQTC-.....-----ISLEKL
  64 ---------------------.-------------..------------.....-----------
  65 ---------------------.-------------..------------.....-----------
  66 KYNEKELADTSKFLSFVLRHK.PEAIGIVLDREGW..ANIDKLILCAQK.....AGKR-LTRALL
  67 KYNEKELADTSKFLSFVLRHK.PEAIGIVLDREGW..ANIDKLILCAQK.....AGKR-LTRALL
  68 ---------------------.-------------..------------.....-----------


           130            140            150                    160    
            |              |              |                      |    
   1 VGVALHDPKGRYELRNG.....E.....IRARYGHSIP...V.....NVEPLP.....GEPPPIL
   2 VGVALHDPKGRYELRNG.....E.....IRARYGHSIP...V.....NVEPLP.....GEPPPIL
   3 VGVALHDPKGRYELRNG.....E.....IRARYGHSIP...V.....NVEPLP.....GEPPPIL
   4 LSLAETDPKGRYQVSGV.....L.....IRAMYGHTIP...V.....DLSDLPe....DNIPDVL
   5 YALVESDEKGRYEIRNS.....R.....IRARYGHSVN...I.....DLDYRE.....SDSP-YL
   6 VYLAETDPRKRYQISGV.....L.....IRAVYGHTID...V.....DLTDLPt....DGIPDTL
   7 KEIVEKDSKGRYEIRGS.....K.....IRARYGHSYP...V.....VLKHEE.....DTESKVL
   8 YALVESDEKGRYQIRGF.....M.....IRARYGHSVN...I.....ELDYEE.....SDAP-YV
   9 EQVVAENDKQRFAFSADgr...R.....IRANQGHSLP...V.....DLQLTP.....AQPPPVL
  10 YALVESDEKGRYQISGP.....M.....IRARYGHSVN...V.....DLDYDE.....SDTP-YV
  11 REIVERDEKGRYEIRGN.....K.....IRARYGHSYP...V.....ILRHEE.....DKESKVL
  12 YAVVALDEKGRFELKDG.....K.....IRARYGHTID...V.....EVEYEA.....DSESKVL
  13 EAVVESSEKQRFSFDSTgt...L.....IRANQGHSVE...V.....DLQLEP.....VVPPDEL
  14 DTVVATSDKKRFSYSSDgr...C.....IRAVQGHSTSq..V.....AISFAE.....KTPPQFL
  15 EKIVLDNDKQRFAISEDgl...R.....IRANQGHSIK...I.....DLGLAA.....CEPPDRL
  16 ERIVNENNKKRYSFNEDkt...K.....IRAVQGHSIE...V.....NLELKE.....VVPPAIL
  17 KALVYSDEKQRYELKGD.....K.....IRARYGHSID...V.....KLSDFP.....EAKEDVL
  18 DTVVATSDKKRFSYSSDgr...C.....IRAVQGHSTSq..V.....AISFAE.....KTPPQFL
  19 ERIVNENNKKRYSFNEDkt...K.....IRAVQGHSID...V.....NLELKE.....IVPPAIL
  20 DHVVATNDKRRFAVEGT.....R.....IRASQGHSIA...V.....DLRLPV.....ATPPPYL
  21 DTVVATSDKKRFSYSSDgr...C.....IRAVQGHSTSq..V.....AISFAE.....KTPPQFL
  22 ERIVREDSKGRYSFNEDks...K.....IRANQGHSIK...V.....DLGLEA.....IKPPKVL
  23 LDIVERDEKERYEVKEG.....K.....IRARYGHSYP...V.....ILDHKE.....DKESKTL
  24 EEVVETNEKKRFTLSEDgq...R.....IRAAQGHSTEq..V.....QVQHIE.....KEPPAWL
  25 ERVVNTNDKQRFKLRSHre6clQ.....IRASQGHSIK...Vi....DLELKPvlagsPECPAEA
  26 REAVRRDNKQRFSLIDEngel.L.....IRANQGHSIT...Tve6klLKPILS.....PEEAPVC
  27 RAVVAESDKKRFTLSEDgr...R.....IRAAQGHSVK...V.....DLGQPP.....VEPPPQL
  28 ETVCATNDKQRFALSDDgr...R.....IRAVQGHSTP...Vv....QRRYPA.....AQPPERL
  29 KEIVEKDSKGRYEIRGS.....K.....IRARYGHSYP...V.....VLKHEE.....DTESKVL
  30 GAVVENNDKKRFALSADgq...R.....IRAVQGHSHAa..V.....AIAYAP.....AVPPAVL
  31 GAVVENNDKKRFALSADgq...R.....IRAVQGHSHAa..V.....AIAYAP.....AVPPAVL
  32 ETVVKDNDKQRFSFNEAkt...K.....IRANQGHSVN...I.....DLQLEP.....LIPPVIL
  33 LSLAETDPKGRYQVSGV.....L.....IRAMYGHTIP...V.....DLSDLPe....DNIPDVL
  34 HVMIEKSDKKRYEISNG.....K.....IRALYGHSIP...Q.....RIIKEQ.....KCPPEVL
  35 HEVVATNDKKRFVLSDDgl...R.....IRASQGHSVAg..V.....DLNLTE.....ANPPATL
  36 QRVVDTNRKQRFALQLGdp6glL.....IRANQGHSLQ...VpklelMPLETP.....QALPPML
  37 DTVVATSDKKRFSYSSDgr...C.....IRAVQGHSTSq..V.....AISFAE.....KTPPQFL
  38 HSIVNNSDKKRFTISDDgl...R.....IRAAQGHSTQq..V.....DIRYEA.....KIPPEFL
  39 IAVVETCPKGRFEIDEHg....R.....IRARYGHSRRls.V.....RPTLPE.....AENVKEL
  40 KIMIEKSEKKRHELKEN.....K.....IRALYGHSIP...M.....KIVKEE.....GVPPEFL
  41 QTAVSTDGKQRFTLKPNp17dyL.....IRANQGHSIK...Les7ltPVTVEA.....GNVPNRV
  42 LSIVKGNDKKRFTMEEVegvl.Y.....IRANQGHSIK...Avqvp.MARIDN.....ASSIPKV
  43 ISAVETSDKKRFALLYQ.....Pp51ylIRATQGHSIK...Tv10erLTLDNP.....DKLPETV
  44 REAVTRDNKKRFSLIDEdgel.L.....IRANQGHSIT...Tve6klLKPILS.....PEEAPVC
  45 ELIVKFDPKGRFELKNG.....R.....IRAKYGHSVE...V.....RTDWSEg....GEIPEKL
  46 RRIVGNNDKKRFSIVEKegei.M.....ICANQGHSIK...TvndsnLIQLSK.....DTIPEEI
  47 KYLVATNSKKRFAFSPDae...Y.....VRASQGHSVD...I.....ELGYKN.....QKPPEIL
  48 KEIAAADAKQRYTLRWNpe6vhE.....IRANQGHSLA...Vle7ggLENITH.....VSQVPLA
  49 LKAVKESDKQRFAIKLAp17dwL.....IRANQGHSIK...Le30teGEDGGT.....IPIPETV
  50 NRIVQENDKKRFTIKDD.....M.....ICANQGHSLK...Avk6nlTPMTVD.....ELNQLRI
  51 HRIVKENDKQRFHIKTLgadeeW.....ICATQGHSIK...Siq8vlVPITEA.....SQLPQEL
  52 QRIVENNEKKRFHMRPGpdgqeY.....ICATQGHTIE...Qvl8vlTQLIDP.....GELPAQL
  53 KRVVRDNDKQRYKLIFEp18gyW.....IRANQGHTIN...TkvemkALKTPE.....DFPTLEI
  54 ISVARAVSEERFEVRGD.....L.....VRARYGHSRP...T.....AIEYEI.....RAPEGRL
  55 HRVVDTNDKKRFNIKLSdd6teL.....ICAVQGHSID...Rik8vlEVIDTA.....EKLPKNI
  56 TEIAHKDSKNRYEINNS.....M.....IRAVQGHSNP...Hvif..QMEKVN.....IDYDGIA
  57 QRVVDTNRKQRFALQLGdp6glL.....IRANQGHSLQ...VpklelMPLETP.....QALPPML
  58 QLVVNTNEKQRFTLQPGep6glL.....IRANQGHSLQ...VpelelTPLETP.....QALPLTL
  59 QLVVDTNEKQRFTLQPGep6gpL.....IRANQGHSLQ...Vg11elMPLETP.....QALPSTL
  60 LHLVQTNAKKRFELFWG.....Yd131fIRATQGHSIQ...Les9qvKDDEEG.....KRKVGLM
  61 NKIVDTDNKQRYEIVND.....K.....IRAVQGHSIKnvnV.....SMPKVE.....ISYNGNA
  62 ISLIESDLKTRYEIKGS.....K.....IRARYGHSVN...V.....ELDYLE.....TELP-YL
  63 HYIVENDPKGRFRIIDEngkn.L.....IRANQGHSLS...Fi10rfEIDNNS.....EFIQRII
  64 -----------------.....-.....----------...V.....DLQLQP.....QLPPPIL
  65 -----------------.....-.....----------...-.....----AP.....AVPPAVL
  66 DTVVATSDK--------.....-.....----------...-.....------.....-------
  67 DTVVATSDK--------.....-.....----------...-.....------.....-------
  68 -----------------.....-.....----------...-.....------.....-------


         170       180         190               200       210        2
          |         |           |                 |         |         
   1 YHGTTEEALPLIMERG..IMRGRRLKVHLTS.....SL...EDAVSTGRRHGNLVAVLLVDV.EC
   2 YHGTTEEALPLIMERG..IMRGRRLKVHLTS.....SL...EDAVSTGRRHGNLVAVLLVDV.EC
   3 YHGTTEEALPLIMERG..IMRGRRLKVHLTS.....SL...EDAVSTGRRHGNLVAVLLVDV.EC
   4 YYQSSAAEAPLVKEAG..IYPSDKTWVHLSG.....TY...RRSYVSGLYHIDDPFILRIDA.RS
   5 YYGASPEEVDVLLENG..IFPIKQRYVHLST.....SY...EKAVEVALIHTENPVILQIDA.FK
   6 YYQSSTAEAPLVKEAG..IYPSDKSWIHLSG.....TY...RKSFVSGLYHIDDPLVLAVNA.RS
   7 YHGTIRENLKGILKEG..IKPMKRQYVHLSL.....SY...EDAYYTGRRHGKDVVVLLIDA.EC
   8 YYGASPEEVDVLLENG..IFPIKQRYVHLST.....SY...EKAAEVALIHTESPVILQVDA.FR
   9 YHGTAERFVESIKRDG..LLPGKRQYVHLSQ.....DE...TTALTVGQRHGR-PVVLTVHA.AA
  10 YYGASPEEVDVLLENG..IFPIKQRYVHLST.....TY...EKAAEVALIHTESPVILQVDA.FR
  11 YHGTVRRNLKGIMREG..IKPMKRQYVHLSI.....NY...EDAYNTGRRHGEDVVVLIIDA.EC
  12 YHGTSRHLLPSIMAQG..LLPMRRRYVHLSP.....DF...ATACQNARRRPL-PVVIEIDA.EC
  13 YHGTGHKSVDSIMETG..LCKMSRHHVHLSK.....DI...ATAQTVGARHGK-PVVFAISA.AA
  14 YHGTASRFLDEIKKQG..LIAGDRHYVHLSA.....DE...ATARKVGARHGS-PVVLTVKA.QE
  15 YHGTASRFLDAILAEG..LRPGQRQHVHLSA.....DG...QTARKVGARHGK-PVVLEIDA.RA
  16 YHGTAFKTLESIKKEG..IKKMSRQHVHLSA.....DI...ETAKNVATRHSGKYIILEIDT.EA
  17 YYGTSEEEAHRMLEIG..IKPVNQRYVHLST.....TI...EKSKEVASIRTDTPIVLEIDA.KK
  18 YHGTASRFLDEIKKQG..LIAGDRHYVHLSA.....DE...ATARKVGARHGS-PVVLTVKA.QE
  19 YHGTAFKNLESIKKEG..IIKMSRQYVHLSA.....DV...ETAKNVATRHSGKYIILEIDT.EA
  20 YHGTVARHLEAIRAEG..LRPMNRHDVHLSP.....DR...ETATRVGARRGR-PVVLPVDA.AT
  21 YHGTASRFLDEIKKQG..LIAGERHYVHLSA.....DE...ATARKVGARHGS-PVILTVKA.QE
  22 YHGTGRKYIESILKNG..LIKKERQYVHLSK.....DI...ETASIVGKRHGD-LVILEVDS.ES
  23 YHGTIRENLEGIMREG..IKPMKRQFVHLSL.....NY...EDAYNTGRRHGSNVVVLMIDA.DC
  24 YHGTASRFMASIETQG..LIAGSRHHVHLTE.....DP...ETALSVGKRYGQ-PVLLAVDA.KG
  25 VHGSYLRNWGSIKQQG..LSRMNRTHIHLAP.....GLp..GEDGVISGMRKDCDLAVFVDV.PK
  26 VHGTYRKNLESILASG..LKRMNRMHVHFSC.....GLp..TDGEVISGMRRNVNVIIFLDI.KK
  27 FHGTATRFLEPILREG..LRPGERQQVHLSA.....DR...TTALAVGQRHGK-PVVLIVDA.GQ
  28 YHGTATRFLDSIRAQG..LKPGARHHVHLSP.....DI...RTALAVGTRYGV-PVILEVDA.QR
  29 YHGTIRENLKGILKEG..IKPMKRQYVHLSL.....SY...EDAYYTGRRHGKDVVVLLIDA.EC
  30 YHGTASRFLDSIRERG..LVPGSRHHVHLSA.....RR...ATALEVGRRYGS-PVLLEIDA.RD
  31 YHGTASRFLDSIRERG..LVPGSRHHVHLSA.....RR...ATALEVGRRYGS-PVLLEIDA.RD
  32 YHGTHQKVVKTILKEG..LKKMARHHVHLSE.....RK...ETALKVGSRRGK-PVIFVIKA.QQ
  33 YYQSSAAEAPLVKEAG..IYPSDKTWVHLSG.....TY...RRSYVSGLYHIDDPFILRIDA.RS
  34 YHGTARRFVKSIKEKG..LQPQGRQYVHLSA.....DV...ETALQVGKRRDIKPVLLIVNA.LE
  35 YHGTVDAFLPRIREQG..LQKRSRNHVHLSA.....DE...ATATNVGSRRGK-PKLLLIAA.QR
  36 VHGTFWKHWPSILLKG..LSCQGRTHIHLAP.....GLp..GDPGIISGMRSRCEIAVFIDG.PL
  37 YHGTASRFLDEIKKQG..LIAGERHYVHLSA.....DE...ATARKVGARHGS-PVILTVKA.QE
  38 YHGTATRFIISIRVQG..LNAKDRQYVHLSA.....DE...ETAIQVGSRHGK-PIVLRIKA.LT
  39 YHGTARENLESILQHG..IKPMGRRAVHLTD.....DE...REALITALRHTRNPVILVVDA.ER
  40 YHGTSPRFLNSIESNG..LSPMSRQYVHLSE.....DI...ITAELVGKRKDKHPIILEVNT.GK
  41 LHGSFFYFWSAIVETGg.LKPMNRNHVHCSA.....GT...PEEGILSGMRRDAELIIEIDM.EE
  42 VHGTKKELWPVISKQG..LSRMKRNHIHCAT.....GLy..GDPGVISGIRKSCTLYIYIDS.AK
  43 VHGTYHSTWPLILESGg.VKCMGRNHAHFATg28sgAG...SHGMVISGMRADAAVLIYIDI.RR
  44 VHGTYRKNLESILASG..LKRMNRMHVHFSC.....GLp..TDGEVISGVRRNVNVIIFLHI.KK
  45 YHATSPENLNSILKTG..LLPMRRREVHMCS.....SP...QEAIEVGKRHSSNPVLLEIDA.KG
  46 YHGTYKNKLPAIFNSGg.LSKMNRNHIHFAS.....SI...SD---VSGIRNSSNVLIYLNI.EK
  47 YHGTAEKFMQSILETG..LEKCRRQHVHLSS.....TI...ETAIHVGQRHGK-PVVFTVLA.QQ
  48 VHGTYYRHWGAIRSQG..LSRMNRNHVHFAC.....SD...ETNSTLSGFRSDCQILIYLNV.EK
  49 VHGTYFAFWDKIIQSGg.LKPMGRNHVHFST.....GLpedTERGVISGMRSDAEVLVFVDV.ER
  50 YHGTYRTKLPLIKSSGg.LSKMNRNHIHFTC.....--...EQYSTCSGIRYNANVLIYINA.SK
  51 IHGTNLQSVIKIIESGa.ISPMSRNHVHLSP.....GMl..HAKGVISGMRSSSNVYIFIDChSP
  52 IHGTNLRNAVLILDSGc.IKRMQRNHVHLSH.....GVt..GKDCVISGMRLSSTVHIYLNT.EG
  53 FHATSKQVLPIVLKEG..LSKMKRQHIHLAT.....DLv..TEGGSVAGKRLNREVFIYINV.PK
  54 YHCTPTTALHNIFERGegLRPMTRQWVHLTT.....DR...AAALSAGRRHGPCTLLCVPDP.SA
  55 IHGTSVRNAIQILKSGs.IKRMNRNHIHLSI.....GIte.KDKEVISGMRKSSRVHIYILS.EP
  56 VHGTFKKHLNSIMLHG..LKRMSRNHIHLGT.....SK...KNA------RKNAEVFVYIDI.QK
  57 VHGTFWKHWPSILLKG..LSCQGRTHIHLAP.....GLp..GDPGIISGMRSHCEIAVFIDG.PL
  58 VHGTFWKHWPSILLKG..LSRQGRTHIHLAS.....GLp..GDPGVISGIRPNCEVAVFIDG.PL
  59 VHGTFWKHWPSILLNG..LSRQGRTHIHLAS.....GLp..GDSGVISGIRPNCEVAVFING.AL
  60 VHGTRWELWDTLKEQG..LQKMTRQHIHLAP.....GF...SGPIT---PRPNSTLYIYLDL.SK
  61 IHGTFSKNLPFILTEG..IKRFTRKHIHMAT.....DMk..-------FVRKNTNVFIYVNI.PK
  62 YYGVSQEEVDMLLDTG..IAPMRQRYVHLST.....SY...GKAIESASVHTENPVVLEVDV.DE
  63 IHGTYLDKWKNIKING..LSRMSRSHIHFVSa26vrEM...CNYKCTAGIRPNCEVLVFIDV.VN
  64 YHGTGEKSVPAILKSG..LLKMSRHHVHLSK.....DI...ETARTVGIRHGK-PVIFSVDA.MV
  65 YHGTASRFLDSIRERG..LVPGSRHHVHLSA.....RR...ATALEVGRRYGS-PVLLEIDA.RD
  66 ----------------..-------------.....--...---------------------.--
  67 ----------------..-------------.....--...---------------------.--
  68 ----------AIRREG..LRPVHRHHVSLSA.....DT...GAAQQVGARRGR-AVALVVAT.GA


      20            230            240       250      
      |              |              |         |      
   1 LRRR.....GLKVERMSKTVYTVDW.....VPPECIAEVRRESLGRSL
   2 LRRR.....GLKVERMSKTVYTVDW.....VPPECIAEVRRESLGRSL
   3 LRRR.....GLKVERMSKTVYTVDW.....VPPECIAEVRRESLGRSL
   4 MIDS.....GHDIYRSSDDIYLTRE.....IPPEYIQDAEPEE-----
   5 AQED.....GISLKLATDDIVLAER.....IPPEYLFVV---------
   6 MIEN.....GIDIFRSNDDIYLTKQ.....VPPEYITIAEK-------
   7 LRRK.....GYKILKAGKRVRIVKH.....VPVECISEI---------
   8 AQED.....GISLKLATDYIVLAEK.....IPPEYLYVI---------
   9 MTAA.....GYVFYVSANGVWLTKQ.....VPARFI------------
  10 AQED.....GISLKLATDYIVLAEK.....IPPDYLFV----------
  11 LRNK.....GYKILKAGKKVRIVKH.....VPVDCI------------
  12 LRAR.....GYVVYAASGKVRLAKH.....VPPECLKKVVD-------
  13 MHQA.....GYIFYCSDNGVWLVDR.....VPPEYLQ-----------
  14 MAKR.....GIPFWQAENGVWLTST.....VAVEFL------------
  15 MRQA.....GLAFYRSDNGVWLIDG.....VPPVFIR-----------
  16 MLKE.....NYKFYLSENKVWLTDF.....VPSKFI------------
  17 ARED.....GIRIIKANDLIALAEE.....IPAKYIK-----------
  18 MAKR.....GIPFWQAENGVWLTST.....VAVEFL------------
  19 MLKE.....NYKFYLSENKVWLTDF.....VPSRFI------------
  20 MHRD.....GHVFHVSANGVWLTQH.....VPSRYL------------
  21 MAKR.....GLPFWQAENGVWLTST.....VAVEFL------------
  22 MFKD.....GIKFYLSKNNVWLCDY.....VKVEYIKE----------
  23 LRKK.....GFKILKAGKKVRIVKY.....VPVDCI------------
  24 MFEA.....GVQFFQADNGVWLVEA.....VPIEWLTKV---------
  25 ALAD.....GLEFFWSENGVLLTAGntegmLPPKYFSRALRLKPTRSL
  26 ALED.....GIAFYISDNKVILTEGidgv.LPVDYFQKIESWPDRQSI
  27 MFAD.....GCRFYLADNGVWLTDA.....VPFSYLT-----------
  28 MHRQ.....GHTFFVAENGVWLTDT.....VPAEFLKE----------
  29 LRRK.....GYKILKAGKRVRIVKH.....VPVECISEI---------
  30 MHLA.....GHLFHQAENGVWLTER.....VPVRFIR-----------
  31 MHLA.....GHLFHQAENGVWLTER.....VPVRFIR-----------
  32 MSED.....GCIFYCSDNGVWLVDY.....IDPKYL------------
  33 MIDS.....GHDIYRSSDDIYLTRE.....IPPEYIQDAEPEE-----
  34 AWSE.....GIKFYLGNDKVWLADA.....IPSKYI------------
  35 MHQD.....GHIFYLSENEVWLVDS.....VPPTYL------------
  36 ALAD.....GIPFFRSANGVILTPGntdgfLLPKYFKEALQLRP----
  37 MAKR.....GLPFWQAENGVWLTST.....VAVEFL------------
  38 MYEQ.....GFYFYQAANGVWLSNS.....IPYQFI------------
  39 LRRH.....GLVPRKAGKNVYVVEGt....VPPDCITRVIR-------
  40 AREE.....GVKFYLGNEKVWLADE.....IPSEFI------------
  41 SLKD.....GIKWWLSDNGVLLTEGdeqgiLSTKYFKLVTGRNIDV--
  42 AMQD.....GVEFYRSENGVILTEGvngl.LSSKYFSRVET-------
  43 ALAG.....GCPFWRSENGVILSEGm15gvIPVEYFDVVVERR-----
  44 ALED.....GIAFYISDNKVILTQGivgv.LPVDYFQKIESWPDRQSI
  45 LMQD.....GIEVRR-KGKVYTVDF.....VPPKFIR-----------
  46 CLQS.....GIVFYRSSNNVILTSGdanglIGLEFFGKVVDAKNGTP-
  47 MYAN.....DFSFYLSDNGVWLTDH.....VPVIYL------------
  48 VLAD.....GIPIYRSSNNVLLCPGiegf.IHSSYFQRVVDKKTGQPL
  49 SIRDa12gkGIKWWMSDNGVVLTEGdkdglVPLKYFKEVRGRRQGVG-
  50 CIEH.....GIVFYKSLNNVILTSGdkdgkLSWEFIDRIVGL------
  51 LFFQ.....TLKMFRSLNNVYLSSS.....IPVELIQKV---------
  52 IL-D.....HLRLYKSRNDVYLTPSd....IPVSMFKKV---------
  53 ALEA.....GIEFFLSENGVVLTEGkdgk.ISREFFSKILD-------
  54 ----.....-LECRHAGGATWLVAQ.....VPPSALTV----------
  55 KILE.....HLKLYRSMNSVILTPD.....------------------
  56 CLKN.....GILFHFSSNGYILTTGidgt.IPSKYISK----------
  57 ALAD.....GIPFFRSANGVILTPGntdgfLLPKYFKEALQLRP----
  58 ALTD.....GIPFFCSANGVILTPGnaegfLLPKYFKEALQLRP----
  59 ALTD.....GIPFFCSVNGVILTPGnadgfLLPKYFKEALQLRP----
  60 LVAA.....GIPVYVSANGVVLTPGs11agVGKEFWRRAVRRKE----
  61 CIED.....GIICYYSANN------.....------------------
  62 AQNN.....GLHFMLVNDDIVLTDG.....VPPEYLSVV---------
  63 CVTNsa...EYKFYLSDNGVVLTRGnsqgiID----------------
  64 MYQS.....GFTFYCSDNGVYLVDH.....VPPEYL------------
  65 MHLA.....GHLFHQAENGVWLTER.....VPVRFIR-----------
  66 ----.....----------------.....------------------
  67 ----.....----------------.....------------------
  68 LREA.....GYDFFRSDNGVWLTDT.....VPPEYLI-----------