We made conjectures about the disulfide bonds, and later confirmed them from the literature. We put in 8 disulfide constraints in all our models (except the initial fully automatic one): SSBond C150 C120 SSBond C178 C166 SSBond C205 C52 SSBond C312 C240 SSBond C321 C223 SSbond C346 C402 SSBond C390 C407 SSBond C392 C409 We had expected these strong constraints to make folding easy, but we were unable to get a really compact structure. This is try7-opt2, built before we split the target into domains. It is not as compact as our model 2, but it does not suffer as badly from large breaks as many of our earlier attempts.