a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0222 spsE, Bacillus subtilis
- gi|12056473|ref|NP_061819.2|_6:358 N-acetylneuraminic acid phosphate synthase; sialic acid synthase; N-acetylneuraminic acid phosphate synthase; sialic acid synthase; sialic acid phosphate synthase [Homo sapiens]
- gi|20978759|sp|Q9NR45|SIAS_HUMAN Sialic acid synthase (N-acetylneuraminate synthase) (N-acetylneuraminic acid synthase) (N-acetylneuraminate-9-phosphate synthase) (N-acetylneuraminic acid phosphate synthase) [Taxonomy]
- gi|12652539|gb|AAH00008.1| N-acetylneuraminic acid phosphate synthase [Homo sapiens]
- gi|17939512|gb|AAH19315.1|_6:358 N-acetylneuraminic acid phosphate synthase [Homo sapiens]
- gi|7023053|dbj|BAA91818.1|_6:358 unnamed protein product [Homo sapiens]
- gi|8453156|gb|AAF75261.1|_6:358 N-acetylneuraminic acid phosphate synthase [Homo sapiens]
- gi|15669254|ref|NP_248059.1|_2:334 spore coat polysaccharide biosynthesis protein E [Methanocaldococcus jannaschii DSM 2661]
- gi|3123092|sp|Q58465|YA65_METJA Hypothetical protein MJ1065 [Taxonomy]
- gi|2129290|pir||H64432 spore coat polysaccharide biosynthesis protein E homolog - Methanococcus jannaschii [Taxonomy]
- gi|1591717|gb|AAB99068.1| spore coat polysaccharide biosynthesis protein E [Methanocaldococcus jannaschii DSM 2661]
- gi|27714479|ref|XP_216398.1|_6:357 similar to N-acetylneuraminic acid synthase (sialic acid synthase) [Rattus norvegicus]
- gi|16716467|ref|NP_444409.1|_6:357 N-acetylneuraminic acid synthase (sialic acid synthase); N-acetylneuraminic acid 9-phosphate synthetase; sialic acid synthase; N-acetylneuraminic acid phosphate synthase [Mus musculus]
- gi|13097042|gb|AAH03307.1| N-acetylneuraminic acid synthase (sialic acid synthase) [Mus musculus]
- gi|26345280|dbj|BAC36290.1| unnamed protein product [Mus musculus]
- gi|37046732|gb|AAH57977.1| N-acetylneuraminic acid synthase (sialic acid synthase) [Mus musculus]
- gi|11360372|pir||JC7321_6:357 N-acetylneuraminic acid 9-phosphate synthase (EC 4.1.3.-) - mouse [Taxonomy]
- gi|8978234|dbj|BAA98131.1| N-acetylneuraminic acid 9-phosphate synthetase [Mus musculus]
- gi|48859332|ref|ZP_00313268.1|_6:348 COG2089: Sialic acid synthase [Clostridium thermocellum ATCC 27405]
- gi|13876783|gb|AAK43615.1|_3:334 putative N-acetyl neuramic acid synthetase NeuB [Streptococcus agalactiae]
- gi|45592938|ref|NP_996660.1|_5:354 Unknown (protein for MGC:77126); wu:fb73c01 [Danio rerio]
- gi|41351113|gb|AAH65584.1| Unknown (protein for MGC:77126) [Danio rerio]
- gi|13022171|gb|AAK11670.1|_3:334 putative N-acetyl neuramic acid synthetase NeuB [Streptococcus agalactiae]
- gi|20560097|gb|AAM27839.1|_4:347 ORF_13; similar to NeuB family [Pseudomonas aeruginosa]
- gi|20560120|gb|AAM27859.1| ORF_13; similar to NeuB family [Pseudomonas aeruginosa]
- gi|25011285|ref|NP_735680.1|_3:335 Unknown [Streptococcus agalactiae NEM316]
- gi|3721923|dbj|BAA33753.1| neuB [Streptococcus agalactiae]
- gi|5381190|dbj|BAA82287.1| NeuB [Streptococcus agalactiae]
- gi|23095709|emb|CAD46895.1| Unknown [Streptococcus agalactiae NEM316]
- gi|22537319|ref|NP_688170.1|_3:335 N-acetyl neuramic acid synthetase NeuB [Streptococcus agalactiae 2603V/R]
- gi|11281338|pir||T44651 capsular polysaccharide biosynthesis protein cpsN [imported] - Streptococcus agalactiae [Taxonomy]
- gi|5823220|gb|AAD53074.1| NeuB [Streptococcus agalactiae]
- gi|13549139|gb|AAK29661.1| NeuB [Streptococcus agalactiae]
- gi|22534190|gb|AAN00043.1| N-acetyl neuramic acid synthetase NeuB [Streptococcus agalactiae 2603V/R]
- gi|16080838|ref|NP_391666.1|_4:371 alternate gene name: ipa-67d [Bacillus subtilis]
- gi|730814|sp|P39625|SPSE_BACSU Spore coat polysaccharide biosynthesis protein spsE [Taxonomy]
- gi|629074|pir||S39722 spore coat polysaccharide synthesis protein spsE - Bacillus subtilis [Taxonomy]
- gi|413991|emb|CAA51623.1| ipa-67d [Bacillus subtilis]
- gi|2636322|emb|CAB15813.1| spsE [Bacillus subtilis subsp. subtilis str. 168]
- gi|5616174|gb|AAD45660.1|_8:350 NeuB [Aeromonas punctata]
- gi|41725200|ref|ZP_00151958.1|_5:346 COG2089: Sialic acid synthase [Dechloromonas aromatica RCB]
- gi|48860247|ref|ZP_00314173.1|_3:327 COG2089: Sialic acid synthase [Clostridium thermocellum ATCC 27405]
- gi|12004283|gb|AAG43980.1|_2:345 sialic acid synthase [Campylobacter jejuni]
- gi|6969989|gb|AAF34144.1|_2:345 sialic acid synthase [Campylobacter jejuni]
- gi|40217907|gb|AAR82876.1| putative sialic acid synthase [Campylobacter jejuni]
- gi|15430484|gb|AAK96002.1|_2:345 putative sialic acid synthase [Campylobacter jejuni]
- gi|15824492|gb|AAL09369.1|_2:345 sialic acid synthase [Campylobacter jejuni]
- gi|15718490|gb|AAL05991.1|_2:345 sialic acid synthase [Campylobacter jejuni]
- gi|6940835|gb|AAF31772.1|_2:345 sialic acid synthase [Campylobacter jejuni]
- gi|12697602|dbj|BAB21605.1|_3:335 NeuB [Streptococcus agalactiae]
- gi|47682297|gb|AAH70693.1|_5:353 Unknown (protein for MGC:83164) [Xenopus laevis]
- gi|46142536|ref|ZP_00204328.1|_4:341 COG2089: Sialic acid synthase [Methanococcoides burtonii DSM 6242]
- gi|15193222|gb|AAK91726.1|_2:345 putative sialic acid synthase [Campylobacter jejuni]
- gi|15895456|ref|NP_348805.1|_4:348 Sialic acid synthase [Clostridium acetobutylicum ATCC 824]
- gi|25345168|pir||F97169 sialic acid synthase [imported] - Clostridium acetobutylicum [Taxonomy]
- gi|15025183|gb|AAK80145.1| Sialic acid synthase [Clostridium acetobutylicum ATCC 824]
- gi|15718505|gb|AAL06005.1|_2:345 sialic acid synthase [Campylobacter jejuni]
- gi|6523010|emb|CAB62155.1|_6:348 putative polysaccharide biosynthesis protein [Sinorhizobium meliloti]
- gi|46914306|emb|CAG21085.1|_2:344 putative polysaccharide biosynthesis protein, NeuB [Photobacterium profundum]
- gi|20560145|gb|AAM27877.1|_5:348 ORF_11; similar to NeuB family [Pseudomonas aeruginosa]
- gi|23127158|ref|ZP_00109033.1|_2:347 COG2089: Sialic acid synthase [Nostoc punctiforme]
- gi|46112649|ref|ZP_00181369.2|_5:336 COG2089: Sialic acid synthase [Moorella thermoacetica ATCC 39073]
- gi|47220009|emb|CAG11542.1|_5:346 unnamed protein product [Tetraodon nigroviridis]
- gi|31324516|gb|AAM76277.1|_5:332 PtmC [Campylobacter coli]
- gi|34558392|ref|NP_908207.1|_6:336 SIALIC ACID SYNTHASE [Wolinella succinogenes DSM 1740]
- gi|34484111|emb|CAE11107.1| SIALIC ACID SYNTHASE [Wolinella succinogenes]
- gi|48729590|ref|ZP_00263340.1|_3:347 COG2089: Sialic acid synthase [Pseudomonas fluorescens PfO-1]
- gi|15792640|ref|NP_282463.1|_8:342 N-acetylneuraminic acid synthetase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|11281336|pir||B81275 N-acetylneuraminic acid synthetase (EC 4.1.3.-) Cj1317 [imported] - Campylobacter jejuni (strain NCTC 11168) [Taxonomy]
- gi|6968751|emb|CAB73744.1| N-acetylneuraminic acid synthetase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|15559181|gb|AAK58485.1|_8:342 NeuB3 [Campylobacter jejuni]
- gi|23014357|ref|ZP_00054178.1|_2:346 COG2089: Sialic acid synthase [Magnetospirillum magnetotacticum]
- gi|31324511|gb|AAM76272.1|_8:342 NeuB3 [Campylobacter coli]
- gi|24214313|ref|NP_711794.1|_120:463 putative N-acetyl neuramic acid synthetase NeuB [Leptospira interrogans serovar Lai str. 56601]
- gi|24195236|gb|AAN48812.1| putative N-acetyl neuramic acid synthetase NeuB [Leptospira interrogans serovar lai str. 56601]
- gi|28211365|ref|NP_782309.1|_6:349 N-acetylneuraminate synthase [Clostridium tetani E88]
- gi|28203806|gb|AAO36246.1| N-acetylneuraminate synthase [Clostridium tetani E88]
- gi|45658018|ref|YP_002104.1|_120:463 sialic acid synthase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
- gi|45601259|gb|AAS70741.1| sialic acid synthase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
- gi|15676004|ref|NP_273132.1|_6:347 polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis MC58]
- gi|2120917|pir||S60760 polysialic acid capsule biosynthesis protein SiaC NMB0068 [imported] - Neisseria meningitidis (strain MC58 serogroup B) [Taxonomy]
- gi|520735|gb|AAA20477.1| siaC [Neisseria meningitidis]
- gi|530040|emb|CAA54984.1| synC [Neisseria meningitidis serogroup B]
- gi|1399040|gb|AAB17455.1| capsule biosynthesis protein [Taxonomy]
- gi|7225288|gb|AAF40535.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis MC58]
- gi|1091228|prf||2020421C CMP-NeuNAc synthetase [Taxonomy]
- gi|14517803|gb|AAK64368.1|_4:341 NnaB [Escherichia coli]
- gi|11095588|gb|AAG29923.1|_5:342 SiaC [Campylobacter jejuni]
- gi|11527839|gb|AAG37021.1| putative sialic acid synthase [Campylobacter jejuni]
- gi|15792466|ref|NP_282289.1|_5:342 N-acetylneuraminic acid synthetase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|11281335|pir||H81318 N-acetylneuraminic acid synthetase (EC 4.1.3.-) Cj1141 [imported] - Campylobacter jejuni (strain NCTC 11168) [Taxonomy]
- gi|6968575|emb|CAB73396.1| N-acetylneuraminic acid synthetase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|14993925|gb|AAK73184.1| sialic acid synthase [Campylobacter jejuni]
- gi|15150370|gb|AAK85420.1| sialic acid synthase [Campylobacter jejuni]
- gi|23473585|ref|ZP_00128881.1|_11:349 COG2089: Sialic acid synthase [Desulfovibrio desulfuricans G20]
- gi|23475934|ref|ZP_00131191.1| COG2089: Sialic acid synthase [Desulfovibrio desulfuricans G20]
- gi|39997068|ref|NP_953019.1|_3:348 polysaccharide biosynthesis protein, putative [Geobacter sulfurreducens PCA]
- gi|39983958|gb|AAR35346.1| polysaccharide biosynthesis protein, putative [Geobacter sulfurreducens PCA]
- gi|24214309|ref|NP_711790.1|_14:341 putative N-acetyl neuramic acid synthetase NeuB [Leptospira interrogans serovar Lai str. 56601]
- gi|45658022|ref|YP_002108.1| N-acetylneuraminate synthase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
- gi|24195230|gb|AAN48808.1| putative N-acetyl neuramic acid synthetase NeuB [Leptospira interrogans serovar lai str. 56601]
- gi|45601263|gb|AAS70745.1| N-acetylneuraminate synthase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
- gi|15792650|ref|NP_282473.1|_4:332 N-acetylneuraminic acid synthetase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|11281337|pir||D81276 N-acetylneuraminic acid synthetase (EC 4.1.3.-) Cj1327 [imported] - Campylobacter jejuni (strain NCTC 11168) [Taxonomy]
- gi|6968761|emb|CAB73754.1| N-acetylneuraminic acid synthetase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|48824071|ref|ZP_00285499.1|_6:333 COG2089: Sialic acid synthase [Enterococcus faecium]
- gi|48854590|ref|ZP_00308752.1|_2:346 COG2089: Sialic acid synthase [Cytophaga hutchinsonii]
- gi|33862379|ref|NP_893939.1|_8:351 N-acetylneuraminate synthase [Prochlorococcus marinus str. MIT 9313]
- gi|33640492|emb|CAE20281.1| N-acetylneuraminate synthase [Prochlorococcus marinus str. MIT 9313]
- gi|30249539|ref|NP_841609.1|_119:461 Type III antifreeze protein:CBS domain:NeuB family [Nitrosomonas europaea ATCC 19718]
- gi|30138902|emb|CAD85481.1| Type III antifreeze protein:CBS domain:NeuB family [Nitrosomonas europaea ATCC 19718]
- gi|46446898|ref|YP_008263.1|_5:348 putative sialic acid synthase [Parachlamydia sp. UWE25]
- gi|46400539|emb|CAF23988.1| putative sialic acid synthase [Parachlamydia sp. UWE25]
- gi|48833332|ref|ZP_00290352.1|_4:331 COG2089: Sialic acid synthase [Magnetococcus sp. MC-1]
- gi|27364257|ref|NP_759785.1|_4:331 Sialic acid synthase [Vibrio vulnificus CMCP6]
- gi|27360375|gb|AAO09312.1| Sialic acid synthase [Vibrio vulnificus CMCP6]
- gi|33864984|ref|NP_896543.1|_4:331 putative N-acetylneuraminic acid synthetase [Synechococcus sp. WH 8102]
- gi|33638668|emb|CAE06963.1| putative N-acetylneuraminic acid synthetase [Synechococcus sp. WH 8102]
- gi|16127100|ref|NP_421664.1|_12:354 neuB protein, putative [Caulobacter crescentus CB15]
- gi|25345166|pir||D87604 neuB protein, probable [imported] - Caulobacter crescentus [Taxonomy]
- gi|13424484|gb|AAK24832.1| neuB protein, putative [Caulobacter crescentus CB15]
- gi|15644807|ref|NP_206977.1|_4:336 spore coat polysaccharide biosynthesis protein E [Helicobacter pylori 26695]
- gi|7465379|pir||B64542 spore coat polysaccharide biosynthesis protein E - Helicobacter pylori (strain 26695) [Taxonomy]
- gi|2313267|gb|AAD07248.1| spore coat polysaccharide biosynthesis protein E [Helicobacter pylori 26695]
- gi|2125968|pir||I69836_4:343 neuB protein - Escherichia coli [Taxonomy]
- gi|454081|gb|AAC43302.1| neuB [Taxonomy]
- gi|1093227|prf||2103192B sialic acid synthase [Taxonomy]
- gi|15611236|ref|NP_222887.1|_5:336 sialic acid synthase [Helicobacter pylori J99]
- gi|7465362|pir||B71965 sialic acid synthase - Helicobacter pylori (strain J99) [Taxonomy]
- gi|4154681|gb|AAD05747.1| sialic acid synthase [Helicobacter pylori J99]
- gi|27381082|ref|NP_772611.1|_12:354 blr5971 [Bradyrhizobium japonicum USDA 110]
- gi|27354248|dbj|BAC51236.1| blr5971 [Bradyrhizobium japonicum USDA 110]
- gi|33864930|ref|NP_896489.1|_122:463 putative N-acetylneuraminic acid synthetase [Synechococcus sp. WH 8102]
- gi|33638614|emb|CAE06909.1| putative N-acetylneuraminic acid synthetase [Synechococcus sp. WH 8102]
- gi|6688603|emb|CAB65212.1|_3:333 N-acetylneuraminic acid condensing enzyme [Legionella pneumophila]
- gi|42523180|ref|NP_968560.1|_3:352 putative N-acetylneuraminic acid synthetase [Bdellovibrio bacteriovorus HD100]
- gi|39575385|emb|CAE79553.1| putative N-acetylneuraminic acid synthetase [Bdellovibrio bacteriovorus HD100]
- gi|32266407|ref|NP_860439.1|_8:347 sialic acid synthase [Helicobacter hepaticus ATCC 51449]
- gi|32262457|gb|AAP77505.1| sialic acid synthase [Helicobacter hepaticus ATCC 51449]
- gi|23016878|ref|ZP_00056630.1|_12:344 COG2089: Sialic acid synthase [Magnetospirillum magnetotacticum]
- gi|2894127|emb|CAA04331.1|_8:326 sialic acid synthase [Campylobacter jejuni]
- gi|34499486|ref|NP_903701.1|_4:356 N-acetylneuraminic acid synthase [Chromobacterium violaceum ATCC 12472]
- gi|34105336|gb|AAQ61691.1| N-acetylneuraminic acid synthase [Chromobacterium violaceum ATCC 12472]
- gi|21357081|ref|NP_650195.1|_14:368 CG5232-PA [Drosophila melanogaster]
- gi|15213695|gb|AAK92125.1| Neu5Ac synthase [Drosophila melanogaster]
- gi|23171104|gb|AAF54811.2| CG5232-PA [Drosophila melanogaster]
- gi|28896974|ref|NP_796579.1|_3:355 putative N-acetylneuraminic acid synthetase [Vibrio parahaemolyticus RIMD 2210633]
- gi|28805182|dbj|BAC58463.1| putative N-acetylneuraminic acid synthetase [Vibrio parahaemolyticus]
- gi|37678496|ref|NP_933105.1|_3:355 sialic acid synthase [Vibrio vulnificus YJ016]
- gi|37197236|dbj|BAC93076.1| sialic acid synthase [Vibrio vulnificus YJ016]
- gi|20559814|gb|AAM27589.1|_7:357 ORF_8; similar to NeuB family [Pseudomonas aeruginosa]
- gi|27381103|ref|NP_772632.1|_6:354 blr5992 [Bradyrhizobium japonicum USDA 110]
- gi|27354269|dbj|BAC51257.1| blr5992 [Bradyrhizobium japonicum USDA 110]
- gi|31209579|ref|XP_313756.1|_2:327 ENSANGP00000003869 [Anopheles gambiae]
- gi|30176827|gb|EAA09258.2| ENSANGP00000003869 [Anopheles gambiae str. PEST]
- gi|47565300|ref|ZP_00236342.1|_2:308 sialic acid synthase, putative [Bacillus cereus G9241]
- gi|47557654|gb|EAL15980.1| sialic acid synthase, putative [Bacillus cereus G9241]
- gi|19705005|ref|NP_602500.1|_3:349 N-acetylneuraminate synthase [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
- gi|19712913|gb|AAL93799.1| N-acetylneuraminate synthase [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
- gi|48834484|ref|ZP_00291495.1|_18:300 COG2089: Sialic acid synthase [Thermobifida fusca]
- gi|42526472|ref|NP_971570.1|_9:375 neuB family protein [Treponema denticola ATCC 35405]
- gi|41816665|gb|AAS11451.1| neuB family protein [Treponema denticola ATCC 35405]
- gi|48833985|ref|ZP_00291001.1|_162:505 COG2089: Sialic acid synthase [Magnetococcus sp. MC-1]
- gi|29829916|ref|NP_824550.1|_9:291 putative N-acetylneuraminic acid (Neu5Ac) synthase [Streptomyces avermitilis MA-4680]
- gi|29607025|dbj|BAC71085.1| putative N-acetylneuraminic acid (Neu5Ac) synthase [Streptomyces avermitilis MA-4680]
- gi|21223255|ref|NP_629034.1|_9:292 putative polysaccharide biosynthesis related protein [Streptomyces coelicolor A3(2)]
- gi|13162070|emb|CAC33046.1| putative polysaccharide biosynthesis related protein [Streptomyces coelicolor A3(2)]
- gi|29347124|ref|NP_810627.1|_4:344 sialic acid synthase (N-acetylneuraminate synthase) [Bacteroides thetaiotaomicron VPI-5482]
- gi|29339023|gb|AAO76821.1| sialic acid synthase (N-acetylneuraminate synthase) [Bacteroides thetaiotaomicron VPI-5482]
- gi|46578765|ref|YP_009573.1|_9:349 NeuB family protein [Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough]
- gi|46448177|gb|AAS94832.1| NeuB family protein [Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough]
- gi|23473275|ref|ZP_00128571.1|_4:336 COG2089: Sialic acid synthase [Desulfovibrio desulfuricans G20]
- gi|21673654|ref|NP_661719.1|_2:278 sialic acid synthase [Chlorobium tepidum TLS]
- gi|21646772|gb|AAM72061.1| sialic acid synthase [Chlorobium tepidum TLS]
- gi|46581411|ref|YP_012219.1|_13:350 NeuB family protein [Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough]
- gi|46450833|gb|AAS97479.1| NeuB family protein [Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough]
- gi|24215281|ref|NP_712762.1|_14:290 putative N-acetyl neuramic acid synthetase NeuB [Leptospira interrogans serovar Lai str. 56601]
- gi|45657277|ref|YP_001363.1| N-acetylneuraminate synthase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
- gi|24196375|gb|AAN49780.1| putative N-acetyl neuramic acid synthetase NeuB [Leptospira interrogans serovar lai str. 56601]
- gi|45600515|gb|AAS70000.1| N-acetylneuraminate synthase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
- gi|6688588|emb|CAB65197.1|_5:361 hypothetical protein [Legionella pneumophila]
- gi|15639551|ref|NP_219001.1|_3:375 spore coat polysaccharide biosynthesis protein (spsE) [Treponema pallidum subsp. pallidum str. Nichols]
- gi|7521432|pir||H71307 probable spore coat polysaccharide biosynthesis protein (spsE) - syphilis spirochete [Taxonomy]
- gi|3322857|gb|AAC65539.1| spore coat polysaccharide biosynthesis protein (spsE) [Treponema pallidum subsp. pallidum str. Nichols]
- gi|48845795|ref|ZP_00300067.1|_4:276 COG2089: Sialic acid synthase [Geobacter metallireducens GS-15]
- gi|23474392|ref|ZP_00129686.1|_66:339 COG2089: Sialic acid synthase [Desulfovibrio desulfuricans G20]
- gi|11095584|gb|AAG29920.1|_2:227 NeuB [Campylobacter jejuni]
- gi|24374772|ref|NP_718815.1|_4:281 polysaccharide biosynthesis related-protein [Shewanella oneidensis MR-1]
- gi|24349442|gb|AAN56259.1| polysaccharide biosynthesis related-protein [Shewanella oneidensis MR-1]
- gi|34499345|ref|NP_903560.1|_4:336 probable spore coat polysaccharide biosynthesis protein E [Chromobacterium violaceum ATCC 12472]
- gi|34105195|gb|AAQ61551.1| probable spore coat polysaccharide biosynthesis protein E [Chromobacterium violaceum ATCC 12472]
- gi|34762797|ref|ZP_00143784.1|_211:444 N-acetylneuraminate synthase; Sialic acid biosynthesis protein NeuD [Fusobacterium nucleatum subsp. vincentii ATCC 49256]
- gi|27887548|gb|EAA24631.1| N-acetylneuraminate synthase; Sialic acid biosynthesis protein NeuD [Fusobacterium nucleatum subsp. vincentii ATCC 49256]
- gi|20092565|ref|NP_618640.1|_5:282 N-acetylneuraminic acid phosphate synthase [Methanosarcina acetivorans str. C2A]
- gi|19917839|gb|AAM07120.1| N-acetylneuraminic acid phosphate synthase [Methanosarcina acetivorans str. C2A]
- gi|23113005|ref|ZP_00098420.1|_94:351 COG2876: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Desulfitobacterium hafniense]
- gi|20807493|ref|NP_622664.1|_82:334 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Thermoanaerobacter tengcongensis]
- gi|20516022|gb|AAM24268.1| 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Thermoanaerobacter tengcongensis MB4]
- gi|48846743|ref|ZP_00301003.1|_88:341 COG2876: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Geobacter metallireducens GS-15]
- gi|39998232|ref|NP_954183.1|_95:333 phospho-2-dehydro-3-deoxyheptonate aldolase [Geobacter sulfurreducens PCA]
- gi|39985178|gb|AAR36533.1| phospho-2-dehydro-3-deoxyheptonate aldolase [Geobacter sulfurreducens PCA]
- gi|21400841|ref|NP_656826.1|_106:350 DAHP_synth_1, DAHP synthetase I family [Bacillus anthracis A2012]
- gi|30262916|ref|NP_845293.1| chorismate mutase/phospho-2-dehydro-3-deoxyheptonate aldolase [Bacillus anthracis str. Ames]
- gi|47528252|ref|YP_019601.1| chorismate mutase/phospho-2-dehydro-3-deoxyheptonate aldolase [Bacillus anthracis str. Ames 0581]
- gi|30257549|gb|AAP26779.1| chorismate mutase/phospho-2-dehydro-3-deoxyheptonate aldolase [Bacillus anthracis str. Ames]
- gi|47503400|gb|AAT32076.1| chorismate mutase/phospho-2-dehydro-3-deoxyheptonate aldolase [Bacillus anthracis str. Ames 0581]
- gi|42782054|ref|NP_979301.1|_106:350 chorismate mutase/phospho-2-dehydro-3-deoxyheptonate aldolase [Bacillus cereus ATCC 10987]
- gi|47568771|ref|ZP_00239466.1| MW1680 [Bacillus cereus G9241]
- gi|42737978|gb|AAS41909.1| chorismate mutase/phospho-2-dehydro-3-deoxyheptonate aldolase [Bacillus cereus ATCC 10987]
- gi|47554551|gb|EAL12907.1| MW1680 [Bacillus cereus G9241]
- gi|30021058|ref|NP_832689.1|_106:350 Chorismate mutase [Bacillus cereus ATCC 14579]
- gi|29896611|gb|AAP09890.1| Chorismate mutase [Bacillus cereus ATCC 14579]
- gi|39998422|ref|NP_954373.1|_59:311 phospho-2-dehydro-3-deoxyheptonate aldolase [Geobacter sulfurreducens PCA]
- gi|39985369|gb|AAR36723.1| phospho-2-dehydro-3-deoxyheptonate aldolase [Geobacter sulfurreducens PCA]
- gi|27262284|gb|AAN87423.1|_142:394 unknown [Heliobacillus mobilis]
- gi|48844333|ref|ZP_00298650.1|_93:333 COG2876: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Geobacter metallireducens GS-15]
- gi|40713168|emb|CAE53368.1|_82:335 phospho-2-dehydro-3-deoxyheptonate aldolase, AroA type [Actinoplanes teichomyceticus]
- gi|23023759|ref|ZP_00062990.1|_77:325 COG2876: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293]
- gi|45580866|emb|CAG15026.1|_82:335 heptulosonate synthase [Actinoplanes teichomyceticus]
- gi|28211280|ref|NP_782224.1|_17:260 putative phospho-2-dehydro-3-deoxyheptonate aldolase [Clostridium tetani E88]
- gi|28203720|gb|AAO36161.1| putative phospho-2-dehydro-3-deoxyheptonate aldolase [Clostridium tetani E88]
- gi|15806024|ref|NP_294725.1|_118:365 phospho-2-dehydro-3-deoxyheptonate aldolase/chorismate mutase [Deinococcus radiodurans R1]
- gi|7473313|pir||A75449 phospho-2-dehydro-3-deoxyheptonate aldolase/chorismate mutase - Deinococcus radiodurans (strain R1) [Taxonomy]
- gi|6458729|gb|AAF10576.1| phospho-2-dehydro-3-deoxyheptonate aldolase/chorismate mutase [Deinococcus radiodurans]
- gi|48477411|ref|YP_023117.1|_14:251 phospho-2-dehydro-3-deoxyheptonate aldolase [Picrophilus torridus DSM 9790]
- gi|48430059|gb|AAT42924.1| phospho-2-dehydro-3-deoxyheptonate aldolase [Picrophilus torridus DSM 9790]
- gi|41689347|ref|ZP_00145881.1|_2:190 COG2089: Sialic acid synthase [Psychrobacter sp. 273-4]
- gi|27717843|ref|XP_234991.1|_59:232 similar to N-acetylneuraminic acid synthase (sialic acid synthase) [Rattus norvegicus]
- gi|18075737|emb|CAD11290.1|_4:123 sialic acid synthase [Helicobacter pylori]
- gi|18075741|emb|CAD11293.1|_3:121 sialic acid synthase [Helicobacter pylori]
- gi|18075745|emb|CAD11296.1| sialic acid synthase [Helicobacter pylori]
- gi|41689345|ref|ZP_00145879.1|_2:118 COG2089: Sialic acid synthase [Psychrobacter sp. 273-4]
- gi|34762796|ref|ZP_00143783.1|_4:111 N-acetylneuraminate synthase [Fusobacterium nucleatum subsp. vincentii ATCC 49256]
- gi|27887547|gb|EAA24630.1| N-acetylneuraminate synthase [Fusobacterium nucleatum subsp. vincentii ATCC 49256]

              10        20             30        40                  50
              |         |              |         |                   |
   1 MAAFQIANKTVGKDAPVFIIAEAGINHD.....GKLDQAFALIDAAAE.....AGADA.....VK
   2 ---ELCPGRWVGGQHPCFIIAEIGQNHQ.....GDLDVAKRMIRMAKE.....CGADC.....AK
   3 ---ELCPGRWVGGQHPCFIIAEIGQNHQ.....GDLDVAKRMIRMAKE.....CGADC.....AK
   4 ---ELCPGRWVGGQHPCFIIAEIGQNHQ.....GDLDVAKRMIRMAKE.....CGADC.....AK
   5 ---ELCPGRWVGGQHPCFIIAEIGQNHQ.....GDLDVAKRMIRMAKE.....CGADC.....AK
   6 -EKIKIGDRYVGKGEPTFIIAEGGLNHN.....GDIDIGKELVKEAKK.....CGADA.....IK
   7 ---ELCPGRWVGGQHPCFIIAEIGQNHQ.....GDLDVAKRMIRTAKE.....CGADC.....AK
   8 ---ELCPGRWVGGKHPCFIIAEIGQNHQ.....GDIDVAKRMIRTAKE.....CGADC.....AK
   9 ---ELCPGRWVGGKHPCFIIAEIGQNHQ.....GDIDVAKRMIRTAKE.....CGADC.....AK
  10 ---IKIGNREIGEGCPCYIIAEMSANHA.....GDLGKAIEIIHAAKE.....AGADC.....IK
  11 -----------------YIIAEIGCNHN.....GDINLAKKMVDVAVS.....CGVDA.....VK
  12 --FELCPGRMIGGNNPCFIIAEIGQNHQ.....GDIEIAKKMIKMAKD.....CGADC.....AK
  13 -----------------YIIAEIGCNHN.....GDINLAKKMVDVAVS.....CGVDA.....VK
  14 --VISIAGRAIGPDYPPYIIAEMSANHN.....GSLETAFRIIEAAKS.....CGADA.....LK
  15 -----------------YIIAEIGCNHN.....GDINLAKKMVDVAVS.....CGVDA.....VK
  16 -----------------YIIAEIGCNHN.....GDINLAKKMVDVAVS.....CGVDA.....VK
  17 ---FQIANKTVGKDAPVFIIAEAGINHD.....GKLDQAFALIDAAAE.....AGADA.....VK
  18 --FITINGRKIGPDYPPYIIAELSANHN.....GDINRAFAIMEEAKK.....AGADA.....IK
  19 -----IDGRRIGHDAPPFIIAELSANHN.....GSLERALQTIDAAKA.....CGADA.....IK
  20 ----------------VFVIAEAGINHN.....GELKLAKKLVDAAKD.....AGADC.....IK
  21 -KEIKIQNIIISEEKAPLVVPEIGINHN.....GSLELAKIMVDAAFS.....AGAKI.....IK
  22 -KEIKIQNIIISEEKAPLVVPEIGINHN.....GSLELAKIMVDAAFS.....AGAKI.....IK
  23 -KEIKIQNIIISEEKAPLVVPEIGINHN.....GSLELAKIMVDAAFS.....AGAKI.....IK
  24 -KEIKIQNIIISEEKAPLVVPEIGINHN.....GSLELAKIMVDAAFS.....AGAKI.....IK
  25 -KEIKIQNIIISEEKAPLVVPEIGINHN.....GSLELAKIMVDAAFS.....AGAKI.....IK
  26 -KEIKIQNIIISEEKAPLVVPEIGINHN.....GSLELAKIMVDAAFS.....TGAKI.....IK
  27 -----------------YIIAEIGCNHN.....GDINLAKKMVDVAVS.....CGVDA.....VK
  28 --FELCPGRKIGGDNPCFIIAEIGQNHQ.....GDIEIAKKMILMAKE.....CGADC.....AK
  29 ----------ISENAPVFIIAEAGVNHN.....GSIALAKQLIDVAAK.....SNADA.....VK
  30 -KEIKIQNIIISEEKAPLVVPEIGINHN.....GSLELAKIMVDAAFS.....AGAKI.....IK
  31 --VIDIGGKKIGEGQRTFIIAEMSANHN.....QDFDRAVEIIKAAKR.....SGADA.....IK
  32 -KEIKIQNIIISEEKAPLVVPEIGINHN.....GSLELAKIMVDAAFS.....AGAKI.....IK
  33 --VITIAGREIGSDFPPYVIAEMSANHN.....GRIETALSLIDRAKE.....AGADA.....VK
  34 -SFITIDGRKIGPEHPPYIIAELSANHN.....GDINRAFKIMEEAKK.....AGADA.....IK
  35 ---IVIAGREIGCGFPPYIIAELSANHN.....GKIENALDIVSAAKA.....SGADA.....VK
  36 -QEINIAGIQIGQNHPPFIVAEMSGNHN.....QSLEHALEIVEAAAK.....AGVNA.....LK
  37 ----------------VFIIAEAGVNHN.....GDLQLARKLVDAAVE.....AGADA.....VK
  38 --FELCPGRVVGGDHPCFIIAEIGQNHQ.....GDIEIAKKMIKMAKD.....CGADC.....AK
  39 -----------------LIIAEAGVNHN.....GDLNLAKKLIEVAAK.....SGADF.....VK
  40 ----------------LLLIAELSANHN.....QEKNLALETLHAAKE.....SGANA.....VK
  41 --SFKIGNRQIGADAPPFIIAEMSGNHN.....QSLDVALQIVEAAAK.....AGAHA.....LK
  42 ------------TDKKVFIIAELSANHA.....GSLEMALKSIKAAKK.....AGADA.....IK
  43 ------------TDKKVFIIAELSANHA.....GSLEMALKSIKAAKK.....AGADA.....IK
  44 -TEIAIAGRPVGPDHPPFIIAEMSANHN.....GDLGRALALLEAAAK.....AGADA.....VK
  45 ------------TDKKVFIIAELSANHT.....GSLEMALQSIKAAKK.....AGADA.....IK
  46 ---ILVEGISLSQNSPAFVIAEIGNNHN.....GSFELAKKLVREAKL.....AGADC.....AK
  47 ----DINGRKIGENYPAYIVAEIGANHN.....GDVNLAKRMIEVAAE.....CGVDA.....VK
  48 ---ILVEGISLSQNSPAFVIAEIGNNHN.....GSFELAKKLVREAKL.....AGADC.....AK
  49 --EFKIGNRSVGYNHEPLIICEIGINHE.....GSLKTAFEMVDAAYN.....AGAEV.....VK
  50 ----------------IYIVAEIGCNHN.....GDFNLAKKMVEEAKK.....AGVDA.....VK
  51 -----IDKLTISQKN-PLIIPEIGINHN.....GSLEIAKLMVDAAKR.....AGAKI.....IK
  52 -----IDKLTISQKN-PLIIPEIGINHN.....GSLEIAKLMVDAAKR.....AGAKI.....IK
  53 ---VVIAGRKLGPQHPPLVIAEIGINHE.....GDCDKALRMVEAAAQ.....AGCEC.....VK
  54 --SMKLGNVPVGAENPPYVIAEIGSNHN.....GDMNLCRQLIDAAAE.....AGAHA.....VK
  55 ----------------TLIIAEAGVNHN.....GDMNIAEKLINVAFD.....AGVDI.....VK
  56 ----------------TLIIAEAGVNHN.....GDLNLAKKLIEIAAD.....SGADF.....VK
  57 ----------------VYVIAEIGVNHN.....GSLDLALESIDKAKE.....CGANA.....VK
  58 ---FKIGSTIISENHKPFVIAEMSGNHN.....QSLDRALAIVDAAAA.....AGAHA.....LK
  59 ----NIANRSIGVTKPPFIIAEMSGNHN.....QSLDRAFSIVEAAAH.....SGAHA.....IK
  60 ----QIGDFLIADQNPAFIIAEVGNNHN.....GDIGLAKELVNLAVE.....AGADC.....VK
  61 -----IGSKKIGPEHPPFIIAELSGNHN.....GSLERALKLVEEAAR.....AGAHA.....VK
  62 -----------------LVIAEAGVNHN.....GSLSMALELVDAAAH.....CGADV.....VK
  63 ---------------KTFIIAEAGVNHN.....GDIRLAKQLIDAAAD.....AGVDA.....VK
  64 ----------------TLVIAEAGVNHN.....GDLQLAKSLIDVARD.....AGADV.....VK
  65 ---IEIAGRKIGADHSPYVICELSGNHN.....GSLERCLAMVDAAAD.....TGCDA.....IK
  66 ---------------PPKIVAELSANHN.....QDLNLAKESLHAIKE.....SGADF.....VK
  67 ----------------IYIVAEIGCNHN.....GSVDIAREMILKAKE.....AGVNA.....VK
  68 ----------------PKIVAELSANHN.....QDLNLAKESLHAIKE.....SGADF.....VK
  69 ---IRIGNRLLGDGEPCYVIAEVGNNHN.....GDFDRAIALVDAAVA.....AGADC.....AK
  70 ----QLGSRRIGDGEPSFVIAEIGNNHN.....GDISIALQLIDAAHS.....AGADC.....AK
  71 ----------------CFIIAEAGVNHN.....GDLQLAKELVYAAKE.....SGADA.....VK
  72 -----------------YIIAEAGVNHN.....GSLEMAKKLVDVAKE.....SGADA.....VK
  73 -----------AKSHTPLIIAELSANHN.....QSLEIAKDSIRAIAA.....CGADG.....VK
  74 ---------------RAFIIAEAGVNHD.....GDIQRAKRLIDVAAE.....AQADA.....VK
  75 ------------TDKKVFIIAELSANHA.....GSLEMALKSIKAAKK.....AGADA.....IK
  76 ----------------VFIIAEAGVNHN.....GSLKVALELIDAAKE.....AGADA.....VK
  77 ---------------SVYIIAEIGQNHQ.....GCVETAKKMIWEAKK.....AGCHC.....VK
  78 -----------------LIIAEAGVNHN.....GQEELAFALVDAAHE.....AGADI.....VK
  79 -----------------LIIAEAGVNHN.....GDEALAFKLVDAAHQ.....AGADI.....VK
  80 --------------RAVFVIAEAGVNHN.....GDRDLAFKLIDVAAQ.....AGVDA.....VK
  81 -----------------LIIAEAGVNHD.....GSLEKALALVDAAAD.....AGADI.....VK
  82 ------------------VVAEIGQNHQ.....GSLSTAKQMIKAAKE.....CGADC.....VK
  83 ----------------------------.....---------VDAAHK.....AGAEI.....IK
  84 -----IGNKEILKKGKPFFIADIAANHD.....GDLERAYKLIELAKE.....AGADV.....AK
  85 ----AIGDILVGPGQPTYVIGEIGINHN.....GDVDIARQLIEVAAE.....AGCHA.....VK
  86 ----KLGSEIFSVEN-PLTIAEIGTSHN.....GSIQKARNLIDVAAE.....AGAKA.....VK
  87 ----------FWRQQGVYIIAEAGSNWRmghpaRDLAMGKALIDAAVV.....SGADA.....VK
  88 -----FGSKTAGPGHPVYVVGEIGINHN.....GELENAFKLIDAAAE.....AGCDA.....VK
  89 ----TFGTREAGPGRPVYITGEIGINHN.....GELENAFKLIDAAAE.....AGCDA.....VK
  90 ----------------TYIIGEIGQNHN.....GSVDLAKLIIELISRp11dfMPMNA.....VK
  91 -----HRPVPADGIARPYVIAEAGVNHE.....GSMDIARRLIDEACE.....GGADA.....IK
  92 ---------FISDKNPVFVIAEIGGNHE.....GDFAYARKLVSLAIE.....SGADA.....VK
  93 ----------VGDGHPVYVIAEIGINHN.....GSLEVAKKLIEGAAQ.....AGCDA.....VK
  94 -------SPLAPAGGRAAIIAEVGLNHG.....GDADLAWEMIESAWE.....HGADL.....VK
  95 ---------DLGPEHPPIVVAEIGLNHN.....NDEEIGKKTIAAAKK.....AGAQA.....VK
  96 ---FTIGPFSVEENHPPIFLAEIGTFFN.....QDLGIAEQLLHKIIT.....IR-DK.....VP
  97 ----TCGGRCFRPDADILTIAEIGSAHA.....GSFDRARALIDAAAD.....AAAAA.....VK
  98 ----------------PLFVAEVSSNHH.....RDLERCFRFIDTAAA.....VGCGA.....VK
  99 ----------------PYFIAEVSSNHN.....RDLDRCLAFIETAAG.....CGCDA.....VK
 100 ----------------------------.....---------------.....-----.....--
 101 --------------HSPLFIAEVSSNHH.....RDLQRCIEFIKTAAE.....IGCDA.....VK
 102 ----------------PLFIFEMANNHM.....GNVEHGVALIRAIRE.....SCQGFdfdfgFK
 103 ---------------KIFIVAEIGCNHN.....GDPELAKKMVEIAKE.....CGVDA.....VK
 104 -----------------KVIAEIGCNHK.....GEMEIAHEMIKVAAQf....CKVDI.....VK
 105 -TIIKIGDYEIGGEE---IHVMAGPCSV.....ESRAQIIETAHAVKE.....AGATF.....LR
 106 --IVKVGDIEIGGKN---IVIMAGPCAV.....ESREQLFESAMAVKR.....AGAHF.....LR
 107 --IVKVCGISIGEGKRPVVVA--GPCAV.....EGEEQILKTARAVKK.....AGADL.....LR
 108 ----------------PEVIVMAGPCSV.....EGEAMIIETARAVKA.....AGAQV.....LR
 109 --IVDVKGELIGNGTQTFI---MGPCAV.....ESLEQVRQVGQAMKD.....QGLKL.....MR
 110 --IVDVKGELIGNGTQTFI---MGPCAV.....ESLEQVRQVGQAMKD.....QGLKL.....MR
 111 --IVDVKGELIGNGTQTFI---MGPCAV.....ESLEQVRQVGQAMKD.....QGLKL.....MR
 112 --VVKVGDVAIGEGKRPVVVA--GPCAV.....EGEEQIVRTARAVKK.....YGADL.....LR
 113 --VITVKDVAIGGESVTLI---AGPCAV.....ESIDQMMLAAEKVRL.....AGAKI.....LR
 114 -----------GGKE---IIVMAGPCSV.....EGEEQIIETAKAVKA.....AGAQV.....LR
 115 --VIRAGGVPIGPGTLTVI---AGPCAV.....ESPEQTLEAARMARS.....AGASM.....LR
 116 --IITTKHSVIGGGN---FVFMAGPDSI.....ESPEHVKEMGEDVKQ.....AGATI.....LR
 117 --VIRAGGVPIGPGTLTVI---AGPCAV.....EVPGQTLEAARMARS.....AGASM.....LR
 118 ----KVGELTFGGEEKIII---SGPCSV.....EKFETMEKIAKTLKE.....KGTHM.....LR
 119 --VLDIDGVRIGGGEAPIVIA--GPCSI.....ESEEQMEQTAAFLQG.....KGVKI.....LR
 120 -------------------IVMAGPCSV.....ESESQVLETARALKR.....LGVNV.....LR
 121 ----------------------------.....---------------.....-----.....--
 122 ----------------------------.....---------------.....-----.....--
 123 ----------------------------.....---------------.....-----.....--
 124 ----------------------------.....---------------.....-----.....--
 125 ----------------------------.....---------------.....-----.....--
 126 ----------------------------.....---------------.....-----.....--


              60             70        80        90        100       11
              |              |         |         |          |         
   1 FQMFQADRMYQKDP.....GLYKTAAGKDVSIFSLVQSMEMPAEWILP.LLDYCREKQVIFLSTV
   2 FQKSELEFKFNRKAle...RPYTSKHSWGKTYGEHKRHLEFSHDQYRE.LQRYAEEVGIFFTASG
   3 FQKSELEFKFNRKAld...RPYTSKHSWGKTYGEHKRHLEFSHDQYRE.LQRYAEEVGIFFTASG
   4 FQKSELEFKFNRKAld...RPYTSKHSWGKTYGEHKRHLEFSHDQYRE.LQRYAEEVGIFFTASG
   5 FQKSELEFKFNRKAle...RPYTSKHSWGKTYGEHKRHLEFSHDQYRE.LQRYAEEVGIFFTASG
   6 FQSYHTEDFISKK-.....----------SEYYELFKSLELSEEEFYE.LKEYAEKIGIMFISTP
   7 FQKSELEFKFNRKAle...RPYTSKHSWGKTYGEHKRHLEFSHDQYKE.LQSYAQEIGIFFTASG
   8 FQKSELEFKFNRKAle...RPYTSKHSWGKTYGEHKRHLEFSHDQYKE.LQSYAQEIGIFFTASG
   9 FQKSELEFKFNRKAle...RPYTSKHSWGKTYGEHKRHLEFSHDQYKE.LQSYAQEIGIFFTASG
  10 IQTYTPDTMTINCDkky..FHINDGTWKGENLYGLYQKANTPWEWHAR.LKEEAQKAGIDFFSTP
  11 FQTFKAEKLISKFApka..EYQKATTGTADSQLEMTKRLELSFEEYLE.MRDYAISKGVETFSTP
  12 FQKSELEYKFNKKAle...RPYTSKHSWGKTYGEHKRHLEFSHEQYRE.LQQYAKQVGIFFTASG
  13 FQTFKAEKLISKFApka..EYQKATTGTADSQLEMTKRLELSFEEYLE.MRDYAISKGVETFSTP
  14 IQTYRPDTITLNSDlpd..FRISGGLWGGKTLYELYEWAHTPWEWHTP.MFEYARKIGVTIFSSP
  15 FQTFKAEKLISKFApka..EYQKETTGTADSQLEMTKRLELSFEEYLE.MRDYAISKGVETFSTP
  16 FQTFKAEKLISKFApka..EYQKATTGTADSQLEMTKRLELSFEEYLE.MRDYAISKGVETFSTP
  17 FQMFQADRMYQKDP.....GLYKTAAGKDVSIFSLVQSMEMPAEWILP.LLDYCREKQVIFLSTV
  18 LQTYTADTITFECDsee..FQIHGGLWDGKNLYQLYKEAQMPWEWHQP.LFEKAKELGITIFSSP
  19 LQTYTADTMTIDCDqpe..FMIRGGLWDGYKLYDLYQWAQTPFDWHKA.MFEHARKIGITVFSTP
  20 FQTFISKNLTTKNAsk...AEYQKQTKSEESQYDMLKRYELSFDEFSE.LSRYCQDKNIEFLSTA
  21 HQTHIVEDEMSKAA.....KKVIPG-NAKISIYEIMQKCALNYKDELA.LKEYTEKLGLVYLSTP
  22 HQTHIVEDEMSKAA.....KKVIPG-NAKISIYEIMQKCALDYKDELA.LKEYTEKLGLVYLSTP
  23 HQTHIVEDEMSKAA.....KKVIPG-NAKISIYEIMQKCALNYKDELA.LKEYTEKLGLVYLSTP
  24 HQTHIVEDEMSKAA.....KKVIPG-NAKISIYEIMQKCALDYKDELA.LKEYTEKLGLVYLSTP
  25 HQTHIVEDEMSKAA.....KKVIPG-NAKISIYEIMQKCALDYKDELA.LKEYTEKLGLVYLSTP
  26 HQTHIVEDEMSKAA.....KKVIPG-NAKISIYEIMQKCALDYKDELA.LKEYTEKLGLVYLSTP
  27 FQTFKAEKLISKFApka..EYQKATTGTADSQLEMTKRLELSFEEYLE.MRDYAISKGVETFSTP
  28 FQKSELEYKFNKKAle...RTYNSPHSWGKTYGEHKRHLEFSHDQYRE.LQKYAKEVGIYFTASG
  29 FQTFVTEDVVSINTpka..EYQKHTTESSESQFEMIKKLELSKTDHKE.LMKHAEQKNIMFLSTP
  30 HQTHIVEDEMSKAA.....KKVIPG-NAKISIYEIMQKCALDYKDELA.LKEYTEKLGLVYLSTP
  31 LQTYTPDTITFDSDneyf.QIKQGTIWDGTTLHKLYEEAYTPWQWQPK.LKEIAEEEGLICFSSP
  32 HQTHIVEDEMSKAA.....KKVIPG-NAKISIYEIMQKCALDYKDELA.LKEYTEKLGLVYLSTP
  33 LQTYRPDTITLDSDade..FRIQGGLWGGKTLYQLYSEAYMPWDWHVP.LFEHARKTGITIFSSP
  34 LQTYTHETITIDCDsed..FQIHGGLWDGQTLYELYKGAHMPWEWHQT.LFEKAKELDITIFSSP
  35 LQTYKPETITLRSDaee..FKITEGLWRGRTLYDLYEEAHMPWEWHKP.IFEHAARLGITIFSSP
  36 IQTYTADTMTLDINegefyINNPDSLWHGNSLYQLYQQAYTPWEWHKP.IFDRCKELGIIGFSTP
  37 FQTFKAEEVATPGAeraq.YQKDNMPGKDESQLEMIKRLELSYAQFRE.LYAYCRQKGIIFLSSP
  38 FQKSELEDKFNRRAle...RPYTSKHSWGKTYGEHKRHLEFSHDQYEE.LQKYAEEVGIFFTASG
  39 FQSFKAELCVSKNAkka..AYQLKTTAKDESQLEMIKKLELDFNAHQL.LISHAKQCGIAFLSTA
  40 LQTYTADTLTLDSSkpyf.QIQSDTLWDGETLYSLYQKAYTPWEWHEE.LFEYAKKLGLLCFSTP
  41 LQTYTAETMTLDLAqgeffIKDPNSLWAGTSLYDLYEKAHTPWEWHAP.IFARARELGMLAFSTP
  42 IQTYTPDSLTLNSDked..FIIKGGLWDKRKLYELYESAKTPYEWHSQ.IFETAQNEGILCFSSP
  43 IQTYTPDSLTLNSDked..FIIKGGLWDKRKLYELYESAKTPYEWHSQ.IFETAQNEGILCFSSP
  44 LQTLKPDAITIDCDkpd..FVIEGGPWGGRKLFDLYAEAQTPWEWHSK.LFQRGKELGLIVFSSP
  45 IQTYTPDSLTLNSDked..FIIKGGLWDKRKLYELYESAKTPYEWHSQ.IFETTQNEGILCFSSP
  46 FQMRNLDALYRNSGn....ANDAEEDLGSQYTLDLLNKFQLSDDELFR.IFDYCREESLIPLCTP
  47 FQTYTAKELVSDTDril..TWGPCGKQKTETIGKMFDRIALPREAHKE.VFEYANKLGLMAFSTP
  48 FQMRNLDALYRNSGn....ANDAEEDLGSQYTLDLLNKFQLSDDELFR.IFDYCREESLIPLCTP
  49 HQTHIVEDEMSDEA.....KQVIPG-NADVSIYEIMERCALNEEDEIK.LKEYVESKGMIFISTP
  50 FQTFKADQLISKYApka..EYQIKVTGNQESQLEMTRKLELPYEEFIK.LEEYAKELGLDVFSTP
  51 HQTHIVEDEMSQEA.....KNVIPG-NANISIYEIMEQCALNYKDELA.LKEYVEKQGLVYLSTP
  52 HQTHIVEDEMSQEA.....KNVIPG-NANISIYEIMEQCALNYKDELA.LKEYVEKQGLVYLSTP
  53 IQTHIIEDEMVPNDvv...-----PGNAKESIWNIMSRCALTREEEVC.IKRRTEELGMIFLSTP
  54 FQSWTENSLIAREEyern.TEYSDKKRHFGSLRDMVKTYQLTTDQHRE.AHAYCRERGIAFCSTP
  55 FQTFHATELASNFAkka..DYQISNMQEGGTQVSMLKKLELSVQDHFR.LIEICKKKNIQFLSTA
  56 FQSFKAKNCISTKAkka..PYQLKTTANDESQLQMVQKLELDLKAHKE.LILHAKKCNIAFLSTP
  57 FQTFKTNKLVSKKApma..KYQKDNLKEDSSQFEMLKKLELSQSDFIR.IKDYCIQNKIDFLSTP
  58 LQTYTADTITFNGTsdefiIKDENSIWKNQNLHQLYQQAYTPWEWHAP.IFERAKSHGMIAFSSP
  59 LQTYTADSITLNVRggdfeITDKSSLWYGNNLHQLYSHASTPWEWHEP.IFNHAKDCGLICFSSP
  60 FQMRDLSSLYSNQGr....NAEAGYDLGSQYTLDLLNKFQLNHDELCQ.VFDYCRQQDILPLCTP
  61 LQTYTPDTITLNVRrseflIEEKSSLWTGRYLYDLYQEAHMPWEWHQP.IFEKCKVLGLVAFSTP
  62 FQSFDPQQIASRHAgka..AYQKRTTDATESQQAMLARLALSVEDHHQ.LLQRCQQRGIGFLSSP
  63 FQTWKTELLVTEDAkma..EYQVENTQREETQFEMLKRLELSYDDFTE.LKSYCDDKGITFMSTP
  64 FQTFQASQLATQHAeqa..AYQQKALDSSEGQLAMLKRLELHPEHHVE.LIEYCMQKNIEFLSTA
  65 IQTYTADTITLDVDrpe..FKIHGGLWDGRTLYELYEEAHTPFEWHAA.IFERARQRGVTIFSSP
  66 LQTYTPSCMTLNSKedp..FIIQGTLWDKENLYELYQKASTPLEWHAE.LFELARKLDLGIFSSP
  67 FQTFKADKLISAIApka..EYQIKNTGELESQLEMTKKLEMKYDDYLH.LMEYAVSLNLDVFSTP
  68 LQTYTPSCMTLDSKedp..FIIQGTLWDKENLYGLYQKASTPLEWHAE.LFELAKKLDLGIFSSP
  69 FQMRKLDEVYRASS.....LSGKDDDLAVEYTLDLLRRFELTTEQQKK.IADYCASKGIQYLCTP
  70 FQMRDMSKLYSNAGd....SNDMASDLGTQYTLDLLERFQLSDDELFR.CFDYAASKGLVPLCTP
  71 FQTFKADTLVNKTVeka..EYQKNNAPESSTQYEMLKALELSEEDHYL.LSELANSLGIEFMSTG
  72 FQTFKAENIVSKKApka..DYQVETTGNNETQLQMIQKLELDEEAHAV.LVEYCKKKGIDFLSTP
  73 LQTYTPECLTLQSNephf.CISGGTLWDKRNLYELYKEAQTPWEWHKE.LFSLAKELGLLIFSSP
  74 FQTWRPGEITGRFAykv..NYLEATTEQAESRYELSCRLALPYPVFRE.LKSHCEARGILFLSTP
  75 IQTYTPDSLSLNSDked..FIIKGGLWDKRKLYELYESAKTPYEWHSQ.IFETAQNEGILCFSSP
  76 FQTFKSGAVISMDApka..EYQKTTTGTSESQLDMVRKLELSAEDHIQ.LLQHCEKRGILFLSTP
  77 FQKSDLPAKFTRSAld...REYISDHAWGKTYGEHKEYLEFSKDQYLQ.LQAHCKELNVDFTASA
  78 FQTFKAKNLVTEEAkqa..EYQVTNTKKQESQLAMLSRLELSYEIHHD.LVKYCNSLGIEFLSTA
  79 FQTFKAKNLVTEQAkqa..DYQVANTQKQESQLAMLSRLELSYAAHHQ.LVKHCESLGIEFLSTA
  80 FQTFNAKRLASRSApka..NYQKHTTDVTESQLAMLKKLELPKEWHFE.LQAHAHHNGIEFISTA
  81 FQTFNAKALAGGAAkka..DYQQRTTDAAESQLAMLERLELPQAAHHT.LIERAAERGIEFLSTP
  82 FQRSNLAEKFTVSAla...RPYTGPNSWGRTYGEHKAWLEFSSDEYRE.LQRFATDHNIVFTASA
  83 HQTHVIEDEMSNKA.....KNVIPG-NTDVSIFDVMARCALNEPDEIK.LKEYVESKGMIYLSTP
  84 FQNFNAKTIVSKKGfetlgKQLSHQANWKKSVYEVYKDASINPDWTEL.LKRKCDEVGIEYMTSP
  85 FQKRTPEICVPKEQr....DKIRQTPWGEMTYLEYKHRVEFGRDEYTE.IAKICEENGLQWFASP
  86 FQIVYADEILHPNT.....GYVDLP-TGKIPLYDRFKSLELPVSFYKE.LAEYSRSKKLLFSASP
  87 FQTYRPEKVYVANAgq...SNYLAESGIKQDIRDIFADLAMPYSMIED.LAGYCKKAGIQFLSTG
  88 FQKRTPEICTPRDQw....DIERDTPWGRMTYIDYRHRVEFGEDEYRQ.IDEYAKSKNIDWFASP
  89 FQKRTPEICTPRDQw....DIERDTPWGRMTYIDYRHRVEFGEDEYRQ.IDDYCRTKNIDWFASP
  90 MTKRDLSEELAVSQmn...QIYDNPNSFGRTYGEHRAFLELDDQAHFE.IYKYAKSLGLDFIETL
  91 FQTYKAATLASKDSp....AYWDTTKEPTKSQYELFTRHDKFWKGEFEaLKRHCDTAGIEFLSTP
  92 LQVYAGDALVSRVE.....---------SPDRNRHFKKFELSRGQYEA.LIDMCRHAGVQFMASA
  93 FQKRTPELCVPMDQr....LIERDTPWGRMTYMDYRYKVEFGFEEYSE.IDAYCREKGIAWFASC
  94 LQSFAPGGLLHPS-.....----------LPYAASMEGMMLSLRQHEA.LFERARRQGIALITTP
  95 FQSYVTEEFIDVH-.....------NPEAKVLVDIFKKYELSETMHKK.FQKTAEEEGLIFFSTP
  96 YQPLMLKTEILNNPn11etYTSKSGEVRKENYRSLIERKVLPLEHYSM.LFSLLKNANLPFIVSI
  97 FQLIYAHEILHPLT.....GAVRLP-SGAVSLYQRFEELEVPLSFYAQ.CFNHARSRGMLVGISP
  98 FQLFRVEELFAPE-.....------VLAKSPVLRARKAWELPVEFLSP.LAERCRKQGIQFSCTP
  99 FQLFRLDELFAPE-.....------VFAAMPQVTGRRAWELPEDYLPV.LAQSCRRHGVAFSATP
 100 --------------.....-----------------------------.----------------
 101 FQLFKIEELFAPE-.....------ILSKSEMHRKRKEWELPVSFLPQ.LKQSCDEYGIQFSCTP
 102 LQYRNLDTFIHSS-.....----FKGRDDVKYVKRFEETRLQPEQMQK.LVAEMKANGFKAICTP
 103 FQTFKADLLISKYApka..EYQKKVTSSDESQLEMTKKLELPFDKFIE.LEKYARGLGLEVFSTP
 104 FQKRTPVELLTPEEyna..PHPVPHNSYGKTYGEHREFLEFNLDQHKQ.LKKWCDDWGVVYSTSV
 105 --------------.....------GGAFKPRTSPYAFQGLEEEGLKL.LAEAREETGLLVITEV
 106 --------------.....------GGAYKPRTSPYSFQGLEEEGLKM.LSEARELTGLKIVTEV
 107 --------------.....------GGAFKPRTGPHTFQGMREEGLKL.LAKAREATGLPIVTEV
 108 --------------.....------GGAFKPRTSPYSFQGLEEEGLKL.LAKAREETGLPIVTEV
 109 --------------.....------GGAFKPRTSPYDFQGLGVEGLQI.LRQVADEFDLAIISEI
 110 --------------.....------GGAFKPRTSPYDFQGLGVEGLQI.LRQVADEFDLAIISEI
 111 --------------.....------GGAFKPRTSPYDFQGLGVEGLQI.LRQVADEFDLAIISEI
 112 --------------.....------GGAFKPRTGPHTFQGLREEGLKL.LAIARRETGLPIVTEV
 113 --------------.....------GGTYKPRTSPYAFQGLEEEGLKI.LNTAGRFAGLPTVTEV
 114 --------------.....------GGAFKPRTSPYSFQGLEEEGLKL.LAKAREITGLPIVTEV
 115 --------------.....------GGAFKPRTSPYSYQGLGERGLRI.LADVRAETGLAVVTEV
 116 --------------.....------GGAFKPRTSPYSFQGNGEEGLKA.HRAAADALGMDMVTEI
 117 --------------.....------GGAFKPRTSPYSYQGLGERGLRI.LADVRAETGLAVVTEV
 118 --------------.....------GGAFKPRTSPYDFQGLGFEGFKI.LKALREKFNMPVVSEV
 119 --------------.....------GGAYKPRTSPYGFQGMGVDGLIL.GSRVAKEHGQLFVTEV
 120 --------------.....------GGAFKPRTYPESFQGLGEDGLKI.LAMAREETGMSIVTEA
 121 --------------.....-----------------------------.----------------
 122 --------------.....-----------------------------.----------------
 123 --------------.....-----------------------------.----------------
 124 --------------.....-----------------------------.----------------
 125 --------------.....-----------------------------.----------------
 126 --------------.....-----------------------------.----------------


      0         120        130       140              150        160   
     |           |          |         |                |          |   
   1 CDEGSADLL.Q.S.TSPSAFKIASYEINHLPLLKYVAR.L...NRP...MIFSTAG.AEISDVHE
   2 MDEMAVEFL.H.E.LNVPFFKVGSGDTNNFPYLEKTAK.K...GRP...MVISSGM.QSMDTMKQ
   3 MDEMAVEFL.H.E.LNVPFFKVGSGDTNNFPYLEKTAK.K...GRP...MVISSGM.QSMDTMKQ
   4 MDEMAVEFL.H.E.LNVPFFKVGSGDTNNFPYLEKTAK.K...GRP...MVISSGM.QSMDTMKQ
   5 MDEMAVEFL.H.E.LNVPFFKVGSGDTNNFPYLEKTAK.K...GRP...MVISSGM.QSMDTMKQ
   6 LDLKYVDIL.N.K.MNVPAFKIASGDLTFYPLLEKVAK.T...GKP...VILSTGM.SDIGEIWE
   7 MDEMAVEFL.H.E.LNVPFFKVGSGDTNNFPYLEKTAK.K...GRP...MVISSGM.QSMDTMKQ
   8 MDEMAVEFL.H.E.LNVPFFKVGSGDTNNFPYLEKTAK.K...GRP...MVISSGM.QSMDTMKQ
   9 MDEMAVEFL.H.E.LNVPFFKVGSGDTNNFPYLEKTAK.K...GRP...MVISSGM.QSMDTMKQ
  10 FDKSAVDFL.E.D.LGVEFYKIASFEVVDIPLIKYIAS.K...KKP...IIMSTGM.ATLGEIEE
  11 FDEESLEFL.I.S.TDMPIYKIPSGEITNLPYLEKIGK.Q...QKK...VILSTGM.AVMEEIHQ
  12 MDEMAVEFL.H.E.LDVPFFKVGSGDTNNFPYLKKTAQ.K...GRP...MVVSSGM.QSMETMQH
  13 FDEESLEFL.I.S.TDMPIYKIPSGEITNLPYLEKIGK.Q...QKK...VILSTGM.AVMEEIHQ
  14 FDPTAVDLL.E.D.LNAPAYKIASFEAIDLPLIKYVAA.T...GKP...MIISTGM.ADLEEIQE
  15 FDEESLEFL.I.S.TDMPIYKIPSGEITNLPYLEKIGK.Q...QKK...VILSTGM.AVMEEIHQ
  16 FDEESLEFL.I.S.TDMPIYKIPSGEITNLPYLEKIGK.Q...QKK...VILSTGM.AVMEEIHQ
  17 CDEGSADLL.Q.S.TSPSAFKIASYEINHLPLLKYVAR.L...NRP...MIFSTAG.AEISDVHE
  18 FDFTAVDLL.E.D.LDAPAYKIASFELIDLPLIKRVAQ.T...GKP...MIMSTGM.ANAEEIAE
  19 FDESAVDLL.E.A.LDTPAYKIASFELTDLPLIRYVAA.T...GKP...MIMSTGM.ASEAEIEE
  20 FDFESIEFL.K.S.LDMKRWKIPSGEITNLPYLIKIAK.L...NKP...VILSTGM.STMDEIKK
  21 FSRAGVNRL.E.D.MGVSAFKIGSGECNNYPLIKHIAA.F...KKP...MIVSTGM.NSIESIKP
  22 FSRAGANRL.E.D.MGVSAFKIGSGECNNYPLIKHIAA.F...KKP...MIVSTGM.NSIESIKP
  23 FSRAGANRL.E.D.MGVSAFKIGSGECNNYPLIKHIAA.F...KKP...MIVSTGM.NSIESIKP
  24 FSRAGANRL.E.D.MGVSAFKIGSGECNNYPLIKHIAA.F...KKP...MIVSTGM.NSIESIKP
  25 FSRAGANRL.E.D.MGVSAFKIGSGECNNYPLIKHIAA.F...KKP...MIVSTGM.NSIESIKP
  26 FSRAGANRL.E.D.MGVSAFKIGSGECNNYPLIKHIAA.F...KKP...MIVSTGM.NSIESIKP
  27 FDEESLEFL.I.S.TDMPIYKIPSGEITNLPYLEKIGK.Q...QKK...VILSTGM.AVMEEIHQ
  28 MDEMAVEFL.H.E.LGVPFFKVGSGDTNNFQYLKKTAQ.K...GRP...MVISSGM.QSLETMRR
  29 FDERSVDLL.V.E.LGVPLIKISSGEITNHPLLKYISR.K...GIP...IILSTGM.STLEEVAE
  30 FSRAGANRL.E.D.MGVSAFKIGSGECNNYPLIKHIAA.F...KKP...MIVSTGM.NSIESIKP
  31 FDNTSVDFL.E.K.MEVPAYKVASFELTDIPFIEYIAS.K...GKP...VIMSTGI.AEMGEIYE
  32 FSRAGANRL.E.D.MGVSAFKIGSGECNNYPLIKHIAA.F...KKP...MIVSTGM.NSIESIKP
  33 FDNTAVDLL.E.D.LNAPAYKIASFEAVDLPLIRYAAG.T...GKP...MIISTGM.ADDEEIAE
  34 FDFTAVDLL.E.E.LNAPAYKIASFELVDLPLIARVAK.T...GKP...MIMSTGM.ANKEEIAE
  35 FDSTAVDLL.E.D.LNTPAYKIASFEAVDLPLIRYAAS.T...GKP...MIISTGM.ANAEEIEE
  36 FDASAVDFL.E.S.LEVPFYKIASFENTDFPLIRKVAS.T...RKP...MIISTGM.ATVAELDE
  37 FDQESIDFL.A.E.LGVPYFKIPSGEITNYPFLRRIGG.K...KRP...VILSTGM.ATLGEVEG
  38 MDEMAVEFL.H.E.LKVPFFKVGSGDTNNFPYLEKTAK.K...GRP...MVVSSGM.QSMATMRR
  39 FDLESIELL.D.D.LGLEVFKIPSGEITNLPYLKKIAK.L...NKK...IILSTGM.SNLGEIEA
  40 FDPTAVDFL.E.T.LGNPIYKIASFEINDIPLIRYAAR.L...QKP...MILSTGI.ASLEEISE
  41 FDDSAVDFL.E.S.LDVPAYKIASFENTDLPLIRRVAA.T...GKP...LIISTGM.ASIAELDE
  42 FAKEDVEFL.K.R.FDPIAYKIASFEANDENFVRLIAK.E...KKP...TIVSTGI.ATEEELFK
  43 FAKEDIEFL.K.R.FDPIAYKIASFEANDENFVRLIAK.E...KKP...TIVSTGI.ATEEELFK
  44 FDMAAVDFL.A.G.LDAPAFKIASFEMADPGLVAHAAA.K...GKP...IIVSTGM.AGLGDIAA
  45 FAKEDVEFL.K.R.FDPIAYKIASFEANDENFVRLIAK.E...KKP...TIVSTGI.ATEEELFK
  46 WDEESFFKL.E.S.YGIPAYKIASADFTNHELIRLVAK.S...GKP...VICSTGM.STEDEIMD
  47 FSIKGVEFL.N.E.LEVPCFKVAASDVDYLDILKEIGK.T...KKP...VMLSLGK.CTLGEADL
  48 WDEESFFKL.E.S.YGIPAYKIASADFTNHELIRLVAK.S...GKP...VICSTGM.STEDEIMD
  49 FSRAAALRL.Q.R.MDIPAYKIGSGECNNYPLIKLVAS.F...GKP...IILSTGM.NSIESIKK
  50 FDFESIDFL.A.S.RNQKMWKIPSGELLNLPYLEKISR.LpieGKE...IVLSTGM.ATIEEIKA
  51 FSRAAANRL.E.D.MGVSAYKIGSGECNNYPLIKHIAQ.F...KKP...MIISTGM.NSIESIKP
  52 FSRAAANRL.E.D.MGVSAYKIGSGECNNYPLIKHIAQ.F...KKP...MIISTGM.NSIESIKP
  53 FSRAAADQL.E.S.MGVTAYKIGSGECNNYPLIRHVAS.F...GKP...VILSTGM.NDISSIEP
  54 FSPEEADLL.E.S.LDVPFFKIASMDIVHLPFLKYVAR.K...RRP...MLLSTGM.ATLAEIEA
  55 FDLKSIDLL.I.E.LGLSLWKIPSGEITNYPYLKKIGE.L...NQK...IILSTGM.ANLGEIES
  56 FDLESVDLL.N.E.LGLKIFKIPSGEITNLPYLKKIAK.L...NKK...IILSTGM.ANLGEIEE
  57 FDEESADFL.K.Q.IGVQGFKIGSGDLTNLPFLRKIDM.Y...GLP...VLLSTGM.ADIHEVSE
  58 FDTTAVDFL.E.S.LDVPCYKIASFENTDHILLKKVAQ.T...NKP...VIMSTGV.STIADIQE
  59 FDEKAVDFL.E.S.LDTPAYKIASFENCHLPLIKKVAQ.T...GKP...LIISTGL.ASIAELDE
  60 WDLVSAHVL.D.E.YGLEAFKVASADFTNYEMLETLAK.T...GKP...LLCSTGM.SSEAEIKG
  61 FDESAVDFL.E.A.LDVPCYKIASPEIVDLPLIRKIAS.L...GKP...VLLSTGG.ANLEEITE
  62 FDLPSLALL.V.G.LGCRPFKIPSGEITNLPLLRGIGA.T...GEA...VLLSTGM.ATLGEVEA
  63 DEEQSATFL.D.G.L-QAVFKIGSGELTNTPFLRHIAS.F...AKP...VILSTGM.GYLSEVEH
  64 FDISSIGLL.A.T.LKPKRWKVPSGEITNLPYLRKIGR.Q...GQP...VILSTGM.ANLGEIEA
  65 FDETAVDLL.D.S.LGAPAFKIASFEAVDLPLIKYAAA.K...GKP...LIISTGM.ANLTEMQT
  66 FSSQALELL.E.S.LNCPMYKIASFEIVDLDLIEKAAR.T...QKP...IILSSGI.ATHTELQD
  67 FDEDSIDFL.A.S.LKQKIWKIPSGELLNLPYLEKIAK.L...PIPdkkIIISTGM.ATIDEIKQ
  68 FSSKALELL.E.S.LDCPMYKIASFEIVDLDLIEKAAR.T...QKP...IILSSGI.ATHAELQD
  69 WDAKSVAVL.E.G.FGVQAYKVASADLTNLPLLARLIA.T...GKT...LIVSTGM.STTEEIKA
  70 WDETSLEKL.N.G.WGMEGFKVASADFTNHALISQLAA.T...GKP...LICSTGM.ASELEIRS
  71 FDEQSIDFL.I.S.LGVKRLKIPSGEITNVPYLQHCAS.K...KLP...LIISTGM.CDLQEVRV
  72 FDIPSVGLLaK.K.MGVPRLKVPSGEIINAPLLLKVAQ.T...NLP...VIVSTGM.ATLGEIEA
  73 FSPKGVAFL.E.S.LQCPIYKVASFEVMHYELIEAIAK.T...KKP...IIISTGV.ATHKELKT
  74 DGFDSLAFL.VgE.LDMPIVKIGSTEVTHPQYLEAIGR.T...GRP...AILSTGL.STLGEVEK
  75 FAKEDVEFL.K.R.FDPIAYKNRFFEANDENFVRLIAK.E...KKP...TIVSTGI.ATEEELFK
  76 FDVQSAELLvR.E.LGVPQLKVPSGELTNAPFLLKIAG.Y...GLP...VIVSTGM.STLGEAEM
  77 MDERSLEFL.S.A.LNVPFIKIGSGDANNFPLLKKAAN.L...NLP...LVISTGM.QTMQTVER
  78 FDLESLDFLvN.D.LGLTRLKLPSGELTNAPLVLAHAR.T...GCD...LIVSTGM.ATLSEIEA
  79 FDSESLDFLvN.D.LGLTRLKLPSGELTNAPLVLEHAR.T...GCD...LIVSTGM.ATLAEIEM
  80 FDSDSLAFL.A.E.MQLPFFKVPSGELTNGPLLWAFAK.T...GKP...LILSTGM.ATLSEVEQ
  81 FDDASLGFL.L.S.LKLPRIKIGSGDLTNAPLLHAAAR.A...GAT...LILSTGM.ATLSEIEE
  82 MDAASFREL.E.EqLRVPFIKIGSGDADNVPLLRYAAN.R...TIP...LIISTGM.LDWDQVCS
  83 FSRAAANRL.E.R.MGVLAYKIGSGECNNYPLIEHVAS.F...GKP...MIISTGM.NNIDSVKK
  84 YDYASVDLV.D.P.Y-VNAYKIGSGDITWTEILKYILS.K...NKP...ILLATGA.SSMEDVDR
  85 WDVPSVEFL.E.S.FDVVAHKVASASITDHELLRALAA.T...GKP...IILSTGM.STIEEIDA
  86 FGFRSAEEL.A.A.LKPDFIKIASPELNYVQLLKYCAG.F...NIP...MILSSGV.SILKDIEK
  87 FSVEDFQAI.D.P.W-VPLHKIASYEISHLRLLDLAAN.S...GKP...LLLSTGA.SRAEDIAW
  88 WDTEAVAFL.E.K.FDIPAHKVASASLTDDELLRALRG.T...GRT...VILSTGM.STPKQIRH
  89 WDTEAVAFL.E.K.FDVPAHKVASASLTDDELLRALRA.T...GKT...VILSTGM.STPKQIRH
  90 CAKGCLSLL.K.L.FTPDRLKVASRDLTNLPLLEALAE.T...HIP...IILSTGM.AGQRELDN
  91 FDVESAGFL.D.D.L-MDVFKISSSDITNKPFIRFLCD.F...KKP...IILSTGA.AYLHEIAE
  92 WDRERLGWI.E.P.H-VRIHKAGSGDLTAYPMLRALVS.T...GKP...LVLSTGL.STMPEVEA
  93 WDEEAVDFM.E.Q.FNPPCYKAASASLTDLTLLKKTKA.T...GRP...LIISTGM.STMEEVDA
  94 FDAPTLDLC.T.R.FRIAAVKVASMDLDNTAHLRAVAR.T...GLP...VILSCGM.GDHADIGK
  95 LCISSLNLL.I.G.LKVPLIKIASGDVTNKTLLLETAK.S...KLP...VILSSGA.ADFFELNR
  96 YELDTIDFA.I.K.QGACALKTSSSNIVHIPLIRHLAK.T...GLP...LIIDTGR.SSLTDICK
  97 FGPRSATEA.L.A.LKPDFLKVASPELNYPTLISTLAA.A...ELP...LILSSGV.CLLKEIEG
  98 FYLQAVEEL.L.P.Y-VDFYKIASYELLWNDLLRACAA.T...GKP...VILSTGM.ATLDEIGG
  99 FSLQAVHAL.Q.P.H-VDFYKIASYELLWDALLHACAG.T...GKP...VVLSTGM.AALQEVAH
 100 -------LL.N.E.LGLKIFKIPSGEITNLPYLKKIAK.L...NKK...IILSTGM.ANLGEIEE
 101 FYLDAVAEL.E.P.F-VDFYKIASYELLWDDLLAACVK.T...GKP...VVISAGM.ATIEEIDH
 102 FDEESVDLI.E.A.HGIEIIKIASCSFTDWPLLERIAR.S...DKP...VVASTAG.ARREDIDK
 103 FDFESIDFL.A.G.YQQKIWKIPSGEITNLPYIEKIAK.LpiiNKQ...IVLSTGM.STIAEIEE
 104 WDLTAAKEI.V.S.INPELIKIPSACNLKFDMLEYLCKeY...DGE...IHLSFGM.TTNEEEEK
 105 VDVRDVELV.A.H.Y-ADILQIGARNMQNFFLLKEVAK.T...NKP...ILLKRGPsATLEEWMM
 106 MDVHSVEKV.A.E.Y-ADVLQIGARNMQNFSLLKAVGR.M...NKP...VLLKRGLaATLEEWLS
 107 MSPDTVGLV.A.E.Y-ADLLQVGARNMQNFELLKELGR.I...QKP...VLLKRGMsATIEEFLA
 108 VNPETAELV.S.E.Y-SDILQIGARNAQNFALLKKVGQ.L...RRP...VLLKRGMsMTIQEFLM
 109 LNPNDVEMA.L.D.Y-VDVIQVGARNMQNFDLLRAVGK.V...NKP...VLLKRGLaATIDEFIN
 110 LNPNDVEMA.L.D.Y-VDVIQVGARNMQNFDLLRAVGK.V...NKP...VLLKRGLaATIDEFIN
 111 LNPNDVEMA.L.D.Y-VDVIQVGARNMQNFDLLRAVGK.V...NKP...VLLKRGLaATIDEFIN
 112 MSPDTVGLV.A.E.Y-ADLLQVGARNMQNFELLKELGR.I...RKP...VLLKRGMsATLEEFLA
 113 IDLPSLEIA.S.R.Y-VDILQIGARNMQNFRLLQAVGQ.T...RLP...VILKRGLsATIEEWLM
 114 VNPETADLV.A.E.Y-SDILQIGARNAQNFALLKKVGQ.L...RRP...VLLKRGMsMTIQEFLM
 115 IDPGSVDMV.A.S.Y-ADMLQIGARNMQNFALLQAVGS.A...GKP...VLLKRGFsATIEEWLS
 116 LDTRDVDLV.D.S.Y-TDIFQVGTRNMQNFALLKALGK.K...NKP...VVLKRGMsATIDDLLN
 117 IDPGSVDMV.A.S.Y-ADMLQIGARNMQNFALLQAVGS.A...GKP...VLLKRGFsATIEEWLS
 118 LDTRHVEKA.L.D.Y-IDMIQIGSRNMYNYSLLKEVGK.T...NKP...VLLKRGMsATLKEWLN
 119 MDTRDVDVV.S.E.Y-ADILQIGARNMHNFALLREVGR.A...RRP...VLLKRGLsATIEEWLY
 120 MDLESLRLV.E.K.Y-ADIIQIGSRNSQNFPLLKAAGK.T...MKP...VLLKRGFgNTIDELIG
 121 ---------.-.-.------------------------.-...---...-------.ANFEEIAE
 122 ---------.-.-.------------------------.-...---...-------.--------
 123 ---------.-.-.------------------------.-...---...-------.--------
 124 ---------.-.-.------------------------.-...---...-------.--------
 125 ---------.-.-.------------------------.-...---...-------.--------
 126 ---------.-.-.------------------------.-...---...-------.--------


               170             180          190       200           210
                |               |            |         |             |
   1 AWRTI.....RAEGNN.....QIAIM.HCVAKYP...APPEYSNLSVIPMLAAAFPEAV..I..G
   2 VYQIV.....KPLNP-.....NFCFL.QCTSAYP...LQPEDVNLRVISEYQKLFPDIP..I..G
   3 VYQIV.....KPLNP-.....NFCFL.QCTSAYP...LQPEDVNLRVISEYQKLFPDIP..I..G
   4 VYQIV.....KPLNP-.....NFCFL.QCTSAYP...LQPEDVNLRVISEYQKLFPDIP..I..G
   5 VYQIV.....KPLNP-.....NFCFL.QCTSAYP...LQPEDVNLRVISEYQKLFPDIP..I..G
   6 AVKVL.....ENNGCR.....DIILL.HCISSYP...TPYEDVNLNAIKTLKSIFN-IP..V..G
   7 VYQIV.....KPLNP-.....NFCFL.QCTSAYP...LQPEDANLRVISEYQKLFPDIP..I..G
   8 VYQIV.....KPLNP-.....NFCFL.QCTSAYP...LQPEDANLRVISEYQKLFPDIP..I..G
   9 VYQIV.....KPLNP-.....NFCFL.QCTSAYP...LQPEDANLRVISEYQKLFPDIP..I..G
  10 AVETI.....RSQGND.....NFCLL.KCSSAYP...AVPEQMNLKTIAHLKETFN-VP..V..G
  11 AVNIL.....RQNGTT.....DISIL.HCTTEYP...TPYPSLNLNVIHTLKDEFKDLT..I..G
  12 VYKIV.....KEHNQ-.....NFCIL.QCTSAYP...LEPEDVNLRVITEYQKEFPDIP..I..G
  13 AVNIL.....RQNGTT.....DISIL.HCTTEYP...TPYPSLNLNVIHTLKDEFKDLT..I..G
  14 AVDAA.....QAGGCK.....ELAIL.HCVSGYP...APAQDYNLRTITDMQKRHG-LV..I..G
  15 AVNIL.....RQNGTT.....DISIL.HCTTEYP...TPYPSLNLNVIHTLKDEFKDLT..I..G
  16 AVNIL.....RQNGTT.....DISIL.HCTTEYP...TPYPSLNLNVIHTLKDEFKDLT..I..G
  17 AWRTI.....RAEGNN.....QIAIM.HCVAKYP...APPEYSNLSVIPMLAAAFPEAV..I..G
  18 AIATA.....QSNGCQ.....ELVVL.HCVSGYP...APADQYNLRTIADMAERFG-VL..S..G
  19 AVSAA.....REAGCT.....DLVLL.HCISSYP...APMDQAKLRQIAGLESRFG-VT..P..G
  20 AVSVL.....RENGTG.....EITVL.HCTTEYP...APFSDVNLKAMLTIKKELG-VK..V..G
  21 TVKIL.....LDNEI-.....PFVLM.HTTNLYP...TPHNLVRLNAMLELKKEFS-CM..V..G
  22 TVKIL.....LDNEI-.....PFVLM.HTTNLYP...TPHNLVRLNAMLELKKEFS-CM..V..G
  23 TVKIL.....LDNEI-.....PFVLM.HTTNLYP...TPHNLVRLNAMLELKKEFS-CM..V..G
  24 TVKIL.....LDNEI-.....PFVLM.HSTNLYP...TPHNLVRLNAMLELKKEFS-CM..V..G
  25 TVKIL.....LDNEI-.....PFVLM.HTTNLYP...TPHNLVRLNAMLELKKEFS-CM..V..G
  26 TVKIL.....LDNEI-.....PFVLM.HTTNLYP...TPHNLVRLNAMLELKKEFS-CM..V..G
  27 AVNIL.....RQNGTT.....DISIL.HCTTEYP...TPYPSLNLNVIHTLKDEFKDLT..I..G
  28 VYELV.....KQVNP-.....NFCFL.QCTSAYP...LLPEDVNLCIIKEFQSTFPDIP..I..G
  29 AVSVI.....KDAGCE.....DLTLL.HCTSSYP...ARVEDCNLLTMETMADVFD-VQ..V..G
  30 TVKIL.....LDNEI-.....PFVLM.HTTNLYP...TPHNLVRLNAMLELKKEFS-CM..V..G
  31 AVAAC.....RRQGNE.....NVILL.KCSSSYP...SPLEDINLKTIPNMREAFN-CS..V..G
  32 TVKIL.....LDNEI-.....PFVLM.HTTNLYP...TPHNLVRLNAMLELKKEFS-CM..V..G
  33 AIEAA.....RGGGCK.....DLAIL.HCVSGYP...APARDYNLRTIPDMIERFG-LA..T..G
  34 AIKTA.....QENGCK.....ELVVL.HCVSGYP...APADQYNLRTISDIASRFN-VL..S..G
  35 AIVAA.....RDAGCA.....SLAIL.RCVSGYP...APPEDYNLLTIPDMIRRFN-LV..T..G
  36 TVITA.....REAGCQ.....DLILL.KCTSTYP...ATPENSNLLTIPHLHDLFN-VQ..V..G
  37 ALRVL.....REAGAS.....DITLL.HCTTSYP...APPEEVNLRAMLTMKHAFA-LP..V..G
  38 VYKTV.....KEHNQ-.....NFAIL.QCTSAYP...LEAEDVNLRVITEYQKEFPDIP..I..G
  39 ALEVL.....CKEGTQra...NITLL.HCTTEYP...APFNEVNLKAMQTLKNAFN-LD..V..G
  40 AVEAC.....RNEGNE.....DITLL.ACTSSYP...APLEEANLARIPDLKRRFG-VK..V..G
  41 TVRAA.....REAGCK.....DLVLL.KCTSTYP...ATPLNSHVRTIPHLRELFG-CE..V..G
  42 ICEIF.....KEEKNP.....DLVFL.KCTSTYP...TAIEDMNLKGIVSLKEKFN-VE..V..G
  43 ICEIF.....KEEKNP.....DLIFL.KCTSAYP...TAIEDMNLKGIVSLKEKFN-VE..V..G
  44 TVETV.....RRAGND.....QLVLL.HCISSYP...APTEDANLATIPHMAQAFG-VP..V..G
  45 ICEIF.....KEEKNP.....DLVFL.KCTSTYP...TAIEDMNLKGIVSLKEKFN-VE..V..G
  46 SIHVL.....QDLGA-.....QYVLL.HCNSTYP...APFKDINLRYIEHLKKSGG-CL..V..G
  47 AIETL.....IESGCE.....KIVIM.HCVSQYP...SPINEMNLKVIEGLKSIYPEFV..I..G
  48 SIHVL.....QDLGA-.....QYVLL.HCNSTYP...APFKDINLRYIEHLKKSGG-CL..V..G
  49 SVEII.....REAGV-.....PYALL.HCTNIYP...TPYEDVRLGGMNDLSEAFPDAI..I..G
  50 SVNVL.....TKNGMApe...KITIL.HCNTEYP...TPYEDVNLNSIIGLKNEFKGYN..V..G
  51 TVKIL.....RDYEI-.....PFVLL.HTTNLYP...TPSHLVRLQAMLELYKEFN-CL..Y..G
  52 TVKIL.....RDYEI-.....PFVLL.HTTNLYP...TPSHLVRLQAMLELYKEFN-CL..Y..G
  53 AVAIF.....RELKT-.....DYVLM.HCTSLYP...TPYEKVRLGALGDLKKAFPDAV..L..G
  54 AVETV.....RAEGND.....QVVLL.HCVSIYP...PDYEMIHLRNMATLQQAFD-VP..V..G
  55 ALNVL.....INSGSSle...NITIL.HCTTEYP...APFHEVNLYAMETLKSAFR-AK..V..G
  56 ALNVL.....CKNGAKrq...NITLL.HCTTEYP...APFNEVNLKAMQSLKDAFK-LD..V..G
  57 AVDCF.....IDS---.....PVTIL.HCTSNYP...ASSEDINLLAINTLKEMFG-IP..V..G
  58 SVKVL.....RDNGCK.....ELVLL.KCTSTYP...ATPESTNIYTIPHMSTLFD-VP..V..G
  59 AVKAA.....RSAGCK.....DLALL.KCTSSYP...ASPHNTNIRTIPHLASLFS-CH..T..G
  60 SVDLL.....RRLGA-.....PFALL.HCNSTYP...APFKDVNLNYLPHLKQLGG-TV..V..G
  61 AVNAA.....RQVGCQ.....DLILL.KCTAAYP...AKSIDMHLRTIFHMSENFQ-VL..I..G
  62 AINVL.....VMAGTPra...QITLL.HCTTEYP...APLQEVNLRAMLSMGQSFA-LP..Y..G
  63 AVVTL.....RDAGLSld...MITVL.HATTDYP...TAPEDVNLLAMKTIEQAFPGII..V..G
  64 ALSVL.....EQAGTFrs...MITVL.HCTTEYP...APVEQVNLRAMNSISQAFD-VA..V..G
  65 ALDTA.....LSAGAP.....GVLLL.HCVSSYP...ATFADANVRTVPDMAARFG-CP..I..G
  66 AISLC.....RRVNNF.....DITLL.KCVSAYP...SKIEDANLLSMVKLGEIFG-VK..F..G
  67 SVSIF.....INNKVPvg...NITIL.HCNTEYP...TPFEDVNLNAINDLKKHFPKNN..I..G
  68 AISLC.....RGVNNF.....DITLL.KCVSAYP...SKIEDAHLLSMVKLGETFG-VK..F..G
  69 AAEFL.....DERKA-.....GYVLL.HCQSTYP...AALHNIHLRFMDTLREIHP--L..V..G
  70 GIRHL.....QQEGA-.....NYVLL.HCNSTYP...TPFKDVNLRYLERLKELAD-AP..V..G
  71 AIDTV.....KPYYGNslsd.YLVLL.HCTSNYP...ASYQDVNLKAMQTLADEFQ-LP..V..G
  72 ALGVLa25egRRKLSE.....KVTIL.HCTTDYP...AKLEEVNLNAMLTIKNAFG-LP..I..G
  73 ALEIC.....HKYGCK.....DITLL.HCISEYP...APLESANLLAMPQLAKTYKKYN..IkyG
  74 AVAAL.....RRGGVG.....PLALL.HCTSEYP...APDSQMNLRAMTTLGRAFG-LP..V..G
  75 ICEIF.....KEEKNP.....DLVFL.KCTSTYP...TAIEDMNLKGIVSLKEKFN-VE..V..G
  76 ALGVLa25agQAVLRE.....KVTIL.QCTTEYP...APFAQVNLKAMDTLGAAFG-LP..V..G
  77 IVQTM.....RESGKE.....DYALM.HCVSSYP...TDPKDCSLQLISVLRTRFPNVA..I..G
  78 ALGVIa26agQKALKE.....KVTIL.HCTTEYP...APMAEINLRSMDTLGRAFD-LA..A..G
  79 ALGVIa26egQKALKE.....KVTIL.HCTTEYP...APMAEINLKAMDTLGKAFD-LP..A..G
  80 GLAIVa25svRMQLQG.....HVSLL.HCTSQYP...TPPDEVNLLAMDTLRS-FG-LA..V..G
  81 ALGVLa25aaRATLAR.....HVSLL.HCTTEYP...CPIEDVNLAAMATMRSAFQ-LP..V..G
  82 IYTHF.....RHRK--.....DVALL.HCVSSYP...TPPGDIMLRMIPLLRAHFPELT..I..G
  83 TVEIL.....EKYKI-.....QYSLL.HCTNVYP...TPASLVRLGGMEELQRTFPNAV..I..G
  84 AMDIL.....KENQ--.....NIVLM.QCNTNYTastENFKYINLNVLKKYEEKYPNAI..L..G
  85 AVEIF.....DRS---.....KLILM.HSTSTYP...MPPEEANLRTIITLRERYG-VP..V..G
  86 AVSFL.....RSENKDl....PLALL.HCITSYP...APEKEYNVSVIKNLSRIFG-IA..C..G
  87 AVERY.....HSQGGR.....DLCLL.QCTAKYP...APLATVNSAVLPWLQRRYG-VS..V..G
  88 AVEVL.....---GSD.....NILLC.HATSTYP...AKAEELNLRVINTLQAEYPNVP..I..G
  89 AVEVL.....---GSD.....NILMC.HATSTYP...AQAEELNLRVINTLQQEYPNVP..I..G
  90 ALDVI.....TRYHS-.....NIAIL.HCVSQYP...THPNNLNLRTITYLKKHYNKFE..I..G
  91 AVSWI.....EEKGN-.....PLALL.HCVLNYP...TDDVNAGLGMIPVLRQHFPQHL..I..G
  92 AVRYI.....GSLDSSyitqgKLALL.QCSSAYP...CPDGDANLNVMHSLRQAFG-LP..V..G
  93 AVNEL.....---GRE.....NLLIA.HTNSTYP...CPVEELNLRMIHTLQQRYPDNP..I..G
  94 ALATL.....RESGAT.....DVTLL.HCISDYP...ARLEDMQLAEMPRLAARFG-VP..V..G
  95 AISFL.....EKEGTD.....KLCLL.HCVSIYP...TPPEKANLKVLETFKNLYT-FP..I..G
  96 AVETA.....KSAGCE.....KIIIE.HSPDGHP...ALPEAHNLRMLRTLNQCFS-LP..V..G
  97 ALAQC.....RQYTKQgs...SHALL.HCITAYP...APETEYNLALLPALATIFN-IN..V..G
  98 AVEML.....RTAGCR.....DLTLL.HCVSGYP...APPEECNLAAIETIRSRFG-CP..V..G
  99 AADVL.....RTAGCR.....DMTLL.HCTSGYP...APPEQCNLAAVETLRRQFG-CA..A..G
 100 ALNVL.....CKNGAKrq...NITLL.HCTTEYP...APFDEVNLKAMQSLKDAFK-LD..V..G
 101 ALKTL.....KENGAS.....DITLL.HCVSAYP...TPEHECNLAVLGSFRNRYQ-VK..V..G
 102 VVSFM.....LHRGK-.....DLTIM.HCVAEYP...TPDDHLHLARIKTLRQQYAGVR..I..G
 103 ALNIL.....TKNGMKee...DITIL.HCNTEYP...TPYEDVNLLSIPYLKEKFPKYK..I..G
 104 VVTFF.....EDRGRGk....DLIIY.SCTSGYP...VPFEDICLKEILRIRAKFEKRVkgI..G
 105 AAEYI.....MDGGNY.....QVMFCeRGIRTFEt..YTRNTLDLSMVPALQSLSHLPV..I..V
 106 AAEYI.....LNEGNK.....DVILCeRGIRTFEt..YTRNTLDLSAVPAIKKLSHLPI..I..V
 107 AAEYI.....LAEGNP.....HVILCeRGIRTFEt..ATRNTLDLAVVPLIREMSHLPV..M..V
 108 SAEYV.....MSEGNQ.....SVILCeRGIRTFEt..ATRNTLDLSAIPVLKQMTHLPV..I..A
 109 AAEYI.....IAQGND.....QIILCeRGIRTYEr..ATRNTLDISAVPILKKETHLPV..V..V
 110 AAEYI.....IAQGND.....QIILCeRGIRTYEr..ATRNTLDISAVPILKKETHLPV..V..V
 111 AAEYI.....IAQGND.....QIILCeRGIRTYEr..ATRNTLDISAVPILKKETHLPV..I..V
 112 AAEYI.....LAEGNG.....QVILCeRGIRTFEt..ATRNTLDLAVVPLIREMTHLPV..M..V
 113 AAEYI.....MAQGNS.....QIILCeRGIRTFEt..ATRNTLDLSAVPLVKELSHLPI..L..V
 114 SAEYV.....LSEGNQ.....SVILCeRGIRTFEt..ATRNTLDLSAIPVLKGMTHLPV..I..A
 115 AAEYI.....AQRGNL.....NIVLCeRGIRTFEt..ATRNTLDISAVPVAQRLSHLPV..I..V
 116 AAEYI.....AAGGND.....QIILMeRGIRTYDnk.YTRNTLDVSAIPVLQSLTHYPV..V..A
 117 AAEYI.....AQRGNL.....NIVLCeRGIRTFEt..ATRNTLDISAVPVAQRLSHLPV..I..V
 118 AAEYI.....MAEGNN.....NVVLCeRGIRTFEn..YTRNTLDLNSVAVIKEKYRLPV..I..V
 119 AAEYI.....LSEGNN.....EVILCeRGIRTYEk..WTRNTLDLSAVALAKQETHLPV..I..V
 120 SSRYI.....SMSGNN.....NIMLVeRGIRTFEn..STRFTLDVSAVPVLHEKVNYPV..I..I
 121 MVATA.....QDAGCR.....DLIVL.HCLSSYP...APIEQSNLLTIPDMRKKLG-VQ..I..G
 122 -----.....------.....-----.-CISAYP...LQPEDANLRVISEYQKLFPDIP..I..G
 123 -----.....------.....-----.-------...----------------------..-..-
 124 -----.....------.....-----.-------...----------------------..-..-
 125 -----.....------.....-----.-------...----------------------..-..-
 126 -----.....------.....-----.-------...----------------------..-..-


                 220       230       240            250       260      
                  |         |         |              |         |      
   1 FSDHSEH....PTEAPCAAVRLGAKLIEKHFTIDKNL....PGA.DHSFALNPDELKEMVDGIRK
   2 YSGHETG....-IAISVAAVALGAKVLERHITLDKTW....KGS.DHSASLEPGELAELVRSVRL
   3 YSGHETG....-IAISVAAVALGAKVLERHITLDKTW....KGS.DHSASLEPGELAELVRSVRL
   4 YSGHETG....-IAISVAAVALGTKVLERHITLDKTW....KGS.DHSASLEPGELAELVRSVRL
   5 YSGHETG....-IAISVAAVALGAKVLERHITLDKTW....KGS.DHSASLEPGELAELVRSVRL
   6 YSDHTLG....-ILAPVVSVALGADVIEKHFTLDKNM....EGP.DHALSADPEEFKEMVNNIRL
   7 YSGHETG....-IAISVAAVALGAKVLERHITLDKTW....KGS.DHLASLEPGELAELVRSVRL
   8 YSGHETG....-IAISVAAVALGAKVLERHITLDKTW....KGS.DHSASLEPGELAELVRSVRL
   9 YSGHETG....-IAISVAAVALGAKVLERHITLDKTW....KGS.DHSASLEPGELAELVRSVRL
  10 LSDHSLG....-SVSAVVAVAMGASIIEKHFCLSREI....KSP.DSSFSMEPDEFKKMVEDIRA
  11 YSDHSIG....-SEVPIAAAAMGAEVIEKHFTLDTNM....EGP.DHKASATPDILAALVKGVRI
  12 YSGHESG....-INITVGAVALGAKVVERHVTLDKSW....KGS.DHAASLEPEELAELVRSIRI
  13 YSDHSIG....-SEVPIAAAAIGAEVIEKHFTLDTNM....EGP.DHKASATPDILAALVKGVRI
  14 LSDHTLD....-NTTAIASVALGASIIEKHFTLNRNG....GGP.DDSFSLEPAELSALCRDSKT
  15 YSDHSIG....-SEVPIAAAAMGAEVIEKHFTLDTNM....EGP.DHKASATPDILAALVKGVRI
  16 YSDHSIG....-SEVPIAAAAMGAEVIEKHFTLDTNM....EGP.DHKASATPDILAALVKGVRI
  17 FSDHSEH....PTEAPCAAVRLGAKLIEKHFTIDKNL....PGA.DHSFALNPDELKEMVDGIRK
  18 LSDHTID....-NATAVAAVALGACLIEKHVTMDRNG....GGA.DDSFSLEPHELAALCKDAKT
  19 LSDHTLG....-TVASVAGVALGACVIEKHFTLSRAD....KGP.DSEFSLEPDELRRLCQDARD
  20 YSDHTKG....-IEASIAAVALGASVIEKHLTLDKNM....EGP.DHKSSLEPNEMKAMIRALRN
  21 LSDHTTD....-NLACLGAVALGACVLERHFTDSMHR....SGP.DIVCSMDTQALKELIIQSEQ
  22 LSDHTTD....-NLACLGAVALGACVLERHFTDSMDR....SGP.DIVCSMDTKALKELIMQSEQ
  23 LSDHTTD....-NLACLGAVALGACVLERHFTDSMHR....SGP.DIVCSMDTQALKELIIQSEQ
  24 LSDHTTD....-NLACLGAVALGACVLERHFTDSMHR....SGP.DIVCSMDTKALKELIIQSEQ
  25 LSDHTTD....-NLACLGAVALGACVLERHFTDSMHR....SGP.DIVCSMDTKALKELIIQSEQ
  26 LSDHTTD....-NLACLGAVALGACVLERHFTDSMHR....SGP.DIVCSMDTQALKELIIQSEQ
  27 YSDHSIG....-SEVPIAAAAMGAEVIEKHFTLDTNM....EVP.DHKASATPDILAALVKGFAL
  28 YSGHETG....-IAISVAAVAMGAKVVERHVTLDKTW....KGN.DHQASLEPSELTELVSSIRL
  29 YSDHTSG....-ICVPLAAAAMGACVIEKHFTLDKNL....TGP.DHMASLEPTELEEMVRGIRL
  30 LSDHTTD....-NLACLGAVVLGACVLERHFTDSMHR....SGP.DIVCSMDTKALKELIIQSEQ
  31 LSDHTMG....-YSVATAAVALGATVIEKHFTLKRSD....GGP.DSAFSMEPEEFSAMVKSIRE
  32 LSDHTTD....-NLACLGAVALRACVLERHFTDSMHR....SGP.DIVCSMDTQALKELIIQSEQ
  33 LSDHTLD....-NTTAIASVALGGSLIEKHFTLDRSG....GGP.DDSFSLEPQEFAALCRDAKT
  34 LSDHTID....-NATAVASVALGACLIEKHVTLDRSG....GGA.DDSFSLEPIELAQLCKDAKT
  35 LSDHTID....-NTTAITSVALGASIIEKHFTLNRDG....GGP.DDSFSLEPAELAALCRDSKT
  36 LSDHTMG....-IGVAVVSVALGATFIEKHFTLRRVD....GGV.DSAFSMEPEEMQQLVIESER
  37 YSDHTEG....-IAVPIAAAALGAEVIEKHLTVDRNL....PGP.DHRASLEPGEFKEMVVAIRQ
  38 YSGHESG....-VSITVAAVALGAKIIERHVTLDKTW....KGS.DHAASLEPSELAELVRSIRL
  39 YSDHTKG....-IHISLTAIALGASVIEKHFTLDKNM....SGP.DHKASLEPDELQELCTKIRE
  40 LSDHTLG....-LIAPIVAVSLGASVIEKHFILSRSL....GGP.DGAFSLEPSEFKEMVSSIHA
  41 LSDHSMG....-VGVSVAAVALGATVVEKHFTLDRSA....GGV.DASFSLEPAELASLVVETER
  42 LSDHSFG....-FLAPVMAVALGARVIEKHFMLDKSI....ESE.DSKFSLDFDEFKAMVDAVRQ
  43 LSDHSFG....-FLAPVMAVALGARVIEKHFMLDKSI....ESE.DSKFSLDFDEFKAMVDAVRQ
  44 LSDHTQG....-TAVAVAAVALGACVIEKHFTLRRAD....GGL.DSHFSLEPEELVQLVRDCRA
  45 LSDHSFG....-FLAPVMAVALGARVIEKHFMLDKSI....ESE.DSKFSLDFDEFKAMVDAVRQ
  46 YSGHERG....-YLVALAAVSLGAKVIEKHFTLDREM....EGN.DHKVSLLPGEFREMVDGIRQ
  47 FSDHSMG....-ITADLGAVALGARVIEKHFTLDKNT....DGP.DHWFSMDPEDMKSLVREVRN
  48 YSGHERG....-YLVALAAVSLGAKVIEKHFTLDREM....EGN.DHKVSLLPGEFREMVDGIRQ
  49 LSDHTLD....-NYACLGAVALGGSILERHFTDRMDR....PGP.DIVCSMNPDTFKELKQGAHA
  50 FSDHSPG....-YYAAIASVPYGITFIEKHFTLNKNF....EGP.DHKASVTPDELRLLCEGIRA
  51 LSDHTTN....-NLACIGAIALGASVLERHFTESMDR....KGP.DIVCSMDESTLKDLINQTQE
  52 LSDHTTN....-NLACIGAIALGASVLERHFTDTMDR....KGP.DIVCSMDESTLKDLINQTQE
  53 LSDHSLG....-NYTCYAAVALGASVLEKHFTCDKLW....PGP.DVPISVDPGELKRLVEGTRA
  54 FSDHTMG....-TAIPLAAIALGACVIEKHFTLDQDM....EGW.DHAISATPTDLRTIVEEGRN
  55 YSDHTVG....-IEVAIAAVALGATVIEKHFTLDKNL....PGP.DHKASLEPNELKTMVSSIRN
  56 YSDHTRG....-IHISLAAVALGACVIEKHFTLDKNM....SGP.DHKASLEPQELKMLCTQIRQ
  57 YSDHSLG....-YDVGICAVAMGAKVIEKHFTLDKEL....PGP.DHKASLDPQEFADFVKHIRN
  58 LSDHTMG....-IGVAIASVALGARIIEKHFTLSRAD....GGV.DSSFSLEPEELKNLVVETER
  59 LSDHTLG....-LGVSVASVPLGACIIEKHFCLSRED....GGV.DSAFSLEPSEFRDLVDNVER
  60 YSGHERG....-FSVPLAAVALGARIVEKHFTVDRSM....EGN.DHKVSLLPEEFAEMVRQIRN
  61 LSDHTLG....-IGASIASLAFGCCLIEKHLTLSRKE....GGV.DSVFSLEPEELKLLVNESKN
  62 YSDHTEG....-IAIAIAAAALGATVIEKHFTLDRQL....PGP.DHKASLEPAALGEMVQGIRQ
  63 YSDHTLG....-TEIPVAAVALGAKVIEKHFTLDKTM....SGP.DHKASLEPQELADMVTAIRN
  64 YSDHTSG....-ISVPIAAVAMGAVLIEKHLTLNRTL....PGP.DHKASLEPDQFAAMVQGIRT
  65 LSDHTPG....-TAASVAAVSLGACAVEKHFTLARAD....GGP.DAAFSLEPAEFKALVDDTKN
  66 LSDHTIG....-SLCPILATTLGASMIEKHFILNKSL....QTP.DSAFSMDFNGFKSMVEAIKQ
  67 FSDHSSG....-FYAAIAAVPYGITFIEKHFTLDKSM....SGP.DHLASIEPDELKHLCIGVRC
  68 LSDHTIG....-SLCPILATTLGASMIEKHFILNKSL....QTP.DSAFSMDFNGFKSMVGAIKQ
  69 YSGHERG....-TAVSTAAVALGAIVIERHITLDREM....EGP.DHAASLEPEEFKALVTGIRE
  70 YSGHERG....-IEVPIAAVAMGAAVIEKHITIDRGM....EGN.DHKVSLLPDEFAQMMQGIRR
  71 YSDHTLG....-ILVPTLAVGMGACVIEKHFTMDKSL....PGP.DHLASMDPEEMKNLVQSIRD
  72 YSDHTVG....-ISVAIAAVAMGATLIEKHFTLDRNL....PGP.DHRASLEPQELKNMVDGIRA
  73 LSDHTLG....-ALCPSIATSLGASMIEKHFILDSSL....GGV.DSAFSMNKDEFKAMVEQVRD
  74 LSDHSLG....-GEAALAAIALGAVIIEKHFTLDRSL....PGP.DHQASLDPQGLAAFVAAIRR
  75 LSDHSFG....-FLAPVMAVALGARVIEKHFMLDKSI....ESE.DSKFILDFDEFKAMVDAVRQ
  76 LSDHTPG....-YAIPIAAVARGATLIEKHFTLDRNL....PGP.DHMASLEPHELKAMVEGIRQ
  77 YSGHELG....-VIISQAAVLLGARIVERHFTLDKSQ....KGS.DHRCSLEPQELKALTTAITN
  78 YSDHSEG....-ITIPIAAVARGAVLIEKHFTLDKNM....EGP.DHKASLEPQELGAMVKAIRQ
  79 YSDHSEG....-ITIPIAAVARGAVLIEKHFTLDKNM....EGP.DHKASLEPDELTAMVKAIRQ
  80 YSDHTEG....-GLVPIAAVARGACIIEKHFTLDRSM....PGP.DHKASLEPGELAQMVAQIRM
  81 YSDHTDG....-FEISVAAVALGATVIEKHLTLDRNA....PGP.DHAASLEPGDFGRMVSAIRN
  82 YSGHELG....-IQHSVASVALGAKIVERHFTLDKAW....KGT.DHQASLNPAEFGRMVRCIRA
  83 LSDHTVN....-NNACLAATALGASVLERHFTDSKSR....KGP.DIVCSMDPKELEELIKGVAE
  84 LSDHTKG....-FATVLGAIALGAVVIEKHFTDDNDR....EGP.DHKFAMNPKTWREMVDASLE
  85 YSGHERG....-LQISLAAVTLGAVAVERHITLDRTM....WGS.DHAASLEPAGLQHLVRDIRV
  86 VSDHSLD....PILVPALTLAAGGFIIEKHICLSRKE....EGL.DDPVALEPDMFKKMCSALNS
  87 LSDHSRD....PITAPVAAVAQGARCIEKHYTLHNAL....PGP.DHSFAITADELTQMVRRIRE
  88 YSGHETG....-LQTTLAAVALGATFVERHITLDRAM....WGS.DQAASVEPQGLTRLVRDIRT
  89 YSGHETG....-LQTTLAAVALGATFVERHITLDRAM....WGS.DQAASVEPQGLTRLVRDIRT
  90 FSDHTIG....-ISAATAAVAMGAEIIEKHVTIDRHM....KGT.DQLGSLGPDGVNRMIRDIRI
  91 YSDHTLPr...DMKVLEVATLLGATILEKHFSHDKTL....PGN.DHYHAMDKDDLKVFRTNMER
  92 YSDHTTD....-SEAAYAAAVMGAQILELHFTDTREG....KSFrDHLVSITRDELRDLLKRIRR
  93 YSGHEVG....-LATTWAAVALGATFVERHVTLDRAM....WGS.DQAASVEISGMSRLVSNIRD
  94 LSDHSLG....-LEASRMALALGARVIERHFTTDPALmeriPDA.DHDISITPAQLRELRLAAER
  95 FSDHTTG....-NIAASVAVSLGACMIEKHFTLDKNL....DGP.DHVISANPEELKNVCESAFT
  96 LSDHYNG....-IEMLYMSIALGASILEKGVHLYPED....IDQ.DISHTMGIDQLAKTLETIYN
  97 VSDHSVD....PLLVPLLARAHGACIVEKHICLSRTD....AGL.DDSIALDPADFRTMTAALNS
  98 WSDHSVS....PAVIQRAVHQWEASAVEFHLDLEGEG....EEF.ATGHCWLPDGIKAVIADVST
  99 WSDHTVH....AGVIHRAVHRWGAQVVEFHLDLDGDG....AEY.ASGHCWLPHQIAPVISQIRQ
 100 YSDHTQG....-IHISLAAVALGACVIEKHFTLDKNM....SGP.DHKASLEPHELKTLCTQIRQ
 101 WSDHTVS....SAVINRAVHRWEADVVEFHLDLDETG....DEY.AAGHCWLPQQIATVIQGVKL
 102 YSTHEDPd...LMEPIMLAVAQGATVFEKHVGLPTDQ....YGI.NN-YSANPEQVRRWLAAAAR
 103 FSDHSQG....-YFDGVAAVPYGITFIEKHFTLDKK-....---.--------------------
 104 FSGHHLG....-IAADIAALAYGAKYFERHFTLDRTW....KGT.DHAASLEPDGMRRLARDLRN
 105 DPSHGTGrwnlVPPMAKAAVAAGADGIIVEVHPQPEK....AVS.DGKQSLTPDNFASMMAELEI
 106 DPSHGTGrwhlVPSMAKAAVAAGADGLIIEVHPDPKN....ALS.DGPQSLTPDNFESLVKELKI
 107 DPSHATGkrslVAPMAKAALVAGAHGVLIEVHPEPDK....ALS.DGPQSLTFHGFDLLMEEIRR
 108 DPSHGTGnyhyVAPMALAAVAAGADGLMIEVHPDPER....ASS.DGPQSLKPKKFDALMAKLRL
 109 DVTHSTGrrdlLLPTAKAALAIGADAVMAEVHPDPAV....ALS.DSAQQMDIPEFHRFMEEL--
 110 DVTHSTGrrdlLLPTAKAALAIGADAVMAEVHPDPAV....ALS.DSAQQMDIPEFHKFMEEL--
 111 DVTHSTGrrdlLLPTAKAALAIGADAVMAEVHPDPAV....ALS.DSAQQMDIPEFHRFMDEL--
 112 DPSHATGkrslVAPMAKAALVAGAHGVLVEVHPEPDK....ALS.DGPQSLTFHGFEALMGEIRR
 113 DPSHSTGasrlVASMSRAAVAAGADGLLVEVHPEPCK....ALC.DGPQSLEPEDFTRMVESLRP
 114 DPSHGTGnyhyVAPMALAAVAAGADGLMIEVHPDPER....ASS.DGPQSLKPKKFDALMTKLRL
 115 DPSHSGGrrdlVVPLTRAAIAVGADGLLIDVHPEPKT....ALC.DGDQALPEADIREIADIVAS
 116 DASHAAGvskfVEPLALAAIAAGAQGLMTEIHDDPSH....AFV.DGAQALTPAQFKQLTEKANK
 117 DPSHSGGrrdlVVPLTRAAIAVGADGLLIDVHPEPKT....ALC.DGDQALPEADIREIADIVAS
 118 DPSHGTGirqiVPIMSMAAIAAGADGIMVESHINPEH....SIS.DSKETVSLEVIGNIVENIR-
 119 DVTHAAGrrdlLIPLAKAAIAVGADGIHVEVHPNPAT....ALS.DNEQQLDFAGYEKFLEGVGS
 120 DPSHPAGnsryVEPLALAGIAAGADGIIVEVHPDPSR....ALS.DAAQQLNLDQFSRLYSKIKE
 121 LSDHTIS....-NTASVVATGLGATLIEKHFILDRND....KGP.DSSFSIEPNELTSLIEQTND
 122 YSGHETG....-IAISVATVALGATVLEHHITLDKTW....KGS.ENLASLEPGELAELVRSVRL
 123 -------....----------LGASMIEKHFILNKSL....QTP.DSAFSMDFNEFKSMVGAIKQ
 124 -------....-----------GASMIEKHFILNKSL....QTP.DSAFSMDFNGFKSMVGAIKQ
 125 -------....---------ALGASIIEKHFTLDRNA....GGP.DDSFSLEPTDLTALCRDSKT
 126 -------....------------------------NL....EGP.DHKASVLPEELKLLCEGIRA


       270       280                      290       300       310      
        |         |                        |         |         |      
   1 TEAELKQGITKPVSE.....K.....LLGSSY.....KTTTAIEGEIRNFAYRGIFTTAPIQKGE
   2 VERALGSPTKQL---.....-.....------.....---LPCEMACNEKLGKSVVAKVKIPEGT
   3 VERALGSPTKQL---.....-.....------.....---LPCEMACNEKLGKSVVAKVKIPEGT
   4 VERALGSPTKQL---.....-.....------.....---LPCEMACNEKLGKSVVAKVKIPEGT
   5 VERALGSPTKQL---.....-.....------.....---LPCEMACNEKLGKSVVAKVKIPEGT
   6 VEKMLGSGEKIP---.....-.....------.....---MPSERDVIVEARRSIVAKRNIKKGE
   7 VERALGSPAKQL---.....-.....------.....---LPCEMACNEKLGKSVVAKVKIPAGT
   8 VERALGSPTKQL---.....-.....------.....---LPCEMACNEKLGKSVVAKVKIPAGT
   9 VERALGSPTKQL---.....-.....------.....---LPCEMACNEKLGKSVVAKVKIPAGT
  10 AEKSIGKVSYSI---.....-.....------.....----SENEAVSRSHRRSIFVVKDIKKGE
  11 VEQALGRFEKIP---.....-.....------.....---DPVEEKNKIVARKSVVALKPIKKGD
  12 VERALGTGLKRM---.....-.....------.....---LPCEVPCHDKLGKSVVAKTSIPKGT
  13 VEQALGRFEKIP---.....-.....------.....---DPVEEKNKIVARKSVVALKPIKKGD
  14 AWASLGIVDYGR---.....-.....------.....----KSSEAGNVKFRRSLYAIRDIEAGE
  15 VEQALGRFEKIP---.....-.....------.....---DPVEEKNKIVARKSVVALKPIKKGD
  16 VEQALGRFEKIP---.....-.....------.....---DPVEEKNKIVARKSVVALKPIKKGD
  17 TEAELKQGITKPVSE.....K.....LLGSSY.....KTTTAIEGEIRNFAYRGIFTTAPIQKGE
  18 AWSALGSVNYTR---.....-.....------.....----TEAEKGNVKFRRSLYVIRDIKAGD
  19 AWSALGSLGFER---.....-.....------.....----QQAEEASKVFRRSVYFVRDVSAGT
  20 IELALGDGIKKP---.....-.....------.....---SESEKKNICVARKSIVAKRYIQKGE
  21 MAIMRGNNESKK---.....-.....------.....--AAKQEQVTIDFAFASVVSIKDIKKGE
  22 MAIMRGNNESKK---.....-.....------.....--AAKQEQVTIDFAFASVVSIKDIKKGE
  23 MAIMRGNNESKK---.....-.....------.....--AAKQEQVTIDFAFASVVSIKDIKKGE
  24 MAIMKGNNESKK---.....-.....------.....--AAKQEQVTIDFAFASVVSIKDIKKGE
  25 MAIMKGNNESKK---.....-.....------.....--AAKQEQVTIDFAFASVVSIKDIKKGE
  26 MAIMRGNNESKK---.....-.....------.....--AAKQEQVTIDFAFASVVSIKDIKKGE
  27 LNQALGRFEKIP---.....-.....------.....---DPVEEKNKIVARKSVVALKPIKKGD
  28 VEKAMGSTVKSL---.....-.....------.....---LPCELACHNKLGKSVVAKVKIPAGT
  29 VEKARGSSVKAP---.....-.....------.....---VESELEVRDIVRRSIVAKVNIPAGT
  30 MAIIRGNNESKK---.....-.....------.....--AAKQEQVTIDFAFASVVSIKDIKKGE
  31 VEKALGKVTYEL---.....-.....------.....----TEKQKNSRQHSRSLFVVKDIKKGE
  32 MAIMRGNNESKK---.....-.....------.....--AAKQEQVTIDFAFASVVSIKDIKKGE
  33 AWEALGNVDYGH---.....-.....------.....----KSSETGNVKFRRSLYFVKFLKAGD
  34 AWQSLGKVNYER---.....-.....------.....----TEAEKGNVKFRRSLYVVKDIAEGE
  35 AWSALGKIDYGR---.....-.....------.....----KSSEIGNVKFRRSLYFVKDMRKGQ
  36 AWQALGNIKYGA---.....-.....------.....----TEAEKESLVFRRSLYIAKDMKAGD
  37 VEKSLGDGIKRP---.....-.....------.....---APGELAVMPAARRSLVAARDIAAGE
  38 VERALGNGVKRM---.....-.....------.....---LPCEKPCHDKLGKSVVAKVRIPKGT
  39 IESALGDGIKQA---.....-.....------.....---SKSERKNIEIARKSLVAKKKIKKGE
  40 ASLALGEANYEL---.....-.....------.....----SPKVAKSKIFKRSLFVCEKIQKGE
  41 AWQAMGQVHYGV---.....-.....------.....----TEAEQKSLVYRRSLYVTTDMAAGE
  42 AESALGDGKLDL---.....-.....------.....----DEKVLKNRVFARSLYASKDIKKGE
  43 AESALGDGKLDL---.....-.....------.....----DEKALKNRVFARSLYASKDIKKGE
  44 AWTARGRISYAL---.....-.....------.....----AECEQGSKGFRRSLYVVEDLHPGE
  45 AESALGDGKLDL---.....-.....------.....----DEKALKNRVFARSLYASKDIKKGE
  46 IEESLGNKNFRQ---.....-.....------.....--ITQGELMNRETLGKSLLINRDLKLGE
  47 LEAAMGHPRKRV---.....-.....------.....---LKCEEQGRKNSIRSLVVNRDIMKGE
  48 IEESLGNKNFRQ---.....-.....------.....--ITQGELMNRETLGKSLLINRDLKLGE
  49 LKLARGGKKDTI---.....-.....------.....---IAGEKPTKDFAFASVVADKDIKKGE
  50 VEKCLGSYAKIV---.....-.....------.....---TKSEQKNKIVARKSIVAKCNIKKGE
  51 MVLLRGDNNKNP---.....-.....------.....---LKEEQVTIDFAFASVVSIKDIKKGE
  52 MVLLRGDNNKNP---.....-.....------.....---LKEEQVTIDFAFASVVSIKDIKKGE
  53 VHQAMGGHKEI----.....-.....------.....---LPDEKPTIDFAYASVVAIRDIRAGD
  54 IRIALGGGKRIV---.....-.....------.....---TEAEMEKRKKFRRSLVTRRALPQGH
  55 IEKSMGDGIKKP---.....-.....------.....---SSSERKNIPIARKSIVATRNISKGE
  56 IQKAMGDGIKKA---.....-.....------.....---SKSEQKNINIVRKSLVAKKDIKKGE
  57 TEIFLGDGVKRA---.....-.....------.....---MPSELSTKEVSRKSLVVTENLNVGD
  58 AFLSLGKVNYIL---.....-.....------.....----SEKEKKSLQFKRSLYVVKDIKKGE
  59 AWQSLGSIHYGP---.....-.....------.....----TDSEIKSLCFRRSIFISEDVSQGQ
  60 IEEALGQGGERS---.....-.....------.....--LTQGEMINRENLAKSLVINCDLSQGQ
  61 AWEALGQIHYGP---.....-.....------.....----LAVEQTTHSHRPSLYFVEDLEQGE
  62 VEQAMGDGIKRP---.....-.....------.....---TPTELANRPIARKSIVARCAIRAGE
  63 IEQALGNGWKVP---.....-.....------.....---TKTEQENRNIVRKSLVAGKPIMAGS
  64 IEQALGDGIKRP---.....-.....------.....---TPSEQSNLPVVRKSLVAACPIRAGE
  65 AWAALGRAHYDV---.....-.....------.....----LGSEATSLLFRRSLYVTADVKAGE
  66 SVLALGEEEPRI---.....-.....------.....---NPKTLEKRRFFARSLFVIKDIQKGE
  67 VEKSLGSNSKVV---.....-.....------.....---TASERKNKIVARKSIIAKTEIKKGE
  68 SVLALGEEEPKI---.....-.....------.....---NPKTLEERRFFARSLFVIKDIQKGE
  69 VEAARGEKLAER---.....-.....------.....-ALSQGELINRENLAKSLVAARDIEAGT
  70 VEESMGQGGERS---.....-.....------.....--ISQGEMMNREVLAKSLVAACDVPAGT
  71 AETVLGSGEKKP---.....-.....------.....---SDNELPIRALVRRSITLRRDLVKGA
  72 VEKAKGSFVKGP---.....-.....------.....---TPAEVLNRAVVRRSLVAKAEIQVNE
  73 TALALGCKKPKI---.....-.....------.....---SADIRKKRRQFARSIWVSADIKKGE
  74 VEAMLGDQIKRP---.....-.....------.....---TATELANMNGIRRGVVAARNLAAGT
  75 AESALGDGKLDL---.....-.....------.....----DEKVLKNRVFARSLYASKDIKKGE
  76 VTVAIGDGCKRP---.....-.....------.....---SADEIGNRTIARRSLVAATAVKRGE
  77 FKLSSVPMPPQEIVK.....K.....LNGDEEl10esKTILPCELPCRNKLGKSIVAARNLNKGY
  78 IEVALGSSVKTP---.....-.....------.....---TESEVKNKAVARKSLVAATDIKEGE
  79 VELALGSAVKSP---.....-.....------.....---TVSEVKNKAVARKSLVASQAIQAGD
  80 LEVALGSPYKAP---.....-.....------.....---QPSEWDTRQAARQQVVAARDIEAGM
  81 VEAALGDGVKTP---.....-.....------.....---KESEVRNVPVARKSIVAARALRAGE
  82 IE------------N.....D.....EIDPHH.....RQLLECERPCYNKLGKSLVYASDLNCGT
  83 VAKMRGGKKEAA---.....-.....------.....----KEEKITIDFAFSTVVTIEDLRAGE
  84 LYYSLGDGIKRI---.....-.....------.....---EKNEEDTAMVQRRGIYITKSLKAGH
  85 IEQALGDGVKRV---.....-.....------.....---FPGEEEPRKRLRR------------
  86 FSKKTYDEIIEGLTKln9inE.....VIGSGE.....KKLSPAETKNYGRTNRSIHYLNDLKKGD
  87 AEEVRGDGIKQV---.....-.....------.....---QPQEQELAAFARRGVQALQDIAPGE
  88 IEASLGDGVKKV---.....-.....------.....---YESELGPMKKLRR------------
  89 IEASLGDGVKKV---.....-.....------.....---YDSELGPMKKLRR------------
  90 AECWLGTEDLYI---.....-.....------.....---EKGVEKSKIKLERSIATRKYIPAGS
  91 VTGMVGPCNITS---.....-.....------.....---LPSEEPARRNARRSLVAARAIPAGK
  92 ARTLQGSWVKQP---.....-.....------.....-TDTEKAQGHVTSFRRSVYAAQDIAAGQ
  93 IEKALGDGVKRV---.....-.....------.....---YDGEAAARKKLR-------------
  94 TALALGGAERVL---.....-.....------.....---APQESAGRTASRRGLYARTRLAAGH
  95 SWKMKGNGEKKP---.....-.....------.....---WPEEINGRFFGRRSLYA--------
  96 CWQALGQPMRDL---.....-.....------.....--ETPIKGVLGSSQRTCLVAKQKLQPGS
  97 CARRSPSQIISFLHE.....Rgy9raVIGSGE.....KVLAPSERAHYQKSNRSLHYLHAYPRGT
  98 ALSADGTGEKVP---.....-.....------.....---TPVEFPDRE----------------
  99 AFSADGNGVKEP---.....-.....------.....---APCEEQERN----------------
 100 IQKAMGDGIKKA---.....-.....------.....---SKSEQKNINIVRKSLVAKKDIQKGE
 101 ATVIDGSPVKQF---.....-.....------.....---VASEASDRE----------------
 102 ALAMLGDGEDDA---.....-.....------.....--VSETEQASLRSLRRGVFATRPVAAGE
 103 ---------------.....-.....------.....----------------------------
 104 VSKALTYKQKEI---.....-.....------.....---LDIEEIQRNK---------------
 105 LAQALGRPVK-----.....-.....------.....----------------------------
 106 IAEAVG---------.....-.....------.....----------------------------
 107 LNAFLG---------.....-.....------.....----------------------------
 108 VAA------------.....-.....------.....----------------------------
 109 ---------------.....-.....------.....----------------------------
 110 ---------------.....-.....------.....----------------------------
 111 ---------------.....-.....------.....----------------------------
 112 LNEFL----------.....-.....------.....----------------------------
 113 IAAAVG---------.....-.....------.....----------------------------
 114 VAE------------.....-.....------.....----------------------------
 115 LPAFLGR--------.....-.....------.....----------------------------
 116 V--------------.....-.....------.....----------------------------
 117 LPAFLGR--------.....-.....------.....----------------------------
 118 ---------------.....-.....------.....----------------------------
 119 ---------------.....-.....------.....----------------------------
 120 ISRIM----------.....-.....------.....----------------------------
 121 AWLSLGQAGYER---.....-.....------.....----KPAEEANIKFRRSVYFVKDLPAGS
 122 VEWALGSPTKQL---.....-.....------.....---LPCEMACNEKLGKSVVAQVKIPAGT
 123 SVLALGEEEPKI---.....-.....------.....---NPKTLEERRFFARSLFVIKDIQKGE
 124 SVLALGEEEPKI---.....-.....------.....---NPKTLEERRFFARSLFVIKDIQKGE
 125 TWAALGKVDYGR---.....-.....------.....----KASEQGNMKFRRSLYFVKDLKAGD
 126 VEKSMGKYKKIV---.....-.....------.....---TNSERKNKIVARKSIIAKVKIKKGE


       320        330        340       350       360       370   
        |          |          |         |         |         |   
   1 AFSED.NIAVLRPGQK.PQGLHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE
   2 ILTMD.MLTVKVGE--.PKGYPPEDIFNL-VGKKVLVTVEEDDTIMEELVDNHGKKIK-
   3 ILTMD.MLTVKVGE--.PKGYPPEDIFNL-VGKKVLVTVEEDDTIMEELVDNHGKKIK-
   4 ILTMD.MLTVKVGE--.PKGYPPEDIFNL-VGKKVLVTVEEDDTIMEELVDNHGKKIK-
   5 ILTMD.MLTVKVGE--.PKAYPPEDIFNL-VGKKVLVTVEEDDTIMEELVDNHGKKIK-
   6 YLSVD.NISFKRPG--.-RGIETKYLSII-LNRKIKNDKEEDDIIYWDDL---------
   7 ILTLD.MLTVKVGE--.PKGYPPEDIFNL-VGKKVLVTIEEDDTVMEESVESQSKKI--
   8 TLTLD.MLTVKVGE--.PKGYPPEDIFNL-AGKKVLVTIEEDDTVMEESVESHSKKI--
   9 TLTLD.TLTVKVGE--.PKGYPPEDIFNL-AGKKVLVTIEEDDTVMEESVESHSKKI--
  10 AFTEE.NIRIIRPA--.-DGLEPKYFEQV-LNRRASQDIERGTPLKWTM----------
  11 IYSIE.NITVKRPG--.-NGISPMNWYDI-LGQEAQDDFEEDEVIRDSRF---------
  12 ELTLD.MLAVKVAE--.PKGVAPEEIFQL-VGKKVTTDVEEDESITEDVVDSYG-----
  13 IYSIE.NITVKRPG--.-NGISPMNWYDI-LGQEAQDDFEEDEVIRDSRF---------
  14 PLTAE.NIRSVRPG--.-YGLSPKHYTEV-LGKTAAVKIPAHTPIHWEK----------
  15 IYSIE.NITVKRPG--.-NGISPMNWYDI-LGQEAQDDFEEDEVIRDSRFE--------
  16 IYSIE.NITVKRPG--.-NGISPMNWYDI-LGQEAQDDFEEDEVIRDSRFE--------
  17 AFSED.NIAVLRPGQK.PQGLHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPF--
  18 VLSND.NVRSIRPG--.-FGLAPKYLEQV-LGKTAIVDIKRGTPLSFE-----------
  19 VIGAE.HIRRIRPG--.-MGLEPKYFDQL-IGRRVNQDVSRGTPVKWTHF---------
  20 IFTEE.NLTVKRPG--.-NGISPMQWFEV-LGRRAVRDFQEDEL---------------
  21 VLSMD.NIWVKRPG--.LGGISASEFENI-LGKKALRDIENDTQLSYEDF---------
  22 VLSMD.NIWVKRPG--.LGGISAVEFENI-LGKKALRDIENDTQLSYEDF---------
  23 VLSMD.NIWVKRPG--.LGGISASEFENI-LGKKALRDIENDTQLSYEDF---------
  24 VLSMD.NIWVKRPG--.LGGISAAEFENI-LGKKALRDIENDTQLSYEDF---------
  25 VLSMD.NIWVKRPG--.LGGISAAEFENI-LGKKALRDIENDTQLSYEDF---------
  26 VLSMD.NIWVKRPG--.LGGISAAEFENI-LGKKALRDIENDTQLSYEDF---------
  27 IYSIE.NITVKRPG--.-NGISPMNWYDI-LGQEAQDDFEEDEVIRDSRFE--------
  28 VLTLN.MLTVKVAE--.PRGFPPEEIYDL-EGKTVKREIPEDESVTEEAIENY------
  29 VIAED.LLAFKRPG--.-VGMPPKYLDRL-IGKVPISEIKKDSLINFEMF---------
  30 VLSMD.NIWVKRPG--.LGGISAAEFENI-LGKKALRDIENDAQLSYEDF---------
  31 TFTKE.NVKSIRPA--.-FGLKTKYIEEV-IGKKARVDVKKGTPLDWNL----------
  32 VLSMD.NIWVKRPG--.LGGISAAEFENI-LGKKALRDIENDTQLSYEDF---------
  33 IVTPD.AVRSVRPG--.-FGLAPKFLDRV-LGKILRKDVQINTPVTED-----------
  34 EFTSE.NVKSIRPG--.-FGLPPKNLINI-LGKRANMKIKFGTPLSE------------
  35 LITQD.SIRSVRPG--.-FGVAPKYLESI-VGRTVSDDVRSGTAVSWDLI---------
  36 IFTSE.NLRAVRPG--.-LGLSPKYYDTI-LGKKIKQDAKIGTPISWN-----------
  37 IITDS.CLTAKRPG--.-TGIPPNLWDVV-VGRQARRDIAAGSILSWDM----------
  38 VLTAD.MLAVKVAE--.PMGVKAEEIFEL-VGKTVMENVEEDESVV-------------
  39 IFSEE.NLTTKRPA--.-SGISAMRYDEY-LGKKASKDYEEDELI--------------
  40 RFTPK.NLRSIRPG--.-HGLPPKHLNEI-LGKEAACDIERGEPLTWEM----------
  41 PFTAA.NLRAIRPG--.-LGLPPKHTDAV-LGRRARQPIKRGTPLDWS-----------
  42 MFSEE.NVKSVRPS--.-FGLHPKFYQEL-LGKKASKDIKFGDALKQGDF---------
  43 IFSEE.NVKSVRPS--.-FGLHPKFYQEL-LGKKASKDIEFGDALKESDF---------
  44 TITED.KVRSIRPG--.-YGLEPKFLPEI-LGRKARKAVPRGTAFDWSM----------
  45 MFSEE.NVKSVRPS--.-FGLHPKFYQEL-LGKKASKDIEFGDALKQGDF---------
  46 IITSD.MVDIRSPG--.-KGLPPYFKEKL-IGKSAKRDFKKGDFFYKSDIA--------
  47 VIKKE.DLVALRPG--.-YGIKPYDKEKI-IGLKIKKELKSGTVLTWDC----------
  48 IITSD.MVDIRSPG--.-KGLPPYFKEKL-IGKSAKRDFKKGDFFYKSDIA--------
  49 LLSGD.NLWVKRPG--.-NGDFSVNEYETLFGKVAACNIRKGAQIKKTD----------
  50 IYTID.NITTKRPG--.-NGISPMYWYDI-LGKKAEKNFDEDQLISHSGF---------
  51 ILSMD.NIWVKRPS--.KGGISAKDFEAI-LGKRAKKDIKNNIQLTWDDF---------
  52 ILSMD.NIWVKRPS--.KGGISAKDFEAI-LGKRAKKDIKNNIQLTWDDF---------
  53 ILSKD.NIWVKRPG--.-TGEILARDYERVLGRVAKRPLQKNAQLAWDDF---------
  54 VLVEA.DLDAKRPG--.-TGISPAEMTYA-LGRRLARDMQEDDVIRWED----------
  55 IFSES.NITTKRPG--.-DGLSPMNWDMV-IGKQARRDFQIDEL---------------
  56 IFSEG.NLTTKRPA--.-NGISAMRYEEF-LGKIATKNYKEDELI--------------
  57 ILTEK.SLTIKRPG--.-NGIAPKFLYQY-IGKKVKRPISADSVLLEED----------
  58 AFTAL.NVRSIRPC--.-NGLHTRYYDSV-LTKQANQDIKAGTPLSLDD----------
  59 ILDES.NLKIVRPN--.-SGLHPRFYEIV-LGRRAARSLSKGTPLSFDM----------
  60 LIRRS.MITVKSPG--.-QGLQPNRIDEL-AGKVAQRDFKAGDFFFETDIT--------
  61 KIQLH.HIRSVRPN--.-KGLPPKEIDKI-IGLTINQSIAKGTPVTWDLF---------
  62 PLTAE.NLTTKRPG--.-DGLSPMYWDEL-VGRPAQRDYAEDDPI--------------
  63 IICAD.MLEIKRPG--.-NGISPTRWDEV-VGSIAKKDYQIGE----------------
  64 IFSEN.NLTAKRPG--.-TGISPIHWDAW-IGRKASRDFAEDEM---------------
  65 PLTRA.NVRSVRPG--.-NGLPPADLDKV-LAGKATRDLARGEPLDWSM----------
  66 ALTEN.NIKALRPN--.-LGLHPKFYKEI-LGQKASKFLKANTPLSADDI---------
  67 VFSEK.NITTKRPG--.-NGISPMEWYNL-LGKIAEQDFIPDELIIHSEFKN-------
  68 ALTSD.NIKALRPN--.-LGLHPKFYKEI-LGQKASKFLKANTPLSADDI---------
  69 VISDD.DIAVKSPG--.-QGLSPLKMPAL-IGKILKRKMAADDYFFQSDLD--------
  70 EITEA.MVRIQSPG--.-QGLQPNRLNDL-IGRRLPVAKAQGEVFFPSDL---------
  71 QISKE.DLILLRPG--.-TGIAPSEISNI-VGSRLSMNLSAGTNF--------------
  72 RFSEN.NLDAKRPG--.-TGVSPMLFWEY-LSKSSSKAYAVDD----------------
  73 KFTHK.NLSVVRPS--.-GGEHPRYLHKI-LGKSAKVALKAAQPLRLSD----------
  74 ILDTT.MLVCKRPG--.-GGIEPEDLDRL-AGFTLRRDLAEDEPLSWDD----------
  75 MFNEE.NVKSVRPS--.-FGLHPIFYLEL-LGKK-------------------------
  76 IWTES.NLTCKRPG--.-DGVSPYRFWDF-IGKPATRDYRADEKL--------------
  77 RLQLA.DMAIKVSE--.PSGLTAEDFLDL-VGKELADNIGEDEPILGN-----------
  78 ELTEL.NLTIKRPG--.-SGLSPYRYWEL-IGSKATKGYKAGELI--------------
  79 AFSAD.NVTIKRPG--.-NGMSPYQYWEM-LERKASRDYQIGDLI--------------
  80 IITRD.DLTTARSG--.-HGLPPTSLWEL-VGSTSKRAFLAGE----------------
  81 IIGPA.DITAKRPG--.-AGRPPIDYWSL-IGTAAPRALEPDD----------------
  82 VLTES.NVQVKVSE--.PKGLSPRLYDSV-VGRTVKCAVFKDDPI--------------
  83 LITKD.NIWVKRPG--.-TGEIKAEHFNSLLGKKVTRDIPRDEHLMWNDI---------
  84 ILSRE.DLIALRPI-K.IDGIQPYEIDLL-LGKKLTKNIESDSYLTWKD----------
  85 -----.----------.------------------------------------------
  86 VITDK.DIAVLRTEKIlSPGEAPEMFDSF-IGAVLQRAVKSGEGLLMEDF---------
  87 ALLEGhNIAILRPGQQ.PLGVHPRLLEQM-QGRIAQRAIPAGQGVQLG-----------
  88 -----.----------.------------------------------------------
  89 -----.----------.------------------------------------------
  90 IIQES.DIHLLSPG--.-DGYKWIDKKNV-IGHFAKQDISANEIIYPDF----------
  91 VLEPA.DLTWKRPA--.-HGISPRCYDEV-VGMKARADIAEDTVLKWG-----------
  92 LFTED.NLTVLRPA--.-HGVCATRYEDF-LGRRAPRSMGAHEVLTAAD----------
  93 -----.----------.------------------------------------------
  94 ILRAE.DVTALRPV--.-AALPASALDAV-LGRPCPCDLAPLAPIPASMLPSHEEAV--
  95 -----.----------.------------------------------------------
  96 LISLD.NTTFAFPC--.-KGVPTQYWDLV-NGWELQNKVSIGEPIKWSDIKQKN-----
  97 VLQKE.NLVIVRSEANlSAGEAPEHANLF-VGAVLQRSVHAGEGARFGDIIQKG-----
  98 -----.--WRADPS--.-DGLRP------------------------------------
  99 -----.--WRADPQ--.-DGLRPL-----------------------------------
 100 IFSEE.NLTTKRPA--.-NGISAMRYEEF-LGKIATKNYKEDELI--------------
 101 -----.--WRADPQ--.-DGLRPMKS---------------------------------
 102 ALTAD.NVSFAFPP--.VEGQLTANEWSKYVRYTAKTPIAADAPVMAADL---------
 103 -----.----------.------------------------------------------
 104 -----.----------.------------------------------------------
 105 -----.----------.------------------------------------------
 106 -----.----------.------------------------------------------
 107 -----.----------.------------------------------------------
 108 -----.----------.------------------------------------------
 109 -----.----------.------------------------------------------
 110 -----.----------.------------------------------------------
 111 -----.----------.------------------------------------------
 112 -----.----------.------------------------------------------
 113 -----.----------.------------------------------------------
 114 -----.----------.------------------------------------------
 115 -----.----------.------------------------------------------
 116 -----.----------.------------------------------------------
 117 -----.----------.------------------------------------------
 118 -----.----------.------------------------------------------
 119 -----.----------.------------------------------------------
 120 -----.----------.------------------------------------------
 121 LVTAD.SIRRIRPG--.-LGLAPKHEQEI-IGKRLKTSVTRGTPTSWDLF---------
 122 ILTLD.ILTVKVGE--.PKGYPPEDIFNL-VGKMVLVTIEEDDTVLEESVQSQSKKI--
 123 ALTSD.NIKALRPN--.-LGLHPKFYKEI-LGQKASKFLKANTPLNADDI---------
 124 ALTEN.NIKALRPN--.-LGLHPKFYKEI-LGQKASKFLKANTPLSADDI---------
 125 VITED.AVRSVRPG--.-FGLAPKFLEEV-IGKVVKEDVKENTAVVL------------
 126 IFTEE.NLTTKRPG--.-NGISPMNWYKI-LGKKAEKDFDIDELIEDSNFKN-------