a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0222 spsE, Bacillus subtilis
- gi|13022171|gb|AAK11670.1|_247:334 putative N-acetyl neuramic acid synthetase NeuB [Streptococcus agalactiae]
- gi|22537319|ref|NP_688170.1|_247:334 N-acetyl neuramic acid synthetase NeuB [Streptococcus agalactiae 2603V/R]
- gi|11281338|pir||T44651 capsular polysaccharide biosynthesis protein cpsN [imported] - Streptococcus agalactiae [Taxonomy]
- gi|5823220|gb|AAD53074.1| NeuB [Streptococcus agalactiae]
- gi|13549139|gb|AAK29661.1| NeuB [Streptococcus agalactiae]
- gi|22534190|gb|AAN00043.1| N-acetyl neuramic acid synthetase NeuB [Streptococcus agalactiae 2603V/R]
- gi|25011285|ref|NP_735680.1|_247:334 Unknown [Streptococcus agalactiae NEM316]
- gi|3721923|dbj|BAA33753.1| neuB [Streptococcus agalactiae]
- gi|5381190|dbj|BAA82287.1| NeuB [Streptococcus agalactiae]
- gi|23095709|emb|CAD46895.1| Unknown [Streptococcus agalactiae NEM316]
- gi|13876783|gb|AAK43615.1|_247:334 putative N-acetyl neuramic acid synthetase NeuB [Streptococcus agalactiae]
- gi|14517803|gb|AAK64368.1|_254:341 NnaB [Escherichia coli]
- gi|12697602|dbj|BAB21605.1|_247:334 NeuB [Streptococcus agalactiae]
- gi|48860247|ref|ZP_00314173.1|_246:328 COG2089: Sialic acid synthase [Clostridium thermocellum ATCC 27405]
- gi|16080838|ref|NP_391666.1|_281:373 spsE [Bacillus subtilis subsp. subtilis str. 168]
- gi|730814|sp|P39625|SPSE_BACSU Spore coat polysaccharide biosynthesis protein spsE [Taxonomy]
- gi|629074|pir||S39722 spore coat polysaccharide synthesis protein spsE - Bacillus subtilis [Taxonomy]
- gi|413991|emb|CAA51623.1| ipa-67d [Bacillus subtilis]
- gi|2636322|emb|CAB15813.1| spsE [Bacillus subtilis subsp. subtilis str. 168]
- gi|34762796|ref|ZP_00143783.1|_22:109 N-acetylneuraminate synthase [Fusobacterium nucleatum subsp. vincentii ATCC 49256]
- gi|27887547|gb|EAA24630.1| N-acetylneuraminate synthase [Fusobacterium nucleatum subsp. vincentii ATCC 49256]
- gi|15718505|gb|AAL06005.1|_256:345 sialic acid synthase [Campylobacter jejuni]
- gi|15430484|gb|AAK96002.1|_256:345 putative sialic acid synthase [Campylobacter jejuni]
- gi|48833332|ref|ZP_00290352.1|_249:331 COG2089: Sialic acid synthase [Magnetococcus sp. MC-1]
- gi|12004283|gb|AAG43980.1|_256:345 sialic acid synthase [Campylobacter jejuni]
- gi|6969989|gb|AAF34144.1|_256:345 sialic acid synthase [Campylobacter jejuni]
- gi|40217907|gb|AAR82876.1| putative sialic acid synthase [Campylobacter jejuni]
- gi|31324511|gb|AAM76272.1|_256:342 NeuB3 [Campylobacter coli]
- gi|6940835|gb|AAF31772.1|_256:345 sialic acid synthase [Campylobacter jejuni]
- gi|15559181|gb|AAK58485.1|_256:342 NeuB3 [Campylobacter jejuni]
- gi|2125968|pir||I69836_254:341 neuB protein - Escherichia coli [Taxonomy]
- gi|454081|gb|AAC43302.1| neuB [Taxonomy]
- gi|1093227|prf||2103192B sialic acid synthase [Taxonomy]
- gi|15792640|ref|NP_282463.1|_256:342 N-acetylneuraminic acid synthetase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|11281336|pir||B81275 N-acetylneuraminic acid synthetase (EC 4.1.3.-) Cj1317 [imported] - Campylobacter jejuni (strain NCTC 11168) [Taxonomy]
- gi|6968751|emb|CAB73744.1| N-acetylneuraminic acid synthetase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|15824492|gb|AAL09369.1|_256:345 sialic acid synthase [Campylobacter jejuni]
- gi|15718490|gb|AAL05991.1|_256:345 sialic acid synthase [Campylobacter jejuni]
- gi|15792650|ref|NP_282473.1|_250:332 N-acetylneuraminic acid synthetase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|11281337|pir||D81276 N-acetylneuraminic acid synthetase (EC 4.1.3.-) Cj1327 [imported] - Campylobacter jejuni (strain NCTC 11168) [Taxonomy]
- gi|6968761|emb|CAB73754.1| N-acetylneuraminic acid synthetase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|11095584|gb|AAG29920.1|_145:227 NeuB [Campylobacter jejuni]
- gi|15193222|gb|AAK91726.1|_256:345 putative sialic acid synthase [Campylobacter jejuni]
- gi|15644807|ref|NP_206977.1|_249:336 spore coat polysaccharide biosynthesis protein E [Helicobacter pylori 26695]
- gi|7465379|pir||B64542 spore coat polysaccharide biosynthesis protein E - Helicobacter pylori (strain 26695) [Taxonomy]
- gi|2313267|gb|AAD07248.1| spore coat polysaccharide biosynthesis protein E [Helicobacter pylori 26695]
- gi|50590361|ref|ZP_00331750.1|_247:333 COG2089: Sialic acid synthase [Streptococcus suis 89/1591]
- gi|31324516|gb|AAM76277.1|_250:332 PtmC [Campylobacter coli]
- gi|18075741|emb|CAD11293.1|_34:121 sialic acid synthase [Helicobacter pylori]
- gi|18075745|emb|CAD11296.1| sialic acid synthase [Helicobacter pylori]
- gi|15792466|ref|NP_282289.1|_255:342 N-acetylneuraminic acid synthetase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|11281335|pir||H81318 N-acetylneuraminic acid synthetase (EC 4.1.3.-) Cj1141 [imported] - Campylobacter jejuni (strain NCTC 11168) [Taxonomy]
- gi|6968575|emb|CAB73396.1| N-acetylneuraminic acid synthetase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|14993925|gb|AAK73184.1| sialic acid synthase [Campylobacter jejuni]
- gi|15150370|gb|AAK85420.1| sialic acid synthase [Campylobacter jejuni]
- gi|18075737|emb|CAD11290.1|_36:123 sialic acid synthase [Helicobacter pylori]
- gi|15611236|ref|NP_222887.1|_249:336 sialic acid synthase [Helicobacter pylori J99]
- gi|7465362|pir||B71965 sialic acid synthase - Helicobacter pylori (strain J99) [Taxonomy]
- gi|4154681|gb|AAD05747.1| sialic acid synthase [Helicobacter pylori J99]
- gi|33864984|ref|NP_896543.1|_250:331 putative N-acetylneuraminic acid synthetase [Synechococcus sp. WH 8102]
- gi|33638668|emb|CAE06963.1| putative N-acetylneuraminic acid synthetase [Synechococcus sp. WH 8102]
- gi|11095588|gb|AAG29923.1|_255:342 SiaC [Campylobacter jejuni]
- gi|11527839|gb|AAG37021.1| putative sialic acid synthase [Campylobacter jejuni]
- gi|49235839|ref|ZP_00329904.1|_250:336 COG2089: Sialic acid synthase [Moorella thermoacetica ATCC 39073]
- gi|28896974|ref|NP_796579.1|_273:355 putative N-acetylneuraminic acid synthetase [Vibrio parahaemolyticus RIMD 2210633]
- gi|28805182|dbj|BAC58463.1| putative N-acetylneuraminic acid synthetase [Vibrio parahaemolyticus]
- gi|5616174|gb|AAD45660.1|_266:350 NeuB [Aeromonas punctata]
- gi|23127158|ref|ZP_00109033.1|_263:347 COG2089: Sialic acid synthase [Nostoc punctiforme]
- gi|34499486|ref|NP_903701.1|_274:356 N-acetylneuraminic acid synthase [Chromobacterium violaceum ATCC 12472]
- gi|34105336|gb|AAQ61691.1| N-acetylneuraminic acid synthase [Chromobacterium violaceum ATCC 12472]
- gi|33862379|ref|NP_893939.1|_266:352 N-acetylneuraminate synthase [Prochlorococcus marinus str. MIT 9313]
- gi|33640492|emb|CAE20281.1| N-acetylneuraminate synthase [Prochlorococcus marinus str. MIT 9313]
- gi|48859332|ref|ZP_00313268.1|_263:348 COG2089: Sialic acid synthase [Clostridium thermocellum ATCC 27405]
- gi|20560145|gb|AAM27877.1|_262:348 ORF_11; similar to NeuB family [Pseudomonas aeruginosa]
- gi|37678496|ref|NP_933105.1|_273:355 sialic acid synthase [Vibrio vulnificus YJ016]
- gi|37197236|dbj|BAC93076.1| sialic acid synthase [Vibrio vulnificus YJ016]
- gi|23473585|ref|ZP_00128881.1|_262:349 COG2089: Sialic acid synthase [Desulfovibrio desulfuricans G20]
- gi|23475934|ref|ZP_00131191.1| COG2089: Sialic acid synthase [Desulfovibrio desulfuricans G20]
- gi|34558392|ref|NP_908207.1|_251:336 SIALIC ACID SYNTHASE [Wolinella succinogenes DSM 1740]
- gi|34484111|emb|CAE11107.1| SIALIC ACID SYNTHASE [Wolinella succinogenes]
- gi|46142536|ref|ZP_00204328.1|_254:341 COG2089: Sialic acid synthase [Methanococcoides burtonii DSM 6242]
- gi|28211365|ref|NP_782309.1|_263:350 N-acetylneuraminate synthase [Clostridium tetani E88]
- gi|28203806|gb|AAO36246.1| N-acetylneuraminate synthase [Clostridium tetani E88]
- gi|15669254|ref|NP_248059.1|_247:334 spore coat polysaccharide biosynthesis protein E [Methanocaldococcus jannaschii DSM 2661]
- gi|3123092|sp|Q58465|YA65_METJA Hypothetical protein MJ1065 [Taxonomy]
- gi|2129290|pir||H64432 spore coat polysaccharide biosynthesis protein E homolog - Methanococcus jannaschii [Taxonomy]
- gi|1591717|gb|AAB99068.1| spore coat polysaccharide biosynthesis protein E [Methanocaldococcus jannaschii DSM 2661]
- gi|46914306|emb|CAG21085.1|_261:343 putative polysaccharide biosynthesis protein, NeuB [Photobacterium profundum]
- gi|20560097|gb|AAM27839.1|_262:347 ORF_13; similar to NeuB family [Pseudomonas aeruginosa]
- gi|20560120|gb|AAM27859.1| ORF_13; similar to NeuB family [Pseudomonas aeruginosa]
- gi|41725200|ref|ZP_00151958.1|_260:346 COG2089: Sialic acid synthase [Dechloromonas aromatica RCB]
- gi|15895456|ref|NP_348805.1|_263:348 Sialic acid synthase [Clostridium acetobutylicum ATCC 824]
- gi|25345168|pir||F97169 sialic acid synthase [imported] - Clostridium acetobutylicum [Taxonomy]
- gi|15025183|gb|AAK80145.1| Sialic acid synthase [Clostridium acetobutylicum ATCC 824]
- gi|48729590|ref|ZP_00263340.1|_263:347 COG2089: Sialic acid synthase [Pseudomonas fluorescens PfO-1]
- gi|27364257|ref|NP_759785.1|_251:332 Sialic acid synthase [Vibrio vulnificus CMCP6]
- gi|27360375|gb|AAO09312.1| Sialic acid synthase [Vibrio vulnificus CMCP6]
- gi|23014357|ref|ZP_00054178.1|_261:346 COG2089: Sialic acid synthase [Magnetospirillum magnetotacticum]
- gi|48824071|ref|ZP_00285499.1|_248:333 COG2089: Sialic acid synthase [Enterococcus faecium]
- gi|16127100|ref|NP_421664.1|_269:354 neuB protein, putative [Caulobacter crescentus CB15]
- gi|25345166|pir||D87604 neuB protein, probable [imported] - Caulobacter crescentus [Taxonomy]
- gi|13424484|gb|AAK24832.1| neuB protein, putative [Caulobacter crescentus CB15]
- gi|47565300|ref|ZP_00236342.1|_221:308 sialic acid synthase, putative [Bacillus cereus G9241]
- gi|47557654|gb|EAL15980.1| sialic acid synthase, putative [Bacillus cereus G9241]
- gi|48854590|ref|ZP_00308752.1|_261:346 COG2089: Sialic acid synthase [Cytophaga hutchinsonii]
- gi|41689345|ref|ZP_00145879.1|_35:118 COG2089: Sialic acid synthase [Psychrobacter sp. 273-4]
- gi|24214309|ref|NP_711790.1|_260:342 putative N-acetyl neuramic acid synthetase NeuB [Leptospira interrogans serovar Lai str. 56601]
- gi|45658022|ref|YP_002108.1| N-acetylneuraminate synthase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
- gi|24195230|gb|AAN48808.1| putative N-acetyl neuramic acid synthetase NeuB [Leptospira interrogans serovar lai str. 56601]
- gi|45601263|gb|AAS70745.1| N-acetylneuraminate synthase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
- gi|23016878|ref|ZP_00056630.1|_259:344 COG2089: Sialic acid synthase [Magnetospirillum magnetotacticum]
- gi|39997068|ref|NP_953019.1|_263:349 polysaccharide biosynthesis protein, putative [Geobacter sulfurreducens PCA]
- gi|39983958|gb|AAR35346.1| polysaccharide biosynthesis protein, putative [Geobacter sulfurreducens PCA]
- gi|32266407|ref|NP_860439.1|_261:347 sialic acid synthase [Helicobacter hepaticus ATCC 51449]
- gi|32262457|gb|AAP77505.1| sialic acid synthase [Helicobacter hepaticus ATCC 51449]
- gi|19705005|ref|NP_602500.1|_261:349 N-acetylneuraminate synthase [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
- gi|19712913|gb|AAL93799.1| N-acetylneuraminate synthase [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
- gi|15676004|ref|NP_273132.1|_263:347 polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis MC58]
- gi|2120917|pir||S60760 polysialic acid capsule biosynthesis protein SiaC NMB0068 [imported] - Neisseria meningitidis (strain MC58 serogroup B) [Taxonomy]
- gi|520735|gb|AAA20477.1| siaC [Neisseria meningitidis]
- gi|530040|emb|CAA54984.1| synC [Neisseria meningitidis serogroup B]
- gi|1399040|gb|AAB17455.1| capsule biosynthesis protein [Taxonomy]
- gi|7225288|gb|AAF40535.1| polysialic acid capsule biosynthesis protein SiaC [Neisseria meningitidis MC58]
- gi|1091228|prf||2020421C CMP-NeuNAc synthetase [Taxonomy]
- gi|46578765|ref|YP_009573.1|_267:350 NeuB family protein [Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough]
- gi|46448177|gb|AAS94832.1| NeuB family protein [Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough]
- gi|6688603|emb|CAB65212.1|_251:333 N-acetylneuraminic acid condensing enzyme [Legionella pneumophila]
- gi|45592938|ref|NP_996660.1|_262:350 Unknown (protein for MGC:77126); wu:fb73c01 [Danio rerio]
- gi|41351113|gb|AAH65584.1| Unknown (protein for MGC:77126) [Danio rerio]
- gi|48833985|ref|ZP_00291001.1|_416:504 COG2089: Sialic acid synthase [Magnetococcus sp. MC-1]
- gi|23473275|ref|ZP_00128571.1|_249:337 COG2089: Sialic acid synthase [Desulfovibrio desulfuricans G20]
- gi|2894127|emb|CAA04331.1|_256:326 sialic acid synthase [Campylobacter jejuni]
- gi|20559814|gb|AAM27589.1|_277:358 ORF_8; similar to NeuB family [Pseudomonas aeruginosa]
- gi|42526472|ref|NP_971570.1|_286:376 neuB family protein [Treponema denticola ATCC 35405]
- gi|41816665|gb|AAS11451.1| neuB family protein [Treponema denticola ATCC 35405]
- gi|42523180|ref|NP_968560.1|_272:353 putative N-acetylneuraminic acid synthetase [Bdellovibrio bacteriovorus HD100]
- gi|39575385|emb|CAE79553.1| putative N-acetylneuraminic acid synthetase [Bdellovibrio bacteriovorus HD100]
- gi|34499345|ref|NP_903560.1|_252:336 probable spore coat polysaccharide biosynthesis protein E [Chromobacterium violaceum ATCC 12472]
- gi|34105195|gb|AAQ61551.1| probable spore coat polysaccharide biosynthesis protein E [Chromobacterium violaceum ATCC 12472]
- gi|37813503|gb|AAR04516.1|_4:54 SynC [Neisseria meningitidis]
- gi|37813527|gb|AAR04532.1| SynC [Neisseria meningitidis]
- gi|37813494|gb|AAR04510.1|_4:54 SynC [Neisseria meningitidis]
- gi|37813497|gb|AAR04512.1| SynC [Neisseria meningitidis]
- gi|37813500|gb|AAR04514.1| SynC [Neisseria meningitidis]
- gi|37813506|gb|AAR04518.1| SynC [Neisseria meningitidis]
- gi|37813509|gb|AAR04520.1| SynC [Neisseria meningitidis]
- gi|37813512|gb|AAR04522.1| SynC [Neisseria meningitidis]
- gi|37813515|gb|AAR04524.1| SynC [Neisseria meningitidis]
- gi|37813518|gb|AAR04526.1| SynC [Neisseria meningitidis]
- gi|37813521|gb|AAR04528.1| SynC [Neisseria meningitidis]
- gi|37813524|gb|AAR04530.1| SynC [Neisseria meningitidis]
- gi|37813530|gb|AAR04534.1| SynC [Neisseria meningitidis]
- gi|37813533|gb|AAR04536.1| SynC [Neisseria meningitidis]
- gi|37813536|gb|AAR04538.1| SynC [Neisseria meningitidis]
- gi|37813539|gb|AAR04540.1| SynC [Neisseria meningitidis]
- gi|37813542|gb|AAR04542.1| SynC [Neisseria meningitidis]
- gi|37813545|gb|AAR04544.1| SynC [Neisseria meningitidis]
- gi|37813548|gb|AAR04546.1| SynC [Neisseria meningitidis]
- gi|37813551|gb|AAR04548.1| SynC [Neisseria meningitidis]
- gi|18150569|gb|AAL61654.1|_2:48 SiaC [Neisseria meningitidis]

              10         20          30        40         50         60
              |          |           |         |          |          |
   1 QGITKPVSEKLLGSSY.KTTTAIE..GEIRNFAYRGIFTTAPIQKGEAFSED.NIAVLRPGQK.P
   2 LVKGVRIVEQALGRFE.KIPDPVE..EKNKIVARKSVVALKPIKKGDIYSIE.NITVKRPG--.-
   3 LVKGVRIVEQALGRFE.KIPDPVE..EKNKIVARKSVVALKPIKKGDIYSIE.NITVKRPG--.-
   4 LVKGVRIVEQALGRFE.KIPDPVE..EKNKIVARKSVVALKPIKKGDIYSIE.NITVKRPG--.-
   5 LVKGVRIVEQALGRFE.KIPDPVE..EKNKIVARKSVVALKPIKKGDIYSIE.NITVKRPG--.-
   6 LCEGIRAVEKCLGSYA.KIVTKSE..QKNKIVARKSIVAKCNIKKGEIYTID.NITTKRPG--.-
   7 LVKGFALLNQALGRFE.KIPDPVE..EKNKIVARKSVVALKPIKKGDIYSIE.NITVKRPG--.-
   8 MIRALRNIELALGDGI.KKPSESE..KKNICVARKSIVAKRYIQKGEIFTEE.NLTVKRPG--.-
   9 --------EKLLGSSY.KTTTAIE..GEIRNFAYRGIFTTAPIQKGEAFSED.NIAVLRPGQK.P
  10 LCEGIRAVEKSMGKYK.KIVTNSE..RKNKIVARKSIIAKVKIKKGEIFTEE.NLTTKRPG--.-
  11 LIIQSEQMAIMRGNNEsKKAAKQE..QVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--.L
  12 LIIQSEQMAIMRGNNEsKKAAKQE..QVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--.L
  13 MVQGIRQVEQAMGDGI.KRPTPTE..LANRPIARKSIVARCAIRAGEPLTAE.NLTTKRPG--.-
  14 LIIQSEQMAIMRGNNEsKKAAKQE..QVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--.L
  15 LIMQSEQMAIMRGNNEsKKAAKQE..QVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--.L
  16 MVDAVRQAESALGDGK.LDLDEKA..LKNRVF-ARSLYASKDIKKGEMFSEE.NVKSVRPS--.-
  17 LIIQSEQMAIMRGNNEsKKAAKQE..QVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--.L
  18 MVDAVRQAESALGDGK.LDLDEKA..LKNRVF-ARSLYASKDIKKGEIFSEE.NVKSVRPS--.-
  19 LCIGVRCVEKSLGSNS.KVVTASE..RKNKIVARKSIIAKTEIKKGEVFSEK.NITTKRPG--.-
  20 MVDAVRQAESALGDGK.LDLDEKV..LKNRVF-ARSLYASKDIKKGEMFSEE.NVKSVRPS--.-
  21 LIIQSEQMAIMKGNNEsKKAAKQE..QVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--.L
  22 LIIQSEQMAIMKGNNEsKKAAKQE..QVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--.L
  23 LCTQIRQIQKAMGDGI.KKASKSE..QKNINIVRKSLVAKKDIKKGEIFSEG.NLTTKRPA--.-
  24 LCTQIRQIQKAMGDGI.KKASKSE..QKNINIVRKSLVAKKDIQKGEIFSEE.NLTTKRPA--.-
  25 LIIQSEQMAIIRGNNEsKKAAKQE..QVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--.L
  26 MVEAIKQSVLALGEEE.PRINPKT..LEKRRFFARSLFVIKDIQKGEALTEN.NIKALRPN--.-
  27 LVKGVRIVEQSLGKFE.KEPEEVE..VRNKIVARKSIVAKKAIAKGEVFTEE.NITVKRPG--.-
  28 LCTKIREIESALGDGI.KQASKSE..RKNIEIARKSLVAKKKIKKGEIFSEE.NLTTKRPA--.-
  29 MVGAIKQSVLALGEEE.PKINPKT..LEERRFFARSLFVIKDIQKGEALTEN.NIKALRPN--.-
  30 -INQTQEMVLLRGDNN.KNPLKEE..QVTIDFAFASVVSIKDIKKGEILSMD.NIWVKRPS--.K
  31 MVGAIKQSVLALGEEE.PKINPKT..LEERRFFARSLFVIKDIQKGEALTSD.NIKALRPN--.-
  32 MVGAIKQSVLALGEEE.PKINPKT..LEERRFFARSLFVIKDIQKGEALTSD.NIKALRPN--.-
  33 MVQGIRTIEQALGDGI.KRPTPSE..QSNLPVVRKSLVAACPIRAGEIFSEN.NLTAKRPG--.-
  34 -INQTQEMVLLRGDNN.KNPLKEE..QVTIDFAFASVVSIKDIKKGEILSMD.NIWVKRPS--.K
  35 MVVAIRQVEKSLGDGI.KRPAPGE..LAVMPAARRSLVAARDIAAGEIITDS.CLTAKRPG--.-
  36 MVKAIRQIEVALGSSV.KTPTESE..VKNKAVARKSLVAATDIKEGEELTEL.NLTIKRPG--.-
  37 LCKDAKTAWSALGSVN.YTRTEAE..KGNVKF-RRSLYVIRDIKAGDVLSND.NVRSIRPG--.-
  38 LVIESERAWQALGNIK.YGATEAE..KESLVF-RRSLYIAKDMKAGDIFTSE.NLRAVRPG--.-
  39 MVEGIRQVTVAIGDGC.KRPSADE..IGNRTIARRSLVAATAVKRGEIWTES.NLTCKRPG--.-
  40 LVDNVERAWQSLGSIH.YGPTDSE..IKSLCF-RRSIFISEDVSQGQILDES.NLKIVRPN--.-
  41 MVEDIRAAEKSIGKVS.YSISENE..AVSRSH-RRSIFVVKDIKKGEAFTEE.NIRIIRPA--.-
  42 LCRDSKTAWSALGKID.YGRKSSE..IGNVKF-RRSLYFVKDMRKGQLITQD.SIRSVRPG--.-
  43 MVKAIRQVELALGSAV.KSPTVSE..VKNKAVARKSLVASQAIQAGDAFSAD.NVTIKRPG--.-
  44 LVEGTRAVHQAMG-GH.KEILPDE..KPTIDFAYASVVAIRDIRAGDILSKD.NIWVKRPG--.-
  45 MVSSIHAASLALGEAN.YELSPKV..AKSKIF-KRSLFVCEKIQKGERFTPK.NLRSIRPG--.-
  46 MVRGIRLVEKARGSSV.KAPVESE..LEVRDIVRRSIVAKVNIPAGTVIAED.LLAFKRPG--.-
  47 LVREVRNLEAAMGHPR.KRVLKCE..EQGRKNSIRSLVVNRDIMKGEVIKKE.DLVALRPG--.-
  48 MVNNIRLVEKMLGSGE.KIPMPSE..RDVIVEARRSIVAKRNIKKGEYLSVD.NISFKRPG--.-
  49 LCKDAKTAWQSLGKVN.YERTEAE..KGNVKF-RRSLYVVKDIAEGEEFTSE.NVKSIRPG--.-
  50 LCRDSKTAWASLGIVD.YGRKSSE..AGNVKF-RRSLYAIRDIEAGEPLTAE.NIRSVRPG--.-
  51 LCQDARDAWSALGSLG.FERQQAE..EASKVF-RRSVYFVRDVSAGTVIGAE.HIRRIRPG--.-
  52 MVKSIREVEKALGKVT.YELTEKQ..KNSRQH-SRSLFVVKDIKKGETFTKE.NVKSIRPA--.-
  53 LVVETERAWQAMGQVH.YGVTEAE..QKSLVY-RRSLYVTTDMAAGEPFTAA.NLRAIRPG--.-
  54 MVTAIRNIEQALGNGW.KVPTKTE..QENRNIVRKSLVAGKPIMAGSIICAD.MLEIKRPG--.-
  55 LVRDCRAAWTARGRIS.YALAECE..QGSKGF-RRSLYVVEDLHPGETITED.KVRSIRPG--.-
  56 -VKHIRNTEIFLGDGV.KRAMPSE..LSTKEVSRKSLVVTENLNVGDILTEK.SLTIKRPG--.-
  57 LVDDTKNAWAALGRAH.YDVLGSE..ATSLLF-RRSLYVTADVKAGEPLTRA.NVRSVRPG--.-
  58 LIKGVAEVAKMRG-GK.KEAAKEE..KITIDFAFSTVVTIEDLRAGELITKD.NIWVKRPG--.-
  59 LVVETERAFLSLGKVN.YILSEKE..KKSLQF-KRSLYVVKDIKKGEAFTAL.NVRSIRPC--.-
  60 LCRDSKTTWAALGKVD.YGRKASE..QGNMKF-RRSLYFVKDLKAGDVITED.AVRSVRPG--.-
  61 MVSSIRNIEKSMGDGI.KKPSSSE..RKNIPIARKSIVATRNISKGEIFSES.NITTKRPG--.-
  62 -VAAIRRVEAMLGDQI.KRPTATE..LANMNGIRRGVVAARNLAAGTILDTT.MLVCKRPG--.-
  63 -VEEGRNIRIALGGGK.RIVTEAE..MEKRKKFRRSLVTRRALPQGHVLVEA.DLDAKRPG--.-
  64 MVEQVRDTALALGCKK.PKISADI..RKKRRQFARSIWVSADIKKGEKFTHK.NLSVVRPS--.-
  65 MVDASLELYYSLGDGI.KRIEKNE..EDTAMVQRRGIYITKSLKAGHILSRE.DLIALRPI-K.I
  66 ---GAHALKLARGGKK.DTIIAGE..KPTKDFAFASVVADKDIKKGELLSGD.NLWVKRPG--.-
  67 ---NMERVTGMVGPCN.ITSLPSE..EPARRNARRSLVAARAIPAGKVLEPA.DLTWKRPA--.-
  68 LVQSIRDAETVLGSGE.KKPSDNE..LPIRALVRRSITLRRDLVKGAQISKE.DLILLRPG--.-
  69 LVRSIRIVERALGTGL.KRMLPCE..VPCHDKLGKSVVAKTSIPKGTELTLD.MLAVKVAE--.P
  70 MVRRIREAEEVRGDGI.KQVQPQE..QELAAFARRGVQALQDIAPGEALLEGhNIAILRPGQQ.P
  71 -LKRIRRARTLQGSWV.KQPTDTEkaQGHVTSFRRSVYAAQDIAAGQLFTED.NLTVLRPA--.-
  72 MVDAVRQAESALGDGK.LDLDEKV..LKNRVF-ARSLYASKDIKKGEMFNEE.NVKSVRPS--.-
  73 MVAQIRMLEVALGSPY.KAPQPSE..WDTRQAARQQVVAARDIEAGMIITRD.DLTTARSG--.-
  74 --YSIELINEVIGSGE.KKLSPAE..TKNYGRTNRSIHYLNDLKKGDVITDK.DIAVLRTEKIlS
  75 MVDGIRAVEKAKGSFV.KGPTPAE..VLNRAVVRRSLVAKAEIQVNERFSEN.NLDAKRPG--.-
  76 ------RALAMLGDGEdDAVSETE..QASLRSLRRGVFATRPVAAGEALTAD.NVSFAFPP--.V
  77 ----------------.-------..--------------KDIKKGELLSGD.NLWVKRPG--.-
  78 ----------------.-------..--------------KDIKKGELLSGD.NLWVKRPG--.-
  79 ----------------.-------..------------------KGELLSGD.NLWVKRPG--.-


              70        80        90       100 
              |         |         |         | 
   1 QGLHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE
   2 NGISPMNWYDIL-GQEAQDDFEEDEVIRDSRF---------
   3 NGISPMNWYDIL-GQEAQDDFEEDEVIRDSRF---------
   4 NGISPMNWYDIL-GQEAQDDFEEDEVIRDSRF---------
   5 NGISPMNWYDIL-GQEAQDDFEEDEVIRDSRF---------
   6 NGISPMYWYDIL-GKKAEKNFDEDQLISHSGF---------
   7 NGISPMNWYDIL-GQEAQDDFEEDEVIRDSRF---------
   8 NGISPMQWFEVL-GRRAVRDFQEDELI--------------
   9 QGLHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE
  10 NGISPMNWYKIL-GKKAEKDFDIDELIEDSNF---------
  11 GGISAAEFENIL-GKKALRDIENDTQLSYEDF---------
  12 GGISASEFENIL-GKKALRDIENDTQLSYEDF---------
  13 DGLSPMYWDELV-GRPAQRDYAEDDPI--------------
  14 GGISASEFENIL-GKKALRDIENDTQLSYEDF---------
  15 GGISAVEFENIL-GKKALRDIENDTQLSYEDF---------
  16 FGLHPKFYQELL-GKKASKDIEFGDALKQGDF---------
  17 GGISAAEFENIL-GKKALRDIENDTQLSYEDF---------
  18 FGLHPKFYQELL-GKKASKDIEFGDALKESDF---------
  19 NGISPMEWYNLL-GKIAEQDFIPDELIIHSEF---------
  20 FGLHPKFYQELL-GKKASKDIKFGDALKQGDF---------
  21 GGISAAEFENIL-GKKALRDIENDTQLSYEDF---------
  22 GGISAAEFENIL-GKKALRDIENDTQLSYEDF---------
  23 NGISAMRYEEFL-GKIATKNYKEDELI--------------
  24 NGISAMRYEEFL-GKIATKNYKEDELI--------------
  25 GGISAAEFENIL-GKKALRDIENDAQLSYEDF---------
  26 LGLHPKFYKEIL-GQKASKFLKANTPLSADDI---------
  27 NGISPMEWYKVL-GQVSEQDFEEDQNICHSA----------
  28 SGISAMRYDEYL-GKKASKDYEEDELI--------------
  29 LGLHPKFYKEIL-GQKASKFLKANTPLSADDI---------
  30 GGISAKDFEAIL-GKRAKKDIKNNIQLTWDDF---------
  31 LGLHPKFYKEIL-GQKASKFLKANTPLNADDI---------
  32 LGLHPKFYKEIL-GQKASKFLKANTPLSADDI---------
  33 TGISPIHWDAWI-GRKASRDFAEDEM---------------
  34 GGISAKDFEAIL-GKRAKKDIKNNIQLTWDDF---------
  35 TGIPPNLWDVVV-GRQARRDIAAGSILSWDM----------
  36 SGLSPYRYWELI-GSKATKGYKAGELI--------------
  37 FGLAPKYLEQVL-GKTAIVDIKRGTPLSFE-----------
  38 LGLSPKYYDTIL-GKKIKQDAKIGTPISWN-----------
  39 DGVSPYRFWDFI-GKPATRDYRADEKL--------------
  40 SGLHPRFYEIVL-GRRAARSLSKGTPLSFDMV---------
  41 DGLEPKYFEQVL-NRRASQDIERGTPLKWTM----------
  42 FGVAPKYLESIV-GRTVSDDVRSGTAVSWDLI---------
  43 NGMSPYQYWEML-ERKASRDYQIGDLI--------------
  44 TGEILARDYERVLGRVAKRPLQKNAQLAWDDF---------
  45 HGLPPKHLNEIL-GKEAACDIERGEPLTWEM----------
  46 VGMPPKYLDRLI-GKVPISEIKKDSLINFEMF---------
  47 YGIKPYDKEKII-GLKIKKELKSGTVLTWDCF---------
  48 RGIETKYLSIIL-NRKIKNDKEEDDIIYWDDL---------
  49 FGLPPKNLINIL-GKRANMKIKFGTPLS-------------
  50 YGLSPKHYTEVL-GKTAAVKIPAHTPIHWEK----------
  51 MGLEPKYFDQLI-GRRVNQDVSRGTPVKWTHF---------
  52 FGLKTKYIEEVI-GKKARVDVKKGTPLDWNL----------
  53 LGLPPKHTDAVL-GRRARQPIKRGTPLDWS-----------
  54 NGISPTRWDEVV-GSIAKKDYQIGEL---------------
  55 YGLEPKFLPEIL-GRKARKAVPRGTAFDWSM----------
  56 NGIAPKFLYQYI-GKKVKRPISADSVLLEED----------
  57 NGLPPADLDKVL-AGKATRDLARGEPLDWSM----------
  58 TGEIKAEHFNSLLGKKVTRDIPRDEHLMWNDI---------
  59 NGLHTRYYDSVL-TKQANQDIKAGTPLSLDD----------
  60 FGLAPKFLEEVI-GKVVKEDVKENTAVVL------------
  61 DGLSPMNWDMVI-GKQARRDFQIDELI--------------
  62 GGIEPEDLDRLA-GFTLRRDLAEDEPLSWDD----------
  63 TGISPAEMTYAL-GRRLARDMQEDDVIRWEDL---------
  64 GGEHPRYLHKIL-GKSAKVALKAAQPLRLSD----------
  65 DGIQPYEIDLLL-GKKLTKNIESDSYLTWKD----------
  66 NGDFSVNEYETLFGKVAACNIRKGAQIKKTD----------
  67 HGISPRCYDEVV-GMKARADIAEDTVLKWGH----------
  68 TGIAPSEISNIV-GSRLSMNLSAGTNF--------------
  69 KGVAPEEIFQLV-GKKVTTDVEEDESITEDVV---------
  70 LGVHPRLLEQMQ-GRIAQRAIPAGQGVQL------------
  71 HGVCATRYEDFL-GRRAPRSMGAHEVLTAADL---------
  72 FGLHPIFYLELL-GKK-------------------------
  73 HGLPPTSLWELV-GSTSKRAFLAGET---------------
  74 PGEAPEMFDSFI-GAVLQRAVKSGEGLLMEDFL--------
  75 TGVSPMLFWEYL-SKSSSKAYAVDDL---------------
  76 EGQLTANEWSKYVRYTAKTPIAADAPVMAADL---------
  77 NGDFSVNEYESLFGKIAACDIRKGAQIKKTD----------
  78 NGDFSVNEYETLFGKVAACNIRKGAQIKKTD----------
  79 NGDFSVNEYESLFGKIAACDIRKGAQIKKTD----------