(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0222 spsE, Bacillus subtilis
    • gi|12056473|ref|NP_061819.2|_238:350 N-acetylneuraminic acid phosphate synthase; sialic acid synthase; N-acetylneuraminic acid phosphate synthase; sialic acid synthase; sialic acid phosphate synthase [Homo sapiens]
    • gi|20978759|sp|Q9NR45|SIAS_HUMAN Sialic acid synthase (N-acetylneuraminate synthase) (N-acetylneuraminic acid synthase) (N-acetylneuraminate-9-phosphate synthase) (N-acetylneuraminic acid phosphate synthase) [Taxonomy]
    • gi|12652539|gb|AAH00008.1| N-acetylneuraminic acid phosphate synthase [Homo sapiens]
    • gi|16716467|ref|NP_444409.1|_238:349 N-acetylneuraminic acid synthase (sialic acid synthase); N-acetylneuraminic acid 9-phosphate synthetase; sialic acid synthase; N-acetylneuraminic acid phosphate synthase [Mus musculus]
    • gi|13097042|gb|AAH03307.1| N-acetylneuraminic acid synthase (sialic acid synthase) [Mus musculus]
    • gi|26345280|dbj|BAC36290.1| unnamed protein product [Mus musculus]
    • gi|37046732|gb|AAH57977.1| N-acetylneuraminic acid synthase (sialic acid synthase) [Mus musculus]
    • gi|50761876|ref|XP_424866.1|_238:346 PREDICTED: similar to N-acetylneuraminic acid phosphate synthase; sialic acid synthase; N-acetylneuraminic acid phosphate synthase; sialic acid synthase; sialic acid phosphate synthase [Gallus gallus]
                  10         20        30        40             50     
                  |          |         |         |              |     
   1 HFTID....KNLPGA.DHSFALNPDELKEMVDGIRKTEAELKQGITKPV.....SEKLLGSSY..
   2 HFTID....KNLPGA.DHSFALNPDELKEMVDGIRKTEAELKQGITKPV.....SEKLLGSSY..
   3 HFTLD....RQLPGP.DHKASLEPAALGEMVQGIRQVEQAMGDGIKRP-.....---------..
   4 HFTLD....KNMEGP.DHALSADPEEFKEMVNNIRLVEKMLGSGEKIP-.....---------..
   5 HITLD....KTWKGS.DHSASLEPGELAELVRSVRLVERALGSPTKQL-.....---------..
   6 HITLD....KTWKGS.DHSASLEPGELAELVRSVRLVERALGSPTKQL-.....---------..
   7 HITLD....KTWKGS.DHSASLEPGELAELVRSVRLVERALGSPTKQL-.....---------..
   8 HFTLN....KNFEGP.DHKASVTPDELRLLCEGIRAVEKCLGSYAKIV-.....---------..
   9 HFTLD....TNMEGP.DHKASATPDILAALVKGVRIVEQALGRFEKIP-.....---------..
  10 HFTLD....TNMEGP.DHKASATPDILAALVKGVRIVEQALGRFEKIP-.....---------..
  11 HLTLD....KNMEGP.DHKSSLEPNEMKAMIRALRNIELALGDGIKKP-.....---------..
  12 HFTLD....TNMEGP.DHKASATPDILAALVKGVRIVEQALGRFEKIP-.....---------..
  13 HFTDS....MHRSGP.DIVCSMDTQALKELIIQSEQMAIMRGNNESKK-.....---------..
  14 HFTLD....TNMEGP.DHKASATPDILAALVKGVRIVEQALGRFEKIP-.....---------..
  15 HFTDS....MHRSGP.DIVCSMDTQALKELIIQSEQMAIMRGNNESKK-.....---------..
  16 HFTDS....MHRSGP.DIVCSMDTQALKELIIQSEQMAIMRGNNESKK-.....---------..
  17 HFTDS....MHRSGP.DIVCSMDTQALKELIIQSEQMAIMRGNNESKK-.....---------..
  18 HFTDS....MHRSGP.DIVCSMDTKALKELIIQSEQMAIMKGNNESKK-.....---------..
  19 HFTDS....MHRSGP.DIVCSMDTKALKELIIQSEQMAIMKGNNESKK-.....---------..
  20 HFTDS....MDRSGP.DIVCSMDTKALKELIMQSEQMAIMRGNNESKK-.....---------..
  21 HFTLD....KNMEGP.DHKASLEPQELGAMVKAIRQIEVALGSSVKTP-.....---------..
  22 HFTLD....KSMSGP.DHLASIEPDELKHLCIGVRCVEKSLGSNSKVV-.....---------..
  23 HFTDS....MHRSGP.DIVCSMDTKALKELIIQSEQMAIIRGNNESKK-.....---------..
  24 HFTLD....RNLPGP.DHMASLEPHELKAMVEGIRQVTVAIGDGCKRP-.....---------..
  25 HITLD....KTWKGS.DHSASLEPGELAELVRSVRLVERALGSPTKQL-.....---------..
  26 HLTLN....RTLPGP.DHKASLEPDQFAAMVQGIRTIEQALGDGIKRP-.....---------..
  27 HFTLD....REMEGN.DHKVSLLPGEFREMVDGIRQIEESLGNKNFRQ-.....---------..
  28 HFTLD....KNMSGP.DHKASLEPDELQELCTKIREIESALGDGIKQA-.....---------..
  29 HFTDT....MDRKGP.DIVCSMDESTLKDLINQTQEMVLLRGDNNKNP-.....---------..
  30 HFTLD....REMEGN.DHKVSLLPGEFREMVDGIRQIEESLGNKNFRQ-.....---------..
  31 HITLD....KTWKGS.DHLASLEPGELAELVRSVRLVERALGSPAKQL-.....---------..
  32 HFTLD....KNMEGP.DHKASLEPDELTAMVKAIRQVELALGSAVKSP-.....---------..
  33 HFTES....MDRKGP.DIVCSMDESTLKDLINQTQEMVLLRGDNNKNP-.....---------..
  34 HFTLD....KNLTGP.DHMASLEPTELEEMVRGIRLVEKARGSSVKAP-.....---------..
  35 HFTLD....NEMEGP.DHKASATPDILAALVKGVRIVEQSLGKFEKEP-.....---------..
  36 HFTLD....KELPGP.DHKASLDPQEFADFVKHIRNTEIFLGDGVKRA-.....---------..
  37 HFTLD....KNMSGP.DHKASLEPHELKTLCTQIRQIQKAMGDGIKKA-.....---------..
  38 HITLD....KTWKGS.DHSASLEPGELAELVRSVRLVERALGSPTKQL-.....---------..
  39 HFTLD....KNMSGP.DHKASLEPQELKMLCTQIRQIQKAMGDGIKKA-.....---------..
  40 HFTLD....KTMSGP.DHKASLEPQELADMVTAIRNIEQALGNGWKVP-.....---------..
  41 HFTVD....RSMEGN.DHKVSLLPEEFAEMVRQIRNIEEALGQGGERS-.....---------..
  42 HFILN....KSLQTP.DSAFSMDFNGFKSMVEAIKQSVLALGEEEPRI-.....---------..
  43 HITLD....KTWKGS.DHSASLEPGELAELVRSVRLVERALGSPTKQL-.....---------..
  44 HVTLD....KTWKGS.DHQASLEPKELAELVKAIRAVEKAMGSPIKQL-.....---------..
  45 HFTLD....RSLPGP.DHQASLDPQGLAAFVAAIRRVEAMLGDQIKRP-.....---------..
  46 HITLD....REMEGP.DHAASLEPEEFKALVTGIREVEAARGEKLAER-.....---------..
  47 HFILN....KSLQTP.DSAFSMDFNEFKSMVGAIKQSVLALGEEEPKI-.....---------..
  48 HVTLD....KTWKGN.DHQASLEPSELTELVSSIRLVEKAMGSTVKSL-.....---------..
  49 HFTLD....TNMEVP.DHKASATPDILAALVKGFALLNQALGRFEKIP-.....---------..
  50 HFTLN....RDGGGP.DDSFSLEPAELAALCRDSKTAWSALGKIDYGR-.....---------..
  51 HVTLD....KSWKGS.DHAASLEPEELAELVRSIRIVERALGTGLKRM-.....---------..
  52 HFILN....KSLQTP.DSAFSMDFNGFKSMVGAIKQSVLALGEEEPKI-.....---------..
  53 HFTLD....KNTDGP.DHWFSMDPEDMKSLVREVRNLEAAMGHPRKRV-.....---------..
  54 HFILN....KSLQTP.DSAFSMDFNGFKSMVGAIKQSVLALGEEEPKI-.....---------..
  55 HFMLD....KSIESE.DSKFSLDFDEFKAMVDAVRQAESALGDGKLDL-.....---------..
  56 HFTLN....RNGGGP.DDSFSLEPAELSALCRDSKTAWASLGIVDYGR-.....---------..
  57 HFTDS....KSRKGP.DIVCSMDPKELEELIKGVAEVAKMRGGKKEAA-.....---------..
  58 HFMLD....KSIESE.DSKFSLDFDEFKAMVDAVRQAESALGDGKLDL-.....---------..
  59 HVTMD....RNGGGA.DDSFSLEPHELAALCKDAKTAWSALGSVNYTR-.....---------..
  60 HFILS....RSLGGP.DGAFSLEPSEFKEMVSSIHAASLALGEANYEL-.....---------..
  61 HFCLS....REDGGV.DSAFSLEPSEFRDLVDNVERAWQSLGSIHYGP-.....---------..
  62 HFMLD....KSIESE.DSKFSLDFDEFKAMVDAVRQAESALGDGKLDL-.....---------..
  63 HFCLS....REIKSP.DSSFSMEPDEFKKMVEDIRAAEKSIGKVSYSI-.....---------..
  64 HVTLD....KTWKGS.DHAASLEPSELAELVRSIRLVERALGNGVKRM-.....---------..
  65 HITLD....KTWKGS.ENLASLEPGELAELVRSVRLVEWALGSPTKQL-.....---------..
  66 HFTLD....QDMEGW.DHAISATPTDLRTIVEEGRNIRIALGGGKRIV-.....---------..
  67 HFILD....RNDKGP.DSSFSIEPNELTSLIEQTNDAWLSLGQAGYER-.....---------..
  68 HFTLR....RVDGGV.DSAFSMEPEEMQQLVIESERAWQALGNIKYGA-.....---------..
  69 HFTLD....RNAGGP.DDSFSLEPTDLTALCRDSKTTWAALGKVDYGR-.....---------..
  70 HFTLD....KNLPGP.DHKASLEPNELKTMVSSIRNIEKSMGDGIKKP-.....---------..
  71 HFTLS....RADKGP.DSEFSLEPDELRRLCQDARDAWSALGSLGFER-.....---------..
  72 HFTLD....RSMPGP.DHKASLEPGELAQMVAQIRMLEVALGSPYKAP-.....---------..
  73 HITID....RGMEGN.DHKVSLLPDEFAQMMQGIRRVEESMGQGGERS-.....---------..
  74 HLTLD....RNAPGP.DHAASLEPGDFGRMVSAIRNVEAALGDGVKTP-.....---------..
  75 HFTDR....MDRPGP.DIVCSMNPDTFKELKQGAHALKLARGGKKDTI-.....---------..
  76 HFTCD....KLWPGP.DVPISVDPGELKRLVEGTRAVHQAMGGHKEIL-.....---------..
  77 HFTLD....RSAGGV.DASFSLEPAELASLVVETERAWQAMGQVHYGV-.....---------..
  78 HFTMD....KSLPGP.DHLASMDPEEMKNLVQSIRDAETVLGSGEKKP-.....---------..
  79 -----....-NLEGP.DHKASVLPEELKLLCEGIRAVEKSMGKYKKIV-.....---------..
  80 HVTLD....RSGGGA.DDSFSLEPIELAQLCKDAKTAWQSLGKVNYER-.....---------..
  81 HLTVD....RNLPGP.DHRASLEPGEFKEMVVAIRQVEKSLGDGIKRP-.....---------..
  82 HFTLD....RNLPGP.DHRASLEPQELKNMVDGIRAVEKAKGSFVKGP-.....---------..
  83 HFTLA....RADGGP.DAAFSLEPAEFKALVDDTKNAWAALGRAHYDV-.....---------..
  84 HFTLD....KAWKGT.DHQASLNPAEFGRMVRCIRAIENDEIDPHHRQ-.....---------..
  85 HFTLR....RADGGL.DSHFSLEPEELVQLVRDCRAAWTARGRISYAL-.....---------..
  86 HFTDD....NDREGP.DHKFAMNPKTWREMVDASLELYYSLGDGIKRI-.....---------..
  87 HFTLS....RADGGV.DSSFSLEPEELKNLVVETERAFLSLGKVNYIL-.....---------..
  88 HFSHD....KTLPGN.DHYHAMDKDDLKVFRTNMERVTGMVGPCNITS-.....---------..
  89 HFILD....SSLGGV.DSAFSMNKDEFKAMVEQVRDTALALGCKKPKI-.....---------..
  90 HYTLH....NALPGP.DHSFAITADELTQMVRRIREAEEVRGDGIKQV-.....---------..
  91 HFTLK....RSDGGP.DSAFSMEPEEFSAMVKSIREVEKALGKVTYEL-.....---------..
  92 HFTLD....KSQKGS.DHRCSLEPQELKALTTAITNFKLSSVPMPPQEI.....VKKLNGDEEl1
  93 HVTID....RHMKGT.DQLGSLGPDGVNRMIRDIRIAECWLGTEDLYI-.....---------..
  94 HFMLD....KSIESE.DSKFILDFDEFKAMVDAVRQAESALGDGKLDL-.....---------..
  95 HICLS....RKEEGL.DDPVALEPDMFKKMCSALNSFSKKTYDEIIEGLtk9elINEVIGSGE..
  96 HFTDT....REGKSFrDHLVSITRDELRDLLKRIRRARTLQGSWVKQP-.....---------..
  97 HICLS....RTDAGL.DDSIALDPADFRTMTAALNSCARRSPSQIISFLhe9hvVRAVIGSGE..
  98 HFTTDpalmERIPDA.DHDISITPAQLRELRLAAERTALALGGAERVL-.....---------..
  99 -----....------.---YSANPEQVRRWLAAAARALAMLGDGEDDA-.....---------..
 100 HITLD....RTMWGS.DHAASLEPAGLQHLVRDIRVIEQALGDGVKRV-.....---------..
 101 HFTLD....KNLDGP.DHVISANPEELKNVCESAFTSWKMKGNGEKKP-.....---------..
 102 HITLD....RAMWGS.DQAASVEPQGLTRLVRDIRTIEASLGDGVKKV-.....---------..
 103 HITLD....RAMWGS.DQAASVEPQGLTRLVRDIRTIEASLGDGVKKV-.....---------..


              60        70        80         90        100       110   
              |         |         |          |          |         |   
   1 ...KTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSED.NIAVLRPGQKP.QGLHPRFFELLTSGVR
   2 ...KTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSED.NIAVLRPGQKP.QGLHPRFFELLTSGVR
   3 ...---TPTELANRPIARKSIVARCAIRAGEPLTAE.NLTTKRPG---.DGLSPMYWDELV-GRP
   4 ...---MPSERDVIVEARRSIVAKRNIKKGEYLSVD.NISFKRPG---.RGIETKYLSIIL-NRK
   5 ...---LPCEMACNEKLGKSVVAKVKIPEGTILTMD.MLTVKVGE--P.KGYPPEDIFNLV-GKK
   6 ...---LPCEMACNEKLGKSVVAKVKIPEGTILTMD.MLTVKVGE--P.KGYPPEDIFNLV-GKK
   7 ...---LPCEMACNEKLGKSVVAKVKIPEGTILTMD.MLTVKVGE--P.KGYPPEDIFNLV-GKK
   8 ...---TKSEQKNKIVARKSIVAKCNIKKGEIYTID.NITTKRPG---.NGISPMYWYDIL-GKK
   9 ...---DPVEEKNKIVARKSVVALKPIKKGDIYSIE.NITVKRPG---.NGISPMNWYDIL-GQE
  10 ...---DPVEEKNKIVARKSVVALKPIKKGDIYSIE.NITVKRPG---.NGISPMNWYDIL-GQE
  11 ...---SESEKKNICVARKSIVAKRYIQKGEIFTEE.NLTVKRPG---.NGISPMQWFEVL-GRR
  12 ...---DPVEEKNKIVARKSVVALKPIKKGDIYSIE.NITVKRPG---.NGISPMNWYDIL-GQE
  13 ...--AAKQEQVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--L.GGISAAEFENIL-GKK
  14 ...---DPVEEKNKIVARKSVVALKPIKKGDIYSIE.NITVKRPG---.NGISPMNWYDIL-GQE
  15 ...--AAKQEQVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--L.GGISAAEFENIL-GKK
  16 ...--AAKQEQVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--L.GGISASEFENIL-GKK
  17 ...--AAKQEQVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--L.GGISASEFENIL-GKK
  18 ...--AAKQEQVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--L.GGISAAEFENIL-GKK
  19 ...--AAKQEQVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--L.GGISAAEFENIL-GKK
  20 ...--AAKQEQVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--L.GGISAVEFENIL-GKK
  21 ...---TESEVKNKAVARKSLVAATDIKEGEELTEL.NLTIKRPG---.SGLSPYRYWELI-GSK
  22 ...---TASERKNKIVARKSIIAKTEIKKGEVFSEK.NITTKRPG---.NGISPMEWYNLL-GKI
  23 ...--AAKQEQVTIDFAFASVVSIKDIKKGEVLSMD.NIWVKRPG--L.GGISAAEFENIL-GKK
  24 ...---SADEIGNRTIARRSLVAATAVKRGEIWTES.NLTCKRPG---.DGVSPYRFWDFI-GKP
  25 ...---LPCEMACNEKLGKSVVAKVKIPEGTILTMD.MLTVKVGE--P.KAYPPEDIFNLV-GKK
  26 ...---TPSEQSNLPVVRKSLVAACPIRAGEIFSEN.NLTAKRPG---.TGISPIHWDAWI-GRK
  27 ...--ITQGELMNRETLGKSLLINRDLKLGEIITSD.MVDIRSPG---.KGLPPYFKEKLI-GKS
  28 ...---SKSERKNIEIARKSLVAKKKIKKGEIFSEE.NLTTKRPA---.SGISAMRYDEYL-GKK
  29 ...---LKEEQVTIDFAFASVVSIKDIKKGEILSMD.NIWVKRPS--K.GGISAKDFEAIL-GKR
  30 ...--ITQGELMNRETLGKSLLINRDLKLGEIITSD.MVDIRSPG---.KGLPPYFKEKLI-GKS
  31 ...---LPCEMACNEKLGKSVVAKVKIPAGTILTLD.MLTVKVGE--P.KGYPPEDIFNLV-GKK
  32 ...---TVSEVKNKAVARKSLVASQAIQAGDAFSAD.NVTIKRPG---.NGMSPYQYWEML-ERK
  33 ...---LKEEQVTIDFAFASVVSIKDIKKGEILSMD.NIWVKRPS--K.GGISAKDFEAIL-GKR
  34 ...---VESELEVRDIVRRSIVAKVNIPAGTVIAED.LLAFKRPG---.VGMPPKYLDRLI-GKV
  35 ...---EEVEVRNKIVARKSIVAKKAIAKGEVFTEE.NITVKRPG---.NGISPMEWYKVL-GQV
  36 ...---MPSELSTKEVSRKSLVVTENLNVGDILTEK.SLTIKRPG---.NGIAPKFLYQYI-GKK
  37 ...---SKSEQKNINIVRKSLVAKKDIQKGEIFSEE.NLTTKRPA---.NGISAMRYEEFL-GKI
  38 ...---LPCEMACNEKLGKSVVAKVKIPAGTTLTLD.MLTVKVGE--P.KGYPPEDIFNLA-GKK
  39 ...---SKSEQKNINIVRKSLVAKKDIKKGEIFSEG.NLTTKRPA---.NGISAMRYEEFL-GKI
  40 ...---TKTEQENRNIVRKSLVAGKPIMAGSIICAD.MLEIKRPG---.NGISPTRWDEVV-GSI
  41 ...--LTQGEMINRENLAKSLVINCDLSQGQLIRRS.MITVKSPG---.QGLQPNRIDELA-GKV
  42 ...---NPKTLEKRRFFARSLFVIKDIQKGEALTEN.NIKALRPN---.LGLHPKFYKEIL-GQK
  43 ...---LPCEMACNEKLGKSVVAKVKIPAGTTLTLD.TLTVKVGE--P.KGYPPEDIFNLA-GKK
  44 ...---LPCEMACNEKLGKSVVAKVTIPEGTILTLD.MLTVKVGE--P.KGFAPEAIFDLV-GQK
  45 ...---TATELANMNGIRRGVVAARNLAAGTILDTT.MLVCKRPG---.GGIEPEDLDRLA-GFT
  46 ...-ALSQGELINRENLAKSLVAARDIEAGTVISDD.DIAVKSPG---.QGLSPLKMPALI-GKI
  47 ...---NPKTLEERRFFARSLFVIKDIQKGEALTSD.NIKALRPN---.LGLHPKFYKEIL-GQK
  48 ...---LPCELACHNKLGKSVVAKVKIPAGTVLTLN.MLTVKVAE--P.RGFPPEEIYDLE-GKT
  49 ...---DPVEEKNKIVARKSVVALKPIKKGDIYSIE.NITVKRPG---.NGISPMNWYDIL-GQE
  50 ...----KSSEIGNVKFRRSLYFVKDMRKGQLITQD.SIRSVRPG---.FGVAPKYLESIV-GRT
  51 ...---LPCEVPCHDKLGKSVVAKTSIPKGTELTLD.MLAVKVAE--P.KGVAPEEIFQLV-GKK
  52 ...---NPKTLEERRFFARSLFVIKDIQKGEALTSD.NIKALRPN---.LGLHPKFYKEIL-GQK
  53 ...---LKCEEQGRKNSIRSLVVNRDIMKGEVIKKE.DLVALRPG---.YGIKPYDKEKII-GLK
  54 ...---NPKTLEERRFFARSLFVIKDIQKGEALTEN.NIKALRPN---.LGLHPKFYKEIL-GQK
  55 ...----DEKALKNRVFARSLYASKDIKKGEIFSEE.NVKSVRPS---.FGLHPKFYQELL-GKK
  56 ...----KSSEAGNVKFRRSLYAIRDIEAGEPLTAE.NIRSVRPG---.YGLSPKHYTEVL-GKT
  57 ...----KEEKITIDFAFSTVVTIEDLRAGELITKD.NIWVKRPG---.TGEIKAEHFNSLLGKK
  58 ...----DEKVLKNRVFARSLYASKDIKKGEMFSEE.NVKSVRPS---.FGLHPKFYQELL-GKK
  59 ...----TEAEKGNVKFRRSLYVIRDIKAGDVLSND.NVRSIRPG---.FGLAPKYLEQVL-GKT
  60 ...----SPKVAKSKIFKRSLFVCEKIQKGERFTPK.NLRSIRPG---.HGLPPKHLNEIL-GKE
  61 ...---TDSEIKSL-CFRRSIFISEDVSQGQILDES.NLKIVRPN---.SGLHPRFYEIVL-GRR
  62 ...----DEKALKNRVFARSLYASKDIKKGEMFSEE.NVKSVRPS---.FGLHPKFYQELL-GKK
  63 ...----SENEAVSRSHRRSIFVVKDIKKGEAFTEE.NIRIIRPA---.DGLEPKYFEQVL-NRR
  64 ...---LPCEKPCHDKLGKSVVAKVRIPKGTVLTAD.MLAVKVAE--P.MGVKAEEIFELV-GKT
  65 ...---LPCEMACNEKLGKSVVAQVKIPAGTILTLD.ILTVKVGE--P.KGYPPEDIFNLV-GKM
  66 ...---TEAEMEKRKKFRRSLVTRRALPQGHVLVEA.DLDAKRPG---.TGISPAEMTYAL-GRR
  67 ...----KPAEEANIKFRRSVYFVKDLPAGSLVTAD.SIRRIRPG---.LGLAPKHEQEII-GKR
  68 ...----TEAEKESLVFRRSLYIAKDMKAGDIFTSE.NLRAVRPG---.LGLSPKYYDTIL-GKK
  69 ...----KASEQGNMKFRRSLYFVKDLKAGDVITED.AVRSVRPG---.FGLAPKFLEEVI-GKV
  70 ...---SSSERKNIPIARKSIVATRNISKGEIFSES.NITTKRPG---.DGLSPMNWDMVI-GKQ
  71 ...----QQAEEASKVFRRSVYFVRDVSAGTVIGAE.HIRRIRPG---.MGLEPKYFDQLI-GRR
  72 ...---QPSEWDTRQAARQQVVAARDIEAGMIITRD.DLTTARSG---.HGLPPTSLWELV-GST
  73 ...--ISQGEMMNREVLAKSLVAACDVPAGTEITEA.MVRIQSPG---.QGLQPNRLNDLI-GRR
  74 ...---KESEVRNVPVARKSIVAARALRAGEIIGPA.DITAKRPG---.AGRPPIDYWSLI-GTA
  75 ...---IAGEKPTKDFAFASVVADKDIKKGELLSGD.NLWVKRPG---.NGDFSVNEYETLFGKV
  76 ...----PDEKPTIDFAYASVVAIRDIRAGDILSKD.NIWVKRPG---.TGEILARDYERVLGRV
  77 ...---TEAEQKSL-VYRRSLYVTTDMAAGEPFTAA.NLRAIRPG---.LGLPPKHTDAVL-GRR
  78 ...---SDNELPIRALVRRSITLRRDLVKGAQISKE.DLILLRPG---.TGIAPSEISNIV-GSR
  79 ...---TNSERKNKIVARKSIIAKVKIKKGEIFTEE.NLTTKRPG---.NGISPMNWYKIL-GKK
  80 ...----TEAEKGNVKFRRSLYVVKDIAEGEEFTSE.NVKSIRPG---.FGLPPKNLINIL-GKR
  81 ...---APGELAVMPAARRSLVAARDIAAGEIITDS.CLTAKRPG---.TGIPPNLWDVVV-GRQ
  82 ...---TPAEVLNRAVVRRSLVAKAEIQVNERFSEN.NLDAKRPG---.TGVSPMLFWEYL-SKS
  83 ...----LGSEATSLLFRRSLYVTADVKAGEPLTRA.NVRSVRPG---.NGLPPADLDKVL-AGK
  84 ...--LLECERPCYNKLGKSLVYASDLNCGTVLTES.NVQVKVSE--P.KGLSPRLYDSVV-GRT
  85 ...---AECEQGSK-GFRRSLYVVEDLHPGETITED.KVRSIRPG---.YGLEPKFLPEIL-GRK
  86 ...---EKNEEDTAMVQRRGIYITKSLKAGHILSRE.DLIALRPI-KI.DGIQPYEIDLLL-GKK
  87 ...----SEKEKKSLQFKRSLYVVKDIKKGEAFTAL.NVRSIRPC---.NGLHTRYYDSVL-TKQ
  88 ...---LPSEEPARRNARRSLVAARAIPAGKVLEPA.DLTWKRPA---.HGISPRCYDEVV-GMK
  89 ...---SADIRKKRRQFARSIWVSADIKKGEKFTHK.NLSVVRPS---.GGEHPRYLHKIL-GKS
  90 ...---QPQEQELAAFARRGVQALQDIAPGEALLEGhNIAILRPGQQP.LGVHPRLLEQMQ-GRI
  91 ...----TEKQKNSRQHSRSLFVVKDIKKGETFTKE.NVKSIRPA---.FGLKTKYIEEVI-GKK
  92 0esKTILPCELPCRNKLGKSIVAARNLNKGYRLQLA.DMAIKVSE--P.SGLTAEDFLDLV-GKE
  93 ...---EKGVEKSKIKLERSIATRKYIPAGSIIQES.DIHLLSPG---.DGYKWIDKKNVI-GHF
  94 ...----DEKVLKNRVFARSLYASKDIKKGEMFNEE.NVKSVRPS---.FGLHPIFYLELL-GKK
  95 ...KKLSPAETKNYGRTNRSIHYLNDLKKGDVITDK.DIAVLRTEKILsPGEAPEMFDSFI-GAV
  96 ...-TDTEKAQGHVTSFRRSVYAAQDIAAGQLFTED.NLTVLRPA---.HGVCATRYEDFL-GRR
  97 ...KVLAPSERAHYQKSNRSLHYLHAYPRGTVLQKE.NLVIVRSEANLsAGEAPEHANLFV-GAV
  98 ...---APQESAGRTASRRGLYARTRLAAGHILRAE.DVTALRPV---.AALPASALDAVL-GRP
  99 ...--VSETEQASLRSLRRGVFATRPVAAGEALTAD.NVSFAFPP--V.EGQLTANEWSKYVRYT
 100 ...---FPGEEEPRKRLRR-----------------.-----------.----------------
 101 ...---WPEEINGRFFGRRSLYAD---------S--.-----------.----------------
 102 ...---YESELGPMKKLRR-----------------.-----------.----------------
 103 ...---YDSELGPMKKLRR-----------------.-----------.----------------


          120       130        
           |         |        
   1 AVRDIPADTGIVWDDILLKDSPFHE
   2 AVRDIPADTGIVWDDILLKDSPFH-
   3 AQRDYAEDDPI--------------
   4 IKNDKEEDDIIYWDDL---------
   5 VLVTVEEDDTIMEELV---------
   6 VLVTVEEDDTIMEELV---------
   7 VLVTVEEDDTIMEELV---------
   8 AEKNFDEDQLISHSG----------
   9 AQDDFEEDEVIRDSR----------
  10 AQDDFEEDEVIRDSR----------
  11 AVRDFQEDEL---------------
  12 AQDDFEEDEVIRDSR----------
  13 ALRDIENDTQLSYEDF---------
  14 AQDDFEEDEVIRDSR----------
  15 ALRDIENDTQLSYEDF---------
  16 ALRDIENDTQLSYEDF---------
  17 ALRDIENDTQLSYEDF---------
  18 ALRDIENDTQLSYEDF---------
  19 ALRDIENDTQLSYEDF---------
  20 ALRDIENDTQLSYEDF---------
  21 ATKGYKAGELI--------------
  22 AEQDFIPDELIIHSE----------
  23 ALRDIENDAQLSYEDF---------
  24 ATRDYRADEKL--------------
  25 VLVTVEEDDTIMEELV---------
  26 ASRDFAEDEM---------------
  27 AKRDFKKGDFFYKSDI---------
  28 ASKDYEEDELI--------------
  29 AKKDIKNNIQLTWDDF---------
  30 AKRDFKKGDFFYKSDI---------
  31 VLVTIEEDDTVMEES----------
  32 ASRDYQIGDLI--------------
  33 AKKDIKNNIQLTWDDF---------
  34 PISEIKKDSLINFEMF---------
  35 SEQDFEEDQNICHS-----------
  36 VKRPISADSVLLEED----------
  37 ATKNYKEDELI--------------
  38 VLVTIEEDDTVMEES----------
  39 ATKNYKEDELI--------------
  40 AKKDYQIGE----------------
  41 AQRDFKAGDFFFETDI---------
  42 ASKFLKANTPLSADDI---------
  43 VLVTIEEDDTVMEES----------
  44 VKKTIEEDETIT-------------
  45 LRRDLAEDEPLSWDD----------
  46 LKRKMAADDYFFQSDL---------
  47 ASKFLKANTPLNADDI---------
  48 VKREIPEDESVTEEAI---------
  49 AQDDFEEDEVIRDSR----------
  50 VSDDVRSGTAVSWDLI---------
  51 VTTDVEEDESITEDV----------
  52 ASKFLKANTPLSADDI---------
  53 IKKELKSGTVLTWDC----------
  54 ASKFLKANTPLSADDI---------
  55 ASKDIEFGDALKESD----------
  56 AAVKIPAHTPIHWE-----------
  57 VTRDIPRDEHLMWNDI---------
  58 ASKDIKFGDALKQGD----------
  59 AIVDIKRGTPLSFE-----------
  60 AACDIERGEPLTWEM----------
  61 AARSLSKGTPLSFDMV---------
  62 ASKDIEFGDALKQGD----------
  63 ASQDIERGTPLKWTM----------
  64 VMENVEEDESV--------------
  65 VLVTIEEDDTVLEES----------
  66 LARDMQEDDVIRWEDL---------
  67 LKTSVTRGTPTSWDLF---------
  68 IKQDAKIGTPISWN-----------
  69 VKEDVKENTAVV-------------
  70 ARRDFQIDEL---------------
  71 VNQDVSRGTPVKWTH----------
  72 SKRAFLAGE----------------
  73 LPVAKAQGEVFFPSDL---------
  74 APRALEPDD----------------
  75 AACNIRKGAQIKKTD----------
  76 AKRPLQKNAQLAWDDF---------
  77 ARQPIKRGTPLDWS-----------
  78 LSMNLSAGTNF--------------
  79 AEKDFDIDELIEDS-----------
  80 ANMKIKFGTPLSE------------
  81 ARRDIAAGSILSWDM----------
  82 SSKAYAVDD----------------
  83 ATRDLARGEPLDWSM----------
  84 VKCAVFKDDPI--------------
  85 ARKAVPRGTAFDWSM----------
  86 LTKNIESDSYLTWKD----------
  87 ANQDIKAGTPLSLDD----------
  88 ARADIAEDTVLKWG-----------
  89 AKVALKAAQPLRLSD----------
  90 AQRAIPAGQGVQLG-----------
  91 ARVDVKKGTPLDWN-----------
  92 LADNIGEDEPILGNS----------
  93 AKQDISANEIIYPDF----------
  94 -------------------------
  95 LQRAVKSGEGLLMEDFL--------
  96 APRSMGAHEVLTAAD----------
  97 LQRSVHAGEGARFGDIIQKGT----
  98 CPCDLAPLAPIPASML---------
  99 AKTPIAADAPVMAADL---------
 100 -------------------------
 101 -------------------------
 102 -------------------------
 103 -------------------------