(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0211 HR1958, human
    • gi|16975123|pdb|1JHJ|A_25:165 Chain A, Crystal Structure Of The Apc10DOC1 SUBUNIT OF THE HUMAN Anaphase-Promoting Complex [Taxonomy]
    • gi|37362650|ref|NP_011274.2|_89:227 Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; Doc1p [Saccharomyces cerevisiae]
                      10           20        30        40        50    
                      |            |         |         |         |    
   1 .....MRKIDLC..LS.SEG.S.E.VILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFH
   2 .....-------..-R.EIG.S.QaVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFR
   3 .....-------..-R.EIG.S.QaVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFR
   4 .....-------..-R.EIG.S.QaVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFR
   5 .....-------..-R.EIG.S.QaVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFR
   6 ny...KLIIDDD..LR.EMGkN.A.AWSVSSCKPGNGVTTLRDDNLETYWQSDGLQPHLINIQFQ
   7 ny...KLIIDDD..LR.EMGkN.A.AWSVSSCKPGNGVTTLRDDNLETYWQSDGLQPHLINIQFQ
   8 .....-------..-R.EIG.S.QaVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFR
   9 .....-------..-R.EIG.S.QaVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFR
  10 edp..LAEERLG..FVrEVG.A.QaVWSLSSCKPGFGVERLRDNIMDTYWQSDGQLPHLVNIQFH
  11 idp..IQKELAG..RVrEVG.NhA.IWSLSSCKPGFGVDQLRDDITETYWQSDGQLPHLVNIQFK
  12 .....MRKVDLC..SV.TEG.T.E.VILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFH
  13 pel..MVDDDMR..EM.AK-.T.A.AWSVSSCKPGNGVASLRDDNLDTYWQSDGAQPHLVNIQFQ
  14 .....-------..--.EVG.G.QaVWSLSSCKPGFGVDQLRDNSMETYWQSDGQLPHLVNIQFH
  15 .....MRKVDLC..SV.TEG.T.E.VILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFH
  16 .....MRKIDLC..LS.SEG.S.E.VILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFH
  17 .....-------..--.--H.L.A.LWKPSSFKLGNPVDFALDDNYDTFWQSDGGQPHQLDIMFS
  18 .....-------..--.--H.L.A.LWKPSSFKLGNPVDFALDDNYDTFWQSDGGQPHQLDIMFS
  19 .....-------..--.--H.L.A.LWKPSSFKLGNPVDFALDDNYDTFWQSDGGQPHQLDIMFS
  20 .....-------..--.--H.L.A.LWKPSSFKLGNPVDFALDDNYDTFWQSDGGQPHQLDIMFS
  21 pkn..VEPRDSP..LL.DIS.N.QaIWTVSSCKNGYGIDELMSDNVEKYWQSDGPQPHTIHLEFQ
  22 .....-------..--.---.L.A.YWKPSSFKAGYPIENALDDNPATFWQSDGSQPHTIDVFFS
  23 .....-------..--.---.-.-.HFSVSSHKPGNGVAELLSDDLDKYWQSDGQQPHLLTMHFL
  24 lk7seTQKSTEG..FV.DIG.NlA.QWTCSSEKSGFPIRLVRDDNIDTYWQSDGSQPHTIHIKFV
  25 .....-------..--.---.L.A.RFTVSSHKPGNGVEELKSDDLKQFWQSDGPQPHKLTMYFT
  26 thr..LPKIRLSkkYV.ELG.ClG.VWKLSSFKNKFNVKNLRDIDPNTYWQTDSLAPHTITIQFI
  27 .....MA--NSS..LG.SLG.A.K.VVVISSSDENHPPENIIDGTTQTFWMSTGLFPQEFIIRFT
  28 .....MRKIDLC..LS.SEG.S.E.VILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFH
  29 .....-------..--.---.M.E.-IRLSSFKREHSLRELLSKDMSEYWATDDVLPHSIQISFD
  30 knn..LPKIKISkkYV.EVG.ClG.IWKLSSSKNKYDIKKLKDNDANTYWQSSSIGPHTITIQFL
  31 .....MRKVDLC..SV.TEG.T.E.VILATSSDEKHPPENIIDGPA---W--RGRRGKSYSQTFH


           60             70        80          90           100       
           |              |         |           |             |       
   1 .KHVRIERLVI.....QSYFVQTLKIEKSTSKEPVDF..EQWIE..KDLVHTEGQ..LQ..NE..
   2 .RKTTVKTLCIya7sdESYTPSKISVRVGNNFHNLQE..IRQLE..--LVEPSGW..IH..VPlt
   3 .RKTTVKTLCIya7sdESYTPSKISVRVGNNFHNLQE..IRQLE..--LVEPSGW..IH..VPlt
   4 .RKTTVKTLCIya7sdESYTPSKISVRVGNNFHNLQE..IRQLE..--LVEPSGW..IH..VPlt
   5 .RKTTVKTLCIya7sdESYTPSKISVRVGNNFHNLQE..IRQLE..--LVEPSGW..IH..VPlt
   6 .KKVKLQLVVLyv7ldESYTPSKISIRAGDGFHNLKE..IKSVE..--LVKPTGW..VC..LSls
   7 .KKVKLQLVVLyv7ldESYTPSKISIRAGDGFHNLKD..IKSVE..--LVKPTGW..VC..LSls
   8 .RRTTVKMLCIya7sdESYTPSKISVRVGNNFHNLQE..IRQLE..--MVEPSGW..IH..ISlm
   9 .RKTTVKTLCIya7sdESYTPSKISVRVGNNFHNLQE..IRQLE..--LVEPSGW..IH..VPlt
  10 .KRTNISQIYIyt7ldESYTPSRISIRSGTNFNDLQE..LQVMD..--LTEPTGW..VQ..IPik
  11 .RKTTICDICIyt7ldESYTPSRISIRAGTNFNDLQE..IEVMD..--LNEPSGWviIP..IK..
  12 .KHVKIEKLVI.....QSYLVRTLRIEKTTSKEPLDF..EQWVE..KDLVHTEGQ..LQ..NE..
  13 .KKVQLQLVVVyv7ldESYTPSKISVRAGDGFHNLKE..IKTVE..--LSKPVGW..VH..ISls
  14 .RKTTVSQIYIys7ldESYTPSRISIRCGTHFNDLQE..VEVVD..--LCEPSGW..VC..IPi.
  15 .KHVKIEKLVI.....QSYLVRTLRTEKTTSKEPLDF..EQWVE..KDLVHTEGQ..LQ..NE..
  16 .KHVRIERLVI.....QSYFVQTLKIEKSTSKEPVDF..EQWIE..KDLVHTEGQ..LQ..NE..
  17 .KRMDICVMAIff7adESYAPSLVKVYAGHSPSDARF..YKMLE..--VRNVNGWvaLR..FL..
  18 .KRMDICVMAIff7adESYAPSLVKVYAGHSPSDARF..YKMLE..--VRNVNGWvaLR..FL..
  19 .KRMDICVMAIff7adESYAPSLVKVYAGHSPSDARF..YKMLE..--VRNVNGWvaLR..FL..
  20 .KRMDICVMAIff7adESYAPSLVKVYAGHSPSDARF..YKMLE..--VRNVNGWvaLR..FL..
  21 .KKTDVAFMMFyl7ndESYTPSKIQIKLGSSHQDIFF..RNA--..QSFNEPQGWcaID..IR..
  22 .KRVDIIQLAMyf7vdESYTSETLRIYAGHSPSDATY..YKTLE..--VRNVNGW..VKftFE..
  23 .RRVEIRAIRFyv7qdESYTPTHILWYAGTGHHDLM-..-QFGE..QGLVDPRGWqeIK..IE..
  24 .KRVSIKYVSMyl7ldESYTPSTLRISAGTGFQDLEI..VTTVQ..--VEEPTGW..VH..VPvg
  25 .KRVGIRDIRFfv7edESYTPTKVVFKAGTSENNLIE..FATMT..--MENPVGW..QQ..VPia
  26 .KFLKISKIYLll7ldESYTPHDITIHIGNDENHLELlcETFCDmnKYSLNEPFWflID..FE..
  27 .ESTNVSAVTI.....ESYNVKHLKLEKNTSQSASQF..ESITE..KEFEHVTGC..LQ..SN..
  28 .KHVRIERLVI.....QSYFVQTLKIEKTRLKSQLIL..SNGLK..KIWYTQRGS..FK..MK..
  29 .RVRYVQSVQLfl7qdDSYTPEKIGVRCGLTREDVRE..ISSVE..--LVEPEGL..LT..LS..
  30 .KLTKVSKIFLlf7ldESYTPCEILIKIGNDEHNLEY..LCT--..---------..--..--..
  31 sKKSGQWR---.....---------------------..-----..---------..--..--..


                      110          120       130       140         
                       |            |         |         |         
   1 ...E.....I....VAHDG..SA.TYLRFIIVSAFDHFASVHSVSAEGTVVSNLS.....S
   2 ...D.....N....HKKPT..RT.FMIQIAVLANHQNGRDTHMRQIKIYTPVEESsig..K
   3 ...D.....N....HKKPT..RT.FMIQIAVLANHQNGRDTHMRQIKIYTPVEESsig..K
   4 ...D.....N....HKKPT..RT.FMIQIAVLANHQNGRDTHMRQIKIYTPVEESsig..K
   5 ...D.....N....HKKPT..RT.FMIQIAVLANHQNGRDTHMRQIKIYTPVEESsig..K
   6 gt.D.....P....RETFV..NT.FMLQIAILSNHLNGRDTHIRQIKVYGPRPNPip6pf-
   7 gt.D.....P....RETFV..NT.FMLQIAILSNHLNGRDTHIRQIKVYGPRPNPip6pf-
   8 n..Q.....R....TNEPI..ST.FMIQIAVLANHQNGRDTHMRQIKVYTPVEESsig..K
   9 ...D.....N....HKKPT..RS.FMIQIAVLANHLNGRDTHMRQIKIYTPVEESsig..K
  10 ...D.....G....NVKSI..RT.FMLQIAVISNHQNGRDTHMRQIRIHAPVEGKhypl.-
  11 ...D.....I....NDRPI..RT.FMIQIAVISNHQNGRDTHMRQINVYSPTQDIlgppaS
  12 ...E.....I....VARDG..YA.TFLRFIIVSAFDHFASVHSISAEGLTVSSLP.....-
  13 ga.D.....P....RETFI..HT.FMLQISVLSNHLNGRDTHIRQIKIYGPRPNHvp6pf-
  14 ...K.....E....YEEML..MCtFMIQIAVISNHQNGRDTHMRQIRIHSPTEGSqypl.-
  15 ...E.....I....VARDG..YA.TFLRFIIVSAFDHFASVHSISAEGLTVSSLP.....-
  16 ...E.....I....VAHDG..SA.TYLRFIIVSAFDHFASVHSVSAEGTVVSNLS.....S
  17 ...D.....N....REDDQllKC.QFIRLLFPVNHENGKDTHLRGIRLYVPSNEPhqdt.-
  18 ...D.....N....REDDQllKC.QFIRLLFPVNHENGKDTHLRGIRLYVPSNEPhqdt.-
  19 ...D.....N....REDDQllKC.QFIRLLFPVNHENGKDTHLRGIRLYVPSNEPhqdt.-
  20 ...D.....N....REDDQllKC.QFIRLLFPVNHENGKDTHLRGIRLYVPSNEPhqdt.-
  21 ...D.....K....MERPQ..RV.FWIQIQVIQNHQNGRDTHIRHVRVLGPKRSRvsptnR
  22 ...D.....N....RPSDGllKC.QFLRIEVVTNHENGKDTHLRGIRMFGPGESLvnia.D
  23 ...G.....CggghDGNSL..CC.FIVQMHVKENHQNGKDTHIRGIKIYALDDNTpra..S
  24 ...D.....F....GRNGLl.DV.HLIQIKILANHQSGKDSHVRLIK--------.....-
  25 6ggD.....P....DGNTL..VA.WVVQMQILENHQNGKDTHLRGIKIYSFDNDSalg..P
  26 ...Kc15hlK....KKNHI..YC.RCLKISIISSQHNGKDTRIRQLQIYGPNYFHyky..D
  27 ...T.....V....PLNGI..DA.THLRFIITSGHDHFVSVHRVSVQL-------.....-
  28 ...K.....L....WHMMA..PL.LT-----------------------------.....-
  29 ...-.....-....VAR--..KC.IYILVVINSNHQEGKDSHVRHLKILESSTKEiyy..K
  30 ...-.....-....-----..--.-------------------------------.....-
  31 ...-.....-....-----..--.-------------------------------.....-