(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0209 IR47, H.influenzae
    • gi|23059005|ref|ZP_00084010.1|_4:221 COG1720: Uncharacterized conserved protein [Pseudomonas fluorescens PfO-1]
    • gi|23029953|ref|ZP_00068242.1|_2:217 COG1720: Uncharacterized conserved protein [Microbulbifer degradans 2-40]
    • gi|23050147|ref|ZP_00077111.1|_12:136 COG1720: Uncharacterized conserved protein [Methanosarcina barkeri]
    • gi|22968180|ref|ZP_00015770.1|_26:164 COG1720: Uncharacterized conserved protein [Rhodospirillum rubrum]
              10        20                30        40          50     
              |         |                 |         |           |     
   1 MNDLTLSPIAIIHTPYKEKFSVPRQ...PNLV.....EDGVGIVELLPPY..NSPEAVRGLEQFS
   2 -NDLTLSPIAIIHTPYKEKFSVPRQ...PNLV.....EDGVGIVELLPPY..NSPEAVRGLEQFS
   3 -NDLTLSPIAIIHTPYKEKFSVPRQ...PNLV.....EDGVGIVELLPPY..NSPEAVRGLEQFS
   4 -NDLTLSPIAIIHTPYKEKFSVPRQ...PNLV.....EDGVGIVELLPPY..NSPEAVRGLEQFS
   5 -SSFQFEQIGVIRSPYKEKFAVPRQ...PGLV.....KSANGELHLIAPY..NQADAVRGLEAFS
   6 -SSFQFEQIGVIRSPYKEKFAVPRQ...PGLV.....KSANGELHLIAPY..NQADAVRGLEAFS
   7 -SSFQFEQIGVIRSPYKEKFAVPRQ...PGLV.....KSANGELHLIASY..NQADAVRGLEAFS
   8 -SSFQFEQIGVIRSPYKEKFAVPRQ...PGLV.....KSACGELHLIAPY..NQADAVRGLEAFS
   9 -SSFQFEQIGVIRSPYKEKFAVPRQ...PGLV.....KSANGELHLIAPY..NQADAVRGLEAFS
  10 -TDFHFTQIGVIHSPYKEKFAVPRQ...PGLI.....EDGGGKLVLLPPY..NQPDAVRGLEQFS
  11 -SSFQFDQIGVIRSPYKEKFAVPRQ...PGLV.....KSACGELHLIAPY..NQADAVRGLEAFS
  12 -STFSFNQIGVIRSPYKEKFAVPRQ...PGLV.....EDGGGELQLLAPY..NQPESVRGLSDFS
  13 ---LTLNPIGIIHSPYDEKFSVPRQ...PNLV.....KEGKGILKLLPPY..NSPDAVRGIEQFS
  14 ---HTVTPIGIIRSCFKEKFAIPRQ...PQLA.....PAARGVLELLPPF..DQGDAVEGLEQVS
  15 ---LHLTPIAIIHTPYKEKFSVPRQ...ANLV.....QDGTGIVELLPPF..NCPEAVRGLEQFS
  16 ---HSVSPIGYIRSCFMEKFAIPRQ...PLLA.....PAARGTLELLPPF..DQVEALEGLEQVS
  17 -MQHTVVPVGIVHSCFKEKFAIPRQ...PQLA.....PAACGVLELLPPF..DQGDAVEGLEQVS
  18 -MTYSVSPIGFVRSCFKEKFAIPRQ...PQLA.....PAARGVLELVAPF..DQGDAVQGLEQVS
  19 ---LQLHAIGIIHTPYKEKFSVPRQ...PNLV.....QDGTGILELLPPY..NQAETVRGLAQFS
  20 ---HSVSPIGYIRSCFMEKFAIPRQ...PLLA.....PAARGTLELLPPF..DQVEALEGLEQVS
  21 -MSYNVSPVGFVRSCFKEKFAIPRQ...PQLA.....PAARGVLELVAPF..DQGEAVQGLEQVS
  22 --SYSIEPIGIIRSPYKEKFAVPRQ...PGLV.....PNACSEIILQGSA..NTIEAVRGIEQFS
  23 -MSHLVSPIGYLRSCFKEKFTIPRQ...PQLA.....PAARGVLELLPPF..DQGQAVEGLEQVS
  24 --SYNVSPVGFVRSCFKEKFAIPRQ...PQLA.....PAARGVLELVAPF..DQGEAVQGLEQVS
  25 --NYTFEPIGVIRSPYREKFGIPRQ...PSLV.....SAARMRLELSPPY..DHPDCVRGLAEFS
  26 ---LLTEPIGYLESCFPAKIGTPRQ...PSIC.....SHSRACLKIRKNIfnNPEHSLMGLEEFS
  27 ---LLTEPIGYLESCFPAKIGTPRQ...PSIC.....SHSRACLKIRKNIfnNPEHSLMGLEEFS
  28 ----SIDPIGFIESPYKEKFAVPRQ...PRLV.....PAARARVKLVGSA..NTPESVRGLAQFS
  29 ---LLTEPVGYLESCFSAKNGTPRQ...PSIC.....SYSRACLRIRKRIfnNPEHSLMGLEQFS
  30 ---LLTEPVGYLESCFSAKNGTPRQ...PSIC.....SYSRACLRIRKRIfnNPEHSLMGLEQFS
  31 -----ITAVATCRTPYKQKFGIPRQ...PGL-.....VKARGYVELEGHV..NHLDAVRGIEQYS
  32 ----SIDPIGFIESPYKEKFAVPRQ...PRLV.....PAATARVKLVGSA..NTPESVRGLAQFS
  33 ---YSIEPIGIIETPYKEKFAVPRQ...PRLV.....PAAKARIKLLGEA..NSPEAVRGLEQFS
  34 ----VLNPIGVIESPYDEKFSVPRQ...PNLV.....AQGKGNLTLFPPY..NCAEAVRGLAQFS
  35 ---FEFSAIGVVRTPFKDRFGVPRQ...PGLA.....AQAKGVIKINPDP..DLKTALRSLEEFT
  36 --TYTITPIGTARSPYKQKFGIARQ...PGLV.....SAAKACIELNPKF..-TADSVRGLEDFD
  37 ----PIEPIAIIESPYQEKFAVPRQ...PRLV.....PSATARVKLLGEC..NCAESIRGIEQFS
  38 --TYTIVPIATARSPYKQKFGIARQ...PGLV.....SAAEVCIELNPEF..-TADSVRGLEDFD
  39 --QFTLNAIGKIHTCYKQKFGIPRQ...AGLS.....PSAEARIEIFAPY..NRIEAFEELKQSS
  40 ----ELNIIARIRTDFPTKFGIPRQ...SGLI.....DDLKAAVVFEPEY..RNADALRGLEGFS
  41 ---IQTGPIGYISSCFSVKNATPRQ...PTIC.....GPSRAQLRIQQSVfnNPEHSLLGLEHYS
  42 --SHSISPIGHVRSCFKEKFAIPRQ...PQLA.....PAATGVLELLPPF..DTGDAVEGLEQVS
  43 ---IKLKPIGIISTCFPSKRATPRQ...TGVC.....GKVPGKLLLYNSIftNPDHALEGLQDFS
  44 ---CTFKPIGVIKTVFNEKRAVPRQ...ASLA.....TALLSRIDISPKTfnNPGHSLDGLENFS
  45 ---AHFRPIGVIRTAFPEKRAVPRQ...SIVG.....SRLRGIIQLNDGVftNPEHSLEGLEDFS
  46 ---AHFRPIGVIRTAFPEKRAVPRQ...SIVG.....SRLRGIIQLNDGVftNPEHSLEGLEDFS
  47 ------EPIGYLESCFKDKFGTPRQ...PGLV.....KRAEARLKIRADL..QPEESLQGLEGFS
  48 --QFFMKPIGYFRAEQIKKYQVPRQ...APL-.....SDSEGLIELLPQV..QFEQALTGLEGFE
  49 ---IKLTAIGTFKSPQVHPYEAGRQ...PDE-.....FHSQGVIELEPGH..NFEQALTGLEGCE
  50 ------PIIGYHHAPLSQKFGAPRQ...PNL-.....VALTSVIEMIAPY..DTPAAFIGLEDFS
  51 --IYPMRPIGTIQSCFSTRNGTPRQ...PLLV.....SLARACLIFDPAL..VPPASLEGLEEYS
  52 -------------------------...----.....-------------..-------------
  53 --MIEIPIIGRVNSCYNEKWGTPRQ...GKYG.....LSSLATIELNTNI..VCRDKLKDLEEHS
  54 --IYPMRPIGTIQSCFSTRNGTPRQ...PLLV.....SLARACLIFDPAL..VPPASLEGLEEYS
  55 -------------------------...----.....-------------..-----------FS
  56 --MICYRPIGIIHSPFKEPKDVPIQ...ASAA.....KDIEGTVEVFPEF..--SEGLKDIEEFS
  57 ---FPVRTIGYCYSCWTEKFGVPRQ...SVLV.....PSSRGVIQLLPEF..N-SDFIFGLDEFS
  58 ---FLLKQIGVIRSPFKSPSECPFQ...GRF-.....SQERFTIELFPEY..--EEGLKDIETCT
  59 ---LLTEPIGYLESCFSAKIGTPRQ...PSIC.....SQSRACLKIRKSIfnNPEHSLMGLEQFS
  60 ---FTYRPIGTLYSPYSRRIDAPHQ...GTVVeg6tgEPALATLELHEWL..-DESAIRDLSGFD
  61 -MSFKLIPIGYIR------------...----.....KGADTFIEILPEF..--LDAIEGLQDGD
  62 MMLVQLRQVGVIRSPYKNFSKAPHQ...GRF-.....SKETVEIEIFPEF..--EDGLKDIETCT
  63 --PFTVTPIGVLRTPHTSREGMPIQ...PTGA.....SACRGEARINPEL..--ADGLKDLEGFS
  64 -----LKPIGVVKSPFKTQNDAPRQ...GRF-.....SDAVSEIAIFDEY..--ADGLHKIENLR
  65 ---ILMKPIGYIKSPYKEKGEAPRQ...STLS.....GETTAVIEILEEY..--QEGIADIQEGE
  66 --SIELKSIGTIHTPYIPTLPIPEQ...PVQD.....APGEFWISLNPEY..--VEGLSELSSYR
  67 -SSFQFEQIGVIRSPYKEKFAVPRQ...PGLV.....KSQRRTASHCSLQ..QPTPFAAWKRSAI
  68 --EIRIRPVGVVRSPFKTRSDAPAQ...GRF-.....SSEESEIHIFPEY..--LDAVDGLELFS
  69 -----LVPIGVIHSPYKRKGEAPHQ...GRA-.....RNEEAILEIYPEF..--QEGLQEIEKKK
  70 -------------------------...----.....-------------..-------GLEQFS
  71 ---FSVQPIAFVHNERKE-----IK...DDEW.....GEVRSCITLTEMY..-TEESIQGIEDFS
  72 ----EMVPVGYVENDYLE----PVY...NEEV.....YSKVSKIVLKKEF..--TDGLYRIEDFE
  73 ---FSVQPIAFVHNERKE-----IK...DDEW.....GEVRSCITLTXMY..-TEESIQGIEDFS
  74 ---ASLFFVGKIRTPWKSRADTPRQ...GSE-.....SGPLCTLEISEPW..--AVALKGVEAYS
  75 ----GLVFIGRIRTPWTSRLETPRQ...GRH-.....DGPICRLEIFEPF..--VPAIKGVDFYS
  76 ----VLRPIGFVSHGLPDST---VR...ENI-.....GGVEGFIEVLPEY..--APGLDGLAGFS
  77 ---VSMVKIGEVQSSIDEKVYCNW-...----.....GSIISNIKIYPEY..--IGGLAGLEDYS
  78 ---ASLFFVGKIRTPWKSRSDTPRQ...GSE-.....LGPLCTLEISEPW..--AVALKGVEAYS
  79 ----EFTPIGYVENDYFK----PEY...KEEV.....YEKVSKIVLREDL..--VDGLYRVEELE
  80 -----VVFIGRIASPWTTRESCPKN...MRTAre...TGQQAVLTIDAPY..--REGLRGLERAS
  81 ----GLYFIGRVRTPWGSRAECPKN...GTQ-.....TDAVCTLEVDARY..--HGALQNLDGAT
  82 -----FEPIGYVRHQY------PDD...EVRR.....RAVDAVIEVLPQY..--EEGLRGIEEFS
  83 --VFSVQPIAFVHNERKE-----IK...DDEW.....GEVKSYITLTEMY..-TEESIQGIEDFS
  84 ----GLVFIGRIRTPWTSRGETPRQ...GSP-.....DGPVCRLEIFEPW..--TQALQGFDKFA
  85 -RMFSVQPIAFVHNERKE-----IK...DDEW.....GEVRSRITLTEMY..-AEKSIQGIEDFS
  86 ----EFTPIGYVENDYLE----PGH...NEEI.....YGKVSKIILRKDL..--EDGLYRVDELE
  87 ----ELSPIGYVRTRP---GRVPRS...WTT-.....SGVEGVLEVLPEY..--AEGLRDLREGE
  88 ------VPIGYIRK-----------...----.....TDRDVFIEILDEF..--LEGLEGLEEGM
  89 ----SVAFIGHIQTPWTSRDEAPRNvieARER.....STEPARITLDPAF..--APGLAGLAGHS
  90 ---VCFKYIGYIK----------RK...DNS-.....SSRQDIVEVIVDK..EYEEGLTGIEGFS
  91 ----GVVFIGRIHTPWNRLKECPRH...GRA-.....DGPVCRIEVFETW..--LPALAGIDDGT
  92 ---ICLKPIGVVE------VGMPRF...GKVDk....YSVVSVIRIYDEY..--VEGLTGLEEYS
  93 ---FSVQPIAFVHNERKE-----IK...DDEW.....GEVKSYITLTEMY..-TEESIQGIEDFS
  94 --SILMTPIGRVQGG----RTVPED...DDW-.....GDSRARIVLDPAR..FDDEALMGLDSFS
  95 ---YYLKPIGVVEQ-----------...----.....NENYTVLNIFDEF..--VEGLDGLKEGD
  96 ---FKIVPVGYIR------------...----.....KEKNVFIEILPEF..--REGMEGLREGD
  97 ---AELRFIGVVRSSLKDIGDCPKQ...GDE-.....GGVEAWVDIHEEY..--RAGLDSLRAGQ
  98 -----LTPIGWVVER----------...----.....TDEEGLVKVRERY..--RKCLEGLEGFS
  99 --CYSVGYLGIAYNVFRKRFESPRQ...PFIA.....HAGTELTRIVFTD..QGWERLLQLSALG
 100 ---YEVESIATVVGGHTR-----VQ...DDYQ.....GGVESVIRLNEAY..-SLETLQGIDEFS
 101 ----VLRPIGTVRSRLTRLDDCPKN...GDE-.....GAPEAWIDILPEF..--AAGLDTLEAGQ
 102 ---ACFKYIGFIK----------RN...DNS-.....TSRNAIIEIHVNK..EYEEGLKGLEEFS
 103 -------YIGIVREN----------...----.....KDGKGIIEIYKEY..--IQGLYKLEEFS
 104 -------EIGMFKK-----------...----.....EGENSYLEIYDEF..--LDGIDGLTKNS
 105 -------PIGYADTRFETAADAPRQ...GVE-.....TPYAANVQVYESF..--RGGLVGLEPDD
 106 --IYTIGPIGYIESAHMFSFTAAKR...SLA-.....ENTSQTLHFFPPY..-LPSIISRLSSTP


              60              70              80         90       100  
              |               |               |          |         |  
   1 .....HLWLIFQFDQI.....QQG.KWQ.....PTVRPPR.LG.GNQRVGVFASRATHRPNPLGL
   2 .....HLWLIFQFDQI.....QQG.KWQ.....PTVRPPR.LG.GNQRVGVFASRATHRPNPLGL
   3 .....HLWLIFQFDQI.....QQG.KWQ.....PTVRPPR.LG.GNQRVGVFASRATHRPNPLGL
   4 .....HLWLIFQFDQI.....QQG.KWQ.....PTVRPPR.LG.GNQRVGVFASRATHRPNPLGL
   5 .....HLWILFVFHQT.....MEG.GWR.....PTVRPPR.LG.GNTRMGVFATRSTFRPNPIGM
   6 .....HLWILFVFHQT.....MEG.GWR.....PTVRPPR.LG.GNARMGVFATRSTFRPNPIGM
   7 .....HLWILFVFHQT.....MEG.GWR.....PTVRPPR.LG.GNARMGVFATRSTFRPNPIGM
   8 .....HLWVLFVFHQT.....MDG.GWR.....PTVRPPR.LG.GNARMGVFATRSTFRPNPIGM
   9 .....HLWILFVFHQT.....MEG.GWR.....PTVRPPR.LG.GNARMGVFATRSTFRPNPIGM
  10 .....HLWVIFIFHQT.....IEG.GWK.....PMVRPPR.LG.GNAKMGVFATRSTFRPNPIGM
  11 .....HLWVLFVFHQT.....MDG.GWR.....PTVRPPR.LG.GNARMGVFATRSTFRPNPIGM
  12 .....HLWVIFVFHQT.....MEG.GWR.....PTVRPPR.LG.GNTRMGVFATRSTFRPNPIGM
  13 .....HLWLIFQFHQI.....PER.EWH.....ATVRPPR.LG.GNERIGVFASRATHRPNPIGL
  14 .....HVWLLFLFHQA.....LED.KPR.....LKVRPPR.LG.GNKSMGVFATRATHRPNGIGQ
  15 .....HLWLIFQFDNV.....PTG.KWQ.....PTVRPPR.LG.GNKRIGVFASRSTHRPNPLGL
  16 .....HVWLLFLFHQA.....LED.KPR.....LKVRPPR.LG.GNRSLGVFATRATHRPNGIGQ
  17 .....HVWLLFLFHQA.....LEE.KPR.....LKVRPPR.LG.GNKSMGVFATRATHRPNGIGQ
  18 .....HVWLLFLFHQA.....LED.KPR.....LKVRPPR.LG.GNKSMGVFATRATHRPNGIGQ
  19 .....HLWLIFQFDRV.....ATG.KWR.....PTVRPPR.LG.GNQRVGVFASRSTHRPNPLGL
  20 .....HVWLLFLFHQA.....LED.KPR.....LKVRPPR.LG.GNRSLGVFATRATHRPNGIGQ
  21 .....HVWLLFLFHLA.....LED.KPR.....LKVRPPR.LG.GNQSMGVFATRATHRPNGIGQ
  22 .....HLWLLFLFDQN.....LEA.GWR.....PTVRPPC.LG.GNERIGVFASRATFRPNGIGM
  23 .....HVWLLFLFHQA.....LEE.KPR.....LKVRPPR.LG.GNRSLGVFATRSTHRPNGIGQ
  24 .....HVWLLFLFHLT.....LED.KPR.....LKVRPPR.LG.GNQSMGVFATRATHRPNGIGQ
  25 .....HVWISFVFHQT.....MDR.GWQ.....PLVRPPR.LG.GNAKVGVFASRSTHRPNPMGL
  26 .....HVWILFVFHKN.....GHL.NYK.....AKVQPPR.LN.G-AKTGVFSTRSPHRPNAIGL
  27 .....HVWILFVFHKN.....GHL.NYK.....AKVQPPR.LN.G-AKTGVFSTRSPHRPNAIGL
  28 .....HVWLLFLFDQN.....LAA.GWK.....PTVRPPR.LG.GNERMGVFATRSTFRPNGIGM
  29 .....HVWILFVFHKN.....GHL.SCK.....AKVQPPR.LN.G-AKTGVFSTRSPHRPNAIGL
  30 .....HVWILFVFHKN.....GHL.SCK.....AKVQPPR.LN.G-AKTGVFSTRSPHRPNAIGL
  31 .....HLWLLFCFHEN.....LAQ.GWK.....TTVRPPR.LG.GNEKLGVFATRSTFRPNGIGQ
  32 .....HVWLLFLFDQN.....LAA.GWK.....PTVRPPR.LG.GNERMGVFATRSTFRPNGIGM
  33 .....HVWLLFLFDQN.....LEA.GWK.....PTVRPPR.LG.GNERIGVFASRSTFRPNGIGM
  34 .....HLWLIFQFHQL.....PAR.EWH.....STVRPPR.LG.GNQRIGVFASRATHRPNPIGL
  35 .....HIWIVFVFHDH.....GGK.GWK.....PSIRPPR.LG.GNRKVGVLASRSPHRPNPIGL
  36 .....YVWISFIFHGV.....LDE.GWA.....QMVRPPR.LG.GKQKMGVFATRSPHRPNHLGL
  37 .....HVWLLFLFDQN.....LAA.GWK.....PTVRPPR.LG.GNERVGVFASRATFRPNGIGM
  38 .....YVWISFIFHGV.....LDE.GWA.....QMVRPPR.LG.GKQKMGVFATRSPHRPNHLGL
  39 .....HIWVHFVFHEN.....RRT.EWK.....PKVKAPR.LG.GNKTIGVFATRSPVRPNPIGL
  40 .....HIWLIWEFSAA.....LRD.TWS.....PTVRPPR.LG.GNKRMGVFATRSPFRPNPLGL
  41 .....HIWVIFVFHKN.....GHL.NYK.....AKVKPPR.LD.G-KKTGVYSTRSPHRPNALGL
  42 .....HVWLIFLFHQA.....LED.KPR.....LKVRPPR.LG.GNQSMGVFATRATHRPNGLGQ
  43 .....HLWVLFYFHRN.....EST.HVR.....AKVAPPR.LN.G-TKTGVFSTRSPHRPCPIGL
  44 .....HLWIIYYFHRN.....PNH.-AK.....AKVAPPR.LG.G-ERVGVFSTRSPHRPCPIGL
  45 .....HLWLIYHFHRN.....-NS.HPK.....AKVAPPR.LG.G-ERVGVFSTRSPHRPCPIGL
  46 .....HLWLIYHFHRN.....-NS.HPK.....AKVAPPR.LG.G-ERVGVFSTRSPHRPCPIGL
  47 .....HVWLIWVFHQN.....KVA.RFH.....AKVHPPR.LG.G-ESMGLFATRTPHRPNPIGL
  48 .....RIWILFRFHLH.....--T.HWK.....PKVLPPR.--.GEKKQGVFATRSPHRPNLIGL
  49 .....RIWVVFLFHHN.....--D.HWS.....PMVLPPR.-G.GNTKQGVFATRSPYRPNPVGM
  50 .....HIWVSWQFHHNy10nkADS.SFR.....AQVRPPR.LG.GNQKIGVFASRSMYRPSALGL
  51 .....HCWILYVFHLNt10kpSQS.KLK.....AKVRVPR.LN.G-ERKGVFATRSPHRPCPIGL
  52 .....-----------.....---.KWQ.....PTVRPPR.LG.GNERIGVFASRATHRPNPLGL
  53 .....HTILIFIFNLN.....KIK.NSQk18qnAKVTPPK.ID.SGEKRGCLATRSPHRPVPIGL
  54 .....HCWILYVFHLNt10kpSQS.KLK.....AKVRVPR.LN.G-ERKGVFATRSPHRPCPIGL
  55 .....HIWVQFVFHGV.....AGA.GWQ.....PLVRPPR.LG.GNRKMGVFATRSPFRPNPLGL
  56 .....HIILIYHFHRA.....K--.-FK.....GLLVEPY.MH.E-EKHGVFATRAPARPNPIGI
  57 .....HLWIIFIFDDV.....PQDiTIN.....SKIRPPG.MN.G-KSTGVYSTRTPHRVNRIGI
  58 .....HLIVLYWLDRA.....NRD.--R.....LIAIPPF.--.DKREHGVFATRSPHRPNPIGF
  59 .....HVC--------.....QGR.LPK.....ACTQHVS.HL.ELPAIMVFFSR----------
  60 .....RLWLIFAFHLS.....--E.GWK.....SRVKPPR.--.GGPKRGVLATRAPHRPNAIGL
  61 .....WIKLILWFHKS.....DKP.ELRki...LKVHPYG.NP.KNPLRGVFATRSPYRPNPLAL
  62 .....HLIVLYWLDRA.....NRD.--A.....LLVVPPH.--.DSREHGVFATRSPHRPNPIGF
  63 .....HLILLYHFHES.....SGY.--D.....LTLTPFL.--.DTCKRGLFATRSPRRPCGIGL
  64 .....HIIVLYWMDKA.....SRD.--K.....LRVVPPG.--.ETEERGVFTTRSPSRPNPIGL
  65 .....YGVILFYFHKS.....EGY.--K.....LMTLSRR.--.NNQVMGVFSTRSPNRPNGIGL
  66 .....YITLLFYLDKV.....SEK.--S.....LKVNPSI.AP.E-LEVGVFASRSPRRPNPLGL
  67 .....YGSFSSFIKRW.....KAA.GVR.....LCVHRAS.AV.T-ARMGVFATRSTFRPNPIGM
  68 .....HIFVLYWLHLA.....ERN.---.....-VLRVVP.RG.KRKKRGVFSTRAPARPNPVGL
  69 .....HIIVLYWCHLG.....KRD.---.....-VIKTAT.PW.GPEIKGVFATRSPNRPNPIAF
  70 .....HVWILFVFHKN.....GHL.SCK.....AKVQPPR.LN.G-AKTGVFSTRSPHRPNAIGL
  71 .....HIEIVFYFHKV.....TDE.QIQ.....YVARHPR.NNhDYPKVGIFAQRGKNRPNRIGA
  72 .....KLYILFYFSKS.....KGY.---.....-KLIHRR.HY.DGEISGVFASRSPYRPNGIGL
  73 .....HIEIVFYFHKV.....TDE.QIQ.....YVARHPR.NNhDYPKVGIFAQRGKNRPNRIGA
  74 .....QLEVLYWLHQS.....PRD.---.....-IVLLSP.AD.DGEIHGAFSLRAPVRPNPIGT
  75 .....NLEVLYWLDKS.....RRD.---.....IILQSPK.NN.E-KTRGTFSLRSPVRPNPIGT
  76 .....HIIVIAYLHKS.....KGR.ALRvrprgLLRLGFR.LE.DLPEVGVFATDSPSRPNPLAL
  77 .....HAIVIFYMNDF.....QEE.NKH.....LWARKPRgLS.DFDEKGCFAQRTKHRPNPIGI
  78 .....RLEILYWLHES.....PRD.---.....-IVLLSP.AD.DGEIHGAFSLRAPVRPNPIGT
  79 .....KLYILFYFSKS.....EGY.---.....-KLIHRR.RY.DGEMSGVFASRSPYRPNGIGL
  80 .....HVIVLSWLHHA.....PRN.---.....LIVQKPR.HA.A-EAKGVFGLRSPARPNPIGL
  81 .....HLIVLYWMDRA.....ARD.---.....IVRQQPR.HA.D-GSRGTFSLRSPARPNPIAL
  82 .....HVIIIAHLHKH.....RGR.--P.....LVVRPKR.IE.GAPEVGVFSTDSPDRPNPIGI
  83 .....HIEVVFYFHKV.....TDE.QIQ.....YFARYPR.NNhDYPKVGIFAQRGKNRPNRIGA
  84 .....HAQVVYWLHMS.....RRD.---.....-LVIQRG.HG.IDGPRGTFALRSPLRPNPIGI
  85 .....HIEVVFYFHKV.....TDE.QIQ.....YFARHPR.NNkDYPEVGIFAQRGKNRPNRIGV
  86 .....KLYILFYFSKS.....KGY.---.....-KLIHRR.HY.DGEMSGVFASRSPFRPNGIGL
  87 .....RILVVFHFHQS.....PPF.GPE.....HLRQTPP.HR.E-GPVGVFSTCSPLRPNPVGV
  88 .....WIKVIAWLHKS.....DTW.EKRri...LKVHPRG.DK.RNPIRGVFATRSPVRPNPFGL
  89 .....HVVVLYWMDKA.....RRD.---.....LIVQCPR.HS.E-GPRGVFSLRSPLRPNPVAL
  90 .....HIILVYHLHLV.....NEY.---.....---RLIR.DR.DNIKIGVFATRSQFRPNPIGI
  91 .....LLEVFYWLHRS.....RRD.---.....LLLQCPR.ND.G-DARGTFSIRSPLRPNPIGT
  92 .....HAFILWYFHES.....RGA.--K.....LKLRPWG.RE.EMPEVGIFATRFPQRPNPLAL
  93 .....HIEVVFYFHKV.....TDE.QIQ.....YFARYPR.NNyDYPKVGIFAQRGKNRPNRIGA
  94 .....HAEIVYVFDKV.....GDD.QIV.....TGARHPR.GNkDWPRIGIFAQRGKNRPNRIGV
  95 .....YIIVLVWFHKN.....DSE.EKRki...LKVHPRG.DI.NNPLKGVFATRSPYRPNPIGK
  96 .....WIKLILWFHKS.....DTP.ELRri...LKVHPHG.NP.ENPLTGVFATRSPFRPNP---
  97 .....GLTLLTWLHEA.....DRS.--V.....LSVHPRG.DT.GRPRRGVFNTRSPARPNPVGL
  98 .....HVWILWWGHEA.....DRT.--V.....TRVRPVH.GE.VPELVGVFACRSPDRPNPVLL
  99 v15stPVYLLLHTHFN.....RNH.TFR.....CYIMPPR.--.QTHRVGLFSTRSPHRINPLGL
 100 .....HLTVTWRFHLA.....QPE.DVQ.....LHARSPR.GNvQWPATGTFVHRNHRRPNQLAV
 101 .....ELTLVTWLHLA.....DRD.--T.....LAVHPRG.DT.SRPMRGVFNTRSPARPNPLGL
 102 .....HIIVIYHLHLA.....SFD.---.....--GRLLR.EK.KGVTVGIFATRSQFRPNPIGI
 103 .....HIIVISWLNKV.....SEE.QRNtl8rgLLKYGFR.LE.DLPEVGVFCTDSPHRPNPIAI
 104 .....KILIFLWFNRS.....DEE.GKRkt...LMVHPRG.NV.KNPIRGVFSTRSPMRPNPIAL
 105 .....RVVVVWWADDA.....DRD.---.....--VLAVR.DG.D---RGVFTTRSPARPNPVCI
 106 .....MGYVRILYCFS.....KNY.TFR.....PKVPAPG.SV.S---VGLFSTRSPSRPNQIAM


           110          120       130         140         150          
            |            |         |           |           |          
   1 SKVELRQVEC.ING.N.IFLHLGAVDLVDGTPIFDIKPY..IAYADSEP.NAQ.SSFAQEKL...
   2 SKVELRQVEC.ING.N.IFLHLGAVDLVDGTPIFDIKPY..IAYADSEP.NAQ.SSFAQEKP...
   3 SKVKLHQVEC.ING.N.VFLHLGAVDLVDGTPIFDIKPY..IAYADSEP.NAQ.SSFAQEKP...
   4 SKVELRQVEC.ING.N.IFLHLGAVDLVDGTPIFDIKPY..IAYADSEP.NAQ.SSFAQEKL...
   5 SLVELKEVVC.HKD.S.VILKLGSLDLVDGTPVVDIKPY..LPFAESLP.DAS.ASYAQSAP...
   6 SLVELKEVVC.HKD.S.VILKLGSLDLVDGTPVVDIKPY..LPFAESLP.DAS.ASYAQSAP...
   7 SLVELKEVVC.HKG.S.VILKLGSLDLVDGTPVVDIKPY..LPFAESLP.DAS.ASYAQSAP...
   8 SLVALKGIEC.RKE.S.VILKLGSLDLVDGTPVVDIKPY..LPFAEALP.DAA.ASYAQQAP...
   9 SLVELKEVVC.HKD.C.VILKLGSLDLVDGTPVVDIKPY..LPFAESLP.DAS.ASYAQSAP...
  10 SLIELKGIEY.RKG.R.VILELGSLDLVDGTPVIDIKPY..LPFAECQP.HAM.AGFAQQAP...
  11 SLVALKGIEC.RKE.S.VILKLGSLDLVDGTPVVDIKPY..LPFAEALP.DAA.ASYAQQAP...
  12 SLIELKGVRC.QNG.E.VILALGSLDLVDGTPVIDIKPY..LPFAESQP.QAR.AGFAQSAP...
  13 SKVALESVEV.RNG.E.VLLKLGSVDLVNGTPILDIKPY..IAYADSEP.NAR.SGFAQTQP...
  14 SVVRLEGVE-.---.P.GRLLLSGIDLLDGTPVLDIKPY..VPYADSIP.GAS.NQMASQAP...
  15 SKVELREVEY.KNG.K.ILLHLGSVDLIDGTPILDIKPY..IAYADNEP.NAR.SGFAQEKP...
  16 SVVRLEGFE-.---.A.GRLWLSGIDLLDGTPVLDIKPY..VPYADAVA.DAR.NGIADAPP...
  17 SVVRLEGVE-.---.P.GRLLLSGIDLLDGTPVLDIKPY..VPYADSIA.GAS.NQMANAAP...
  18 SVVKLDKVE-.---.A.NRLLISGIDLLDGTPILDIKPY..VPYADIIT.DAS.NSIASAAP...
  19 SKVELRRVEC.QNG.K.VLLHLGAVDLVDGTPIFDIKPY..LAYADSEP.EAK.SGFAQEKP...
  20 SVVRLEGFE-.---.A.GRLWLSGIDLLDGTPVLDIKPY..VPYADAVA.DAR.NAIADAPP...
  21 SVVKLDKVE-.---.A.GRLWLSGIDLLDGTPVLDIKPY..VPYADVIA.EAT.NQIASSAP...
  22 SAVELKGIRQ.KGS.D.IIIELGGVDLVDGTPIIDIKPY..VPYSDSLP.QAQ.GGFAAEEP...
  23 SVVRLDKVD-.---.A.GRLWLSGIDLLDGTPVLDVKPY..VPYADCLP.QAH.NAIAETPP...
  24 SVVKLDKVE-.---.P.GRLWLSGIDLLDGTPVLDIKPY..VPYADAIA.DAT.NHIASAAP...
  25 SLVELLAVN-.VDN.G.VTLELAGADLLDGTPVLDIKPY..IPFVESRP.EAS.GGFVDGPP...
  26 TLAKLEKVE-.---.G.GAVYLSGVDMIDGTPVLDIKPY..IADYDSPQ.NLS.VHNDHHKL...
  27 TLAKLEKVE-.---.G.GAVYLSGVDMIDGTPVLDIKPY..IADYDSPQ.NLS.VHNDHHKL...
  28 SAVEMKGITK.QGD.Q.VYLDLGSVDLVDGTPIIDIKPY..IPYSDAIL.DAV.GGYAESEP...
  29 TLAKLEKVE-.---.G.GAIYLSGIDMIHGTPVLDIKPY..IAEYDSPQ.NVM.EPLADFNL...
  30 TLAKLEKVE-.---.G.GAIYLSGIDMIHGTPVLDIKPY..IAEYDSPQ.NVM.EPLADFNL...
  31 SVVKLHGVVQ.RKG.K.VCLEISGMDLVDGTPIIDIKPY..IPFSDSIE.GAV.GGMAQEAP...
  32 SAVEMKGITK.QGD.Q.VYLDLGSVDLVDGTPIIDIKPY..IPYSDAIS.DAV.GGYAESEP...
  33 SAVEVKGITK.KGD.Q.IYIDLGSVDLVDGTPIVDIKPY..IPYSDAIP.EAI.GGYAGEEP...
  34 SKVALEAIEI.HHG.K.AQLKLGSVDLVNGTPILDIKPY..IAYADSEP.EAI.LGFAQHKP...
  35 SAVVVEKIDFdAEG.G.PEIHIGGVDLVDGTPVLDIKPY..IAYADSIP.HAS.AGWASAPI...
  36 SLLKLERIE-.TGK.P.VRLYCSGADLLDGTPIVDIKPY..IPFVESKP.DAA.SGFVSGKP...
  37 SAVELKGVSK.EGD.Q.YYLELGSVDLVNGTPIIDIKPY..IPYSDSIT.DAQ.GGYAEQEP...
  38 SLLKLNRIE-.TGK.P.VRLYCSGADLLDGTPIVDIKPY..IPFVESKP.DAA.SGFVSGKP...
  39 SAVRLETIEH.SSK.G.LFLVIRGGDFLDGTPVVDIKPY..VPYCDKID.NAT.NGFAADAP...
  40 SSVRLDSIEL.DPElG.PILHVSGADLLDQTPIFDIKPY..LPYTDCHP.EAT.GGFIEPLV...
  41 TLAKLDKVV-.---.G.DTLYLSDIDMIDGTPVLDIKPY..IPDYDSPH.TRK.GSDPHLHD...
  42 SVVKLEKVE-.---.P.GRLWLSGIDLLDGTPVIDIKPY..VPYADIVP.DAH.NAIADAPP...
  43 SLVKITNIE-.---.N.HTIYFEGVDMVDQSPVLDIKPY..IPQYDSPS.CFE.KSRNRSQE...
  44 SLVQLDRVE-.---.D.SKVYFLGTDMVDGTPVLDIKPY..IPQYDVPV.NLK.EAEFLNSR...
  45 SLVEIEKIE-.---.N.ATISFFGTDMVDGTPVLDIKPY..IPHYDAPS.LSV.DSGTLDEN...
  46 SLVEIEKIE-.---.N.ATISFFGTDMVDGTPVLDIKPY..IPHYDAPS.LSV.DSGRTSVG...
  47 SLVELVRVE-.---.K.DGIVVAGADLVDGTPILDIKPY..LPEVEAIP.TAR.TGWPAEIA...
  48 SCVKLKKIC-.---.G.LKLYIVNHDLLEGTPILDIKPY..LNYADSFQ.CQK.QGWLDDLTaad
  49 SCVKVKSID-.---.K.LKIHVEGADLLHGSPILDIKPY..VAYADSFP.GVE.PAWLKNAE...
  50 SVVKLEHIEI.IEG.R.VLLIISGADMIDGTPVIDIKPY..VAYSDVLH.EAQ.SGFAPSAP...
  51 TVAKVEEIQ-.---.K.DKVLLSGVDLVDGTPVLDIKPY..LPYSDSIQ.GASvPNWVKEDC...
  52 SKVELREVEY.KNG.K.ILLHLGSVDLIDGTPILDIKPY..IAYADNEP.CAR.SGFAQEKP...
  53 TICNIVNIDL.F--.G.MKIQVGGVDIIDGTPIVEIFPY..SLNYSISR.NVI.HTPNWVKP...
  54 TVAKVEEIQ-.---.K.DKVLLSGVDLVDGTPVLDIKPY..LPYSDSIQ.GAS.VPNW----...
  55 SLLKLERIE-.TEG.G.VRLWCGGADLLDGTPVLDIKPY..LPFVEAQP.DAA.PGFAAVPP...
  56 SVVRLVERK-.---.G.NILRIRDVDILDGTPLLDIKPY..VPEFDVRE.NVR.IGWLEKNV...
  57 SNVKIESIS-.---.G.NRIFISGIDLLNGTPIIDIKPYhiCDIIDKEE.LLC.PRWVVDNI...
  58 SVVKLLEVR-.---.G.RELVVEGLDAVDGTPVVDIKPY..SSKIDCVE.NAR.IGWF----...
  59 LRVNSPKRIF.IPS.G.GAVYLSGIDMIHGTPVLDIKPY..IADYDSPQ.NLE.PQTKHHKL...
  60 SAVELVAVE-.---.G.RTLHLRGVDLLDGTPVLDIKPY..VPYADAFP.DAR.AGWID---...
  61 YTVKIREIS-.---.D.NRIYIDWIDADDGTPVVDIKIF..VERYDCPN.ESI.E-------...
  62 AVVELLERD-.---.G.RVLKVKGLDALDGTPVVDIKPY..SSTIDSVG.NAK.IGWFEEAN...
  63 SVVRLTAVH-.---.G.NVLELEGVDMLDNSPLVDIKPY..VPRFDTPQgDIR.CGWLEDTA...
  64 CVVEILEVE-.---.R.NRLKVRWLDALDGSPVIDIKKY..SPEIDCVN.---.--------...
  65 STVRFVKRE-.---.G.NRLFFEGVDMLDNTPVLDIKPY..I-------.---.--------...
  66 SVVELRGIE-.---.G.NEILISSIDAYNGTPLLDIKPY..IKSIDIKA.DAN.DGWMDTLP...
  67 SLVELKEVVC.HKD.S.VILKLGSLDLVDGTPVVDIKPY..LPFAESLP.DAS.AS------...
  68 CLVELLEC--.---.G.EILRVRGLDALDGSPVIDIKPY..YEDIDS--.---.--------...
  69 CVADLIKVE-.---.G.NKLYVKGVDALDKSPILDIKPY..VYELDS--.---.--------...
  70 TLAKLEKVE-.---.G.GAIYLSGIDMIHGTPVLDIKPY..IAEYDSPQ.NVM.EPLADFNL...
  71 TIVKVIKRE-.---.G.KSIIVEGLDAIDGTPILDIKPI..M-------.---.--------...
  72 TIVELLKVE-.---.G.NVLHVKGLDAINGTPVLDIKPY..IKETE---.---.--------...
  73 TIVKVIKRE-.---.G.KSIIVEGLDAIDGTPILDIKPI..M-------.---.--------...
  74 SIVKVERVS-.---.G.NSIVVRGLDCLDGTPLLDIKP-..--------.---.--------...
  75 SIVKLVGIE-.---.G.NAILVRGLDCLDNTPLIDIKP-..--------.---.--------...
  76 TIARLLDIE-.---.G.RRLRVSGLDLYDGTPVLDIKPY..TPSRRVED.LSL.PSWYKE--...
  77 TTVEILSID-.---.N.NVMTVQGLDANDRTAILDIKPY..IAAFDTRE.NAR.VPDWM---...
  78 SIVKVERVS-.---.G.NSIVVRGLDCLDGTPLLDIKP-..--------.---.--------...
  79 TLVELLKVE-.---.G.NVLYVKGLDAINGTPVLDIKPY..MKDLE---.---.--------...
  80 HVARLIGLDI.A--.A.GRIDLDAIDVLDGTPVIDIKPY..FASTDAIP.EAI.--------...
  81 AVVERLVIA-.---.E.GTISVRGLDCIDGTPLLDIKPY..YASTDSRP.EAT.--------...
  82 TIARLLKRE-.---.G.RILYVEGVDLFNETPVLDIKGF..SP------.---.--------...
  83 TIVKVIKRE-.---.G.KSIIVEGLDAIDGTPVLDIKPI..M-------.---.--------...
  84 SSVAVVGIE-.---.G.ATVLVRGLDCLDGTPLIDLKP-..--------.---.--------...
  85 TIVKVIKRE-.---.G.KSIIVEGLDAIDGTPILDIKPI..--------.---.--------...
  86 TIVEFLKVE-.---.G.NVLYVKGLDAINGTPVLDIKPY..IKKL----.---.--------...
  87 SVLEVLGVE-.---.G.RCVRVRGLDMLDGTPVLDIKPH..VAADPSHP.---.--------...
  88 YTVFIEKIE-.---.R.NKLYISWIDAYDNTPVLDIRPF..VERLDCPA.DIN.LE------...
  89 AAVPLLSVDI.A--.A.GVLTVGPLDCLNGTPLIDIKPY..YVSTDCHP.TA-.--------...
  90 SVCELVKRE-.---.G.NILYVRGVNAYDGTPVLDIKPY..D-------.---.--------...
  91 SIARVDRRD-.---.G.ANLFIRGLDCLDGTPLVDLKP-..--------.---.--------...
  92 TIVKIVEVD-.---.P.PRLRVMGLDAWSGSPVLDIKPY..DH------.---.--------...
  93 TIVKVIQRE-.---.G.KSIIVEGLDAIDGTPVLDIKPI..M-------.---.--------...
  94 TVCEIVSVA-.---.G.RVLEVRGLDAIDGTPVLDIKPV..M-------.---.--------...
  95 YTVKIHKIY-.---.R.NKIFIDKIDAYNETPIIDIKIF..SEKLDC--.---.--------...
  96 YTVKVHKIE-.---.G.NRIYIDWIDAEDGTPVSDIKIF..PERYDCPK.E--.--------...
  97 HEVRLTAVE-.---.D.GRLKVAPLEALDGTPVIDIKTS..FDQRSGTG.GAA.SHAA----...
  98 TLCRILEVR-.-PN.S.GELRVSGLDARAGSPVVDMKPY..LPGYDEPD.G--.--------...
  99 SIVKVESLD-.-SQ.L.RCLTVVGSDLLNGTPIVAVQLY..RQDIHDHP.TAR.AGWLDTDT...
 100 SYPRLLSVD-.---.G.RDLLVTDLDAVDGTPVIDLAPY..FH------.---.--------...
 101 HDVRLLGTAP.GPD.GmVRLLVAPLEALHGTPVVDIK--..--------.---.--------...
 102 SVAELIEIK-.---.G.NIVLAKGINAFNNTPVLDIKPL..SAV-----.---.--------...
 103 SIVRLIKRQ-.---.E.NLLHVEDLDLFEETPILDIKAF..TP-ARCPD.DVK.V-------...
 104 YTVNIEKIL-.---.G.NRIYIEEIDAFSETPLIDIKNY..SKEL----.---.--------...
 105 TPCELLAVD-.-AA.D.GTLAIRGVDMAHGSPVLDLKP-..--------.---.--------...
 106 SYAYISGSI-.-NP.E.GLLPVVGLDALHQSPILSVE--..--------.---.--------...


      160            170            180            190       200       
       |              |              |              |         |       
   1 PVK.....LTVEFTEQAKSAVKKREEK.....RPHLSR.....FIRQVLEQDPRPAYQQG..KPS
   2 PAK.....LTVEFTEQVKSAVKKREEK.....RPHLSR.....FIRQVLEQDPRPAYQQG..KPS
   3 PVK.....LTVEFTEQVKSAVKKREEK.....RPHLSR.....FIRQVLEQDPRPAYQQG..KPS
   4 PVK.....LTVEFTEQAKSAVKKREEK.....RPHLSR.....FIRQVLEQDPRPAYQQG..KPS
   5 AAE.....MAVCFTAEVEKQLLTLEKR.....YPQLTL.....FIREVLAQDPRPAYRKG..EET
   6 AAE.....MAVSFTAEVEKQLLTLEKR.....YPQLTL.....FIREVLAQDPRPAYRKG..EET
   7 AAE.....MAVSFTAEVEKQLLTLEKR.....YPQLTL.....FIREVLAQDPRPAYRKG..EET
   8 IAE.....MPVSFTAEVAQQLTTLERR.....YPQLRT.....FICDVLAQDPRPAYRKG..EET
   9 AAE.....MAVSFTAEVEKQLLTLEKR.....YPQLTL.....FIREVLAQDPRPAYRKG..EET
  10 STN.....MEVVFSPAAEQQLISIQNI.....YPNLRR.....FISQVLAQDPRPAYRRR..EQE
  11 IAE.....MPVSFTAEVAQQLTTLERR.....YPQLRT.....FICDVLAQDPRPAYRKG..EET
  12 DTE.....MQVCFSPAAEQQLAHHQQR.....YPHLRR.....FISQVLAQDPRPAYRKD..DNE
  13 PAK.....LEVEFSEQALQAVEFCRNFatfg.IEQPLT.....FIRHVIEQDPRPAYQQG..KAT
  14 AAI.....AVQWGDNALPQAREHALRL.....GEPLVE.....LIEQCLAQDPRPAYQVP..-PA
  15 KQE.....LRVEFSPEVQATLEKLEKK.....RPHLKR.....FIREVIQQDPRPAYQKG..KCF
  16 PGI.....AVEWSEQARRQAHEHGQRL.....RQPVAE.....LIEQCLAQDPRPAYQKP..EP-
  17 VAI.....AVQWADNALLQAREHALRL.....SEPLVE.....LIEQCLAQDPRPAYQIP..-PS
  18 HLI.....DVQWTDAALQQAQTHAQRL.....AEPLVE.....LIEQCLAQDPRPAYQTP..-MP
  19 ECT.....LQVIFSEQAQNALQKIEKK.....RPHFKR.....FITEVIAQDPRPAYQKM..QSL
  20 PGI.....AVEWSEQARRQAHEHGQRL.....RQPVAE.....LIEQCLAQDPRPAYQKP..EP-
  21 ALI.....PVQWQDAALLQAREHALRL.....SEPLVE.....LIEQCLAQDPRPAYQLP..AP-
  22 ETL.....PVEFTDTALKQLEM---DD.....NAYQQN.....VIREVLAQDPRPAYKKN..KVD
  23 LAI.....PVDWSEPARLQAQAHAARL.....GEPLVE.....LIGQCLAQDPRPAYQVP..EP-
  24 DLI.....PVRWQEAALQQAREHALRL.....NEPLVE.....LIEQCLAQDPRPAYQLP..T-P
  25 PQL.....RVEWSEAARRRLDQ--TDA.....PAGFAQ.....LVEQVLAQDPRPAYQDD..--P
  26 RAEa157dLRKLNSGDASQPSFKYFHS.....AEEAKR.....AIEAVLSADPRSVYRRK..LCE
  27 RAEa157dLRKLNSGDASQPSFKYFHS.....AEEAKR.....AIEAVLSADPRSVYRRK..LCE
  28 ERS.....LVIFSSEA--DALLATRPN.....GTLEKQ.....VIEQVLAQDPRPAYKKN..KPD
  29 QNNq167dLGQLSSQDVDQASFKYFQS.....AEEAKR.....AIEAVLSADPRSVYRRK..LCQ
  30 QNNq167dLGQLSSQDVGQASFKYFQS.....AEEAKR.....AIEAVLSADPRSVYRRK..LCQ
  31 KLI.....SVEFSDLADEQINTYSKQEa....YTDLAV.....LICGVLGQDPRPAYKKA..KDD
  32 ERS.....LVIFSSEA--DALLATRPN.....GTLEKQ.....VIEQVLAQDPRPAYKKN..KPD
  33 EKS.....NVTFSSQALAMLAK--RSD.....TQYVQS.....VIEQVLAQDPRPAYKKN..KPD
  34 PAM.....LSVEFTQQALQAINFCKNFakfg.ITQPLV.....FIQQLIEQDPRPAYQQG..KIT
  35 PRY.....PVIFSDEAENEILKRDPQG.....AQNLRA.....LIVDVMELDPRPAFQKR..QNP
  36 VEL.....EVVWQEN------IGAENL.....SANTKN.....LISQSIAQDPRPAYQN-..-IP
  37 QRM.....AVTFSDAARQMLQAHPEGK.....--IRQA.....VIREVLAQDPRPAYKKH..RAD
  38 VEL.....EVVWQEN------IGAENL.....SANTKN.....LISQSIAQDPRPAYQN-..-IP
  39 ATY.....AVQFDEETLSKIRAI---S.....IANLEP.....LIIETLQLNPAPQYQTA..DT-
  40 DHE.....LVVDFPEQWLN------SI.....PPQRRQ.....ALVRVLAHDPRPSYQKD..--P
  41 LLPs135pSPLAGSGESNKPKFRFLQS.....TEEAAA.....AIKGVLSADPRSVYRRN..RCR
  42 SSI.....AVHWSDEALRQAHEHGLRL.....CQPVRE.....LV---------------..---
  43 SNIn291lCVVFNDRALIQLNEILGTK.....INDQKI.....AIENVLREDPRSVYLRQ..RWG
  44 EAPd34ssLNVMFNANA----ESQLQE.....LQIEKN.....SIVDVLKADPRSVYLRT..KYG
  45 QAEm70vvASNRLSVTFNEHAEAQLKE.....LQVEKQ.....CIVDILEADPRSVYLRT..KYG
  46 PHEs52vvASNRLSVTFNEHAEAQLKE.....LQVEKQ.....CIVDILEADPRSVYLRT..KYG
  47 KNP.....ITVTFDDKAEQLLQEWQVRnp...DKALRE.....VIEETLKQDPRPVVYRG..FEE
  48 EVF.....SIQWSSQVLEQLQYLEKEW.....DCFLQA.....KITLRLQVNPFPSSNNRikLIK
  49 RFT.....IDYSVEAK-QELEWLELHQ.....VHQLRG.....FLQHQLEFEPDNSRKKRv.KPE
  50 HLL.....AVTVTEFAYEQFVQMIDNQ.....RIHNEAe28ldNIKALIAQDPRPAYRRT..EI-
  51 SLAva9dt----FSSSITSCWKLIEKKslyssADEFRS.....LITQVLSWDIRSMSQRN..KPQ
  52 EQE.....LRVEFSPEVQIVLAKLEKK.....RPHLSR.....FIREVIQQDPRPAYQKG..KNL
  53 EKNs23skLKKIETNIQFFDDGDSYRN.....FNKLRN.....FIVEILKIDPRSRYSKK..KTK
  54 ---.....-------------------.....------.....-----------------..---
  55 VPL.....EVAWADEI------SAASL.....PPPNRL.....LIEQSIAQDPRPAYQDT..--P
  56 HKL.....EKARDDGRFFSLNFN----.....------.....-----------------..---
  57 EGQ.....FKVSIPNEILNKLDKITEK.....NGL---.....-----------------..---
  58 ---.....-------------------.....------.....-----------------..---
  59 RAAg157dLRKLSSGGASQTSFKYFHS.....AEEAKC.....AIEAMLSADPRSVYRRK..LCE
  60 ---.....-------------------.....------.....-----------------..---
  61 ---.....----------------ERE.....VNIPKG.....RIIGELNIIPR----KS..DHL
  62 PQS.....-------------------.....------.....-----------------..---
  63 EQA.....QEMKSD-------------.....------.....-----------------..---
  64 ---.....-------------------.....------.....-----------------..---
  65 ---.....-------------------.....------.....-----------------..---
  66 ---.....-------------------.....------.....-----------------..---
  67 ---.....-------------------.....------.....-----------------..---
  68 ---.....-------------------.....------.....-----------------..---
  69 ---.....-------------------.....------.....-----------------..---
  70 Q--.....-------------------.....------.....-----------------..---
  71 ---.....-------------------.....------.....-----------------..---
  72 ---.....-------------------.....------.....-----------------..---
  73 ---.....-------------------.....------.....-----------------..---
  74 ---.....-------------------.....------.....-----------------..---
  75 ---.....-------------------.....------.....-----------------..---
  76 ---.....-------------------.....------.....-----------------..---
  77 ---.....-------------------.....------.....-----------------..---
  78 ---.....-------------------.....------.....-----------------..---
  79 ---.....-------------------.....------.....-----------------..---
  80 ---.....-------------------.....------.....-----------------..---
  81 ---.....-------------------.....------.....-----------------..---
  82 ---.....-------------------.....------.....-----------------..---
  83 ---.....-------------------.....------.....-----------------..---
  84 ---.....-------------------.....------.....-----------------..---
  85 ---.....-------------------.....------.....-----------------..---
  86 ---.....-------------------.....------.....-----------------..---
  87 ---.....-------------------.....------.....-----------------..---
  88 ---.....-------------------.....------.....-----------------..---
  89 ---.....-------------------.....------.....-----------------..---
  90 ---.....-------------------.....------.....-----------------..---
  91 ---.....-------------------.....------.....-----------------..---
  92 ---.....-------------------.....------.....-----------------..---
  93 ---.....-------------------.....------.....-----------------..---
  94 ---.....-------------------.....------.....-----------------..---
  95 ---.....-------------------.....------.....-----------------..---
  96 ---.....-------------------.....------.....-----------------..---
  97 ---.....-------------------.....------.....-----------------..---
  98 ---.....-------------------.....------.....-----------------..---
  99 LYP.....LY-----------------.....------.....-----------------..---
 100 ---.....-------------------.....------.....------EMGPRGSLRQP..AWP
 101 ---.....-------------------.....------.....-----------------..---
 102 ---.....-------------------.....------.....-----------------..---
 103 ---.....-------------------.....------.....-----------------..---
 104 ---.....-------------------.....------.....-----------------..---
 105 ---.....-------------------.....------.....-----------------..---
 106 ---.....-------------------.....------.....-----------------..---


                  210       220         230         
                   |         |           |         
   1 .....DRI.....YGMSLYEFNVKWRI..KAGTVNCVEVIEIEKDK
   2 .....DRI.....YGMSLYEFNVKWRI..KAGTVNCVEVIEIEKDK
   3 .....NRI.....YGMSLYEFNVKWRI..KAGTLDCVEVIEIEKDK
   4 .....DRI.....YGMSLYEFNVKWRI..KAGTVNCVEVIEIEKDK
   5 .....GKT.....YAVWLHDFNVRWRV..TDAGFEVF---------
   6 .....GKT.....YAVWLHDFNVRWRV..TDAGFEVF---------
   7 .....GKT.....YAVWLHDFNVRWRV..TDAGFEVF---------
   8 .....GKT.....YAVWLHDFNVRWRV..VNSGFEVF---------
   9 .....GKT.....YAVWLHDFNVRWRV..TDAGFEVF---------
  10 .....NRE.....YAAHLLDFNVRWKI..CGTLTEVV---------
  11 .....GKT.....YAVWLHDFNVRWRV..VNTGFEVF---------
  12 .....SRE.....YAVLLLEFNVRWRV..IGQQTEV----------
  13 .....ERI.....YGMNLAGYNIRWQI..CTNNVNKAIVLDIEN--
  14 .....ERV.....YGVKFWDVQVRWHY..PQPDV------------
  15 .....HKI.....YGIALYEFNIRWRI..KNDDFTVAEVIEI----
  16 .....GRR.....YGVRLWDLDVHWHY..PRPDL------------
  17 .....ERV.....YGVKFWDVQVRWHY..PQPDV------------
  18 .....ERE.....YGAQFWDLDVRWHY..PT---------------
  19 .....ERV.....YGIRLHEFNIRWKM..EATEEQQARILDIE---
  20 .....GRR.....YGVRLWDLDVHWHY..PRPDL------------
  21 .....ERR.....YGARFWDVDVRWHY..PQAGVI-----------
  22 .....TKE.....YAVHLFNFNVKFTV..QDGLVTVT---------
  23 .....SRR.....YGVRFWDVEVRWHY..PRP--------------
  24 .....ERR.....YGAQFWDLDVRWHY..PQAGVI-----------
  25 .....ERV.....YGVTLYCYNVRFGI..ADGVARVLEI-------
  26 .....DRL.....FFFTVDTAHVTCWF..GDGFAEVVRI-------
  27 .....DRL.....FFFTVDTAHVTCWF..GDGFAEVVRI-------
  28 .....EKE.....YAVNLFDLNVKFII..QDKIVTVS---------
  29 .....DRL.....FYFTVDIAHVTCWF..GDGFAEVLRI-------
  30 .....DRL.....FYFTVDIAHVTCWF..GDGFAEVLRI-------
  31 .....PKL.....YQVALYDLDIFWRMavDGDDREYIQVLELKP--
  32 .....EKE.....YAVNLFDLNVKFII..QDKIVTVS---------
  33 .....TKE.....YAVNLFDLNVKFSV..NSNLITVT---------
  34 .....SRI.....YGMRLAGYNIRWQI..CESDPN-----------
  35 vt7swGQR.....YGIDVLGNDVKYEL..RESGLYVYDIQD-----
  36 .....ERI.....YVMNIADYEVRFQI..EENRATVI---------
  37 .....DKL.....YAVNLYDWNVKFTV..NAEA-------------
  38 .....ERI.....YVMNIADYEIRFQI..EENRATVI---------
  39 .....SKT.....YALRLFDYDIHWQL..-----------------
  40 .....QRI.....YGLEFAGFEIKFTV..LDKVLTVCEV-------
  41 .....DKL.....FFFTLDTAHITCWF..GEGFAEVL---------
  42 .....---.....--------------..-----------------
  43 .....SQF.....YTFLIHDLHITCRF..DDNHGIV----------
  44 .....SQI.....YTFQLGDHTVTCKF..DDQNTTVT---------
  45 .....SQI.....FTFQLREVTVTCKF..DDKAGTVT---------
  46 .....SQI.....FTFQLREVTVTCKF..DDKAGTVT---------
  47 .....GDSpyrssHAVRLYDVDVHFKF..ESP--------------
  48 .....GNN.....YQLAYQTWRVNYSI..DNSILLVFSL-------
  49 .....GSG.....FVIAYRTWRARFEI..QGHHVSVIRI-------
  50 .....HML.....FVMRYKSVDVSFQL..IDS--------------
  51 .....DTLdeeivYHLVLEGLDVSYMI..DNESNILVQDVSL----
  52 .....HKI.....YGMALYEFNVRWRI..KHDDVTVAEVIEI----
  53 .....LTL.....FGIKLF--------..-----------------
  54 .....---.....--------------..-----------------
  55 .....QRV.....YKMAVDDWEVAFRI..EKGMALI----------
  56 .....---.....--------------..-----------------
  57 .....---.....--------------..-----------------
  58 .....---.....--------------..-----------------
  59 .....DRL.....FFFTVDIAHVTCWF..GDGFAEVLRI-------
  60 .....---.....--------------..-----------------
  61 .....DEL.....EEVSPDEFDAVIIE..LGNKTTVLSA-------
  62 .....---.....--------------..-----------------
  63 .....---.....--------------..-----------------
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 100 .....GEM.....LADY----------..-----------------
 101 .....---.....--------------..-----------------
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