(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html
Citations (SAM, SAM-T99, HMMs)
- R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
- K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
- A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
Sequence numbers correspond to the following labels:
-
- T0193 AT-rich DNA binding protein (ATBP), T. aquaticus
-
- gi|4557113|gb|AAD22519.1|AF061257_1_1:211 (AF061257) AT-rich DNA-binding protein p25 [Thermus aquaticus]
-
- gi|15900958|ref|NP_345562.1|_6:211 (NC_003028) conserved hypothetical protein [Streptococcus pneumoniae TIGR4]
- gi|14972565|gb|AAK75202.1| (AE007410) conserved hypothetical protein [Streptococcus pneumoniae TIGR4]
-
- gi|15903042|ref|NP_358592.1|_6:211 (NC_003098) Conserved hypothetical protein [Streptococcus pneumoniae R6]
- gi|15458613|gb|AAK99802.1| (AE008472) Conserved hypothetical protein [Streptococcus pneumoniae R6]
-
- gi|20807044|ref|NP_622215.1|_7:217 (NC_003869) AT-rich DNA-binding protein [Thermoanaerobacter tengcongensis]
- gi|20515531|gb|AAM23819.1| (AE013024) AT-rich DNA-binding protein [Thermoanaerobacter tengcongensis]
-
- gi|15613114|ref|NP_241417.1|_6:208 (NC_002570) DNA-binding protein [Bacillus halodurans]
- gi|4514349|dbj|BAA75386.1| (AB013375) YdiH [Bacillus halodurans]
- gi|10173164|dbj|BAB04270.1| (AP001508) DNA-binding protein [Bacillus halodurans]
-
- gi|15675100|ref|NP_269274.1|_5:210 (NC_002737) conserved hypothetical protein [Streptococcus pyogenes] [Streptococcus pyogenes M1 GAS]
- gi|19746069|ref|NP_607205.1| (NC_003485) conserved hypothetical protein [Streptococcus pyogenes MGAS8232]
- gi|21910315|ref|NP_664583.1| (NC_004070) conserved hypothetical protein [Streptococcus pyogenes MGAS315]
- gi|13622257|gb|AAK33995.1| (AE006554) conserved hypothetical protein [Streptococcus pyogenes M1 GAS]
- gi|19748239|gb|AAL97704.1| (AE010034) conserved hypothetical protein [Streptococcus pyogenes MGAS8232]
- gi|21904511|gb|AAM79386.1| (AE014152) conserved hypothetical protein [Streptococcus pyogenes MGAS315]
-
- gi|16801243|ref|NP_471511.1|_6:210 (NC_003212) similar to a putative DNA binding proteins [Listeria innocua]
- gi|16804111|ref|NP_465596.1| (NC_003210) similar to a putative DNA binding proteins [Listeria monocytogenes EGD-e]
- gi|16411542|emb|CAD00150.1| (AL591982) similar to a putative DNA binding proteins [Listeria monocytogenes]
- gi|16414691|emb|CAC97407.1| (AL596171) similar to a putative DNA binding proteins [Listeria innocua]
-
- gi|15895970|ref|NP_349319.1|_5:207 (NC_003030) AT-rich DNA-binding protein [Clostridium acetobutylicum]
- gi|15025747|gb|AAK80659.1|AE007769_1 (AE007769) AT-rich DNA-binding protein [Clostridium acetobutylicum]
-
- gi|15925036|ref|NP_372570.1|_5:208 (NC_002758) conserved hypothetical protein [Staphylococcus aureus subsp. aureus Mu50]
- gi|15927621|ref|NP_375154.1| (NC_002745) conserved hypothetical protein [Staphylococcus aureus subsp. aureus N315]
- gi|21283699|ref|NP_646787.1| (NC_003923) conserved hypothetical protein [Staphylococcus aureus subsp. aureus MW2]
- gi|13701840|dbj|BAB43133.1| (AP003135) conserved hypothetical protein [Staphylococcus aureus subsp. aureus N315]
- gi|14247819|dbj|BAB58208.1| (AP003364) conserved hypothetical protein [Staphylococcus aureus subsp. aureus Mu50]
- gi|21205141|dbj|BAB95835.1| (AP004829) conserved hypothetical protein [Staphylococcus aureus subsp. aureus MW2]
-
- gi|21398209|ref|NP_654194.1|_4:206 (NC_003995) Octopine_DH_N, NAD/NADP octopine/nopaline dehydrogenase, NAD binding domain [Bacillus anthracis A2012] [Bacillus anthracis str. A2012]
-
- gi|18311284|ref|NP_563218.1|_5:209 (NC_003366) conserved hypothetical protein [Clostridium perfringens]
- gi|18145967|dbj|BAB82008.1| (AP003193) conserved hypothetical protein [Clostridium perfringens str. 13]
-
- gi|16077664|ref|NP_388478.1|_6:212 (NC_000964) ydiH [Bacillus subtilis]
- gi|7474965|pir||A69787 hypothetical protein ydiH - Bacillus subtilis
- gi|1945113|dbj|BAA19721.1| (D88802) ydiH [Bacillus subtilis]
- gi|2632910|emb|CAB12416.1| (Z99107) ydiH [Bacillus subtilis]
-
- gi|21221751|ref|NP_627530.1|_14:213 (NC_003888) conserved hypothetical protein [Streptomyces coelicolor A3(2)]
- gi|7480641|pir||T36268 probable DNA-binding protein - Streptomyces coelicolor
- gi|5123665|emb|CAB45354.1| (AL079345) conserved hypothetical protein [Streptomyces coelicolor A3(2)]
-
- gi|15805963|ref|NP_294663.1|_5:227 (NC_001263) conserved hypothetical protein [Deinococcus radiodurans]
- gi|7471300|pir||A75458 conserved hypothetical protein - Deinococcus radiodurans (strain R1)
- gi|6458662|gb|AAF10515.1|AE001946_7 (AE001946) conserved hypothetical protein [Deinococcus radiodurans]
-
- gi|15642943|ref|NP_227984.1|_3:202 (NC_000853) conserved hypothetical protein [Thermotoga maritima]
- gi|7462325|pir||G72408 conserved hypothetical protein - Thermotoga maritima (strain MSB8)
- gi|4980664|gb|AAD35262.1|AE001702_2 (AE001702) conserved hypothetical protein [Thermotoga maritima]
-
- gi|15217135|gb|AAK92526.1|AF401045_2_6:204 (AF401045) LaaK [Lactobacillus sakei]
-
- gi|15644178|ref|NP_229227.1|_5:202 (NC_000853) conserved hypothetical protein [Thermotoga maritima]
- gi|7462335|pir||H72256 conserved hypothetical protein - Thermotoga maritima (strain MSB8)
- gi|4981991|gb|AAD36497.1|AE001794_13 (AE001794) conserved hypothetical protein [Thermotoga maritima]
-
- gi|15673042|ref|NP_267216.1|_8:176 (NC_002662) HYPOTHETICAL PROTEIN [Lactococcus lactis subsp. lactis]
- gi|12724014|gb|AAK05158.1|AE006339_1 (AE006339) HYPOTHETICAL PROTEIN [Lactococcus lactis subsp. lactis]
-
- gi|18253153|dbj|BAB83964.1|_2:137 (AB066353) conserved hypothetical protein [Streptococcus suis]
10 20 30 40 50 60
| | | | | |
1 MKVPEAAISRLITYLRILEELEAQGVHRTSSEQLGELAQVTAFQVRKDLSYFGSYGTRGVGYTVP
2 MKVPEAAISRLITYLRILEELEAQGVHRTSSEQLGELAQVTAFQVRKDLSYFGSYGTRGVGYTVP
3 FAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIGIDSATVRRDFSYFGELGRRGFGYDVK
4 FAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIGIDSATVRRDFSYFGELGRRGFGYDVK
5 --VSMAVIRRLPRYHRCLEELLKNDIKRISSKELSERMGVTASQIRQDLNNFGGFGQQGYGYNVE
6 TKIPQATAKRLPLYYRFLENLHASGKQRVSSSELSEAVKVDSATIRRDFSYFGALGKKGYGYNVN
7 KSIPKATAKRLSLYYRIFKRFHADQVEKASSKQIADAMGIDSATVRRDFSYFGELGRRGFGYDVT
8 TKIPQATAKRLPLYHRYLKYLDESGKERVSSAELSEAVKVDSATIRRDFSYFGALGKKGYGYNVS
9 KNISMAVIRRLPKYHRYLEELLKSDVDRISSKELSEKIGFTASQIRQDLNCFGDFGQQGYGYNVK
10 VKIPRATLKRLPLYYRFVSSLKSKGIDRVNSKAISDALQIDSATIRRDFSYFGELGKKGYGYNID
11 QKIPQATAKRLPLYYRFIQNLSLSGKQRVSSAELSEAVKVDSATIRRDFSYFGALGKKGYGYNVN
12 KGISMAVIKRLPKYHRYLQELMENDVDRISSKELSEKIGFTASQIRQDLNCFGDFGQQGYGYNVK
13 SKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVKVDSATIRRDFSYFGALGKKGYGYNVD
14 RGIPEATVARLPLYLRALTALSERSVPTVSSEELAAAAGVNSAKLRKDFSYLGSYGTRGVGYDVE
15 ADIPTATVGRVVTYIRVLEELEAQNVLRASSGELARRAGVTPFQVRKDLTYFGRFGTRGIGYTVA
16 EKIPKPVSKRLVSYYMCLERLLDEGVEVVSSEELARRLDLKASQIRKDLSYFGEFGKRGVGYNVE
17 HDLPEAVAKRIPIYYRYFKLLETDGIERIKSEQLAKLVAIPSATIRRDFSYIGDLGRSGYGYEVS
18 IHLPRSTFERLKMYRKVLE---ATKKPYISSDEIARFLEINPDLVRKDFSYLNCQGKPRVGYDVE
19 KSLPKATAKRLPQYYRLFKSLVEENVTRTNSQLISEKIGVDAATIRRDFSLFGELGRRGYGYETK
20 -----------------------------------------------------------------
70 80 90 100 110 120
| | | | | |
1 VLKRELRHILGLNRKWGLCIVGMGRLGSALADYPGF.GESFELRGFFDVD..PE..KVGRP.VRG
2 VLKRELRHILGLNRKWGLCIVGMGRLGSALADYPGF.GESFELRGFFDVD..PE..KVGRP.VRG
3 KLMTFFADLLNDNSITNVMLVGIGNMGHALLHYRFHeRNKMKIIMAFDLDdhPE..VGTQT.PDG
4 KLMTFFADLLNDNSITNVMLVGIGNMGHALLHYRFHeRNKMKIIMAFDLDdhPE..VGTQT.PDG
5 ELYNNLTKILGLDKTYNTIIIGAGNLGQAIANYTRFeKSGFNLKGIFDIN..PR..LFGLK.IRD
6 YLLTFFRKTLHQDELTKVMLIGVGNLGTALLNYNFSkNNHTQIVMAFDVD..RE..KIGNT.VSG
7 KLMNFFADLLNDHSTTNVILVGCGNIGRALLHYRFHdRNKMQIAMGFDTD..DNalVGTKT.ADN
8 YILDFFSKTLSQDKQTNVALIGVGNLGTALLHYNFMkNNNIKIVAAFDVD..PA..KVGSV.QQD
9 DLSREVDNILGLTKMYNTIIIGAGNIGQAIANYINFqKMGFDLKAIFDIN..PK..LIGLK.IQD
10 SLLDFFKSELSESDMIKIAIVGVGNLGKALLTYNFSiHDDMTITEAFDVK..ED..VIGQK.IGN
11 YLLSFFRETLDQDDITRVALIGVGNLGTAFLHYNFTkNNNTKIEMAFDVS..EE..KVGTE.IGG
12 ELYNNIGSILGLTRDYNTVIIGAGNIGQAIANYNSFnRLGFKLKGIFDAN..PR..MFGIK.IRD
13 YLLSFFRKTLDQDEMTDVILIGVGNLGTAFLHYNFTkNNNTKISMAFDIN..ES..KIGTE.VGG
14 YLVYQISRELGLTQDWPVVIVGIGNLGAALANYGGFaSRGFRVAALIDAD..PG..MAGKP.VAG
15 VLRRELLRALGLDQTWNVVIVGMGRLGHAIANYPGAsDYQFQNVGLFDVA..PD..VVGRE.VRG
16 HLYDAIGEILGVKKEWKLVVVGAGNIGRAVANYTVMkEKGFRIIGIFDSD..PS..KIGKEaAPG
17 HLIQIFSAVLKADILTKMAVIGVGNLGRALIENNFRrNDNLQITCAFDTN..PA..LVGQT.LNG
18 ELRKELDDLFGVNNTTNMIIVGANDLARALLSLDFS.KAGVKVVAVFDTE..RE..NVGKF.IGE
19 VLRDFFGELLGQDQETHIALIGVGNLGRALLHYQFQdRNKMRITQAYDIS..GNplVGTQT.DDG
20 ---DFFADILNDTSITNVMLVGVGNMGRALLHYRFHeRNKMKIVMAFEAD..DNp.AVGTT.DEN
130 140 150 160 170 180
| | | | | |
1 GVIEHVDLLPQRV.....PG.RIEIALLTVPREAAQKAADLLVAAGIKGILNFAPVVLEVPK...
2 GVIEHVDLLPQRV.....PG.RIEIALLTVPREAAQKAADLLVAAGIKGILNFAPVVLEVPK...
3 IPIYGISQIKDKI.....KDaDVKTAILTVPSVKSQEVANLLVDAGVKGILSFSPVHLHLPK...
4 IPIYGISQIKDKI.....KDtDVKTAILTVPSVKSQEVANLLVDAGVKGILSFSPVHLHLPK...
5 VEVMDVEKVEEFI.....ANnHIDIAILCIPKDNAQYTADRLVKAGIKAIWNFSPIDLKVPD...
6 VKIENLDNLENKI.....TS.DVSVAILTVPAAVAQKTADRLVNAGVKGILNFTPARIAVPE...
7 IPVHGISSVKERI.....ANtDIETAILTVPSIHAQEVTDQLIEAGIKGILSFAPVHLQVPK...
8 IPIYHLNDMEEIV.....REnGVEVVILTVPADEAQVTVDRLIEADVKGILNFTPARISVPK...
9 VEVRDVDNIDGFL.....QKnKIDIGIICVPSKNAQKVCDIIVKNNVNGIWNFAPVDLMTPE...
10 VIVKDNDELITTL.....KKeEIDVVILTTPERVAQKVADELVQAGVKGILNFTPGRINTPS...
11 IPVYHLDELEERL.....SS.DIQVAILTVPATVAQSVADRLAETNVHGILNFTPARLNVSD...
12 VEIQDVEKLKDFV.....KEnDIEIGIICVPRTNAQKVCNDLVEGGIKGIWNFAPIDLEVPK...
13 VPVYNLDDLEQHV.....KDe--SVAILTVPAVAAQSITDRLVALGIKGILNFTPARLNVPE...
14 IPVQHTDELEKII.....QDdGVSIGVIATPAGAAQQVCDRLVAAGVTSILNFAPTVLNVPE...
15 LTIQHMSQLGPFVas6gtPR.QVDMGLLTVPAEHAQAAAQALVAAGVGGILNFAPVVLQTQDl13
16 LTVSDVSELEKFV.....EEhGVEIGVIAVPAEHAQEIAERLEKAGIKGILNFAPVKIKV--...
17 VPIYAIDQLATVI.....PAaGITTAISTVPSEASQRSAEQLIDAGITSILNFAPTRLQVPR...
18 FAVRELDVLERVI.....RRfDAEIAALCVSKDRAQATAEFLIEKGIKAVWNFTGVHLDLPE...
19 IPIYNISDLEKNV.....KKsDIKTAILSVRKENAQEVVDTLVKAGI---------------...
20 IPIHAISEIKERI.....SEaNSQTAILTVPSVKAQEVTDILVEAGVKGILSFSPVNLSVPK...
190 200 210
| | |
1 ..EVAVENVDFLAGLTRLSFAILNPKWREEMMG
2 ..EVAVENVDFLAGLTRLSFAILNPKWREEMMG
3 ..DVVVQYVDLTSELQTLLYFMRK---------
4 ..DVVVQYVDLTSELQTLLYFMRK---------
5 ..DVILENVHLSDSLFTISYRLNEEELFKKLKG
6 ..HVRVHHIDLSVELQALIYFLKH---------
7 ..GVIVQSVDLTSELQTLLYFMNQ---------
8 ..QVRVHHIDLTTELQTLIYFLENY--------
9 ..NVIVENVHLSESLLTLSCLLQ----------
10 ..DVQVHQIDLGIELQSLLFFMKN---------
11 ..NIRIHHIDLAVELQTLVYFLKN---------
12 ..DIRVENVHLSESMMTLVYLLNHN--------
13 ..HIRIHHIDLAVELQSLVYFLKHYSVLE----
14 ..GVDVRKVDLSIELQILAF-------------
15 rrEVTVENVDFLAGMKRLAFYMLGP--------
16 ..SVPVENIDITASLRVLTFE------------
17 ..HINVRYLDLTAELQTLL--------------
18 ..GVIVVEEDLTQSLLTIKHLL-----------
19 ..-------------------------------
20 ..DVVVQYVDLTSELQTLLYFMR----------