(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html
Citations (SAM, SAM-T99, HMMs)
- R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
- K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
- A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
Sequence numbers correspond to the following labels:
-
- T0187 TM1585, T. maritima
-
- gi|17987853|ref|NP_540487.1|_68:210 (NC_003317) PUTATIVE HYDROXYPYRUVATE REDUCTASE [Brucella melitensis]
- gi|17983583|gb|AAL52751.1| (AE009592) PUTATIVE HYDROXYPYRUVATE REDUCTASE [Brucella melitensis]
-
- gi|16265133|ref|NP_437925.1|_89:230 (NC_003078) putative hydroxypyruvate reductase protein [Sinorhizobium meliloti]
- gi|15141272|emb|CAC49785.1| (AL603646) putative hydroxypyruvate reductase protein [Sinorhizobium meliloti]
-
- gi|20894723|ref|XP_135143.1|_145:288 (XM_135143) similar to CG9886 gene product [Mus musculus]
-
- gi|13676533|dbj|BAB41180.1|_18:161 (AB060262) hypothetical protein [Macaca fascicularis]
-
- gi|21314996|gb|AAH30732.1|_18:161 (BC030732) Unknown (protein for MGC:37913) [Mus musculus]
-
- gi|18676755|dbj|BAB85018.1|_18:161 (AK074215) unnamed protein product [Homo sapiens]
-
- gi|15967047|ref|NP_387400.1|_120:262 (NC_003047) PUTATIVE HYDROXYPYRUVATE REDUCTASE PROTEIN [Sinorhizobium meliloti]
- gi|15076320|emb|CAC47873.1| (AL591793) PUTATIVE HYDROXYPYRUVATE REDUCTASE PROTEIN [Sinorhizobium meliloti]
-
- gi|17936943|ref|NP_533732.1|_92:237 (NC_003305) hydroxypyruvate reductase [Agrobacterium tumefaciens str. C58 (U. Washington)]
- gi|17741611|gb|AAL44048.1| (AE009253) hydroxypyruvate reductase [Agrobacterium tumefaciens str. C58 (U. Washington)]
-
- gi|15891700|ref|NP_357372.1|_95:240 (NC_003063) AGR_L_3166p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
- gi|15160156|gb|AAK90157.1| (AE008360) AGR_L_3166p [Agrobacterium tumefaciens str. C58 (Cereon)]
-
- gi|17549668|ref|NP_523008.1|_107:254 (NC_003296) PROBABLE HYDROXYPYRUVATE REDUCTASE OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]
- gi|17431922|emb|CAD18600.1| (AL646084) PROBABLE HYDROXYPYRUVATE REDUCTASE OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]
-
- gi|4033487sp|Q44472|TUD4_AGRVI_107:250 Putative hydroxypyruvate reductase
- gi|805293|gb|AAA68699.1| (U25634) putative hydroxypyruvate reductase; inducible by tartrate; Method: conceptual translation supplied by author [Rhizobium vitis]
- gi|1585264|prf||2124372D ttuD gene [Rhizobium vitis]
-
- gi|19388000|gb|AAH25834.1|_145:288 (BC025834) similar to hypothetical protein [Mus musculus]
- gi|19684145|gb|AAH25935.1| (BC025935) similar to hypothetical protein [Mus musculus]
- gi|21620001|gb|AAH33063.1| (BC033063) Unknown (protein for MGC:37851) [Mus musculus]
-
- gi|4033482sp|P70788|TUD3_AGRVI_54:197 Putative hydroxypyruvate reductase
- gi|984369|gb|AAB61624.1| (U32375) enzyme degrading primary tartrate degradation product [Rhizobium vitis]
-
- gi|14601127|ref|NP_147655.1|_48:198 (NC_000854) hypothetical protein [Aeropyrum pernix]
- gi|7516171|pir||D72697 hypothetical protein APE0996 - Aeropyrum pernix (strain K1)
- gi|5104665|dbj|BAA79980.1| (AP000060) 400aa long hypothetical protein [Aeropyrum pernix]
-
- gi|15596696|ref|NP_250190.1|_87:234 (NC_002516) conserved hypothetical protein [Pseudomonas aeruginosa]
- gi|11347789|pir||E83459 conserved hypothetical protein PA1499 [imported] - Pseudomonas aeruginosa (strain PAO1)
- gi|9947454|gb|AAG04888.1|AE004578_10 (AE004578) conserved hypothetical protein [Pseudomonas aeruginosa]
-
- gi|13541614|ref|NP_111302.1|_103:248 (NC_002689) Predicted glycerate kinase [Thermoplasma volcanium]
- gi|14325013|dbj|BAB59939.1| (AP000993) glycerate kinase [Thermoplasma volcanium]
-
- gi|1907334|gb|AAB66496.1|_103:248 (U87316) putative glycerate kinase [Methylobacterium extorquens]
-
- gi|16263221|ref|NP_436014.1|_87:230 (NC_003037) putative TtuD3 hydroxypyruvate reductase [Sinorhizobium meliloti]
- gi|14523892|gb|AAK65426.1| (AE007264) putative TtuD3 hydroxypyruvate reductase [Sinorhizobium meliloti]
-
- gi|14590403|ref|NP_142469.1|_99:248 (NC_000961) hypothetical protein [Pyrococcus horikoshii]
- gi|7518673|pir||B71162 hypothetical protein PH0495 - Pyrococcus horikoshii
- gi|3256900|dbj|BAA29583.1| (AP000002) 440aa long hypothetical protein [Pyrococcus horikoshii]
-
- gi|16119561|ref|NP_396267.1|_89:232 (NC_003064) AGR_pAT_bx66p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
- gi|17938918|ref|NP_535706.1| (NC_003306) hydroxypyruvate reductase [Agrobacterium tumefaciens str. C58 (Dupont)] [Agrobacterium tumefaciens str. C58 (U. Washington)]
- gi|15162117|gb|AAK90708.1| (AE007902) AGR_pAT_bx66p [Agrobacterium tumefaciens str. C58 (Cereon)]
- gi|17743779|gb|AAL46022.1| (AE008955) hydroxypyruvate reductase [Agrobacterium tumefaciens str. C58 (U. Washington)]
-
- gi|18976396|ref|NP_577753.1|_114:262 (NC_003413) putative glycerate kinase [Pyrococcus furiosus DSM 3638]
- gi|18891922|gb|AAL80148.1| (AE010128) putative glycerate kinase [Pyrococcus furiosus DSM 3638]
-
- gi|21542484sp|Q09235|YQ42_CAEEL_45:200 Hypothetical protein C13B9.2 in chromosome III
- gi|20198777|gb|AAA62515.2| (U21309) Hypothetical protein C13B9.2 [Caenorhabditis elegans]
-
- gi|14521745|ref|NP_127221.1|_94:241 (NC_000868) hypothetical protein [Pyrococcus abyssi]
- gi|7518011|pir||E75001 hypothetical protein PAB1021 - Pyrococcus abyssi (strain Orsay)
- gi|5458965|emb|CAB50451.1| (AJ248288) hypothetical protein [Pyrococcus abyssi]
-
- gi|18312544|ref|NP_559211.1|_108:254 (NC_003364) conserved hypothetical protein [Pyrobaculum aerophilum]
- gi|18160010|gb|AAL63393.1| (AE009815) conserved hypothetical protein [Pyrobaculum aerophilum]
-
- gi|15644333|ref|NP_229385.1|_91:237 (NC_000853) glycerate kinase, putative [Thermotoga maritima]
- gi|7462843|pir||A72236 hypothetical protein TM1585 - Thermotoga maritima (strain MSB8)
- gi|4982155|gb|AAD36652.1|AE001803_5 (AE001803) glycerate kinase, putative [Thermotoga maritima]
-
- gi|21315005|gb|AAH30736.1|_4:128 (BC030736) Unknown (protein for IMAGE:5132880) [Mus musculus]
-
- gi|17545205|ref|NP_518607.1|_93:240 (NC_003295) PUTATIVE HYDROXYPYRUVATE REDUCTASE OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]
- gi|17427496|emb|CAD14014.1| (AL646059) PUTATIVE HYDROXYPYRUVATE REDUCTASE OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]
-
- gi|13474290|ref|NP_105858.1|_88:231 (NC_002678) hypothetical protein [Mesorhizobium loti]
- gi|14025042|dbj|BAB51644.1| (AP003005) hypothetical protein [Mesorhizobium loti]
-
- gi|19920578|ref|NP_608684.1|_118:266 (NM_134840) CG9886 gene product [Drosophila melanogaster]
- gi|7295954|gb|AAF51252.1| (AE003583) CG9886 gene product [Drosophila melanogaster]
- gi|16769768|gb|AAL29103.1| (AY061555) LP09309p [Drosophila melanogaster]
-
- gi|15897575|ref|NP_342180.1|_86:221 (NC_002754) Glycerate kinase, putative [Sulfolobus solfataricus]
- gi|6015809|emb|CAB57636.1| (Y18930) hypothetical protein [Sulfolobus solfataricus]
- gi|13813834|gb|AAK40970.1| (AE006694) Glycerate kinase, putative [Sulfolobus solfataricus]
-
- gi|15807636|ref|NP_294881.1|_84:216 (NC_001263) hydroxypyruvate reductase, putative [Deinococcus radiodurans]
-
- gi|15922355|ref|NP_378024.1|_89:230 (NC_003106) 399aa long conserved hypothetical protein [Sulfolobus tokodaii]
- gi|15623144|dbj|BAB67133.1| (AP000988) 399aa long conserved hypothetical protein [Sulfolobus tokodaii]
-
- gi|21300335|gb|EAA12480.1|_167:320 (AAAB01008964) agCP11255 [Anopheles gambiae str. PEST]
-
- gi|10639623|emb|CAC11595.1|_80:222 (AL445064) glycerate kinase related protein [Thermoplasma acidophilum]
-
- gi|16082522|ref|NP_393931.1|_103:245 (NC_002578) Predicted glycerate kinase [Thermoplasma acidophilum]
-
- gi|21687104|ref|NP_660305.1|_118:222 (NM_145262) similar to CG9886 gene product [Homo sapiens]
- gi|18256912|gb|AAH21896.1|AAH21896 (BC021896) Unknown (protein for MGC:9528) [Homo sapiens]
-
- gi|22405563|gb|ZP_00000441.1|_101:215 (NZ_AAAA01000043) hypothetical protein [Ferroplasma acidarmanus]
-
- gi|17552152|ref|NP_498462.1|_98:166 (NM_066061) C13B9.2.p [Caenorhabditis elegans]
10 20 30 40 50 60
| | | | | |
1 PVPDENTIKTTRRVLELVDQLN.ENDTVLFLLSGGGSSLFELPLEGVSLEEIQKLTSALLKSGAS
2 PVPDGAGLAASRRLFNAVSGLS.EDDLVVALISGGGSALLPSPPEGMTLEDEIAVNKALLASGAP
3 PLPDEGGLKASKRLLAAVSGLT.GDDLVVALICGGGSALLPAPPPALSLEDEIAVNRALLASGAP
4 NLPDRDALRAALTIQQLAEGLT.ADDLLLVLISGGGSALLPAPIPPVTLEEKQMLTKLLAARGAT
5 NLPDRDALRAALAIRQLAEGLT.ADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTRLLAARGAT
6 NLPDRDALRAALTIQQLAEGLT.ADDLLLVLISGGGSALLPAPIPPVTLEEKQMLTKLLAARGAT
7 NLPDRDALRAALAIQQLAEGLT.ADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTRLLAARGAT
8 PVPDEAGLAASAALLETVGGLT.ADDLVVALISGGGSALLPAPPGGLTLEDEIAVNKALLASGAP
9 PVPDDKSAEAAKRILAAVEGLT.ADDMVIALISGGGSALMVAPAEGMTLADKMAVNRALLASGAT
10 PVPDDKSAEAAKRILAAVEGLT.ADDMVIALISGGGSALMVAPAEGMTLADKMAVNRALLASGAT
11 PVPDAAGLQATARMRRLVSGLT.EDDLVIALISGGGSSLLVAPGEGLTLADKQAVNAALLQCGAT
12 PVPDEMSIKAAEKIFAAVQGLG.PDDLVVALISGGGSSLLVSPTGKMTLTDKRAVNQALLASGAT
13 NLPDRDALRAALTIQQLAEGLT.ADDLLLVLISGGGSALLPAPIPPVTLEEKQMLTKLLAARGAT
14 PVPDDMSVEAAVRIIGAVRDLG.PDDLVIALISGGGSSLLVSPAAGMTLADKKAVNKALLASGAT
15 PLPDEWSLRAGRRLLEWAGSAG.EGDNVVVLVSGGGSALAEVPMEGLALEDLREVNMLLLKSGAS
16 PVPDDAGERVARRVLELISGLN.ESDRVIFLLSGGGSALLSLPAEGIGLADKQAVNKALLKSGAA
17 PLTSTLSVTSSKKLLSKARP-S.ANDLVLVLISGGGSSLFEIPQEGITIDQMASISRAMMDHSAN
18 PVPDAAGIEATKEALALAASAG.PEDEVLVLLSGGGSANWIAPAGNLTLAEKQAITKALLRSGAP
19 PVPDCNGLIASHALFEAVRGLT.PDDLVVALFCGGGSALLPCPPEELALEDEIALNRALLASGAP
20 PIPDEKSILGAKEALSILNRAR.ENDIVFILISGGGSALFELPEEGISLEDLKLTTDLLLKSGAK
21 PVPDRAGFVASRRLLDAVSDLT.EDDLVVALISGGGSSLLALPCEGLTLDDEIAVAKMLLSSGAP
22 PIPDENSVKGAKLGVELAKKVK.ENDILLVLISGGGSALFTLPEDGISLEDKIKTNELLLKSGAK
23 NLPDEKSVFATRKVISEIRDFDsESTIFLFLISGGGSALLTSPSAPLDLAEKLETIRIMQAHGAT
24 PIPDENSIRGAIEGLKLLEKVK.EEDIVFVLISGGGSALFELPEDGISLEDLKLTNELLLKSGAK
25 PVPGADTLVASRRLLEYLEGVG.ENDVVFVVISGGGSALFEVPVEGMELGDIARISAELMRRGAD
26 PVPDENTIKTTRRVLELVDQLN.ENDTVLFLLSGGGSSLFELPLEGVSLEEIQKLTSALLKSGAS
27 -------------------GLT.ADDLLLVLISGGGSALLPAPIPPVTLEEKQMLTKLLAARGAT
28 PVPDEAGEQAAQAIFDRVSALT.EHDRLIVLVSGGGSSLLSLPAEGVPMADLKAVTRELLRCGAP
29 PVPDAAGLEASRRLLAKVQGLT.EDDLVVALISGGGSALLPSPAAGLTLADEIAVNEALLASGAP
30 NLPDENALKAAREIKQLAEKMT.AQDILFVFISGGGSALLPLPRSPLTLEDKRSIADKLMKRGAS
31 PLPDENSIKAGKRMIELLAN-E.DYDLVIFAISGGASALVEY--SEIPLDELKIINKVLVTSGLG
32 PVPDERSXAAAEEALRQLGALR.PDQEALILVSGGGSALLAAP-DGVTLAEKQALTRELLRAGAD
33 PDISELSFKAGTEVIKFLKN-E.DYDLLIFLLSGGASALMEY--SNVPYEILRDINEKLVKSGLS
34 NLPDEGSLMAAKKIKQIAHSMT.SDDVLCVLVSGGGSALLCLPKEPITLEEKLQLIKSLATAGAS
35 PYTSSLSVSSSRTLLSKVKP-G.PNDAVIVLISGGGSSLFEIPEEGITIDQISEISKKMMQASAD
36 PYTSSLSVSSSRTLLSKVKP-G.PNDAVIVLISGGGSSLFEIPEEGITIDQISEISKKMMQASAD
37 ----------------------.-----------------AAPIPPVTLEEKQTLTRLLAARGAT
38 PYVSSLSVESSKKLLSHLDRLN.QNDLVIVLISGGGSSLFEILETGIDVNDLKDISAEIMENDGD
39 ----------------------.------------------------------------------
70 80 90 100 110 120
| | | | | |
1 IEEINTVRKHLSQVKGGRFAERVFPA.K.VVALVLSDVLGDRLDVIASGPAWP.....DSS..TS
2 ISAMNAVRKHLSTIKGGRLAAAAHPA.K.VFSLVVSDIPGDNPAFVASGPTVP.....DET..SR
3 ISAMNAVRKHVSLIKGGRLAAAAHPA.R.VVSLVVSDIPGDDAAMVASGPTIA.....DAA..SR
4 IQELNTIRKALSQLKGGGLAQAAYPA.Q.VISLILSDVIGDPLEVIASGPTVA.....STH..SV
5 IQELNTIRKALSQLKGGGLAQAAYPA.Q.VVSLILSDVVGDPVEVIASGPTVA.....SSH..SV
6 IQELNTIRKALSQLKGGGLAQAAYPA.Q.VISLILSDVIGDPLEVIASGPTVA.....SAH..SV
7 IQELNTIRKALSQLKGGGLAQAAYPA.Q.VVSLILSDVEGDPVEVIASGPTVA.....SSH..NV
8 ISAMNVVRKHVSRIKGGRLALAAAPA.R.VVSLVVSDVPGDNPAFVASGPTVA.....DRS..SL
9 ISEMNAVRKHLSRIKGGRLALAAKPA.K.VVSLLISDVPGDDPSEIASGPTVA.....DPS..DI
10 ISEMNAVRKHLSRIKGGRLALAAKPA.K.VVSLLISDVPGDDPSEIASGPTVA.....DPS..DI
11 IAEMNCVRRHLSAVKGGRLAAACHPA.R.VVTLMISDVPGDHPIDIASGPTVA.....DPT..TR
12 ISEMNTVRKHLSAIKGGHLARAALPA.K.LVTLIISDVPGDDPSEIASGPTVA.....DPT..TL
13 IQELNTIRKALSQLKGGGLAQAAYPA.Q.VISLILSDVIGDPLEVIASGPTVA.....SAH..SV
14 ISEMNAVRKQLSGIKGGRLAQLAHPA.R.VVTLVISDVPGDDPSEIASGPTVA.....NDT..TI
15 IHEINTVRKHLSRIKGGRLAATAYPA.R.VLGVYASDVPGDRLDMIASGPTVP.....DPT..TY
16 IGEMNCVRKHLSAIKGGRLAKACWPA.S.VYTYAISDVPGDEATVIASGPSVG.....DPT..TS
17 IYELNTIRSALSSVKGGKLARILYPA.T.IIALIISDVPGDDISIIASGPLAE.....NKL..--
18 INEINAVRKHLSRIKGGRLAMAARNA.KsILTLAISDVPHDDPSVIASGPTVP.....DPS..TL
19 ISVMNAIRKQVSRIKGGRLAAACHPA.K.VISFIVSDVPGDDPAQVASGPTVP.....DAT..DR
20 IHEINTVRKHISKVKGGKLAKMIKGT.G.IV-LIISDVVGDNLEAIASGPTVK.....DPT..TF
21 ISAMNTVRTQLSRIKGGRLAIAAYPA.K.VVTLIVSDIPGDDPVLVASGPTVL.....SRS..TP
22 IYEINTVRKHISKVKGGKLAKLV-KG.T.LISLIVSDVVGDPLEAIASGPTVK.....DPT..TF
23 IQELNTIRQNLSDVKGGKLLREIKKG.C.SIALIISDVIGNPVELIASGPTVIpahqqDKF..II
24 IHEINTVRKHISKVKGGKLAKKIKGT.G.IV-LIISDVVGDNLEAIASGPTVK.....DPT..TF
25 IVELNAVRKRLSRVKGGKLLRLVKAS.A.VISLIISDVVGDRLDTIASGPTAP.....DGT..SR
26 IEEINTVRKHLSQVKGGRFAERVFPA.K.VVALVLSDVLGDRLDVIASGPAWP.....DSS..TS
27 IQELNTIRKALSQLKGGGLAQAAYPA.Q.VISLILSDVIGDPLEVIASGPTVA.....SAH..SV
28 ITDMNIVRKHLSRIQGGRLAAA-SRA.P.VTTLIVSDVAGDDPSAIASGPTVP.....DPS..TY
29 IAAMNTIRKHVSTIKGGRLAAAAWPA.K.VVSLVVSDIPGDNPALVASGPTVP.....DTG..SR
30 IQEINAVRIACSDIKGGRLARLAGQA.GlLVTFVLSDIIGDPLELIACGPTIQ.....PEA..-A
31 INKINIVRKHLSKVKGGKILEYVKDKiP.IVSFIVSDVPGNDISSIGSGLTSI.....DNS..SN
32 IGEINTVRRHLSRVKGGRLAQA-TPA.R.VRALLLSDVVGDDPSVIASGPTVP.....DPT..TF
33 VNEINIVRKHLSLIKGGKLTEF-SKA.P.ILTLIVSDVPGGDLSAVGSGPTLP.....DSS..TV
34 IDELNNVRIALSEVKGGQLALAAEHAyR.VYSYVISDIVGDPVALIASGPTVI.....QKGvaVN
35 IYELNTIRSCLSSVKGGKLAKLLYPA.S.VFAYIISDVPGDDVSIIASGPLSE.....NKL..--
36 IYELNTIRSCLSSVKGGKLAKLLYPA.S.VFAYIISDVPGDDVSIIASGPLSE.....NKL..--
37 IQELNTIRKALSQLKGGGLAQAAYPA.Q.VVSLILSDVVGDPVEVIASGPTVA.....SSH..NV
38 IYVLNRLRSSLSAVKNGKLAKYLYPA.S.VAGYIISDVVYDNLNIIASGPLVN.....---..--
39 ----------------------MTKG.C.SIALIISDVIGNPVELIASGPTVIpahqqDKF..II
130 140 150
| | |
1 EDALKVLEKYGIE..TSESVKRAILQETPKHL
2 DEALKIIERYRLD..LPQAALAHIK-------
3 EDALKIVERYRLA..LPEKVMRWL--------
4 QDCLHILNHYGLRaaLPRSVKTVL--------
5 QDCLHILNRYGLRaaLPRSVKTVL--------
6 QDCLHILNHYGLRaaLPRSVKTVL--------
7 QDCLHILNRYGLRaaLPRSVKTVL--------
8 EEAREIVARYAIA..LPERVTAHLA-------
9 ATVREIVARYGLD..LPETVRKVLEKGE----
10 ATVREIVARYGLD..LPETVRKVLEKGE----
11 DDALAVLARYRVA..VPASVLAHLRGDAAE--
12 ADAAAIIARYGID..LPESARAVLVQ------
13 QDCLHILNHYGLRaaLPRSVKTVL--------
14 DDAREIVSRYRLV..LPPAAQDVLAN------
15 GDALAVLERYGLRdsAPPRVVALLEAGARGE-
16 ADALAILKRYAID..VPQNVLDWLADPRSE--
17 -DPSAVYAKYRDI..IPIDITKYVENSSIEDL
18 ADARAICERRGIS..LPESALALLNDP-----
19 AAARAMRDAWRIE..LPERLVDWLKG------
20 EDAKRILELYDIWekVPESVRLHIERGLRGE-
21 QDALRVIDRYGMA..LPDHVIRHLQD------
22 RDAYRILKLYNLWdkIPESVRRYIELGLEG--
23 SNILESLKINKLE..LPVNVKNVLENHEKEQL
24 QDAKRILELYGIWdrVPESVRSHIEKGIR---
25 EFAIRVLKKYGIWgeLPPRIRAVFEGG-----
26 EDALKVLEKYGIE..TSESVKRAILQETP---
27 QDCLHILNHYGLRaaLPRSVKTVL--------
28 ADALAILARWGAQ..APESVRAHLERGARGE-
29 EDALASISAYGMK..LPASVMAHINS------
30 ASPSDILKKHHVWeeLSPEIRRVFEQPEE---
31 DDALEILKAIGLE..KYSKY------------
32 ADALAVLEKYSIA..AP---------------
33 DDAKLILNKVGLG..EYSKYLIETKKEV----
34 GKAKEILEKYGLWskLPDSILKVIEQPTVRE-
35 -DPVAVYERFRNV..IGVDIERFLKTAQI---
36 -DPVAVYERFRNV..IGVDIERFLKTAQI---
37 QDCLHILNRYGLRaaLPRSVKTVL--------
38 -------------..-----------------
39 SNILESLKINKLE..LPVNVKNVLENHEKEQL