Sequence numbers correspond to the following labels:

1. • T0187 TM1585, T. maritima
2. • gi|15644333|ref|NP_229385.1|_301:416 (NC_000853) glycerate kinase, putative [Thermotoga maritima]
   • gi|7462843|pir||A72236 hypothetical protein TM1585 - Thermotoga maritima (strain MSB8)
   • gi|4982155|gb|AAD36652.1|AE001803_5 (AE001803) glycerate kinase, putative [Thermotoga maritima]
3. • gi|16119561|ref|NP_396267.1|_305:420 (NC_003064) AGR_pAT_bx66p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
   • gi|17938918|ref|NP_535706.1| (NC_003306) hydroxypyruvate reductase [Agrobacterium tumefaciens str. C58 (Dupont)] [Agrobacterium tumefaciens str. C58 (U. Washington)]
   • gi|15162117|gb|AAK90708.1| (AE007902) AGR_pAT_bx66p [Agrobacterium tumefaciens str. C58 (Cereon)]
   • gi|17743779|gb|AAL46022.1| (AE008955) hydroxypyruvate reductase [Agrobacterium tumefaciens str. C58 (U. Washington)]
4. • gi|17549668|ref|NP_523008.1|_324:439 (NC_003296) PROBABLE HYDROXYPYRUVATE REDUCTASE OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]
   • gi|17431922|emb|CAD18600.1| (AL646084) PROBABLE HYDROXYPYRUVATE REDUCTASE OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]
5. • gi|17936943|ref|NP_533732.1|_305:422 (NC_003305) hydroxypyruvate reductase [Agrobacterium tumefaciens str. C58 (U. Washington)]
   • gi|17741611|gb|AAL44048.1| (AE009253) hydroxypyruvate reductase [Agrobacterium tumefaciens str. C58 (U. Washington)]
6. • gi|15891700|ref|NP_357372.1|_308:425 (NC_003063) AGR_L_3166p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
   • gi|15160156|gb|AAK90157.1| (AE008360) AGR_L_3166p [Agrobacterium tumefaciens str. C58 (Cereon)]
7. • gi|15596696|ref|NP_250190.1|_305:419 (NC_002516) conserved hypothetical protein [Pseudomonas aeruginosa]
   • gi|11347789|pir||E83459 conserved hypothetical protein PA1499 [imported] - Pseudomonas aeruginosa (strain PAO1)
   • gi|9947454|gb|AAG04888.1|AE004578_10 (AE004578) conserved hypothetical protein [Pseudomonas aeruginosa]
8. • gi|13474290|ref|NP_105858.1|_305:420 (NC_002678) hypothetical protein [Mesorhizobium loti]
   • gi|14025042|dbj|BAB51644.1| (AP003005) hypothetical protein [Mesorhizobium loti]
9. • gi|16265133|ref|NP_437925.1|_306:421 (NC_003078) putative hydroxypyruvate reductase protein [Sinorhizobium meliloti]
   • gi|15141272|emb|CAC49785.1| (AL603646) putative hydroxypyruvate reductase protein [Sinorhizobium meliloti]
10. • gi|17987853|ref|NP_540487.1|_285:401 (NC_003317) PUTATIVE HYDROXYPYRUVATE REDUCTASE [Brucella melitensis]
    • gi|17983583|gb|AAL52751.1| (AE009592) PUTATIVE HYDROXYPYRUVATE REDUCTASE [Brucella melitensis]
11. • gi|21314996|gb|AAH30732.1|_272:393 (BC030732) Unknown (protein for MGC:37913) [Mus musculus]
12. • gi|15967047|ref|NP_387400.1|_337:454 (NC_003047) PUTATIVE HYDROXYPYRUVATE REDUCTASE PROTEIN [Sinorhizobium meliloti]
    • gi|15076320|emb|CAC47873.1| (AL591793) PUTATIVE HYDROXYPYRUVATE REDUCTASE PROTEIN [Sinorhizobium meliloti]
13. • gi|4033482sp|P70788|TUD3_AGRVI_267:384 Putative hydroxypyruvate reductase
    • gi|984369|gb|AAB61624.1| (U32375) enzyme degrading primary tartrate degradation product [Rhizobium vitis]
14. • gi|21315005|gb|AAH30736.1|_239:360 (BC030736) Unknown (protein for IMAGE:5132880) [Mus musculus]
15. • gi|21687104|ref|NP_660305.1|_333:454 (NM_145262) similar to CG9886 gene product [Homo sapiens]
    • gi|18256912|gb|AAH21896.1|AAH21896 (BC021896) Unknown (protein for MGC:9528) [Homo sapiens]
16. • gi|13676533|dbj|BAB41180.1|_272:393 (AB060262) hypothetical protein [Macaca fascicularis]
17. • gi|18976396|ref|NP_577753.1|_333:449 (NC_003413) putative glycerate kinase [Pyrococcus furiosus DSM 3638]
    • gi|18891922|gb|AAL80148.1| (AE010128) putative glycerate kinase [Pyrococcus furiosus DSM 3638]
18. • gi|16263221|ref|NP_436014.1|_304:418 (NC_003037) putative TtuD3 hydroxypyruvate reductase [Sinorhizobium meliloti]
    • gi|14523892|gb|AAK65426.1| (AE007264) putative TtuD3 hydroxypyruvate reductase [Sinorhizobium meliloti]
19. • gi|14521745|ref|NP_127221.1|_313:428 (NC_000868) hypothetical protein [Pyrococcus abyssi]
    • gi|7518011|pir||E75001 hypothetical protein PAB1021 - Pyrococcus abyssi (strain Orsay)
    • gi|5458965|emb|CAB50451.1| (AJ248288) hypothetical protein [Pyrococcus abyssi]
20. • gi|14590403|ref|NP_142469.1|_318:433 (NC_000961) hypothetical protein [Pyrococcus horikoshii]
    • gi|7518673|pir||B71162 hypothetical protein PH0495 - Pyrococcus horikoshii
    • gi|3256900|dbj|BAA29583.1| (AP000002) 440aa long hypothetical protein [Pyrococcus horikoshii]
21. • gi|4033487sp|Q44472|TUD4_AGRVI_321:437 Putative hydroxypyruvate reductase
    • gi|805293|gb|AAA68699.1| (U25634) putative hydroxypyruvate reductase; inducible by tartrate; Method: conceptual translation supplied by author [Rhizobium vitis]
    • gi|1585264|prf||2124372D ttuD gene [Rhizobium vitis]
22. • gi|18312544|ref|NP_559211.1|_327:441 (NC_003364) conserved hypothetical protein [Pyrobaculum aerophilum]
    • gi|18160010|gb|AAL63393.1| (AE009815) conserved hypothetical protein [Pyrobaculum aerophilum]
23. • gi|17545205|ref|NP_518607.1|_314:432 (NC_003295) PUTATIVE HYDROXYPYRUVATE REDUCTASE OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]
    • gi|17427496|emb|CAD14014.1| (AL646059) PUTATIVE HYDROXYPYRUVATE REDUCTASE OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]
24. • gi|14601127|ref|NP_147655.1|_271:389 (NC_000854) hypothetical protein [Aeropyrum pernix]
    • gi|7516171|pir||D72697 hypothetical protein APE0996 - Aeropyrum pernix (strain K1)
    • gi|5104665|dbj|BAA79980.1| (AP000060) 400aa long hypothetical protein [Aeropyrum pernix]
25. • gi|16082522|ref|NP_393931.1|_306:417 (NC_002578) Predicted glycerate kinase [Thermoplasma acidophilum]
26. • gi|10639623|emb|CAC11595.1|_283:394 (AL445064) glycerate kinase related protein [Thermoplasma acidophilum]
27. • gi|20894723|ref|XP_135143.1|_399:520 (XM_135143) similar to CG9886 gene product [Mus musculus]
28. • gi|19388000|gb|AAH25834.1|_399:520 (BC025834) similar to hypothetical protein [Mus musculus]
    • gi|19684145|gb|AAH25935.1| (BC025935) similar to hypothetical protein [Mus musculus]
    • gi|21620001|gb|AAH33063.1| (BC033063) Unknown (protein for MGC:37851) [Mus musculus]
29. • gi|1907334|gb|AAB66496.1|_319:436 (U87316) putative glycerate kinase [Methylobacterium extorquens]
30. • gi|21542484sp|Q09235|YQ42_CAEEL_275:394 Hypothetical protein C13B9.2 in chromosome III
    • gi|20198777|gb|AAA62515.2| (U21309) Hypothetical protein C13B9.2 [Caenorhabditis elegans]
31. • gi|17552152|ref|NP_498462.1|_241:360 (NM_066061) C13B9.2.p [Caenorhabditis elegans]
32. • gi|15897575|ref|NP_342180.1|_287:397 (NC_002754) Glycerate kinase, putative [Sulfolobus solfataricus]
    • gi|6015809|emb|CAB57636.1| (Y18930) hypothetical protein [Sulfolobus solfataricus]
    • gi|13813834|gb|AAK40970.1| (AE006694) Glycerate kinase, putative [Sulfolobus solfataricus]
33. • gi|19920578|ref|NP_608684.1|_364:486 (NM_134840) CG9886 gene product [Drosophila melanogaster]
    • gi|7295954|gb|AAF51252.1| (AE003583) CG9886 gene product [Drosophila melanogaster]
    • gi|16769768|gb|AAL29103.1| (AY061555) LP09309p [Drosophila melanogaster]
34. • gi|22405563|gb|ZP_00000441.1|_309:413 (NZ_AAAA01000043) hypothetical protein [Ferroplasma acidarmanus]
35. • gi|15922355|ref|NP_378024.1|_286:397 (NC_003106) 399aa long conserved hypothetical protein [Sulfolobus tokodaii]
    • gi|15623144|dbj|BAB67133.1| (AP000988) 399aa long conserved hypothetical protein [Sulfolobus tokodaii]
36. • gi|13541614|ref|NP_111302.1|_306:416 (NC_002689) Predicted glycerate kinase [Thermoplasma volcanium]
    • gi|14325013|dbj|BAB59939.1| (AP000993) glycerate kinase [Thermoplasma volcanium]
37. • gi|21300335|gb|EAA12480.1|_421:542 (AAAB01008964) agCP11255 [Anopheles gambiae str. PEST]

              10        20           30        40            50        
              |         |            |         |             |        
   1 LKKPAALIFGGETVVHVKGN...GIGGRNQELALSAAIALEGIE....GVILCSAGTDGTDGP..
   2 LKKPAALIFGGETVVHVKGN...GIGGRNQELALSAAIALEGIE....GVILCSAGTDGTDGP..
   3 FRKPVVILSGGETTVTLRGK...GKGGRNTEFLLSLAIEIAEHG....DITALAADTDGIDGS..
   4 FAAPCVLLSGGETTVTLRGN...GRGGRNVEFLLSLAVALDGLP....GVHAIAGDTDGVDGV..
   5 VKGPAVLLSGGETTVTIGKGpa.GKGGRNTEFLLSLALTLKGAD....GIWAIAGDSDGIDGV..
   6 VKGPAVLLSGGETTVTIGKGpa.GKGGRNTEFLLSLALTLKGAD....GIWAIAGDSDGIDGV..
   7 --APCVILSGGETTVTVRGN...GRGGRNAEFLLSLTAELKGEP....NIWALAGDTDGIDGS..
   8 FSKPVLILSGGETTVTLRAK...GKGGRNSEFLLAFAIGISGVQ....GIHALAADTDGIDGS..
   9 FPKPALLLSGGETTVTVRGE...GRGGRNSEFLLSLALGIDGIG....GISALAADTDGIDGS..
  10 FKKPVVILSGGETTVTIGSPg..GKGGRNSEFLLSFALDIDGYA....NIHALAADTDGIDGS..
  11 -KGPVCLLAGGEPTVQLQGS...GKGGRNQELALHVGVELGRQPlgpiDVLFLSGGTDGQDGP..
  12 FSKPVVLLSGGETTVTISGEry.GKGGRNSEFLLSLALDIDGIG....GIDALAADTDGIDGS..
  13 VRGPAVLLSGGETSVSLPADtk.GRGGRNSEFLLSLAIGLDGAK....GIWALSGDTDGIDGI..
  14 -KGPVCLLAGGEPTVQLQGS...GKGGRNQELALHVGVELGRQPlgpiDVLFLSGGTDGQDGP..
  15 -RGPVCLLAGGEPTVQLQGS...GRGGRNQELALRVGAELRRWPlgpiDVLFLSGGTDGQDGP..
  16 -RGPVCLLAGGEPTVQLQGS...GRGGRNQELALRVGAELRRWPlgqiDVLFLSGGTDGQDGP..
  17 FKRPCVLIAGGETTVTIQGEa..GLGGPNQELALSIARKIAGLR....GVAVLVIDTDGTDGP..
  18 FERPVVLLSGGETTVTLRGH...GRGGRNTEFLLSLAIAAEGLS....-FASLAADTDGIDGS..
  19 FEPPVVLVFGGETTVTIEGEg..GKGGPNQELALSATRKIKGLN....-AILVAFDTDGTDGP..
  20 FEPPVVLVFGGETTVTIEGKg..GKGGPNQEIALSATRKISDLE....-ALIVAFDTDGTDGP..
  21 -AAPAVILSGGESTVSLGAMte.GRGGRNTEFLLSLAVALKGAS....GIWAIAGDTDGIDGV..
  22 -RPPLALLAGGETVVTVRGG...GRGGRNQELCLSFSIAVRGLR....NISAACLGTDGVDGN..
  23 -AAPVALVSGGECTVTLPPGltgGRGGRCAEFLLSLGIALEDMG....DVYALAADTDGIDGS..
  24 VKPPAALLAGGETTVTVRGG...GRGGRNMELALAWSLAMAYWSpea.PAAILAMDTDGIDGR..
  25 -GRSFWIVMGGETTVNVRGN...GIGGRNLELSLLFMKKC-NFS....DFLFISMGTDGIDGV..
  26 -GRSFWIVMGGETTVNVRGN...GIGGRNLELSLLFMKKC-NFS....DFLFISMGTDGIDGV..
  27 -KGPVCLLAGGEPTVQLQGS...GKGGRNQELALHVGVELGRQPlgpiDVLFLSGGTDGQDGP..
  28 -KGPVCLLAGGEPTVQLQGS...GKGGRNQELALHVGVELGRQPlgpiDVLFLSGGTDGQDGP..
  29 --RRVALISGGELTVTIRGE...GDGGPNQEYALALAIALDGAE....GIAGIAADTDGTDGGrg
  30 -NYPIALLFGGETTVHLSENp..GKGGRNQEMVLSCLDALKTRVpah.NFTFLSAGTDGQDGP..
  31 -NYPIALLFGGETTVHLSENp..GKGGRNQEMVLSCLDALKTRVpah.NFTFLSAGTDGQDGP..
  32 FRRPYYLLVGGEPEVTIQGKa..GKGGRNGEVCLSFLKYAKKRN....RFELLGFATDGIDGN..
  33 -KKPLFLICGGEPVIKVSGH...GLGGRSQHLALLMSQALHRDEamr.DCTFLSAGTDGIDGP..
  34 -GEPFWFVCGGETTVTVTGN...GSGGRNQELAVRIMEDISN-N....DFLFISMGTDGIDGK..
  35 LKPPYTLLAGGEPDVKIEGKa..GKGGRNGEVCLGFLKWVKRNSnh..RFKLYAIATDGIDGN..
  36 -GKSFWFVAGGETTVNVKGN...GIGGRNLELALRFM-KLANFS....DFLFLSIGTDGIDGV..
  37 KEKPLLIVGAGEPTVCVSGG...GKGGRNQELALRFTVGVRELErvpdSVYFLSAGTDGIDGP..


          60        70            80        90          100       110  
          |         |             |         |            |         |  
   1 ..TDAAGGIVDGSTAKTL..K..AMGEDPYQYLKNNDSYNALKKSG...ALLITGPTGTNVNDLI
   2 ..TDAAGGIVDGSTAKTL..K..AMGEDPYQYLKNNDSYNALKKSG...ALLITGPTGTNVNDLI
   3 ..EDNAGSFVDGGSVARL..C..AAGLDPYDLLVSNDAWTGFNSTK...DLFVTGPTGTNVNDFR
   4 ..EEIAGACIAPDTIARA..R..ALGLHPRACLDNNDGHGFFQALG...DAVITGPTLTNVNDFR
   5 ..EDAAGAVVTPDTLDRI..R..AAGVDPRQSLVSHDSYTAFKAAG...DLVVTGPTLTNVNDIR
   6 ..EDAAGAVVTPDTLDRI..R..AAGVDPRQSLVSHDSYTAFKAAG...DLVVTGPTLTNVNDIR
   7 ..EDNAGALMTPCSHARG..E..KAGLKIRDELYDNNGYGYFQALG...DLLVTGPTRTNVNDFR
   8 ..ENNAGAFADASTVSRM..R..AAGVDAKAMLAGNNAWTAFNAVG...DLFVPGPTGTNVNDLR
   9 ..EDNAGAFADHTTIARL..L..ARRLDAAALLHKNDSWAAFDALG...DLFKPGPTGTNVNDFR
  10 ..EDNAGAFADGGTVSRL..Q..KLGEDGMARLNANDAWTAFDALG...DLFVPGPTGTNVNDLR
  11 ..TKVAGAWVMSDLISQA..S..AESLDIATSLTNNDSYTFFCRFRggtHLLHTGLTGTNVMDVH
  12 ..EDNAGAFADGASIGRM..R..AAGADPRSHLAGHDAWTAFAASG...DLFVPGPTGTNVNDLR
  13 ..EDAAGAMIGPDSLARM..R..GSGIDPRSALSRHDSYTAFKAID...DLVITGPTLTNVNDIR
  14 ..TKVAGAWVMSDLISQA..S..AESLDIATSLTNNDSYTFFCRFRggtHLLHTGLTGTNVMDVH
  15 ..TEAAGAWVTPELASQA..A..AEGLDIATFLAHNDSHTFFCCLQggaHLLHTGMTGTNVMDTH
  16 ..TEAAGAWVTPELASQA..A..AEGLDMATFLAHNDSHTFFCRLQggaHLLHTGMTGTNVMDTH
  17 ..TDAAGGLVDSYTLEVL..K..KENIDVEEYLKRHNAYEALKRAK...ALVITGPTRTNVNSMM
  18 ..ESNAGAFADGSSATRL..R..ALGRDPVALLSGNDAWTAFNCLE...DLFVPGPTGTNVNDFR
  19 ..TDAAGGIVDGETYEKL..R..RKGIDIEKVLKEHNSYEALKKVG...SLLFTGPTGTNVNSMI
  20 ..TDAAGGIVDGTTYKKL..R..EKGIDVEKVLKEHNSYEALKKVG...GLLFTGPTGTNVNSIV
  21 ..EDAAGALVAPDSLIRM..R..DAGIDPRATLSAHDSYTAFKAIG...DLVVTGPTLTNVNDIR
  22 ..SPAAGAVVDGGVAEEA..E..AMGLDPFEYLNNNDSYTFFEKLG...RAVITGYTGTNVNDVF
  23 ..EGNAGAVLDPQSIGRA..A..ARGVAARAALDAHDAYGFFAAAG...DLIVTGPTRTNVNDYR
  24 ..SDAAGAVAWPWLPVAL..R..DAGLDPYQLLADNDSERAFAYAG...SLVSTGLTGTNLNSVV
  25 ..SPAAGGIVDAST--KA..R..ISSEEIDQALKNNDSYTLLSKYG...SAIMTGRTGNNVSDIV
  26 ..SPAAGGIVDAST--KA..R..ISSEEIDQALKNNDSYTLLSKYG...SAIMTGRTGNNVSDIV
  27 ..TKVAGAWVMSDLISQA..S..AESLDIATSLANNDSYTFFCRFRggtHLLHTGLTGTNVMDVH
  28 ..TKVAGAWVMSDLISQA..S..AESLDIATSLTNNDSYTFFCRFRggtHLLHTGLTGTNVMDVH
  29 aaTDPAGGLVDATTLSRA..Q..AAGLDPKAMLLDNDSTRFFATIG...DLVQPGPTRTNVNDCR
  30 ..TDAAGAIISNEDLPL-..-..NSLLNSSEFLQNSDSYNFWRQFKggaNHILTGPSGTNVMDIQ
  31 ..TDAAGAIISNEDLPL-..-..NSLLNSSEFLQNSDSYNFWRQFKggaNHILTGPSGTNVMDIQ
  32 ..SEYAGCKVSSDM----..E..IREDEINNALETHNSYGLLESHK...AVIKTGYTHTNVNNIY
  33 ..TDAAGAFGDSSVVESYlgD..HTLDELAETLRNCDSYNFYKNLAqgeHHVLTGHTGTNVMDLH
  34 ..SIAAGGIVDNSTRID-..-..----NLEEYLANNDTYTALSKAH...GAIITGRTGNNVSDIM
  35 ..SEYAGCIVDENTIVD-..-..----NIEYYIYSHSSYEALEKVG...RVIKTGYTFTNVNNVY
  36 ..SPAAGGIVSSDM--KL..K..ISSQELEETLDRNDAFTLLSAYH...GAIMTGRTGNNVSDIM
  37 ..TEVAGAIGGAFVARAF..EetFHLAEAKTFLERNDSYRFYEAVSggqYFVKTGHTGTNVMDVH


           
          
   1 IGLIV
   2 IGLI-
   3 AILI-
   4 AIVI-
   5 AILI-
   6 AILI-
   7 AILIL
   8 AILI-
   9 AVLI-
  10 AILI-
  11 LLIL-
  12 AILI-
  13 AILI-
  14 LLIL-
  15 LLFL-
  16 LLFL-
  17 IAVI-
  18 AILV-
  19 IAII-
  20 IAIV-
  21 AILI-
  22 IALV-
  23 VILIL
  24 VVLL-
  25 VAYV-
  26 VAYV-
  27 LLIL-
  28 LLIL-
  29 VILV-
  30 ILLL-
  31 ILLL-
  32 VL---
  33 FLVV-
  34 L----
  35 VLE--
  36 VGY--
  37 L----