(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html
Citations (SAM, SAM-T99, HMMs)
- R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
- K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
- A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
Sequence numbers correspond to the following labels:
-
- T0187 TM1585, T. maritima
-
- gi|16265133|ref|NP_437925.1|_4:147 (NC_003078) putative hydroxypyruvate reductase protein [Sinorhizobium meliloti]
- gi|15141272|emb|CAC49785.1| (AL603646) putative hydroxypyruvate reductase protein [Sinorhizobium meliloti]
-
- gi|17936943|ref|NP_533732.1|_4:150 (NC_003305) hydroxypyruvate reductase [Agrobacterium tumefaciens str. C58 (U. Washington)]
- gi|17741611|gb|AAL44048.1| (AE009253) hydroxypyruvate reductase [Agrobacterium tumefaciens str. C58 (U. Washington)]
-
- gi|15891700|ref|NP_357372.1|_7:153 (NC_003063) AGR_L_3166p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
- gi|15160156|gb|AAK90157.1| (AE008360) AGR_L_3166p [Agrobacterium tumefaciens str. C58 (Cereon)]
-
- gi|13474290|ref|NP_105858.1|_4:146 (NC_002678) hypothetical protein [Mesorhizobium loti]
- gi|14025042|dbj|BAB51644.1| (AP003005) hypothetical protein [Mesorhizobium loti]
-
- gi|17549668|ref|NP_523008.1|_21:166 (NC_003296) PROBABLE HYDROXYPYRUVATE REDUCTASE OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]
- gi|17431922|emb|CAD18600.1| (AL646084) PROBABLE HYDROXYPYRUVATE REDUCTASE OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]
-
- gi|16263221|ref|NP_436014.1|_4:145 (NC_003037) putative TtuD3 hydroxypyruvate reductase [Sinorhizobium meliloti]
- gi|14523892|gb|AAK65426.1| (AE007264) putative TtuD3 hydroxypyruvate reductase [Sinorhizobium meliloti]
-
- gi|15596696|ref|NP_250190.1|_4:146 (NC_002516) conserved hypothetical protein [Pseudomonas aeruginosa]
- gi|11347789|pir||E83459 conserved hypothetical protein PA1499 [imported] - Pseudomonas aeruginosa (strain PAO1)
- gi|9947454|gb|AAG04888.1|AE004578_10 (AE004578) conserved hypothetical protein [Pseudomonas aeruginosa]
-
- gi|4033487sp|Q44472|TUD4_AGRVI_19:165 Putative hydroxypyruvate reductase
- gi|805293|gb|AAA68699.1| (U25634) putative hydroxypyruvate reductase; inducible by tartrate; Method: conceptual translation supplied by author [Rhizobium vitis]
- gi|1585264|prf||2124372D ttuD gene [Rhizobium vitis]
-
- gi|15644333|ref|NP_229385.1|_1:150 (NC_000853) glycerate kinase, putative [Thermotoga maritima]
- gi|7462843|pir||A72236 hypothetical protein TM1585 - Thermotoga maritima (strain MSB8)
- gi|4982155|gb|AAD36652.1|AE001803_5 (AE001803) glycerate kinase, putative [Thermotoga maritima]
-
- gi|16082522|ref|NP_393931.1|_11:161 (NC_002578) Predicted glycerate kinase [Thermoplasma acidophilum]
-
- gi|15967047|ref|NP_387400.1|_34:178 (NC_003047) PUTATIVE HYDROXYPYRUVATE REDUCTASE PROTEIN [Sinorhizobium meliloti]
- gi|15076320|emb|CAC47873.1| (AL591793) PUTATIVE HYDROXYPYRUVATE REDUCTASE PROTEIN [Sinorhizobium meliloti]
-
- gi|16119561|ref|NP_396267.1|_5:147 (NC_003064) AGR_pAT_bx66p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
- gi|17938918|ref|NP_535706.1| (NC_003306) hydroxypyruvate reductase [Agrobacterium tumefaciens str. C58 (Dupont)] [Agrobacterium tumefaciens str. C58 (U. Washington)]
- gi|15162117|gb|AAK90708.1| (AE007902) AGR_pAT_bx66p [Agrobacterium tumefaciens str. C58 (Cereon)]
- gi|17743779|gb|AAL46022.1| (AE008955) hydroxypyruvate reductase [Agrobacterium tumefaciens str. C58 (U. Washington)]
-
- gi|18976396|ref|NP_577753.1|_15:173 (NC_003413) putative glycerate kinase [Pyrococcus furiosus DSM 3638]
- gi|18891922|gb|AAL80148.1| (AE010128) putative glycerate kinase [Pyrococcus furiosus DSM 3638]
-
- gi|1907334|gb|AAB66496.1|_11:162 (U87316) putative glycerate kinase [Methylobacterium extorquens]
-
- gi|10639623|emb|CAC11595.1|_3:138 (AL445064) glycerate kinase related protein [Thermoplasma acidophilum]
-
- gi|20894723|ref|XP_135143.1|_29:202 (XM_135143) similar to CG9886 gene product [Mus musculus]
-
- gi|13541614|ref|NP_111302.1|_12:161 (NC_002689) Predicted glycerate kinase [Thermoplasma volcanium]
- gi|14325013|dbj|BAB59939.1| (AP000993) glycerate kinase [Thermoplasma volcanium]
-
- gi|19388000|gb|AAH25834.1|_29:202 (BC025834) similar to hypothetical protein [Mus musculus]
- gi|19684145|gb|AAH25935.1| (BC025935) similar to hypothetical protein [Mus musculus]
- gi|21620001|gb|AAH33063.1| (BC033063) Unknown (protein for MGC:37851) [Mus musculus]
-
- gi|18312544|ref|NP_559211.1|_18:167 (NC_003364) conserved hypothetical protein [Pyrobaculum aerophilum]
- gi|18160010|gb|AAL63393.1| (AE009815) conserved hypothetical protein [Pyrobaculum aerophilum]
-
- gi|17545205|ref|NP_518607.1|_5:152 (NC_003295) PUTATIVE HYDROXYPYRUVATE REDUCTASE OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]
- gi|17427496|emb|CAD14014.1| (AL646059) PUTATIVE HYDROXYPYRUVATE REDUCTASE OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]
-
- gi|14521745|ref|NP_127221.1|_4:153 (NC_000868) hypothetical protein [Pyrococcus abyssi]
- gi|7518011|pir||E75001 hypothetical protein PAB1021 - Pyrococcus abyssi (strain Orsay)
- gi|5458965|emb|CAB50451.1| (AJ248288) hypothetical protein [Pyrococcus abyssi]
-
- gi|14590403|ref|NP_142469.1|_4:158 (NC_000961) hypothetical protein [Pyrococcus horikoshii]
- gi|7518673|pir||B71162 hypothetical protein PH0495 - Pyrococcus horikoshii
- gi|3256900|dbj|BAA29583.1| (AP000002) 440aa long hypothetical protein [Pyrococcus horikoshii]
-
- gi|4033482sp|P70788|TUD3_AGRVI_2:112 Putative hydroxypyruvate reductase
- gi|984369|gb|AAB61624.1| (U32375) enzyme degrading primary tartrate degradation product [Rhizobium vitis]
-
- gi|19920578|ref|NP_608684.1|_8:177 (NM_134840) CG9886 gene product [Drosophila melanogaster]
- gi|7295954|gb|AAF51252.1| (AE003583) CG9886 gene product [Drosophila melanogaster]
- gi|16769768|gb|AAL29103.1| (AY061555) LP09309p [Drosophila melanogaster]
-
- gi|15897575|ref|NP_342180.1|_2:141 (NC_002754) Glycerate kinase, putative [Sulfolobus solfataricus]
- gi|6015809|emb|CAB57636.1| (Y18930) hypothetical protein [Sulfolobus solfataricus]
- gi|13813834|gb|AAK40970.1| (AE006694) Glycerate kinase, putative [Sulfolobus solfataricus]
-
- gi|15922355|ref|NP_378024.1|_4:145 (NC_003106) 399aa long conserved hypothetical protein [Sulfolobus tokodaii]
- gi|15623144|dbj|BAB67133.1| (AP000988) 399aa long conserved hypothetical protein [Sulfolobus tokodaii]
-
- gi|14601127|ref|NP_147655.1|_2:107 (NC_000854) hypothetical protein [Aeropyrum pernix]
- gi|7516171|pir||D72697 hypothetical protein APE0996 - Aeropyrum pernix (strain K1)
- gi|5104665|dbj|BAA79980.1| (AP000060) 400aa long hypothetical protein [Aeropyrum pernix]
-
- gi|22405563|gb|ZP_00000441.1|_10:160 (NZ_AAAA01000043) hypothetical protein [Ferroplasma acidarmanus]
-
- gi|21300335|gb|EAA12480.1|_67:223 (AAAB01008964) agCP11255 [Anopheles gambiae str. PEST]
-
- gi|15807636|ref|NP_294881.1|_2:142 (NC_001263) hydroxypyruvate reductase, putative [Deinococcus radiodurans]
-
- gi|17987853|ref|NP_540487.1|_24:126 (NC_003317) PUTATIVE HYDROXYPYRUVATE REDUCTASE [Brucella melitensis]
- gi|17983583|gb|AAL52751.1| (AE009592) PUTATIVE HYDROXYPYRUVATE REDUCTASE [Brucella melitensis]
-
- gi|21314996|gb|AAH30732.1|_5:75 (BC030732) Unknown (protein for MGC:37913) [Mus musculus]
-
- gi|13676533|dbj|BAB41180.1|_5:75 (AB060262) hypothetical protein [Macaca fascicularis]
-
- gi|18676755|dbj|BAB85018.1|_5:75 (AK074215) unnamed protein product [Homo sapiens]
-
- gi|21687104|ref|NP_660305.1|_30:130 (NM_145262) similar to CG9886 gene product [Homo sapiens]
- gi|18256912|gb|AAH21896.1|AAH21896 (BC021896) Unknown (protein for MGC:9528) [Homo sapiens]
-
- gi|21542484sp|Q09235|YQ42_CAEEL_1:101 Hypothetical protein C13B9.2 in chromosome III
- gi|20198777|gb|AAA62515.2| (U21309) Hypothetical protein C13B9.2 [Caenorhabditis elegans]
10 20 30 40 50
| | | | |
1 MFDPESLKKLAIEIVKKSIEAVFPDRAVKETL.....PKLN.....LDR.....VILVAVGKAAW
2 ---IANPRQFLESLFASAVSAADPERVIAANL.....PERP.....KGR.....TVVIGAGKGAA
3 -WNDTRAKDALNRIFMAAVASADPAKVLQKHL.....PSPP.....KGR.....CVVVGAGKASA
4 -WNDTRAKDALNRIFMAAVASADPAKVLQKHL.....PSPP.....KGR.....CVVVGAGKASA
5 ----LDPKAFLISIFDAAVAAADPERTIRDHL.....PVRP.....KGR.....TIVIGAGKGSA
6 --PQADHRLLLRAMFDAAVASAQPARCLAPHL.....PAPP.....RGR.....TIVIGAGKASA
7 -----EDRDFLSELFEAAVGAADPKLALRARL.....PQRP.....RGR.....TVVVGAGKGAA
8 -----DPRAFLTELFNTAVAAGHPYQVLADHL.....PEDR.....SGR.....AIVIGAGKAAG
9 -WNDVSARQVLRRIFDAAVASADPKIAVVNNL.....PERP.....RGR.....CVVVGAGKASA
10 MFDPESLKKLAIEIVKKSIEAVFPDRAVKETL.....PKLN.....LDR.....VILVAVGKAAW
11 -IYTSERRQFILDILKRTFEDLEPSRVMGNAI.....GDLDvsr..YSR.....IFVMGFGKASY
12 --TSIEPRPFLISLFEAAVAAADPEAAIRAHL.....PARP.....KGR.....TIVVGAGKAAS
13 ----ADTRVFLSELFRAAVAAADPYEAIKANL.....PREP.....KGR.....TVVIGAGKASV
14 ---DVRTKEIALAMMEEAIKSADPYEAVKRVL.....RIEGd12qiKGD.....IYVLAFGKAAC
15 ---HAERRALLSSILDEAIAAAHPRKCLAGHL.....PAPT.....SGR.....LIILGAGKAGG
16 ----------------RTFEDLEPSRVMGNAI.....GDLDvsr..YSR.....IFVMGFGKASY
17 -TSGMALAEQARQLFDSAVGAVQPGPMLQRTL.....SLDP.....SGRq14enLYLVGFGKAVL
18 --AYDERRAFIFRTLNEVFKDFEPNKVTEKAV.....NEID.....LNKyag..VYVIGFGKAAY
19 -TSGMALAEQARQLFDSAVGAVQPGPMLQRTL.....SLDP.....SGRq14enLYLVGFGKAVL
20 ----------LVGALEEALSAADPYKAVASHV.....KRAGg12svRGR.....AHVVGFGKASE
21 ---RAAARALLLESYAAAVAAADPLKIVAGFL.....PPPHa....GGR.....TLVVGAGKAAA
22 ---------IALRLVKAAIRAADPYKAVINSV.....RVEGn12eiKGK.....VYVLAFGKAAC
23 ----MDIREIGLRLVGEAIKAADPYRAVLNAV.....KVSDd12eiKGK.....VYVIALGKAAC
24 --------------------------------.....----.....-GR.....CVVIGAGKASA
25 --------EQMRQIFVQAVNAVHPEKVFADFQ.....KFDLr23isGKT.....CHIVGFGKAVL
26 ------------DIVDKILEYTDPYKALQEKV.....RVYNn11ipFKK.....PILISIGKASL
27 -------------IIEKILTFSDPYIALDERVv11dgNHFP.....YTK.....PAIIAVGKASY
28 --------------------------------.....----.....---.....--VLALGKGSL
29 --GTNSRRVYALEKIQNAINNLHPSAAMSRNF.....NVDTek...FDR.....VYVIGFGKASF
30 ----------LRELFLCGVEAVKPKSLFDGRH.....SSAGsi9hdHKR.....YHVVGFGKAVL
31 -----DPRALLEQAYRAALDSASPARLLAPHL.....SGPP.....--P.....AFILAFGKASL
32 ---IADPKKFLTSLFDAAVAAADPELVIRANL.....PEKP.....KGR.....TIV--------
33 --------------------------------.....----.....---.....-----------
34 --------------------------------.....----.....---.....-----------
35 --------------------------------.....----.....---.....-----------
36 --SSMALAEQARQLFESAVGAVLPGPMLHRAL.....SLDP.....GGRq14qnLYLVGFGKAVL
37 --------------------------------.....----.....---.....-----------
60 70 80 90
| | | |
1 RMAKAAYEVLGKK.I.....RKGVVVTKYG....H.S.....EGPIDDFE.....IYE.AGHPVP
2 QMARALESVWEGP.L.....-SGVVVTRYG....F.G.....AH-CKNIE.....VLE.ASHPLP
3 AMAAALEEAWPHV.D.....LSGVVVTRYG....H.A.....VP-TSRIE.....IIE.ASHPVP
4 AMAAALEEAWPHV.D.....LSGVVVTRYG....H.A.....VP-TSRIE.....IIE.ASHPVP
5 QMAAAFEKVWDGP.I.....-EGLVVTRYG....Y.G.....AK-CERIE.....IIE.AAHPVP
6 AMAQALEAHWPGP.L.....-EGLVITRYG....Y.A.....VP-CERVE.....IVE.AAHPVP
7 QLAAAFESLWGGP.L.....-EGVVVTRYG....Y.A.....VH-CDRIR.....VIE.AAHPVP
8 AMAEVVEKHWQGE.I.....-QGLVVAPYR....Y.G.....AQ-CSRIE.....VVE.ASHPVP
9 AMAAAVDAAWPDV.D.....LSGIVVTRYG....H.A.....VP-AGRIE.....ILE.ASHPVP
10 RMAKAAYEVLGKK.I.....RKGVVVTKYG....H.S.....EGPIDDFE.....IYE.AGHPVP
11 EMSEGIRDHVRKK.L.....AYAGIIVPVD....Q.D.....VSGFPELE.....ILR.GTHPYT
12 QMAAAFERLWDGP.L.....-AGAVVARHG....P.V.....EK-CGRIR.....VLQ.SAHPVP
13 EMARAFDALWKGS.L.....-EGVVVTKHG....T.R.....SS-CSRIE.....VIE.AAHPVP
14 SMAKAVEEILGDR.I.....REGIAVTKYG....Y.S.....LPLIKKIR.....VIE.AGHPIP
15 SMAAVASEFYRQE.Hgv6drIVGLAVARHG....Y.G.....EE-APGIR.....MVE.AGHPVP
16 EMSEGIRDHVRKK.L.....AYAGIIVPVD....Q.D.....VSGFPELE.....ILR.GTHPYT
17 GMAAAAEELLAQH.L.....VQGVISVPKG....I.Ra12mlLKPHSRIQ.....VFEgAEDNLP
18 EMYLGVREHVKRK.L.....KYAGIIIPSD....Q.E.....VQYLPELD.....ILR.GTHPLT
19 GMAAAAEELLAQH.L.....VQGVISVPKG....I.Ra12mlLKPHSRVQ.....VFEgAEDNLP
20 KMAEALVDVLGDL.A.....AGGVVISPRG....S.G.....R--LGPVE.....VVK.GDHPVP
21 SMALAVERAYAGRaQ.....IEGLVVTRYA....H.G.....LP-TDHIR.....VIE.AGHPVP
22 DMARAIEEILDVE.-.....-DGVAVTKYG....Y.G.....KE-LKKIR.....VIE.AGHPIP
23 EMARAIEDILDVE.-.....-DGVAVTKYG....Y.G.....KE-LKRIK.....VIE.AGHPIP
24 AMAAALDTVWSDV.D.....LSGVVVTRYG....H.A.....VP-SGRIR.....IIE.ASHPVP
25 GMANKVQQDLGAT.S.....AGGVLSVPVNtlkqF.Q.....QPVAPGLV.....VHEgAANNLP
26 PMARFFRERMELK.-.....-AKLIVTPKG....T.N.....GK---END.....VIE.AGHPLP
27 KMAKFFIDKLKDV.-.....-KGLVILPKG....S.Y.....IS-LPKVE.....VIE.STHPDI
28 QMARGALECLEPE.-.....-GGVVVKPRG....M.T.....GN-VEGLE.....VVE.GSHPLP
29 SMYSGIRERVLKK.L.....SYAGIIIPDDev..-.H.....NESYPELE.....VLR.GTHPYV
30 GMAVQLERHLGSR.L.....SGGCISIPTG....T.Ge10ftLSPSTAIE.....VIEcARNNLP
31 PMARAALAAYPGV.-.....-PTLVVPPAG....TaD.....LSAPPEAV.....VMP.GSHPVP
32 -------------.-.....----------....-.-.....--------.....-IE.AAHPVP
33 -------------.-.....----------....-.-.....--PHSRVQ.....VFEgAEDNLP
34 -------------.-.....----------....-.-.....--PHSRVQ.....VFEgAEDNLP
35 -------------.-.....----------....-.-.....--PHSRVQ.....VFEgAEDNLP
36 GMAAAAEELLGQH.L.....VQGVISVPKG....I.R.....AAPIPPVT.....LEE.KQ----
37 -MAKGARDQLKSS.L.....LQKTIVIAPE....Q.Q.....KGIENELEndteiLYG.ARDNLP
100 110 120 130 140 150
| | | | | |
1 DENTIKTTRRVLELVDQLN.ENDTVLFLLSGGGSSLFELPLEGVSLEEIQKLTSALLK
2 DEGGLKASKRLLAAVSGLT.GDDLVVALICGGGSALLPAPPPALSLEDEIAVNRALL-
3 DDKSAEAAKRILAAVEGLT.ADDMVIALISGGGSALMVAPAEGMTLADKMAVNRALL-
4 DDKSAEAAKRILAAVEGLT.ADDMVIALISGGGSALMVAPAEGMTLADKMAVNRALL-
5 DAAGLEASRRLLAKVQGLT.EDDLVVALISGGGSALLPSPAAGLTLADEIAVNEALL-
6 DAAGLQATARMRRLVSGLT.EDDLVIALISGGGSSLLVAPGEGLTLADKQAVNAALLQ
7 DCNGLIASHALFEAVRGLT.PDDLVVALFCGGGSALLPCPPEELALEDEIALNRALL-
8 DDAGERVARRVLELISGLN.ESDRVIFLLSGGGSALLSLPAEGIGLADKQAVNKALLK
9 DEMSIKAAEKIFAAVQGLG.PDDLVVALISGGGSSLLVSPTGKMTLTDKRAVNQALL-
10 DENTIKTTRRVLELVDQLN.ENDTVLFLLSGGGSSLFELPLEGVSLEEIQKLTSALLK
11 SSLSVSSSRTLLSKVKP-G.PNDAVIVLISGGGSSLFEIPEEGITIDQISEISKKMMQ
12 DEAGLAASAALLETVGGLT.ADDLVVALISGGGSALLPAPPGGLTLEDEIAVNKALL-
13 DRAGFVASRRLLDAVSDLT.EDDLVVALISGGGSSLLALPCEGLTLDDEIAVAKMLL-
14 DENSVKGAKLGVELAKKVK.ENDILLVLISGGGSALFTLPEDGISLEDKIKTNELLLK
15 DAAGIEATKEALALAASAG.PEDEVLVLLSGGGSANWIAPAGNLTLAEKQAITKALLR
16 SSLSVSSSRTLLSKVKP-G.PNDAVIVLISGGGSSLFEIPEEGITIDQISEISKKMMQ
17 DRDALRAALTIQQLAEGLT.ADDLLLVLISGGGSALLPAPIPPVTLEEKQMLTKLL--
18 STLSVTSSKKLLSKARP-S.ANDLVLVLISGGGSSLFEIPQEGITIDQMASISRAMMD
19 DRDALRAALTIQQLAEGLT.ADDLLLVLISGGGSALLPAPIPPVTLEEKQMLTKLL--
20 GADTLVASRRLLEYLEGVG.ENDVVFVVISGGGSALFEVPVEGMELGDIARISAELMR
21 DEAGEQAAQAIFDRVSALT.EHDRLIVLVSGGGSSLLSLPAEGVPMADLKAVTRELLR
22 DENSIRGAIEGLKLLEKVK.EEDIVFVLISGGGSALFELPEDGISLEDLKLTNELLLK
23 DEKSILGAKEALSILNRAR.ENDIVFILISGGGSALFELPEEGISLEDLKLTTDLLLK
24 DDMSVEAAVRIIGAVRDLG.PDDLVIALISGGGSSLLVSPAAGMTLADKKAVNKALL-
25 DENALKAAREIKQLAEKMT.AQDILFVFISGGGSALLPLPRSPLTLEDKRSIADKLMK
26 DENSIKAGKRMIELLAN-E.DYDLVIFAISGGASALVEY--SEIPLDELKIINKVLV-
27 SELSFKAGTEVIKFLKN-E.DYDLLIFLLSGGASALMEY--SNVPYEILRDINEKLVK
28 DEWSLRAGRRLLEWAGSAG.EGDNVVVLVSGGGSALAEVPMEGLALEDLREVNMLLLK
29 SSLSVESSKKLLSHLDRLN.QNDLVIVLISGGGSSLFEILETGIDVNDLKDISAEIME
30 DEGSLMAAKKIKQIAHSMT.SDDVLCVLVSGGGSALLCLPKEPITLEEKLQLIKS---
31 DERSXAAAEEALRQLGALR.PDQEALILVSGGGSALLAAP-DGVTLAEKQALTRELLR
32 DGAGLAASRRLFNAVSGLS.EDDLVVALISGGGSALLPSPPEGMTLEDEIAVNKALL-
33 DRDALRAALTIQQLAEGLT.ADDLLLVLISGGGSALLPAPIPPVTLEEKQMLTKLL--
34 DRDALRAALAIRQLAEGLT.ADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTRLL--
35 DRDALRAALAIQQLAEGLT.ADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTRLL--
36 -------------------.--------------------------------------
37 DEKSVFATRKVISEIRDFDsESTIFLFLISGGGSALLTSPSAPLDLAEKLETIR----