(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0173 Mycothiol deacetylase, M. tuberculosis
    • gi|21323755|dbj|BAB98381.1|_1:289 (AP005277) Uncharacterized proteins, LmbE homologs [Corynebacterium glutamicum ATCC 13032]
    • gi|15608310|ref|NP_215686.1|_1:302 (NC_000962) hypothetical protein Rv1170 [Mycobacterium tuberculosis H37Rv]
    • gi|15840613|ref|NP_335650.1| (NC_002755) lmbE-related protein [Mycobacterium tuberculosis CDC1551]
    • gi|7476663|pir||B70875 hypothetical protein Rv1170 - Mycobacterium tuberculosis (strain H37RV)
    • gi|2695954|emb|CAA15847.1| (AL010186) hypothetical protein Rv1170 [Mycobacterium tuberculosis H37Rv]
    • gi|13880795|gb|AAK45464.1| (AE006998) lmbE-related protein [Mycobacterium tuberculosis CDC1551]
    • gi|15827787|ref|NP_302050.1|_1:303 (NC_002677) conserved hypothetical protein [Mycobacterium leprae]
    • gi|13093339|emb|CAC30445.1| (AL583922) conserved hypothetical protein [Mycobacterium leprae]
    • gi|19552213|ref|NP_600215.1|_1:283 (NC_003450) COG2120:Uncharacterized proteins, LmbE homologs [Corynebacterium glutamicum]
    • gi|21223340|ref|NP_629119.1|_1:289 (NC_003888) conserved hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|20520968|emb|CAD30952.1| (AL512667) conserved hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|15608222|ref|NP_215598.1|_2:286 (NC_000962) hypothetical protein Rv1082 [Mycobacterium tuberculosis H37Rv]
    • gi|15840518|ref|NP_335555.1| (NC_002755) lmbE protein [Mycobacterium tuberculosis CDC1551]
    • gi|7476624|pir||H70894 hypothetical protein Rv1082 - Mycobacterium tuberculosis (strain H37RV)
    • gi|2896719|emb|CAA17198.1| (AL021897) hypothetical protein Rv1082 [Mycobacterium tuberculosis H37Rv]
    • gi|13880694|gb|AAK45369.1| (AE006992) lmbE protein [Mycobacterium tuberculosis CDC1551]
    • gi|15828284|ref|NP_302547.1|_2:286 (NC_002677) conserved hypothetical protein [Mycobacterium leprae]
    • gi|699274|gb|AAA63037.1| (U15183) lmbE [Mycobacterium leprae]
    • gi|13093977|emb|CAC31907.1| (AL583925) conserved hypothetical protein [Mycobacterium leprae]
    • gi|21225893|ref|NP_631672.1|_3:275 (NC_003888) conserved hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|11323218|emb|CAC16965.1| (AL450350) conserved hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|21223496|ref|NP_629275.1|_4:285 (NC_003888) conserved hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|9967638|emb|CAC05756.1| (AL391751) conserved hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|14521743|ref|NP_127219.1|_28:256 (NC_000868) hypothetical protein [Pyrococcus abyssi]
    • gi|7518097|pir||C75001 hypothetical protein PAB1341 - Pyrococcus abyssi (strain Orsay)
    • gi|5458963|emb|CAB50449.1| (AJ248288) hypothetical protein [Pyrococcus abyssi]
    • gi|14590405|ref|NP_142471.1|_32:261 (NC_000961) hypothetical protein [Pyrococcus horikoshii]
    • gi|7518675|pir||F71162 hypothetical protein PH0499 - Pyrococcus horikoshii
    • gi|3256904|dbj|BAA29587.1| (AP000002) 272aa long hypothetical protein [Pyrococcus horikoshii]
    • gi|18976726|ref|NP_578083.1|_29:256 (NC_003413) hypothetical protein [Pyrococcus furiosus DSM 3638]
    • gi|18892310|gb|AAL80478.1| (AE010159) hypothetical protein [Pyrococcus furiosus DSM 3638]
    • gi|21430034|gb|AAM50695.1|_136:339 (AY118835) GM02889p [Drosophila melanogaster]
    • gi|21399450|ref|NP_655435.1|_2:232 (NC_003995) DUF158, Uncharacterized LmbE-like protein, COG2120 [Bacillus anthracis A2012] [Bacillus anthracis str. A2012]
    • gi|19552326|ref|NP_600328.1|_5:285 (NC_003450) COG2120:Uncharacterized proteins, LmbE homologs [Corynebacterium glutamicum]
    • gi|21323867|dbj|BAB98493.1| (AP005277) Uncharacterized proteins, LmbE homologs [Corynebacterium glutamicum ATCC 13032]
    • gi|15805477|ref|NP_294173.1|_9:277 (NC_001263) conserved hypothetical protein [Deinococcus radiodurans]
    • gi|7471625|pir||F75517 conserved hypothetical protein - Deinococcus radiodurans (strain R1)
    • gi|6458132|gb|AAF10027.1|AE001904_3 (AE001904) conserved hypothetical protein [Deinococcus radiodurans]
    • gi|7300580|gb|AAF55732.1|_136:364 (AE003728) CG4433 gene product [Drosophila melanogaster]
    • gi|15615882|ref|NP_244186.1|_1:192 (NC_002570) BH3320~unknown conserved protein [Bacillus halodurans]
    • gi|10175943|dbj|BAB07039.1| (AP001518) BH3320~unknown conserved protein [Bacillus halodurans]
    • gi|16081168|ref|NP_389828.1|_3:214 (NC_000964) Uncharacterized conserved protein [Bacillus subtilis]
    • gi|15614245|ref|NP_242548.1|_2:214 (NC_002570) BH1682~unknown conserved protein [Bacillus halodurans]
    • gi|10174299|dbj|BAB05401.1| (AP001512) BH1682~unknown conserved protein [Bacillus halodurans]
    • gi|16079304|ref|NP_390128.1|_5:220 (NC_000964) alternate gene name: jojG~similar to hypothetical proteins [Bacillus subtilis]
    • gi|1176704sp|P42981|YPJG_BACSU Hypothetical protein ypjG
    • gi|7474677|pir||F69937 conserved hypothetical protein ypjG - Bacillus subtilis
    • gi|755605|gb|AAA92876.1| (L38424) unknown [Bacillus subtilis]
    • gi|1146236|gb|AAB38444.1| (L47709) putative [Bacillus subtilis]
    • gi|2634665|emb|CAB14163.1| (Z99115) alternate gene name: jojG~similar to hypothetical proteins [Bacillus subtilis]
    • gi|20806745|ref|NP_621916.1|_8:241 (NC_003869) conserved hypothetical protein [Thermoanaerobacter tengcongensis]
    • gi|20515203|gb|AAM23520.1| (AE012995) conserved hypothetical protein [Thermoanaerobacter tengcongensis]
    • gi|21674240|ref|NP_662305.1|_6:213 (NC_002932) conserved hypothetical protein [Chlorobium tepidum TLS]
    • gi|13899165|gb|AAG12428.1| (AY005138) unknown [Chlorobium tepidum]
    • gi|21647407|gb|AAM72647.1| (AE012899) conserved hypothetical protein [Chlorobium tepidum TLS]
    • gi|3089177|gb|AAC14880.1|_6:213 (AF060080) hypothetical protein [Chlorobium tepidum]
    • gi|20808518|ref|NP_623689.1|_43:329 (NC_003869) conserved hypothetical protein [Thermoanaerobacter tengcongensis]
    • gi|20517140|gb|AAM25293.1| (AE013159) conserved hypothetical protein [Thermoanaerobacter tengcongensis]
    • gi|2792327|gb|AAC01723.1|_3:251 (AF040570) negative regulatorly protein [Amycolatopsis mediterranei]
    • gi|4758922|ref|NP_004269.1|_38:240 (NM_004278) phosphatidylinositol glycan, class L [Homo sapiens]
    • gi|14916637sp|Q9Y2B2|PIGL_HUMAN N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (Phosphatidylinositol-glycan biosynthesis, class L protein) (PIG-L)
    • gi|4239986|dbj|BAA74775.1| (AB017165) PIG-L [Homo sapiens]
    • gi|16120434|ref|NP_403747.1|_68:280 (NC_003143) hypothetical protein [Yersinia pestis]
    • gi|15978196|emb|CAC88949.1| (AJ414141) hypothetical protein [Yersinia pestis]
    • gi|21956714|gb|AAM83649.1|AE013606_9_31:243 (AE013606) hypothetical [Yersinia pestis KIM]
    • gi|20808337|ref|NP_623508.1|_13:224 (NC_003869) conserved hypothetical protein [Thermoanaerobacter tengcongensis]
    • gi|20516944|gb|AAM25112.1| (AE013144) conserved hypothetical protein [Thermoanaerobacter tengcongensis]
    • gi|20302097|ref|NP_620256.1|_37:239 (NM_138901) phosphatidylinositol glycan, class L [Rattus norvegicus]
    • gi|14916624sp|O35790|PIGL_RAT N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (Phosphatidylinositol-glycan biosynthesis, class L protein) (PIG-L)
    • gi|2225906|dbj|BAA20869.1| (D88364) PIG-L [Rattus norvegicus]
    • gi|15805122|ref|NP_293807.1|_9:231 (NC_001263) conserved hypothetical protein [Deinococcus radiodurans]
    • gi|7471695|pir||G75562 conserved hypothetical protein - Deinococcus radiodurans (strain R1)
    • gi|6457746|gb|AAF09674.1|AE001871_6 (AE001871) conserved hypothetical protein [Deinococcus radiodurans]
    • gi|15923557|ref|NP_371091.1|_1:214 (NC_002758) conserved hypothetical protein [Staphylococcus aureus subsp. aureus Mu50]
    • gi|15926245|ref|NP_373778.1| (NC_002745) conserved hypothetical protein [Staphylococcus aureus subsp. aureus N315]
    • gi|21282251|ref|NP_645339.1| (NC_003923) conserved hypothetical protein [Staphylococcus aureus subsp. aureus MW2]
    • gi|13700459|dbj|BAB41756.1| (AP003131) conserved hypothetical protein [Staphylococcus aureus subsp. aureus N315]
    • gi|14246335|dbj|BAB56729.1| (AP003359) conserved hypothetical protein [Staphylococcus aureus subsp. aureus Mu50]
    • gi|21203687|dbj|BAB94387.1| (AP004823) conserved hypothetical protein [Staphylococcus aureus subsp. aureus MW2]
    • gi|21219326|ref|NP_625105.1|_13:240 (NC_003888) conserved hypothetical protein SCF43.15c. [Streptomyces coelicolor A3(2)]
    • gi|6714739|emb|CAB66204.1| (AL136502) conserved hypothetical protein SCF43.15c. [Streptomyces coelicolor A3(2)]
    • gi|21401395|ref|NP_657380.1|_3:187 (NC_003995) DUF158, Uncharacterized LmbE-like protein, COG2120 [Bacillus anthracis A2012] [Bacillus anthracis str. A2012]
    • gi|21288859|gb|EAA01152.1|_2:199 (AAAB01008987) ebiP7885 [Anopheles gambiae str. PEST]
    • gi|21401735|ref|NP_657720.1|_1:191 (NC_003995) DUF158, Uncharacterized LmbE-like protein, COG2120 [Bacillus anthracis A2012] [Bacillus anthracis str. A2012]
    • gi|15839710|ref|NP_334747.1|_7:208 (NC_002755) hypothetical protein [Mycobacterium tuberculosis CDC1551]
    • gi|13879834|gb|AAK44561.1| (AE006940) hypothetical protein [Mycobacterium tuberculosis CDC1551]
    • gi|21225398|ref|NP_631177.1|_13:239 (NC_003888) conserved hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|9885214|emb|CAC04222.1| (AL391515) conserved hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|15607464|ref|NP_214837.1|_7:208 (NC_000962) hypothetical protein Rv0323c [Mycobacterium tuberculosis H37Rv]
    • gi|7476304|pir||D70526 hypothetical protein Rv0323c - Mycobacterium tuberculosis (strain H37RV)
    • gi|3261802|emb|CAB09612.1| (Z96800) hypothetical protein Rv0323c [Mycobacterium tuberculosis H37Rv]
    • gi|3859093|emb|CAA77139.1|_2:177 (Y18353) hypothetical protein [Thermus thermophilus]
    • gi|20093927|ref|NP_613774.1|_3:194 (NC_003551) Uncharacterized protein [Methanopyrus kandleri AV19]
    • gi|19886874|gb|AAM01704.1| (AE010343) Uncharacterized protein [Methanopyrus kandleri AV19]
    • gi|20091295|ref|NP_617370.1|_101:298 (NC_003552) conserved hypothetical protein [Methanosarcina acetivorans str. C2A] [Methanosarcina acetivorans C2A]
    • gi|19916420|gb|AAM05850.1| (AE010939) conserved hypothetical protein [Methanosarcina acetivorans str. C2A] [Methanosarcina acetivorans C2A]
    • gi|21323850|dbj|BAB98476.1|_11:201 (AP005277) Uncharacterized proteins, LmbE homologs [Corynebacterium glutamicum ATCC 13032]
    • gi|19552309|ref|NP_600311.1|_9:199 (NC_003450) COG2120:Uncharacterized proteins, LmbE homologs [Corynebacterium glutamicum]
    • gi|15921101|ref|NP_376770.1|_2:197 (NC_003106) 221aa long conserved hypothetical protein [Sulfolobus tokodaii]
    • gi|15621886|dbj|BAB65879.1| (AP000984) 221aa long conserved hypothetical protein [Sulfolobus tokodaii]
    • gi|18309472|ref|NP_561406.1|_47:307 (NC_003366) conserved hypothetical protein [Clostridium perfringens]
    • gi|18144149|dbj|BAB80196.1| (AP003187) conserved hypothetical protein [Clostridium perfringens str. 13]
    • gi|15807731|ref|NP_285386.1|_59:345 (NC_001264) conserved hypothetical protein [Deinococcus radiodurans]
    • gi|7471327|pir||A75600 conserved hypothetical protein - Deinococcus radiodurans (strain R1)
    • gi|6460546|gb|AAF12252.1|AE001862_78 (AE001862) conserved hypothetical protein [Deinococcus radiodurans]
    • gi|19114799|ref|NP_593887.1|_29:234 (NC_003424) putative N-acetylglucosaminyl phosphatidylinositol deacetylase [Schizosaccharomyces pombe]
    • gi|14916630sp|Q9HDW9|PIGL_SCHPO Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
    • gi|12140655|emb|CAC21467.1| (AL512549) putative N-acetylglucosaminyl phosphatidylinositol deacetylase [Schizosaccharomyces pombe]
    • gi|15899615|ref|NP_344220.1|_5:181 (NC_002754) Conserved hypothetical protein [Sulfolobus solfataricus]
    • gi|13816270|gb|AAK43010.1| (AE006882) Conserved hypothetical protein [Sulfolobus solfataricus]
    • gi|17938345|ref|NP_535134.1|_27:250 (NC_003305) conserved hypothetical protein [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|17743154|gb|AAL45450.1| (AE009394) conserved hypothetical protein [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15890334|ref|NP_356006.1|_42:265 (NC_003063) AGR_L_453p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|15158542|gb|AAK88791.1| (AE008221) AGR_L_453p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|21231098|ref|NP_637015.1|_10:202 (NC_003902) conserved hypothetical protein [Xanthomonas campestris pv. campestris str. ATCC 33913]
    • gi|21112731|gb|AAM40939.1| (AE012266) conserved hypothetical protein [Xanthomonas campestris pv. campestris str. ATCC 33913]
    • gi|16264499|ref|NP_437291.1|_6:200 (NC_003078) conserved hypothetical protein, possibly membrane-associated [Sinorhizobium meliloti]
    • gi|15140636|emb|CAC49151.1| (AL603644) conserved hypothetical protein, possibly membrane-associated [Sinorhizobium meliloti]
    • gi|6729666|emb|CAB67717.1|_1:186 (AJ271405) hypothetical protein [Streptomyces rochei]
    • gi|15806222|ref|NP_294927.1|_2:207 (NC_001263) LmbE-related protein [Deinococcus radiodurans]
    • gi|7473100|pir||B75424 LmbE-related protein - Deinococcus radiodurans (strain R1)
    • gi|6458943|gb|AAF10773.1|AE001969_2 (AE001969) LmbE-related protein [Deinococcus radiodurans]
    • gi|21242858|ref|NP_642440.1|_2:211 (NC_003919) conserved hypothetical protein [Xanthomonas axonopodis pv. citri str. 306]
    • gi|21108349|gb|AAM36976.1| (AE011848) conserved hypothetical protein [Xanthomonas axonopodis pv. citri str. 306]
    • gi|15965517|ref|NP_385870.1|_5:212 (NC_003047) CONSERVED HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
    • gi|15074698|emb|CAC46343.1| (AL591788) CONSERVED HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
    • gi|15131497|emb|CAC48365.1|_4:236 (Y16952) hypothetical protein [Amycolatopsis mediterranei]
    • gi|21234046|ref|NP_639623.1|_2:167 (NC_003903) hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|21234304|ref|NP_639915.1| (NC_003903) hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|13620532|emb|CAC36570.1| (AL590463) hypothetical protein [Streptomyces coelicolor]
    • gi|13620791|emb|CAC36831.1| (AL590464) hypothetical protein [Streptomyces coelicolor]
    • gi|13474424|ref|NP_105992.1|_2:179 (NC_002678) hypothetical protein [Mesorhizobium loti]
    • gi|14025177|dbj|BAB51778.1| (AP003006) hypothetical protein [Mesorhizobium loti]
    • gi|15807671|ref|NP_296086.1|_14:192 (NC_001263) Uncharacterized conserved protein [Deinococcus radiodurans]
    • gi|19173356|ref|NP_597159.1|_52:232 (NC_003235) hypothetical protein [Encephalitozoon cuniculi]
    • gi|19170945|emb|CAD26335.1| (AL590448) hypothetical protein [Encephalitozoon cuniculi]
    • gi|15807801|ref|NP_285456.1|_15:197 (NC_001264) hypothetical protein [Deinococcus radiodurans]
    • gi|7472901|pir||G75608 hypothetical protein - Deinococcus radiodurans (strain R1)
    • gi|6460611|gb|AAF12317.1|AE001862_143 (AE001862) hypothetical protein [Deinococcus radiodurans]
    • gi|20881190|ref|XP_126296.1|_10:137 (XM_126296) similar to N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (Phosphatidylinositol-glycan biosynthesis, class L protein) (PIG-L) [Mus musculus]
    • gi|17510221|ref|NP_492873.1|_28:146 (NM_060472) Y52B11C.1.p [Caenorhabditis elegans]
    • gi|7510139|pir||T27111 hypothetical protein Y52B11C.1 - Caenorhabditis elegans
    • gi|3881138|emb|CAA19544.1| (AL023846) Y52B11C.1 [Caenorhabditis elegans]
    • gi|17989171|ref|NP_541804.1|_10:161 (NC_003318) Hypothetical Cytosolic Protein [Brucella melitensis]
    • gi|16740534|gb|AAL27668.1| (AF076290) Bme17 [Brucella melitensis]
    • gi|17985024|gb|AAL54068.1| (AE009716) Hypothetical Cytosolic Protein [Brucella melitensis]
    • gi|21224357|ref|NP_630136.1|_3:260 (NC_003888) hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|7479380|pir||T34705 hypothetical protein SC1C3.13 SC1C3.13 - Streptomyces coelicolor
    • gi|3169039|emb|CAA19237.1| (AL023702) hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|10802729|gb|AAG23586.1|AF244637_1_37:136 (AF244637) hypothetical protein [Carboxydothermus hydrogenoformans] 
              10        20         30         40           50          
              |         |          |          |            |          
   1 MSETPRLLFVHAHPDDESLSNGATIAHY.TS.RGAQVHVVTCTLGEEGEV...IGD...RWA...
   2 -MSGLRLMAIHAHPDDESSKGAATMARY.AA.EGNQVMVVTCTGGERGDI...LNP...AMD...
   3 MSETPRLLFVHAHPDDESLSNGATIAHY.TS.RGAQVHVVTCTLGEEGEV...IGD...RWA...
   4 MSETPRLLFVHAHPDDESLSNGATIAHY.TS.RGAQVQVVTCTLGEEGEV...IGD...RWA...
   5 -------MAIHAHPDDESSKGAATMARY.AA.EGNQVMVVTCTGGERGDI...LNP...AMD...
   6 MTDQLRLMAVHAHPDDESSKGAATMAKY.VS.EGVDVLVVTCTGGERGSI...LNP...KL-...
   7 --SELRLMAVHAHPDDESSKGAATLARY.AD.EGHRVLVVTLTGGERGEI...LNP...AM-...
   8 --SELRLMAVHAHPDDESSKGAATLARY.AD.EGHRVLVVTLTGGERGEI...LNP...AM-...
   9 -DRPLTLMAVHAHPDDEATSTGGVLARY.AA.EGIRTVLVTCTDGGCGDG...PGG...VKP...
  10 -LPGRRLLLVHAHPDDESINNGVTMARY.AA.EGAHVTLVTCTLGERGEV...IPP...ALA...
  11 FKDVEKVLCIEPHPDDCVIGMGGTIKKL.TE.RGIEVIYACMTDGYMGTL...---...---...
  12 FKDAKKVLCIEPHPDDCVIGMGGTIKKL.SD.MGVEVIYVCMTDGYMGTT...---...---...
  13 -EDAKKVICIEPHPDDCAIGMGGTIKKL.SD.EGVEVIYICMTDGYMGTT...---...---...
  14 TACMERVLLITAHPDDECMFFGPLIYSL.TQrQGCQVYILCLSNG-----...---...---...
  15 --SGLHILAFGAHADDVEIGMAGTIAKY.TK.QGYEVGICDLTEADLSSN...---...---...
  16 DLSGARVVAVHAHPDDEAITTGGVLADL.AA.RGADVTVITCTLGEQGEV...IGE...TFA...
  17 --PRATLLVIFAHPDDEAFSVGGTLTHY.AR.QGVRVVLACATRGEAGKI...---...---...
  18 TACMERVLLITAHPDDECMFFGPLIYSL.TQrQGCQVYILCLSNGETTS-...-SD...IIP...
  19 MNQERHVLVIFPHPDDEAFGVSGTIALF.RK.QGVPVTYACLTLGEMGRN...LGN...---...
  20 ----EHVLVILPHPDDESYGVAGLIALN.RK.KDIPVTYACATLGEMGRN...MGD...---...
  21 --SKLDILAFGAHPDDVEIGMGATLYHY.RQ.KGHRVGICNLTKAELSSN...---...---...
  22 -----DVLAFGAHSDDVEIGMGGTIAKF.VK.QEKKVMICDLTEAELSSN...---...---...
  23 MGKKLHIMAVGAHCGDMELVAGGVIAKY.TR.AGHEASIVHLTPGEKG--...---...---...
  24 PIQPVYALAFGAHPDDVELACGATLLKI.MD.EGKPVAVCDLTAGEMGTL...---...---...
  25 PIQPVYALAFGAHPDDVELACGATLLKI.MD.EGKPVAVCDLTAGEMGTL...---...---...
  26 -DPGQRILIIVPHPDDETLGMAGVIQRA.VE.LKRPVKVVVVTSGESYKK...AAM...VFCgkk
  27 -----TLVSFHAHPNDDTTTCGGVLRKA.HE.DGHRVVLVLATRGELGYN...PDG...LLA...
  28 ----QCLLTVHAHPDDEASRGGATVAHY.TA.QGVRAVLVTCTDGGAGEV...LNP...AV-...
  29 -GAESRTLLVIAHPDDEAMFFAPTVLGL.AR.LRHWVYLLCFSAG-----...---...---...
  30 MIPQKTALVVSAHSADFVWRAGGAIALH.VE.QGYQVHIVCLSYGERGE-...-SA...KLW...
  31 MIPQKTALVVSAHSADFVWRAGGAIALH.VE.QGYQVHIVCLSYGERGE-...-SA...KLW...
  32 -LEVKNVLCVQPHPDDNEIGAGGFLSIL.KE.KGAKITFVTVTDGRKGLP...---...---...
  33 PGAGSRALVVIAHPDDEAMFFAPTILGL.AR.LKQQVSLLCFSSG-----...---...---...
  34 TGKGLKLLLIVPHPDDEVYGASGTLMEY.LA.AGESCGLVTLTRGEAGRT...LGL...---...
  35 MTDERHVLVIFPHPDDETFSSAGTLASY.IQ.KGIPVTYACLTLGQMGRN...LGN...---...
  36 PGDWRRALAVVAHPDDLEYGCAAAIAAW.TD.EGREVAYVLATRGEAG--...---...---...
  37 ----RHVLVVFPHPDDEAFAAGGTIRLL.TD.QGVPVTYACGTLGQMGRN...MGK...---...
  38 -----RALLVTAHPDDEVMFFGPTILEL.RR.RQCRVFVLCLSEG-----...---...---...
  39 MKNERHVLIVFPHPDDESYCVAGTILAY.TQ.RNVPLTYVCLTLGEMGRA...MGN...---...
  40 LPCAHEVLAVFAHPDDESFGLGAVLGDF.TA.QGTRLRGLCFTHGEAS--...---...---...
  41 PDDWRRALAVVAHPDDLEYGCSAAVASW.VA.DGKDVAYLLATRGEAG--...---...---...
  42 LPCAHEVLAVFAHPDDESFGLGAVLGDF.TA.QGTRLRGLCFTHGEAS--...---...---...
  43 ----LDLLVVAPHPDDGELGCGGTLARA.KA.EGLSTGILDLTRGEMGSK...---...---...
  44 ------VMTVFAHPDDMEVHCGGTVRKL.SS.AGHRVIEVIMSKGNNG--...---...---...
  45 -LKSMKILVIGAHPDDMEIACGGSLAKL.CD.AGHTIWGLVLSNGEMG--...---...---...
  46 WQDWSSVLIVVAHPDDPEYGLSAAVKEW.TD.AGVEVSYLLLTHGEAG--...---...---...
  47 WQDWSSVLIVVAHPDDPEYGLSAAVKEW.TD.AGVEVSYLLLTHGEAG--...---...---...
  48 -----RILFISPHPDDECDNAGGTLAKL.-A.KSHEIYIVYMTDGSAGSP...---...---...
  49 MWTNKEIMVIVPHQDDEINLAGATIKRL.ID.NGNNVKVVFATNG-----...---...---...
  50 --AGQRVLLLAPHPDDETLCCGGTVQQA.RA.AGAEVFIAWMTAGDGFEFdaaLTE...HVL...
  51 -LAVESILFVFAHPDDESMFFGPTIDYLgNQ.HSTRVHVLCLSNG-----...---...---...
  52 -SCMRRVLIVAPHPDDETLCCGGTIQIF.KE.KGYKISVIIVTDGRYGSP...DDK...LK-...
  53 LKSTVTVMHTGAHPDDEQN---GLLAYFrTE.LGMRTIIACSTRGEGGQN...---...---...
  54 LKSTVTVMHTGAHPDDEQN---GLLAYFrTE.LGMRTIIACSTRGEGGQN...---...---...
  55 LQDARRLVVVAPHPDDEVLGCGGLMAAA.QA.HGIPVCVIALTDGEMAYP...HVP...AW-...
  56 -ISFGRTLVVAPHPDDEVLGAGGTIARL.AA.EGEEVFVAVVTEG-----...---...---...
  57 MTGVTDVLVVAPHPDDDVIGCGGSMAKH.VR.EGARVTVVVV-IGRERSA...LDD...AV-...
  58 -----RIMAVFAHPDDE-IGCIGTLAKH.AR.RGDEVLLVWTTLGELASQ...FGD...T--...
  59 LGTATRVVVVSPHPDDEVLGCGGLLAMA.IA.SGRQALIVSVTDGEAAYP...QDD...AW-...
  60 -----TGLVVSAHSADFVWRAGGAIAAH.AR.QGYAVTVVCLSFGERGE-...-SA...KLW...
  61 DLDADRILAISPHLDDAVLSFGAGLARA.AQ.AGAKVTVHTVFAGTAAPP...YSPaaeRLH...
  62 -LGAGRLLAISPHLDDAVLSFGAGLARA.AQ.DGAKVTVYTVFAGTATPP...YSPaaeRLH...
  63 ----TSVLVVVAHPDDAEIAMGMRIHWY.AL.NGATVRVHCLTTGTPAP-...---...---...
  64 -----KILALGAHPDDIEIFMFGTLAVY.AA.QGAELTFAVATDGAKGGK...SDA...TV-...
  65 ---PLDWLCLAPHPDDAEIGAGGTLIRL.AQ.AGRAVGILELTRGEKGTQ...---...---...
  66 -LLPGRYLLLIAHPDDESMFFAPSLLSL.--.-GGDIDILCLSNG-----...---...---...
  67 --KRKGILAIGAHPDDIELGCGASLARL.AQ.KGIYIAAVVMTTGNSGT-...---...---...
  68 --------VVAPHPDDEALGCGALLAAL.AE.AGREVWALLLTDGGFSHP...ASK...AY-...
  69 PGAGSRALVVIAHPDDEAMFFAPTMLGL.AR.LEQQVSLLCFSSG-----...---...---...
  70 LLSQSRILLLIAHPDDETMFFSPTIRAL.LQ.AGHRVFVLCISNG-----...---...---...
  71 PGRPLELLCLGAHSDDIEIGCGGTLLHL.IE.TGTPLHVEWCVL------...---...---...
  72 -ATARSVLHIIAHQDDDLYFMNPDLIRS.LR.DGDQVTTVVVTAGEGDGV...---...---...
  73 ----------------------------.--.------------------...---...---...
  74 PLCIKGYXSLTPHPDDETLAAGGLIQDT.LK.YGGEVKVVVMTNGDSFKRaviENY...NTI...


               60         70          80            90        100      
               |          |           |             |          |      
   1 QLTAD.....HADQLGGY.RIGELTAALRAL..GVS..APIYLGG..AGR.WRDSGMAG.....T
   2 KPGIL.....D--NIFAV.RQEEMAKAMEIL..GTE..-HRWLG-..---.YEDSGLPQ.....G
   3 QLTAD.....HADQLGGY.RIGELTAALRAL..GVS..APIYLGG..AGR.WRDSGMAG.....T
   4 ELTVD.....HADQLGGY.RIFELTEALRAL..GVS..APIYLGG..AGR.WRDSGMRG.....T
   5 KPGIL.....D--NIFAV.RQEEMAKAMEIL..GTE..-HRWLG-..---.YEDSGLPQ.....G
   6 QGDAY.....IEENIHEV.RRKEMDEAREIL..GVG..-QEWLG-..---.FVDSGLPE.....G
   7 -DLPD.....VHGRIAEI.RRDEMTKAAEIL..GVE..-HTWLG-..---.FVDSGLPK.....G
   8 -DLPD.....VHGHIAEI.RRDEMAKAAEIL..GVE..-HTWLG-..---.FIDSGLPK.....G
   9 GDPGH.....DPAAVALM.RRRELEESRDIL..KIS..DLETLD-..---.YADSGMMG.....W
  10 HLSGA.....---ALGGH.RRGELADAMRAL..GVD..DFRLLGG..PGR.YADSGMLGl....S
  11 -DSSL.....TGHELATI.RRREEEESSKLL..GVK..KIYWLN-..---.YRDTELPY.....S
  12 -DESL.....SGHELAAI.RRKEEEESARLL..GVK..KIYWLN-..---.YRDTELPY.....S
  13 -DEKL.....SGHELALI.RRREEEESAKLL..GVR..KIYWLN-..---.YRDTELPY.....S
  14 -----.....NFEHKAKV.RRQELWRSCSKL..GIP..-------..---.ESNIVLMN.....A
  15 -----.....---GTIEL.RKEEAKAAARIM..GVK..TRLNLA-..---.MPDRGLYM.....K
  16 QLVNG.....DADQLGGF.RIHELYASLEIL..GVR..-GIHLGG..AGC.WRDSGMVG.....D
  17 TVPGM.....TVDDLGAQ.REQELREACRAL..EIE..PPVFLD-..---.YHDSGRYE.....R
  18 KPPIDle7esNFEHKAKV.RRQELWRSCSKL..GIP..-------..---.ESNIVLMN.....A
  19 -PPFA.....TRESLPDI.RKKELIKSAEAM..GIE..DLRMLG-..---.YRDKTIEF.....E
  20 -PFFA.....NRETLPLL.RKQELINACKEM..DIN..DLRMLG-..---.LRDKTLEF.....E
  21 -----.....---GTVEQ.RQKEAADASRIL..GID..ERIQLD-..---.LPDRGLRN.....P
  22 -----.....---GTVSL.RKEEAAEAARIL..GAD..KRIQLT-..---.LPDRGLIM.....S
  23 -HPHL.....KPEEYAKQ.KIEEAKKAAEIL..GAE..-SIFLP-..---.YRDAELPV.....N
  24 -----.....---GTAET.RRQEAALATERM..GYV..AREQLD-..---.LGDSELFY.....T
  25 -----.....---GTAET.RRQEAALATERM..GYV..AREQLD-..---.LGDSELFY.....T
  26 NPTPR.....DFYKLGLA.RQQESIAAMRIL..GLPrkDLIFLG-..---.FADGSTRFlw6ywD
  27 -----.....EGETLGDR.RAVEARAAADVL..GVD..RLEFLG-..---.YTDSGMTA.....A
  28 -TDDF.....TPERFVAV.RSAELDASARNL..GYS..AVHRLG-..---.YRDSGMDG.....T
  29 -----.....NYYNQGET.RKKELLQSCDVL..GIP..-------..---.LSSVMIID.....N
  30 RKGDM.....TEERVKAS.RHTEAQAAANVL..GAS..-IEFFD-..---.MGDYPLRA.....D
  31 RKGDM.....TEERVKAS.RHTEAQAAANVL..GAS..-IEFFD-..---.MGDYPLRA.....D
  32 -TREI.....THDEIVKI.RDAEKRKAGEIL..GVT..EFIDLG-..---.FEDGGNYT.....I
  33 -----.....NYYNQGEI.RKKELLQSCAVL..GIP..-------..---.PSRVMIID.....K
  34 ---CD.....GPEELARM.RAVELAACLEVI..GLT..-------..---.TTPGSLHE.....Q
  35 -PPFA.....TRESLPSI.RERELEEACKVI..GIT..DLRKMG-..---.LRDKTVEF.....E
  36 -IDTL.....APAECAPL.REREQRASAAVV..GVS..EVEFLD-..---.HRDGVVEY.....G
  37 -NVFA.....NRETIPNI.REKELKDACVAM..GIQ..DLRMLG-..---.FHDKTLEF.....E
  38 -----.....NHDRKGAV.RRQELWDACESM..GVR..-------..---.PEDITLVN.....A
  39 -PPFA.....TRESLYAI.REKELKRATNIL..GIK..DLRMMG-..---.YRDKTLEF.....E
  40 -TLGR.....TDRNLGEV.RREELAAAAQVL..GVD..HVQLLA-..---.YPDNGLAQ.....I
  41 -IDTL.....DPGRAGPL.REAEQRAAAAAV..GVR..AVEFLD-..---.HRDGVIEY.....G
  42 -TLGR.....TDRNLGEV.RREELAAAAQVL..GVD..HVQLLA-..---.YPDNGLAQ.....I
  43 -----.....---GTPEE.REKEVAEASRIL..GLD..FRGNLG-..---.FPDGGLAD.....V
  44 -----.....---GDEEV.REREAIEGAKCL..GVD..RVEFLN-..---.HEDGRISV.....D
  45 -----.....---GNSPS.RLREAKKSAEFL..GLS..KLEIRD-..---.FPDTRLDH.....F
  46 -IQGL.....DPKETGSL.RAAEQRAACDVV..GVR..NLTILN-..---.HPDSMLVY.....N
  47 -IQGL.....DPKETGSL.RAAEQRAACDVV..GVR..NLTILN-..---.HPDSMLVY.....N
  48 -NPEE.....RGEKLAEI.RRKEALEGLKVL..GIKkdNAFFLN-..---.YPDTKLRF.....H
  49 -----.....DFKGLGTK.RIKEAVEAVRIL..GVNseNVIFLGY..GDR.WEETKEHI.....Y
  50 VPRPH.....NMRALGQT.RAGEAERAAAVL..GVPadHTFMLG-..---.YPDGGLFRlf...T
  51 -----.....NADGLGSV.REKELVVAASKY..QID..-------..---.KTNVHVVS.....D
  52 -----.....GSSELIEI.RRQEALRATKIL..GID..EVKFLN-..---.FEDSKVSE.....-
  53 ALGPE.....RLGALGVI.RSRELEEAARVI..DAD..-ISWLGHgpADI.IHDFGFSK.....D
  54 ALGPE.....RLGALGVI.RSRELEEAARVI..DAD..-ISWLGHgpADI.IHDFGFSK.....D
  55 -----.....APHLLAPA.RRQELDAALAAL..GLTnhAVTHCD-..---.LGDGALHE.....H
  56 KPPAF.....DPEATARI.-QAEARQAHRAL..GVT..ETIWLR-..---.LPAAQLAE.....T
  57 -----.....----TEAE.FAAETENAAKIL..GVH..RCVRFD-..---.ESSRDFAP.....S
  58 -----.....EHEEVRRI.RREHGAWVADKI..GAK..-YHFFD-..---.MGDSRMTG.....G
  59 -----.....PPARLAAA.RREELRDALARL..GIDpsSIVRLD-..---.AGDGQVRA.....G
  60 KKSGM.....TLETVKAD.RRREAENAAKAL..GVH..DILFYD-..---.LGDYPIQV.....T
  61 AIWEL.....SPDQDASLrRRDEDIAALDHL..GVDyrHGRFLDA..IYRkLPDGRWLA.....D
  62 GIWGL.....SPDQDASLhRRNEDIAALDHL..GVDyrHGRFLDA..IYRtLPDGRWLA.....D
  63 -----.....---DGTEV.RRQECLSAGELL..GVD..QYTFSS-..---.IPDTRFVE.....N
  64 -----.....----LARV.RREEATAAAGLL..GAA..-PRFLD-..---.FPDGELVA.....D
  65 -----.....---GTPAE.RQAECVAAARLM..DLS..WRGQLG-..---.LPDGELAD.....T
  66 -----.....NKEGKGKE.REKELRKVGCYT..GAK..VLITTF-..---.FSDGE---.....-
  67 -----.....---DGIID.RHEESRNALKIL..GCH..QTIHLN-..---.FADTRAHL.....Q
  68 -----.....PRPRLSAV.RLAEWREGLSVL..GVPpaRTVALG-..---.LPDGALGE.....H
  69 -----.....NYYNQGEI.RKKELLQSCAVL..GIP..-------..---.PSRVMIID.....K
  70 -----.....NFDGLGKI.RARELSRAASKL..GISasDVICLD-..YDE.FADGDTWN.....R
  71 -----.....---SGNEQ.RRAEAEASARDFlrGMD..-RFQLHV..AS-.FADSYFPA.....E
  72 -----.....NADTGDPG.RAGET---PDYA..GYS..TERGCG-..---.LRSAYARM.....V
  73 -----.....--------.------------..---..----LG-..---.LRDKTLEF.....E
  74 KPTPH.....DFLRLGYE.RQRETISVLKYL..GVKeeNIIFLG-..---.YPDKGLV-.....-


                    110            120       130               140     
                     |              |         |                 |     
   1 D...QRSQ.....RRFVDAD.....PRQTVGALVAIIRELRPHVV...VTYDPN.....GGY.GH
   2 DplpPLPE.....GCFALED.....SDKVTQDLVKILREFRPHVI...ITYDEN.....GGY.PH
   3 D...QRSQ.....RRFVDAD.....PRQTVGALVAIIRELRPHVV...VTYDPN.....GGY.GH
   4 A...PRRR.....QRFIDAD.....ENEAVGALVAIIRELRPHVV...VTYDPH.....GGY.GH
   5 DplpPLPE.....GCFALED.....SDKVTQDLVKILREFRPHVI...ITYDEN.....GGY.PH
   6 DplpPLPE.....GCFALED.....VDKAAGELVRKIRSFRPQVI...TTYDEN.....GGY.PH
   7 DlppPLPD.....DCFARVP.....LEVSTEALVRVVREFRPHVM...TTYDEN.....GGY.PH
   8 DpppPLPD.....DCFALVP.....LEVCTEALVRVVRKFRPHVL...TTYDEN.....GGY.PH
   9 Ps..NDAP.....GSFWRTP.....VEEGAARLAELMRHYRPDVV...VTYDEN.....GFY.GH
  10 D...NDDP.....GCLWQAD.....VDAAAALLVDVIREVRPQVL...VTYDPN.....GGY.GH
  11 -...----.....-------.....-REVRKDLVRIIRKEKPDGV...FLPDPW.....LPYeAH
  12 -...----.....-------.....-REVRKDLTKILRKEQPDGV...FAPDPW.....LPYeSH
  13 -...----.....-------.....-REVRKDLVKIIRKEKPDGV...FAPDPW.....LPYeSH
  14 T...NLPD.....DPYVDWR.....PDAVASLILHTIESLDIQAI...FTFDRD.....GVS.SH
  15 -...----.....-------.....-EEYIREIVKVIRTYKPKLV...FAPYYE.....--D.RH
  16 P...ANEH.....PRAFIHS.....GDRAVEQLKELLAELKPHLL...ITYGPD.....GGY.GH
  17 Tr..HDDP.....TALMNVN.....PLDAEVKLRALIEDVQPQVI...VTFDPH.....GAY.GH
  18 T...NLPD.....DPYVDWR.....PDAVASLILHTIESLDIQAI...FTFDRD.....GVS.SH
  19 -...----.....------D.....ETKLTDMVSDLMAELNPSLI...ITFYPG.....-YS.VH
  20 D...D---.....-------.....-EYLADIMEEIIDDVKPSLI...VTFYPG.....-HG.VH
  21 S...----.....-------.....-EQQVRNIVSVIRHCQPTFV...FVPYPV.....--D.RH
  22 -...----.....-------.....-DQAIRSIVTVIRICRPKAV...FMPYKK.....--D.RH
  23 -...----.....-------.....-DEVKFKLAEVIREKKPDVI...ITHWKN.....--S.MH
  24 -...----.....-------.....-KESLHKIIRIIRKYRPDTV...FCNPPD.....--E.RH
  25 -...----.....-------.....-KESLHKIIRIIRKYRPDTV...FCNPPD.....--E.RH
  26 N...NRPRv16vyKPRAPYT.....GQTLVDELTEIIKDFKPTDI...YYPLAD.....--D.IH
  27 -...ADGA.....GTFQTAD.....VEEAARKLAAILREERADVL...TVYDEK.....GTY.GD
  28 -...AGGA.....EAFVRAP.....LDEAATRLARVIADERPDVV...IGYGTNh....TRD.PH
  29 R...DFPD.....DPGMQWD.....TEHVARVLLQHIEVNGINLV...VTFDAG.....GVS.GH
  30 -...----.....-------.....-KESLFRLADVFRRIQPHFV...LTHSLA.....DPY.-N
  31 -...----.....-------.....-KESLFRLADVFRRIQPHFV...LTHSLA.....DPY.-N
  32 -...----.....-------.....-DSLIEKLVRTFRTVKPELV...LTVDGW.....APYeAH
  33 R...EFPD.....DPEVQWD.....TEHVASTILQHIHANATDLV...VTFDAE.....GVS.GH
  34 H...QFPD.....KYLKDYP.....FEELVETAREAMERLRPETV...LTFPPN.....GSN.GH
  35 -...----.....------P.....YEHIDGMIKSLIDDTNPSLI...ISFYPG.....-YA.VH
  36 -...----.....-------.....-TALRRDIAAAIRRHRPELV...ITMNHRdtwggVAW.NT
  37 -...----.....------D.....VDFVADKIEAIIQEVNPSRI...ITFYPE.....-HG.VH
  38 T...HLQD.....DPTAEWR.....AVTIANQLLRQLESLDAELL...ITFDKE.....GIS.GH
  39 -...----.....------T.....PGELRRVIQKCVEELNPSLV...ISFYPG.....-YA.VH
  40 -...----.....------P.....LNELTQRVVDALAGA--DLL...LVFDDN.....GVT.GH
  41 -...----.....-------.....-ASLRRDIAAAVRRHRPELV...ITLNHRdtwaaGAW.NT
  42 -...----.....------P.....LNELTQRVVDALAGA--DLL...LVFDDN.....GVT.GH
  43 -...----.....-------.....-PEQRLKLAQALRRLRPRVV...FAPLEA.....--D.RH
  44 -...----.....-------.....-PESIDAVRALISKFEPDVV...FTHSPN.....--D.TH
  45 -...----.....-------.....ILEITKQIEIIVDELKPDVV...FTHSIH.....--D.LH
  46 -...----.....-------.....-LVLRKDIAREIRIRKPNAV...VVSNFDveay.GGL.NQ
  47 -...----.....-------.....-LVLRKDIAREIRIRKPNAV...VVSNFDveay.GGL.NQ
  48 -...----.....-------.....IREASERVAKILREIKPNII...IYPSLL.....--D.GH
  49 N...SDDNk26isGEPSSYT.....RGNYKNDMKDVIEMYFPDII...FAIDF-.....--D.SH
  50 T...NYA-t19alTPGHAFT.....GRNLETDLRRVLDRVQPDVV...LAPAPQ.....--D.FH
  51 P...QLQD.....GMQAKWD.....PTDVAKHISQIIERYNIKTL...ITFDNK.....GIS.GH
  52 -...----.....-------.....-EDAENALAEFLREN--DVV...FSPIPF.....--D.NH
  53 -...--GD.....QTFGRWG.....QNRIVERLVRAYRKERPDIV...IPTFLD.....VPG.QH
  54 -...--GD.....QTFGRWG.....QNRIVERLVRAYRKERPDIV...IPTFLD.....VPG.QH
  55 E...----.....-------.....-DAMTHAIASHLQPQ--DLV...LVTWHR.....--D.AH
  56 A...H---.....-------.....-ATVNAALLELVHRLSPQTV...LLPFVG.....--D.MH
  57 -...----.....-------.....-RRIHLDLVRVLREVRPQVV...YLPHDN.....--D.DD
  58 -...----.....-------.....-RDEALQLARLYATFRPHAV...ITWSDD.....--H.PH
  59 -...----.....-------.....VDALGARLADLLQPR--DVV...LVTYAR.....--D.GH
  60 -...----.....-------.....-PEAFDRLVDLYREIRPEFM...LTHSRQ.....DPY.-N
  61 N...VPGR.....QKLAIGRqs9elFSAVRADIESIVEEYAPALI...LTCAAG.....--N.GH
  62 N...VPGR.....QKLAISRls9dlFAAVRDDIKSVVEECDPTLI...LTCAAG.....--N.GH
  63 R...----.....-------.....-GRINADLFDVFREARPDII...YTHYPD.....--D.QH
  64 -...----.....-------.....-AALIGALKTLIAGTGPDLV...ITHAPN.....--D.YH
  65 -...----.....-------.....-PPFAHALAAALRTVRPRVL...VVPHWH.....--D.RH
  66 -...----.....----DWD.....PVMIYIKLLAIYILRPFDVL...MTFDEA.....GVS.GH
  67 -...----.....-------.....LNDMISALEDIIKNQIPSDVeimRVYTMH.....DAD.RH
  68 -...----.....------L.....TAAARAQVRQAFAQARPGTV...LLPWER.....--D.PH
  69 R...DFPD.....DPEVQWD.....TELVASTLLQHIHANGTDLV...VTFDAE.....GVS.GH
  70 -...----.....-------.....-NALCQIVMRHVEVLAADTV...ISFDSH.....GVS.GH
  71 S...----.....-------.....-RAIKEWLIAQRGRGQPDIV...FTHYHG.....--D.AH
  72 T...GDRDh69tvGEVQHVT.....REQVITGLAALLAHIRPTSV...RTMDPDp10dfVCS.DH
  73 D...D---.....-------.....-EYLADIMEEIIDDVKPSLI...VTFYPG.....-HG.VH
  74 -...----.....-------.....--------------------...------.....---.--


         150           160              170            180       190   
          |             |                |              |         |   
   1 PDHVHTHTVTTAAVA....AAGVGSG....T...ADH...PGDPW..TVPKFYWTVLGLSALISG
   2 PDHLKVHEVSMLAWE....KSGDAAY....A...PE-...LGAPW..EPLKLYYTHGFIRQRMEM
   3 PDHVHTHTVTTAAVA....AAGVGSG....T...ADH...PGDPW..TVPKFYWTVLGLSALISG
   4 PDHVHTHFITAAAVAssgvAAGLEVG....A...DEY...PGKPW..KVPKFYWSVFALSAFEAG
   5 PDHLKVHEVSMLAWE....KSGDAAY....A...PE-...LGAPW..EPLKLYYTHGFIRQRMEM
   6 PDHIMTHKITMVAFE....GAADTEK....Y...PESe..YGTAY..QPLKVYYNQGFNRPRTEA
   7 PDHIRCHQVSVAAYE....AAGDFCR....F...PD-...AGEPW..TVSKLYYVHGFLRERMQM
   8 PDHIRCHQVSVDAYE....AACDYRR....F...PD-...AGKPW..TVSKLYYNHGFLRARMQL
   9 PDHIQAHRITMAALE....MTTLT--....-...---...-----..--PKVYWTTAPRSMMQRF
  10 PDHIQAHRIAMRAAE....LAAEA--....-...---...---GC..PVAKVYWNRVPRSRVEDA
  11 PDHRNTGFLALDAVA....FSPLPNF....SnvdVEI...GLGPH..QVSFIALYYTN-------
  12 PDHRRTGFLAIESVA....FSQLPNF....SntdLDI...GLNPY..NSGSFIALYYT-------
  13 PDHRRTGFLAIESVA....FSQLPNF....SnidIDI...GLKPH..SVSFIALYYTH-------
  14 PNHCAVYYAAASLCL....ANLLPKD....C...KFY...TLDSI..NVVRKYLSILD-------
  15 PDHANCAKLVEEAIF....SAGIRKY....M...PEV...PPHRV..ESFYHYMINGF-------
  16 PDHIRAHEITHAAA-....-------....-...---...-----..GEQRILWAVSDREELEDG
  17 VDHLQMHRATVAAFF....STG----....-...---...HLPSG..GPQRLYYTAMTHQAAAQI
  18 PNHCAVYYAAASLCL....ANLLPKGeeayC...KFY...TLDSI..NVVRKYLSILD-------
  19 PDHEATGRAVVRAVR....RLEKS--....-...---...-----..MRPKLYGVAFSNGHQEEL
  20 PDHDACGEAVIRALY....RKKKE--....-...---...-----..DRPRTICMAITRNREE--
  21 PDHGHCAELVKEAVF....NARIRNY....K...AEG...GAHHV..QDLFYYMINSF-------
  22 PDHGNAAALVEEAIF....SAGIHKY....K...DEK...SLPAH..KVSKVYYYMIN-------
  23 PDHANTYLIVEGALL....IAALP--....-...---...-----..--------AFELKYPAHG
  24 PDHMKASRLIYEACY....YAGLRKI....E...TFD...GGLPQaaHRPRHLLYYIQFKQ----
  25 PDHMKASRLIYEACY....YAGLRKI....E...TFD...GGLPQaaHRPRHLLYYIQFKQ----
  26 PDHWAVSNFVRYTIT....AMNLNVR....E...HMF...LVHHP..QWPVPWMAEKNR------
  27 PDHIQVHRVGTRAAE....LAG----....-...---...-----..-TAKVFQSTINREHIKAN
  28 PDHIRANEVLTRRVD....LLD----....-...---...-----..HTPAVYHIAFS-RRRHRA
  29 SNHIALYAAVRALHS....EGKLPKG....C...SVL...TLQSV..NVLRKYISLLDL------
  30 YDHPLAANLAQEARI....IAQAEGY....R...PG-...-----..------------EAIIGA
  31 YDHPLAANLAQEARI....IAQAEGY....R...PG-...-----..------------EAIIGA
  32 PDHEKTGKGVTAAIL....AAR--NL....S...LPH...LGEPF..SVPQIAFYATP-------
  33 SNHIALYKAVRALHS....GGKLPEG....C...SVL...TLQSV..NVLRKYVFLLDL------
  34 PDHMTTHRAVKAAWD....RLPAG--....-...---...-----..SRPVLWYYASETPPENEE
  35 PDHEATADAVIRTVE....RMPKE--....-...---...-----..ERPRLTLVAFSNDATEAL
  36 PDHVAVGRATLDAAA....DAGNRWI....F...PELtdrGLEPW..NGVRWVAVAGS-------
  37 PDHDAFGRAVVRAVS....RMSTE--....-...---...-----..ERPVIHAVAITKNR----
  38 PNHSAIYYATASLCL....SGMIPNN....C...KVL...TLETV..NLCRKYLSIFDLPA----
  39 PDHDATGEAVAEALA....TIPEN--....-...---...-----..KRPTFYAVAFANNHEAEI
  40 PDHRRATEAALAAAS....TPGIPVL....A...WAL...PQPIA..DRLNAEFSASFGGR----
  41 PDHVAVGRAVLDAAA....DAGNRWI....F...PELaeqGLVPW..NGVRWVAVANS-------
  42 PDHRRATEAALAAAS....TPSIPVL....A...WAL...PQPIA..DRLNAEFSASFGGR----
  43 PDHTAASRLAVAAVH....LAGLR--....K...APL...EGEPF..RVERLFFYPGNHP-----
  44 QDHRRTFRIVTSAVS....KFP----....-...---...-----..------------------
  45 QDHRSVHRATLRACR....NLS----....-...---...-----..------------------
  46 ADHRVAGLAAIDATR....DAANPWA....Q...PEL...LQEDL..QPWGAEVIIIAGHP----
  47 ADHRVAGLAAIDATR....DAANPWA....Q...PEL...LQEDL..QPWGAEVIIIAGHP----
  48 NDHWSGGYITRIAIR....KVGITVN....-...---...-----..ELSYLNWLPIPSKSVFDA
  49 ADHKSTSLIFEEAFC....EVLRENK....E...YN-...----P..KVFKGFAYKTAWKAKDDF
  50 ADHHTLSYIALRLMG....ERQQE--....-...---...-----..DRLRFWVVHGG-------
  51 PNHIACYEGAMKIVK....ATPQV--....-...QVF...VLESV..NIFRKYISYLD-------
  52 PDHANIGKAVEKLY-....-------....-...---...-----..PNAYFYLIWGNT------
  53 GHHRAMTRAAKSAIT....LAADPSA....Y...PEHfseGLKPW..QVAKFYLPAWS------G
  54 GHHRAMTRAAKSAIT....LAADPSA....Y...PEHfseGLKPW..QVAKFYLPAWS------G
  55 PDHEAAARATRAACA....RHGVRLL....T...YPV...WAWHW..SQP---------------
  56 MDHQLTFTSALVACR....PHQAE--....-...---...-----..-FPKLVLAYETLSE----
  57 VEHRMVHRLTTEALW....MAQSE-F....F...QEA...GECPM..PAPRLVLGYEVWSPM---
  58 PDHRMTAKIAFDAVT....LARIPKI....L...NE-...AGTSA..AALSPAPDLGGDAAPESG
  59 PDHEACADAASNAVA....QCGARLI....Q...FPI...WAWHW..DDPDHSQMLAS-------
  60 FDHPMATEFAQHARV....IAQAHGH....K...PS-...-----..------------TPVLGA
  61 VDNEIARDAALFVAY....EKGIRVR....L...WE-...-----..----------------DL
  62 IDNEITRDAALLVAH....EKDLPVR....L...WE-...-----..----------------DL
  63 LDHSVTAREVTTVAR....REAPNLR....H...FR-...-----..------------------
  64 ADHRALSDSVRIAAS....FAV----....-...---...-----..--PVLHADTMGG------
  65 PDHFGTYHLTKRAIH....LAALK--....K...ADL...GGDPW..RVQRVLLYQGN-------
  66 KNHISCSKGAGLFLK....IHSVK--....-...-GL...LLKSK..NLFQKYGVDMSFSRISST
  67 QDHLAVYQASMVACR....TIP----....-...---...-----..------------------
  68 PDHRAAWHLLRGVLP....SDTLALE....Y...AV-...-----..------------------
  69 SNHIALYKAV-----....-------....-...---...-----..------------------
  70 HNH------------....-------....-...---...-----..------------------
  71 QDHRTVNELTWNLFR....DQLILEY....E...IPK...WDGDL..GRPNAYSALPA-------
  72 VDHTVTAEFALAALA....RYREAGH....N...PVV...ECYRA..YANRFWGYNLDSSAVTEK
  73 PDHDACGEAVIRALY....RKKKE--....-...---...-----..DRPRTICMAITRNREE--
  74 ---------------....-------....-...---...-----..------------------


           200       210        220        230            240          
            |         |          |          |              |          
   1 ARALV.PDDLRPEWVLPRADEIAFGY.SDDG.IDAVVEAD.....EQARAAKVAALAAHA.....
   2 FHDLL.IEQGKPSPYTPMLERWKANE.ADVMaRVTTQVPC.....ERFFDQRDDALRAHA.....
   3 ARALV.PDDLRPEWVLPRADEIAFGY.SDDG.IDAVVEAD.....EQARAAKVAALAAHA.....
   4 MNALQ.GKDLRPEWTIPPREEFYFGY.SDKD.IDAVVEAT.....SDVWAAKTAALTAHA.....
   5 FHDLL.IEQGKPSPYTPMLERWKANE.ADVMaRVTTQVPC.....ERFFDQRDDALRAHA.....
   6 LHHAL.LDRGLESPYEDWLKRWSEFE.RKER.TLTTHVPC.....ADFFEIRDKALIAHA.....
   7 LQDEF.ARHGQRGPFEQWLAYWDPDHdFLTS.RVTTRVEC.....SKYFSQRDDALRAHA.....
   8 LHDEF.AKHGQAGPFDKWLAQSNPAH.DPFEsRVTTRVEC.....SAYFSQRDDALRAHA.....
   9 GEIMReFHPDMPEPDPAEAAAMAEIG.LPDE.EITTWVDT.....TSFSGQKFDALAAHA.....
  10 FA-RL.RDDLPGLPFEKAAGVEDVPG.VVDD.ERITTEIRgeg..TAYAAAKAAAMRAHA.....
  11 -----.--------------------.----.KPNYFVDI.....TDVMELKLKAIRTHK.....
  12 -----.--------------------.---H.KPNYIVDI.....TDLMELKLKAIRVHR.....
  13 -----.--------------------.----.KPNYIVDI.....TDLMELKLKAIRAHR.....
  14 -----.-----------------LLC.TCFM.STHWCILN.....WKEAAIVRSAMMEHQ.....
  15 -----.--------------------.---H.KPNFCIDI.....SEYVSQKVEALEAYE.....
  16 LKAIT.--GLPEGWGRGELSAVD---.---S.VDLSVELN.....DEVYATKVESMRAHA.....
  17 SRLGH.DQSLDPLVYGV---------.-SDS.TLAVTMDV.....GAYAENKKAALAAHG.....
  18 -----.-----------------LLC.TCFM.STHWCILN.....WKEAAIVRSAMMEHQ.....
  19 -----.--------------------.---G.DPDILFDI.....SPVAEQKKAAIRAHI.....
  20 -----.--------------------.-VLG.EADVVLDI.....KEVADIKMNALRAHR.....
  21 -----.--------------------.---E.RPDLLVDV.....SHCYEVKQAALNAYK.....
  22 -----.--------------------.-GFH.QPDFVIDI.....SDTIEAKKQSLNAYK.....
  23 VRGLF.YGENWEDPYGF---------.----.EPDVYVDI.....TSTYDVWVEAIKQYEfv6gv
  24 -----.--------------------.---L.EPQIVVDV.....SSTFERSRAGIEAFG.....
  25 -----.--------------------.---L.EPQIVVDV.....SSTFERSRAGIEAFG.....
  26 -----.----------PMLPPVDMKN.SN-T.EWQAFELT.....PKEVNMKQAAIKQYR.....
  27 QRVLA.EQAGVDLPAGPDFGTPE---.---A.ELTCRVDV.....SAYTEYKRKALLAHA.....
  28 LHQAC.VDSGVPSPYEGGLSAPP-GA.FDDE.WITTLVDVtk...GDAVERRLDALRSHV.....
  29 -----.-----------------PLS.LLHT.QDVLFVLN.....SKEVAQAKKAMSCHR.....
  30 PPVYC.FEPHQPEQCGW---------.----.KPDVLLDI.....TSVWEKKYAAIQCMA.....
  31 PPVYC.FEPHQPEQCGW---------.----.KPDVLLDI.....TSVWEKKYAAIQCMA.....
  32 -----.--------------------.----.YPNTYIDI.....TNYWENKIEAIKAHT.....
  33 -----.-----------------PWT.LLSP.QGVLFVLT.....SKEVAQAKKAMSCHR.....
  34 LRAAW.--------------------.---L.PPTVKRDV.....SALVTRKLQAIACHR.....
  35 -----.--------------------.---G.EPDIQNDI.....TDFKELKIKAFEAHA.....
  36 -----.--------------------.---S.SPTHAVDA.....TPGMERAVRSLLEHR.....
  37 -----.-------------------E.AVLG.EPDVVNNI.....SEVFEHKLAALGAHR.....
  38 -----.--------------------.TLLL.STNWVILS.....WKARRAVQNAMRLHN.....
  39 -----.--------------------.---G.PPHVKNEV.....KEYVPKKLEALQAHA.....
  40 -----.--------------------.---G.HGHLDIMI.....EVDRSRQLAAIGCHF.....
  41 -----.--------------------.---P.TPSHAVSA.....EPGFEQGVRSLLRHR.....
  42 -----.--------------------.---G.HGHLDIMI.....EVDRSRQLAAIGCHF.....
  43 -----.--------------------.---F.APSFLVKI.....SAFIDQWEAAVLAYR.....
  44 -EVTV.LMGEGPSTVG----------.---F.QPVVYVDV.....TDVLEKKLEAVRVHR.....
  45 -----.----------TILCYESPST.TQSF.QPNVFIDI.....EPYIDIKIESIREHE.....
  46 -----.--------------------.---E.PTHTMDLA.....KDSVDAGVASLQAHK.....
  47 -----.--------------------.---E.PTHTMDLA.....KDSVDAGVASLQAHK.....
  48 IKYLL.IP------------------.---F.HRKIKVDI.....REYKRIKLEAMKKHE.....
  49 YGFNL.ESTLIPEKDSLINKNYDLDV.PQYL.WSERVRLPva8syTQNSNLVNKSLKAHK.....
  50 -----.VEWPLPKGLHPTLGLTLPPR.AARL.PWQKVALT.....PEQEQVKLSAVNTYQ.....
  51 -----.---TIPTLVQSQAGRND---.----.TIIIHADR.....KSTQRIRDAMVRGHK.....
  52 -----.--------------------.-QVN.WREVKFDI.....RKYKESKLRAINQYI.....
  53 GGDTY.DDEIPPPETTLTVNALGKEQ.ATGA.QYDRIGEW.....SRYYH---------A.....
  54 GGDTY.DDEIPPPETTLTVNALGKEQ.ATGA.QYDRIGEW.....SRYYH---------A.....
  55 -----.----------------GDGV.FEDD.RALRFELT.....PAVHAAKQRAITCFS.....
  56 -----.------------TNWNAPYL.SPAF.VPNVFVDI.....SEHLEAKLKAMELFA.....
  57 -----.--------------------.---A.RYQYAEDI.....GEHIHTKVEAMRAYV.....
  58 EDIRR.LAAWRDPIRFY-----QYYA.PASP.YPEVFVDT.....TDTVDVAAEVMAFYQ.....
  59 -----.--------------------.----.-ATRLVLS.....ADAYAAKMQAMSAFK.....
  60 PPVYL.FEPHQPEQCNW---------.----.KPNFLLDI.....TDVWEKKLAAIKCME.....
  61 PHAMF.AEGAAELPDGFRLGPPDFGS.VE--.--------.....PEARARKFEALRLYS.....
  62 PHAMF.GAGPAELPEGFDLGTGDFGS.VT--.--------.....TDMRDRKFEALRLYP.....
  63 -----.----------------SPYS.VGFE.PNEFFFGT.....AELLEAKVRALKCFA.....
  64 -----.--------------------.-TGF.SPTHYVDI.....SAHAEIKAKAIRMHQ.....
  65 -----.--------------------.-SDI.SANVLVDI.....GSVMTEWEAAIRAHT.....
  66 VPFSM.YMEP----------------.----.--------.....-------VKMMCFHR.....
  67 -----.----------QILGYETPST.WLSF.MPQVFESVk....EEYFTVKLAALKKHK.....
  68 -----.--------WLPERGADADWP.RPDE.VEELTFAV.....GDWRDAKARAIASHR.....
  69 -----.--------------------.----.--------.....---------------.....
  70 -----.--------------------.----.--------.....---------------.....
  71 -----.--------------------.----.--------.....---------------.....
  72 AEYLA.--------------------.----.--------.....---------------.....
  73 -----.--------------------.-VLG.EADVVLDI.....KEVADIKMNALRAHR.....
  74 -----.--------------------.----.--------.....---------------.....


             250            260            270       280       290     
              |              |              |         |         |     
   1 TQV.....VV.....GPTGRAAALSNNLA.....LPILADEHYVLAGGSAGARDERGWETDLLAG
   2 TQI.....--.....DPAGAFFGTPVEVQ.....RRLWPTEEFELAKTRV---KTSIPEDDLFAG
   3 TQV.....VV.....GPTGRAAALSNNLA.....LPILADEHYVLAGGSAGARDERGWETDLLAG
   4 TQV.....VV.....GPTGRACALSNNMV.....MPIFAQEHYVLAAGSAGNRDERGWETDLLAG
   5 TQI.....--.....DPAGAFFGTPVEVQ.....RRLWPTEEFELAKTRV---KTSIPEDDLFAG
   6 TQI.....--.....DPEGGWFRVPMEIQ.....KEVWPTEEYELAKSLV---ETSLPEDDLFAG
   7 TQI.....--.....DPNAEFFAAPLAWQ.....ERLWPTEEFELARSRI---PARPPETELFAG
   8 TQI.....--.....DPKAEFFAAPISWQ.....QRLWPTEEFELARSRV---PTRLPEHDLFAG
   9 SQ-.....--.....GENIFFLGMGKERF.....GELMGMETFVRVRDTT---GAAVPENDLFAG
  10 TQI.....--.....TVAEPYFVLSNDLA.....QPILTTEYYELVRGER---GGEGRENDLFAG
  11 SQFpd6weVW.....EPFLRTVALFYGKK.....AGVKYAEGFRIMPGL----------------
  12 SQFpd6weKW.....EPFLRTIAMFYGEK.....IGVRYGEGFRIMPGL----------------
  13 SQFtd6weTW.....EPFLRTVTMFYGEK.....IGVRYGEGFRVMPGL----------------
  14 SQM.....RW.....FRWLYIYF------.....-------------------------------
  15 SQF.....ST.....GSDGVKTPLTEGYVet6arEKMFGKEVGVLYAEGFMSKKPVLLHADLIGG
  16 TQL.....WIa18tqQDNVKVWALSNLIA.....QPIMRHEHYQLGAGTPLPEGATGVL------
  17 TQM.....--.....GETSLMGRLSPDERaale.ERMLGKESFSIGGTRTAIRE--YPLRGLFDG
  18 SQM.....RW.....FRWLYIYF------.....-------------------------------
  19 SQT.....AW.....M-------------.....-------------------------------
  20 TQTe....GM.....LRELEEKLKNNEPV.....MATWFEEEIY---------------------
  21 SQF.....TK.....SKASVDTPLTNGYL.....EAVEARERLYGKEAGAMY-------------
  22 SQF.....IP.....SKDSVSTPLTNGYI.....EIVEAREKLYGKEAGVEYAEVSF--------
  23 STF.....RY.....LDYYTHLAVVRGCL.....MGVKYAQAFMMPEGANKRRGASLPG------
  24 TQF.....HR.....KENSDEPVTMINRK.....EFLPGLE------------------------
  25 TQF.....HR.....KENSDEPVTMINRK.....EFLPGLE------------------------
  26 TQT.....EV.....MEPFLMGFVRKTEL.....FATKPVISIPVVSSKPDLRDADLPH------
  27 SQI.....-T.....PQSTLFTDLPEDTF.....RTMFGTEWFIRAGQGPGITET----------
  28 TQV.....--.....PPASGWFALSPQQL.....RDAFPYEEYTRVG------------------
  29 SQL.....LW.....FRRLYIIF------.....-------------------------------
  30 GQE.....HL.....WEYYTRVALQRGVQ.....A------------------------------
  31 GQE.....HL.....WEYYTRVALQRGVQ.....A------------------------------
  32 SQF.....-D.....NPNWPFIYEFFYEQ.....AKEWYKEGLVK--------------------
  33 SQL.....LW.....FRHLYTV-------.....-------------------------------
  34 SQA.....--.....LSTVDFIRKFPERV.....TSETFYEVPES--------------------
  35 SQT.....GP.....FLKQLASPEIDGKQ.....HSFLTVEPY----------------------
  36 TYI.....--.....---EVLTEEDPETY.....VRGFLTGFAEAAGERFGGRPAV---------
  37 SQT.....--.....--------------.....-------------------------------
  38 SQM.....VW.....FRKLYIIF------.....-------------------------------
  39 SQF.....AT.....--------------.....-------------------------------
  40 TQS.....AD.....NPVLWRRLEL----.....-------------------------------
  41 TYL.....--.....---EALTAEDPETY.....ARRFLGESTGVHRARFDGAPA----------
  42 TQS.....AD.....NPVLWRRLEL----.....-------------------------------
  43 SQF.....--.....--------------.....-------------------------------
  44 SQVerga.IS.....EEMVMKTAEFRGME.....IGVKYAEAFE---------------------
  45 DQNkkry.VQ.....PEQVYGNAIFRGAQ.....AKLKQAEGFEA--------------------
  46 ---.....--.....--------------.....-------------------------------
  47 ---.....--.....--------------.....-------------------------------
  48 SQF.....KY.....LDADY---------.....-------------------------------
  49 TQK.....A-.....--------------.....-------------------------------
  50 TQTr....VM.....GRFMRAFVRENELL.....SPAPLPEHPTPAEETTPP-GEVGPEDSGF--
  51 SQM.....VW.....FRYGWIY-------.....-------------------------------
  52 SQI.....GG.....LPLER---------.....-------------------------------
  53 S--.....--.....--------------.....-------------------------------
  54 S--.....--.....--------------.....-------------------------------
  55 TQL.....--.....---GTCTP------.....-------------------------------
  56 SQV.....RQ.....PPHERSIP------.....-------------------------------
  57 SQL.....--.....--------------.....-------------------------------
  58 ---.....--.....--------------.....-------------------------------
  59 TQT.....GH.....LTPALRNPILPDWA.....LARFQRD------------------------
  60 GQE.....HL.....WEYYTRVALQRGVQ.....-------------------------------
  61 SQM.....LM.....L-------------.....-------------------------------
  62 SQM.....LM.....--------------.....-------------------------------
  63 SQT.....--.....--------------.....-------------------------------
  64 SQD.....--.....----------PDRF.....VDIARTQN-----------------------
  65 SQFag...--.....--------------.....-------------------------------
  66 SQM.....VW.....FRYLYVL-------.....-------------------------------
  67 ---.....--.....--------------.....-------------------------------
  68 TQLg....--.....--------------.....-------------------------------
  69 ---.....--.....--------------.....-------------------------------
  70 ---.....--.....--------------.....-------------------------------
  71 ---.....--.....--------------.....-------------------------------
  72 ---.....--.....--------------.....-------------------------------
  73 TQTe....GM.....LRELEEKLKNNEPV.....MATWFEEEIY---------------------
  74 ---.....--.....--------------.....-------------------------------


        300   
         |   
   1 LGFTASGT
   2 ITPD----
   3 LGFTASG-
   4 LCLD----
   5 ITPD----
   6 I-------
   7 I-------
   8 I-------
   9 --------
  10 IA------
  11 --------
  12 --------
  13 --------
  14 --------
  15 --------
  16 --------
  17 VGV-----
  18 --------
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