(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0168 Glutaminase, B. subtilis
    • gi|6980954|ref|NP_036701.1|_218:535 (NM_012569) glutaminase [Rattus norvegicus]
    • gi|121447sp|P13264|GLSK_RAT Glutaminase, kidney isoform, mitochondrial precursor (GLS) (L-glutamine amidohydrolase) (K-glutaminase)
    • gi|204412|gb|AAA41247.1| (M65150) glutaminase [Rattus norvegicus]
    • gi|21361452|ref|NP_055720.2|_213:530 (NM_014905) glutaminase C [Homo sapiens]
    • gi|12044394|gb|AAG47842.1|AF327434_1 (AF327434) glutaminase [Homo sapiens]
    • gi|14737370|ref|XP_032466.1|_213:530 (XM_032466) glutaminase C [Homo sapiens]
    • gi|12643334sp|O94925|GLSK_HUMAN Glutaminase, kidney isoform, mitochondrial precursor (GLS) (L-glutamine amidohydrolase) (K-glutaminase)
    • gi|4240165|dbj|BAA74861.1| (AB020645) KIAA0838 protein [Homo sapiens]
    • gi|6969579|gb|AAF33825.1|AF223943_1 (AF223943) glutaminase kidney isoform [Homo sapiens]
    • gi|5690372|gb|AAD47056.1|_213:530 (AF158555) glutaminase C [Homo sapiens]
    • gi|6002671|gb|AAF00088.1|_142:459 (AF097492) glutaminase isoform C [Homo sapiens]
    • gi|19919838|gb|AAM08402.1|AF490841_1_46:363 (AF490841) glutaminase [Sus scrofa]
    • gi|21627340|gb|AAM68648.1|_202:523 (AE003821) CG8772-PF [Drosophila melanogaster]
    • gi|21627338|gb|AAM68646.1|_144:465 (AE003821) CG8772-PC [Drosophila melanogaster]
    • gi|21627334|gb|AAM68643.1|_192:513 (AE003821) CG8772-PA [Drosophila melanogaster]
    • gi|19922128|ref|NP_610809.1|_202:523 (NM_136965) nemy gene product [Drosophila melanogaster]
    • gi|15291465|gb|AAK93001.1| (AY051577) GH22838p [Drosophila melanogaster]
    • gi|21627335|gb|AAM68644.1| (AE003821) CG8772-PD [Drosophila melanogaster]
    • gi|21627339|gb|AAM68647.1|_223:544 (AE003821) CG8772-PB [Drosophila melanogaster]
    • gi|21627337|gb|AAM68645.1|_134:455 (AE003821) CG8772-PE [Drosophila melanogaster]
    • gi|21627336|gb|AAF58472.3|_202:523 (AE003821) CG8772-PG [Drosophila melanogaster]
    • gi|20336214|ref|NP_037399.2|_146:463 (NM_013267) glutaminase GA, isoform a; breast cell glutaminase; phosphate-dependent glutaminase; glutaminase I; L-glutaminase; L-glutamine amidohydrolase; phosphate-activated glutaminase [Homo sapiens]
    • gi|6969581|gb|AAF33826.1|AF223944_1_146:463 (AF223944) glutaminase liver isoform [Homo sapiens]
    • gi|20302004|ref|NP_620259.1|_79:396 (NM_138904) liver mitochondrial glutaminase [Rattus norvegicus]
    • gi|1346147sp|P28492|GLSL_RAT Glutaminase, liver isoform, mitochondrial precursor (GLS) (L-glutamine amidohydrolase) (L-glutaminase)
    • gi|1196814|gb|AAC37707.1| (J05499) L-glutamine amidohydrolase [Rattus norvegicus]
    • gi|12643336sp|Q9UI32|GLSL_HUMAN_146:463 Glutaminase, liver isoform, mitochondrial precursor (GLS) (L-glutamine amidohydrolase) (L-glutaminase)
    • gi|6650606|gb|AAF21933.1|AF110330_1 (AF110330) glutaminase [Homo sapiens]
    • gi|21295227|gb|EAA07372.1|_110:430 (AAAB01008851) agCP10153 [Anopheles gambiae str. PEST]
    • gi|17531711|ref|NP_497055.1|_181:503 (NM_064654) Ank repeat [Caenorhabditis elegans]
    • gi|14530339|emb|CAC42253.1| (Z81465) contains similarity to Pfam domain: PF00023 (Ank repeat), Score=26.8, E-value=0.00016, N=1~cDNA EST yk422f8.5 comes from this gene~cDNA EST yk422f8.3 comes from this gene [Caenorhabditis elegans]
    • gi|17531709|ref|NP_497054.1|_181:503 (NM_064653) Ank repeat [Caenorhabditis elegans]
    • gi|14530338|emb|CAC42252.1| (Z81465) contains similarity to Pfam domain: PF00023 (Ank repeat), Score=26.8, E-value=0.00016, N=1~cDNA EST yk57f9.5 comes from this gene~cDNA EST yk129b7.3 comes from this gene~cDNA EST yk129b7.5 comes from this gene~cDNA EST yk297a11.3 comes from th>
    • gi|17532727|ref|NP_495675.1|_142:458 (NM_063274) glutaminase [Caenorhabditis elegans]
    • gi|20141425sp|Q19013|GLS1_CAEEL Putative glutaminase DH11.1 (GLS) (L-glutamine amidohydrolase)
    • gi|15718115|emb|CAA88938.2| (Z49126) contains similarity to Pfam domain: PF00023 (Ank repeat), Score=22.8, E-value=0.0026, N=1~cDNA EST yk1c5.5 comes from this gene~cDNA EST yk596e7.3 comes from this gene~cDNA EST yk596e7.5 comes from this gene~cDNA EST EMBL:AU113591 comes from t>
    • gi|17507019|ref|NP_492162.1|_144:460 (NM_059761) glutaminase [Caenorhabditis elegans]
    • gi|21431781sp|Q93650|GLS2_CAEEL Putative glutaminase F30F8.2 (GLS) (L-glutamine amidohydrolase)
    • gi|15718153|emb|CAC70084.1| (Z79752) Similarity to Rat glutaminase (SW:GLSK_RAT) [Caenorhabditis elegans]
    • gi|15718162|emb|CAB03030.2| (Z81073) Similarity to Rat glutaminase (SW:GLSK_RAT) [Caenorhabditis elegans]
    • gi|21401033|ref|NP_657018.1|_9:326 (NC_003995) hypothetical protein predicted by GeneMark [Bacillus anthracis A2012] [Bacillus anthracis str. A2012]
    • gi|17230426|ref|NP_486974.1|_12:317 (NC_003272) putative glutaminase [Nostoc sp. PCC 7120]
    • gi|17132028|dbj|BAB74633.1| (AP003591) ORF_ID:all2934~putative glutaminase [Nostoc sp. PCC 7120]
    • gi|15615280|ref|NP_243583.1|_6:324 (NC_002570) glutaminase [Bacillus halodurans]
    • gi|12585238sp|Q9K9D1|GLS2_BACHD Probable glutaminase BH2717
    • gi|10175338|dbj|BAB06436.1| (AP001516) glutaminase [Bacillus halodurans]
    • gi|15801612|ref|NP_287629.1|_10:308 (NC_002655) putative glutaminase [Escherichia coli O157:H7 EDL933]
    • gi|15831385|ref|NP_310158.1| (NC_002695) putative glutaminase [Escherichia coli O157:H7]
    • gi|16129483|ref|NP_416041.1| (NC_000913) putative glutaminase [Escherichia coli K12]
    • gi|2494799sp|P77470|GLS2_ECOLI Probable glutaminase yneH
    • gi|7430241|pir||G64906 glutaminase homolog yneH - Escherichia coli
    • gi|1742497|dbj|BAA15206.1| (D90795) Glutaminase, kidney isoform precursor (EC 3.5.1.2) (GLS). [Escherichia coli]
    • gi|1742506|dbj|BAA15214.1| (D90796) Glutaminase, kidney isoform precursor (EC 3.5.1.2) (GLS). [Escherichia coli]
    • gi|1787804|gb|AAC74597.1| (AE000250) putative glutaminase [Escherichia coli K12]
    • gi|12515138|gb|AAG56241.1|AE005352_7 (AE005352) putative glutaminase [Escherichia coli O157:H7 EDL933]
    • gi|13361597|dbj|BAB35554.1| (AP002557) putative glutaminase [Escherichia coli O157:H7]
    • gi|16121252|ref|NP_404565.1|_11:308 (NC_003143) putative glutaminase [Yersinia pestis]
    • gi|15979018|emb|CAC89792.1| (AJ414145) putative glutaminase [Yersinia pestis]
    • gi|21960280|gb|AAM86886.1|AE013935_3 (AE013935) putative glutaminase [Yersinia pestis KIM]
    • gi|15965539|ref|NP_385892.1|_15:313 (NC_003047) PROBABLE GLUTAMINASE A PROTEIN [Sinorhizobium meliloti]
    • gi|21362573sp|Q92PH0|GLSA_RHIME Glutaminase
    • gi|15074720|emb|CAC46365.1| (AL591788) PROBABLE GLUTAMINASE A PROTEIN [Sinorhizobium meliloti]
    • gi|16764870|ref|NP_460485.1|_10:308 (NC_003197) putative glutaminase [Salmonella typhimurium LT2]
    • gi|16420046|gb|AAL20444.1| (AE008766) putative glutaminase [Salmonella typhimurium LT2]
    • gi|15889160|ref|NP_354841.1|_11:307 (NC_003062) AGR_C_3412p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17935749|ref|NP_532539.1| (NC_003304) glutaminase A [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15156974|gb|AAK87626.1| (AE008105) AGR_C_3412p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17740305|gb|AAL42855.1| (AE009140) glutaminase A [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|18310977|ref|NP_562911.1|_7:305 (NC_003366) probable glutaminase [Clostridium perfringens]
    • gi|18145659|dbj|BAB81701.1| (AP003192) probable glutaminase [Clostridium perfringens str. 13]
    • gi|15640481|ref|NP_230108.1|_19:316 (NC_002505) glutaminase family protein [Vibrio cholerae]
    • gi|12585240sp|Q9KUR1|GLSA_VIBCH Probable glutaminase VC0454
    • gi|11278903|pir||F82320 glutaminase family protein VC0454 [imported] - Vibrio cholerae (group O1 strain N16961)
    • gi|9654879|gb|AAF93627.1| (AE004132) glutaminase family protein [Vibrio cholerae]
    • gi|19704729|ref|NP_604291.1|_7:304 (NC_003454) Glutaminase [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
    • gi|19715049|gb|AAL95590.1| (AE010644) Glutaminase [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
    • gi|16128469|ref|NP_415018.1|_5:308 (NC_000913) putative glutaminase [Escherichia coli K12]
    • gi|2494798sp|P77454|GLS1_ECOLI Probable glutaminase ybaS
    • gi|7430242|pir||D64779 probable membrane protein ybaS - Escherichia coli
    • gi|1773167|gb|AAB40239.1| (U82664) similar to rat mitochondrial glutaminase [Escherichia coli]
    • gi|1786693|gb|AAC73587.1| (AE000155) putative glutaminase [Escherichia coli K12]
    • gi|17549364|ref|NP_522704.1|_9:304 (NC_003296) PROBABLE GLUTAMINASE A PROTEIN [Ralstonia solanacearum]
    • gi|17431617|emb|CAD18294.1| (AL646083) PROBABLE GLUTAMINASE A PROTEIN [Ralstonia solanacearum]
    • gi|15800214|ref|NP_286226.1|_5:308 (NC_002655) putative glutaminase [Escherichia coli O157:H7 EDL933]
    • gi|15829792|ref|NP_308565.1| (NC_002695) putative glutaminase [Escherichia coli O157:H7]
    • gi|12513361|gb|AAG54834.1|AE005228_1 (AE005228) putative glutaminase [Escherichia coli O157:H7 EDL933]
    • gi|13359996|dbj|BAB33961.1| (AP002552) putative glutaminase [Escherichia coli O157:H7]
    • gi|21325253|dbj|BAB99875.1|_133:435 (AP005281) Glutaminase [Corynebacterium glutamicum ATCC 13032]
    • gi|18309573|ref|NP_561507.1|_8:306 (NC_003366) glutaminase [Clostridium perfringens]
    • gi|18144250|dbj|BAB80297.1| (AP003187) glutaminase [Clostridium perfringens str. 13]
    • gi|19553680|ref|NP_601682.1|_5:305 (NC_003450) COG2066:Glutaminase [Corynebacterium glutamicum]
    • gi|15596835|ref|NP_250329.1|_7:302 (NC_002516) conserved hypothetical protein [Pseudomonas aeruginosa]
    • gi|12585236sp|Q9I387|GLSA_PSEAE Probable glutaminase PA1638
    • gi|11347814|pir||E83441 conserved hypothetical protein PA1638 [imported] - Pseudomonas aeruginosa (strain PAO1)
    • gi|9947606|gb|AAG05027.1|AE004591_7 (AE004591) conserved hypothetical protein [Pseudomonas aeruginosa]
    • gi|16078547|ref|NP_389366.1|_10:309 (NC_000964) similar to glutaminase [Bacillus subtilis]
    • gi|2494800sp|O07637|GLS1_BACSU Probable glutaminase ylaM
    • gi|7430239|pir||C69873 glutaminase homolog ylaM - Bacillus subtilis
    • gi|2224772|emb|CAB09718.1| (Z97025) putative glutaminase [Bacillus subtilis]
    • gi|2633854|emb|CAB13356.1| (Z99111) similar to glutaminase [Bacillus subtilis]
    • gi|20070082|gb|AAM00020.1|_2:237 (AY083459) kidney-type glutaminase GAC isoform [Rattus norvegicus]
    • gi|15615190|ref|NP_243493.1|_8:308 (NC_002570) glutaminase [Bacillus halodurans]
    • gi|12585239sp|Q9K9L8|GLS1_BACHD Probable glutaminase BH2627
    • gi|10175248|dbj|BAB06346.1| (AP001516) glutaminase [Bacillus halodurans]
    • gi|21225332|ref|NP_631111.1|_12:307 (NC_003888) putative glutaminase [Streptomyces coelicolor A3(2)]
    • gi|12585234sp|P57755|GLSA_STRCO Probable glutaminase SCO7049
    • gi|9716156|emb|CAC01547.1| (AL391039) putative glutaminase [Streptomyces coelicolor A3(2)]
    • gi|16122185|ref|NP_405498.1|_22:331 (NC_003143) putative glutaminase [Yersinia pestis]
    • gi|12585247sp|Q9ZC49|GLSA_YERPE Probable glutaminase
    • gi|11278904|pir||T47019 hypothetical protein [imported] - Yersinia pestis
    • gi|4106607|emb|CAA21362.1| (AL031866) ORF39, len=340 aa, similar to putative glutaminase, from ECAE000155_1 Escherichia coli K-12 MG1655 (310 aa), 42.5% identity in 306 aa overlap, Fasta scores: opt: 846, E(): 0 [Yersinia pestis]
    • gi|15979956|emb|CAC90754.1| (AJ414150) putative glutaminase [Yersinia pestis]
    • gi|21959229|gb|AAM85930.1|AE013840_2 (AE013840) putative glutaminase [Yersinia pestis KIM]
    • gi|16124531|ref|NP_419095.1|_12:304 (NC_002696) glutaminase A [Caulobacter crescentus CB15]
    • gi|13421413|gb|AAK22263.1| (AE005701) glutaminase A [Caulobacter crescentus CB15]
    • gi|10444080|gb|AAG17700.1|_2:242 (AF279697) glutaminase [Homo sapiens]
    • gi|17232266|ref|NP_488814.1|_4:298 (NC_003272) putative glutaminase [Nostoc sp. PCC 7120]
    • gi|17133911|dbj|BAB76473.1| (AP003597) ORF_ID:all4774~putative glutaminase [Nostoc sp. PCC 7120]
    • gi|20846625|ref|XP_129846.1|_1:198 (XM_129846) similar to Glutaminase, kidney isoform, mitochondrial precursor (GLS) (L-glutamine amidohydrolase) (K-glutaminase) [Mus musculus]
    • gi|16330559|ref|NP_441287.1|_22:323 (NC_000911) unknown protein [Synechocystis sp. PCC 6803]
    • gi|2494801sp|P73903|GLSA_SYNY3 Probable glutaminase slr2079
    • gi|7430243|pir||S75105 hypothetical protein slr2079 - Synechocystis sp. (strain PCC 6803)
    • gi|1653050|dbj|BAA17967.1| (D90910) ORF_ID:slr2079~unknown protein [Synechocystis sp. PCC 6803]
    • gi|6002673|gb|AAF00089.1|_8:191 (AF097493) glutaminase kidney isoform [Homo sapiens]
    • gi|204362|gb|AAA41234.1|_5:187 (M22586) pot. glutaminase (EC 3.5.1.2); putative [Rattus norvegicus]
    • gi|21398445|ref|NP_654430.1|_2:220 (NC_003995) hypothetical protein predicted by GeneMark [Bacillus anthracis A2012] [Bacillus anthracis str. A2012]
    • gi|17531711|ref|NP_497055.1|_813:1003 (NM_064654) Ank repeat [Caenorhabditis elegans]
    • gi|14530339|emb|CAC42253.1| (Z81465) contains similarity to Pfam domain: PF00023 (Ank repeat), Score=26.8, E-value=0.00016, N=1~cDNA EST yk422f8.5 comes from this gene~cDNA EST yk422f8.3 comes from this gene [Caenorhabditis elegans]
    • gi|17531709|ref|NP_497054.1|_813:1003 (NM_064653) Ank repeat [Caenorhabditis elegans]
    • gi|14530338|emb|CAC42252.1| (Z81465) contains similarity to Pfam domain: PF00023 (Ank repeat), Score=26.8, E-value=0.00016, N=1~cDNA EST yk57f9.5 comes from this gene~cDNA EST yk129b7.3 comes from this gene~cDNA EST yk129b7.5 comes from this gene~cDNA EST yk297a11.3 comes from th>
    • gi|12007301|gb|AAG45120.1|AF310889_1_930:1185 (AF310889) unknown [Dictyostelium discoideum]
    • gi|6650608|gb|AAF21934.1|AF110331_1_4:124 (AF110331) glutaminase [Homo sapiens]
    • gi|10444082|gb|AAG17701.1|_1:134 (AF279698) glutaminase [Homo sapiens]
    • gi|17989253|ref|NP_541886.1|_22:163 (NC_003318) GLUTAMINASE [Brucella melitensis]
    • gi|17985114|gb|AAL54150.1| (AE009724) GLUTAMINASE [Brucella melitensis]
    • gi|17989252|ref|NP_541885.1|_3:123 (NC_003318) GLUTAMINASE [Brucella melitensis]
    • gi|17985113|gb|AAL54149.1| (AE009724) GLUTAMINASE [Brucella melitensis]
    • gi|20867704|ref|XP_125928.1|_146:257 (XM_125928) similar to glutaminase liver isoform [Mus musculus]
              10        20        30        40        50         60    
              |         |         |         |         |          |    
   1 MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKVNDSQLGICVLEP.DGTMIHAG
   2 QAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTV.DGQRHSIG
   3 QAFRRKLVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTV.DGQRHSTG
   4 QAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTV.DGQRHSTG
   5 QAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTA.DGQRHSTG
   6 QAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTA.DGQRHSTG
   7 QAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTV.DGQRHSIG
   8 QAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTV.DGQRHSIG
   9 KAFRQQFVIPDFTSFVKDIEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSICTI.DGQRFSIG
  10 KAFRQQFVIPDFTSFVKDIEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSICTI.DGQRFSIG
  11 KAFRQQFVIPDFTSFVKDIEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSICTI.DGQRFSIG
  12 KAFRQQFVIPDFTSFVKDIEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSICTI.DGQRFSIG
  13 KAFRQQFVIPDFTSFVKDIEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSICTI.DGQRFSIG
  14 KAFRQQFVIPDFTSFVKDIEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSICTI.DGQRFSIG
  15 KAFRQQFVIPDFTSFVKDIEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSICTI.DGQRFSIG
  16 QAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTV.DGQRHSVG
  17 QAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTV.DGQRHSVG
  18 QAFRKKFVIPDFEEFTGHVDRIFEDAKELTGGKVAAYIPHLAKSNPDLWGVSLCTV.DGQRHSVG
  19 QAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTV.DGQRHSVG
  20 -AFRHQFVIPDFQGFTKDIEEIYWKCKSNADGKVANYIPQLSRVNPDYWGVSVCTI.DGQRFSIG
  21 --LRNQLIIPSWLEFTQLIETIFETCRESKEGEVASYIPQLARQSPHLWGMSICTI.DGQRFSLG
  22 --LRNQLIIPSWLEFTQLIETIFETCRESKEGEVASYIPQLARQSPHLWGMSICTI.DGQRFSLG
  23 --LRNQLIIPSWLEFTQLIETIFETCRESKEGEVASYIPQLARQSPHLWGMSICTI.DGQRFSLG
  24 --LQTDMVIPNWVTFVDQIRTLFNECKEIREGQVATYIPQLARQSPNLWAVSLCTV.DGQRASFG
  25 --LQTDMVIPNWVTFVDQIRTLFNECKEIREGQVATYIPQLARQSPNLWAVSLCTV.DGQRASFG
  26 -ALKKQMIIPDWERFVSDMGEIFEDVRSHNEGDLATYIPQLSRVAPDSWAMSVCTI.DGQRKMWG
  27 -ALKKQMIIPDWERFVSDMGEIFEDVRSHNEGDLATYIPQLSRVAPDSWAMSVCTI.DGQRKMWG
  28 ----IKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKVNDSQLGICVLEP.DGTMIHAG
  29 ---------VEGQEKVCLDQWVAHYRTYAAKGRSASYIPALGEINVSQLGICIVKP.DGTMIKSG
  30 ---------IRPSPLLKVINDLHSKYKSLKEGIVANYIPELAKVNPDLFSISIVTV.DGQVYQVG
  31 ----QSLLEHKPVLSKELEKLVNHYRTLSLNGQCAQYIPALREANQTYLGLYVVHS.NGIEIKSG
  32 -----------------LENILRQVRPLIGQGKVADYIPALATVDGSRLGIAICTV.DGQLFQAG
  33 ------------------NDILQQVRPLIGQGKVADYIPALAEVPANKLGIAVCTL.DGQIFQAG
  34 -------------------SIYTDILPRIGEGKVADYIPELAKIDPRQFGMAIVTV.DGQVFRVG
  35 ------------------DDIYRELTPRLGEGKVADYIPQLARVDARHFGMAIVTT.GGEVYRVG
  36 -----------------LETILQRVRPLIGQGKVADYIPALASVEGSKLGIAICTV.DGQHYQAG
  37 --------------------IYDSMLPRLGEGKVADYIPELAKVDPNQFGIAITTV.DGTTYTAG
  38 -------------------SLIENNRQYVEHGKLASYIPELEKANKEDLGIYIVTL.DGKEVGAG
  39 -------------------EVAAEMAERTDRGDVATYIPQLGKVDPRKFGIAAVTN.DGRVLVAG
  40 ------------------ASIIEEVRPLTSKGIVADYIPALAKVPSDKLGIAVFTN.QGEVITAG
  41 -------------------ELVEKNRKFTADGNVANYIPELDKADKNALGIYVTTL.DGQEFFAG
  42 ------------NKLQQAVDQAYTQFHSLNGGQNADYIPFLANVPGQLAAVAIVTC.DGNVYSAG
  43 -------------------TIHRDIQPWLGKGRVADYIPELAKASATDFGMAIVTP.RGEVFRVG
  44 ------------NKLQQAVDQAYTQFHSLNGGQNADYIPFLANVPGQLAAVAIVTS.DGNVYSAG
  45 -----------TMPIPEYLHEILDDVRDTTSGELADYIPELKSADPNPLAVALCTV.NGHIYSAG
  46 --------------------LVEANRRYTKEGHVATYIPALAKVNPDQLGVCIYDLkENKEFSAG
  47 -------------PIPEYLHEILDDVRDTTSGELADYIPELKSADPNPLAVALCTV.NGHIYSAG
  48 -------------------EILDEVRPLIGRGKVADYIPALAGVEPNQLGIAVYSR.DGELFHAG
  49 ------------------EALVKKAKKVTDKGEVASYIPALAKADKHDLSVAIYYS.NNVCLSAG
  50 --------------------------------------------------------.--------
  51 -----------------LEQIVLECKKYTEEGTVASYIPALAKADVSTLGIAIYRG.GDEQVIAG
  52 ------------------ERIAEEIERTPGSGRPADYIPALAARDPRRFGMAVAEL.DGTVYGVG
  53 ------GHLPDPETVVKLVQEAHKRFSTDTAGVVSNVYPALERIPADLFGICMVGT.NGKIHSAG
  54 -------------------EVAVLVRPHFGKGKPADYIPQLATVPGGKFGMAVRMV.DGDEHVIG
  55 -------------SFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTV.DGQRHSTG
  56 ---------FDRLDTVDLSNWVTLAKTKTNCGRVVERIPKLAVADTAWFAVHICCQ.SGKFYSEG
  57 --------------------------------------------------------.--------
  58 ---AMAIANYRAITTKQWQTWVEAARLQALNGKLPQYIPQLSLVDPGNFALDIGDQ.NGIIYEAG
  59 --------------------------------------------------------.--------
  60 --------------------------------------------------------.--------
  61 --------------------------------------------------------.--------
  62 --------------------------------------------------------.--------
  63 --------------------------------------------------------.--------
  64 --------------------------------------------------------.--------
  65 --------------------------------------------------------.--------
  66 ---------------------------------------------DSFFSVAVCSN.DGQFWGND
  67 --------------------------------------------------------.--------
  68 --------------------------------------------------------.--------
  69 ----------------------------ATGGKNADYIPFLASVPSDLFGLAVVTA.DGQTFKTG
  70 --------------------------------------------------------.--------
  71 QAFRKKFVIPDFEEFTGHVDRIFEDAKEPTGGKVAAYIPHLAKSNPDLWGVSLCTV.DGQRHSVG


            70        80        90       100       110       120       
            |         |         |         |         |         |       
   1 DW..NVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPTGDAFNSIIRLEINKPGKPFNPMINA
   2 DT..KVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLF---LNEDDKPHNPMVNA
   3 DT..KVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLF---LNEDDKPHNPMVNA
   4 DT..KVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLF---LNEDDKPHNPMVNA
   5 DT..KVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLF---LNEDDKPHNPMVNA
   6 DT..KVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLF---LNEDDKPHNPMVNA
   7 DT..KVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLL---LNEDDKPHNPMVNA
   8 DT..KVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLF---LNEDDKPHNPMVNA
   9 DV..DVPFTLQSCSKPLTYAIALEKLGPKVVHSYVGQEPSGRNFNELV---LDQNKKPHNPMINA
  10 DV..DVPFTLQSCSKPLTYAIALEKLGPKVVHSYVGQEPSGRNFNELV---LDQNKKPHNPMINA
  11 DV..DVPFTLQSCSKPLTYAIALEKLGPKVVHSYVGQEPSGRNFNELV---LDQNKKPHNPMINA
  12 DV..DVPFTLQSCSKPLTYAIALEKLGPKVVHSYVGQEPSGRNFNELV---LDQNKKPHNPMINA
  13 DV..DVPFTLQSCSKPLTYAIALEKLGPKVVHSYVGQEPSGRNFNELV---LDQNKKPHNPMINA
  14 DV..DVPFTLQSCSKPLTYAIALEKLGPKVVHSYVGQEPSGRNFNELV---LDQNKKPHNPMINA
  15 DV..DVPFTLQSCSKPLTYAIALEKLGPKVVHSYVGQEPSGRNFNELV---LDQNKKPHNPMINA
  16 HT..KIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLS---LNEEGIPHNPMVNA
  17 HT..KIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLS---LNEEGIPHNPMVNA
  18 HT..KIPFCLQSCVKPLTYAISVSTLGTDYVHKFVGKEPSGLRYNKLS---LNEEGIPHNPMVNA
  19 HT..KIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLS---LDEEGIPHNPMVNA
  20 DT..SVPFTLQSCSKPLTYAIALEKLGAQVVHQYIGQEPSGRNFNELV---LDYEKKPHNPMINA
  21 DS..KKNFCLQSVSKAFNYAIVASEIGSHVLHQYVGHEPSGRLFNEIC---LDSNNMPHNPLINA
  22 DS..KKNFCLQSVSKAFNYAIVASEIGSHVLHQYVGHEPSGRLFNEIC---LDSNNMPHNPLINA
  23 DS..KKNFCLQSVSKAFNYAIVASEIGSHVLHQYVGHEPSGRLFNEIC---LDSNNMPHNPLINA
  24 DV..KHPFCVQSVSKAFNYAIVASDLGADVVHSYVGQEPSGRLFNEIC---LDSTNKPHNPMVNS
  25 DV..KHPFCVQSVSKAFNYAIVASDLGADVVHSYVGQEPSGRLFNEIC---LDSTNKPHNPMVNS
  26 DA..LKPFCLQSVSKPFTYALVHDDIGPEELHAHVGQEPSGRLFNDIS---LDHNKKPHNPLINA
  27 DA..LKPFCLQSVSKPFTYALVHDDIGPEELHAHVGQEPSGRLFNDIS---LDHNKKPHNPLINA
  28 DW..NVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPTGDAFNSIIRLEINKPGKPFNPMINA
  29 DW..EIPFTLQSISKVIGFIAACLSRGISYVLERVDVEPTGDAFNSIIRLEIHKPGKPFNPMINA
  30 DY..QQLFTIQSISKVFAYGLALEDHGRDYVLTRVGVEPTGEAFNAIILDEQ--SKRPYNPMVNA
  31 DW..QVPFTLQSISKIINFIAACLDRGITYVLDRVDVEPTGDPFNSMVRLEMRKTGKPFNPMINA
  32 DA..QERFSIQSISKVLSLVVAMRHYSEEEIWQRVGKDPSGSPFNSLVQLEME-QGIPRNPFINA
  33 DA..DERFSIQSISKVLSLTLALSRYSEQDIWQRVGKEPSGQPFNSLVQLELE-KGKPRNPFINL
  34 DA..DIAFSIQSISKVFMLTLALGKVG-EGLWKRVGREPSGSTFNSIVQLEHE-SGIPRNPFINA
  35 DA..EMPFSIQSISKVFTLTLALGKHG-ENIWNRVGREPSGSAFNSIVQLEHE-GGKPRNPFINA
  36 DA..HERFSIQSISKVLSLVVAMRHYPEEEIWQRVGKDPSGSPFNSLVQLEME-QGIPRNPFINA
  37 NA..LVPFSIQSISKVFMLTLALGKAG-ETVWNRVGREPSGSSFNSIVQLEHE-HGIPRNPFVNA
  38 EY..DKKFTIQSISKVITLMLAILDNGKDRVFSRVGVEPTGDSFNSIVSLERKPSKKPFNPMVNS
  39 DA..DQAFSIQSISKVFTLTLALGNVG-DALWQRVGREPSGNPFNSIVQLEHE-NGIPRNPFINA
  40 DA..QEGFSIQSISKVLSLTLAMGLYQPDELWSRVGKEPSGQAFNSLIQLEME-QGIPRNPFINA
  41 DY..NTKFTIQSISKIISLMLAILDNGEEYVFSKVGMEPSGDPFNSIRKLETSSRKKPYNPMINA
  42 DS..DYRFALESISKVCTLALALEDVGPQAVQDKIGADPTGLPFNSVIALELH-GGKPLSPLVNA
  43 QA..ETLFSIQSISKLFACTLAFQLEG-ESLWQRVGREPSGNAFNSLVQLEHE-NGIPRNPFINA
  44 DS..DYRFALESISKVCTLALALEDVGPQAVQDKIGADPTGLPFNSVIALELH-GGKPLSPLVNA
  45 DD..DIEFTMQSISKPFAYALALQECGFDEVSASVALEPSGEAFNELS---LDGENRPMNPMINA
  46 EY..DVRFAIESISKVPTLILAILDNGIEKVFSEVGTEPSGFAFNSIMNMQINHKNKPSNPFINA
  47 DD..DIEFTMQSISKPFAYALALQECGFDEVSASVALEPSGEAFNELS---LDGENRPMNPMINA
  48 DA..LRPFSIQSISKVFSLVQAIQHSG-EDIWQRLGHEPSGQPFNSLVQLEFE-RGKPRNPFINA
  49 DV..EKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIKLETVNPSKPLNPMINA
  50 --..----------------IAVNDLGTEYVHRYVGKEPSGLRFNKLF---LNEDDKPHNPMVNA
  51 DA..DEKFTLQSISKVIALALALLDVGEEAVFSKVGMEPTGDPFNSISKLETSVPSKPLNPMINA
  52 DW..REPFSAQSLTKVFTLALDLAREG-DALWEHVGREPSGNPFNSLVQLEYE-NGIPRNPFINA
  53 DV..DYEFTIMSVSKPFVFALVCQAIGAKTAREKLGVNSTGMAFNSVTAIERA-SDGRTNPMVNS
  54 DA..DEGFSVQSITKVFALGLALNRLG-DEIWTRVGKEPSGTPFNHLSLLEAE-QGVPRNPFINA
  55 DT..KVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLF---LNEDDKPHNPMVNA
  56 DT..QCVFPLMSVIKPFTFLYLLEHMGVEKVLSWVGTKPSDAPFNSLEQLVAD-GGYPRNPMINS
  57 --..---------------------------------------------------------MVNA
  58 DT..DLTFSLMSVVKPFLWLYILHHRGWQWAEQKVGDRPSHLPFNSVEQLEQD-GGYPRNTMVNS
  59 --..-------------------------------------------------------------
  60 --..-------------------------------------------------------------
  61 --..---------------------------------EPTGDPFNSIIKLETTSPSKPLNPMINA
  62 --..-------------------------------------------------------------
  63 --..-------------------------------------------------------------
  64 --..-------------------------------------------------------------
  65 --..-------------------------------------------------------------
  66 DQlnDHCVPMFQVIYPFLYSILCEEIGLDEVSKFISDQARPDSYDN--QKPLNDQKKSHNPFTLA
  67 --..-------------------------------------------------------------
  68 --..---------------------------------------------------------MVNA
  69 DA..DIAFAIESISKVFTLALVMEEIGPDSVREKVGADPTGLPFNSVIALELH-NGKSLSPLVNA
  70 --..-------------------------------------------------------------
  71 HT..KIPFCLQSCVKPLTYAISVSTLGTDYVHKFVGKEPSGLRYNKLSLN---------------


      130            140       150        160        170        180    
       |              |         |          |          |          |    
   1 GALTIASIL.....PGESAYEKLEFLYSVMETLIGKR.PRIHEEVFRS.EWE.TAHRNRALAYYL
   2 GAIVVTSLIk....QGVNNAEKFDYVMQFLNKMAGNEyVGFSNATFQS.ERE.SGDRNFAIGYYL
   3 GAIVVTSLIk....QGVNNAEKFDYVMQFLNKMAGNEyVGFSNATFQS.ERE.SGDRNFAIGYYL
   4 GAIVVTSLIk....QGVNNAEKFDYVMQFLNKMAGNEyVGFSNATFQS.ERE.SGDRNFAIGYYL
   5 GAIVVTSLIk....QGVNNAEKFDYVMQFLNKMAGNEyVGFSNATFQS.ERE.SGDRNFAIGYYL
   6 GAIVVTSLIk....QGVNNAEKFDYVMQFLNKMAGNEyVGFSNATFQS.ERE.SGDRNFAIGYYL
   7 GAIVVTSLIk....QGVNNAEKFDYVMQFLNKMAGNEyVGFSNATFQS.ERE.SGDRNFAIGYYL
   8 GAIVVTSLIk....QGVNNAEKFDYVMQFLNKMAGNEyVGFSNATFQS.ERE.SGDRNFAIGYYL
   9 GAILTCSLMnalvkPDMTSAEIFDYTMSWFKRLSGGEyIGFNNAVFLS.ERE.AADRNYALGFYM
  10 GAILTCSLMnalvkPDMTSAEIFDYTMSWFKRLSGGEyIGFNNAVFLS.ERE.AADRNYALGFYM
  11 GAILTCSLMnalvkPDMTSAEIFDYTMSWFKRLSGGEyIGFNNAVFLS.ERE.AADRNYALGFYM
  12 GAILTCSLMnalvkPDMTSAEIFDYTMSWFKRLSGGEyIGFNNAVFLS.ERE.AADRNYALGFYM
  13 GAILTCSLMnalvkPDMTSAEIFDYTMSWFKRLSGGEyIGFNNAVFLS.ERE.AADRNYALGFYM
  14 GAILTCSLMnalvkPDMTSAEIFDYTMSWFKRLSGGEyIGFNNAVFLS.ERE.AADRNYALGFYM
  15 GAILTCSLMnalvkPDMTSAEIFDYTMSWFKRLSGGEyIGFNNAVFLS.ERE.AADRNYALGFYM
  16 GAIVVSSLIk....MDCNKAEKFDFVLQYLNKMAGNEyMGFSNATFQS.EKE.TGDRNYAIGYYL
  17 GAIVVSSLIk....MDCNKAEKFDFVLQYLNKMAGNEyMGFSNATFQS.EKE.TGDRNYAIGYYL
  18 GAIVVSSLIk....MDCNKAEKFDFVLQYLNKMAGNEfMGFSNATFQS.EKE.TGDRNYAIGYYL
  19 GAIVVSSLIk....MDCNKAEKFDFVLQYLNKMAGNEyMGFSNATFQS.EKE.TGDRNYAIGYYH
  20 GAILTCSLLktlvhPEMTLAEKFDYAQTWFSRMAGNEpLGFNNAVFLS.ERE.AADRNYALGFYM
  21 GAIVVTSMIk....PTHSMADRFDFMLKQYRKLAGGGhVGFDNATFLS.ERD.TADRNYALSYYM
  22 GAIVVTSMIk....PTHSMADRFDFMLKQYRKLAGGGhVGFDNATFLS.ERD.TADRNYALSYYM
  23 GAIVVTSMIk....PTHSMADRFDFMLKQYRKLAGGGhVGFDNATFLS.ERD.TADRNYALSYYM
  24 GAIVITSLIk....SKTNMADRFDFVLNQYRKIAGNEfIGFNNATFLS.ERA.TADRNYALSYFM
  25 GAIVITSLIk....SKTNMADRFDFVLNQYRKIAGNEfIGFNNATFLS.ERA.TADRNYALSYFM
  26 GAIVVASLLk....NKLPLADRFDFMIHACRKFVGSGyIGFDNSVFLS.ERE.TADRNYALSYYM
  27 GAIVVASLLk....NKLPLADRFDFMIHACRKFVGSGyIGFDNSVFLS.ERE.TADRNYALSYYM
  28 GALTIASIL.....PGESAYEKLEFLYSVMETLIGKR.PRIHEEVFRS.EWE.TAHRNRALAYYL
  29 GAITIASLL.....PGTSVQEKLESIYVLIEKMIEKR.PAINEIVFQS.EWE.TAHRNRALAYYL
  30 GAIATTSLI.....KGAGATERLNRVLEMFRRYIGHD.VFVDISVFTS.ERS.TGHRNRAMAHLM
  31 GAITVASLL.....SGKSPTEKLESVYSLVEKMLGRR.ASANEAVFHS.EWQ.TAHRNRSLAYYL
  32 GALVVCDML.....QGRLSAPRQRMLEVVRGLSGVSD.ISYDTVVARS.EFE.HSARNAAIAWLM
  33 GALVVCDML.....QSRLSAPKQRLLEVVRQLVKDDS.ISYDPRVARS.EFE.HSDRNAAIAYLM
  34 GAIAVTDVVm....AGHAPREAIGELLRFVRYLADDEsITIDDKVARS.ETQ.TGYRNVALANFM
  35 GAIRISDLIl....AGHTPKELIGEIVRFVRYLADDEnIVIDHEVARS.ETA.TGYRNIALANFM
  36 GALVVCDML.....QGRLSAPRQRMLEVVRALCGVSD.ITYDATVARS.EFE.HSARNAAIAWLM
  37 GAIVVTDIVl....SGHQPREAIGELLRFVRYLADDDtISIDDTVAKS.EQA.TGFRNFALANFM
  38 GAILTTSLI.....EGDSEEEKFERILEFTRKVTGNDdIQLNEDVYLS.EKE.TGDRNRALAYFM
  39 GAIVISDILl....AGHQPREAIGEILRFIQFLADDDtIIIDREVAAS.ERA.TGYRNFALANYM
  40 GAIVVCDML.....QSRLSAPRQRLLEFVRQLSGEPQ.IAYDKVVAAS.EMM.HSDRNAAIAYLM
  41 GAIAVASMI.....KGKDDREKFSRLLNFAKLITEDDsLDLNYKIYIG.ESD.TGFRNYSMAYFL
  42 GAIATTSLI.....NAENVEQRWQRILHIQQQLAGEQ.VALSDEVNQS.EQT.TNFHNRAIAWLL
  43 GALVVTDVL.....CRRFVQAETAMVQFMRRLVDNPR.VDYNPRVALS.ELE.HADRNRAMAHFM
  44 GAIATTSLI.....NAENAEQRWQRILHIQQQLAGEL.VALSDEVNQS.EQT.TNFHNRAIAWLL
  45 GAIAINQLIng...SDSTVEDRVEKIRHYFSELAGRE.LTIDRVLAES.ELA.GADRNLSIAHML
  46 GAIKVVSLL.....KGKNDEERFKRILDFYRKIMNDDeITLDTEIYLS.ERE.TGDINRSLAYYM
  47 GAIAINQLIng...SDSTVEDRVEKIRHYFSELAGRE.LTIDRVLAES.ELA.GADRNLSIAHML
  48 GALVICDIN.....QSRFAAPAQSMRDFVRRLCGNPE.VVSDSVVARS.EYQ.HRSRNAAAAYLM
  49 GALVVTSLI.....RGRTVKERLDYLLSFIRRLTNNQeITYCREVAES.EYS.TSMINRAMCYYM
  50 GAIVVTSLIk....QGVNNAEKFDYVMQFLNKMAGNEyVGFSNATFQS.ERE.SGDRNFAIGYYL
  51 GALAVTNMI.....IGETTEQSLGRLLSFIHELTKNPtITYNLEVAQS.EFD.TAFLNRSLSYFL
  52 GALVVTDRL.....HTRTGDAAGELLAFLRAESGNPD.LGHDEEVAAS.EAA.HGDRNAALAHFM
  53 GAIATTSLV.....PGATSDEQWKFIYDGLCRFAGRE.LTLNEEVYQS.ACE.TNFRNRGIANVL
  54 GALAVTDVL.....MDVTRDPA-ALVRDFGGFLCGER.LEIDPAVATS.ELA.HAWQNRAIASLM
  55 GAIVVTSLIk....QGVNNAEKFDYVMQFLNKMAGNEyVGFSNATFQS.ERE.SGDRNFAIGYYL
  56 GAITLADKL.....PGEDADHRTRFFCKWLNQLAGSQ.IQLDESMLASvRLS.RSPANQAIANYL
  57 GAIVVTSLIk....QGVNNAEKFDYVMQFLNKMAGNEyVGFSNATFQS.ERE.SGDRNFAIGYYL
  58 GAICLAGHI.....PGATIEQRCENFLTWLNHTAQCQ.LWLDQELLAS.VHSlPNPRNLAIAHLL
  59 ---------.....QGVNNAEKFDYVMQFLNKMAGNEyVGFSNATFQS.ERE.SGDRNFAIGYYL
  60 ---------.....-GVNNAEKFDYVMQFLNKMAGNEyVGFSNATFQS.ERE.SGDRNFAIGYYL
  61 GALAITSML.....AGKDNEEKMERILHFVREITDNPtINYSSKVANS.ELE.TAYLNRSLCYYM
  62 ---------.....PTHSMADRFDFMLKQYRKLAGGGhVGFDNATFLS.ERD.TADRNYALSYYM
  63 ---------.....PTHSMADRFDFMLKQYRKLAGGGhVGFDNATFLS.ERD.TADRNYALSYYM
  64 ---------.....-THSMADRFDFMLKQYRKLAGGGhVGFDNATFLS.ERD.TADRNYALSYYM
  65 ---------.....-THSMADRFDFMLKQYRKLAGGGhVGFDNATFLS.ERD.TADRNYALSYYM
  66 GQLITANLSlvn..IQMHVLESTQFLNIIQELVNCSS.VSCDMVSYLS.QKS.ETSDEILVGHLL
  67 ---------.....-----------------------.----------.---.------------
  68 GAIVVSSLIk....MDCNKAEKFDFVLQYLNKMAGNEfMGFSNATFQS.EKE.TGDRNYAIGYYL
  69 GAIATASLV.....PGDTADARWNNILECQCGFAGRR.LKLSNEVNQS.NR-.------------
  70 ---------.....-----------------------.----------.---.------------
  71 ---------.....-----------------------.----------.---.------------


         190              200       210       220       230            
          |                |         |         |         |            
   1 KETNFLEA..E.....VEETLEVYLKQCAMESTTEDIALIGLILAHDGYHPIRHEQVIPK.....
   2 KEKKCFPEgtD.....MVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSP.....
   3 KEKKCFPEgtD.....MVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSP.....
   4 KEKKCFPEgtD.....MVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSP.....
   5 KEKKCFPEgtD.....MVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSP.....
   6 KEKKCFPEgtD.....MVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSP.....
   7 KEKKCFPEgtD.....MVGILDFYFQLFSIEVTCESASVMAATLANGGFCPITGERVLSP.....
   8 KEKKCFPEgtD.....MVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSP.....
   9 RENKCFPKrtN.....LKEVMDFYFQCCSMETNCEAMSVIAASLANGGICPTTEEKVFRP.....
  10 RENKCFPKrtN.....LKEVMDFYFQCCSMETNCEAMSVIAASLANGGICPTTEEKVFRP.....
  11 RENKCFPKrtN.....LKEVMDFYFQCCSMETNCEAMSVIAASLANGGICPTTEEKVFRP.....
  12 RENKCFPKrtN.....LKEVMDFYFQCCSMETNCEAMSVIAASLANGGICPTTEEKVFRP.....
  13 RENKCFPKrtN.....LKEVMDFYFQCCSMETNCEAMSVIAASLANGGICPTTEEKVFRP.....
  14 RENKCFPKrtN.....LKEVMDFYFQCCSMETNCEAMSVIAASLANGGICPTTEEKVFRP.....
  15 RENKCFPKrtN.....LKEVMDFYFQCCSMETNCEAMSVIAASLANGGICPTTEEKVFRP.....
  16 KEKKCFPKgvD.....MMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSA.....
  17 KEKKCFPKgvD.....MMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSA.....
  18 KEKKCFPNpvD.....MMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSA.....
  19 EEKKCFPKgvD.....MMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSA.....
  20 REHKCYPEkaN.....LRECMDFYFQICSMEATCDTLSVVAATLANGGICPLTEERVLQS.....
  21 KEYRCFPD..Esq9kgLREELDLYFQLCSLETNCDTAAVMAATLANGGICPLTTEKCLGS.....
  22 KEYRCFPD..Esq9kgLREELDLYFQLCSLETNCDTAAVMAATLANGGICPLTTEKCLGS.....
  23 KEYRCFPD..Esq9kgLREELDLYFQLCSLETNCDTAAVMAATLANGGICPLTTEKCLGS.....
  24 KENRCFPK..Etes..LTDALDFYFQLCSVEVTCESLAVMASTLANGGVCPITNETCVDP.....
  25 KENRCFPK..Etes..LTDALDFYFQLCSVEVTCESLAVMASTLANGGVCPITNETCVDP.....
  26 REHKVFPKdlN.....LQDTLDLYFQICSIETNCDSLAVMAATLANGGVNPMNGERIVNN.....
  27 REHKVFPKdlN.....LQDTLDLYFQICSIETNCDSLAVMAATLANGGVNPMNGERIVNN.....
  28 KETNFLEA..E.....VEETLEVYLKQCAMESTTEDIALIGLILAHDGYHPIRHEQVIPK.....
  29 KENGFLES..D.....VEETLEVYLKQCSIEINTEDIALIGLILAHDGYHPIRKEQVLPK.....
  30 LNFGMIDR..N.....IEEALDLYFQQCAVMVNCHDLAVMAATLANRGVNPITGEQAVNS.....
  31 KDTGYLES..E.....VDDALHVYFTLCAIEVATKDIAKIGLILANNGYDPLSHQQIFPK.....
  32 KSFGNFHH..D.....VTTVLQNYFHYCALKMSCVELARTFVFLANQGKAIHIDEPVVTP.....
  33 KSFGNFDN..D.....VLTVLQTYFHYCAMRMSCVELARCFVYLANQGRSISGSESLITP.....
  34 RAYRNLDH..P.....VDHVLGVYFHQCALAMSCEQLARAGLFLAARGSNPMTGHSVVSP.....
  35 RSFGRLDH..P.....VEHVLGVYFHHCALAMTCSQLAKAGLFLAAGGTNPLTGHSVVSR.....
  36 KSFGNFHH..D.....VPTVLQNYFHYCALKMSCMELARTFVFLANQGEAFHLDEPVVTP.....
  37 RSFGNLHH..P.....VEHTLGVYFHQCALSMTCAQLSRAGLFLANRGRNPLSGHTVVSD.....
  38 KSNGVIEG..N.....IDDILDLYFKQCSLEVNAKDLARFGAMLANDGVLPWNGERVISR.....
  39 KSFGNLHH..A.....PELALGVYFHHCAIAMSCRQLAMAGRFLANGGKNPATGHSVVSA.....
  40 RSFGNFHN..E.....VIPVLHNYFHACALKMSCVELAKTFSYLANKGVSVVTGETVITP.....
  41 KGEGIIEG..N.....VNEALTVYFKQCSIEGTAKTISTLGKFLANDGVL-SNGERILTT.....
  42 YSAGYLYC..D.....AMEACDVYTRQCSTLLNTIELATLGATLAAGGVNPLTHKRVLQA.....
  43 RSFGNLHM..P.....VETVIDAYCRQCAIEMHCVDLARAVLFLANGGVVPWSGERVIET.....
  44 YSAGYLYC..D.....AMEACDVYTRQCSTLINTVELATLGATLAAGGVNPLTHKRVLQA.....
  45 RNYGVIED..E.....AHDAVLSYTLQCAIKVTTRDLAVMTATLAAGGTHPITGKKLLDA.....
  46 KGNGIMEG..D.....VTDILDSYFKQCSVLVTAKDLARLGAVLANEGVMPWNGERLFSV.....
  47 RNYGVIED..E.....AHDAVLSYTLQCAIKVTTRDLAVMTATLAAGGTHPITGKKLLDA.....
  48 KSFGNFHN..D.....VEAVLFSYFHHCALRMSCVDLARAFCFLADKGFCKHSGEQVLNE.....
  49 KQYGIFED..D.....VEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGRHPETGEQVISK.....
  50 KEKKCFPEgtD.....MVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSP.....
  51 KQHGVIQA..D.....VEQLLDLYTKQCAIEMCCSDLARIGYVFANEGRDPDTGQRIVPL.....
  52 ASYGNIDN..P.....VPVLLDQYFRQCSVAASCADLALATGFLARHGIR-ADGTRLLSR.....
  53 QGYGRLGC..D.....PIIATDLYTRQCSLNVSARDLAVMGATLADGGVNPLTRERVVDN.....
  54 RAKGTITH..D.....PEAVVAAYCRQCALSMSCRQLARAFLPLAAGGFSPIAQETVFPE.....
  55 KEKKCFPEgtD.....MVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSP.....
  56 AEKGYLE-..D.....LDVALDTYEQICCLSGTVEDLALLGKLLAL-------ESSSISP.....
  57 KEKKCFPEgtD.....MVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSP.....
  58 AAKGYVE-..D.....ATLALETYNQLCCLSGCLKDLFKLGLMLQC-------PQPPLQP.....
  59 KEKKCFPEgtD.....MVGILDFYFQLCSIEVTCEXASVMAATLANGGFCPITGERVLSP.....
  60 KEKKCFPEgtD.....MVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSP.....
  61 KQNGIIDC..D.....IEELMDLYTRQCAVEVNCIDLARIGLIFAMDGYDPYKKKQIIPK.....
  62 KEYRCFPD..Esq9kgLREELDLYFQLCSLETNCDTAAVMAATLANGGICPLTTEKCLGS.....
  63 KEYRCFPD..Esq9kgLREELDLYFQLCSLETNCDTAAVMAATLANGGICPLTTEKCLGS.....
  64 KEYRCFPD..Esq9kgLREELDLYFQLCSLETNCDTAAVMAATLANGGICPLTTEKCLGS.....
  65 KEYRCFPD..Esq9kgLREELDLYFQLCSLETNCDTAAVMAATLANGGICPLTTEKCLGS.....
  66 KSSGLIK-..Q.....PDDVLDFFYQINSIQLNSKQVSVLAATLANDGVCPFSQDLKLAPkn8ti
  67 --------..-.....---ALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSA.....
  68 KEKKCFPKgvD.....MMATLDLYFQLCSVEVTCESGSVMAATLANGGISPITRESVLSA.....
  69 --------..-.....--------------------------------------------.....
  70 --------..-.....---AVDIYTRQCSTLVTATDLATMGATLAAGGVNPISGKRMVSA.....
  71 --------..-.....--------------------------------------------.....


      240       250       260       270       280       290       300  
       |         |         |         |         |         |         |  
   1 DVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIMALVPPSARREQPFQSGCGIGIYGPAI
   2 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVP----------NVMGMMCWSPPL
   3 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVP----------NVMGMMCWSPPL
   4 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVP----------NVMGMMCWSPPL
   5 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVP----------NVMGMMCWSPPL
   6 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVP----------NVMGMMCWSPPL
   7 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVP----------NVMGMMCWSPPL
   8 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVP----------NVMGMMCWSPLL
   9 EVIRDVLSIMHSCGTYDYSGQFAFKVGLPAKSGVSGGMMLVIP----------NVMGIFAWSPPL
  10 EVIRDVLSIMHSCGTYDYSGQFAFKVGLPAKSGVSGGMMLVIP----------NVMGIFAWSPPL
  11 EVIRDVLSIMHSCGTYDYSGQFAFKVGLPAKSGVSGGMMLVIP----------NVMGIFAWSPPL
  12 EVIRDVLSIMHSCGTYDYSGQFAFKVGLPAKSGVSGGMMLVIP----------NVMGIFAWSPPL
  13 EVIRDVLSIMHSCGTYDYSGQFAFKVGLPAKSGVSGGMMLVIP----------NVMGIFAWSPPL
  14 EVIRDVLSIMHSCGTYDYSGQFAFKVGLPAKSGVSGGMMLVIP----------NVMGIFAWSPPL
  15 EVIRDVLSIMHSCGTYDYSGQFAFKVGLPAKSGVSGGMMLVIP----------NVMGIFAWSPPL
  16 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVP----------NVMGMMCLSPPL
  17 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVP----------NVMGMMCLSPPL
  18 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVP----------NVMGMMCLSPPL
  19 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVP----------NVMGMMCLSPPL
  20 ENVRDVLSLMHSCGMYDFSGQFAFKVGLPAKSGVCGGVMLVIP----------NVMGMFMWSPPL
  21 RPCRDILSLMYSCGMYDYSGKFAFQVGLPAKSGVSGIMIVVIP----------NVMGIALYSPPL
  22 RPCRDILSLMYSCGMYDYSGKFAFQVGLPAKSGVSGIMIVVIP----------NVMGIALYSPPL
  23 RPCRDILSLMYSCGMYDYSGKFAFQVGLPAKSGVSGIMIVVIP----------NVMGIALYSPPL
  24 NPCRDVLSLMYSCGMYDASGQFSFNVGLPAKSGVSGAMIVVVP----------NVMGICLFSPPL
  25 NPCRDVLSLMYSCGMYDASGQFSFNVGLPAKSGVSGAMIVVVP----------NVMGICLFSPPL
  26 RACRDTLSLMYSCGMYDWSGQFAFHVGLPAKSGVSGDMIIVIP----------NVMGIALYSPRL
  27 RACRDTLSLMYSCGMYDWSGQFAFHVGLPAKSGVSGDMIIVIP----------NVMGIALYSPRL
  28 DVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIMALVPPSARREQPFQSGCGIGIYGPAI
  29 EVARLTKALMLTCGMYNASGKFAAFIGLPAKSGVSGGIMTLVPSKSRKDLSFQDGCGIGIYGPAI
  30 RYIKDILSVMYTCGMYNFAGEWAYKVGIPAKSGVCGGIMAVVP----------NLMGIAVFSPPL
  31 EVAKLTKALMLTCGMYNASGTFAAHIGIPAKSGVSGGIMAAVPARGRSD----EAMGIGIYGPAI
  32 MQARQINALMATSGMYQNAGEFAWRVGLPAKSGVGGGIVAIVP----------HEMAIAVWSPEL
  33 MQARQINALMITSGMYDGAGEFAFRVGMPGKSGVGGGIIAIVP----------DEFCIAVWSPEL
  34 KRARRINALMLTCGHYDGSGDFAYHVGLPGKSGVGGGIFAVAP----------GIASIAVWSPGL
  35 QRARRINALMLTCGHYDGSGDFAYRVGLPGKSGVGGGIMAVAP----------GKASIAVWSPGL
  36 MQARQINALMATSGMYQNAGEFAWRVGLPAKSGVGGGIVAIVP----------HEMAIAVWSPEL
  37 RRARRINALMLTCGHYDGSGDFAYHVGLPGKSGVGGGIMAVAP----------GNASIAVWSPGL
  38 EICRIIKTIMVTCGMYDDSGKFAVHIGIPAKSGVGGGIMAAVP----------RRMGIGIFGPSL
  39 ERARRIGAMMLTCGHYDGSGDFAFRVGIPGKSGVGGGILGIVP----------GVASLAVWSPGL
  40 TQSKQTNALLATCGLYDGAGEFAYRVGMPGKSGVGGGIIAVVP----------GEMTIAVWSPAL
  41 RMAKIIKTLMVTCGMYDSSGEFAVRVGIPSKSGVGGGICSVVP----------GKMGIGVYGPSL
  42 DNVPYILAEMMMEGLYGRSGDWAYRVGLPGKSGVGGGILAVVP----------GVMGIAAFSPPL
  43 SPAKRLSALMLTCGTYDAAGDFVYRVGLPAKSGVGGGIVAVLP----------GEFGVCVWSPGL
  44 DNVPYILAEMMMEGLYGRSGDWAYRVGLPGKSGVGGGILAVVP----------GVMGIAAFSPPL
  45 RVCRLTLSVMASAGMYDEAGQWLSTVGIPAKSGVAGGLIGILP----------GQLGIATFSPRL
  46 ETATVVKSLMTTYGLYDESGAFSVHIGLPSKSGVGGGILSSVP----------NKCGIGLFSPAL
  47 RVCRLTLSVMASAGMYDEAGQWLSTVGIPAKSGVAGGLIGILP----------GQLGIATFSPRL
  48 RQTKQVNAIMATSGLYDEAGNFAYRVGLPGKSGVGGGIIAVVP----------GRFTVCVWSPEL
  49 DVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISP----------YDFGIGIFGPAL
  50 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVP----------NVMGMMCWSPPL
  51 HVARIIKTFMVTCGMYNASGEFAIRVGIPAKSGVSGAILALVP----------NKYGIAVYSPAL
  52 SRAKQINAVMLTCGTYDAAGDFAHRVGLPGKSGVGGGIIAVVP----------GHCTLCVWGPGL
  53 DICHYALAVMVTAGLYETSGDWLYDIGLPGKSGIGGGIVTVSP----------GKGGLGTFAPLL
  54 RLTRRLNALLLTCGIYDSVGSFAYRVGLPAKSGVGGGIVAVVP----------GKATVAVWSPEL
  55 EAVRNTLSLMHSCGMY-------------------------------------------------
  56 QHQQLVNSVMLTCGLYEASAEYAVTIGLPMKSGIGGGLLAIVP----------TAGAIACYSPAL
  57 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVP----------NVMGMMCWSPPL
  58 DTTARVKATMAKAGLYEMSEAFFRRTGFICKSGVSGLILACLP--------APSPTIFACYSPPL
  59 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVP----------NVMGMMCWSPPL
  60 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVP----------NVMGMMCWSPPL
  61 HITKICKTFMVTCGMYNESGEFAIRVGIPAKSGVAGGIFGCVK----------GEMGIGIFGPAL
  62 RPCRDILSLMYSCGMYDYSGKFAFQVGLPAKSGVSGIMIVVIP----------NVMGIALYSPPL
  63 RPCRDILSLMYSCGMYDYSGKFAFQVGLPAKSGVSGIMIVVIP----------NVMGIALYSPPL
  64 RPCRDILSLMYSCGMYDYSGKFAFQVGLPAKSGVSGIMIVVIP----------NVMGIALYSPPL
  65 RPCRDILSLMYSCGMYDYSGKFAFQVGLPAKSGVSGIMIVVIP----------NVMGIALYSPPL
  66 DLIRICNSTPITSSIFDNNIDNINNSKIIPILSDSGVLMIIIP----------GLMGVSIISPC-
  67 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVP----------NVMGMMCLSPPL
  68 EAVRNTLSLMHSCGMY-------------------------------------------------
  69 -----------------------------------------------------------------
  70 GNVAPILAEMTMEGLYTALGDWAYTVGLPGKSGVGGGIMAVVP----------GELAIAAFSPPL
  71 -----------------------------------------------------------------


           310       320       
            |         |       
   1 DEYGNSLTGGMLLKHMAQEWELSIF
   2 DKMGNSVKGIHFCHDLVSLCNFHNY
   3 DKMGNSVKGIHFCHDLVSLCNFHNY
   4 DKMGNSVKGIHFCHDLVSLCNFHNY
   5 DKMGNSVKGIHFCHDLVSLCNFHNY
   6 DKMGNSVKGIHFCHDLVSLCNFHNY
   7 DKMGNSVKGIHFCHDLVSLCNFHNY
   8 DKMGNSVKGIHFCHDLVSLCNFHNY
   9 DHLGNTVRGLQFCEELVSMFNFHRY
  10 DHLGNTVRGLQFCEELVSMFNFHRY
  11 DHLGNTVRGLQFCEELVSMFNFHRY
  12 DHLGNTVRGLQFCEELVSMFNFHRY
  13 DHLGNTVRGLQFCEELVSMFNFHRY
  14 DHLGNTVRGLQFCEELVSMFNFHRY
  15 DHLGNTVRGLQFCEELVSMFNFHRY
  16 DKLGNSHRGTSFCQKLVSLFNFHNY
  17 DKLGNSHRGTSFCQKLVSLFNFHNY
  18 DKLGNSHRGISFCQKLVSLFNFHNY
  19 DKLGNSHRGTSFCQKLVSLFNFHNY
  20 DPLGNSCRGVQFCKELVDVFNFHLY
  21 DKTGNSCRGVAFCRQLIDKFNFHNY
  22 DKTGNSCRGVAFCRQLIDKFNFHNY
  23 DKTGNSCRGVAFCRQLIDKFNFHNY
  24 DSLGNSCRGVAFCKKLVSTFNFHNY
  25 DSLGNSCRGVAFCKKLVSTFNFHNY
  26 DKLGNTVRGVKFAEQLVQKYNFHNY
  27 DKLGNTVRGVKFAEQLVQKYNFHNY
  28 DEYGNSLTGGMLLKHMAQEWELSIF
  29 DEYGNSLPGIMLLEHIAKEWDLSIF
  30 DIRGNSVRGVKVCEELSQQLGLHLF
  31 DDFGNSVAGVALLKHLSHMWDLSIF
  32 DDAGNSLAGIAVLEQLTKQLGRSVY
  33 DHAGNSLAGTAALERLAQQMGRSIF
  34 NKVGNSQLGAVALEMLAARTGWSVF
  35 NDYGNSLLGSLALEMLAARTGWSVF
  36 DPAGNSLAGIAALEQLTQTLGRSVY
  37 NKVGNSALGSQALELLATKTGWSVF
  38 DDKGNSIAGTHVMKDLSEELDLSIF
  39 NANGNSKLGSIALEKLARMMNWSIF
  40 DQSGNSLAGTRALELLAQRIGRSIF
  41 DKKGNSLAGGHLLEDLSAELSLNIF
  42 DEDGNSVRGQKMVASVAKQLGYNVF
  43 DVSGNSLAGLQALEWLTTLSGRSIF
  44 DEEGNSVRGQKMVASVAKQLGYNVF
  45 NPKGNSVRGVKIFKQLSDDMGLH--
  46 DVSGNSVASMKLLKEIADKLKLDIF
  47 NPKGNSVRGVKIFKQLSDDMGLH--
  48 NAAGNSLAGIAALEKLSERIGWSIF
  49 DEKGNSIAGVKLLEIMSEMYRLSIF
  50 DKMGNSVKGIHFCHDLVSLCNFHNY
  51 DEKGNSLAGIKLLETLSCREEWSIF
  52 DERGNSVAGVAALDRFTTLTGLSVF
  53 DSAGNSIKGQLAARFLSRSLGMDMF
  54 DRFGTSVVGTAALEAFSQITNCS--
  55 -------------------------
  56 DRIGNPVGAIAFVEVLSRSL-----
  57 DKMGNSVKGIHFCHDLVSLCNFHNY
  58 NEEGNPVAPLALLEFLAEF------
  59 DKMGNSVKGIHFCHDLVSLCNFHNY
  60 DKMGNSVKGIHFCHDLVSLCNFHNY
  61 DANGNSIAGFKILELLSAQEGWSIF
  62 DKTGNSCRGVAFCRQLIDKFNFHNY
  63 DKTGNSCRGVAFCRQLIDKFNFHNY
  64 DKTGNSCRGVAFCRQLIDKFNFHNY
  65 DKTGNSCRGVAFCRQLIDKFNFHNY
  66 -------------------------
  67 DKLGNSHRGTSFCQKLVSLFNFHNY
  68 -------------------------
  69 -------------------------
  70 DPAGNSVKAMAAVAAVADSLGHNLY
  71 -------------------------