(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0159 Glycine betaine-binding periplasmic protein, E. coli
    • gi|15832796|ref|NP_311569.1|_22:330 (NC_002695) high-affinity glycine betaine / proline transport system protein [Escherichia coli O157:H7]
    • gi|16130593|ref|NP_417165.1| (NC_000913) high-affinity transport system for glycine betaine and proline [Escherichia coli K12]
    • gi|130994sp|P14177|PROX_ECOLI Glycine betaine-binding periplasmic protein precursor
    • gi|72506|pir||BLECGP glycine betaine/proline transport system binding protein proX precursor - Escherichia coli
    • gi|147375|gb|AAA24429.1| (M24856) proX peptide precursor [Escherichia coli]
    • gi|1789034|gb|AAC75726.1| (AE000352) high-affinity transport system for glycine betaine and proline [Escherichia coli K12]
    • gi|1800067|dbj|BAA16544.1| (D90891) GLYCINE BETAINE-BINDING PERIPLASMIC PROTEIN PRECURSOR. [Escherichia coli]
    • gi|13363013|dbj|BAB36965.1| (AP002562) high-affinity glycine betaine / proline transport system protein [Escherichia coli O157:H7]
    • gi|15803199|ref|NP_289231.1|_22:330 (NC_002655) high-affinity transport system for glycine betaine and proline [Escherichia coli O157:H7 EDL933]
    • gi|12517118|gb|AAG57789.1|AE005496_12 (AE005496) high-affinity transport system for glycine betaine and proline [Escherichia coli O157:H7 EDL933]
    • gi|16761592|ref|NP_457209.1|_22:331 (NC_003198) glycine betaine-binding periplasmic protein precursor [Salmonella enterica subsp. enterica serovar Typhi]
    • gi|16503893|emb|CAD05922.1| (AL627276) glycine betaine-binding periplasmic protein precursor [Salmonella enterica subsp. enterica serovar Typhi]
    • gi|16766122|ref|NP_461737.1|_22:331 (NC_003197) ABC superfamily (bind_prot), glycine/betaine/proline transport protein [Salmonella typhimurium LT2]
    • gi|16421360|gb|AAL21696.1| (AE008828) ABC superfamily (bind_prot), glycine/betaine/proline transport protein [Salmonella typhimurium LT2]
    • gi|15600571|ref|NP_254065.1|_21:291 (NC_002516) hypothetical protein [Pseudomonas aeruginosa]
    • gi|11350430|pir||C82974 hypothetical protein PA5378 [imported] - Pseudomonas aeruginosa (strain PAO1)
    • gi|9951701|gb|AAG08763.1|AE004950_6 (AE004950) hypothetical protein [Pseudomonas aeruginosa]
    • gi|16264144|ref|NP_436936.1|_21:291 (NC_003078) putative glycine-betaine-binding protein [Sinorhizobium meliloti]
    • gi|15140269|emb|CAC48796.1| (AL603643) putative glycine-betaine-binding protein [Sinorhizobium meliloti]
    • gi|16122854|ref|NP_406167.1|_22:324 (NC_003143) glycine betaine-binding periplasmic protein [Yersinia pestis]
    • gi|15980628|emb|CAC92886.1| (AJ414153) glycine betaine-binding periplasmic protein [Yersinia pestis]
    • gi|17936164|ref|NP_532954.1|_25:295 (NC_003304) ABC transporter, substrate binding protein [proline/glycine betaine] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|17740757|gb|AAL43270.1| (AE009177) ABC transporter, substrate binding protein [proline/glycine betaine] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15966453|ref|NP_386806.1|_26:337 (NC_003047) HISTIDINE-BINDING PERIPLASMIC SIGNAL PEPTIDE PROTEIN [Sinorhizobium meliloti]
    • gi|15075724|emb|CAC47279.1| (AL591791) HISTIDINE-BINDING PERIPLASMIC SIGNAL PEPTIDE PROTEIN [Sinorhizobium meliloti]
    • gi|15966152|ref|NP_386505.1|_27:298 (NC_003047) PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN [Sinorhizobium meliloti]
    • gi|15075422|emb|CAC46978.1| (AL591790) PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN [Sinorhizobium meliloti]
    • gi|19880073|gb|AAM00244.1|AF360731_1_18:289 (AF360731) ProX [Sinorhizobium meliloti]
    • gi|8650111|gb|AAF78097.1|AF111939_1_28:339 (AF111939) periplasmic binding protein [Sinorhizobium meliloti]
    • gi|17986724|ref|NP_539358.1|_35:305 (NC_003317) GLYCINE BETAINE/L-PROLINE-BINDING PROTEIN PROX [Brucella melitensis]
    • gi|17982349|gb|AAL51622.1| (AE009487) GLYCINE BETAINE/L-PROLINE-BINDING PROTEIN PROX [Brucella melitensis]
    • gi|15674389|ref|NP_268563.1|_316:573 (NC_002737) putative glycine-betaine binding permease protein [Streptococcus pyogenes] [Streptococcus pyogenes M1 GAS]
    • gi|13621479|gb|AAK33284.1| (AE006487) putative glycine-betaine binding permease protein [Streptococcus pyogenes M1 GAS]
    • gi|19745348|ref|NP_606484.1|_316:573 (NC_003485) putative glycine-betaine binding permease protein [Streptococcus pyogenes MGAS8232]
    • gi|19747452|gb|AAL96983.1| (AE009968) putative glycine-betaine binding permease protein [Streptococcus pyogenes MGAS8232]
    • gi|15891150|ref|NP_356822.1|_42:352 (NC_003063) AGR_L_2067p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|15159499|gb|AAK89607.1| (AE008303) AGR_L_2067p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17937505|ref|NP_534294.1|_28:338 (NC_003305) ABC transporter, substrate binding protein [proline/glycine betaine] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|17742231|gb|AAL44610.1| (AE009311) ABC transporter, substrate binding protein [proline/glycine betaine] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|21226144|ref|NP_632066.1|_39:303 (NC_003901) Glycine betaine transporter, substrate-binding protein [Methanosarcina mazei Goe1]
    • gi|19224204|gb|AAL86440.1|AF475089_3 (AF475089) substrate binding protein OtaC [Methanosarcina mazei]
    • gi|20904369|gb|AAM29738.1| (AE013223) Glycine betaine transporter, substrate-binding protein [Methanosarcina mazei Goe1]
    • gi|7542433|gb|AAF63445.1|AF218267_2_30:332 (AF218267) glycine betaine/L-proline-binding periplasmic protein [Pseudomonas putida]
    • gi|17938336|ref|NP_535125.1|_27:297 (NC_003305) conserved hypothetical protein [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|17743144|gb|AAL45441.1| (AE009393) conserved hypothetical protein [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15889346|ref|NP_355027.1|_48:320 (NC_003062) AGR_C_3730p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|15157190|gb|AAK87812.1| (AE008123) AGR_C_3730p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|15890343|ref|NP_356015.1|_73:343 (NC_003063) AGR_L_470p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|15158553|gb|AAK88800.1| (AE008222) AGR_L_470p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17935945|ref|NP_532735.1|_19:291 (NC_003304) ABC transporter, substrate binding protein [glycine betaine] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|17740518|gb|AAL43051.1| (AE009157) ABC transporter, substrate binding protein [glycine betaine] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|13472448|ref|NP_104015.1|_21:287 (NC_002678) ABC transporter binding protein [Mesorhizobium loti]
    • gi|14023194|dbj|BAB49801.1| (AP003000) ABC transporter binding protein [Mesorhizobium loti]
    • gi|6119854|gb|AAF04259.1|AF139575_2_314:571 (AF139575) glycine-betaine binding permease protein [Lactococcus lactis]
    • gi|7212814|gb|AAF40474.1|AF184955_2 (AF184955) OpuABC [Lactococcus lactis]
    • gi|15890925|ref|NP_356597.1|_114:419 (NC_003063) AGR_L_1618p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17937742|ref|NP_534531.1| (NC_003305) ABC transporter, substrate binding protein [glycine betaine] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15159235|gb|AAK89382.1| (AE008280) AGR_L_1618p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17742492|gb|AAL44847.1| (AE009335) ABC transporter, substrate binding protein [glycine betaine] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|18450327|ref|NP_569198.1|_29:288 (NC_003383) Pseudogene, similar to glycine-betaine binding (ABC transporter) [Listeria innocua]
    • gi|16415828|emb|CAC42043.1| (AL592102) Pseudogene, similar to glycine-betaine binding (ABC transporter) [Listeria innocua]
    • gi|15673433|ref|NP_267607.1|_314:571 (NC_002662) betaine ABC transporter permease and substrate binding protein [Lactococcus lactis subsp. lactis]
    • gi|7188801|gb|AAF37879.1|AF234619_2 (AF234619) OpuABC [Lactococcus lactis]
    • gi|12724442|gb|AAK05549.1|AE006375_3 (AE006375) betaine ABC transporter permease and substrate binding protein [Lactococcus lactis subsp. lactis]
    • gi|15888235|ref|NP_353916.1|_24:329 (NC_003062) AGR_C_1631p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17934803|ref|NP_531593.1| (NC_003304) ABC transporter, substrate binding protein [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15155887|gb|AAK86701.1| (AE008020) AGR_C_1631p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17739274|gb|AAL41909.1| (AE009055) ABC transporter, substrate binding protein [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|20090990|ref|NP_617065.1|_53:311 (NC_003552) glycine betaine/L-proline ABC transporter, solute-binding protein [Methanosarcina acetivorans str. C2A] [Methanosarcina acetivorans C2A]
    • gi|19916077|gb|AAM05545.1| (AE010901) glycine betaine/L-proline ABC transporter, solute-binding protein [Methanosarcina acetivorans str. C2A] [Methanosarcina acetivorans C2A]
    • gi|15600296|ref|NP_253790.1|_24:334 (NC_002516) hypothetical protein [Pseudomonas aeruginosa]
    • gi|11350362|pir||H83007 hypothetical protein PA5103 [imported] - Pseudomonas aeruginosa (strain PAO1)
    • gi|9951399|gb|AAG08488.1|AE004923_4 (AE004923) hypothetical protein [Pseudomonas aeruginosa]
    • gi|16263404|ref|NP_436197.1|_22:326 (NC_003037) putative periplasmic binding protein [Sinorhizobium meliloti]
    • gi|14524092|gb|AAK65609.1| (AE007281) putative periplasmic binding protein [Sinorhizobium meliloti]
    • gi|15595228|ref|NP_248720.1|_22:289 (NC_002516) hypothetical protein [Pseudomonas aeruginosa]
    • gi|11348728|pir||D83642 hypothetical protein PA0030 [imported] - Pseudomonas aeruginosa (strain PAO1)
    • gi|9945850|gb|AAG03420.1|AE004442_7 (AE004442) hypothetical protein [Pseudomonas aeruginosa]
    • gi|17548285|ref|NP_521625.1|_22:283 (NC_003296) PUTATIVE GLYCINE BETAINE TRANSMEMBRANE AND PERIPLASMIC ABC TRANSPORTER PROTEIN [Ralstonia solanacearum]
    • gi|17430531|emb|CAD17215.1| (AL646076) PUTATIVE GLYCINE BETAINE TRANSMEMBRANE AND PERIPLASMIC ABC TRANSPORTER PROTEIN [Ralstonia solanacearum]
    • gi|15889556|ref|NP_355237.1|_2:243 (NC_003062) AGR_C_4148p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|15157439|gb|AAK88022.1| (AE008143) AGR_C_4148p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|16119443|ref|NP_396149.1|_29:338 (NC_003064) AGR_pAT_305p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17938805|ref|NP_535593.1| (NC_003306) ABC transporter, nucleotide binding/ATPase protein [glycine betaine/L-proline] [Agrobacterium tumefaciens str. C58 (Dupont)] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15161979|gb|AAK90590.1| (AE007892) AGR_pAT_305p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17743655|gb|AAL45909.1| (AE008944) ABC transporter, nucleotide binding/ATPase protein [glycine betaine/L-proline] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15598432|ref|NP_251926.1|_22:284 (NC_002516) probable glycine betaine-binding protein precursor [Pseudomonas aeruginosa]
    • gi|11351343|pir||H83241 probable glycine betaine-binding protein precursor PA3236 [imported] - Pseudomonas aeruginosa (strain PAO1)
    • gi|9949358|gb|AAG06624.1|AE004746_8 (AE004746) probable glycine betaine-binding protein precursor [Pseudomonas aeruginosa]
    • gi|15594489|ref|NP_212278.1|_26:285 (NC_001318) glycine betaine, L-proline ABC transporter, glycine/betaine/L-proline-binding protein (proX) [Borrelia burgdorferi]
    • gi|7463192|pir||H70117 glycine betaine, L-proline ABC transporter, glycine/betaine/ L-proline-binding protein (proX) homolog - Lyme disease spirochete
    • gi|2688024|gb|AAC66525.1| (AE001125) glycine betaine, L-proline ABC transporter, glycine/betaine/L-proline-binding protein (proX) [Borrelia burgdorferi]
    • gi|15600289|ref|NP_253783.1|_27:314 (NC_002516) probable binding protein component of ABC transporter [Pseudomonas aeruginosa]
    • gi|11351117|pir||E83009 probable binding protein component of ABC transporter PA5096 [imported] - Pseudomonas aeruginosa (strain PAO1)
    • gi|9951391|gb|AAG08481.1|AE004922_6 (AE004922) probable binding protein component of ABC transporter [Pseudomonas aeruginosa]
    • gi|15891012|ref|NP_356684.1|_40:298 (NC_003063) AGR_L_1793p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|15159337|gb|AAK89469.1| (AE008288) AGR_L_1793p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17937654|ref|NP_534443.1|_28:286 (NC_003305) ABC transporter, substrate binding protein [glycine-betaine] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|17742395|gb|AAL44759.1| (AE009326) ABC transporter, substrate binding protein [glycine-betaine] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|17988895|ref|NP_541528.1|_21:285 (NC_003318) GLYCINE BETAINE/L-PROLINE-BINDING PROTEIN PROX [Brucella melitensis]
    • gi|17984722|gb|AAL53792.1| (AE009690) GLYCINE BETAINE/L-PROLINE-BINDING PROTEIN PROX [Brucella melitensis]
    • gi|21220116|ref|NP_625895.1|_334:593 (NC_003888) glycine betaine transport system permease protein [Streptomyces coelicolor A3(2)]
    • gi|6119662|emb|CAB59473.1| (AL132648) glycine betaine transport system permease protein [Streptomyces coelicolor A3(2)]
    • gi|13471881|ref|NP_103448.1|_22:319 (NC_002678) hypothetical protein [Mesorhizobium loti]
    • gi|14022625|dbj|BAB49234.1| (AP002998) hypothetical protein [Mesorhizobium loti]
    • gi|21220116|ref|NP_625895.1|_606:865 (NC_003888) glycine betaine transport system permease protein [Streptomyces coelicolor A3(2)]
    • gi|6119662|emb|CAB59473.1| (AL132648) glycine betaine transport system permease protein [Streptomyces coelicolor A3(2)]
    • gi|13476104|ref|NP_107674.1|_29:322 (NC_002678) ABC transporter binding protein [Mesorhizobium loti]
    • gi|14026864|dbj|BAB53460.1| (AP003011) ABC transporter binding protein [Mesorhizobium loti]
    • gi|15965818|ref|NP_386171.1|_17:312 (NC_003047) PUTATIVE AMINO ACID-BINDING PERIPLASMIC PROTEIN [Sinorhizobium meliloti]
    • gi|15075087|emb|CAC46644.1| (AL591789) PUTATIVE AMINO ACID-BINDING PERIPLASMIC PROTEIN [Sinorhizobium meliloti]
    • gi|15965718|ref|NP_386071.1|_23:325 (NC_003047) HYPOTHETICAL TRANSMEMBRANE PROTEIN [Sinorhizobium meliloti]
    • gi|15074987|emb|CAC46544.1| (AL591789) HYPOTHETICAL TRANSMEMBRANE PROTEIN [Sinorhizobium meliloti]
    • gi|21223209|ref|NP_628988.1|_37:321 (NC_003888) putative glycine betaine-binding lipoprotein [Streptomyces coelicolor A3(2)]
    • gi|9367462|emb|CAB97435.1| (AL389898) putative glycine betaine-binding lipoprotein [Streptomyces coelicolor A3(2)]
    • gi|21400684|ref|NP_656669.1|_24:195 (NC_003995) hypothetical protein predicted by GeneMark [Bacillus anthracis A2012] [Bacillus anthracis str. A2012]
    • gi|16077369|ref|NP_388182.1|_33:180 (NC_000964) glycine betaine ABC transporter (glycine betaine-binding protein) [Bacillus subtilis]
    • gi|1171921sp|P46922|OPAC_BACSU Glycine betaine-binding protein precursor
    • gi|2126948|pir||I40537 glycine betaine ABC transporter (glycine betaine-binding protein) opuAC precursor - Bacillus subtilis
    • gi|984805|gb|AAC43457.1| (U17292) glycine betaine-binding protein precursor [Bacillus subtilis]
    • gi|1805372|dbj|BAA08934.1| (D50453) glycine betain-binding protein precursor [Bacillus subtilis]
    • gi|2632586|emb|CAB12094.1| (Z99105) glycine betaine ABC transporter (glycine betaine-binding protein) [Bacillus subtilis]
    • gi|16800084|ref|NP_470352.1|_33:185 (NC_003212) highly similar to glycine betaine ABC transporters (glycine betaine-binding protein) [Listeria innocua]
    • gi|16413474|emb|CAC96246.1| (AL596167) highly similar to glycine betaine ABC transporters (glycine betaine-binding protein) [Listeria innocua]
    • gi|16803056|ref|NP_464541.1|_33:185 (NC_003210) highly similar to glycine betaine ABC transporters (glycine betaine-binding protein) [Listeria monocytogenes EGD-e]
    • gi|16410418|emb|CAC99094.1| (AL591977) highly similar to glycine betaine ABC transporters (glycine betaine-binding protein) [Listeria monocytogenes]
    • gi|4760365|gb|AAD29106.1|AF039835_3_33:185 (AF039835) putative glycine betaine binding protein GbuC [Listeria monocytogenes]
    • gi|1850605|gb|AAB48048.1|AAB48048_4:133 (U88582) ProX [Streptococcus mutans]
    • gi|7228268|emb|CAB77173.1|_22:151 (AJ238780) ORF1 [Halomonas elongata]
    • gi|16077369|ref|NP_388182.1|_188:292 (NC_000964) glycine betaine ABC transporter (glycine betaine-binding protein) [Bacillus subtilis]
    • gi|1171921sp|P46922|OPAC_BACSU Glycine betaine-binding protein precursor
    • gi|2126948|pir||I40537 glycine betaine ABC transporter (glycine betaine-binding protein) opuAC precursor - Bacillus subtilis
    • gi|984805|gb|AAC43457.1| (U17292) glycine betaine-binding protein precursor [Bacillus subtilis]
    • gi|1805372|dbj|BAA08934.1| (D50453) glycine betain-binding protein precursor [Bacillus subtilis]
    • gi|2632586|emb|CAB12094.1| (Z99105) glycine betaine ABC transporter (glycine betaine-binding protein) [Bacillus subtilis]
    • gi|16803056|ref|NP_464541.1|_193:297 (NC_003210) highly similar to glycine betaine ABC transporters (glycine betaine-binding protein) [Listeria monocytogenes EGD-e]
    • gi|16410418|emb|CAC99094.1| (AL591977) highly similar to glycine betaine ABC transporters (glycine betaine-binding protein) [Listeria monocytogenes]
    • gi|4760365|gb|AAD29106.1|AF039835_3_193:297 (AF039835) putative glycine betaine binding protein GbuC [Listeria monocytogenes]
    • gi|16800084|ref|NP_470352.1|_193:296 (NC_003212) highly similar to glycine betaine ABC transporters (glycine betaine-binding protein) [Listeria innocua]
    • gi|16413474|emb|CAC96246.1| (AL596167) highly similar to glycine betaine ABC transporters (glycine betaine-binding protein) [Listeria innocua] 
              10         20        30          40        50          60
              |          |         |           |         |           |
   1 ADLPGKGITVNPVQS.TITEETFQTLLVSRALE.KLGYTVN.KPSEVDYNVGY.TSL.ASGDATF
   2 ADLPGKGITVNPVQS.TITEETFQTLLVSRALE.KLGYTVN.KPSEVDYNVGY.TSL.ASGDATF
   3 ADLPGKGITVNPVQS.TITEETFQTLLVSRALE.KLGYTVN.KPSEVDYNVGY.TSL.ASGDATF
   4 ADLPGKGITVQPIQS.TISEESFQTLLVSRALE.KLGYTVN.KPSEVDYNVGY.TSI.ASGDATF
   5 ADLPGKGITVQPIQS.TISEETFQTLLVSRALE.KLGYTVN.KPSEVDYNVGY.TSI.ASGDATF
   6 AAEPESCASVRFADV.GWTDITVTTAVTRQVLE.SLGYKTK.-VNLLSVPVTY.RSL.ANNDLDV
   7 AAEPESCKTVRFSDV.GWTDITSTTAVASTILE.ALGYAPQ.-SKLLSIPVTY.ASM.KNKDIDV
   8 AELPGKGITVQPLQS.TISEETFQTSLVNKALE.KLGYDVQ.PTKEVDYNVAY.SSI.AAGDATY
   9 AAEPASCGTVRFSDV.GWTDITATTATATVLLK.SLGYETD.-VKLLSVPVTY.TSL.KNKDIDV
  10 ASYCGDGKTVTFAGI.DWESGAFITEVMKTILS.K-GYDCQ.VDSIPGNSVTLeQAT.ANNDVQI
  11 AAEPESCGTVRFSDV.GWTDITATTATATTILE.ALGYETD.-VKVLSVPVTY.TSL.KNKDIDV
  12 AAEPESCGTVRFSDV.GWTDITATTATATTILE.ALGYETD.-VKVLSVPVTY.TSL.KNKDIDV
  13 ASYCGDGKTVTFAGI.DWESGAFITEVMKTILS.K-GYDCQ.VDSIPGNSVTLeQAT.ANNDVQI
  14 AAEPASCSTVRFSDV.GWTDITSTTAVATEILK.GLGYTTD.-IKVLSVPVTY.ASL.AKKDIDV
  15 -GMADKGETVNIAYV.QWDSEVASTHVIAEVLK.NEGYHVT.-LTPLDNAVMW.QTV.ANGNADF
  16 -GMADKGETVNIAYV.QWDSEVASTHVIAEVLK.NEGYHVT.-LTPLDNAVMW.QTV.ANGNADF
  17 -GYCSAGKTITFAGI.DWESGSFITEVMKEILS.K-GYDCK.VDSIPGNSVTLeQAT.ANNDVQI
  18 -GYCSAGKTITFAGI.DWESGSFITEVMKEILS.K-GYDCK.VDSIPGNSVTLeQAT.ANNDVQI
  19 ADAAEYNQPVEIGYV.LWDGEIASTNVIQQVLQ.QAGYTDV.EIIAVDAGPLY.QGV.ASGEFDF
  20 AEKPGDGVKVTPIFP.SIAEERFRGEVAMEGLR.ELGYKVQ.EPKETEYGVMM.VAL.ANGDADF
  21 AADDAACRTIRLSDP.GWTDITATNGVASVLLD.ALGYEAD.-VKTLSVPIGY.QAM.KNGEIDV
  22 AADADACKMVRMAEP.GWNDLAFTTGIAMTLLK.SLHYQPQ.-SQLLGIDVIY.TSL.KSKDLDV
  23 AADDAACRTIRLSDP.GWTDITATNGVASVLLD.ALGYEAD.-VKTLSVPIGY.QAM.KNGEIDV
  24 AADADACKMVRMAEP.GWNDLAFTTGIAMTLLK.SLHYQPQ.-SQLLGIDVIY.TSL.KSKDLDV
  25 AGDAESCKTVRLSDV.GWTDIQATTGLASVLLT.ALGYEPK.-VIQLSVPVTM.ASL.KNKDLDV
  26 FGKKSSDKKVDLVYM.NWDSEVASINVLTQAME.EHSFDVT.-TTALDNAVAW.QTV.ANSQADG
  27 AAYAADCGNVTIASM.NWQSAEVAANLDKFILE.K-GYGCSaEIVTGDTVPTL.TSMaEKGQPDI
  28 VGADSGGQTVTLATV.NWESEIASTNVLAQVLK.EAGFNVQ.-ITTVDPAIMF.SSV.AEGQLDA
  29 FGKTASDKKVDLVYM.NWDSEVASINVLTQAMK.EHGFDVK.-TTALDNAVAW.QTV.ANGQADG
  30 ANAAETCGNITIAEM.NWASAGVAAYVDKFIME.N-GYDCTvNVISGDTTPTF.TSMnEKGQPDM
  31 ----ELSEPVTIGYV.LWDGEIASTNVIQQVLE.QAGYEDV.EIVAVDAGPLY.QGL.ADGQFDF
  32 AAECPYPGKVVFAGL.NWESGMFTTDLLRYVLE.K-GYGCE.TDALPGNTVTMeNAL.RQNDIQV
  33 -AFAEECGDVVIANM.NWQSIDVLANIDKIILE.N-GYGCSaEITIGDTVSIM.TSMiEKGEPDI
  34 -AEDPACARVRLADP.GWSDIAVTNATAAFLLE.SLGYQVK.-IDTLSVPIIY.GGL.RDGQVDA
  35 FALGATKPGLKIGYVeGWDDSVATTNVAARIIEkKLGYPVQ.-LVPVAAGVMW.QGV.ARGDLDA
  36 ---------------.--------------LLK.SLGYETD.-VKLLSVPVTY.TSL.KNKDIDV
  37 AELPGDGKTIRFAQSdSLGANYVVAKIVTKGFE.ALGYKVK.-LSTVNTTLFF.QAV.AQGDLDI
  38 MAAAADKPVITIGYVdGWSDSVATTHVAAEVIReKLGYEVK.-LMPVAAGIMW.QGV.ARGKLDA
  39 -------KSVKIGYV.NWGGETAATNVLKVVFE.KMGYNAE.-IFSVTTSIMY.QYL.ASGKIDG
  40 -GWCESGKAVKFAGL.NWESGTLLTELMQFVLA.K-GYGCT.TDSLPGNSITMeQAL.STNDIQV
  41 FSAKAEEKTITVGTM.SWEDLTPITGITKKVLE.DSGYTVK.VVSFSEWGIAY.AAL.SKGDIQL
  42 FSAKAEEKTITVGTM.SWEDLTPITGITKKVLE.DSGYTVK.VVSFSEWGIAY.AAL.SKGDIQL
  43 AAFAQDGKTVKIGWA.PWSDAEFVTKLARKLIEdNLGQKVE.-LVQTDVAPLY.QGV.SRGDIDA
  44 ---VGDGKKVSIGYI.PWDEGVASTFLWKEILE.QRGFEVE.-AKQFEAGPLY.TAL.AQGNIDF
  45 -GIRTHAADLVIAMP.NWSSGQATANILKVGLKkEFGLDAE.-VVEMGTMIAF.AGL.DSGQVDI
  46 --PAEAKQPLDVAWF.PWEEDVAVTYLWKNVLE.RRGYKMN.-LKQMDVGPVY.TGL.ASGGIDL
  47 AAAPESNDPIKIALF.DWTSVNLNAKILGGILE.KLGYTVE.YPTADYLSSLT.TGL.TNGDLDV
  48 VAAPAAAADLVIAMP.PWPSGQAAANILKLGIAkKFSLEAE.-VRELGTLTAF.IGL.EKGEVDI
  49 ---AAECGDVSIAEM.DWASAGVAAHVDRFILE.N-GYGCSvKLVAGDTMLTF.TSMnEKAEPDL
  50 YANAQGARTVTLSVQ.SWVGAQANVAVAQYLLEhELGYRVD.-TVQVDEVPAW.DAL.SQGRVDA
  51 -TNANSKGKIKLGVT.SWKENIATANMWKVLLE.QKGYKVE.-LMYLEKAAIW.TGV.ARGDVDA
  52 ---------------.-----------------.-------.-----------.---.-------
  53 ---------------.-----------------.-------.-----------.---.-------
  54 ---------------.-----------------.-------.-----------.---.-------
  55 ---------------.-----------------.-------.-----------.---.-------
  56 ---------------.-----------------.-------.-----------.---.-------
  57 -AFASECSSVRFAEV.GWTDITVTTALASEVLE.ALGYEPR.-VDTVSVPIAY.AGI.RNNDFDV
  58 -----KGDKINLAYV.AWDSEIASTNVIGKVLE.DLGYEVT.-LTQVEAGPMW.TAI.ATGSADA
  59 -----DGDEIKLTYV.AWDSEIASTNVVAEALK.QVGYKPT.-IQAMEIQPMW.ASV.ATDAADG
  60 -----DGDEIKLTYV.AWDSEIASTNVVAEALK.QVGYKPT.-IQAMEIQPMW.ASV.ATDAADG
  61 -----DGDEIKLTYV.AWDSEIASTNVVAEALK.QVGYKPT.-IQAMEIQPMW.ASV.ATDAADG


              70        80         90       100             110       1
              |         |          |         |               |        
   1 TAVNWTPLHDNMYEAAGGDKKFYREGVFV.NGAAQGYLIDKKT.....AD.QYKITNIAQLKDPK
   2 TAVNWTPLHDNMYEAAGGDKKFYREGVFV.NGAAQGYLIDKKT.....AD.QYKITNIAQLKDPK
   3 TAVXWTPLHDNMYEAAGGDKKFYREXVFV.NGAAQGYLIDKKT.....AD.QYKITNIAQLKDPK
   4 TAVNWQPLHDDMYAAAGGDKKFYREGVFV.SGAAQGYLIDKKT.....AE.QYNITNIAQLKDPK
   5 TAVNWQPLHDDMYAAAGGDNKFYREGVFV.SGAAQGYLIDKKT.....AE.QYNITNIAQLKDPK
   6 FLGNWMPTMTNDIKQYAEKGTVETLRANL.EGAKYTLAVPQYV.....YD.G-GLRSFADIAKFS
   7 YLGDWQPSMEADRKPFLEDKSIEVIGPNL.TGAKYTFAVPKYV.....AD.A-GVKDISDLQKFP
   8 LAVNWVPLHNDQYNAAGGDAKFYRQGNYI.EGLAQGYLIDKKT.....AD.QYNITNVAQLKDPK
   9 FLGNWMPTMEGDIAPYRDDKSVETLRENL.TGAKYTLATNAKG.....AE.L-GIKDFKDIAAHS
  10 FAEEWLG-RSDVWNKAVEEKKVIAVGKTF.VGASEGWFVPDYVv10ieAK.APDLKSVSQLTDPK
  11 FLGNWMPTMEADIAPYREDKSVETVRENL.AGAKYTLATNAKG.....AE.L-GIKDFKDIAAHK
  12 FLGNWMPTMEADIAPYREDKSVETVRENL.AGAKYTLATNAKG.....AE.L-GIKDFKDIAAHK
  13 FAEEWLG-RSDVWNKAVEEKKVIAVGKTF.VGASEGWFVPDYVv10ieAK.APDLKSVSQLTDPK
  14 FLGYWNPSMSADLQPYLDNKTVETLRTNL.TGAKYTLAVPQFV.....FD.E-GLKDFKDIAKFK
  15 STSAWLPVTHGQQYQKYKS-KLDDLGPNL.KGTKLGLAVPKYM.....T-.--DVNSIEDLSKQA
  16 STSAWLPVTHGQQYQKYKS-KLDDLGPNL.KGTKLGLAVPKYM.....T-.--DVNSIEDLSKQA
  17 FAEEWIG-RSDVWNKAAEAGQVKSVGKTF.VGAAEGWFVPEYLv10iaAK.APDLKSVDQLSDPK
  18 FAEEWIG-RSDVWNKAAEAGQVKSVGKTF.VGAAEGWFVPEYLv10iaAK.APDLKSVDQLSDPK
  19 TTSAWLPQTQANYWETYGD-RIDSVRVNL.EDCTIGLAVPTYV.....E-.--EVNSIEDLNDNK
  20 TVHLWDKLHNQFYQQAGGDDVMVKTGDIL.PGVAQGYLIDKKT.....AD.QYNIKYITDLKKPE
  21 FLGNWMPAQKSFVDDLNAAKAAEVMTKNL.EGAKFTLAVPAYM.....AE.K-GVKDFADLAKHA
  22 FMGYWDPAMVNYYKPYKEDGSVEKVRTNL.VGAKYTFAVPTYV.....WE.A-GVKDFSDLQKFA
  23 FLGNWMPAQKSFVDDLNAAKAAEVMTKNL.EGAKFTLAVPAYM.....AE.K-GVKDFADLAKHA
  24 FMGYWDPAMVNYYKPYKEDGSVEKVRTNL.VGAKYTFAVPTYV.....WE.A-GVKDFSDLQKFA
  25 FLGNWMPSMTNDIKDYTADGSVETISTNL.TGAGYGIVVPTYV.....AD.A-GVKSLTDLGKFK
  26 MVSAWLPNTHKTQWKKYGK-SVELLGPNL.KGAKVGFVVPSYM.....--.--NVNSIEDLTNQA
  27 APEAWVSLQPEIVKHGLEGGKVVAAAKILsDGAVQGWWIPKYL.....ADaNPDLKTIPDLFKHP
  28 MVGGWVPTTHQAYAEKYGD-SMVDLGANL.EGAISALTVPTYM.....E-.--DINSITDLTDEN
  29 MVSAWLPNTHKTQWQKYGK-SVDLLGPNL.KGAKVGFVVPSYM.....--.--NVNSIEDLTNQA
  30 APEMWVNTLGTPYEEAVKKGNLIQEVKILsEGGVEGWWIPKYL.....ADeHPDIKTVEDALKHP
  31 TTSAWLPYTHQSYWEAYGD-QLDSVQTNL.EDCKIGLVVPSYV.....--.--TIDSIEELNSEK
  32 TGEQWAG-RSPVWRAAEEAGEVFSVGETV.KGATEGWWVPEYLv10ieAK.APELRSVADLPRYK
  33 APEAWLNALPEIVSRGIAEGKLISAGNALsDGGIQGWYIPKYI.....ADaHPEIKTVSDALKHP
  34 FLGGWMPAHQDYHDKFVASGQVERLGRNL.DGTRFTLAVPRYV.....WD.A-GVHRFEDLAAQG
  35 TLSAWLPVTQGAYWDQFKT-KVVDLGPNF.TEARIGLIVPESA.....--.--GAKTIEDLNAQK
  36 FLGNWMPTMEGDIAPYRDDKSVETLRENL.TGAKYTLATNAKG.....AE.L-GIKDFKDIAAHS
  37 ATDINFPQREPGFRKVADKADMIGKGLIE.GGGINGYLIDKKT.....AD.AYNIKTLDQMKDPK
  38 MLSAWLPGTHGAYYEKMKD-KVVNLAINY.PDARIGLIVPEYV.....--.--SANSIADLQAQK
  39 TVSSWVPTADKFYYEKLKT-KFVDLGANY.EGTIQGFVVPSYV.....--.--PISSISELKGKG
  40 FAEEWIG-RSDAWNKAAAAGKVVGVGEPI.VGAVEGWYVPRYVi10leAK.APKLRSIADLAQYA
  41 LASQTDYVAQDYWDKNKR--RLEKISPVS.HGLYQAIAVPKYV.....--.--TIDSMDQLNDNA
  42 LASQTDYVAQDYWDKNKR--RLEKISPVS.HGLYQAIAVPKYV.....--.--TIDSMDQLNDNA
  43 MMMAWLPETHADYYKRVEG-KVENLGPLY.EGAKLGWIVPDYI.....PE.S-EVSSIEDLKKPE
  44 QTDSWLPTTHEQYWKKYGK-QLEDLGSWY.DETSLELTVPAYM.....K-.--DINSLEDLKGKA
  45 HPEVWLPNLDTLVKKYVTQAGTVAISPIG.VPAWQGICANRTA.....AD.KYGFKDISDLSDPK
  46 NFDAWLPYAQSNYWNKHKD-NLVDLGTWY.EPTSLEIAVPSYV.....K-.--DVKSLADLKGKS
  47 GLEFWDTTAGEAMKASDATGQTERLGKLG.PKAKEEWWFPEYM.....KEkCPTLPDWHALLDPT
  48 QPEVWRPNFDELVRKFVTEKGVVTLSERA.VPAWQGICATPEA.....AA.--TIKSVADLGDPA
  49 VPELWINSVRTPFDAAVKEGRLVEGAKILsEGGVEGWWIPKFI.....ADaHPDIRTVQDALKHP
  50 ILEDWG--HPEQEQRYVQDKKTIAPGGDLgVTGHIGWFVPTYF.....AKkHPDVTNWKNLNKYA
  51 NLEVWLPVTDKPLNDRYKD-DIVLKSKWY.EGTGLGLVVPSYM.....K-.--NISSIEDLNAHK
  52 -----------------------------.-------------.....--.--------------
  53 -----------------------------.-------------.....--.--------------
  54 -----------------------------.-------------.....--.--------------
  55 -----------------------------.-------------.....--.--------------
  56 -----------------------------.-------------.....--.--------------
  57 FLGNWMPSMASISDPYIERGEVERLVANL.EGAKYTLAVPQYV.....YD.A-GVTSVNDLAEHA
  58 SLSAWLPNTHKAYAAKYKG-KYDDIGTSM.TGVKMGLVVPQYM.....K-.--NVNSIEDLK---
  59 MVAAWLPNTSGIYYKDYKG-KFEDLGPNL.KGAKIGLAVPKYM.....T-.--NINSIEDLK---
  60 MVAAWLPNTSGIYYKDYKG-NFEDLGPNL.KGAKIGLAVPKYM.....T-.--NINSIEDLK---
  61 MVAAWLPNTSGIYYKDYKG-KFEDLGPNL.KGAKIGLAVPKYM.....T-.--NINSIEDL----


      20         130       140        150         160        170       
      |           |         |          |           |          |       
   1 IAKLF.DT.NGDGKADLTGCNPGWGCEGAI.NHQLAAYELT..NTVT.HNQGNYAAMMADTISRY
   2 IAKLF.DT.NGDGKADLTGCNPGWGCEGAI.NHQLAAYELT..NTVT.HNQGNYAAMMADTISRY
   3 IAKLF.DT.NGDGKADLTGCNPGWGCEGAI.NHQLAAYELT..NTVT.HNQGNYAAMMADTISRY
   4 IAKIF.DT.NGDGKADMMGCSPGWGCEAVI.NHQNKAFDLQ..KTVE.VSHGNYAAMMADTITRF
   5 IAKIF.DT.NGDGKADMMGCSPGWGCEAVI.NHQNKAFDLQ..KTVE.VSHGNYAAMMADTITRF
   6 -----.--.-DKLGNKIYGIEPGNDGNRVA.QSMIDKNAFEl.GKFK.LVESSEAGMLSQVQRAI
   7 -----.--.-DKFGRKIYGIEPGNNGNRMI.LDMINKGDFGl.TGWE.LVESSEQGMLAEVERAT
   8 IAKLF.DA.NNDGKADLTGCNPGWGCEAPI.NHQIKAYGLS..DTVT.HNQGNYAAMIADTITRY
   9 -----.--.-SELGGKIYGIEPGNDGNRLI.LDMVAKDSFGl.KSFE.VVESSEQGMLSQVARAE
  10 IAEIFaDP.EEPSKGRFLNCPSGWTCEGVS.TAKLEAYKLGe.TYVN.FRPGTGTALDAAITSAY
  11 -----.--.-DELDGKIYGIEPGNDGNRLI.IDMVEKGTFDl.KGFE.VVESSEQGMLAQVARAE
  12 -----.--.-DELDGKIYGIEPGNDGNRLI.IDMVEKGTFDl.KGFE.VVESSEQGMLAQVARAE
  13 IAEIFaDP.EEPSKGRFLNCPSGWTCEGVS.TAKLEAYKLGe.TYVN.FRPGTGTALDAAITSAY
  14 -----.--.-DKLGGKIYGIEPGNDGNRLI.LSMINKNAFGl.KSFE.LAESSEQGMLAQVARSI
  15 -----.--.----DQKITGIEPGAGIMAAA.QKTLKEYHNL..SSWE.LVAASTGAMTTSLDQAI
  16 -----.--.----DQKITGIEPGAGIMAAA.KKTLKEYHNL..SSWE.LVAASTGAMTTSLDQAI
  17 IVELFrDP.EEPTKGRFLNCPSGWTCEGVN.TAKLQAYKLDg.NYVN.FRPGTGTALDAAIAAGY
  18 IVELFrDP.EEPTKGRFLNCPSGWTCEGVN.TAKLQAYKLDg.NYVN.FRPGTGTALDAAIAAGY
  19 -----.--.-EMFNGEIIGIDPGAGVMQIT.EDVIEAYDLD..--YT.LVSSSSAGMTAALQRAI
  20 IAKLF.DT.DGDGKADMTGCNPGWGCELVI.AHHMKAYDLD..KSIT.VNQGSYFALMADTITRY
  21 -----.--.-DEFESKIYGIEPGAPANQNI.QKIIDANDFGl.KGWQ.LVESGEQAMLAQVERAG
  22 -----.--.-DKFDRKLYGIEPGS--NQLM.LDAVKDPALGl.KDWE.VVESSEQGMLSQVARFN
  23 -----.--.-DEFESKIYGIEPGAPANQNI.QKIIDANDFGl.KGWQ.LVESGEQAMLAQVERAG
  24 -----.--.-DKFDRKLYGIEPGS--NQLM.LDAVKDPALGl.KDWE.VVESSEQGMLSQVARFN
  25 -----.--.-DKFNGKIYGIEAGNDGNRII.LDMIKNPKDNl.EGFE.LVESSEAGMLTQAEQSM
  26 -----.--.----NKTITGIEPGAGVMAAS.ENTLKSYSNL..KDWK.LVPSSSGAMTVALGEAI
  27 -ELFP.AP.EDKSKGAVFNGPQGWGGTVVT.AQLFKAFGGEkaGFTL.VDTGSAAGLDGSIAKAY
  28 -----.--.----DSTITAIEPGAGVTNSA.QNAVKEYDNL..SDWE.VSVSSTGAMIAELDQAI
  29 -----.--.----NKTITGIEPGAGVMAAS.EKTLNSYDNL..KDWK.LVPSSSGAMTVALGEAI
  30 -ELFP.AP.EDASKGAVFGCPPGWGCQPTT.ANLFKARKADekGFAL.IDTGSAAGLDGSISNAY
  31 -----.--.-DKFNGQIIGIDPGAGIMQAS.ETAITDYDLD..--ME.LVSGSSAAMTTSLKKSI
  32 -ALFR.DP.EEPAKGRFYNCPTGWTCEIVN.SQKLKAYRLQ..DSYTnFRTGTGPALDAAISAAF
  33 -ELFP.AP.EDSSKGAVVNGPSGWGASTTT.SQLYKAYDGDakGFVL.VDPGSAAGLDGSIVKNY
  34 -----.--.-QRFNRKLYGIGSGAPANQSI.QKMIDANQFGl.GDWK.LVESSEQAMLAELGRAE
  35 -----.--.-SAFEGRIVGIDAGAGVMRKA.GDAIKSYGLN..--YS.LMPSSGSAMTAELARSM
  36 -----.--.-SELGGKIYGIEPGNDGNRLI.LDMVAKDSFGl.KSFE.VVESSEQGMLSQVARAE
  37 IAALF.GT.DG--KADLINCDPGWSCGDVV.EYQLDKFGLK..DTVK.SVRGKYEALMVEAVARA
  38 -----.--.-DAFGGRVVGIDAGAGVMIKT.DEAIKQYGLD..--YK.LVASSGSGMIAELTRAE
  39 -----.--.-DKFKNKMIGIDAGAGTQIVT.EQALNYYGLS..KEYE.LVPSSESVMLASLDSSI
  40 -EVFR.DP.EEPGKGRFYNCPAGWTCELEN.SEMLKSYGLEe.TFTN.FRPGTGPALDAAVLSSY
  41 -----.--.-DKFGGKIIGIEPGSGLMRDA.GKAAKDYGLK..--LQ.LVEGSTAAMTAALKSAI
  42 -----.--.-DKFGGKIIGIEPGSGLMRDA.GKAAKDYGLK..--LQ.LVEGSTAAMTAALKSAI
  43 VR---.--.-EKLKGEIQGIDPGAGLTRLS.QEAIKKYGLD..--YK.LNISSEAAMLTTVDRAN
  44 -----.--.-DLFGGKITGIEPSAGEMNLLkTKVLKEYGLD..KEYK.VVDSSTPAMLAELKRAY
  45 KTEAL.DT.DGDGKGEMWIGAQTWSSTTIE.RIRANSYGYA..RNLT.LLEMPEDVGMAAVDAAE
  46 -----.--.-DLFDGKIIGIEPGTGEMQLLkNDVLPGYGLE..DEYE.VVDGSTPAMLAELKRAL
  47 CAASF.STaETSPKGRYLGGPVTW--EGFD.DERVAALKLP..-FTV.IHAGTDAAMFAELDSAY
  48 KTKIL.DT.DGDGRGEMWIGAAEWLSTGIE.RARAAGYGYA..ANLT.LVEAKEEVAMAAVDAAI
  49 -ELFP.SH.ENPAKGAIHNCPSSWNCRFST.ANLYKALDAEkaGFQL.IDPGSAAGLDASITEAF
  50 -DLLR.TA.ESGGKGQLLDGSPSY--VTND.KALVKNLDLD..-YQV.VFAGSEAAQITQMQQFA
  51 -----.--.-DELDNKIVGIEPGSSLMNLT.NKAMKEYDIK..--LK.LVQSSEAALMSELKKAY
  52 -----.--.-EQVNKTIIGIDPGSGIMSLT.DKAMKDYDLN..-DWT.LISASSAAMTATLKKSY
  53 -----.DL.GEQINYTITGIDAGAGIMLAT.QNAIKDYHLDd.DNWQ.LQTSSTAAMTSTLQKAM
  54 -----.DL.GEQINYTITGIDAGAGIMLAT.QNAIKDYHLDd.DNWQ.LQTSSTAAMTSTLQKAM
  55 -----.DL.GEQINYTITGIDAGAGIMLAT.QNAIKDYHLDd.DNWQ.LQTSSTAAMTSTLQKAM
  56 -----.--.--------------------A.NKALKSYSNL..SDWK.LVSASTGAMTTALDQAY
  57 -----.--.-DQFEQRIHGIEAGND-----.----------..----.-----------------
  58 -----.--.---------------------.----------..----.-----------------
  59 -----.--.---------------------.----------..----.-----------------
  60 -----.--.---------------------.----------..----.-----------------
  61 -----.--.---------------------.----------..----.-----------------


      180       190       200       210             220            230 
       |         |         |         |               |              | 
   1 KEGKPVFYYTWTPYWVSNELKPGKDVVWLQVPFSALPGDK.....NA.DT...KLPNGA..NYGF
   2 KEGKPVFYYTWTPYWVSNELKPGKDVVWLQVPFSALPGDK.....NA.DT...KLPNGA..NYGF
   3 KEGKPVFYYTWTPYWVSNELKPGKDVVWLQVPFSALPGDK.....NA.DT...KLPNGA..NYGF
   4 KEGKPVLYYTWTPYWVSDVMKPGKDVVWLQVPFSSLPGEQk....NI.DT...KLPNGA..NYGF
   5 KEGKPVLYYTWTPYWVSDVMKPGKDVVWLQVPFSSLPGEQk....NI.DT...KLPNGA..NYGF
   6 RRNQWVVFLGWEPHPMNTRFQ----MKYLEGGDDFFGP--.....--.--...------..--NY
   7 KDDQWIVFLGWAPHPMNTRYQ----IDYLSGADAYFGP--.....--.--...------..--NY
   8 KEGKPILYYTWTPYWVSDVLVPGRDVVWLQVPFSSLPD-K.....TI.DT...QLSNGA..NYGF
   9 KSGEPIVFLGWEPHPMNANFK----LTYLTGGDEVFGP--.....--.--...------..--NF
  10 LQGEPILFYYWSPTAILGKFK----LIQLEEPAYNEACWK.....ELsSA...NGKRDE..GCAF
  11 KSGDPIVFLGWEPHPMNANFK----LTYLSGGDDVFGP--.....--.--...------..--NY
  12 KSGDPIVFLGWEPHPMNANFK----LTYLSGGDDVFGP--.....--.--...------..--NY
  13 LQGEPIFFYYWSPTAILGKFK----LIQLEEPAYNEACWK.....ELsSA...NGKRDE..GCAF
  14 KSKEPIVFLAWEPHPMNKRFK----IAYLTGGDDFFGP--.....--.--...------..--NL
  15 KKKDPIVVTAWSPHWMFAKYD----LKYLKDPKEIFGS--.....--.--...------..----
  16 KKKDPIVVTAWSPHWMFAKYD----LKYLKDPKETFGS--.....--.--...------..----
  17 LQGEPMLFYYWSPTAIMGKYK----LIQLQEPAYSESCWK.....ELtSA...DGKRDA..GCAF
  18 LQGEPMLFYYWSPTAIMGKYK----LIQLQEPAYSESCWK.....ELtSA...DGKRDA..GCAF
  19 NNEEPVVVTLWSPHWAFNRWD----LKYLDDPQGYYGE--.....--.--...------..----
  20 KEGKPVFYFTWVPQWIASVLVEGKDVVWLEVPKTDLPDGK.....ND.VD...TTYHGK..NLGF
  21 RDKKAVVFLAWAPHPMNEKID----IAYLSGGDAYFGP--.....--.--...------..--NF
  22 RNKTFIVFQGWAPHPMNAKFD----IKYLTGGDKFYGP--.....--.--...------..--DF
  23 RDKKAVVFLAWAPHPMNEKID----IAYLSGGDAYFGP--.....--.--...------..--NF
  24 RNKTFIVFQGWAPHPMNAKFD----IKYLTGGDKFYGP--.....--.--...------..--DF
  25 KNNEWIAFLGWTPHPVMGAMK----ITYLDGMGDS-----.....--.--...------..--GF
  26 KQHKDIVITGWSPHWIFNKYD----LKYLADPKGTMGT--.....--.--...------..----
  27 EAKQPWVGYYWAPTSLLGKYE----MVKLGFGTEYDAAEW.....KR.CTsvaDCPDPK..PNAW
  28 NNEEDIVVVGWKPHWMFMDYD----LKMLDDPENVFGG--.....--.--...------..----
  29 KQHKDIVITGWSPHWMFNKYD----LKYLADPKGTMGT--.....--.--...------..----
  30 EKKQGWLGYYWSPTAILGKYD----MVKLDDGVALDREAY.....DT.CIakpDCADPK..PNAY
  31 DSEEWTVVTLWSPHWAFNRWD----LKYLDDPKGAYGD--.....--.--...------..----
  32 RRGEPVLFYYWSPTPLMGRFK----LVQLEEPPFSEKAWA.....TLsDP...KNPDPI..GSRS
  33 ERKIGWFGYYWSPTSLLGKYP----MVKLDFDAPHNAAEWkrc..NT.VV...DCEDPT..VNDW
  34 KRQRWLVFLGWTPHPMNIRHD----LRYLEGGEQYFGD--.....--.--...------..----
  35 NANKPIVVTGWAPHWMFAKWK----LRFLEDPKKVFGD--.....--.--...------..----
  36 KSGEPIVFLGWEPHPMNANFK----LTYLTGGDEVFGP--.....--.--...------..--NF
  37 KRGEPVFFYAWSPSWMNKALQPGKDVVWLPTPFDALPPSVp11nvEG.CA...GAANPC..RMAM
  38 NEKKPVVVTGWIPHWMFAKWK----LKFLDDPKKVYGD--.....--.--...------..----
  39 KRNEWILVPLWKPHWAFSRYD----IKFLDDPDLIMGG--.....--.--...------..----
  40 RRGEPILFYYWSPTPLMGRAG----LVRLEERPGVDKR--.....--.--...------..----
  41 DRKEWVAVTVWEPSWMMQRYD----VKFLKDPKGVFPP--.....--.--...------..----
  42 DRKEWVAVTVWEPSWMMQRYD----VKFLKDPKGVFPP--.....--.--...------..----
  43 RSEGWFVATSWSPHWMFGKYK----LRYIADPKGALGG--.....--.--...------..----
  44 SKQEPIVTTLWSPHWAYNDYK----LKKLKDPKGAWGK--.....--.--...------..----
  45 ASDRPMVFACYAPHVVFKLHD----IVRLTEPPYDAAKWKiv6teDP.QW...LAKSQA..AVGW
  46 AKKEPVAVTLWSPHWAYSDYE----LTKLKDPKKAFGE--.....--.--...------..----
  47 QRKAPIMLWIYSPHWAPAKYK----GEWVQFPEYTPECYN.....DP.KW...GVNPDAkyDCGK
  48 ATARPMVFYCYAPHHVFKLHQ----ISRLEEPPHDPAKWKiappnDP.LW...VSKSSA..ATAW
  49 EKKTGWLGYYWAPTALLGKYE----MTLLSFGVDHDKAEW.....DS.CTaapDCPTPK..VNSY
  50 KERKPFLSYWYTPQWLMEKVP----MTEVKLPPYEEGC--.....--.-D...ADPEKV..ACAY
  51 TKKKPIAVTLW-----------------------------.....--.--...------..----
  52 DRKKPIIITGWTPHWMFSRYK----LKYLDDPKQSYGS--.....--.--...------..----
  53 KDKRPIVVTGWTPHWMFTKFD----LKFLDDPKNVFGN--.....--.--...------..----
  54 KDKRPIVVTGWTPHWMFTKFD----LKFLDDPKNVYGN--.....--.--...------..----
  55 KDKRPIVVTGWTPHWMFTKFD----LKFLDDPKNVYGN--.....--.--...------..----
  56 KNKKDIVVAAWSPHWMFAKYK----LKYLKDSKKDFGS--.....--.--...------..----
  57 ----------------------------------------.....--.--...------..----
  58 ----------------------------------------.....--.--...------..----
  59 ----------------------------------------.....--.--...------..----
  60 ----------------------------------------.....--.--...------..----
  61 ----------------------------------------.....--.--...------..----


            240       250       260        270       280       290     
             |         |         |          |         |         |     
   1 PVSTMHIVANKAWAEKNPAAAKLFAIMQL.PVADINAQNAIMHAGAASEGDIQGHVDGWIKAHQQ
   2 PVSTMHIVANKAWAEKNPAAAKLFAIMQL.PVADINAQNAIMHDGKASEGDIQGHVDGWIKAHQQ
   3 PVSTMHIVANKAWAEKNPAAAKLFAIMQL.PVADINAQNAIMHDGKASEGDIQGHVDGWIKAHQQ
   4 PVNTMHIVANKAWAEKNPAAAKLFAIMKL.PLADINAQNAMMHAGKSSEADVQGHVDGWINAHQQ
   5 PVNTMHIVANKAWAEKNPAAAKLFAIMKL.PLADINAQNAMMHAGKSSEADVQGHVDGWINAHQQ
   6 GGATIYTNVRKGYAQECANVGQLLKNLSF.TLEMENKLMDAVLNEN---KKPEEAAKAWLKDHPE
   7 GGADIYTNIRAGYAQECPNVARFVTNLRF.TLEMENEIMNGILNDG---NDPKDAAADWLKAHPE
   8 PPSVMHIVANKKWAEANPAAAKLFSIMKL.SINDVNAQNMRMHSGESSDADIERHVNGWINAHQA
   9 GGATIYTNVRKGYVEECPNVGAFLKNLQF.SLPMENEIMGKILNDG---LEGEAAATAWLKANPA
  10 PSVDVAYGVNSTFASEAPEIVEILEKATF.PLDEVNASLAYMADNK---VDATAAAAEFLKTKGD
  11 GGATVHTNVRAGYTTECPNVGKLLQNLSF.SLQMENEIMGKILNDG---EDPEKAAAAWLKDNPQ
  12 GGATVHTNVRAGYTTECPNVGKLLQNLSF.SLQMENEIMGKILNDG---EDPEKAAAAWLKDNPQ
  13 PSVDVAYGVNSTFASEAPEIVEILEKATF.PLDEVNASLAYMADNK---VDATAAAAEFLKTKGD
  14 GGAKVETNVRTGYTQECPNVGKFLTNLEF.NLDMENDIMGKILDDG---EEPAKAATEWLKANPG
  15 -TENINTIARKGLKKELPNVYKIIDKFHW.TQKDMEAVMLDINKG----MSPEAAAKKWVEANKS
  16 -TENINTIARKGLKKELPNVYKIIDKFHW.TQKDMEAVMLDINKG----MSPEAAAKKWVEANKS
  17 PSVEVAYGVNSTFAKDAPEIIAILEKATF.PLAEINASLAYMTDKQ---VDATAAAKTFLQTKAD
  18 PSVEVAYGVNSTFAKDAPEIIAILEKATF.PLAEINASLAYMTDKQ---VDATAAAKTFLQTKAD
  19 -ADNVETLARQGLEEDMPNLYGILERFAW.THEDIQSVMVDIESG----MAPEEAAAKWVENNPE
  20 AIDKVVAVLNKDFAEKNPAAVKFLSQVQI.STADESNQNLKMQQGEKKPKDIERHAKEWVAAHRQ
  21 GGAEVYTLARTGWPQQCPNAATLFKNLKF.DIGMENSLMGSILGGE----DSKAAAAAWLKANPK
  22 GAATVDTQVRRGYLQECPNVAKLLQNLEF.DVEFENKGMDLIMNGG---LSPEDAAAQAIKAEPH
  23 GGAEVYTLARTGWPQQCPNAATLFKNLKF.DIGMENSLMGSILGGE----DSKAAAAAWLKANPK
  24 GAATVDTQVRRGYLQECPNVAKLLQNLEF.DVEFENKGMDLIMNGG---LSPEDAAAQAIKAEPH
  25 GAATVFTNVRKGYTTECPNAGKFIANLKF.NLDMEGQMMDAILKG----ADAQTVATDWLKKNPD
  26 -SENINTIVRKGLKKENPEAYKVLNNFNW.TTKDMESVMLDIQNGK----TPEAAAKAWIKDHQK
  27 QVDDVQTLVSKSFADRAGPAMDYLNKRAW.TNATVNKLIAWMTDNQ---ATGEDGAKQFLKENEA
  28 -YEEIHSYAREGLKEDNPEAYKIIDNFYW.EVEDMSSVMEELATD----VEPEEAADNWIEANRE
  29 -SENINTIVRKGLKKENPEAYKVLDKFNW.TTKDMEAVMLDIQNGK----TPEEAAKNWIKDHQK
  30 PVAEVFTVVTKDFAEKAGPSIDYIRKRQW.DNATVAGVLAWMDDNQ---GTNEDGAEYFLENHED
  31 -ADHVETLARLGLEEEKPNLYGILTRFQW.THDDIQTVMMDIENG----TAPEEAAANWVANNPE
  32 LPAKITVGVSRDFHDKAPALVELFRKVEI.PLPLFNELLADMAQNH---REVGEVRAQFLRQHRE
  33 PTDKVETLVTREFKERAGAAMDYLKTRRW.DNATLNSLLAWMTDNQ---ATGEDAARYFLEKNPE
  34 -RGQVYTLARKGYAAQCPNPARLLANLRF.DLDMENRLMSDALEGT---ATPASATRAWLKANPR
  35 -SEHVDNVVNPGLETKAKPVVTFLKKFQW.KPGEIDSVMLAIQNG----TKPDAAADAWIAAHAD
  36 GGATIYTNVRKGYVEECPNVGAFLKNLQF.SLPMENEIMGKILNDG---LEGEAAATAWLKANPA
  37 AAWNWTAVGNKEFLKENPEVKSFVENMSF.PLSTWSSWEQAISQKGGSDATVRGLSDAWLSENKA
  38 -TEHVDTVANPALEAKAKPVWEFLKKFGWkDGNEVGQVMLAIQEG----AKPEDAAKQWVAANPG
  39 -IESVHTLVRLGLENDDFDAYYVFDHFYW.SDDLILPLMDKNDKEP---GKEYRNAVEFVEKNKE
  40 --IRIQVGLSRTFHDQAPELVAVLEKVNL.PAELLNSDLARMAKDR---IDAARLAREFLKEHPE
  41 -PQSYYWIGQKGFSAEYPHAREVIASVYV.PLADITAINGAVNDGK----TMDQAVKEWTDSHAD
  42 -PQSYYWIGQKGFSAEYPHAREVIASVYV.PLADITAINGAVNDGK----TMDQAVKEWTDSHAD
  43 -AEHIDAVARKGFKEDNPKVAALLAKMSI.PINELEAAMFDAQET-----SYEKAVDKYIADHPD
  44 -GDGVHSLSRKGFSGDNPVVAKWLKDFSM.TEKQLTSLEAEINKAG--KGQQQKAVRTWLEANPG
  45 DTAHYHIAYATSLRKKHPEVVRFLEHVDF.KPEEAIAMSYALQVER---QAPYAYAEQWVATNAA
  46 -GNTIRTISSKKFPEQYPQLTKWIKNFKM.SEDELGSLEAEIKDRG--QGQEEEAVAAWLKEHPD
  47 PHGEIWKYAWNGMKDKWPVAYKVAKAFTI.DTDELNKMSGDIDLNG---KTPEEVAAAWIAAHEA
  48 DAGQFQIGYATAFAKKHPEVAQFLQKVDF.SPDEVTAMSYALEVER---QAPADYARKWVESHAE
  49 PVSDVYTVVTKSFADRAGSAMDYVEARQW.ENATVNKVLAWMDQNQ---GTNESAARYFLGNFQE
  50 PVTPLQKYLNAGFAKDGGKAAEFLKRFTW.TTEDQNQVSLMIAQQK---MRPEEAAKKWVDGHES
  51 -----------------------------.-----------------------------------
  52 -AEEIHTITRKGFSKEQPNAAKLLSQFKW.TQDEMGEIMIKVEEGE----KPAKVAAEYVNKHKD
  53 -AENIHTIVRKGLKEEKPSAYKVLDNFFW.TAEDMSEVMLEVNDG----VDPEEAAKKWIKNNPE
  54 -AENIHTIVRKGLKEDKPSAYQVLDNFFW.TAEDMSEVMLEVNDG----VDPEEAAKKWIKNNPD
  55 -AENIHTIVRKGLKEDKPSAYQVLDNFFW.TAEDMSEVMLEVNDG----VDPEEAAKKWIKNNPD
  56 -IESIHSITRKGLKKDIPKANKIIDKFNW.TQKDMEAVMLDINNG----MSPEKAAKKWIKEHPK
  57 -----------------------------.-----------------------------------
  58 -----------------------------.-----------------------------------
  59 -----------------------------.-----------------------------------
  60 -----------------------------.-----------------------------------
  61 -----------------------------.-----------------------------------


        300         
         |         
   1 QFDGWVNEALAAQK
   2 QFDGWVNEALAAQK
   3 QFDGWVNEALAAQK
   4 QFDGWVKEALAAQK
   5 QFDGWVKEALAAQK
   6 QLDAWL--------
   7 AVAPWL--------
   8 TFDGWVKTA-----
   9 AIEPWF--------
  10 IWSKWVSDEARG--
  11 SIEPWLS-------
  12 SIEPWLS-------
  13 IWSKWVSDEARG--
  14 VLNQWL--------
  15 KVSSW---------
  16 KVSSW---------
  17 IWGGWVSADAKA--
  18 IWGGWVSADAKA--
  19 KVNEWIGEE-----
  20 QFDQWLQA------
  21 ALDGWLQ-------
  22 RLETWLKDVF----
  23 ALDGWLQ-------
  24 RLETWLKDVF----
  25 AVKPWI--------
  26 QVDKW---------
  27 LWKGWVSPEVA---
  28 IVDGWL--------
  29 EVDKW---------
  30 IWTKWVSPEVA---
  31 KVNEWIGE------
  32 IWSHWVPAEVAAR-
  33 IWTKWLSPEIA---
  34 VLEAWLQ-------
  35 RVNAWL--------
  36 AIEPWF--------
  37 LLDGWI--------
  38 RVKDWV--------
  39 IVKTWVPEKY----
  40 VWHAWVDEDA----
  41 LLKRW---------
  42 LLKRW---------
  43 RIKEWL--------
  44 VVD-----------
  45 RVEGW---------
  46 VV------------
  47 DWKAW---------
  48 RIDGW---------
  49 IWTQWVSPEVA---
  50 VWKKWL--------
  51 --------------
  52 QIAEW---------
  53 KVAKW---------
  54 KVAKW---------
  55 KVAKW---------
  56 KVASW---------
  57 --------------
  58 --------------
  59 --------------
  60 --------------
  61 --------------