Sequence numbers correspond to the following labels:

1. • T0156 Probable S-adenosylmethionine:2-demethylmenaquinone methyltransferase, Mycobacterium tuberculosis
2. • gi|15596969|ref|NP_250463.1|_5:153 (NC_002516) probable methyltransferase [Pseudomonas aeruginosa]
   • gi|17369015sp|Q9I2W7|MENG_PSEAE S-adenosylmethionine:2-demethylmenaquinone methyltransferase
   • gi|11351451|pir||B83423 probable methyltransferase PA1772 [imported] - Pseudomonas aeruginosa (strain PAO1)
   • gi|9947752|gb|AAG05161.1|AE004603_1 (AE004603) probable methyltransferase [Pseudomonas aeruginosa]
3. • gi|21233452|ref|NP_639369.1|_18:173 (NC_003902) acyl transferase [Xanthomonas campestris pv. campestris str. ATCC 33913]
   • gi|21115297|gb|AAM43251.1| (AE012524) acyl transferase [Xanthomonas campestris pv. campestris str. ATCC 33913]
4. • gi|17369593sp|Q9S4U0|MENG_PSEFL_6:154 S-adenosylmethionine:2-demethylmenaquinone methyltransferase
   • gi|5668608|gb|AAD45979.1| (AF115334) MenG [Pseudomonas fluorescens]
5. • gi|7573254|emb|CAB87566.1|_19:174 (AJ277295) FldZ protein [Sphingomonas sp. LB126]
6. • gi|19918963|dbj|BAB88738.1|_23:178 (AB073227) 4-carboxy-4-hydroxy-2-oxoadipate aldolase [Sphingomonas paucimobilis]
7. • gi|17549452|ref|NP_522792.1|_14:168 (NC_003296) PUTATIVE TRANSFERASE PROTEIN [Ralstonia solanacearum]
   • gi|17431705|emb|CAD18382.1| (AL646083) PUTATIVE TRANSFERASE PROTEIN [Ralstonia solanacearum]
8. • gi|15804520|ref|NP_290560.1|_2:152 (NC_002655) menaquinone biosynthesis, unknown [Escherichia coli O157:H7 EDL933]
   • gi|15834110|ref|NP_312883.1| (NC_002695) 2-demethylmenaquinone 2-C-methyltransferase [Escherichia coli O157:H7]
   • gi|16131767|ref|NP_418364.1| (NC_000913) menaquinone biosynthesis, unknown [Escherichia coli K12]
   • gi|418507sp|P32165|MENG_ECOLI S-adenosylmethionine:2-demethylmenaquinone methyltransferase
   • gi|541097|pir||S40872 2-demethylmenaquinone 2-C-methyltransferase (EC 2.1.1.-) menG [validated] - Escherichia coli
   • gi|305032|gb|AAB03061.1| (L19201) ORF_f161 [Escherichia coli]
   • gi|1336002|gb|AAB01208.1| (U56082) S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Escherichia coli]
   • gi|1790364|gb|AAC76911.1| (AE000467) menaquinone biosynthesis, unknown [Escherichia coli K12]
   • gi|12518832|gb|AAG59124.1|AE005623_15 (AE005623) menaquinone biosynthesis, unknown [Escherichia coli O157:H7 EDL933]
   • gi|13364332|dbj|BAB38279.1| (AP002567) 2-demethylmenaquinone 2-C-methyltransferase [Escherichia coli O157:H7]
9. • gi|15965518|ref|NP_385871.1|_18:173 (NC_003047) CONSERVED HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
   • gi|15074699|emb|CAC46344.1| (AL591788) CONSERVED HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
10. • gi|13242045|gb|AAK16525.1|AF331043_5_22:178 (AF331043) oxalocitramalate aldolase [Arthrobacter keyseri]
11. • gi|15232963|ref|NP_186926.1|_2:159 (NM_111145) putative S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Arabidopsis thaliana]
    • gi|17369187sp|Q9M8R9|MEG1_ARATH Putative S-adenosylmethionine:2-demethylmenaquinone methyltransferase 1
    • gi|6728985|gb|AAF26983.1|AC018363_28 (AC018363) putative S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Arabidopsis thaliana]
    • gi|21555774|gb|AAM63931.1| (AY086886) Putative S-adenosylmethionine:2-demethylmenaquinone methyltransferase 1 [Arabidopsis thaliana]
12. • gi|17546073|ref|NP_519475.1|_4:161 (NC_003295) PROBABLE S-ADENOSYLMETHIONINE:2-DEMETHYLMENAQUINONE METHYLTRANSFERASE PROTEIN [Ralstonia solanacearum]
    • gi|17428369|emb|CAD15056.1| (AL646064) PROBABLE S-ADENOSYLMETHIONINE:2-DEMETHYLMENAQUINONE METHYLTRANSFERASE PROTEIN [Ralstonia solanacearum]
13. • gi|18461241|dbj|BAB84438.1|_6:160 (AP003292) S-adenosylmethionine:2-demethylmenaquinone methyltransferase-like protein [Oryza sativa (japonica cultivar-group)]
    • gi|20160543|dbj|BAB89492.1| (AP003229) S-adenosylmethionine:2-demethylmenaquinone methyltransferase-like protein [Oryza sativa (japonica cultivar-group)]
14. • gi|15603033|ref|NP_246105.1|_2:152 (NC_002663) MenG [Pasteurella multocida]
    • gi|17368770sp|Q9CLP9|MENG_PASMU S-adenosylmethionine:2-demethylmenaquinone methyltransferase
    • gi|12721518|gb|AAK03252.1| (AE006157) MenG [Pasteurella multocida]
15. • gi|16762346|ref|NP_457963.1|_2:152 (NC_003198) menaquinone biosynthesis protein [Salmonella enterica subsp. enterica serovar Typhi]
    • gi|16767355|ref|NP_462970.1| (NC_003197) putative methyltransferase in menaquinone biosynthesis protein [Salmonella typhimurium LT2]
    • gi|21362652sp|Q8XEL8|MENG_SALTY S-adenosylmethionine:2-demethylmenaquinone methyltransferase
    • gi|16422656|gb|AAL22929.1| (AE008891) putative methyltransferase in menaquinone biosynthesis protein [Salmonella typhimurium LT2]
    • gi|16504650|emb|CAD09534.1| (AL627279) menaquinone biosynthesis protein [Salmonella enterica subsp. enterica serovar Typhi]
16. • gi|16120433|ref|NP_403746.1|_23:179 (NC_003143) possible transferase [Yersinia pestis]
    • gi|15978195|emb|CAC88948.1| (AJ414141) possible transferase [Yersinia pestis]
17. • gi|15805885|ref|NP_294583.1|_4:155 (NC_001263) S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Deinococcus radiodurans]
    • gi|17369587sp|Q9RW10|MENG_DEIRA Probable S-adenosylmethionine:2-demethylmenaquinone methyltransferase
    • gi|7473867|pir||A75466 2-demethylmenaquinone 2-C-methyltransferase (EC 2.1.1.-) DR0859 [similarity] - Deinococcus radiodurans (strain R1)
    • gi|6458578|gb|AAF10437.1|AE001940_1 (AE001940) S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Deinococcus radiodurans]
18. • gi|15237348|ref|NP_197149.1|_2:159 (NM_121650) S-adenosylmethionine:2-demethylmenaquinone methyltransferase-like protein [Arabidopsis thaliana]
    • gi|17368893sp|Q9FFE0|MEG2_ARATH Putative S-adenosylmethionine:2-demethylmenaquinone methyltransferase 2
    • gi|9759127|dbj|BAB09612.1| (AB005242) S-adenosylmethionine:2-demethylmenaquinone methyltransferase-like protein [Arabidopsis thaliana]
19. • gi|21537415|gb|AAM61756.1|_2:159 (AY085206) S-adenosylmethionine:2-demethylmenaquinone methyltransferase-like protein [Arabidopsis thaliana]
20. • gi|21232068|ref|NP_637985.1|_2:152 (NC_003902) s-adenosylmethionine:2-demethylmenaquinone methyltransferase [Xanthomonas campestris pv. campestris str. ATCC 33913]
    • gi|21113810|gb|AAM41909.1| (AE012375) s-adenosylmethionine:2-demethylmenaquinone methyltransferase [Xanthomonas campestris pv. campestris str. ATCC 33913]
21. • gi|21244872|ref|NP_644454.1|_18:173 (NC_003919) acyl transferase [Xanthomonas axonopodis pv. citri str. 306]
    • gi|21110581|gb|AAM38990.1| (AE012066) acyl transferase [Xanthomonas axonopodis pv. citri str. 306]
22. • gi|14861214|gb|AAK73570.1|AF305325_2_21:176 (AF305325) PmdF [Comamonas testosteroni]
23. • gi|15642363|ref|NP_231996.1|_6:153 (NC_002505) s-adenosylmethionine:2-demethylmenaquinone methyltransferase [Vibrio cholerae]
    • gi|17369117sp|Q9KPK1|MEG1_VIBCH S-adenosylmethionine:2-demethylmenaquinone methyltransferase 1
    • gi|11355822|pir||F82084 probable 2-demethylmenaquinone 2-C-methyltransferase (EC 2.1.1.-) VC2366 [similarity] - Vibrio cholerae (group O1 strain N16961)
    • gi|9656936|gb|AAF95509.1| (AE004307) s-adenosylmethionine:2-demethylmenaquinone methyltransferase [Vibrio cholerae]
24. • gi|13094205|dbj|BAB21456.3|_21:176 (AB050935) 4-Hydroxy-4-methyl-2-oxoglutarate aldolase [Pseudomonas straminea]
25. • gi|16120450|ref|NP_403763.1|_2:152 (NC_003143) S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Yersinia pestis]
    • gi|21362663sp|Q8ZJJ7|MENG_YERPE S-adenosylmethionine:2-demethylmenaquinone methyltransferase
    • gi|15978212|emb|CAC88968.1| (AJ414141) S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Yersinia pestis]
26. • gi|21243534|ref|NP_643116.1|_2:152 (NC_003919) S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Xanthomonas axonopodis pv. citri str. 306]
    • gi|21109099|gb|AAM37652.1| (AE011922) S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Xanthomonas axonopodis pv. citri str. 306]
27. • gi|15642667|ref|NP_232300.1|_2:152 (NC_002505) s-adenosylmethionine:2-demethylmenaquinone methyltransferase [Vibrio cholerae]
    • gi|17369115sp|Q9KNQ9|MEG2_VIBCH S-adenosylmethionine:2-demethylmenaquinone methyltransferase 2
    • gi|11354344|pir||B82049 2-demethylmenaquinone 2-C-methyltransferase (EC 2.1.1.-) VC2672 [similarity] - Vibrio cholerae (group O1 strain N16961)
    • gi|9657265|gb|AAF95813.1| (AE004332) s-adenosylmethionine:2-demethylmenaquinone methyltransferase [Vibrio cholerae]
28. • gi|21323691|dbj|BAB98318.1|_7:159 (AP005276) Demethylmenaquinone methyltransferase [Corynebacterium glutamicum ATCC 13032]
29. • gi|15241161|ref|NP_200437.1|_4:158 (NM_125009) S-adenosylmethionine:2-demethylmenaquinone methyltransferase-like [Arabidopsis thaliana]
    • gi|17368897sp|Q9FH13|MEG3_ARATH Putative S-adenosylmethionine:2-demethylmenaquinone methyltransferase 3
    • gi|9758753|dbj|BAB09117.1| (AB023029) S-adenosylmethionine:2-demethylmenaquinone methyltransferase-like [Arabidopsis thaliana]
30. • gi|16272452|ref|NP_438666.1|_1:152 (NC_000907) S-adenosylmethionine:2-demethylmenaquinone methyltransferase (menG) [Haemophilus influenzae Rd]
    • gi|1170921sp|P44738|MENG_HAEIN S-adenosylmethionine:2-demethylmenaquinone methyltransferase
    • gi|1074428|pir||G64153 2-demethylmenaquinone 2-C-methyltransferase (EC 2.1.1.-) HI0508 [similarity] - Haemophilus influenzae (strain Rd KW20)
    • gi|1573489|gb|AAC22166.1| (U32732) S-adenosylmethionine:2-demethylmenaquinone methyltransferase (menG) [Haemophilus influenzae Rd]
31. • gi|19552151|ref|NP_600153.1|_9:161 (NC_003450) COG0684:Demethylmenaquinone methyltransferase [Corynebacterium glutamicum]
32. • gi|15614501|ref|NP_242804.1|_12:166 (NC_002570) BH1938~unknown conserved protein in others [Bacillus halodurans]
    • gi|17369106sp|Q9KBI9|YJ38_BACHD Hypothetical protein BH1938
    • gi|10174556|dbj|BAB05657.1| (AP001513) BH1938~unknown conserved protein in others [Bacillus halodurans]
33. • gi|21227317|ref|NP_633239.1|_212:365 (NC_003901) hexulose-6-phosphate synthase [Methanosarcina mazei Goe1]
    • gi|20905670|gb|AAM30911.1| (AE013351) hexulose-6-phosphate synthase [Methanosarcina mazei Goe1]
34. • gi|15610989|ref|NP_218370.1|_3:157 (NC_000962) menG [Mycobacterium tuberculosis H37Rv]
    • gi|15843484|ref|NP_338521.1| (NC_002755) S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Mycobacterium tuberculosis CDC1551]
    • gi|17368389sp|P96224|MENG_MYCTU Probable S-adenosylmethionine:2-demethylmenaquinone methyltransferase
    • gi|7478935|pir||B70655 2-demethylmenaquinone 2-C-methyltransferase (EC 2.1.1.-) menG [similarity] - Mycobacterium tuberculosis (strain H37RV)
    • gi|1781103|emb|CAB06213.1| (Z83864) menG [Mycobacterium tuberculosis H37Rv]
    • gi|13883856|gb|AAK48335.1| (AE007188) S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Mycobacterium tuberculosis CDC1551]
35. • gi|16119556|ref|NP_396262.1|_20:176 (NC_003064) AGR_pAT_472p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17938913|ref|NP_535701.1| (NC_003306) demethylmenaquinone methyltransferase [Agrobacterium tumefaciens str. C58 (Dupont)] [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15162110|gb|AAK90703.1| (AE007901) AGR_pAT_472p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17743773|gb|AAL46017.1| (AE008954) demethylmenaquinone methyltransferase [Agrobacterium tumefaciens str. C58 (U. Washington)]
36. • gi|20093289|ref|NP_619364.1|_256:409 (NC_003552) hypothetical protein (multi-domain) [Methanosarcina acetivorans str. C2A] [Methanosarcina acetivorans C2A]
    • gi|19918645|gb|AAM07844.1| (AE011170) hypothetical protein (multi-domain) [Methanosarcina acetivorans str. C2A] [Methanosarcina acetivorans C2A]
37. • gi|15890696|ref|NP_356368.1|_21:177 (NC_003063) AGR_L_1159p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17937974|ref|NP_534763.1| (NC_003305) S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15158965|gb|AAK89153.1| (AE008256) AGR_L_1159p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17742746|gb|AAL45079.1| (AE009357) S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Agrobacterium tumefaciens str. C58 (U. Washington)]
38. • gi|21224278|ref|NP_630057.1|_26:181 (NC_003888) transferase [Streptomyces coelicolor A3(2)]
    • gi|7481819|pir||T35705 transferase - Streptomyces coelicolor
    • gi|2808768|emb|CAA16197.1| (AL021411) transferase [Streptomyces coelicolor A3(2)]
39. • gi|15826911|ref|NP_301174.1|_3:157 (NC_002677) putative S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Mycobacterium leprae]
    • gi|17368730sp|Q9CDD2|MENG_MYCLE Probable S-adenosylmethionine:2-demethylmenaquinone methyltransferase
    • gi|13092458|emb|CAC29574.1| (AL583917) putative S-adenosylmethionine:2-demethylmenaquinone methyltransferase [Mycobacterium leprae]
40. • gi|2497266sp|Q48806|DLPA_LEGPN_397:561 DLPA PROTEIN
    • gi|2120838|pir||S61390 dlpA protein - Legionella pneumophila
    • gi|563806|gb|AAA79904.1| (U07940) DlpA [Legionella pneumophila]
41. • gi|17549165|ref|NP_522505.1|_24:179 (NC_003296) PROBABLE TRANSFERASE PROTEIN [Ralstonia solanacearum]
    • gi|17431416|emb|CAD18095.1| (AL646081) PROBABLE TRANSFERASE PROTEIN [Ralstonia solanacearum]
42. • gi|11498467|ref|NP_069695.1|_232:386 (NC_000917) D-arabino 3-hexulose 6-phosphate formaldehyde lyase (hps-1) [Archaeoglobus fulgidus]
    • gi|7429976|pir||E69357 D-arabino 3-hexulose 6-phosphate formaldehyde lyase (hps-1) homolog - Archaeoglobus fulgidus
    • gi|2649745|gb|AAB90381.1| (AE001045) D-arabino 3-hexulose 6-phosphate formaldehyde lyase (hps-1) [Archaeoglobus fulgidus]
43. • gi|1196735|gb|AAA88423.1|_19:175 (M18279) unknown protein [Pseudomonas sp.]
44. • gi|20094885|ref|NP_614732.1|_5:153 (NC_003551) Demethylmenaquinone methyltransferase [Methanopyrus kandleri AV19]
    • gi|19888118|gb|AAM02662.1| (AE010437) Demethylmenaquinone methyltransferase [Methanopyrus kandleri AV19]
45. • gi|15678908|ref|NP_276025.1|_24:180 (NC_000916) conserved protein [Methanothermobacter thermautotrophicus] [Methanothermobacter thermautotrophicus str. Delta H]
    • gi|7450631|pir||F69218 conserved hypothetical protein MTH888 - Methanobacterium thermoautotrophicum (strain Delta H)
    • gi|2621982|gb|AAB85386.1| (AE000864) conserved protein [Methanothermobacter thermautotrophicus str. Delta H]
46. • gi|15890996|ref|NP_356668.1|_7:180 (NC_003063) AGR_L_1765p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17937670|ref|NP_534459.1| (NC_003305) conserved hypothetical protein [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15159319|gb|AAK89453.1| (AE008287) AGR_L_1765p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17742412|gb|AAL44775.1| (AE009327) conserved hypothetical protein [Agrobacterium tumefaciens str. C58 (U. Washington)]
47. • gi|15668825|ref|NP_247628.1|_15:169 (NC_000909) S-adenosylmethionine:2-demethylmenaquinone methyltransferase (menG) [Methanococcus jannaschii] [Methanocaldococcus jannaschii]
    • gi|2496093sp|Q58060|Y644_METJA Hypothetical protein MJ0644
    • gi|2128023|pir||D64380 conserved hypothetical protein MJ0644 - Methanococcus jannaschii
    • gi|1591356|gb|AAB98638.1| (U67512) S-adenosylmethionine:2-demethylmenaquinone methyltransferase (menG) [Methanococcus jannaschii] [Methanocaldococcus jannaschii]
48. • gi|10956954|ref|NP_049174.1|_8:169 (NC_002033) unknown [Novosphingobium aromaticivorans]
    • gi|11280279|pir||T31246 hypothetical protein 933 - Sphingomonas aromaticivoransm plasmid pNL1
    • gi|3378387|gb|AAD03970.1| (AF079317) unknown [Novosphingobium aromaticivorans]
49. • gi|10956955|ref|NP_049175.1|_16:180 (NC_002033) unknown [Novosphingobium aromaticivorans]
    • gi|11280280|pir||T31247 hypothetical protein 938 - Sphingomonas aromaticivorans plasmid pNL1
    • gi|3378388|gb|AAD03971.1| (AF079317) unknown [Novosphingobium aromaticivorans]
50. • gi|13472133|ref|NP_103700.1|_16:190 (NC_002678) hypothetical protein [Mesorhizobium loti]
    • gi|14022878|dbj|BAB49486.1| (AP002999) hypothetical protein [Mesorhizobium loti]
51. • gi|21225443|ref|NP_631222.1|_43:216 (NC_003888) putative transferase [Streptomyces coelicolor A3(2)]
    • gi|9716983|emb|CAC01652.1| (AL391072) putative transferase [Streptomyces coelicolor A3(2)]
52. • gi|16263862|ref|NP_436654.1|_13:185 (NC_003078) HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
    • gi|15139986|emb|CAC48514.1| (AL603642) HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
53. • gi|17549454|ref|NP_522794.1|_11:172 (NC_003296) PUTATIVE TRANSFERASE PROTEIN [Ralstonia solanacearum]
    • gi|17431707|emb|CAD18384.1| (AL646083) PUTATIVE TRANSFERASE PROTEIN [Ralstonia solanacearum]
54. • gi|6320847|ref|NP_010926.1|_5:183 (NC_001137) Hypothetical ORF; Yer010cp [Saccharomyces cerevisiae]
    • gi|731439sp|P40011|YEK0_YEAST HYPOTHETICAL 25.6 KD PROTEIN IN NTF2-SRP1 INTERGENIC REGION
    • gi|1077632|pir||S50468 hypothetical protein YER010c - yeast (Saccharomyces cerevisiae)
    • gi|603602|gb|AAB64543.1| (U18778) Yer010cp [Saccharomyces cerevisiae]
55. • gi|21401242|ref|NP_657227.1|_2:93 (NC_003995) hypothetical protein predicted by GeneMark [Bacillus anthracis A2012] [Bacillus anthracis str. A2012]

              10             20             30         40             5
              |              |              |          |              
   1 MAISFRPTADLVDDIGP.....DVRSCDLQ.FRQ..F..G.GRSQFAGPISTVRCF.....QDNA
   2 -------TPDLCDAYPE.....LVQVVEPM.FSN..F..G.GRDSFGGEIVTIKCF.....EDNS
   3 -GLAQAGVATVHEAMG-.....RSGLLHHR.LRP..I..Y.AGCRIAGTAVTVSVPp....GDNW
   4 -------TPDLCDAYPE.....LVQVVEPM.FSN..F..G.GRDSFGGEIVTIKCF.....EDNS
   5 -GLAKCGVATVHEAQG-.....RTGLLAPT.MRP..I..Y.TGARIAGSAVTISAPp....GDNW
   6 -GLAACGVATVHEAQG-.....RTGLLASY.MRP..I..Y.RGARVAGSALTISAPp....GDNW
   7 --LQRFGTATIHEAQG-.....QRGAIDPR.IAA..L..D.PARRLVGRALTVDMRp....SDNL
   8 ----KYDTSELCDIYQE.....DVNVVEPL.FSN..F..G.GRASFGGQIITVKCF.....EDNG
   9 -ALAECGVATVHEAMG-.....RTGLMQSY.MRP..V..W.RGARVAGTAVTVSIPp....ADNW
  10 KRLSQFGVATIHEAMG-.....RVGLLRPY.IRP..A..Y.TGAKLCGPAVTVLLQp....GDNW
  11 ---AFVTTAEVCDANQEmirsgQLRALQPV.FQI..Y..G.RRQIFSGPVVTVKVF.....EDNG
  12 ---MMIPVTDLCDAHEDqlasgAVRVLAPV.FRS..F..G.ARAAFAGPAATLKVF.....EDNG
  13 -----LATAEVCDANADlimngELRALQPI.FQI..Y..G.RRQVFAGPIVTLKVY.....EDNV
  14 ----YIDTSELCDIYLD.....QVDVVEPI.FSS..F..G.GVNRFYGKVTTVKCF.....ENNG
  15 ----KYDTSELCDIYQE.....DVNVVEPL.FSN..F..G.GRSSFGGQIITVKCF.....EDNG
  16 QRFAEYGVATVHEAQL-.....RQGLLDER.IKP..I..Q.QGRCIAGNAVTVLVTp....GDNW
  17 ----FIPTTDLSDAQP-.....QAQVAAPV.LRD..F..G.GRTRFQGAAVTLRIS.....ENNP
  18 ---AFVTTAEVCDANQElirsgQLRALQPI.FQI..Y..G.RRQIFSGPVVTVKVF.....EDNG
  19 ---AFVTTAEVCDANQElirsgQLRALQPI.FQI..Y..G.RRQIFSGPVVTVKVF.....EDNG
  20 ----TWTTPDLCDRFP-.....EVAVAEPL.FRH..F..G.GRTTFSGPIATVRCV.....EDNS
  21 -GLAQAGVATVHEAQA-.....RSGLLHHR.LRP..I..Y.TGCRIAGTAVTVSIPp....GDNW
  22 -GLAALGSATVHEAMG-.....RVGLLKPY.MRP..I..Y.AGKQVSGTAVTVLLQp....GDNW
  23 -------TPDLCDKYES.....QVTLLNLP.LQN..F..G.QRSAFWGEIVTVRCY.....HDNS
  24 -GLAALGSATVHEAMG-.....RVGLLKPY.MRP..I..Y.AGKQVSGTAVTVLLQp....GDNW
  25 ----KYDTSDLCDIYHE.....EVNVVEPL.FSN..F..G.GRTSFGGKITTVKCF.....EDNG
  26 ----TWTTPDLCDRYP-.....DAMIAEPL.FRH..F..G.GRTAFAGPLATVRCF.....EDNS
  27 ----EYNTSALCDIYLD.....QVDVVEPM.FSN..F..G.GCASFAGQITTIKCY.....EDNG
  28 ---EFIATADLVDIIGD.....NAQSCDTQ.FQN..L..G.GATEFHGIITTVKCF.....QDNA
  29 -----FATAEACDSNAElisngDLRALHPI.FKI..Y..G.QRRCFSGPIVTLKVF.....EDNV
  30 ---MFIDTSELCDLYAE.....QVDVVEPI.FSS..F..G.GVSNFYGKVTTVKCF.....ESNG
  31 ---EFIATADLVDIIGD.....NAQSCDTQ.FQN..L..G.GATEFHGIITTVKCF.....QDNA
  32 --FRTIPTTCISDALD-.....GLTNLTST.IKP..L..N.ENDQVVGPARTVQVAs....GDNL
  33 EIFKEVSTSNISDAMH-.....RKGAMKGI.HPL..V..-.-RGKMVGPAVTVQCFp....GDWA
  34 --ISFRPTADLVDDIGP.....DVRSCDLQ.FRQ..F..G.GRSQFAGPISTVRCF.....QDNA
  35 DKFRELPVANISDSMH-.....RMYAGGAE.LRP..M..H.RDGKLVGRALTVKAPp....GDNL
  36 EIFKEVSTSNISDAMH-.....RKGAMKGI.HPL..V..-.-RGKMVGTAVTVQCFa....GDWA
  37 EALAKFSPATIHEAQG-.....RRGALSSR.LKP..V..D.YRMKLCGPAFTVRCAp....RDNI
  38 -RLGEVPAAHVGDALE-.....RMTVMDGG.IRL..L..T.ERAALLGNALTVDVRs....GDNL
  39 --VSFRPTADLVDSIGV.....DVRSCDLQ.FRQ..F..G.GCSEFAGPISTVRCF.....QDNA
  40 QQLINCNSAEISDALDA.....CGIEGGLLsIKP..L..S.QGMKIIGPAYTIQYLpr6kgTAFH
  41 --LQALPVAAISDNMHR.....NMGTGSLQ.PFH..K..P.VANTMAGTAVTARSRg....GDNL
  42 ELLMRVSTPNVSDAMH-.....RAKAMDGV.YPL..V..-.RGKKIVGKAVTVSTMd....GDWA
  43 EKLQKVETATIGHSQH-.....-WGFMDRR.IQP..L..L.RGKRIAAAAVTLAIPg....QDST
  44 ------PSPVLSDALGK.....RY--VLRG.IRH..I..V.GPVPICGRAVTVLVEg....TDWG
  45 -LLSGISAPQISDALKS.....VTGEVGVI.PSI..K..PvNNLRVCGRVVTVRTSq....HDWG
  46 EKLLTISVATLATALYKrgl..RNQVIQGV.RPL..G..Y.KGKNMVGPAFTLRYMp13frNPAH
  47 -ILKNFSVPNLCDAGA-.....--KPLNGI.KPI..L..E.NQKLVFGEAITVKISy....NDWG
  48 ERLNTVGVTALSDALDR.....LEIAGQLIgLAP..V..A.RGMKFSGRAFTIRMLpvg..LTGG
  49 -RLGSFDTCTISDALDTlg...LTGAVIGL.APL..T..I.PGRRIAGEAVTVKLGpp6glPKRH
  50 EGLREIGAATVAGTLGH.....MGFRNPHM.VGP..VaqN.HGKSIVGPALTLQFLp14adPETQ
  51 --LNRVSSATACAKLHE.....LGIRRSYL.SGPtaL..D.LGNKVTGPARTLQFMp15yvERST
  52 -KFEGVSCATLCTALFKrgl..RNQFIQDV.RPV..A..P.KAKNMVGQAFTLRYIp13fqNPEH
  53 -LFRGLDTPAVSDALDKlg...LPGQCLGI.MPL..D..H.YATPIVGPAFTVRYVsas..TPPG
  54 QKLQRFSTCDISDGLLNvy6ptGGYFPNLT.AIS..P..P.QNSSIVGTAYTVLFApi...DDPR
  55 -----WKTTDLCDEFEN.....ELQICRQP.FRS..F..G.KKEQFHGKIATVKVK.....DDNV


      0        60         70             80        90       100       1
     |         |          |              |         |         |        
   1 LLKSVLSQPSAGGVLV.IDGAGSLH.....TALVGDVIAELARSTGWTGLIVHGAVRDAAALRGI
   2 LVKEQVDKDGKGKVLV.VDGGGSLR.....RALLGDMLAEKAAKNGWEGIVVYGCIRDVDVIAQT
   3 MMHVAIEQLRDGDLLV.VAPTSECC.....DGYFGDLLATSAQARGCRGLIIDAGVRDVRDLTAM
   4 LVKEQADQPGAGKVLV.VDGGGSLR.....RALLGDMIAEKAAKNGWEGLVIYGCVRDVDVLAQT
   5 MVHVAIEQLKEGDVLL.LAPTSPCT.....DGYFGDLLATSAQARGCRGLIIDAGVRDVRDLKQM
   6 MVHVAIEQLKAGDILL.LAPTSPCE.....DGYFGDLLATSAQARGCRGLVIDAGVRDVRDLTEM
   7 MIHYALTKARPGDVLV.VDAKGFVD.....AGPWGDILTLAAQEIGMAGLVIDGAVRDADSIIEM
   8 LLYDLLEQNGRGRVLV.VDGGGSVR.....RALVDAELARLAVQNEWEGLVIYGAVRQVDDLEEL
   9 MIHVAVEQCREGDILV.VAPTSPCD.....AGYFGELLATSLMVRGVRGLIIEAGVRDVSELEEI
  10 MFHVAAEQVQEGDVIV.AGCTTESE.....DGFFGELLATSLTARGCKGLVIDGGVRDVADLEKM
  11 LIRHFLEEKGNGRVLV.VDGGGSLR.....CAILGGNPVVQAQNNGWAGIIVNGCIRDVDEINGC
  12 LVRAMLEQPGEGRVLV.VDGGGSLR.....CALVGGNLAKLAEDNGWEGVLVNGCVRDTRELAAC
  13 LIREFLEEKGHGRVLV.VDGGGSLR.....CAILGGNPVQQAQNNGWAGIVVNGCIRDVDEINGC
  14 LITDILEENGEGRVLL.IDGGGAVR.....RALVDAELAQLAVDNGWEGIIVYGAVRQIQQLEEM
  15 LLYDLLEQNGRGRVLL.VDGGGSVR.....RALVDAELARLATQNEWEGLVIYGAVRQVDDLEEL
  16 MFHVAVEQCQPGDVLL.VAPTSECH.....DGFFGDLLATSLLARGVVALVGDIGIRDSQTLREM
  17 LVRQTLQTPGAGRVLV.VDGGGSLN.....CALLGGNLGVFGVENGWEGVIIHGCVRDTAELREL
  18 LIRQFIEEKGNGRVLV.VDGGGSQR.....CAILGGNPVVQAQNNGWAGIVVNGCIRDVDEINGC
  19 LIRQFIEEKGNGRVLV.VDGGGSQR.....CAILGGNPVVQAQNNGWAGIVVNGCIRDVDEINGC
  20 RIRELASTPGDGRVLV.VDGQGSLR.....QALFGDQIGAQAVANGWAGVLIHGCVRDVEILAGL
  21 MMHVAIEQLHAGDVLV.VAPTSDCC.....DGYFGDLLATSAQARGCRGLIIDAGVRDVRDLTAM
  22 MMHVAAEQIQPGDIVV.AAVTAECS.....DGYFGDLLATSFQARGARALIIDAGVRDVKTLQEM
  23 KVRDVLSQNGKGKVLV.VDGHGSCH.....KALMGDQLAILAIKNDWEGVIIYGAVRDVVAMSEM
  24 MMHVAAEQIQPGDIVV.AAVTAECT.....DGYFGDLLATSFQARGARALIIDAGVRDVKTLQEM
  25 LLFDLLEENGLGRVLV.VDGGGSVR.....RALINAELAELALKNEWEGIVVYGAVRQVDDLAEL
  26 RVRELAATPGDGRVLV.VDGQGSLK.....HALLGDQIAANAVANGWAGVLIHGCVRDVEILATL
  27 LIRETLEQDGLGRILL.IDGGGSLR.....RALIDAELAALAEENEWEGIVVYGSVREVDELEEM
  28 LLKSILSEDNPGGVLV.IDGDASVH.....TALVGDIIAGLGKDHGWSGVIVNGAIRDSAVIGTM
  29 LVRNQLETKGEGGVLV.IDGGGSMR.....CALVGGNLGQLAQNNGWSGIVVNGCVRDVDEINDC
  30 LIAEVLEENGEGRVLV.IDGGGAVR.....RGLIDAELAQLAVDNGWEGIIVYGAVRQIQQLENL
  31 LLKSILSEDNPGGVLV.IDGDASVH.....TALVGDIIAGLGKDHGWSGVIVNGAIRDSAVIGTM
  32 AVLKAMYEASPGDVIV.IDAKGDCT.....RAIAGDFVLGMAKTLGIAGFVVDGAIRDIRASKAL
  33 KTVEAIDLAKPGDVIV.IYNESK-D.....IACWGGLATLSSLNKGIAGVVIEGAVRDIDEVENL
  34 LLKSVLSQPSAGGVLV.IDGAGSLH.....TALVGDVIAELARSTGWTGLIVHGAVRDAAALRGI
  35 MLHKAMDMAVDGDVIV.MDAAGDVT.....HALMGEMMLDYAHRRGVVGFVLNGAIRDADAFLEM
  36 KTVEAIDIAKEGDVIV.IYNESK-D.....IACWGGLATLSSLNKGIAGVVIEGAVRDIDEVETL
  37 MLQLAINYAKPGDIIV.VSAGEYEE.....AGSFGDVLANACLAKGIGGLVTDTGVRDTLQLRDL
  38 AVHRALDEARPGDVLV.VNGHGDTT.....RALVGDLIGEIMVNTGVTGAVVDGAVRDVRALSEM
  39 LLKSVLSQTSAGGVLV.VDGAGSLH.....TALVGDVIAELAHSNGWAGLIVNGAVRDAAALRGI
  40 NAANYIDKVPKHSVIV.IDNNGQID.....CTVWGDLLTHTALRNNIMGTVVHGAVRDVESIRST
  41 TYLRALEFCRPGDVLV.IDAGGDLQ.....NAVVGGILTYYAARIGVVGVVIDGAVRDVAELRER
  42 KPVEAINVAGEGDVLV.IKVSGD-T.....AAVWGELATRSCINRKIAGVIIDGAVRDVDDIREL
  43 LLHHTLGLLRPGDILV.VDRLGDDK.....HACWGGGVTVAAKAAGAVGGIVDGPCTDLTEIEDS
  44 TVVEAIDEAEEGDVLV.IQARDR-A.....RAYWGGLSSLSAKRKGLAGTVVDGLVRDVDDVREI
  45 TSVMAIDAAAPGEIIF.IGADGD-E.....RAVWGELTSKTAMKRGIAGVVIYGSCRDIDALLEL
  46 PQRVAIETCPPGHVLV.MDSRKDPS.....AASAGDILVTRLMVRGGAGIVSDGGFRDAATIAEL
  47 TLIKTISFAKNKFIVAeVVGEGKYE.....TAVWGGLASLNAKIKGVRGVVIDGCVRDVEDIKAL
  48 SVGDYIDEVPPGAVVA.IDNGGILN.....QTVWGDILTYVAHTKGIAATVIDGACRDSDRCVAL
  49 LCAAAVMSARNGEVIV.IEHRGRAD.....VSGWGGLLSRGAIKYGLAGVIIDGACRDVDESREL
  50 LHRHVLYHAQEGDVVV.VDARGDMS.....SGVFGDMMSTYFKGRGGAGIVIDGCMRDRPNVEKL
  51 ALWAVLEEVQPGDVLV.VQAYGSAF.....TGCLGDMLVRYFKRKGGAGIVVDGRIRDAPRVREL
  52 PQRAAVEKCPPGFVMV.MDSRKDPR.....AASAGSILVSRLMVRGVAGVVTDGGFRDSPEIGEL
  53 TVGDFIDDVADGDVVV.IDNGGRTD.....CTVWGDIMTQYAGQRRIAGTVIDGVCRDVSRALGD
  54 PAVNYIDSVPPNSILV.LALEPHLQs10itQAMYGGLMSTRAQYLKSNGTVVFGRIRDVDEHRTL
  55 LVKEGLQTLPXXTVLV.VDGGASTN.....CALLGDNLAAIAEERKLAGIIVNG-----------


      10           120          130          140       150       
      |             |            |            |         |       
   1 DIGIK.ALGT...NPRKSTKT.GAGE..RDVEITLGG...VTFVPGDIAYSDDDGIIVV
   2 DLGVQ.ALAS...HPLKTDKR.GIGD..LNVAVTFGG...VTFRPGEFVYADNNGIIV-
   3 GFPVW.SRAI...CAQGTIKE.TLGA..VNVPLVCAG...QLIQPGDVVVADDDGVCVV
   4 DLGVQ.ALAP...HPMKTDKR.GIGD..LNVVVTFAS...VTFRPGEYVYADNNGVIV-
   5 NFPVW.SKAI...HAQGTIKA.TLGS..VNIPVVCAN...ALVNPGDVVIADDDGVCVV
   6 NFPVW.SKAI...YAQGTVKN.TLGS..VNVPVVCAN...ALVNPGDVIVADDDGVCVV
   7 GFPVF.CRGL...CIKGTNKH.QPGR..VNVPVVIGG...VPIQPGDVMVGDRDGLVVV
   8 DIGIQ.AMAA...IPVGAAGE.GIGE..SDVRVNFGG...VTFFSGDHLYADNTGII--
   9 GFPVW.SRFV...SAQGTVKA.TLGS..VNVPIVCAG...ATVAPGDVVIADDDGVMVV
  10 DFPVF.SRAV...NAKGTVKA.TLGS..VNIPVVVAN...AVVNPGDVVVADVDGVVVV
  11 DIGVR.ALAS...HPIKASKK.GLGE..QRVSLNIAG...TRICDGEWLYADTDGILV-
  12 NVGVH.ALAA...HPRKSFKK.NQGE..RDIGVQMPG...AYIHPGEWIYGDEDGVLV-
  13 DIGVR.ALNS...HPMKANKK.GIGE..KHVPVTIAG...TRICDGEWLYADTDGIL--
  14 DIGIH.ALAP...IPVGADKQ.NIGE..IDVPVNFGG...VTFFPEDYVYADLTGII--
  15 DIGIQ.AIAA...IPVGAAGE.GIGE..SDVRVNFGG...VTFFSGDHLYADNTGII--
  16 NFPVW.SRAV...WAQGTVKA.SLGS..VNVPVICAG...QLVNPGDIVVADDDGVVIV
  17 DLGIR.ALAA...HPRRSGKL.EEGE..RDVPVTFAG...VTIRPGDHVVADEDGWLVL
  18 DIGVR.ALAS...HPIKASKK.GLGE..QRVPVNIAG...TRICDGEWLYADTDGILV-
  19 DIGVR.ALAS...HPIKARKK.GLGE..QRVPVNIAG...TRICDGEWLYADTDGILV-
  20 PLGVL.ALAA...CPRRTERR.DLGD..VDVPVNFAG...VAFVPGHWLYADANGVVV-
  21 QFPAW.SRAI...CAQGTIKE.TLGS..VNVPLVCAG...QLIQPGDVVVADDDGVCVV
  22 DFPVW.SKAI...SSKGTIKA.TLGS..VNIPIVCAG...MLVTPGDVIVADDDGVVCV
  23 DLGIK.ALGT...SPFKTEKR.GAGQ..VNVTLTMQN...QIVEPGDYLYADWNGIL--
  24 DFPVW.SKAI...SSKGTIKA.TLGS..VNIPIVCAG...MLVTPGDVIVADDDGVVCV
  25 DIGIQ.AMAA...IPVGAADE.GVGE..SDIRVNFGG...VTFFSGDHLYADNTGII--
  26 PLGVL.ALAA...CPRRTERR.DLGD..VDVPVNFAG...VPFVPGHWLYADANGVLV-
  27 SIGIQ.AIAS...IPVGATSQ.GIGE..VDIPVNFGG...VTFLPEDYLYADNTGII--
  28 TFGCK.ALGT...NPRKSTKT.GSGE..RDVVVSIGG...IDFIPGHYVYADSDGIIV-
  29 DVGVR.ALGS...NPLKSTKK.GHGE..KNVPVHIGG...TLIRDGEWLYADSDGIL--
  30 DIGIH.ALAP...IPVSADES.SAGE..SDIPVNFGG...VTFFPEDYIYADLTGII--
  31 TFGCK.ALGT...NPRKSTKT.GSGE..RDVVVSIGG...IDFIPGHYVYADSDGIIV-
  32 NFPIF.CRGT...TIAASKKT.GIGN..INVPISCGG...VPIRPGDLIVGDADGVTVI
  33 GLPIY.TSNT...VPNAGDPK.GFGE..INAEITCGS...QAVKPGDYIIGDESGVVVV
  34 DIGIK.ALGT...NPRKSTKT.GAGE..RDVEITLGG...VTFVPGDIAYSDDDGIIVV
  35 NIPAF.AVGV...THRGPYKN.GPGE..INTPIAIGG...MVITPGDLIVGDADGVVVV
  36 GLPIY.TSNT...VPNAGDPK.GFGE..INAEITCGS...QAVKAGDYIIGDESGVVVV
  37 GFPVF.SLSV...CIKGTVKE.TIAA..VNDSIIVGG...ETINPGDIVVGDADGLVVV
  38 GLTVY.ARAI...TPAGPFKD.GPGA..VGRPVAVGG...MVVEAGDVLVGDADGVVVV
  39 DIGIK.ALGT...NPRKSTKI.GTGE..RHVEVNLGG...VTFVPGEVVYSDDDGIVVV
  40 NYPVF.CTGI...YMCSGKNR.VYKAn.EQCPLSING...VTINPGDIIFADDNGVLVI
  41 EFPVY.ARGV...THRGPYKD.GPGE..INVPVSVGG...MIVHPGDVVVGDQDGLLAI
  42 GFPLF.ARKE...VPNAGEPK.GFGE..INVKVICGG...VEVNPGDWIIADDNGVMVI
  43 DFPMW.CRGM...SPITTRLY.NLGGt.LNLPISCGN...VPVKAGDVILADESGVLVL
  44 GYTVF.ARGV...TPRAGTHR.RSGK..INVDLYVSG...VLVRPGDIIVGDESGVVVV
  45 DFPVF.SRDY...VPCAGEPR.AEGQ..LNVDLECDG...VMVKKGDLLLGDESGVVVV
  46 DIPAYhTRPS...SPTNLTKH.EAIE..INGPIGCGD...APVFPGDIIVGDADCVIVI
  47 KFPVF.AKNF...CPNAGKPL.NLGE..INVAVNCCG...VIVEPGDIIVGDCNGVVVI
  48 NYPVF.SRCV...TMRTAKDRaTAVA..NNDPIQLAG...VRVEPGDWLVGDSDGVVAI
  49 GLPIF.GRNA...VPVTARGR.IAEHa.WDCPVTIGT...VVVKPGDWVVADGSGVVFV
  50 DLPLW.LRGW...TPNYHVQT.SIYPnaVNVPIACGG...VTVIPGDIIVADDDGVVVV
  51 GVPIW.CTGT...TPHYASQS.ELFPwaYDVPVAAGG...VLTLPGDLVVADDDGAVVV
  52 DIPAYhSRPS...APTNLTLH.QALD..INVPIGCGD...VAVWPGDVVVGDREGVVVV
  53 GYPLF.TRGR...FMRTGKDR.VQVEa.VNGTVSIGA...ARVVARDIVIADANGVVVV
  54 NHPVF.AYGVgscAPKAVVKA.VGTN..VQLKILTSDgvtQTICPGDYIAGDNNGIV--
  55 -----.----...--------.----..---------...-------------------