a2m2html output for file tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0154 Pantothenate synthetase, Mycobacterium tuberculosis
- gi|15643835|ref|NP_228883.1|_1:278 (NC_000853) pantoate--beta-alanine ligase [Thermotoga maritima]
- gi|8134623|sp|Q9X0G6|PANC_THEMA Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|7449525|pir||E72296 pantoate--beta-alanine ligase - Thermotoga maritima (strain MSB8)
- gi|4981622|gb|AAD36154.1|AE001768_3 (AE001768) pantoate--beta-alanine ligase [Thermotoga maritima]
- gi|8134620|sp|O86953|PANC_THENE_1:278 Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|3282095|emb|CAA07518.1| (AJ007446) hypothetical protein [Thermotoga neapolitana]
- gi|15610738|ref|NP_218119.1|_2:308 (NC_000962) panC [Mycobacterium tuberculosis H37Rv]
- gi|15843214|ref|NP_338251.1| (NC_002755) pantoate--beta-alanine ligase [Mycobacterium tuberculosis CDC1551]
- gi|2498744|sp|O06280|PANC_MYCTU Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|7449523|pir||C70955 probable panC protein - Mycobacterium tuberculosis (strain H37RV)
- gi|2113974|emb|CAB08942.1| (Z95557) panC [Mycobacterium tuberculosis H37Rv]
- gi|13883568|gb|AAK48065.1| (AE007170) pantoate--beta-alanine ligase [Mycobacterium tuberculosis CDC1551]
- gi|15607078|ref|NP_214460.1|_3:278 (NC_000918) pantothenate synthetase [Aquifex aeolicus]
- gi|8134617|sp|O67891|PANC_AQUAE Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|7449522|pir||G70482 pantothenate synthetase - Aquifex aeolicus
- gi|2984326|gb|AAC07847.1| (AE000774) pantothenate synthetase [Aquifex aeolicus]
- gi|12620802|gb|AAG61078.1|AF322013_197_1:279 (AF322013) ID912 [Bradyrhizobium japonicum]
- gi|15799817|ref|NP_285829.1|_1:280 (NC_002655) pantothenate synthetase [Escherichia coli O157:H7 EDL933]
- gi|15829391|ref|NP_308164.1| (NC_002695) pantothenate synthetase [Escherichia coli O157:H7]
- gi|12512848|gb|AAG54437.1|AE005189_10 (AE005189) pantothenate synthetase [Escherichia coli O157:H7 EDL933]
- gi|13359593|dbj|BAB33560.1| (AP002550) pantothenate synthetase [Escherichia coli O157:H7]
- gi|16128126|ref|NP_414675.1|_1:280 (NC_000913) pantothenate synthetase [Escherichia coli K12]
- gi|400728|sp|P31663|PANC_ECOLI Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|7449518|pir||E64736 pantoate--beta-alanine ligase (EC 6.3.2.1) - Escherichia coli
- gi|14488684|pdb|1IHO|A Chain A, Crystal Apo-Structure Of Pantothenate Synthetase From E. Coli
- gi|14488685|pdb|1IHO|B Chain B, Crystal Apo-Structure Of Pantothenate Synthetase From E. Coli
- gi|304928|gb|AAA24272.1| (L17086) pantothenate synthetase [Escherichia coli]
- gi|1786325|gb|AAC73244.1| (AE000122) pantothenate synthetase [Escherichia coli K12]
- gi|15640612|ref|NP_230241.1|_1:284 (NC_002505) pantoate--beta-alanine ligase [Vibrio cholerae]
- gi|13431777|sp|Q9KUD1|PANC_VIBCH Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|11279931|pir||H82303 pantoate--beta-alanine ligase VC0591 [imported] - Vibrio cholerae (group O1 strain N16961)
- gi|9655022|gb|AAF93758.1| (AE004144) pantoate--beta-alanine ligase [Vibrio cholerae]
- gi|15965915|ref|NP_386268.1|_1:280 (NC_003047) PROBABLE PANTOATE--BETA-ALANINE LIGASE PROTEIN [Sinorhizobium meliloti]
- gi|15075184|emb|CAC46741.1| (AL591789) PROBABLE PANTOATE--BETA-ALANINE LIGASE PROTEIN [Sinorhizobium meliloti]
- gi|17987876|ref|NP_540510.1|_1:281 (NC_003317) PANTOATE-BETA-ALANINE LIGASE [Brucella melitensis]
- gi|17983609|gb|AAL52774.1| (AE009595) PANTOATE-BETA-ALANINE LIGASE [Brucella melitensis]
- gi|15891455|ref|NP_357127.1|_47:336 (NC_003063) AGR_L_2698p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
- gi|15159863|gb|AAK89912.1| (AE008334) AGR_L_2698p [Agrobacterium tumefaciens str. C58 (Cereon)]
- gi|16123551|ref|NP_406864.1|_1:280 (NC_003143) pantoate--beta-alanine ligase [Yersinia pestis]
- gi|15981329|emb|CAC92632.1| (AJ414157) pantoate--beta-alanine ligase [Yersinia pestis]
- gi|15827027|ref|NP_301290.1|_5:302 (NC_002677) putative pantoate-[beta]-alanine ligase [Mycobacterium leprae]
- gi|13432221|sp|O69524|PANC_MYCLE Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|13092574|emb|CAC29738.1| (AL583917) putative pantoate-[beta]-alanine ligase [Mycobacterium leprae]
- gi|17937190|ref|NP_533979.1|_1:283 (NC_003305) pantoate--beta-alanine ligase [Agrobacterium tumefaciens str. C58 (U. Washington)]
- gi|17741883|gb|AAL44295.1| (AE009278) pantoate--beta-alanine ligase [Agrobacterium tumefaciens str. C58 (U. Washington)]
- gi|16079299|ref|NP_390123.1|_1:281 (NC_000964) pantothenate synthetase [Bacillus subtilis]
- gi|1709569|sp|P52998|PANC_BACSU Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|7449521|pir||H69671 pantothenate synthetase panC - Bacillus subtilis
- gi|1146241|gb|AAB38449.1| (L47709) pantothenate synthetase [Bacillus subtilis]
- gi|2634660|emb|CAB14158.1| (Z99115) pantothenate synthetase [Bacillus subtilis]
- gi|21284246|ref|NP_647334.1|_3:280 (NC_003923) pantoate beta-alanine ligase [Staphylococcus aureus subsp. aureus MW2]
- gi|21205689|dbj|BAB96382.1| (AP004830) pantoate beta-alanine ligase [Staphylococcus aureus subsp. aureus MW2]
- gi|19113733|ref|NP_592821.1|_1:278 (NC_003424) putative pantoate--beta-alanine ligase [Schizosaccharomyces pombe]
- gi|1172007|sp|Q09673|PANC_SCHPO Putative pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|1076893|pir||S55486 probable pantoate--beta-alanine ligase (EC 6.3.2.1) - fission yeast (Schizosaccharomyces pombe)
- gi|854607|emb|CAA89958.1| (Z49811) putative pantoate--beta-alanine ligase [Schizosaccharomyces pombe]
- gi|15925588|ref|NP_373122.1|_3:280 (NC_002758) pantoate beta-alanine ligase [Staphylococcus aureus subsp. aureus Mu50]
- gi|15928184|ref|NP_375717.1| (NC_002745) pantoate beta-alanine ligase [Staphylococcus aureus subsp. aureus N315]
- gi|13702555|dbj|BAB43696.1| (AP003137) pantoate beta-alanine ligase [Staphylococcus aureus subsp. aureus N315]
- gi|14248372|dbj|BAB58760.1| (AP003365) pantoate beta-alanine ligase [Staphylococcus aureus subsp. aureus Mu50]
- gi|15791665|ref|NP_281488.1|_1:277 (NC_002163) pantoate--beta-alanine ligase [Campylobacter jejuni]
- gi|9978482|sp|Q9PIK2|PANC_CAMJE Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|11279935|pir||E81448 pantoate--beta-alanine ligase (EC 6.3.2.1) Cj0297c [imported] - Campylobacter jejuni (strain NCTC 11168)
- gi|6967771|emb|CAB72764.1| (AL139074) pantoate--beta-alanine ligase [Campylobacter jejuni subsp. jejuni NCTC 11168]
- gi|15614251|ref|NP_242554.1|_1:280 (NC_002570) pantothenate synthetase [Bacillus halodurans]
- gi|13431776|sp|Q9KC86|PANC_BACHD Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|10174305|dbj|BAB05407.1| (AP001512) pantothenate synthetase [Bacillus halodurans]
- gi|15599924|ref|NP_253418.1|_1:279 (NC_002516) pantoate--beta-alanine ligase [Pseudomonas aeruginosa]
- gi|13431775|sp|Q9HV69|PANC_PSEAE Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|11350723|pir||G83055 pantoate--beta-alanine ligase PA4730 [imported] - Pseudomonas aeruginosa (strain PAO1)
- gi|9950990|gb|AAG08116.1|AE004886_8 (AE004886) pantoate--beta-alanine ligase [Pseudomonas aeruginosa]
- gi|21399457|ref|NP_655442.1|_1:278 (NC_003995) Pantoate_ligase, Pantoate-beta-alanine ligase [Bacillus anthracis A2012] [Bacillus anthracis str. A2012]
- gi|16763571|ref|NP_459186.1|_1:279 (NC_003197) pantothenate synthetase [Salmonella typhimurium LT2]
- gi|16418683|gb|AAL19145.1| (AE008702) pantothenate synthetase [Salmonella typhimurium LT2]
- gi|15896168|ref|NP_349517.1|_1:277 (NC_003030) Pantoate--beta-alanine ligase [Clostridium acetobutylicum]
- gi|15025965|gb|AAK80857.1|AE007789_3 (AE007789) Pantoate--beta-alanine ligase [Clostridium acetobutylicum]
- gi|16759173|ref|NP_454790.1|_1:279 (NC_003198) pantoate:beta-alanine ligase [Salmonella enterica subsp. enterica serovar Typhi]
- gi|16501463|emb|CAD01335.1| (AL627265) pantoate:beta-alanine ligase [Salmonella enterica subsp. enterica serovar Typhi]
- gi|16803940|ref|NP_465425.1|_1:281 (NC_003210) similar to panthotenate synthetases [Listeria monocytogenes EGD-e]
- gi|16411354|emb|CAC99979.1| (AL591981) similar to panthotenate synthetases [Listeria monocytogenes]
- gi|16801081|ref|NP_471349.1|_1:281 (NC_003212) similar to panthotenate synthetases [Listeria innocua]
- gi|16414516|emb|CAC97245.1| (AL596170) similar to panthotenate synthetases [Listeria innocua]
- gi|21553665|gb|AAM62758.1|_3:307 (AY085534) pantoate-beta-alanine ligase [Arabidopsis thaliana]
- gi|16330757|ref|NP_441485.1|_2:286 (NC_000911) pantothenate synthetase/cytidylate kinase [Synechocystis sp. PCC 6803]
- gi|7470762|pir||S75604 pantothenate synthetase panC - Synechocystis sp. (strain PCC 6803)
- gi|1653250|dbj|BAA18165.1| (D90912) pantothenate synthetase/cytidylate kinase [Synechocystis sp. PCC 6803]
- gi|14285652|sp|O24035|PANC_LOTJA_3:306 Pantoate--beta-alanine ligase precursor (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|2292921|emb|CAA71302.1| (Y10252) pantoate--beta-alanine ligase [Lotus japonicus]
- gi|15239721|ref|NP_199695.1|_3:307 (NM_124261) pantoate-beta-alanine ligase [Arabidopsis thaliana]
- gi|20139170|sp|Q9FKB3|PANC_ARATH Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|9758883|dbj|BAB09437.1| (AB012242) pantoate-beta-alanine ligase [Arabidopsis thaliana]
- gi|21242531|ref|NP_642113.1|_2:278 (NC_003919) pantoate-beta-alanine ligase [Xanthomonas axonopodis pv. citri str. 306]
- gi|21107984|gb|AAM36649.1| (AE011810) pantoate-beta-alanine ligase [Xanthomonas axonopodis pv. citri str. 306]
- gi|21674465|ref|NP_662530.1|_1:281 (NC_002932) pantoate-beta-alanine ligase [Chlorobium tepidum TLS]
- gi|21647653|gb|AAM72872.1| (AE012920) pantoate-beta-alanine ligase [Chlorobium tepidum TLS]
- gi|12643468|sp|Q55073|PANC_SYNY3_1:281 Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|21231218|ref|NP_637135.1|_2:282 (NC_003902) pantoate-beta-alanine ligase [Xanthomonas campestris pv. campestris str. ATCC 33913]
- gi|21112863|gb|AAM41059.1| (AE012278) pantoate-beta-alanine ligase [Xanthomonas campestris pv. campestris str. ATCC 33913]
- gi|15676767|ref|NP_273912.1|_1:275 (NC_003112) pantoate--beta-alanine ligase [Neisseria meningitidis MC58]
- gi|9978476|sp|P57036|PANC_NEIMB Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|11279936|pir||G81148 pantoate--beta-alanine ligase NMB0871 [imported] - Neisseria meningitidis (group B strain MD58)
- gi|7226108|gb|AAF41282.1| (AE002439) pantoate--beta-alanine ligase [Neisseria meningitidis MC58]
- gi|15794037|ref|NP_283859.1|_1:275 (NC_003116) putative pantoate--beta-alanine ligase [Neisseria meningitidis Z2491]
- gi|9978473|sp|P57035|PANC_NEIMA Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|11279933|pir||F81874 probable pantoate--beta-alanine ligase (EC 6.3.2.1) NMA1089 [imported] - Neisseria meningitidis (group A strain Z2491)
- gi|7379784|emb|CAB84352.1| (AL162755) putative pantoate--beta-alanine ligase [Neisseria meningitidis Z2491]
- gi|15836835|ref|NP_297523.1|_3:279 (NC_002488) pantoate--beta-alanine ligase [Xylella fastidiosa 9a5c]
- gi|13431778|sp|Q9PGR8|PANC_XYLFA Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|11279932|pir||F82832 pantoate--beta-alanine ligase XF0230 [imported] - Xylella fastidiosa (strain 9a5c)
- gi|9105039|gb|AAF83043.1|AE003876_8 (AE003876) pantoate--beta-alanine ligase [Xylella fastidiosa 9a5c]
- gi|15616815|ref|NP_240027.1|_1:279 (NC_002528) pantoate-beta-alanine ligase [Buchnera sp. APS]
- gi|11133982|sp|P57292|PANC_BUCAI Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|10038878|dbj|BAB12913.1| (AP001118) pantoate-beta-alanine ligase [Buchnera sp. APS]
- gi|21672477|ref|NP_660544.1|_1:279 (NC_004061) pantoate--beta-alanine ligase [Buchnera aphidicola str. Sg (Schizaphis graminum)]
- gi|21623094|gb|AAM67755.1| (AE014095) pantoate--beta-alanine ligase [Buchnera aphidicola str. Sg (Schizaphis graminum)]
- gi|15644640|ref|NP_206808.1|_1:274 (NC_000915) pantoate-beta-alanine ligase (panC) [Helicobacter pylori 26695]
- gi|2498743|sp|P56061|PANC_HELPY Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|7449520|pir||F64520 pantoate--beta-alanine ligase (EC 6.3.2.1) - Helicobacter pylori (strain 26695)
- gi|2313083|gb|AAD07079.1| (AE000523) pantoate-beta-alanine ligase (panC) [Helicobacter pylori 26695]
- gi|16126405|ref|NP_420969.1|_4:282 (NC_002696) pantoate--beta-alanine ligase [Caulobacter crescentus CB15]
- gi|13423661|gb|AAK24137.1| (AE005888) pantoate--beta-alanine ligase [Caulobacter crescentus CB15]
- gi|15611077|ref|NP_222728.1|_1:274 (NC_000921) PANTOATE--BETA-ALANINE LIGASE [Helicobacter pylori J99]
- gi|8134632|sp|Q9ZN52|PANC_HELPJ Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|7449519|pir||H71985 pantoate--beta-alanine ligase (EC 6.3.2.1) - Helicobacter pylori (strain J99)
- gi|4154509|gb|AAD05590.1| (AE001440) PANTOATE--BETA-ALANINE LIGASE [Helicobacter pylori J99]
- gi|17547106|ref|NP_520508.1|_1:281 (NC_003295) PROBABLE PANTOATE--BETA-ALANINE LIGASE PROTEIN [Ralstonia solanacearum]
- gi|17429407|emb|CAD16094.1| (AL646069) PROBABLE PANTOATE--BETA-ALANINE LIGASE PROTEIN [Ralstonia solanacearum]
- gi|13470476|ref|NP_102045.1|_4:279 (NC_002678) pantoate-beta-alanine ligase [Mesorhizobium loti]
- gi|14021218|dbj|BAB47831.1| (AP002994) pantoate-beta-alanine ligase [Mesorhizobium loti]
- gi|19551364|ref|NP_599366.1|_8:277 (NC_003450) COG0414:Panthothenate synthetase [Corynebacterium glutamicum]
- gi|8134625|sp|Q9X713|PANC_CORGL Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|11279934|pir||T47120 pantoate--beta-alanine ligase (EC 6.3.2.1) [validated] - Corynebacterium glutamicum
- gi|4803659|emb|CAA65398.1| (X96580) pantoate--beta-alanine ligase [Corynebacterium glutamicum]
- gi|21322877|dbj|BAB97506.1| (AP005274) Panthothenate synthetase [Corynebacterium glutamicum ATCC 13032]
- gi|1174253|gb|AAA86660.1|_1:273 (U44896) pantothenate synthetase [Synechocystis sp.]
- gi|17230428|ref|NP_486976.1|_38:304 (NC_003272) pantothenate synthetase [Nostoc sp. PCC 7120]
- gi|17132030|dbj|BAB74635.1| (AP003591) pantothenate synthetase [Nostoc sp. PCC 7120]
- gi|15806183|ref|NP_294888.1|_9:272 (NC_001263) pantoate--beta-alanine ligase [Deinococcus radiodurans]
- gi|9978485|sp|Q9RV66|PANC_DEIRA Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|7473264|pir||G75430 pantoate--beta-alanine ligase - Deinococcus radiodurans (strain R1)
- gi|6458903|gb|AAF10737.1|AE001965_11 (AE001965) pantoate--beta-alanine ligase [Deinococcus radiodurans]
- gi|14285653|sp|O24210|PANC_ORYSA_4:309 Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|7449524|pir||T03924 probable pantoate--beta-alanine ligase (EC 6.3.2.1) - rice
- gi|2292978|emb|CAA71303.1| (Y10253) pantoate--beta-alanine ligase [Oryza sativa (japonica cultivar-group)]
- gi|8134626|sp|Q9X844|PANC_STRCO_5:331 Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|6322046|ref|NP_012121.1|_29:343 (NC_001141) Pan6p [Saccharomyces cerevisiae]
- gi|730270|sp|P40459|PANC_YEAST Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme)
- gi|626313|pir||S48389 probable membrane protein YIL145c - yeast (Saccharomyces cerevisiae)
- gi|557778|emb|CAA86133.1| (Z38059) orf, len: 345, CAI: 0.13, similar to PANC_ECOLI P31663 PANTOATE-BETA-ALANINE LIGASE [Saccharomyces cerevisiae]
- gi|14595008|emb|CAC43301.1|_29:369 (AJ298881) fusarium oxysporum panthotenate synthetase [Fusarium oxysporum]
- gi|3097217|emb|CAA18788.1|_4:191 (AL023093) pantoate--beta-alanine ligase [Mycobacterium leprae]
- gi|7481146|pir||T36071_5:196 probable pantoate-amino acid ligase - Streptomyces coelicolor (fragment)
- gi|12620558|gb|AAG60834.1|AF322012_139_4:274 (AF322013) ID308 [Bradyrhizobium japonicum]
- gi|19553882|ref|NP_601884.1|_3:257 (NC_003450) COG0414:Panthothenate synthetase [Corynebacterium glutamicum]
- gi|21325460|dbj|BAC00082.1| (AP005282) Panthothenate synthetase [Corynebacterium glutamicum ATCC 13032]
- gi|7481147|pir||T36394_1:170 probable pantoate-amino acid ligase - Streptomyces coelicolor (fragment)

              10        20        30           40        50          60
              |         |         |            |         |           |
   1 MTIPAFHPGELNVYSAPGDVADVSRALRLTGR...RVMLVPTMGALHEGHLALVRAAKRV..PGS
   2 ----------MRIIETIEEMKKFSEEMREKKK...TIGFVPTMGYLHEGHLSLVRRARA-..END
   3 ----------MRIIETIEEMKKFSEEMREKKK...TIGFVPTMGYLHEGHLSLVRRARA-..END
   4 -TIPAFHPGELNVYSAPGDVADVSRALRLTGR...RVMLVPTMGALHEGHLALVRAAKRV..PGS
   5 -----------LLFKKIKDLRNFLKNKRCEGK...EIGFVPTMGYLHEGHRQLIKLARM-..QND
   6 ----------MKVITKVAELRRALADVRNAEK...RIGFVPTMGYLHDGHLALISASRE-..HCD
   7 ----------MLIIETLPLLRQQIRRLRMEGK...RVALVPTMGNLHDGHMKLVDEAKA-..RAD
   8 ----------MLIIETLPLLRQQIRRLRMEGK...RVALVPTMGNLHDGHMKLVDEAKA-..RAD
   9 ----------MQVFADIAVLREQIKQIKREGR...RVAFVPTMGNLHEGHLTLVRKARE-..LAD
  10 ----------MRTISTIADLREALAEHRRAGR...SIGLVPTMGYLHVGHMELVRRAGS-..END
  11 ----------MQIIHTIEELRQALAPARQQGK...KIGFVPTMGYLHKGHLELVRRARV-..END
  12 ---RAVGGDPMRLVKTVAELRDAIAAFRRAGK...TIGFVPTMGFLHIGHLTLVARAKA-..END
  13 ----------MLIIETLPLLRQQIRRWRQEGK...RIALVPTMGNLHEGHMTLVDEAKT-..RAD
  14 -RQPAFNPGELNVYSTPRDVTNVSSALRHTGR...RVMLVPTMGALHNGHLALVRAAKRV..PGS
  15 ----------MRLVKTVAELRDAIAAFRRAGK...TIGFVPTMGFLHIGHLTLVARAKA-..END
  16 ----------MRQITDISQLKEAIKQYHSEGK...SIGFVPTMGFLHEGHLTLADKARQ-..END
  17 -----------KLITTVKEMQHIVKAAKRSGT...TIGFIPTMGALHDGHLTMVRESVS-..TND
  18 ----------MQVLKEKLLIHQQVDNWRKDGN...RIAFVPTMGNLHEGHFSLVREAKR-..HAE
  19 -----------KLITTVKEMQHIVKAAKRSGT...TIGFIPTMGALHDGHLTMVRESVS-..TND
  20 ----------MQVITSVKEAKQIVKDWKSHQL...SIGYVPTMGFLHDGHLSLVKHAKT-..-QD
  21 ----------MIVCTTISDLQAQLRIEREQKR...SVGFVPTMGYLHEGHLSLVKRAKE-..EHD
  22 ----------MNTVKTVRELRAAVARARSEGK...RIGFVPTMGNLHAGHAALVKKAGE-..RAD
  23 ----------MKIVTTVQEMQHITKELRASGK...SIGFVPTMGYLHEGHATLLRKARE-..ENE
  24 ----------MLIIETLPLLRQHIRRLRQEGK...RVALVPTMGNLHDGHMKLVDEAKA-..RAD
  25 ----------MEILHSISDVKKYIKQWKKEGL...TIGLVPTMGYLHDGHKSLIERASK-..END
  26 ----------MLIIETLPLLRQHIRRLRQEGK...RVALVPTMGNLHDGHMKLVDEAKA-..RAD
  27 ----------MLIIRNKQELKEVILKQKQANK...TIGFVPTMGFLHEGHMTLVSHARK-..ESD
  28 ----------MLIIRNRQELKEAILKQKKANK...TIGFVPTMGFLHEGHMTLVSHARK-..ETD
  29 ----------PEVIRDKDSMRKWSRAMRSQGK...TIGLVPTMGYLHEGHLSLVRQSLA-..LTD
  30 ----------VQVFRTIAGLQTYLRQAGR-GK...TVGLVPTMGSLHAGHGSLLKRAVA-..EMD
  31 ----------PMVISDKDEMRKWSRSMRSQGK...LIALVPTMGFLHEGHLSLVRDAHN-..HAD
  32 ----------PEVIRDKDSMRKWSRAMRSQGK...TIGLVPTMGYLHEGHLSLVRQSLA-..LTD
  33 ----------IQTLTDLSALRALVNGWKREGL...RVALVPTMGNLHAGHYSLVMLARQ-..YAD
  34 ----------MQIINDPAEMQKIAEKLRLQHQ...YIGVVMTMGALHEGHLSLVKLAKA-..HAG
  35 ----------MQVFRTIAGLQTYLRQAGR-GK...TVGLVPTMGSLHAGHGSLLKRAVA-..EMD
  36 ----------IQTITDLSALRALVTGWKREGL...RVALVPTMGNLHAGHYSLVMLARQ-..YAD
  37 ----------MQIIHTIRELRAWRKNAG----...KVAFVPTMGNLHEGHLALVREAKK-..RAD
  38 ----------MQIIHTIQELRAWRKNA----G...TVAFVPTMGNLHEGHLALVREAKK-..RAD
  39 -----------ETVTDLSRLRGIVADWRRQGL...RVALVPTMGNLHAGHFSLVMLARH-..YAD
  40 ----------MHIIKTIKVLYKEIKILKKSNK...KIGLVPTMGNLHDGHIKLILLAKK-..YSD
  41 ----------MNIIKNINLLEKKIKELKKKNK...IIGLVPTMGNLHDGHIKLILLAKK-..NVD
  42 ----------MRVLETIVALREYRKSLE---E...SVGFVPTMGALHKGHQSLIERSLK-..ENS
  43 ----------PIIVRTVAEMREHVRAWKAAGQ...RVAVVPTMGALHEGHLSLVRLAQQ-..HAE
  44 ----------MRALETIATLREYRKSLK---E...SVGFVPTMGALHRGHQSLIERSLK-..ENS
  45 ----------MKVISSIQELRDQLRGQ----N...RVAFVPTMGNLHEGHLSLMRLARQ-..HGD
  46 ----------PEVVNSVAALRAQVSDWRRDGL...RVAMVPTMGALHEGHLSLIRIARE-..KAE
  47 ---------------------QALIDALLHHK...SVGLVPTMGALHSGHASLVKAARA-..END
  48 ----------MQVFRTIAGLQTYLRQAGR-GK...TVGLVPTMGSLHAGHGSLLKRAVA-..EMD
  49 -----------------------------YQT...AIGLVPTMGSLHQGHLSLIERARH-..ENS
  50 -------------------------------G...RVGLVPTMGFLHEGHATLIRRARA-..ECD
  51 -------PREPEVIRDKAAMRAWSRRRRAEGK...TVAVVPTMGYLHQGHLSLISAAAAA..-AS
  52 --------TPPVLLRTAGELHARVRRGRR---...--AVVMTMGALHEGHATLIRTARDIagPDG
  53 --ILHIHIELMKIFHTVEEVVQWRTQELRETRfreTIGFVPTMGCLHSGHASLISQSVK-..ENT
  54 --LETLAKSPIRVLRSVEAVRRWRNPHVVNHR...SVGLVPTMGALHEGHLALIRAAAK-..ENH
  55 SRQPAFNPGELNVYSTPRDVTNVSSALRHTGR...RVMLVPTMGALHNGHLALVRAAKRV..PGS
  56 --------TPPVLLRTAGELHARVRRGRR---...--AVVMTMGALHEGHATLIRTARDIagPDG
  57 --------------TGLSAGKAFIREVARTGQ...TIGTVHTLGALHLGHAELIRRAAL-..END
  58 -----FTHGQGRVFDTVEQIRMFGSALRKTGK...PVVLVPLGNGLHAGHIALIRAAKR-..IPG
  59 --------------------------------...-------------------------..---


                  70           80        90              100           
                  |            |         |                |           
   1 ....VVVVSIFVNPMQF...GAGEDLDAYPRTPDDDLAQLRA..EG.....VEIAFTPT.....T
   2 ....VVVVSIFVNPTQF...GPNEDYERYPRDFERDRKLLEK..EN.....VDCIFHPS.....V
   3 ....VVVVSIFVNPTQF...GPNEDYERYPRDFERDRKLLEK..EN.....VDCVFHPS.....V
   4 ....VVVVSIFVNPMQF...GAGEDLDAYPRTPDDDLAQLRA..EG.....VEIAFTPT.....T
   5 ....IVVVSIFVNPTQF...GEGEDYDRYPRDLERDLEICEE..EG.....VDVVFAPE.....V
   6 ....VTVVSIFVNPTQF...GPNEDLSRYPRDFARDEALCGS..AG.....VSIIFAPS.....A
   7 ....VVVVSIFVNPMQF...DRPEDLARYPRTLQEDCEKLNK..RK.....VDLVFAPS.....V
   8 ....VVVVSIFVNPMQF...DRPEDLARYPRTLQEDCEKLNK..RK.....VDLVFAPS.....V
   9 ....VVVVSIFVNPMQF...DRAEDLKNYPRTLEEDLSKLNG..EG.....VDLVLTPT.....P
  10 ....VVVASIFVNPLQF...GANEDLGKYPRDLARDQALLTD..GG.....VDFLFAPG.....V
  11 ....VTLVSIFVNPLQF...GANEDLGRYPRDLERDAGLLHD..AQ.....VDYLFAPT.....V
  12 ....ATVVSIFVNPLQF...GANEDLARYPRDLARDSALLQE..AG.....VDILFAPD.....V
  13 ....VVVVTIFVNPLQF...ERPDDLAHYPRTLQEDCEKLTR..HG.....ADLVFAPA.....A
  14 ....VVVVSIFVNPLQF...GAAEDLDTYPCTFDDDLALLRA..ED.....VEIVFTPT.....A
  15 ....ATVVSIFVNPLQF...GANEDLARYPRDLARDSALLQE..AG.....VDILFAPD.....V
  16 ....AVIMSIFVNPAQF...GPNEDFEAYPRDIERDAALAEN..AG.....VDILFTPD.....A
  17 ....ITVVSVFVNPLQF...GPNEDFDAYPRQIDKDLELVSE..VG.....ADIVFHPA.....V
  18 ....KVVVSIFVNPMQF...NNPQDLLLYPRTMDQDCSQLQN..LG.....VDLVYAPT.....V
  19 ....ITVVSVFVNPLQF...GPNEDFDAYPRQIDKDLELVSE..VG.....ADIVFHPA.....V
  20 ....KVIVSIFVNPMQF...GPNEDFSSYPRDLERDIKMCQD..NG.....VDMVFIPD.....A
  21 ....TVVMSIFVNPLQF...GAGEDLDTYPRDFARDEQLAEA..EG.....VDILFYPS.....T
  22 ....FVVVSIFVNPLQF...GPSEDLDTYPRTLAADQERLLE..AG.....CHLLFTPT.....V
  23 ....IVVLSVFVNPLQF...GPNEDLDRYPRDIDRDENVAKE..NG.....VDYLFYPS.....V
  24 ....VVIVSIFVNPMQF...DRPDDLVRYPRTLQEDCEKLNK..RK.....VDYVFAPA.....V
  25 ....KVIVSDFVNPIQF...GPNEDLDVYPRDLDRDAEVCTK..AG.....ASILFNPE.....P
  26 ....VVIVSIFVNPMQF...DRPDDLVRYPRTLQEDCEKLNK..RK.....VDYVFAPA.....V
  27 ....FVVMSVFVNPTQF...GPNEDFDAYPRDEAHDAKLAEE..GG.....VDILFVPT.....V
  28 ....FVVMSVFVNPTQF...GPNEDFDAYPRDEAHDAKLAEE..GG.....VDILFVPT.....V
  29 ....VTVVSIYVNPGQF...SPTEDLSTYPSDFSGDLTKLAA..LS.....GGKVVVFN.....P
  30 ....LVVLSIFVNPLQF...GPGEDLEKYPRDFDGDRQWAES..LG.....VAVIFAPT.....V
  31 ....LVAVSIYVNPGQF...SPTEDLSAYPSDFQGDLQKLMSvpGG.....VDVVFHPHn24scV
  32 ....VTVVSIYVNPGQF...SPTEDLSTYPSDFSGDLTKLAA..LS.....GGKVVVFN.....P
  33 ....RVVSSVFVNPTQF...GPNEDFARYPRTPEADLRGLED..AG.....CDALWLPD.....V
  34 ....TVIMTIFVNPTQF...GPNEDFYRYPRPFEQDAALARS..AG.....VDYLFAPS.....T
  35 ....LVVLSIFVNPLQF...GPGEDLEKYPRDFDGDRQWAES..LG.....VAVIFAPT.....V
  36 ....RVVSSVFVNPTQF...GPNEDFARYPRTPEADMRGLED..AG.....CDALWLPD.....V
  37 ....SVVVSIFVNRLQF...GQGEDFDKYPRTLQQDADKLAA..EG.....IAVVFAPD.....E
  38 ....NVVVSIFVNRLQF...GQGEDFDKYPRTLQQDADKLEA..EG.....VAVVFAPD.....E
  39 ....RVVSSVFVNPTQF...GPHEDFRRYPRTPEADMRGLEH..VG.....CDVLWLPS.....V
  40 ....IIIVSIFINPMQF...DNLSDLKNYPKTFMKDSIILKK..YH.....VDILFFPH.....I
  41 ....IVIVSIFINPMQF...EDLLDLKKYPKTFEQDCCILKQ..EK.....VEILFCPD.....V
  42 ....HTIVSVFVNPTQF...GANEDFNAYPRPLEKDLALCEK..LG.....VNAVFVPK.....I
  43 ....RVIATVFVNPKQF...APHEDFDAYPRGEAADAEKLAL..VG.....CDLLFAPN.....A
  44 ....HTIVSVFVNPTQF...GANEDFSAYPRPLEKDLALCEK..SG.....VNAVFAPK.....I
  45 ....PVVASIFVNRLQF...GPNEDFDKYPRTLQADIEKLQK..EG.....VYVLFAPT.....E
  46 ....RCVVSIFVNPTQF...APSEDLDKYPRQLARDLDLLAR..VK.....ADLAFTPT.....V
  47 ....TVVASIFVNPLQFealGDCDDYRNYPRQLDADLALLEE..AG.....VDIVFAPD.....V
  48 ....LVVLSIFVNPLQF...GPGEDLEKYPRDFDGDRQWAES..LG.....VAVIFAPT.....V
  49 ....TVIVSIFINPLQF...GPNEDYGRYPRTLEQDRQLCEQ..GG.....VDAIFAPS.....P
  50 ....VVVVSIFVNPMQF...GPTEDLATYPRDLDRDLALAGA..AG.....ADFVFHPE.....A
  51 adpvAIVVTIYVNPSQF...APSEDLATYPSDFAGDLRKLAS..TGv....VDAVFNPPd20scL
  52 ....EVVVTVFVNPLQF...GAGEDLDRYPRTLDADLEIAGR..AG.....ADAVFAPA.....V
  53 ....YTVVSIFVNPSQF...APTEDLDNYPRTLPDDIKLLES..LK.....VDVLFAPN.....A
  54 ....HVVVSIYVNPAQF...GIKEDLSSYPVTWDEDAKKLAA..LDr12grISAVFAPT.....T
  55 ....VVVVSIFVNPLQF...GAAEDLDTYPCTFDDDLALLRA..ED.....VEIVFTPT.....A
  56 ....EVVVTVFVNPLQF...GAGEDLDRYPRTLDADLEIAGR..AG.....ADAVFAPA.....V
  57 ....VAIVTVYPNKIQL...RPG---GSYDFNLDDDIGLALR..SG.....ATAVISSS.....D
  58 ....AVVVVAYAGP---...-------------ESDHARLRE..EL.....IDAIFPFN.....P
  59 ....-------------...----------------------..--.....--------.....-


       110                  120        130       140       150       16
        |                    |          |         |         |         
   1 AAMYPD.G.....LR.....TTVQPG.PLAAELEGGPRPTHFAGVLTVVLKLLQIVRPDRVFFGE
   2 EEMYPP.D.....FS.....TYVEET.KLSKHLCGRSRPGHFRGVCTVVTKLFNIVKPHRAYFGQ
   3 EEMYPP.D.....FS.....TFVEET.KLSKPLCGRSRPGHFRGVCTVVTKLFNIVKPHRAYFGQ
   4 AAMYPD.G.....LR.....TTVQPG.PLAAELEGGPRPTHFAGVLTVVLKLLQIVRPDRVFFGE
   5 DEIYPK.G.....YR.....TKVCVG.ELGKVLEGEFRPGHFDGVATIVVKLFNIVQPNRAYFGE
   6 EEIYPA.Q.....FE.....SFVEPG.ELAKPLCGAFRPGHFRGVATVVCKLFNMVQPDVAYFGQ
   7 KEIYPN.G.....TEth...TYVDVP.GLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGE
   8 KEIYPN.G.....TEth...TYVDVP.GLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGE
   9 ETMYPQ.G.....LDkq...TFVEVP.GLSYMLEGASRPGHFRGVATIVTKLFNIVQPDVACFGE
  10 SDMYPR.P.....ME.....TVVDVP.KLGSELEGAVRPGHFAGVATVVTKLFNIVQPDRAYFGE
  11 SDMYPR.P.....MQ.....TVVDVP.PLGNQMEGEARPGHFAGVATVVSKLFNIVGPDAAYFGE
  12 TEMYPR.P.....IQ.....TVVDVP.ELGSQLEGAVRPGHFAGVTTVVTKLFNLVQPDAAYFGE
  13 ADIYPA.G.....LEkq...TYVDVP.ALSTILEGASRPGHFRGVSTIVSKLFNLIQPDVACFGE
  14 AAMYPH.G.....LR.....TTVRPG.ALAFELEGGPRPNHFDGVLTVVLKLLQIVRPDRVFFGE
  15 TEMYPR.P.....IQ.....TVVDVP.ELGSQLEGAVRPGHFAGVTTVVTKLFNLVQPDAAYFGE
  16 HDMYPG.E.....KN.....VTIHVE.RRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGL
  17 EDMYPG.E.....LG.....IDVKVG.PLADVLEGAKRPGHFDGVVTVVNKLFNIVMPDYAYFGK
  18 EELYPE.G.....SQdi...TFVDVP.KLSTMLEGASRPGHFRGVTTVVSKLFHIVNPDVACFGE
  19 EDIYPG.E.....LG.....IDVKVG.PLADVLEGAKRPGHFDGVVTVVNKLFNIVMPDYAYFGK
  20 TQMYLK.N.....FS.....TYVDMN.TITDKLCGAKRPGHFRGVCTVLTKFFNILNPDIVYMGQ
  21 DEMYPR.P.....AS.....VRLKVT.QGVDVLCGASRPGHFDGVVTVVLKLFHLVEPDAAYFGL
  22 EEMYPD.G.....MDgq...TRIHVP.GVSEGLCGASRPGHFEGVATVVSKLLNMVQPDLALFGE
  23 EEMYPA.E.....QT.....TTVEVV.KRTDVLCGKQRPGHFAGVATVLMKLFNITLPTRAYFGM
  24 EEIYPH.G.....LEgq...TYVDVP.GLSTMLEGASRPGHFRGVSTIVSKLFNLIQPDIACFGE
  25 SEMYFD.D.....AV.....TFVNSS.KITDILCGARRPGHFRGVCTVVTKLFNITCPDRAYFGE
  26 EEIYPQ.G.....LEgq...TYVDVP.GLSTMLEGTSRPGHFRGVSTIVSKLFNLIQPDIACFGE
  27 EEIYPT.E.....LS.....TKLHVD.KRVSVLDGADREGHFDGVVTVLTKLFHLVSPDNAYFGQ
  28 EEIYPT.E.....LA.....TKLHVI.KRVSVLDGADREGHFDGVVTVLTKLFHLVNPDNAYFGQ
  29 KNLYDY.Gg26lgHE.....TWIRVE.RLEKGLCGKSRPVFFRGVATIVTKLFNIVEPDVALFGK
  30 TDLGID.A.....KGdqt..TVLPPP.AMTEVLCGAHRPGHFQGVATIVTKLFTIVCPDVAYFGA
  31 DRRSGF.G.....HE.....TWVRAE.KLEKPLCGKSRPVFFRGVATIVTKLFNIVEPDVAVFGK
  32 KNLYDY.Gg26lgHE.....TWIRVE.RLEKGFCGKSRPVFFRGVATIVTKLFNIVEPDVALFGK
  33 DTMYPL.G.....TAla...TPIHAP.GVSDVLEGECRPGHFDGVCTVVARLFNQVQPDVAAFGK
  34 EAMYPD.G.....YS.....TSIDPG.PIATRFEGASRPGHFGGMVTVVVKLLGITRPHLAVFGE
  35 TDLGID.A.....KGdqt..TVLPPP.AMTEVLCGAHRPGHFQGVATIVTKLFTIVCPDVAYFGA
  36 DTMYPL.G.....TAla...TPIHAP.GVSDVLEGVCRPGHFDGVCTVVARLFNQVQPDVAAFGK
  37 KELYPNvE.....QR.....YNVEPP.NLQNELCGKFRPGHFRGVATVVSKLFHIVSPDIACFGK
  38 KELYPNvE.....QR.....YNVEPP.NLQNELCGKFRPGHFLGVATVVSKLFNIVAPDVACFGK
  39 ETMYPL.G.....TErt...VRLFVP.CVSDVLEGTFRPGHFEGVCTVVARLFNQVLPDVAVFGK
  40 NEIYPN.G.....IEhq...TFVEVI.KLSKILEGQSRPGHFRGVTTIITKLFNFIQPDFAFFGE
  41 NEMYPL.G.....LKnh...TYIDVP.KLSKIIEGKVRPGHFIGVTTIVCKLFNLIQPNFSFFGE
  42 GEMYPY.E.....AEqrl..KLYAPK.FLSSSLEGAMRKGHFDGVVQIVLKMFHLVNPTRAYFGK
  43 TEMYAP.G.....FS.....TLVSVS.GVSEPLEGAARPQFFGGVATVVAKLFIQSQADVAVFGE
  44 GEMYPY.E.....AKqrl..KLYAPA.FLSHSLEGAVRKGHFDGVVQVVLRLFHLTNPTRAYFGK
  45 RDMYPE.P.....QE.....YRVEPPhDLGDILEGEFRPGFFKGVCTVVMKLFSCVQPRVAVFGK
  46 GAMYPA.G.....FA.....TRISVG.GPSAGLESDFRPTFFEGVATVVAKLFLQATPDCAVFGE
  47 EEMYPG.G.....LPl....VWARTG.SIGTKLEGASRPGHFDGVATVVAKLFNLVRPDRAYFGQ
  48 TDLGID.A.....KGdqt..TVLPPP.AMTEVLCGAHRPGHFQGVATIVTKLFTIVCPDVAYFGA
  49 EELGIP.Q.....KNiq7vtQVIPPS.VMISGLCGHSRLGHFQGVATIVTKLLNLVQPDRAYFGQ
  50 AAMYPA.G.....FS.....TRVEVS.GVSEPLDGAARPGHFAGVATVVLKLLNIVQPERAYFGE
  51 EEAAGD.G.....HE.....TWVRVE.RLEKGLCGASRPVFFRGVATIVSKLFNIIEPDVPVFGK
  52 DEVYPG.G.....EPq....VRVTAG.PMGGRLEGASRPGHFDGMLTVVAKLLHLTRPDLALYGQ
  53 HVMYPQ.G.....IPld8kgPFVSVL.GLSEKLEGKTRPNFFRGVATVVTKLFNIVMADVAYFGQ
  54 PEMYPS.G.....FPgq8kgSFVTIT.PVGEVLEGASRPTFFRGVATVCLKLFNIVQPERVYFGQ
  55 AAMYPH.G.....LR.....TTVRPG.ALAFELEGGPRPNHFDGVLTVVLKLLQIVRPDRVFFGE
  56 DEVYPG.G.....EPq....VRVTAG.PMGGRLEGASRPGHFDGMLTVVAKLLHLTRPDLALYGQ
  57 TEMFPV.G.....YR.....TYVSQG.DCDLRLGGP--ETYLKEAVTGAIRWICYSRPTRSYFGL
  58 ETLWPH.G.....IR.....VEVT--.-------GGPTLTPQGAEVTKVLGLLGITGATDVVLGE
  59 ------.-.....--.....------.--------------------------------------


      0       170       180       190            200       210       22
     |         |         |         |              |         |         
   1 KDYQQLVLIRQLVADFNLDVAVVGVPTVREAD.....GLAMSSRNRYLDPAQRAAAVALSAALTA
   2 KDAQQFRVLRRMVRDLNMDVEMIECPIVREPD.....GLAMSSRNVYLSPEERQQALSLYQSLKI
   3 KDAQQFRVLRRMVRDLNMDVEMIECPIVREPD.....GLAMSSRNVYLTPEERKQALALYQSLKI
   4 KDYQQLVLIRQLVADFNLDVAVVGVPTVREAD.....GLAMSSRNRYLDPAQRAAAVALSAALTA
   5 KDYQQLKIIEQVVEDLNIPVEIVPVPIVREED.....GLAYSSRNVYLSPEERESALSIYKSFLL
   6 KDFQQCAVIRRMTVDLNLPIEIVTVPTVREPD.....GLAMSSRNRYLCPEERDRSLAISRGLFA
   7 KDFQQLALIRKMVADMGFDIEIVGVPIMRAKD.....GLALSSRNGYLTAEQRKIAPGLYKVLSS
   8 KDFQQLALIRKMVADMGFDIEIVGVPIMRAKD.....GLALSSRNGYLTAEQRKIAPGLYKVLSS
   9 KDFQQLAVIRQMVEDLCMDIEIVGVATVRELD.....GLAMSSRNNLLTLDERQRAPVLARTMRW
  10 KDFQQLQIIRRMVEDLAQPVTVIGVPTVREED.....GLACSSRNVYLTTQERRAAAIVPKALDE
  11 KDFQQLVIIRRMVDDMAIPVRIVGVETVREDD.....GLACSSRNVYLTPEQRRAAIIVPQALDE
  12 KDYQQVTLVRRMVEDLAQPVRVIPVATVREAD.....GLACSSRNVYLSPEQRAAAVIVPHALDE
  13 KDYQQLALIRKMVADMGYDINIVGVPTVRAKD.....GLALSSRNGYLTEEERQIAPQLSKIMWA
  14 KDYQQLVLIRQMVADLNVDVVVVGVPTVREVD.....GLAMSSRNCYLDPVQRDLAAALSAALTA
  15 KDYQQVTLVRRMVEDLAQPVRVIPVATVREAD.....GLACSSRNVYLSPEQRAAAVIVPHALDE
  16 KDAQQVAVVDGLISDFFMDIELVPVDTVREED.....GLAKSSRNVYLTAEERKEAPKLYRALQT
  17 KDAQQLAIVEQMVKDFNHAVEIIGIDIVREAD.....GLAKSSRNVYLTEQERQEAVHLSKSLLL
  18 KDFQQVAIIKKMVRDLNFFIEIIQVPIVRADD.....GLALSSRNGYLTSEERKIAPNLYKILKK
  19 KDAQQLAIVEQMVKDFNHAVEIIGIDIVREAD.....GLAKSSRNVYLTEQERQEAVHLSKSLLL
  20 KDAQQCVVVRHMVDDLNFDLKIQICPIIREED.....GLAKSSRNVYLSKEERKASLAISQSIFL
  21 KDAQQVAVITNMVEDLNVGVQIVPCATVREVD.....GLAKSSRNVRLSEKERKEAPGLYQSLLA
  22 KDFQQLAVIRKLVRDLNLPVQIFGEPTVRAAD.....GLALSSRNGYLDEQQRAAAPAIYRTLRQ
  23 KDAQQVAVIEGFVADFNIPVIIVPVDIVREED.....GLAKSSRNVYLSQKERKEAPHLYRSLCM
  24 KDFQQLALIRKMVADMSYDIEIVGVPIIRAKD.....GLALSSRNAYLTAEQRKIAPGLYNVMNS
  25 KDAQQVAVIKRMVRDLNFDIEIVACPIIREED.....GLAKSSRNSYLSSEERKAATILSKSLNL
  26 KDFQQLALIRKMVADMGYDIEIVGVPIIRAKD.....GLALSSRNAYLTAEQRKIAPGLYNVMNS
  27 KDAQQVAVVSGLVEDYFFPVNLRIIATVREAD.....GLAKSSRNVYLTEKERKEAPVIHEALQL
  28 KDAQQVAVVSGLVEDYFFPVNLRIIPTVREAD.....GLAKSSRNVYLTETERKEAPVIHAALQL
  29 KDYQQWRIIQRMVRDLNFGIEIVGSDIAREKD.....GLAMSSRNVRLSDEERQRALSISRSLAM
  30 KDAQQLAIIRRLVQDLNLTVTIRSCATVREES.....GLAMSSRNQYLSPIEKEQATVLYRSLQA
  31 KDYQQWKIIQRMVRDLDFSIKVIGSEVIREKD.....GLAMSSRNVYLSPEEREKAVSINKSLFR
  32 KDYQQWRIIQRMVRDLNFGIEIVGSDIAREKD.....GLAMSSRNVRLSDEERQRALSISRSLAM
  33 KDYQQLAVIRQMVADLAFPIEILGGSIVREAD.....GLAMSSRNQYLSAEDRPISSTIRKVLLQ
  34 KDAQQLAIIRRVVTDLNIGTTILGAPIVRESD.....GLATSSRNIYLSSNERQQATVLYRAIRY
  35 KDAQQLAIIRRLVQDLNLTVTIRSCATVREES.....GLAMSSRNQYLSPIEKEQATVLYRSLQA
  36 KDYQQLAVIRQMVADLAFPIEILGGSIVREAD.....GLAMSSRNQYLSADDRPISAQIRKVLLQ
  37 KDYQQLAVIKGFVEDLNFDVEIVPVDTGRAED.....GLALSSRNQYLSAAERDEAPRLYRELKA
  38 KDYQQLAVIKGLTEDLNFDVEIVPVDTGRAED.....GLALSSRNQYLSAAERDEAPRLYRELKA
  39 KDYQQLVVIRQMVVDLAFPIEILGGCIVRESD.....GLAMSSRNQYLSMQERPQAAEIHRTLIA
  40 KDYQQLLIIKILVKELNYMIKIISLPTIRLKN.....GLALSSRNNYLSSQENEIAPYLYKIIKK
  41 KDYQQLLIIKKLVKELNYPIKIISLPIIRLKN.....GLAFSSRNKHLSDLAQQKASYLYQAIKQ
  42 KDAQQLLIIEHLVKDLLLDIEIAPCEIVRDDD.....NLALSSRNVYLNATQRKQALAIPKALEK
  43 KDYQQLQVVRRMARDLDIPVEIIGAPTARAED.....GLALSSRNAYLSAEERAAAVALPTAMKA
  44 KDAQQLLIIQHLVQDLLLDIEIAPCEIVRDSD.....NLALSSRNVCLNATERKQALAIPKALEK
  45 KDYQQLMIVRRMANQFALPVDIIPAETVRAED.....GLALSSRNAYLSNEERAEAPELYRTLGQ
  46 KDYQQLCVVRQLCRDLDLPVEIIGAPTIRDAH.....GLAMSSRNAYLDEAELAVARRLNVILHK
  47 KDAQQVAVIRRLVADLDIPVEIRPVPIIRGAD.....GLAESSRNQRLSADQRAQALVLPQVLSG
  48 KDAQQLAIIRRLVQDLNLTVTIRSCATVREES.....GLAMSSRNQYLSPIEKEQATVLYRSLQA
  49 KDGQQLAVIKRLVADLDLPVEIVACPTVREAS.....GLACSSRNQYLTAQEKQQAAVLYRGLLQ
  50 KDWQQLAVVRRLVADLNLRSEIVGVPTVRADEeaahaGLALSSRNSYLSPEQQRRATVLSRALRA
  51 KDYQQWRVILPYWSGLDFGIEIMGSRNCARTD.....GLAMNSRNVHLSREEGKKALSISRSLVD
  52 KDAQQLALIRRMVRDLNFGVEIVGVPTVREED.....GLALSSRNRYLSTAERRTALALSQALFA
  53 KDIQQFIVLQCMVDELFVNTRLQMMPIVRNNN.....GLALSSRNKYLCPESLKISENLYRGLKA
  54 KDVQQTVVIRRMVKDFILPMEVVVEPTQRELD.....GLALSSRNVYLGPRRRAVATVLPHALFT
  55 KDYQQLVLIRQMVADLNVDVVVVGVPTVR---.....----------------------------
  56 KDAQQLALIRRMVRDLNFGVEIVGVPTVREED.....GLALSSRNRYL-----------------
  57 KDIGQAILVKRAVADLLLDCEIRFVPTVRYKN.....GVPISSRLRRFNRSELDELSCLFTALNR
  58 KDYELVVLVQRALNDLHIPVKLHSVPTVRMPD.....GLAISLRNISVPEDSRETALSLAAALTA
  59 --------IRRMVRDLNFGVEIVGVPTVREED.....GLALSSRNRYLSTAERRTALALSQALFA


      0                230       240                 250       260     
     |                  |         |                   |         |     
   1 AAHAAT....AGA.....QAALDAARAVLDAA.....P.....GVAVDYLELRDIGLGPM.....
   2 AENLYL....NGE.....RDAEKIKEEMIKHLsrf..D.....KVKIDYVEIVDEETLEPve...
   3 AENLFL....NGE.....RDAVKIKEAMINHLsrf..D.....RVKIDYVEIVDEETLEPve...
   4 AAHAAT....AGA.....QAALDAARAVLDAA.....P.....GVAVDYLELRDIGLGPM.....
   5 AEKMIK....AGE.....RDAKRIKEAIRAFIerhp.H.....VKGVDYVEITDQNLNPKe....
   6 AAHEFA....SGE.....RDAATLIALARRHLe....R.....VDRLQYLELVDPGTLRIads..
   7 IADKLQ....AGE.....RDLDEIIAIAGQELne...K.....GFRADDIQIRDADTLLEvs...
   8 IADKLQ....AGE.....RDLDEIITIAGQELne...K.....GFRADDIQIRDADTLLEvs...
   9 ISSAIR....GGR.....DDYPSIIEDAVDQLra...A.....DLEPDEIFIRDARTLLPis...
  10 AERLIA....SGV.....TEPAEVEKRVLEFLage..P.....LARPEVVALRDPETLGPvse..
  11 ADRLYR....SGM.....DDPDALEAAIRTFIgrq..P.....LAVPEVIAIRDPETLERlpa..
  12 AERLYA....EGV.....DDPAAIEAAIEKFIaae..P.....LASPEVVAVRDPDTLAPvas..
  13 LAEKMA....LGE.....RQIDALLEEAAAQLlr...V.....GFTPDELFIRDAETLQPlt...
  14 GAHAAT....GGA.....QAALDAARAVLDAT.....P.....GLVVDYVELRDAGLGPM.....
  15 AERLYA....EGV.....DDPAAIEAAIEKFIaae..P.....LASPEVVAVRDPDTLAPvas..
  16 SAELVQ....AGE.....RDPEAVIKAAKDIIet...T.....SGTIDYVELYSYPELEPvn...
  17 AQALYQ....DGE.....RQSKVIIDRVTEYLesh..I.....SGRIEEVAVYSYPQLVEqh...
  18 LAQELS....NGN.....GDLEKLIAETNTELsr...C.....RFIPDQLEICDSTTLEPft...
  19 AQALYQ....DGE.....RQSKVIIDRVTEYLesh..I.....SGRIEEVAVYSYPQLVEqh...
  20 AEKLVR....EGE.....KNTSKIIQAMKDILeke..K.....LIKIDYIELVDFNTMENie...
  21 GREALD....AGE.....KDAAVIRERIRQSLeer..L.....TGRIDYVEVLSYPRLQKie...
  22 LGERIR....AGA.....EDFPALLADARQALeq...A.....GLRPDYLEIREPISLRPgv...
  23 AKERIE....AGE.....RNAEIITTLVKEYIety..T.....KGTVDYADLYAYPSLQVvd...
  24 IAEKLI....AGN.....RELQEIIAIAEQELne...K.....GFRADDIQIRDADTLLElt...
  25 AKELLD....NGE.....KNVYNIKKAIIIEIgke..P.....LAKIDYVEVVDSLSLKSvs...
  26 IAEKLI....AGN.....RELQEIIAIAEQELne...K.....GFRADDIQIRDADTLLElt...
  27 GRKLIE....SGE.....TNQAKIVQMMTEKIneqt.S.....HELIAYLAIYSYPEFTPvt...
  28 GRQLID....SGE.....TDEAKIVQVMTDKIneqt.S.....HEKIAYLALYSYPEFTPvt...
  29 AKASVA....EGK.....TNCAELKDMIIQQVvg...S.....AGRVDYVEIVDQETLEGve...
  30 AQQRYR....QGD.....RQVSALLTATQDVLdae..P.....SVQVQYLQLVEADTLQPitgtl
  31 AKSAAE....DGQ.....IHCEKLINLVVQSIte...A.....GGRIDYAEIVDQNNLEKve...
  32 AKASVA....EGK.....TNCAELKDMIIQQVvg...S.....AGRVDYVEIVDQETLEGve...
  33 MRDSYA....AGT.....PRAQVEDAASHTLEq....A.....GFRVDYAVVRLPDLSEPgd...
  34 AKMEID....KDR.....TDLEAIAGEAEALVrse..P.....DAEPDYLCFVDDATFEPvtqa.
  35 AQQRYR....QGD.....RQVSALLTATQDVLdae..P.....SVQVQYLQLVEADTLQPitgtl
  36 MRDSHA....AGV.....PRLQVEAAATQALEa....V.....GFRVDYTALRLPDLSEPdd6sn
  37 VAESLV....QGS.....LDYAGLEKRAVQSLte...Y.....GWVVDYVEIRRADTLEVar...
  38 VAESLA....QGS.....LDYAGLEKRAVQSLte...Y.....GWVVDYVEIRRVDTLEVar...
  39 MRDAVM....SGG.....VHADVEAEAVRRLEa....A.....GFQVDYAVIRLSDLGEPidg..
  40 TCEKII....KED.....DNIRPKIIHESKILlik..K.....GFSVDIFDIYDYKNLEHps...
  41 TCNFIK....NNNg....KNIKKNIHTSRKYLik...K.....GFYIDIFNAYDSKTLDPis...
  42 IQQAID....KGE.....KACEKLKKLGLEIL.....E.....TLEVDYLECCNHKLEPLti...
  43 AAAAVA....QGGpi...EDAERSAVAALQAA.....G.....FGQVDYVEIREASDLSRlgpgp
  44 IQQAID....RGE.....KACEKLKKLGLEIL.....K.....NLEVDYLECCNHKLEPLkt...
  45 VRQTMLetvlQGQ.....ASVEEVTAKALEHLrg...R.....GWQPDYVAVRRRSDLQPpt6ni
  46 AAAALA....AGT.....HQDDATGEANRALIaa...G.....FQKIDYVEARESLTLAPw....
  47 LQRRKA....AGE.....ALDIQGARDTLASA.....D.....GVRLDHLEIVDPATLEPleidg
  48 APTAIS....SRR.....SPSFCFVDRHPGRFg....R.....GTVLSRCNICNWWKLTPcq...
  49 AEAAFK....AGV.....RYSSRLREVVRQELakv..S.....SVLVEYIELVEPTTLMPld...
  50 VQAAYA....GGE.....RDTGRLRQAGLDVLase..P.....ELALDYLVVVGPDLRDVpql..
  51 ARTGAL....KGN.....TDSKQIKNKIVQTLte...T.....GGQVDYVEIVEQESLVPve...
  52 GLDRHA....AQEa45av---RDAARLVLDDAarat.P.....PLELDYLALVDPSDFTEigd..
  53 AENAIRrlapGGR.....LSRSEIIDTVTQIWap6dsH.....DFKIDYVSLADFKTLDEls7nt
  54 AADVYNt...KAS.....RKREDILGAAYNFIda7rq-st9rvLFEVDYISLADPETLVEidev.
  55 ------....---.....--------------.....-.....-----------------.....
  56 ------....---.....--------------.....-.....-----------------.....
  57 SREEIA....RGA.....SSVKDLVASATSRIef...R.....QFRLEFVRIVDADNFKDle...
  58 GAHSAE....HGE.....AVVKETVTQVLKAA.....-.....GVTPDYVEIRGLDLGPA.....
  59 GLDRHA....AQEa45av---RDAARLVLDDAarat.P.....PLELDYLALVDPSDFTEigd..


             270                 280       290       300         
              |                   |         |         |         
   1 PLNGSGRLLVAARL.....GT.....TRLLDNIAIEIGTFAGTDRPDGYRAILESHWRN
   2 KIDRKVIVAVAAWV.....GN.....ARLIDNTI-------------------------
   3 KIDRKVIVAVAAWV.....GK.....ARLIDNTI-------------------------
   4 PLNGSGRLLVAARL.....GT.....TRLLDNIAIEIGTFAGTDRPDGYRAILESHWR-
   5 TVEKGDRILVAVRV.....GN.....ARLIDNW--------------------------
   6 PLRYPAVLCVAAYV.....GS.....TRLIDNVVLS-----------------------
   7 ETSKRAVILVAAWL.....GD.....ARLIDNKMV------------------------
   8 ETSKRAVILVAAWL.....GD.....ARLIDNKMV------------------------
   9 SESKQAVILMSAFL.....GK.....VRLIDNQVLDLQT--------------------
  10 IEEKPVLLLLFVRF.....GT.....TKLLDNRVI------------------------
  11 LQGRPILVALFVRV.....GA.....TRLLDNRVIG-----------------------
  12 LQAGPVLVALFVRF.....GS.....TRLLDNRVIGRE---------------------
  13 VDSQQAVILMAAWL.....GK.....ARLIDNQLV------------------------
  14 RDNTFGRLLVAARL.....GA.....TRLLDNISIEIGNFSGIASPDEC----------
  15 LQAGPVLVALFVRF.....GS.....TRLLDNRVIGRE---------------------
  16 EIAGKMILAVAVAF.....SK.....ARLIDNIIIDIR---------------------
  17 EITGRIFISLAVKF.....SK.....ARLIDNIII------------------------
  18 AGTKNVVILAAAWL.....GK.....ARLIDNI--------------------------
  19 EITGRIFISLAVKF.....SK.....ARLIDNIII------------------------
  20 NITDNVLGAVAAFV.....GK.....TRLIDNFL-------------------------
  21 RIEETVILAVAYQF.....EN.....ARLIDNLIVP-----------------------
  22 PGDRQLVILAAAYL.....GS.....TRLIDNLS-------------------------
  23 QIEGRIILAIAVKF.....EN.....VRLIDNIT-------------------------
  24 ETSKRAVILAAAWL.....GQ.....ARLIDNQS-------------------------
  25 KVQQSILVAIAVYI.....GK.....IRLIDNF--------------------------
  26 ETSKRAVILAAAWL.....GQ.....ARLIDNQS-------------------------
  27 DWSKGIIIAAAVKY.....SK.....ARLIDNELIN-----------------------
  28 DWTKGIIIAAAVKY.....SK.....ARLIDNELIN-----------------------
  29 EIKSGVVICVAAWF.....GT.....VRLIDNIEIN-----------------------
  30 PDQNPVLMAIAAYV.....GS.....TRLIDNLVLN-----------------------
  31 WIKGPVVFCVSAWF.....GK.....ARLIDNIEI------------------------
  32 EIKSGVVICVAAWF.....GT.....VRLIDNIEIN-----------------------
  33 SHAGARVALIAARL.....GN.....TRLIDNL--------------------------
  34 VTGKAYRLIMAVRI.....GS.....TRLIDNWRF------------------------
  35 PDQNPVLMAIAAYV.....GS.....TRLIDN---------------------------
  36 PAAGPRVALIAARI.....GS.....TRLIDNL--------------------------
  37 AGDKKLVVLAAACL.....GT.....TRLIDNLEI------------------------
  38 AGDKKLVVLAAARL.....GT.....TRLIDNLEI------------------------
  39 TVISPGIALVAARL.....GN.....TRLIDNL--------------------------
  40 KKVKKVILLASVWL.....GN.....TRLIDNK--------------------------
  41 KDSKNIIIIASVWL.....GK.....IRLIDNK--------------------------
  42 IEPTNTLILVAARV.....GK.....TRLLDNL--------------------------
  43 IGEASGRILVAAWL.....GK.....TRLIDNM--------------------------
  44 IEPANTLVLVAARV.....GK.....TRLLDNL--------------------------
  45 AAGEPLVVLTAAKL.....GK.....TRLIDNL--------------------------
  46 RRDRAGRVLAAAWL.....GK.....TRLIDNVD-------------------------
  47 LLTQPALVVGAIFV.....GP.....VRLIDNI--------------------------
  48 PITWNITGPKSCFN.....GD.....RRL------------------------------
  49 KIQEEGMLAIAARL.....GS.....TRLIDNTIL------------------------
  50 SDDPLNRVLIAGRL.....FG.....VRLIDNMPL------------------------
  51 QIDGPVVICVAAWF.....GK.....VRLIDNIEI------------------------
  52 DHTGEAVLAVAARV.....GA.....TRLIDNVHLTFG---------------------
  53 SEQQPIVISCAVYV.....TDre7tvVRLIDNI--------------------------
  54 DPSRGAVMSAAIKMl17ggPA.....VRLIDNIILKP----------------------
  55 --------------.....--.....---------------------------------
  56 --------------.....--.....---------------------------------
  57 QVKLPFLIIGAAMA.....HG.....LTVSDSIYVPD----------------------
  58 PEIGDARLFAAITL.....GD.....VQLHDNVGLPL----------------------
  59 DHTGEAVLAVAARV.....GA.....TRLIDNVHLTFG---------------------