(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0146 ygfZ, E.coli
    • gi|16766349|ref|NP_461964.1|_3:326 (NC_003197) putative aminomethyltransferase [Salmonella typhimurium LT2]
    • gi|16421599|gb|AAL21923.1| (AE008840) putative aminomethyltransferase [Salmonella typhimurium LT2]
    • gi|16761829|ref|NP_457446.1|_3:326 (NC_003198) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]
    • gi|16504131|emb|CAD02878.1| (AL627277) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]
    • gi|16130800|ref|NP_417374.1|_3:326 (NC_000913) orf, hypothetical protein [Escherichia coli K12]
    • gi|2506738sp|P39179|UP14_ECOLI Unknown protein from 2D-page (Spot PR51)
    • gi|7466478|pir||B65074 hypothetical protein b2898 - Escherichia coli (strain K-12)
    • gi|887848|gb|AAA83079.1| (U28375) ORF_o326 [Escherichia coli]
    • gi|1789265|gb|AAC75936.1| (AE000373) orf, hypothetical protein [Escherichia coli K12]
    • gi|15803434|ref|NP_289467.1|_3:326 (NC_002655) orf, hypothetical protein [Escherichia coli O157:H7 EDL933]
    • gi|15833024|ref|NP_311797.1| (NC_002695) hypothetical protein [Escherichia coli O157:H7]
    • gi|12517426|gb|AAG58026.1|AE005520_4 (AE005520) orf, hypothetical protein [Escherichia coli O157:H7 EDL933]
    • gi|13363242|dbj|BAB37193.1| (AP002563) hypothetical protein [Escherichia coli O157:H7]
    • gi|16121204|ref|NP_404517.1|_10:328 (NC_003143) conserved hypothetical protein [Yersinia pestis]
    • gi|15978970|emb|CAC89743.1| (AJ414145) conserved hypothetical protein [Yersinia pestis]
    • gi|21623327|gb|AAM67965.1|_12:317 (AE014118) unknown protein from 2d-page (spot pr51) [Buchnera aphidicola str. Sg (Schizaphis graminum)]
    • gi|15617034|ref|NP_240247.1|_12:317 (NC_002528) hypothetical protein [Buchnera sp. APS]
    • gi|11387298sp|P57510|Y435_BUCAI Hypothetical protein BU435
    • gi|10039099|dbj|BAB13133.1| (AP001119) hypothetical protein [Buchnera sp. APS]
    • gi|16130807|ref|NP_417381.1|_27:346 (NC_000913) aminomethyltransferase (T protein; tetrahydrofolate-dependent) of glycine cleavage system [Escherichia coli K12]
    • gi|121086sp|P27248|GCST_ECOLI Aminomethyltransferase (Glycine cleavage system T protein)
    • gi|1360976|pir||A56689 aminomethyltransferase (EC 2.1.2.10) [validated] - Escherichia coli
    • gi|148040|gb|AAC36843.1| (M97263) T-protein [Escherichia coli]
    • gi|403343|emb|CAA52144.1| (X73958) aminomethyltransferase [Escherichia coli]
    • gi|882435|gb|AAA69073.1| (U28377) ORF_f364 [Escherichia coli]
    • gi|1789272|gb|AAC75943.1| (AE000374) aminomethyltransferase (T protein; tetrahydrofolate-dependent) of glycine cleavage system [Escherichia coli K12]
    • gi|20806817|ref|NP_621988.1|_35:330 (NC_003869) Glycine cleavage system T protein (aminomethyltransferase) [Thermoanaerobacter tengcongensis]
    • gi|20515282|gb|AAM23592.1| (AE013002) Glycine cleavage system T protein (aminomethyltransferase) [Thermoanaerobacter tengcongensis]
    • gi|15803440|ref|NP_289473.1|_27:346 (NC_002655) aminomethyltransferase (T protein; tetrahydrofolate-dependent) of glycine cleavage system [Escherichia coli O157:H7 EDL933]
    • gi|15833030|ref|NP_311803.1| (NC_002695) aminomethyltransferase [Escherichia coli O157:H7]
    • gi|12517432|gb|AAG58032.1|AE005520_10 (AE005520) aminomethyltransferase (T protein; tetrahydrofolate-dependent) of glycine cleavage system [Escherichia coli O157:H7 EDL933]
    • gi|13363248|dbj|BAB37199.1| (AP002563) aminomethyltransferase [Escherichia coli O157:H7]
    • gi|16761836|ref|NP_457453.1|_27:346 (NC_003198) aminomethyltransferase [Salmonella enterica subsp. enterica serovar Typhi]
    • gi|16766356|ref|NP_461971.1| (NC_003197) glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent [Salmonella typhimurium LT2]
    • gi|16421606|gb|AAL21930.1| (AE008840) glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent [Salmonella typhimurium LT2]
    • gi|16504138|emb|CAD02885.1| (AL627277) aminomethyltransferase [Salmonella enterica subsp. enterica serovar Typhi]
    • gi|15828181|ref|NP_302444.1|_23:333 (NC_002677) conserved hypothetical protein [Mycobacterium leprae]
    • gi|13093735|emb|CAC31158.1| (AL583924) conserved hypothetical protein [Mycobacterium leprae]
    • gi|699212|gb|AAA62976.1|_16:326 (U15182) u2266f [Mycobacterium leprae]
    • gi|16079513|ref|NP_390337.1|_27:322 (NC_000964) similar to aminomethyltransferase [Bacillus subtilis]
    • gi|1730258sp|P54378|GCST_BACSU Probable aminomethyltransferase (Glycine cleavage system T protein)
    • gi|7450598|pir||H69958 aminomethyltransferase homolog yqhI - Bacillus subtilis
    • gi|1303890|dbj|BAA12546.1| (D84432) YqhI [Bacillus subtilis]
    • gi|2634891|emb|CAB14388.1| (Z99116) similar to aminomethyltransferase [Bacillus subtilis]
    • gi|15642468|ref|NP_232101.1|_5:322 (NC_002505) conserved hypothetical protein [Vibrio cholerae]
    • gi|11354709|pir||B82071 conserved hypothetical protein VC2472 [imported] - Vibrio cholerae (group O1 strain N16961)
    • gi|9657051|gb|AAF95614.1| (AE004317) conserved hypothetical protein [Vibrio cholerae]
    • gi|15607951|ref|NP_215326.1|_16:333 (NC_000962) hypothetical protein Rv0811c [Mycobacterium tuberculosis H37Rv]
    • gi|15840223|ref|NP_335260.1| (NC_002755) conserved hypothetical protein [Mycobacterium tuberculosis CDC1551]
    • gi|7476507|pir||C70809 hypothetical protein Rv0811c - Mycobacterium tuberculosis (strain H37RV)
    • gi|2916869|emb|CAA17617.1| (AL022004) hypothetical protein Rv0811c [Mycobacterium tuberculosis H37Rv]
    • gi|13880380|gb|AAK45074.1| (AE006973) conserved hypothetical protein [Mycobacterium tuberculosis CDC1551]
    • gi|17546501|ref|NP_519903.1|_12:340 (NC_003295) CONSERVED HYPOTHETICAL PROTEIN [Ralstonia solanacearum]
    • gi|17428799|emb|CAD15484.1| (AL646066) CONSERVED HYPOTHETICAL PROTEIN [Ralstonia solanacearum]
    • gi|21325353|dbj|BAB99974.1|_45:332 (AP005282) Predicted aminomethyltransferase related to GcvT [Corynebacterium glutamicum ATCC 13032]
    • gi|19553777|ref|NP_601779.1|_51:338 (NC_003450) COG0354:Predicted aminomethyltransferase related to GcvT [Corynebacterium glutamicum]
    • gi|15615379|ref|NP_243682.1|_29:323 (NC_002570) aminomethyltransferase [Bacillus halodurans]
    • gi|11132403sp|Q9K934|GCST_BACHD Probable aminomethyltransferase (Glycine cleavage system T protein)
    • gi|10175437|dbj|BAB06535.1| (AP001516) aminomethyltransferase [Bacillus halodurans]
    • gi|16272414|ref|NP_438627.1|_5:280 (NC_000907) conserved hypothetical protein [Haemophilus influenzae Rd]
    • gi|1175250sp|P44000|Y466_HAEIN Hypothetical protein HI0466
    • gi|1074413|pir||I64007 hypothetical protein HI0466 - Haemophilus influenzae (strain Rd KW20)
    • gi|1573444|gb|AAC22125.1| (U32729) conserved hypothetical protein [Haemophilus influenzae Rd]
    • gi|15603739|ref|NP_246813.1|_11:293 (NC_002663) unknown [Pasteurella multocida]
    • gi|12722304|gb|AAK03958.1| (AE006225) unknown [Pasteurella multocida]
    • gi|17231547|ref|NP_488095.1|_21:318 (NC_003272) glycine cleavage T-protein; aminomethyltransferase [Nostoc sp. PCC 7120]
    • gi|17133190|dbj|BAB75754.1| (AP003595) glycine cleavage T-protein; aminomethyltransferase [Nostoc sp. PCC 7120]
    • gi|6705950|dbj|BAA89441.1|_21:312 (AB003158) ORF4 [Corynebacterium ammoniagenes]
    • gi|7299068|gb|AAF54268.1|_23:339 (AE003680) CG8043 gene product [Drosophila melanogaster]
    • gi|15600408|ref|NP_253902.1|_27:336 (NC_002516) glycine-cleavage system protein T1 [Pseudomonas aeruginosa]
    • gi|11348638|pir||G82994 glycine-cleavage system protein T1 PA5215 [imported] - Pseudomonas aeruginosa (strain PAO1)
    • gi|9951522|gb|AAG08600.1|AE004934_7 (AE004934) glycine-cleavage system protein T1 [Pseudomonas aeruginosa]
    • gi|15595956|ref|NP_249450.1|_4:307 (NC_002516) conserved hypothetical protein [Pseudomonas aeruginosa]
    • gi|11347702|pir||G83549 conserved hypothetical protein PA0759 [imported] - Pseudomonas aeruginosa (strain PAO1)
    • gi|9946647|gb|AAG04148.1|AE004511_1 (AE004511) conserved hypothetical protein [Pseudomonas aeruginosa]
    • gi|21288138|gb|EAA00459.1|_35:362 (AAAB01008986) agCP9351 [Anopheles gambiae str. PEST]
    • gi|20346967|ref|XP_109887.1|_34:335 (XM_109887) similar to CG8043 gene product [Mus musculus]
    • gi|20880858|ref|XP_126451.1| (XM_126451) similar to CG8043 gene product [Mus musculus]
    • gi|15963857|ref|NP_384210.1|_438:739 (NC_003047) PUTATIVE AMINOMETHYLTRANSFERASE PROTEIN [Sinorhizobium meliloti]
    • gi|15073032|emb|CAC41491.1| (AL591782) PUTATIVE AMINOMETHYLTRANSFERASE PROTEIN [Sinorhizobium meliloti]
    • gi|15219844|ref|NP_176295.1|_89:388 (NM_104780) hypothetical protein [Arabidopsis thaliana]
    • gi|12323347|gb|AAG51655.1|AC018908_21 (AC018908) hypothetical protein; 60474-57856 [Arabidopsis thaliana]
    • gi|16331555|ref|NP_442283.1|_8:286 (NC_000911) unknown protein [Synechocystis sp. PCC 6803]
    • gi|7469610|pir||S76507 hypothetical protein - Synechocystis sp. (strain PCC 6803)
    • gi|1001622|dbj|BAA10353.1| (D64002) ORF_ID:slr0635~unknown protein [Synechocystis sp. PCC 6803]
    • gi|21402278|ref|NP_658263.1|_29:349 (NC_003995) GCV_T, G cleavage T-protein (aminomethyl transferase) [Bacillus anthracis A2012] [Bacillus anthracis str. A2012]
    • gi|20479074|ref|XP_114152.1|_33:332 (XM_114152) similar to CG8043 gene product [Homo sapiens]
    • gi|15892621|ref|NP_360335.1|_5:319 (NC_003103) unknown [Rickettsia conorii]
    • gi|15619789|gb|AAL03236.1| (AE008628) unknown [Rickettsia conorii]
    • gi|13476081|ref|NP_107651.1|_30:331 (NC_002678) similar to aminomethyltransferase [Mesorhizobium loti]
    • gi|14026841|dbj|BAB53437.1| (AP003011) similar to aminomethyltransferase [Mesorhizobium loti]
    • gi|15604328|ref|NP_220844.1|_5:261 (NC_000963) unknown [Rickettsia prowazekii]
    • gi|7467766|pir||F71705 hypothetical protein RP464 - Rickettsia prowazekii
    • gi|3861020|emb|CAA14920.1| (AJ235271) unknown [Rickettsia prowazekii]
    • gi|21222578|ref|NP_628357.1|_22:307 (NC_003888) conserved hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|8388730|emb|CAB94085.1| (AL358692) conserved hypothetical protein [Streptomyces coelicolor A3(2)]
    • gi|15597638|ref|NP_251132.1|_32:365 (NC_002516) glycine cleavage system protein T2 [Pseudomonas aeruginosa]
    • gi|11348637|pir||A83341 glycine cleavage system protein T2 PA2442 [imported] - Pseudomonas aeruginosa (strain PAO1)
    • gi|9948489|gb|AAG05830.1|AE004671_6 (AE004671) glycine cleavage system protein T2 [Pseudomonas aeruginosa]
    • gi|17507269|ref|NP_492346.1|_12:290 (NM_059945) S.pombe hypothetical protein C21E11.07 like [Caenorhabditis elegans]
    • gi|7503023|pir||T22009 hypothetical protein F39H2.3 - Caenorhabditis elegans
    • gi|3876970|emb|CAB03089.1| (Z81080) Similarity to S.pombe hypothetical protein C21E11.07 (SW:YAL7_SCHPO) [Caenorhabditis elegans]
    • gi|3878355|emb|CAB03184.1| (Z81098) Similarity to S.pombe hypothetical protein C21E11.07 (SW:YAL7_SCHPO) [Caenorhabditis elegans]
    • gi|15794366|ref|NP_284188.1|_3:260 (NC_003116) hypothetical protein NMA1464 [Neisseria meningitidis Z2491]
    • gi|11282832|pir||D81837 hypothetical protein NMA1464 [imported] - Neisseria meningitidis (group A strain Z2491)
    • gi|7380114|emb|CAB84698.1| (AL162756) hypothetical protein NMA1464 [Neisseria meningitidis Z2491]
    • gi|17987565|ref|NP_540199.1|_8:270 (NC_003317) AMINOMETHYLTRANSFERASE [Brucella melitensis]
    • gi|17983269|gb|AAL52463.1| (AE009566) AMINOMETHYLTRANSFERASE [Brucella melitensis]
    • gi|17560118|ref|NP_504502.1|_54:366 (NM_072101) aminomethytransferase [Caenorhabditis elegans]
    • gi|7499783|pir||T25732 hypothetical protein F25B4.1 - Caenorhabditis elegans
    • gi|1458286|gb|AAB37080.1| (U64842) Hypothetical protein F25B4.1 [Caenorhabditis elegans]
    • gi|15676912|ref|NP_274058.1|_3:255 (NC_003112) conserved hypothetical protein [Neisseria meningitidis MC58]
    • gi|11282831|pir||G81129 conserved hypothetical protein NMB1024 [imported] - Neisseria meningitidis (group B strain MD58)
    • gi|7226264|gb|AAF41424.1| (AE002453) conserved hypothetical protein [Neisseria meningitidis MC58]
    • gi|19115416|ref|NP_594504.1|_6:313 (NC_003424) hypothetical protein [Schizosaccharomyces pombe]
    • gi|1351677sp|Q09929|YAL7_SCHPO Hypothetical protein C21E11.07 in chromosome I
    • gi|2130309|pir||S62592 hypothetical protein SPAC21E11.07 - fission yeast (Schizosaccharomyces pombe)
    • gi|7490938|pir||T38139 hypothetical protein SPAC21E11.07 - fission yeast (Schizosaccharomyces pombe)
    • gi|1067223|emb|CAA91966.1| (Z67999) hypothetical protein [Schizosaccharomyces pombe]
    • gi|15888395|ref|NP_354076.1|_6:257 (NC_003062) AGR_C_1943p [Agrobacterium tumefaciens] [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17934960|ref|NP_531750.1| (NC_003304) glycine cleavage system T protein, aminomethyltransferase [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15156077|gb|AAK86861.1| (AE008035) AGR_C_1943p [Agrobacterium tumefaciens str. C58 (Cereon)]
    • gi|17739445|gb|AAL42066.1| (AE009069) glycine cleavage system T protein, aminomethyltransferase [Agrobacterium tumefaciens str. C58 (U. Washington)]
    • gi|15426168|emb|CAB98429.3|_5:331 (AL390114) possible hypothetical 36.9 Kd protein c21e11.07 in chromosome I [Leishmania major]
    • gi|21231578|ref|NP_637495.1|_9:263 (NC_003902) conserved hypothetical protein [Xanthomonas campestris pv. campestris str. ATCC 33913]
    • gi|21113265|gb|AAM41419.1| (AE012320) conserved hypothetical protein [Xanthomonas campestris pv. campestris str. ATCC 33913]
    • gi|15965302|ref|NP_385655.1|_33:333 (NC_003047) PROBABLE AMINOMETHYLTRANSFERASE (GLYCINE CLEAVAGE SYSTEM T PROTEIN) [Sinorhizobium meliloti]
    • gi|15074482|emb|CAC46128.1| (AL591787) PROBABLE AMINOMETHYLTRANSFERASE (GLYCINE CLEAVAGE SYSTEM T PROTEIN) [Sinorhizobium meliloti]
    • gi|21242812|ref|NP_642394.1|_9:263 (NC_003919) conserved hypothetical protein [Xanthomonas axonopodis pv. citri str. 306]
    • gi|21108298|gb|AAM36930.1| (AE011843) conserved hypothetical protein [Xanthomonas axonopodis pv. citri str. 306]
    • gi|15805387|ref|NP_294081.1|_2:292 (NC_001263) conserved hypothetical protein [Deinococcus radiodurans]
    • gi|7471756|pir||H75528 conserved hypothetical protein - Deinococcus radiodurans (strain R1)
    • gi|6458035|gb|AAF09938.1|AE001896_3 (AE001896) conserved hypothetical protein [Deinococcus radiodurans]
    • gi|15964857|ref|NP_385210.1|_2:261 (NC_003047) CONSERVED HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
    • gi|15074036|emb|CAC45683.1| (AL591786) CONSERVED HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
    • gi|13476462|ref|NP_108032.1|_5:266 (NC_002678) hypothetical protein [Mesorhizobium loti]
    • gi|14027223|dbj|BAB54177.1| (AP003012) hypothetical protein [Mesorhizobium loti]
    • gi|16124640|ref|NP_419204.1|_4:242 (NC_002696) aminomethyltransferase, putative [Caulobacter crescentus CB15]
    • gi|13421542|gb|AAK22372.1| (AE005711) aminomethyltransferase, putative [Caulobacter crescentus CB15]
    • gi|15234442|ref|NP_192950.1|_28:315 (NM_117283) putative protein [Arabidopsis thaliana]
    • gi|7485575|pir||T06620 hypothetical protein F16J13.200 - Arabidopsis thaliana
    • gi|4586118|emb|CAB40954.1| (AL049638) putative protein [Arabidopsis thaliana]
    • gi|7267914|emb|CAB78256.1| (AL161533) putative protein [Arabidopsis thaliana]
    • gi|15837670|ref|NP_298358.1|_27:280 (NC_002488) conserved hypothetical protein [Xylella fastidiosa 9a5c]
    • gi|11360745|pir||A82728 conserved hypothetical protein XF1068 [imported] - Xylella fastidiosa (strain 9a5c)
    • gi|9106015|gb|AAF83878.1|AE003943_9 (AE003943) conserved hypothetical protein [Xylella fastidiosa 9a5c]
    • gi|15606994|ref|NP_214376.1|_2:132 (NC_000918) hypothetical protein [Aquifex aeolicus]
    • gi|7514490|pir||C70472 conserved hypothetical protein aq_2004 - Aquifex aeolicus
    • gi|2984247|gb|AAC07775.1| (AE000767) hypothetical protein [Aquifex aeolicus] 
              10         20        30             40        50         
              |          |         |              |         |         
   1 AFTPFPPRQPTASARLP.LTLMTLDDWALATITG.....ADSEKYMQGQVTADVSQMAE.D....
   2 -FISFPPRHPSSSARLP.LTLIALDDWALSTITG.....VDSEKYIQGQVTADVSQMTE.Q....
   3 -FISFPPRHPSSSARLP.LTLIALDDWALSSITG.....VDSEKYIQGQVTADVSQMTE.Q....
   4 -FTPFPPRQPTASARLP.LTLMTLDDWALATITG.....ADSEKYMQGQVTADVSQMAE.D....
   5 -FTPFPPRQPTASARLP.LTLMTLDDWALATITG.....ADSEKYLQGQVTADVSQMTD.D....
   6 -------QPPVASSGLP.LTLISLDDWALVTLTG.....ADRVKYLQGQVTADIDALSA.D....
   7 ----------YPSINLP.LTLSLLEEWCLIYICG.....IDSKKHLQNQFTIDINCLKK.E....
   8 ----------YPSNELS.LTMILLEEWSLTYVEG.....IDSKKYLQGQLTIDINLLLK.T....
   9 PLHYGSQIDEHHAVRTD.AGMFDVSHMTIVDLRG.....SRTREFLRYLLANDVAKLTKsG....
  10 PVQFESIISEHEAVRNA.AGLFDVSHMGEIIVKG.....KDAFPFLQNLLTNDLSKLND.N....
  11 PLHYGSQIDEHHEVRTD.AGMFDVSHMTIVDLRG.....SRTREFLRYLLANDVAKLTKsG....
  12 PLHYGSQLDEHHAVRTD.AGMFDVSHMTIVDLHG.....SRTREFLRYLLANDVAKLTKtG....
  13 IWHFGDPLGEQRSAETD.AVLVDRSHRATLTLIG.....SDRQTWLHSISTQHVSALPD.G....
  14 IWHFGDPLGEQRSAETD.AVLVDRSHRATLTLIG.....SDRQTWLHSISTQHVSALPD.G....
  15 PVQFSSIKKEHEAVRTA.AGLFDVSHMGEVEVSG.....NDSLSFLQRLMTNDVSALTP.G....
  16 --NRFSVLNLSSHDPLPeLMLTHLTGWGAITLVG.....ADKKAYLQGQVTCNVVSLQE.Q....
  17 IWHYGDPLGEQRAGQAD.AVLVDRSHRAVLTLDG.....GDRQTWLHSISTQHVSDLPE.G....
  18 -LSFPPLDVQFTHAAQG.SVLCAPTNLARIAVEG.....ADAAEFLHNQLTNAVTGLGL.A....
  19 AWHYGSPLVEQRIFETG.TGLVDRSNRKVIKVEG.....PDAPTFLNNILSQKVDSVEN.G....
  20 AWHYGSPLVEQRIFETG.TGLVDRSNRKVIKVEG.....PDAPTFLNNILSQKVDSVEN.G....
  21 PVQFSSIKEEHEAVRTK.AGLFDVSHMGEVEVTG.....AQALNYLQRLVTNDVSKIKD.G....
  22 -----------------.---ISLTQYQLIEVQG.....ADAEKYLQGQLTSDVVRLAS.G....
  23 ----------------A.HVVCDLQQYTLLEIQG.....EDAEKYLQGQLTCDVNKLAV.G....
  24 -----------------.VAVYDRSNWGLIRVSD.....DDRLRFLHNQSTNDFQSLKP.G....
  25 AWHYGDPLVEQRAIHLNtPVLVDRSQRRVISVIG.....PDAPEFLNNLLSQKLDNVEP.G....
  26 --MRIPYARPVGPNQRN.FTLEPLGNRELIRVHG.....AEVVPFLQGLATNDVARIQS.Pggp.
  27 PLHYGSQVEEHHQVRRD.CGVFDVSHMTVVDVAG.....EQATAYLQHLLANDVARLGEtG....
  28 ----------------P.AFHTPLVHEGILAVRG.....PDAAKFLQGQLTCNLAYLND.E....
  29 ------WLHQTSPAHSP.FTIAPLPERKFVRVQG.....SDAVSFLQGLMTNDMRHLEH.S....
  30 ---GFGLLGSNPADGVA.WTCFRLDGRALVRVRG.....PDAAPFLLGLSTNELPLSGP.Ptg8s
  31 -FSSAGPVEEYWACRER.AAVIDLSPLRKFEVTG.....PDAEELLQYCLTRDVRKLST.G....
  32 --SFDNDDEALDAFDNG.VVVVDLSHFGRIRVSG.....DDRAHFLHNQTTANFESLYE.G....
  33 ---------------EQ.TWLYPLPEFSLIALQG.....EDRRRFLHNQTTNAVEARAV.G....
  34 PVQFSSIKEEHEAVRTA.AGLFDVSHMGEVEVKG.....VDSLAFLQRVVTNDVSTLKV.G....
  35 --HSSCSPGGDPTAGAA.WACFRLDGRTLLRVRG.....PDAAPFLLGLLTNELPLPSP.Aaa8a
  36 -----------------.-----LSNRDVIKIIG.....FDSVKFLQNLITNDICKSIV.Ns31d
  37 -FAKEGPLAEYWACRQD.AVIMDLSPLRKFEVTG.....PDSEALLQYTLTRDVKKLGV.G....
  38 -----------------.-----LINREIIKIIG.....LDSLIFLQKLITNDICK---.K....
  39 AAHYGDLFREQRALADG.TGFVDLSHRGVLAVTG.....DDRLSWLHLLLTQHVSDLPA.G....
  40 VQYPAGVLKEHLHTREQ.AGLFDVSHMGQIRLVG.....ADVALALESLVPVDILDLPV.G....
  41 YFNMFSCDYQTFLQMST.QRLIKLPHRVLLKLHG.....SDTNAFLQGLITNDVTKLQT.Q....
  42 -----------------.--KTLLPFFGVVRVSG.....EDRQTFLHGQLSNDINNLQT.G....
  43 -----------------.---VNLSYRALVHITG.....EEAEKFLQAVITTNLDQLGP.H....
  44 --ADFSIKESTIHTRKH.VSLFDVSHMLQTYITG.....KDRVAFIESLTTADVQGLQE.N....
  45 -----------------.--KTLLPFFGVVRVSG.....EDRQTFLHGQLSNDINHLQT.G....
  46 --VRSKFIKFSFQLFRN.YSVCLNSSKSLIRVEG.....VDAVKFLQGLTTNKITL---.D....
  47 -----------------.-----LADRRLIRVSG.....TGAEEFLNNLITADIENLPE.G....
  48 ----------------A.PFVCRLPSRRILRVRG.....TDAHDFLQGIFTNDLRELHP.A....
  49 ----------------P.HGFGSLHDMQYVRLSG.....PDAVAFAHAQFANDVQALAI.G....
  50 VQYPEGVLKEHLHTRAA.AGLFDVSHMGQIVVRPksgkiEDAALALEKLVPADVLGLAE.G....
  51 ----------------P.QGFGSLHDMQYVRLAG.....TDAVAFAHAQFANDVQALAI.G....
  52 ----PPTLCPVFSPYPD.LMWTRLPSSGL-RVTG.....ADRTDFVHGQMTGDLRGAPT.P....
  53 -----------------.---VCLDDRAIIRVSG.....KDAETLLQTLITTDIAALTA.D....
  54 -----------------.----LLKDRALISVSG.....PDAEHFLQNILTTDLDTLGA.G....
  55 -----------------.PCLARLASRAVIAVSG.....PDWRSFLQGLLTQDVETLAV.G....
  56 ---------------AG.PMASRLKSRSVVRFSG.....PDTVKFLQGLLTNDVRRFGE.Ss18t
  57 ---------------NG.QTLFPLPSYEMLRISG.....ADTLSFAHAQFSSDAQDLAI.G....
  58 -----------------.----------------.....--------------------.-....


           60        70                    80        90       100      
           |         |                     |         |         |      
   1 .QHLLAAHCDAKGKMWSNLRLF.....RDG..D.....GFAWIERRSVREPQLTELKKYAV.F..
   2 .QHLLAAHCDAKGKMWSTLRLF.....RER..D.....GFAWIERRSVLEAQLTELKKYAV.F..
   3 .QHLLAAHCDAKGKMWSTLRLF.....RER..D.....GFAWIERRSVREAQLTELKKYAV.F..
   4 .QHLLAAHCDAKGKMWSNLRLF.....RDG..D.....GFAWIERRSVREPQLTELKKYAV.F..
   5 .QHLLAAHCDAKGKMWSNLRLF.....RDG..D.....GFAWIERRSVREPQLAELKKYAV.F..
   6 .QHVLCAHCDAKGKMWSNLRLF.....YRG..E.....GLAFIERRSLLDNQLSELKKYAV.F..
   7 .EYKLCAHCNFNGKVWATMFIF.....HYK..K.....GFAYIIRKSIAKIQIKELKKYAI.F..
   8 .HHTLCAHCNFNGRVWSTMHLF.....HYE..K.....GYAYIQRKSVSQIQIKEICKYSI.F..
   9 .KALYSGMLNASGGVIDDLIVY.....YFTe.D.....FFRLVVNSATREKDLSWITQHAE.P..
  10 .QVLYTFMCNHNGGVIDDLLVY.....KYSn.N.....YYLLVVNAANIEKDYKWMLNNAG.I..
  11 .KALYSGMLNASGGVIDDLIVY.....YFTe.D.....FFRLVVNSATREKDLSWITQHAE.P..
  12 .KALYSGMLNASGGVIDDLIVY.....YFTe.D.....FFRLVVNSATREKDLSWITQHAE.P..
  13 .ASTQNLSLDSQGRVEDHWIQT.....ELG..G.....TTYLDTEPWRGEPLLEYLRKMVF.W..
  14 .ASTQNLSLDSQGRVEDHWIQT.....ELG..G.....TTYLDTEPWRGEPLLEYLRKMVF.W..
  15 .RAQYTAMCYPDGGTVDDLLIY.....QKGe.N.....RYLLVINASNIDKDLAWMKEHAA.-..
  16 .QVTFGAHCDAKGKVWSVFRLF.....HHH..D.....GYAMFQPQSAMEVELRELKKYAI.F..
  17 .ASTQNLSLDGQGRVEDHWIQT.....ELG..G.....TTYLDTEPWRGEPLLAYLRKMVF.W..
  18 .QARPAGYCSPKGRLLATLLLW.....RQA..D.....TIVLQTDKLVAPAITKRLSMFVL.R..
  19 .FTAGALDLDAQGRIQHTMQVT.....VVD..G.....VFYLDTSAAEFDTLIGFLTKMIF.W..
  20 .FTAGALDLDAQGRIQHTMQVT.....VVD..G.....VFYLDTSAAEFDTLIGFLTKMIF.W..
  21 .QAQYTAMCYENGGTVDDLLIY.....RRSe.D.....QYLLVINAANIDKDIAWMEKHAI.-..
  22 .ATTLTAHCDPKGKMNAIYRLF.....KVSs.E.....QFFLLVKKDILPSGLDALKKYAV.F..
  23 .ESTLAAHCDAKGKINSLFRLI.....RTAp.Q.....TFYLLVKKGLLPTALDQLKKYAV.F..
  24 .QGCETVMVTSTARTIDLVSSY.....VLN..D.....AVILLVSSSRREFLLQWLDRYIF.Fa.
  25 .YSAAALDLDIQGRILHYADVV.....RTD..E.....GFYLDTTDAEFESFLKFLTMMVF.W..
  26 .ASMYAHFLNKAGRLLYDTILY.....RTNnpE.....TILVECDREASSDFRRHLRTYRV.R..
  27 .KALYSAMLNEEGGVVDDLIVY.....LTE..H.....GYRVVVNASTRDKDIAWMQAQAA.G..
  28 .TSSLGGRCNIKGRLLSSFRIL.....PEG..D.....GLLLAMAGELLEAQLADLKKYAV.F..
  29 .STVYAMFLKANGRVFCDTIIY.....KRP..Gaepa.DYLLECDAAVAPRLEKHLKLYRL.R..
  30 aRAAYAHFLNVQGRTLYDVILY.....GLP..Ect6apSFLLECDSSVLGALQKHLSMYKI.R..
  31 .QVVYSAMCYEHGGMIDDGTLF.....RLGd.K.....NFRWIGGDDYSGIWLREQAEKKG.F..
  32 .QGCDTVFVTPTARTIDIAHAW.....IMK..N.....AILLTVSPTTCQSIIEMLNKYIF.Fa.
  33 .EWFETVFVNSTGRTLELATVY.....VRQ..D.....SLWLQVEAGQKDFLWQWMDRFIFpF..
  34 .GAQYTAMCYENGGTVDDLLIY.....KRGe.E.....DYLLVINASNIEKDYEWLASHVI.-..
  35 aRAGYAHFLNVQGRTLYDVILY.....GLQ..EhsevsGFLLECDSSVQGALQKHLALYRI.R..
  36 yNYCYTYLLNNQGRYLFDFFVY.....VHNp.E.....EIYLDIDKSNKAALIEYLNFYKF.R..
  37 .QVVYSAMCYEHGGMIDDGTLL.....RLGk.D.....NFRWVGGDDLSGEWLRETAKKLG.L..
  38 .RYCYTYLLNNQGRYLFDFFVY.....VHKk.E.....EIYIDIDKSNKTALIAHLNFYKL.R..
  39 .QATEALILSANGHIEHALYLV.....DDG..T.....TVWAHVEPGSQEALIAYLESMKF.F..
  40 .QQRYALFTDEQGGILDDLMVA.....NLG..D.....CLLLVVNAACKHQDLAHLRRHLE.-..
  41 .NGLAAFLLNTKGRIVEDVLLW.....RRGt.D.....DLFLECSKENKTILTKEILKYRL.R..
  42 .QACYATYNTPKGRVIANMIVV.....NRG..G.....DLLLIMAQDLLEATVKRLRMFVL.R..
  43 .ELKPGALLTPQGKILFDFLVS.....RIE..G.....GLRFDLPADVAGDFVKRITLYRL.R..
  44 .SGTLSVFTNEKGGIKDDLIIM.....KTDk.D.....FLFLVTNAGCIEKDLPYLQENAA.Awr
  45 .QACYATYNTPKGRVIANMIVV.....NRG..G.....DLLLIMAQDLLEATVKRLRMFVL.R..
  46 .NPVYTGFLNTQGRVLFDSFIYp10enERS..D.....ELYVEIDKVAESDFLKHLKKYNL.R..
  47 .ETRASALLTPQGKILFDFLIW.....RDG..R.....DYLVETGAAEQDALLRRLTMYKL.R..
  48 .GSMYGCFLYFTGRVLCDAHLY.....QCK..Qvh6qaSILVDVHERSATELLDHLTEMKM.R..
  49 .QWQWNAWLTAKGRVIAIFALL.....RDE..Da....QLLMLLPDGNAAEIAAQLGRFVF.R..
  50 .RQRYGLFTNAAGGILDDLMIV.....NRG..D.....HLFLVVNAACKDADLAHLKDGL-.G..
  51 .QWQWNAWLTAKGRVIAIFALL.....RED..Da....HLLMLLPDGNAAEIATQLSRFVF.R..
  52 .GLVPCAFLNVRGQIEQFARAY.....RRP..D.....DIYLHLDAGQAPLLAARLRRYII.F..
  53 .EVRPGALLTPQGKILFDFLIS.....RDG..E.....ALRLETTEDQAEALVKRLTMYKL.R..
  54 .ETKPGALLTPQGKILFDFLIS.....RAGe.N.....AFRLECRADISDDFVRRLMLYKL.R..
  55 .ELRFAGLLTPQGKLLYDLFVA.....GAE..D.....GALLDVAAAHRDAILTRLSMYRL.R..
  56 nPPMYAALLTPQGRFLYDFFLYs21sgRDG..-sv...ELFADVDVDVLDELLETLKKYRL.R..
  57 .KWHWSAWLTPKGRVTALFALY.....RPAe.N.....ELLLILPDGEAVMMATQLQRYIF.R..
  58 .---------------------.....---..-.....-----------------------.-..


             110       120       130                 140            150
              |         |         |                   |              |
   1 ...SKVTIAPDDERVLLGVAGFQARAALAN.....LFSELP.....SKEKQVV.....KEGATTL
   2 ...SKVVIAPDDERVLLGVAGFQARAALAN.....VFSELP.....NSENQVV.....RDGASTL
   3 ...SKVVIAPDDERVLLGVAGFQARAALAN.....VFSELP.....NSENQVV.....RDGASTL
   4 ...SKVTIAPDDERVLLGVAGFQARAALAN.....LFSELP.....SKEKQVV.....KEGATTL
   5 ...SKVTIAPDDERVLLGVAGFQARAALAN.....IFSELP.....SKEKQVV.....KEGATTL
   6 ...SKVVIEPQPDAVLIGVAGSQAKTALAE.....IFTELP.....SAEHPVT.....QMGNSTL
   7 ...SKVEIRELDDIYLFGLSGFNAKFFLSK.....NFVDIP.....NKNCSLI.....SNQDRTI
   8 ...SKIKIRELNSICLIGFAGCNVRSFLSS.....LFVKIP.....NQSCPVI.....HEDNKTI
   9 ...FGIEITVRDDLSMIAVQGPNAQAKAAT.....LFNDAQrq7gmKPFFGVQ.....AGDLFIA
  10 ...YKVEIENVSDKIAELAIQGPKAEEILQ.....KLTDED.....LSQIKFFyf9iaGVECLVS
  11 ...FGIEITVRDDLSMIAVQGPNAQAKAAT.....LFNDAQrq7gmKPFFGVQ.....AGDLFIA
  12 ...YAIDITVRDDLSLIAVQGPNAQEKAAT.....LFTDQQrh7gmKPFFGVQ.....AGDLFIA
  13 ...SEVTPGSADM-AMLSLLGPRLTEQAVH.....NALYLDalpd.ESTAVPL.....TAGSFVR
  14 ...SEVTPGSADM-AMLSLLGPRLTEQAVH.....NALYLDalpd.ESTAVPL.....TAGSFVR
  15 ...GDVQIDNQSDQIALLAVQGPKAEAILK.....NLTDAD.....VSALKPFaf9isGRKALIS
  16 ...SKVTIAESSD-IALGVMGSQA-DAWID.....TVSETT.....GDVRRIA.....GGTAV--
  17 ...SMVTPRAADM-AVLSLLGPRLAEERVL.....DALGLD.....VLPAEWLav6agGGIVRRM
  18 ...AKAKLRPMDEFIAITVAGPDAADALRA.....AGAVLP.....ESDAPYAv10gqQVGAVVR
  19 ...SEVTVQEADLAIITLL-----------.....------.....-GQEIAL.....PDAVFAR
  20 ...SEVTVQEADLAIITLL-----------.....------.....-GQEIAL.....PDAVFAR
  21 ...DGVSITNVSNQTAQLALQGPVAENVLQ.....TLTEEP.....LADIKFFrf9iaGVNVLLS
  22 ...SKVSFDLRDWQI-IGVIGEKCGKITPN.....FSLEID.....EKRSILL.....NE-----
  23 ...SKVTFTPCDWQI-IGLAGEKIINACDE.....I-----.....-------.....--DAQIR
  24 ...DKVQLTDITDETATLSIIGPGSDAVVEklgagEIIGQP.....HGNHITI.....DGGVVAA
  25 ...SKVEVAEADLAIITLLGQVPT------.....------.....LPDSVAA.....SAAFVRE
  26 ...RRIEVDSVDDEY-TPWVMFNLKDASEA.....VPNPHP.....-------.....--DLFVS
  27 ...FKVDLQERGDLAMLAIQGPNARVHSSE.....LVSPARaa7elKPFQGRA.....EGDWFIA
  28 ...SKASLADESA-AWLRIGLRDASEALRA.....LGIDTP.....AESGRIA.....RHGD--L
  29 ...KKVQVEQDAT--YRVWAAFKEAVQEEE.....EMPAAS.....DLACP--.....EGRLHVF
  30 ...RKVTVEPSPE--LHVWAVLPCVPQTSE.....TA----.....-PLEERV.....EGTTMLI
  31 ...RAWVRSSTDQMHNIAVQGPKSRDILKE.....IVWTAP.....RQPTIGEl15feGAPIVVS
  32 ...DKVEIKDITKQTCLFALAGPKSNQLHY.....SYATVK.....NMKQIMSk21fdGMPITVG
  33 ...DKVELRDLSA-HYRAVVLLGEKVEEHN.....LGWQLP.....TGNQWLAqsvq.GVELLIS
  34 ...GDATVVNVSSEVAQLAIQGPKAEGILQ.....KVVSED.....LKEIKFFkf9vdGIPALVS
  35 ...RKVTVEPHPE--LRVWAVLPSSPEACG.....AA----.....-SLQERA.....GAAAILI
  36 ...SKIQVIDCSNEY---KVIYSLQKLDIE.....SLITVR.....DPRYAKL.....GFRSINK
  37 ...NVLVRSSTDQMHNVAVQGPKSRDILRE.....VVWTSP.....LQPSIDEl15gnGIPVVVS
  38 ...SKIQIIDCSEEY---KVIYSHKKLDID.....MLITVR.....DPRYTKL.....GFRSINK
  39 ...YRVEVADRTADTALVHLPAGSIA----.....------.....-------.....--QAPAS
  40 ...GRCSVEPLFEERALLALQGPAAVRVLE.....RLAPQV.....AQMTFMQfa7llGQDCYVS
  41 ...KQVEITESSDQIFFTEDVSDKQ-----.....------.....-------.....-----AH
  42 ...AKAVFEILED----YAVGAELEASAEP.....LAAQEP.....-NLAFAA.....QQDSDGI
  43 ...AKAEIVQVPESLVSVCWQGDS------.....------.....-----PA.....SDNDSIK
  44 skgKDVKIETLDNRG-LVAVQGPEMAKVLQ.....EGTDID.....LSKLTFMkt9fgIDGCRVT
  45 ...AKAVFEILED----YAVGAELEASAEP.....LAAQEP.....-SLAFTA.....ECGSDGI
  46 ...SRCSIAKIPSEELSIKVIWDV------.....------.....-KEESRL.....KDTVAYA
  47 ...APVELKAETVEGIGVFWGNSVTE----.....------.....-------.....----AGV
  48 ...KKVHIDDVGKEL---VVLAALEETSAD.....AQRSRD.....SASGCDA.....RESSVTS
  49 ...RKLRITEIAL-TAQGAFAAPARAQAAH.....ADVAAD.....-------.....----AIE
  50 ...SVCDVTMLTDRALIALQGPRAGAVLCE.....LWADVS.....SMRFMDVte6lhDVSCIIS
  51 ...RKLKIGIATLFAYGGFAAPEHAHAARA.....EI----.....-------.....GTQRIEL
  52 ...DQVELEDVSE----VLRTVHVWDQAVP.....GWDDAG.....AGAQQWT.....LGGSLVL
  53 ...SAVDLSLNSPAPVTVVFGEDA------.....------.....-------.....--PAESY
  54 ...AKVEIAKSEQSLVAVAWG---------.....------.....-KESIAS.....ENDSTAF
  55 ...AKVELVASDRPVIAVFGGATS------.....------.....-------.....--GEGLY
  56 ...SKVDIENVAEEF---------------.....------.....-SCWQRY.....GRNLTGS
  57 ...RKVQIAVERDLITTGTYDTPVHAT---.....------.....-GTQAAQ.....LDGITEL
  58 ...---------------------------.....------.....-------.....-------


                 160       170       180                 190           
                  |         |         |                   |           
   1 ..LWFEHP..AERFLIVTDEATANMLTDKLRGEA.....E.....LNNSQQWLALNIE....AGF
   2 ..LWFEHP..AERFLLVTDVATANMLTEKLHGEA.....E.....LNNSQQWLALDIE....AGI
   3 ..LWFEHP..AERFLLVTDVATANMLTEKLHGEA.....E.....LNNSQQWLALDIE....AGI
   4 ..LWFEHP..AERFLIVTDEATANMLTDKLRGEA.....E.....LNNSQQWLALNIE....AGF
   5 ..LWFEHP..AERFLIVTDEATANMLTDKLRGEA.....E.....LNNSQQWLALNIE....AGF
   6 ..LHFSLP..AERFLLVTDTEQAQQLVEKLAGRA.....Q.....FNDSKQWLALDIE....AGF
   7 ..LWFSEP..CERFLLVLSLKDLLLLKRKENEIT.....L.....LNNSKQWLLFDIE....AGF
   8 ..LWYEKP..SERFLLVLPFLDFLTLKRKINQNI.....F.....LNNSKQWLLLDIE....AGL
   9 ..TTGYTG..EAGYEIALPNEKAADFWRALVEAG.....Vk....PCGLGARDTLRLE....AGM
  10 ..RTGYTG..EDGFEIYMPNEHAVTLWEKILEAG.....KdyglkPAGLGARDTLRFE....AGL
  11 ..TTGYTG..EAGYEIALPNEKAADFWRALVEGG.....Vk....PCGLGARDTLRLE....AGM
  12 ..TTGYTG..EAGYEIAMPNEKAADFWRALVEAG.....Vk....PCGLGARDTLRLE....AGM
  13 ..RIPGAPagQIELDLLVPRRESADWQSRLAGVG.....Vr....SAGMWAYEAHRVA....ALR
  14 ..RIPGAPagQIELDLLVPRRESADWQSRLAGVG.....Vr....SAGMWAYEAHRVA....ALR
  15 ..RTGYTG..EDGYEIYCRSDDAMHIWKKIIDAG.....DaygliPCGLGARDTLRFE....ANV
  16 ..---RMS..PQRWLLLVNAEQAEQYVNAWQGLH.....V.....EQSL--WTRMDIE....EAV
  17 ..PDGLAG..QIELDVVVKRGDRADWQRRLTQAG.....Vr....PAGIWAYEAHRVAhrvpARR
  18 ..LPDAGN..RARYQWLVHAEHFQHAWKTLSSRL.....A.....LIGTEVWDWLGLQ....AGV
  19 ..RVDWNG..PSRIDVAIRRENLEEGVDKLLEAG.....Ak....LTGLMAYTAERVK....ALE
  20 ..RVDWNG..PSRIDVAIRRENLEEGVDKLLEAG.....Ak....LTGLMAYTAERVK....ALE
  21 ..RTGYTG..EDGFELYCLAEDAPVLWKKLIEAG.....KehgvvPCGLGARDTLRFE....AKL
  22 ..------..------------------TELPVN.....F.....NGDEKIWEVADIQ....AGL
  23 ..VTLSSQ..QPRVILIHPTA---------LDLQ.....A.....NASHVVWDLLDIQ....DGI
  24 ..VGSGLA..SPGYTLILPVSQKQQVWQQILDSG.....Av....ELSDRAWDTLRIL....QGR
  25 ..VPNWTQ..TPRTDIAVPREQLKDVAKELISAG.....Fk....PAGLMAYTAERVR....NLE
  26 ..PDPRLH..VLGTRILAPTD---MDWSKLSKCF.....Adf7taASSDNSYQLLRYK....QGV
  27 ..RTGYTG..EDGLEIMLPAAEAPGFLNELVGAG.....Is....PAGLGARDTLRLE....AGL
  28 ..LAVALG..DGRVELWVPAQRAEAVLATLREHS.....R.....EAPLDDWLLGQVR....AGI
  29 ..KDPRLP..RLGYRVLTDEQEPNECKTRLKRIF.....PeaetvADSALPYTAFRYS....LGV
  30 ..RDPRTA..RMGWRLLTQDDGPA-----LVPRG.....Q.....LGDLQDYHKYRYQ....QGI
  31 ..RTGYTG..ELGYEIFCHPKDALTVFDAVWRAG.....EphglrPMGLEALDMVRIE....AGL
  32 ..VGSLIS..DEGFTMLMSPGGAVSVWKTLLAEG.....Ai....PMGSVAWEKLRIT....QGR
  33 ..AQTGLD..LPGYTVIFPADQQE-LVNQLWGHL.....P.....LINPDQWESLRIY....QGR
  34 ..RTGYTG..EDGFEIYCKSEDAAKLWEKLLEVG.....AeeglkACGLGARDTLRFE....ATL
  35 ..RDPRTA..RMGWRLLTQDEGPA-----LVPGG.....R.....LGDLWDYHQHRYL....QGV
  36 ..LDV-IP..LCGIQTIIKKDWTPWSSHRVTEGE.....Ppp8pcENGNPIYLEDKYN....FAI
  37 ..RTGYTG..ELGYEIWCHPRDAEKVFDAIWEAG.....QphglkPMGLQALDMVRIE....AGL
  38 ..LDITCS..SDNMANMESISSITSYCQSMNPI-.....-.....------YLEDKYN....FAI
  39 ..AVVRET..PYGRDLFLPREELEAF---AAQAG.....P.....AAGILAHEALRVE....QHR
  40 ..RSGYTG..EDGYEISVPAAHAEALARRLLAEP.....Eva...PIGLGARDSLRLE....AGL
  41 ..RDPRFS..GFGARVFGNPSSSE----------.....V.....SENREKYENLRRS....AGI
  42 ..CSIALP..HGGILRIAPKN--------TLPPY.....D.....AAAENAWRLHEIR....SGY
  43 ..RDSRFPa.QLNVLRLYHQASAN----------.....-.....-AGLDAWVQLRAE....YGI
  44 ..RCGYTG..EDGVEISVDPTKAEQLVERLLASQ.....Agsvk.LAGLGARDALRLE....AGL
  45 ..CSVVLP..HRGILHIAPKN--------ALPPY.....D.....AAAENAWRLHEIR....SGY
  46 ..KDPRFS..KQRLLRMIVPTSTC-------TSS.....S.....SGSLDDYKVFRYR....NGI
  47 ..RDGRFA..KAGVDL-----------RRVPGAS.....A.....SGEAAAYEALRVE....HGI
  48 ..LSPETL..EERHTECFLDPRNDALFPRPPPPSs26apP.....LSSPDSYTTLLYS....RGI
  49 ..LDMGSP..ALPRTLVLRASDTL-----AAPID.....L.....PNMDAAWRRADLQ....LGL
  50 ..RSGYTG..EDGFEISIPAEAAVDVTQRLLEHP.....Dvl...PIGLGARDSLRLE....AGL
  51 ..DLGSTA..LPRTLLLYSADALA------TPIE.....L.....PSADAQWRTTDLQ....LGL
  52 ggRVNRSG..QPGVDLHYLARDEEAVLAALGGEE.....R.....PLSE--LDALRVA....AGI
  53 ..RDHRFE..KAGVSVFRLYRDVP---------A.....A.....EAGIADLDRLRIA....AGI
  54 ..ADKRFA..KE------------SVTRTYAGIA.....D.....AGDIAAWQAFRIA....HGM
  55 ..ADPRLP..ALGARAYDDRATNA----------.....-.....--DEDVYEAHRLA....LGV
  56 ..SSVGWG..G-GVDRAAP----------LVEAD.....K.....ETDESNYLLWRLE....HGV
  57 ..DVSGIT..LPRRLLLVPTA--------AMPPR.....V.....PAFEAQWRAADLR....LGL
  58 ..------..--GFDLFGKIEDIL----KELPQD.....K.....EASVEDFEEERIK....NCV


      200        210                 220        230        240       25
       |          |                   |          |          |         
   1 PVIDAAN.SGQFIPQATNLQA.....L.....GGISFKKG.CYTGQE.MVARAKFRGANKRALWL
   2 PVIDAAN.SGQFIPQATNLQA.....L.....GGISFKKG.CYTGQE.MVARAKFRGANKRALWL
   3 PVIDAAN.SGQFIPQATNLQA.....L.....GGISFKKG.CYTGQE.MVARAKFRGANKRALWL
   4 PVIDAAN.SGQFIPQATNLQA.....L.....GGISFKKG.CYTGQE.MVARAKFRGANKRALWL
   5 PVIDAAN.SGQFIPQATNLQA.....L.....GGISFKKG.CYTGQE.MVARAKFRGANKRALWL
   6 PIIDAAN.SAQFIPQATNIQA.....L.....NGISFTKG.CYTGQE.MVARAKYRGANKRALYW
   7 PIIDKQT.SQKFLPQSINLIL.....L.....QAVSFDKG.CYYGQE.TIARVFYKNLNKYSLYL
   8 PVIDKIC.SNKFTPQAINLHN.....L.....KAISFKKG.CYYGQE.TIARIFFKKTNKYFLCF
   9 NLYGQEM.DETISPLAANMGW.....T.....IAWEPADR.DFIGRE.ALEVQREHGTEK--LVG
  10 PLYGNEL.GEDITPLEAGLGF.....-.....-FVKFDKG.NFIGKD.ALLKQKEQGL-KRKLVG
  11 NLYGQEM.DETISPLAANMGW.....T.....IAWEPADR.DFIGRE.ALEVQREHGTEK--LVG
  12 NLYGQEM.DEGISPLAANMGW.....T.....IAWEPADR.DFIGRE.ALEMQREKGHEQ--LVG
  13 PRLGVDT.DQRTIPHEVGWIG.....Gpge..GAVHLDKG.CYRGQE.TVARVQNLGKPPRMLVL
  14 PRLGVDT.DQRTIPHEVGWIG.....Gpge..GAVHLDKG.CYRGQE.TVARVQNLGKPPRMLVL
  15 PLYGQEL.TRDITPIEAGIGF.....-.....-AVKHKKEsDFFGKS.VLSEQKENGA-KRKLVG
  16 PVVTQTA.QNEHIPQALNVQA.....V.....DGISFTKG.CYTGQE.TVARAKYRGINKRAMYI
  17 PRLGVDT.DERTIPHEVGWIG.....Gpga..GAVHLNKG.CYRGQE.TVARVHNLGRPPRMLVL
  18 PSITLST.QEQFVPQMVNLEL.....I.....GGVDFRKG.CYPGQE.VVARSQYRGTLKRRMQR
  19 PAAGVDL.DDKTIPHEIPHWIgrgehL.....GAVHLTKG.CYRGQE.TVARVDNLGRSPRVLVL
  20 PAAGVDL.DDKTIPHEIPHWIgrgehL.....GAVHLTKG.CYRGQE.TVARVDNLGRSPRVLVL
  21 PLYGQEL.TKDISPIEAGIGF.....-.....-AVKVDKE.DFIGKE.ILKKQKEQGAPRK-LVG
  22 PNLSPQT.QNEFIPQALNLQA.....Ie....QAISFTKG.CYIGQE.TVARAKYRGANKRAMFI
  23 PLLSPET.QAEFIPQALNLQC.....Le....HAISFQKG.CYIGQE.IVARAKYRGANKRAMFT
  24 PAPDAEL.TDDYNPLEVGLWQ.....-.....-TISFSKG.CYIGQE.TIARLNTYKGVKQHLWG
  25 PEKAADL.DDKSIAHEIAHWI.....GrgeipGAVHLEKG.CYRGQE.TIARVENLGRSPRLLTL
  26 GEGCSELtPGKCFPLEANADY.....L.....HGVSFHKG.CYVGQE.LTARVHHSGVIRKRYMP
  27 NLYGQDM.DESVSPLAANMGW.....T.....VAWEPVAR.DFVGRR.ALEAQKAAGDQPK-LVG
  28 GQVFGAT.RELFIPQMINLQA.....V.....GGVSFKKG.CYTGQE.IVARMQYLGRLKRRLYR
  29 GEGETNLpDGKCFPLECNCDL.....L.....HGVSFHKG.CYIGQE.LTARTYHTGVIRKRLMP
  30 PEGVCDLpPGMALPLESNLVF.....M.....NGVSFTKG.CYIGQE.LTARTHHTGVIRKRLFP
  31 IFAHYDF.DDQTDPFEAGIGF.....T.....VPLKSKHD.DFIGRE.ALIRRKENP--RHLMVG
  32 PAPEREL.SKEFNVLEAGLWN.....-.....-SISLNKG.CYKGQE.TIARLMTYDGIKQRLCG
  33 PQAGKEL.TEDYNPLEAGLWR.....-.....-AISFTKG.CYIGQE.TIARLNTYQGVKQRLWR
  34 PLYGQEL.SKDITPIEAGIGF.....-.....-AVKTNKEaDFFGKA.TLKEQKENGAPRK-LVG
  35 PEGVRDLpPGVALPLESNLAF.....M.....NGVSFTKG.CYIGQE.LTARTHHMGVIRKRLFP
  36 IDGVEDLiTDKSIPNMYGAEE.....L.....NAISFDKG.CYVGQE.VISRAKYQGVIRRKIYK
  37 IFAGYEF.SDQTDPFEAGIGF.....T.....VPLKSKTD.DFIGRE.ALIRRKEHPQTK--LVG
  38 IDGIEDLiTDKSIPNMYGAEE.....L.....NAISFEKG.CYVGQE.IISRTKYQGVIRRKVYR
  39 PRLGFET.DHRTIPHELGWIG.....T.....-AVHLQKG.CYRGQE.TVARVQNLGKPPRRLVF
  40 CLYGHDM.DSATTPVEASLGW.....AiskarRADGVRAG.GFPGAE.RIFAQQAQGVASKRVGF
  41 AEGSQELa--ELLPFQANGDL.....L.....NMVSLDKG.CYVGQE.LTARTAHTGVIRRRILP
  42 PWICAAT.KETAVAQMLNQHI.....I.....GGVHFKKG.CYPGQE.IIARAQYRGQVKRGLAV
  43 AEGEADFaYGDVFPHDVNFDQ.....T.....GGVSFPKG.CFIGQE.VVSRMQHRGTTRRRVLI
  44 CLYGSDI.EENTTPIEAGLAF.....V.....VAKRRRETlDFPGAEhIVKQLKEKSWPKRRVGL
  45 PWICAAT.KETAVAQMLNQHI.....I.....GGVHFKKG.CYPGQE.IIARAQYRGQVKRGLAV
  46 PEGPQEIiPSISFPLESNMDW.....M.....KGIDFHKG.CYLGQE.LTVRTYYTGVTRKRIFP
  47 AESGRDYaLQDAFPHDVLMDV.....N.....DGVSFKKG.CFVGQE.VVSRMKHRGTARRRVVT
  48 GEGPDVFkCNKSLPFEGNLDF.....L.....KGVSFHKG.CYVGQE.LTHRTHVMLVTRKRTVP
  49 VRLPDTQ.REQWTPQQLALDQ.....L.....HAFSVKKG.CYPGQE.IVARTHFLGKAKRAVHL
  50 CLYGNDI.DTNTSPIEAGLEW.....AiqksrRAGGERAG.GFPGAG.RILAELTDGVSRRR-VG
  51 ARLVEGQ.REQWTPQQLALDR.....L.....QAYSVKKG.CYPGQE.IVARTHFLGKAKRALQL
  52 PDIQRDG.LTGTLPQEVGLDVsgp..L.....PAISYRKG.CYVGQE.IMARIEARGQTRFHLAR
  53 AVAGRDYdLQDAFPHDVLMDL.....N.....GGLSFRKG.CYVGQE.VVSRMQHRGTARRRLVI
  54 AESGADYaLGDAFPHDVLLDE.....T.....GGVGFKKG.CYVGQE.VVSRMQHRGTARRRVLI
  55 PGPTDWG.SEATYPIEANFDL.....L.....AGIDFKKG.CFVGQE.TTSRMKRRGTIKNRMLP
  56 AEGSAEIpKGEAIPLEYNFVG.....L.....NAISFDKG.CYVGQE.LIARTHHRGVIRKRLIP
  57 PRLDASQ.RDQWTPQQIGLDG.....L.....NAYSIRKG.CYPGQE.IVARTHFLGKAKRRAQL
  58 PRIHKEL.REGFSPLEAGVLP.....Y.....-AISLNKG.CYVGQE.AIARVYFRGRTPRVLTK


      0               260         270       280            290         
     |                 |           |         |              |         
   1 LAGSAS.....RL...PEAGEDLELK..MGENWRRTGTVLAAVKLEDG....QV.VVQVV.....
   2 LAGKAS.....RV...PEAGEDLELQ..MGENWRRTGAILAATQLDDG....QL.LVQAV.....
   3 LAGKAS.....RV...PEAGEDLELQ..MGENWRRTGAILAATQLDDG....QL.LVQAV.....
   4 LAGSAS.....RL...PEAGEDLELK..MGENWRRTGTVLAAVKLEDG....QV.VVQVV.....
   5 LTGSAS.....RL...PEAGEDLELK..MGENWRRTGTVLAAVKLEDG....QV.VVQVV.....
   6 LAGNAS.....RV...PAAGEDLEWQ..LGENWRRTGTVLSAIQLNDG....TV.WVQAV.....
   7 LSSKGN.....IN...PKIGSIIEMK..KEEKWYRIGFLLAIVHVEFN....RT.VIQAV.....
   8 LVSTGS.....IF...PKIGSFIETK..VDSEWFKVGVLLSIVHVKCE....EI.YIQVV.....
   9 LVMTEK.....GV...LRNELPVRFT..DAQGNQHEGIITSGTFSPTL....GYsIALAR.....
  10 FEMIGN.....GI...PRHGYEVQA-..---DNQKIGYVTTGYFSPTL....K-.-----.....
  11 LVMTEK.....GV...LRNELPVRFT..DAQGNQHEGIITSGTFSPTL....GYsIALAR.....
  12 LVMTEK.....GV...LRNELPVRFT..DAQGNQQEGIITSGTFSPTL....GYsIALAR.....
  13 LHLDGS.....VE...RTSTGDAVL-..--ANSGAVGRLGTVVEHVDL....GP.VALAL.....
  14 LHLDGS.....VE...RTSTGDAVL-..--ANSGAVGRLGTVVEHVDL....GP.VALAL.....
  15 LEMIEK.....GI...PRHGYEVFQ-..---NGKSVGKVTTGTQSPTL....G-.-----.....
  16 VKGNLS.....AP...LSQDEPVVLEraVGENWRSAGALLTHYRFTDS....IA.IGLIV.....
  17 LHLDES.....VQ...RPSTGDAVL-..--AGGRTVGRLGTVVEHVEL....GP.VALAL.....
  18 AHVDA-.....-P...TSAGAEVFSA..A-DPNQPCGMVVNAAMAPDG....GT.DLLVE.....
  19 LHLDGS.....AP...LDPVTGAEI-..-KAGARTVGRLGTVVHDADY....GP.IALGL.....
  20 LHLDGS.....AP...LDPVTGAEI-..-KAGARTVGRLGTVVHDADY....GP.IALGL.....
  21 LEMVDK.....GI...PRTGYEVYV-..---DNQKIGFVTTGTQSPTL....K-.-----.....
  22 FKVQTQ.....QE...AEIGSEIEMQ..LEANWRKTGTITSAVNLDGV....-L.WLQVV.....
  23 FVAQSQ.....EM...PNIKSEVEMQ..LENHWRKTGNIISAVNFEGT....-L.WLQVV.....
  24 IRLNA-.....-P...AEIGDSINI-..---GDEKVGKLTSYTETPDG....YF.GLAYI.....
  25 LHLDGS.....VPel.PATGTDITS-..---GGRRVGRVGSIIDDFEL....GP.IALGL.....
  26 IRLTAP.....ID...VGSSQDVTS-..--LAGAKLGRVFGFAHKHGI....AL.LRIEK.....
  27 LVLEER.....GV...LRAHQVVRV-..---AGIGEGEITSGSFSPTL....NKsIALAR.....
  28 LALDAD.....EV...PAPGTGLFS-..-PVHSTSVGEVVLAARTPEN....SV.ELLAV.....
  29 LELDAPhrladCD...PEALRDAEI-..KNEEGGAVGKLRGLAGNRAL....GL.LRIEKvl7kp
  30 VKLEGP.....LPasgVSPGAIVTV-..-TATGQAAGKFRAGQGHVGL....AL.LRSET.....
  31 LDIQAN.....EA...VGHGDCVHV-..---GRAQIGVITSATRSPVL....G-.-----.....
  32 LNLSA-.....-P...SEPGSTITV-..---DGKKVGKLTSYTGGKNG....--.-----.....
  33 ITLDR-.....-Q...AEAGTVITL-..---EGQKVGILTSVKGLTGL....GY.LKTKL.....
  34 IEVIER.....GI...PRTHYPVFI-..---GEEKIGEVTSGTQSPTLkksiGL.ALIDV.....
  35 VRFLDP.....LP...TSGITPGATV..LTASGQTVGKFRAGQGNVGL....AL.LWSEK.....
  36 ITADED.....LS...SLVKDEEIL-..--ADNNTIGVICSSYHNKAI....AL.IREEK.....
  37 LDIDSN.....VA...VGHGDCVHV-..---GRAQIGVVTSGMRSPVL....G-.-----.....
  38 ITANED.....LL...SLVQDDVIL-..--ADNEKIGVICSSYQNKGI....AL.IMEKK.....
  39 LHLDGSev...HL...PPNGAEIRLAd.DGPDGRKIGFVTTSVRHHEL....GP.VALAL.....
  40 LPQGR-.....MP...VREGAEIVD-..--AQGRAIGKVSSGGFGPSL....NApLAMGY.....
  41 FECEG-.....-Q...VKIGAEVLD-..--EKKNKVGKIISSDTTRCL....GI.LQLSS.....
  42 LSGNS-.....-A...AEAGSVLAA-..---DGEEAGIVLDSVQDSEN....-F.TALAV.....
  43 ARSDVP.....-L...PPMGTPITV-..---EGREIGAMGSSASQIGL....AL.VRIDR.....
  44 LAPAGR.....CP...RSHLPLIDP-..--LDKCSIGFVTSGCPSPTL....GKnIAIAY.....
  45 LSGNS-.....-A...VEAGTLLTA-..---DGEEAGIVLDSVQDSEN....-F.TAL--.....
  46 FIIPNYe15lsIV...AKQGEPV---..---SRRSPGKIIAILGKVGL....AL.VRLQY.....
  47 VSADG-.....TL...PASGTEITA-..---NGKPVGALGTVYGNRAL....AI.VRTDR.....
  48 LHFGPAn19ktWP...VEVGEPLYS-..--AAREKIGEVTGVCGQVGI....GL.FRLRY.....
  49 LETDA-.....-A...VAPGDAVRL-..---DGAEVGSVVSCAENVAL....AV.LPLE-.....
  50 LRPEGR.....AP...VRGNANLFA-..DEEGRTAAGTVTSGGFGPS-....--.-----.....
  51 LETDA-.....-A...VDAGDAVAL-..---DGSAIGTVVSVAGNLAL....AV.LPLE-.....
  52 VAGEG-.....--...LPSHAEIRQ-..---GDKVVG-----QSGLST....GP.LALAR.....
  53 VAGAA-.....TL...PPSGTNISV-..---DGRPIGSLGTVLDRDGL....AI.VRIDK.....
  54 VQAGL-.....AL...PAPGTELTV-..---EGRPVGTLGSSAGDIGL....AI.ARIDR.....
  55 ITFDGP.....-P...PPFGAEVLA-..---GELRAGEVLSGRDGQAM....AL.LRLDR.....
  56 LRFIDSngke.LN...QKIAAGAEVV..ESGTGKKMGTVSTALGSRGM....GV.MR---.....
  57 LAINT-.....-H...VQPGETVKS-..---AEGDIGQVASVAEGLAL....AV.LPI--.....
  58 FEVIE-.....-Q...VKEEEKILE-..---GNKAIGLITSVSPSGKM....AL.GYILR.....


            300         310         320     
             |           |           |     
   1 MNN...DMEPDSI..FRVRDDA.NT.LHIEPLPYSLEE
   2 MNN...DLEAESV..FRVRDDA.NT.LHIVPLPYSLEE
   3 MNN...DLEAESV..FRVRDDA.NT.LHIVPLPYSLEE
   4 MNN...DMEPDSI..FRVRDDA.NT.LHIEPLPYSLEE
   5 MNN...DMEPDSI..FRVRDDA.NT.LCIEPLPYSLEE
   6 LNN...DLAADSV..LRVRDDAlGT.LAIQPLPYSLAE
   7 LNK...SINIQNI..FRIYEFK.NI.FLI---------
   8 LRK...SVNINNL..FRIHGFE.NI.FLI---------
   9 VPE...GIGETAI..VQIRNRE.--.------------
  10 ---...-------..-------.--.------------
  11 VPK...GIGETAI..VQIRNRE.--.------------
  12 VPA...GIGETAI..VQIRNRE.--.------------
  13 LKR...GLPTDTE..L------.--.------------
  14 LKR...GLPTDTE..L------.--.------------
  15 ---...-------..-------.--.------------
  16 LPN...DLEHDVK..LRLAAQP.DTrWHIQPLPYSLSD
  17 LKR...GLPGDTA..LVTG---.--.------------
  18 LKL...DALDTVI..HLATADG.PV.LTLQRLPYAI--
  19 VKR...SALDK--..-------.--.------------
  20 VKR...SALDK--..-------.--.------------
  21 ---...-------..-------.--.------------
  22 MNN...DIDSEQQ..FRLLNSE.IL.LERVQLPYSITE
  23 LNN...QLEEDVQ..FRLSE-H.TA.LTRFPLPYTL--
  24 RSK...AGGVGLK..VQVGNSE.GE.VVA---------
  25 IKR...SA-----..-------.--.------------
  26 VLN...GRPELMIdgERCYVER.PE.WWPEDLP-----
  27 VPA...ATGDRAE..V------.--.------------
  28 LQD...DAVADGR..ISLGSAE.GApLVLLNLPYTLD-
  29 LTI...NVAGESV..VRCRTSK.PA.WWPK--------
  30 IKG...PLHI---..-------.--.------------
  31 ---...-------..-------.--.------------
  32 ---...-------..-------.--.------------
  33 VDQ...GM-----..-------.--.------------
  34 KYA...AVDTEVE..IEIRN--.--.------------
  35 IKG...PLH----..-------.--.------------
  36 YLA...DKEADV-..-------.--.------------
  37 ---...-------..-------.--.------------
  38 ---...-------..-------.--.------------
  39 VKR...NVPVDAR..LM-----.--.------------
  40 VPSelaGLGSEVT..AMVRGKP.VT.LVVSKMPF----
  41 FKS...QKLTADG..VSLTAKQ.PE.WMPD--------
  42 IKF...-------..-------.--.------------
  43 VKD...AMDTGNS..ILAGDAA.IT.LS----------
  44 VDK...-------..-------.--.------------
  45 ---...-------..-------.--.------------
  46 LKS...DLACNGI..PIQLNTS.IW.------------
  47 VAD...ALAAGTP..LLADNV-.--.------------
  48 VDK...-------..-------.--.------------
  49 ---...-------..-------.--.------------
  50 ---...-------..-------.--.------------
  51 ---...-------..-------.--.------------
  52 LRR...ELEDGAA..VEVGG--.--.------------
  53 AGE...AIAKSEA..ILAGDVR.LT.L-----------
  54 VKV...ALDAGQP..ILAGDVP.VR.L-----------
  55 I--...-------..-------.--.------------
  56 ---...-------..-------.--.------------
  57 ---...-------..-------.--.------------
  58 AKF...EKG----..-------.--.------------