(c) 1992-2000 Regents of the University of California, Santa Cruz
Sequence Alignment and Modeling Software System
http://www.cse.ucsc.edu/research/compbio/sam.html

Citations (SAM, SAM-T99, HMMs)

Sequence numbers correspond to the following labels:

    • T0133 HIP1R N-terminal domain, rat
    • gi|12718814|dbj|BAB32404.1|_13:324 (AB005052) huntingtin interacting protein 1 related [Rattus norvegicus]
    • gi|13431575sp|Q9JKY5|HIPR_MOUSE_1:312 Huntingtin interacting protein 1 related (Hip1-related)
    • gi|6979938|gb|AAF34662.1|AF221713_1 (AF221713) huntingtin interacting protein 1 related [Mus musculus]
    • gi|12852463|dbj|BAB29420.1|_1:312 (AK014542) data source:MGD, source key:MGI:1352504, evidence:ISS~huntingtin interacting protein 1 related~putative [Mus musculus]
    • gi|14760485|ref|XP_038791.1|_1:312 (XM_038791) huntingtin interacting protein-1-related [Homo sapiens]
    • gi|13431563sp|O75146|HIPR_HUMAN Huntingtin interacting protein 1 related (Hip1-related) (Hip 12)
    • gi|3327124|dbj|BAA31630.1|_16:327 (AB014555) KIAA0655 protein [Homo sapiens]
    • gi|13431562sp|O00291|HIP1_HUMAN_2:279 Huntingtin interacting protein 1 (HIP-I)
    • gi|3510693|gb|AAC33564.1| (AF052288) huntingtin interacting protein 1 [Homo sapiens]
    • gi|17556913|ref|NP_498924.1|_8:296 (NM_066523) Talin [Caenorhabditis elegans]
    • gi|15055449|gb|AAA28205.2| (M98552) Hypothetical protein ZK370.3a [Caenorhabditis elegans]
    • gi|17556911|ref|NP_498925.1|_8:296 (NM_066524) ZK370.3b.p [Caenorhabditis elegans]
    • gi|15967136|gb|AAL11480.1|M98552_3 (M98552) Hypothetical protein ZK370.3b [Caenorhabditis elegans]
    • gi|2506215sp|P33338|SLA2_YEAST_3:272 SLA2 protein (Transmembrane protein MOP2)
    • gi|311413|emb|CAA80464.1| (Z22811) synthetical lethal with ABP1,#2 [Saccharomyces cerevisiae]
    • gi|6324086|ref|NP_014156.1|_3:272 (NC_001146) Protein involved in membrane cytoskeleton assembly, required for cell polarization and endocytosis; Sla2p [Saccharomyces cerevisiae]
    • gi|2131223|pir||S63211 cytoskeleton assembly control protein SLA2 - yeast (Saccharomyces cerevisiae)
    • gi|1302280|emb|CAA96149.1| (Z71519) ORF YNL243w [Saccharomyces cerevisiae]
    • gi|870732|gb|AAA74726.1|_3:272 (L12352) transmembrane protein [Saccharomyces cerevisiae]
    • gi|7493774|pir||T18255_7:268 cytoskeleton assembly control protein - yeast (Candida albicans)
    • gi|4033834|emb|CAA08750.1| (AJ009556) cytoskeleton assembly control protein Sla2p [Candida albicans]
    • gi|19114981|ref|NP_594069.1|_4:281 (NC_003424) homolog of yeast SLA2 protein-involved in membrane cytoskeleton assembly, cell polarization, and the internalization phase of endocytosis [Schizosaccharomyces pombe]
    • gi|7768486|emb|CAB90777.1| (AL355632) homolog of yeast SLA2 protein-involved in membrane cytoskeleton assembly, cell polarization, and the internalization phase of endocytosis [Schizosaccharomyces pombe]
    • gi|17506539|ref|NP_493260.1|_2:277 (NM_060859) F08A8.6.p [Caenorhabditis elegans]
    • gi|7498590|pir||T20573 hypothetical protein F08A8.6 - Caenorhabditis elegans
    • gi|3875647|emb|CAB16869.1| (Z99710) contains similarity to Pfam domain: PF01417 (ENTH domain), Score=171.6, E-value=4.3e-48, N=1 [Caenorhabditis elegans]
    • gi|7493908|pir||T30177_8:284 cytoskeleton assembly control protein homolog Sla2 - yeast (Yarrowia lipolytica)
    • gi|3978134|gb|AAC83184.1| (U65409) Sla2p [Yarrowia lipolytica]
    • gi|15242060|ref|NP_200530.1|_26:310 (NM_125102) putative protein [Arabidopsis thaliana]
    • gi|8777353|dbj|BAA96943.1| (AB019233) gene_id:MJB24.1~pir||T04249~strong similarity to unknown protein [Arabidopsis thaliana]
    • gi|18379261|ref|NP_565267.1|_29:320 (NM_126221) expressed protein [Arabidopsis thaliana]
    • gi|15983438|gb|AAL11587.1|AF424593_1 (AF424593) At2g01600/F2I9.22 [Arabidopsis thaliana]
    • gi|20197399|gb|AAM15059.1| (AC005560) expressed protein [Arabidopsis thaliana]
    • gi|20465612|gb|AAM20138.1| (AY096639) unknown protein [Arabidopsis thaliana]
    • gi|7294543|gb|AAF49884.1|_3:254 (AE003540) CG10971 gene product [alt 1] [Drosophila melanogaster]
    • gi|7294544|gb|AAF49885.1| (AE003540) CG10971 gene product [alt 2] [Drosophila melanogaster]
    • gi|17979069|gb|AAL49802.1|_26:318 (AY070045) unknown protein [Arabidopsis thaliana]
    • gi|20465327|gb|AAM20067.1| (AY096427) putative protein destination factor [Arabidopsis thaliana]
    • gi|15223949|ref|NP_172944.1|_29:316 (NM_101360) unknown protein [Arabidopsis thaliana]
    • gi|20465421|gb|AAM20134.1| (AY096496) unknown protein [Arabidopsis thaliana]
    • gi|7427515|ref|NP_005329.2|_2:198 (NM_005338) huntingtin interacting protein 1 [Homo sapiens]
    • gi|14782037|ref|XP_034769.1| (XM_034769) huntingtin interacting protein 1 [Homo sapiens]
    • gi|20542339|ref|XP_167504.1| (XM_167504) hypothetical protein XP_167504 [Homo sapiens]
    • gi|2072423|gb|AAC51257.1| (U79734) huntingtin interacting protein 1 [Homo sapiens]
    • gi|15236060|ref|NP_194324.1|_26:291 (NM_118727) predicted protein destination factor [Arabidopsis thaliana]
    • gi|7485840|pir||T04249 hypothetical protein F20B18.50 - Arabidopsis thaliana
    • gi|4538923|emb|CAB39659.1| (AL049483) predicted protein destination factor [Arabidopsis thaliana]
    • gi|7269445|emb|CAB79449.1| (AL161564) predicted protein destination factor [Arabidopsis thaliana]
    • gi|20342464|ref|XP_110571.1|_2:197 (XM_110571) RIKEN cDNA 2610109B09 [Mus musculus]
    • gi|17028404|gb|AAH17516.1|AAH17516 (BC017516) Similar to huntingtin interacting protein 1 [Mus musculus]
    • gi|8778222|gb|AAF79231.1|AC006917_16_29:383 (AC006917) F10B6.32 [Arabidopsis thaliana]
    • gi|3721836|dbj|BAA33713.1|_1:134 (AB013384) HIP1R [Homo sapiens]
    • gi|6321681|ref|NP_011757.1|_9:223 (NC_001139) Yeast Assembly Polypeptide, member of AP180 protein family, binds Pan1p and clathrin; Yap1802p [Saccharomyces cerevisiae]
    • gi|1723758sp|P53309|YG54_YEAST HYPOTHETICAL 64.3 KD PROTEIN IN PFK1-TDS4 INTERGENIC REGION
    • gi|2132626|pir||S64567 probable membrane protein YGR241c - yeast (Saccharomyces cerevisiae)
    • gi|1323437|emb|CAA97270.1| (Z73026) ORF YGR241c [Saccharomyces cerevisiae] 
              10        20        30        40        50            60 
              |         |         |         |         |             | 
   1 MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINSQEAPVKEKHARRIILGTH....HE
   2 MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINSQEAPVKEKHARRIILGTH....HE
   3 MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINSQEAPVKEKHARRIILGTH....HE
   4 MNSIKNVPARVLSRTPGHSLEAEREQFDKTQAISISKAINSQEAPVKEKHARRIILGTH....HE
   5 MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTH....HE
   6 MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTH....HE
   7 ----------------------------------INKAINTQEVAVKEKHARTCILGTH....HE
   8 -----------------------REVFVRAQLEAVQKAITKNEVPLKPKHARTIIVGTH....KE
   9 -----------------------REVFVRAQLEAVQKAITKNEVPLKPKHARTIIVGTH....KE
  10 -----------------------REVFVRAQLEAVQKAITKNEVPLKPKHARTIIVGTH....KE
  11 -------------------------RIDSDLQKALKKACSVEETAPKRKHVRACIVYTW....DH
  12 -------------------------RIDSDLQKALKKACSVEETAPKRKHVRACIVYTW....DH
  13 -------------------------RIDSDLQKALKKACSVEETAPKRKHVRACIVYTW....DH
  14 -----------------------------DLQTSVKKACNADEVPPKRKHVRACIVYTW....DH
  15 ---------------------------DASLMTSVRKATSIDETAPKRKHVRSCIIFTW....DH
  16 ----------------------DRDAFFRGQFQAVQKAITKDETPLKPKHLETILLGTH....TE
  17 ----------------------------VDLNVNIKKATNTDESAPKRKHVRACIVYTH....DH
  18 ------------------------NSEFKDLDIAIVKATNHVESPPKERHVRKIFSATSviqpRA
  19 ---------------------------YADLDVAIVKATNHVECPPKDRHLRKIFAATSvtraRA
  20 ----------------------------------------------------------H....KA
  21 ------------------------NSEFKDLDVAIVKATNHVESAPKERHIRRIFSATSvvqpRA
  22 ---------------------------YAELDVAIVKATNHVECPPKDRHLRKIFLATSairpRA
  23 -----------------------------------------------------------....--
  24 ------------------------NSEFKDLDVAIVKATNHVESAPKERHIRRIFSATSvvqpRA
  25 -----------------------------------------------------------....--
  26 ---------------------------YAELDVAIVKATNHVECPPKDRHLRKIFLATSairpRA
  27 -----------------------------------------------------------....--
  28 ----------------------------------VKGATKIKMAPPKQKYVDPILSGTS....SA


             70        80        90       100         110       120    
             |         |         |         |           |         |    
   1 KGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDC..QRYRSNIREIGDLWGHLR.
   2 KGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDC..QRYRSNIREIGDLWGHLR.
   3 KGAFTFWSYAIGLPLSSSSILSWKFCHVLHKVLRDGHPNVLHDY..QRYRSNIREIGDLWGHLR.
   4 KGAFTFWSYAIGLPLSSSSILSWKFCHVLHKVLRDGHPNVLHDY..QRYRSNIREIGDLWGHLR.
   5 KGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDC..QRYRSNIREIGDLWGHLH.
   6 KGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDC..QRYRSNIREIGDLWGHLH.
   7 KGAQTFWSVVNRLPLSSNPVLCWKFCHVFHKLLRDGHPNVLKDS..LRYRNELSDMSRMWGHLS.
   8 KSSGIFWHTVGRIQLEKHPVLTWKFCHLVHKLLRDGHRKVPEET..YRYVNRFTQLSQFWKHLNt
   9 KSSGIFWHTVGRIQLEKHPVLTWKFCHLVHKLLRDGHRKVPEET..YRYVNRFTQLSQFWKHLNt
  10 KSSGIFWHTVGRIQLEKHPVLTWKFCHLVHKLLRDGHRKVPEET..YRYVNRFTQLSQFWKHLNt
  11 QSSKAVFTTLKTLPLANDEVQLFKMLIVLHKIIQEGHPSALAEA..IRDRDWIRSLGRVHSGGS.
  12 QSSKAVFTTLKTLPLANDEVQLFKMLIVLHKIIQEGHPSALAEA..IRDRDWIRSLGRVHSGGS.
  13 QSSKAVFTTLKTLALANDEVQLFKMLIVLHKIIQEGHPSALAEA..IRDRDWIRSLGRVHSGGS.
  14 KNSRAFWNAVKIQPLQSNEVQLFKALIMIHKVLQEGHPNTLKDG..YRNRDFIASLATVFPSHG.
  15 HTARPFWTAIKVQPLLANEVQTFKALITIHRVLQEGHKSALVDS..QSEKGWLKTCERQYDGESs
  16 KSSAIFWSSVKKIKLENHPVLTWKFCLLVHKLLRDGHPVVPKEA..YRNEKRFTQLALHWKDKR.
  17 RSSKAFWNGIRIQPLQTDDVMVFKALITIHKVLQEGHPSALRDA..QANVNFIQSLARGNNYTGp
  18 DVAYCIHALSKRLSKTRNWVVAMKVLIVIHRTLREGDPTFREELlnYSHRRHILRISNFKDDTSp
  19 DVAYCIHALSRRLHKTRNWTVALKTLIVIHRLLREGDPTFREELlnFSQRGRILQLSNFKDDSSp
  20 KEAKTFWMIISRQPLMQSRFTAWKFSHLLHKVLREGHESAIRHS..QSHKKMILEVGKMWGLLQ.
  21 DVAYCIHALAKRLSKTRNWVVAIKVLIVIHRTLREGDPTFREELlnYSHRGHILRISNFKDDTSp
  22 DVAYCIHALSRRLHKTRNWTVALKALLVIHRLLRDGDPTFREELlnFSQKGRIMQISNFKDDSSp
  23 --------------------------------------------..----------SRMWGHLS.
  24 DVAYCIHALAKRLSKTRNWVVAIKVLIVIHRTLREGDPTFREELlnYSHRGHILRISNFKDDTSp
  25 --------------------------------------------..----------SRMWGHLS.
  26 DVAYCIHALSRRLHKTRNWTVALKALLVIHRLLRDGDPTFREELlnFSQKGRIMQISNFKDDSSp
  27 --------------------------------------------..------------------.
  28 RGLQEITHALDIRLSDTAWTIVYKALIVLHLMIQQGEKDVTLRH..YSHNLDVFQLRKISHTTK.


                130       140       150       160        170           
                 |         |         |         |          |           
   1 ....DQYGHL..VNIYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAA.GTDVNN.....IFQLT
   2 ....DQYGHL..VNIYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAA.GTDVNN.....IFQLT
   3 ....DQYGHL..VNIYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAA.GTDVNN.....IFQLT
   4 ....DQYGHL..VNIYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAA.GTDVNN.....IFQLT
   5 ....DRYGQL..VNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAA.GTDVNN.....IFQLT
   6 ....DRYGQL..VNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAA.GTDVNN.....IFQLT
   7 ....EGYGQL..CSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAG.ESDVNN.....FFQLT
   8 ....SGYGPC..IESYCKLLHDRVTFHNKYPVVPGKLDLNDSQL-KTL.EGDLDN.....MFEMT
   9 ....SGYGPC..IESYCKLLHDRVTFHNKYPVVPGKLDLNDSQL-KTL.EGDLDN.....MFEMT
  10 ....SGYGPC..IESYCKLLHDRVTFHNKYPVVPGKLDLNDSQL-KTL.EGDLDN.....MFEMT
  11 ....S-YSKL..IREYVRYLVLKLDFHAHHRGFNNGTFEYEEYVSLVS.VSDPDE.....GYETI
  12 ....S-YSKL..IREYVRYLVLKLDFHAHHRGFNNGTFEYEEYVSLVS.VSDPDE.....GYETI
  13 ....S-YSKL..IREYVRYLVLKLDFHAHHRGFNNGTFEYEEYVSLVS.VSDPDE.....GYETI
  14 ....SAYGRL..INQYDKYILQKLDFHRNNPGFNGTFEYE-EYISLRA.VNDPNE.....GYEAL
  15 p...KGYSDL..IRDYVDYLLDKLSFHAQHPEFNGTFEYK-EYISLRQ.VDDPNE.....GYETV
  16 ....D-YGPC..IDAYCKLLHDRVIFHHKRPYFPGNLFVSPLQLD-TM.GRDLSR.....MLRLT
  17 nqgnHGYGKL..ISEYVRFLMQKLTFHKYHPAFNGMFEYED-YISLRT.VNDPNE.....GYEAI
  18 la..WDCSAW..VRTYALFLEERLECYRVLK-----YDIEAERLPKAS.GAASKT.....HRTRM
  19 ia..WDCSAW..VRTYALFLEERLECFRVLK-----YDTEAERLPKSNpGQDKGY.....SRTRD
  20 ....DDIGCC..IQAYSKLLATKLNFHDKNRMFPGTLNISFTELFIAV.DRDLNY.....CFQLC
  21 la..WDCSAW..IRTYALFLEERLECYRVLK-----YDIEAERLPKGS.GASSKNvd8qtYRTRM
  22 va..WDCSGW..VRTYALFLEERLECFRVLK-----YDIEAERLPKVSpGQEKGY.....SKTRD
  23 ....EGYGQL..CSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAG.ESDVNN.....FFQLT
  24 la..WDCSAW..IRTYALFLEERLECYRVLK-----YDIEAERLPKGS.GASSKNvd8qtYRTRM
  25 ....EGYGQL..CSIYLKLLRTRMEYHTKNPRFPGNLQMSDRQLDEAG.ESDVNN.....FFQLT
  26 42taWDCSGW..VRTYALFLEERLECFRVLK-----YDIEAERLPKVSpGQEKGY.....SKTRD
  27 ....------..------------------------------------.------.....-----
  28 ....WSSNDMraLQRYDEYLKTRCEEYGRLGMDHLRDNYSSLKL----.------.....GSKNQ


       180       190       200             210       220       230     
        |         |         |               |         |         |     
   1 VEMFDYMDCELKLSESVFRQLNTA.IAV.....SQMSSGQCRLAPLIQVIQDCSHLYHYT.....
   2 VEMFDYMDCELKLSESVFRQLNTA.IAV.....SQMSSGQCRLAPLIQVIQDCSHLYHYT.....
   3 VEMFDYMDCELKLSESVFRQLNTA.IAV.....SQMSSGQCRLAPLIQVIQDCSHLYHYT.....
   4 VEMFDYMDCELKLSESVFRQLNTA.IAV.....SQMSSGQCRLAPLIQVIQDCSHLYHYT.....
   5 VEMFDYMDCELKLSESVFRQLNTA.IAV.....SQMSSGQCRLAPLIQVIQDCSHLYHYT.....
   6 VEMFDYMDCELKLSESVFRQLNTA.IAV.....SQMSSGQCRLAPLIQVIQDCSHLYHYT.....
   7 VEMFDYLECELNLFQTVFNSLDMS.RSV.....SVTAAGQCRLAPLIQVILDCSHLYDYT.....
   8 IDMLDQMDALLVLQDRVYEMMNSL.RWN.....SLIPQGQCMLSPLIIAILDTSKFYDYL.....
   9 IDMLDQMDALLVLQDRVYEMMNSL.RWN.....SLIPQGQCMLSPLIIAILDTSKFYDYL.....
  10 IDMLDQMDALLVLQDRVYEMMNSL.RWN.....SLIPQGQCMLSPLIIAILDTSKFYDYL.....
  11 LDLMSLQDSLDEFSQIIFASIQSE.R--.....---RNTECKISALIPLIAESYGIYKFI.....
  12 LDLMSLQDSLDEFSQIIFASIQSE.R--.....---RNTECKISALIPLIAESYGIYKFI.....
  13 LDLMSLQDSLDEFSQIIFASIQSE.R--.....---RNTECKISALIPLIAESYGIYKFI.....
  14 LNLMDLQDSINDLQKLIFATINQS.H--.....----SNLCKVSALVPLIAESYGIYKFC.....
  15 YDMMNLQDHIDEFQKQLFSNFKRS.N--.....----KNECRIAALVPLVQESYGIYRFL.....
  16 GDMMHQMDSLLAFQEKVYLLSNSSpRWD.....PNTPQGQCLMLPLISVIMDTWPFFIYI.....
  17 MNLMTLQDGVDDFQRLVFSSLQRS.R--.....----SNECKISSLVPMIAESYGIYRFV.....
  18 LSGEDLLEQLPALQQLLYRLIGCQ.PEG.....AAY-SNYLIQYALALVLKESFKIYCAInd7nl
  19 LDGEELLEQLPALQQLLYRLIGCR.PEG.....AAN-HNHVIQYALALVLKESFKVYCAInd7nl
  20 VEIFDYLEDIIALQLTIFSSMEKY.RMS.....SMTPQGQCRLAPIVCLIQDSNALYDLS.....
  21 LSDEELLEQLPALQQLLYRLIGCQ.PEG.....SAY-SNYLIQYALALVLKESFKIYCAInd7nl
  22 LDGEKLLEQLPALQQLLHRLIGCK.PEG.....AAK-HNHIIQYALSLVLKESFKVYCAIne7nl
  23 VEMFDYLECELNLFQTVFNSLDMS.RSV.....SVTAAGQCRLAPLIQVILDCSHLYDYT.....
  24 LSDEELLEQLPALQQLLYRLIGCQ.PEG.....SAY-SNYLIQYALALVLKESFKIYCAInd7nl
  25 VEMFDYLECELNLFQTVFNSLDMS.RSV.....SVTTAGQCRLAPLIQVILDCSHLYDYT.....
  26 LDGEKLLEQLPALQQLLHRLIGCK.LFLt14peGAAKHNHIIQYALSLVLKESFKVYCAIn23sl
  27 --MFDYMDCELKLSESVFRQLNTA.IAV.....SQMSSGQCRLAPLIQVIQDCSHLYHYT.....
  28 LSMDEELDHVESLEIQINALIRNK.YSV.....SDL-ENHLLLYAFQLLVQDLLGLYNALne7tl


             240           250                 260       270       280 
              |             |                   |         |         | 
   1 VKLMFKLHSCLP....ADTLQGHRD.....RFHE.....QFHSLRNFFRRASDMLYFKRLIQIPR
   2 VKLMFKLHSCLP....ADTLQGHRD.....RFHE.....QFHSLRNFFRRASDMLYFKRLIQIPR
   3 VKLMFKLHSCLP....ADTLQGHRD.....RFHE.....QFHSLKNFFRRASDMLYFKRLIQIPR
   4 VKLMFKLHSCLP....ADTLQGHRD.....RFHE.....QFHSLKNFFRRASDMLYFKRLIQIPR
   5 VKLLFKLHSCLP....ADTLQGHRD.....RFHE.....QFHSLRNFFRRASDMLYFKRLIQIPR
   6 VKLLFKLHSCLP....ADTLQGHRD.....RFHE.....QFHSLRNFFRRASDMLYFKRLIQIPR
   7 VKLLFKLHSCLP....ADTLQGHRD.....RFME.....QFTKLKDLFYRSSNLQYFKRLIQIPQ
   8 VKMIFKLHSQVP....PDALEGHRS.....RFRT.....IFERTKKFYEESSNLQYFKYLVSIPT
   9 VKMIFKLHSQVP....PDALEGHRS.....RFRT.....IFERTKKFYEESSNLQYFKYLVSIPT
  10 VKMIFKLHSQVP....PDALEGHRS.....RFRT.....IFERTKKFYEESSNLQYFKYLVSIPT
  11 TSMLRAMHRQLNdaegDAALQPLKE.....RYEL.....QHARLFEFYADCSSVKYLTTLVTIPK
  12 TSMLRAMHRQLNdaegDAALQPLKE.....RYEL.....QHARLFEFYADCSSVKYLTTLVTIPK
  13 TSMLRAMHRQLNdaegDAALQPLKE.....RYEL.....QHARLFEFYADCSSVKYLTTLVTIPK
  14 ISMLRAMYQQLGe...DDALSGLVE.....RFDS.....QHFMLRDFYTDCHAIKFLTSLITIPR
  15 TSMLRALYSTVDa...PETLEPLKH.....RYKS.....QHHRLRQFYADCSNLRYLTSLISVPR
  16 VRMMYNLHSNVS....PHELEGYRS.....RFQT.....IFEKTKQFYEECSKHQYFRCFVQIPT
  17 ISMLRAMHVSTGn...DEALESLRQ.....RFYS.....QHDRLRDFYYDCSTLKYLRSIVTIPQ
  18 VDMFFEMSRHDA....VKALNIYK-.....RAGQ.....QAENLAEFYDYCKGLELARNF-QFPT
  19 IDKFFEMAKHEA....ITSLEIYK-.....RAGQ.....QARSLSDFYEACKGLELARNF-QFPV
  20 VRLMFKLHDGVP....YDVVSGHRD.....RFHG.....LFLKLKSFYNNVRPLQYFKDLITIPE
  21 VDMFFEMSRHDA....VKALNIYK-.....RAGQ.....QAENLADFYEYCKGLELARNF-QFPT
  22 VEKFFEMPRHEA....IKALEIYK-.....RAGL.....QAGNLSAFYEVCKGLELARNF-QFPV
  23 VKLLFKLHSCLP....ADTLQGHRD.....RFME.....QFTKLKDLFYRSSNLQYFKRLIQIPQ
  24 VDMFFEMSRHDA....VKALNIYK-.....RAGQ.....Q-------------------------
  25 VKLLFKLHSCLP....ADTLQGHRD.....RFME.....QFTKLKDLFQRSSNLQYFKRLIQIPQ
  26 PSCFFEMPRHEA....IKALEIYKRa11qfRFHLtr7smQAGNLSAFYEVCKGLELARNF-QFPV
  27 VKLLFKLHSCLP....ADTLQGHRD.....RFHE.....QFHSLRNFFRRASDMLYFKRLIQIPR
  28 LESFFELSIEHA....KRTLDLYKD.....----.....--------------------------


            290       300       310  
             |         |         |  
   1 LPEGPPNFLRASALAEHIKPVVVIPEEAPEE
   2 LPEGPPNFLRASALAEHIKPVVVIPEEAPEE
   3 LPEGPPNFLRASALAEHIKPVVVIPEEAPEE
   4 LPEGPPNFLRASALAEHIKPVVVIPEEAPEE
   5 LPEGPPNFLRASALAEHIKPVVVIPEEAPED
   6 LPEGPPNFLRASALAEHIKPVVVIPEEAPED
   7 LPENPPNFLRASALSEHISPVVVIPAEASSP
   8 LPSHAPNFLQQSDLESYRTPHAYLHSEGSED
   9 LPSHAPNFLQQSDLESYRTPHAYLHSEGSED
  10 LPSHAPNFLQQSDLESYRTPHAYLHSEGSED
  11 LPVDAPDVFLINDVDE---------------
  12 LPVDAPDVFLINDVDE---------------
  13 LPVDAPDVFLINDVDE---------------
  14 LPNSAPNLKVTDDGQP---------------
  15 LPHDPPDLEGDDNIPDLPKRPASIAPQP---
  16 FPLHAPNFFTQSDLESYQ-------------
  17 LGKNPPNLLEEEDGPGLPQRPKSVA------
  18 LRQPPPSFLA--TMEEYIKEAP---------
  19 LREPPQSFLT--TMEEYIKEAPRVVDVPAEP
  20 LPDSSPNFKSQNDFTSYVPPVVHVPQEPD--
  21 LRQPPPSFLA--TMEDYIKEAP---------
  22 LREPPQSFLT--TMEEYMRDAPQMVDV----
  23 LPENPPNFLRASALSEHISPVVVIPAEASSP
  24 ---PPPSFLA--TMEDYIKEAP---------
  25 LPENPPNFLRASALSEHISPVVVIPAEVSS-
  26 LRE----------------------------
  27 LPEGPPNFLRASALAEHIKPVVVIPEEAPED
  28 -------------------------------