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Date: Wed, 5 Jul 2000 12:27:47 -0700
From: UCSC Computational Biology <farmer@cse.ucsc.edu>
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Subject: T0106(target 99 alignment)
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The following is the Target99 alignment in the formats you requested.

Citation:  
  K. Karplus, C. Barrett, and R. Hughey,
  Hidden Markov Models for Detecting Remote Protein Homologies,
  Bioinformatics, 1998, vol. 14, no. 10, pp. 846-856. 
  http://www.cse.ucsc.edu/resesarch/compbio/HMM-apps
--------------------------------------------------------

For questions or problems, please see the SAM-T99 FAQ at

http://www.cse.ucsc.edu/research/compbio/HMM-apps/sam-t99-faq.html

or email us at sam-info@cse.ucsc.edu


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>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSPDLLFFLCAMY
APICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPESLACDELPVYDRGVCISPEA
IVTADGAD


>gi|4335927|gb|AAD17520.1|_31:156   (AF060696) frizzled 8b protein [Danio rerio]
mdsptqgthwsalalcvlllwssvcgrehv--CQEISVPLCRGIGYNYTY
MPNQFNHDNQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLED-YK
KPLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGDPntLCMDY
NRTDATSSP-aapkttsrpgkpfkrknksspgssscepecycrapmvpvh
sdhhplynrv
>gi|3983449|gb|AAC83940.1|_31:156   (AF039410) frizzled homolog [Danio rerio]
mdsptqgthwsalalcvlllwssvcgrehv--CQEISVPLCRGIGYNYTY
MPNQFNHDNQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLED-YK
KPLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGDPntLCMDY
NRTDATSSP-aapkttsrpgkpfkrknksspgssscepecycrapmvpvh
sdhhplynrv
>gi|4585283|gb|AAD25360.1|AF117390_1_31:156   (AF117390) frizzled protein; fz6 [Danio rerio]
mdsptqgthwsalalcvlllwssvcgrehv--CQEISVPLCRGIGYNYTY
MPNQFNHDNQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLED-YK
KPLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGDPntLCMDY
NRTDATSSP-aapkttsrpgkpfkrknksspgssscepecycrapmvpvh
sdhhplynrv
>gi|3323438|gb|AAC31121.1|_28:149   (AF017177) frizzled 8 protein; Xfz8 [Xenopus laevis]
meslslsllllvswlqgsqcaaakels--CQEITVPLCKDIGYNYTYMPN
QFNHDTQDEAGMEVHQFWPLVVIHCSPDLKFFLCSMYTPICLED-YKKPL
PPCRSVCERARAGCAPLMRQYGFAWPDRMRCDRLPEQGNPdtLCMDYYNR
TE-----qttaapshpeppkpparsvpkgrtrvepprsrsratgcesgcq
crapmvq
>gi|6679887|ref|NP_032084.1|_34:153   frizzled homolog 8 (Drosophila)
gi|1151260|gb|AAC52433.1| (U43321) transmembrane receptor [Mus musculus]
mewgyllevtsllaalavlqrssgaaaasakel-ACQEITVPLCKGIGYN
YTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLED
-YKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPdtLC
MDYNR--------tdlttaapspprrlppppppgeqppsgsghsrppgar
pphrggssrgsgd
>gi|3869266|gb|AAC77361.1|_30:151   (AF033110) frizzled-8 [Xenopus laevis]
mecpylsllllvlvsglqgsqsaaakels--CQEITVPLCKDIGYNYTYM
PNQFNHDTQDEAGMEVHQFWPLVVIHCSPDLKFFLCSMYTPICLED-YKK
PLPPCRSVCERARAGCAPLMRQYGFAWPDRMRCDRLPEQSNPdtLCMDYY
NRTE-----qttaapshpeppkpparsvpksrtraepprsrsrapgcesg
cqcrapmvq
>gi|4503829|ref|NP_003459.1|_33:159   frizzled 5; Wnt receptor
gi|1151252|gb|AAC50385.1| (U43318) transmembrane receptor [Homo sapiens]
marpdpsappsllllllaqlvgraaaaskapv--CQEITVPMCRGIGYNL
THMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCTMYTPICLPD-
YHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDaevLC
MDYNRSEATTAP-prpfpakptlpgppgapasggecpaggpfvckcrepf
vpilkeshplynk
>gi|4585281|gb|AAD25359.1|AF117389_1_30:148   (AF117389) frizzled protein; fz5 [Danio rerio]
mecyllgiylflalallprssgttakeit--CQEIAVPLCKGIGYNYTYM
PNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLED-YKK
PLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGAPdtLCMDYN
R--------tdsttvspvlskptnypskainphkkksgrpgvgpnknkpc
epgcqcrap
>gi|6649950|gb|AAF21645.1|AF039412_1_30:148   (AF039412) frizzled homolog [Danio rerio]
mecyllgiylflalallprscgttakeit--CQEIAVPLCKGIGYNYTYM
PNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLED-YKK
PLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGAPdtLCMDYN
R--------tdsttvspvlskptnypskainphkkksgrpgvgpnknkpc
epgcqcrap
>gi|4164471|gb|AAD05435.1|_30:148   (AF060697) frizzled 8a protein [Danio rerio]
mecyllgiylflalallprssgttakeit--CQEIAVPLCKGIGYNYTYM
PNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLED-YKK
PLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGAPdtLCMDYN
R--------tdsttvspvlskptnypskainphkkksgrpgvgpnknkpc
epgcqcrap
>gi|1518051|gb|AAC47273.1|_63:190   (U65589) Dfz2 [Drosophila melanogaster]
lvllltscradgplhsadhgmggmgmgghgldaspapgygvpaipkdpnl
-RCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSP
DLKFFLCSMYTPICLED-YHKPLPVCRSVCERARSGCAPIMQQYSFEWPE
RMACEHLPLHGDPdnLCMEQPSYTEAGSGGssggsggsgsgsgsggkrkq
ggsgsggsgaggssgststkpcrgrnsknc
>gi|7451362|pir||S71786_63:190   wingless receptor precursor dfz2 - fruit fly (Drosophila melanogaster)
lvllltscradgplhsadhgmggmgmgghgldaspapgygvpaipkdpnl
-RCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSP
DLKFFLCSMYTPICLED-YHKPLPVCRSVCERARSGCAPIMQQYSFEWPE
RMACEHLPLHGDPdnLCMEQPSYTEAGSGGssggsggsgsgsgsggkrkq
ggsgsggsgaggssgststkpcrgrnsknc
>gi|7293818|gb|AAF49184.1|_63:190   (AE003518) fz2 gene product [Drosophila melanogaster]
lvllltscradgplhsadhgmggmgmgghgldaspapgygvpvipkdpnl
-RCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSP
DLKFFLCSMYTPICLED-YHKPLPVCRSVCERARSGCAPIMQQYSFEWPE
RMACEHLPLHGDPdnLCMEQPSYTEAGSGGssggsggsgsgsgsggkrkq
ggsgsggsgaggssgststkpcrgrnsknc
>gi|6746600|gb|AAF27643.1|AF218057_1_25:152   (AF218057) Frzb [Gallus gallus]
mwrglpalalaallllgrapagraAACEPVRIPLCKPLPWNMTKMPNHLH
HSTQANAVLAMEQFEGLLGTNCSPDLLFFLCAMYAPICTIDFQHEPIKPC
KSVCERARAGCEPVLIRYRHAWPESLACDELPLYDRGVCISPEAIVTAEG
ADfpmdsnngncrgtgierckckpikatqktylrnnynyvirakvkevkt
kc
>gi|6755476|ref|NP_035486.1|_33:160   secreted frizzled-related sequence protein 3
gi|1688097|gb|AAC53135.1| (U68058) frezzled [Mus musculus]
gi|1917011|gb|AAB51300.1| (U91905) Fritz [Mus musculus]
gi|1946345|gb|AAC53147.1| (U88568) secreted frizzled related protein sFRP-3 [Mus musculus]
mvccgpgrmllgwagllvlaalcllqvpgaqaAACEPVRIPLCKSLPWNM
TKMPNHLHHSTQANAILAMEQFEGLLGTHCSPDLLFFLCAMYAPICTIDF
QHEPIKPCKSVCERARQGCEPILIKYRHSWPESLACDELPVYDRGVCISP
EAIVTADGADfpmdsstghcrgasserckckpvratqktyfrnnynyvir
akvkevkmkc
>gi|4503833|ref|NP_003498.1|_47:173   frizzled 7
gi|7451365|pir||JE0339 Frizzled-7 protein - human
gi|3927887|dbj|BAA34668.1| (AB017365) frizzled-7 [Homo sapiens]
mrdpgaaaplsslglcalvlallgalsagagaqpyhgekgisvpdhGFCQ
PISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRF
FLCSMYAPVCTV--LDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRC
ENFPVHGAGeICVGQNTSDGSGGPGggptayptapylpdlpftalppgas
dgrgrpafpfscprqlkvppylgyr
>gi|3434981|dbj|BAA32424.1|_47:173   (AB010881) FzE3 [Homo sapiens]
mrdpgaavplsslgfcalvlallgalsagagaqpyhgekgisvpdhGFCQ
PISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRF
FLCSMYAPVCTV--LDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRC
ENFPVHGAGeICVGQNTSDGSGGPGggptayptapylpdlpftalppgas
dgkgrpafpfscprqlkvppylgyr
>gi|1688095|gb|AAC51217.1|_33:160   (U68057) frezzled [Homo sapiens]
mvcgspggmlllragllalaalcllrvpgaraAACEPVRIPLCKSLPWNM
TKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDF
QHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISP
EAIVTADGADfpmdssngncrgasserckckpiratqktyfrnnynyvir
akvkeiktkc
>gi|1620539|gb|AAC48662.1|_33:160   (U24164) Frzb precursor [Bos taurus]
mvcgsrggmlllpagllalaalcllrvpgaraAACEPVRIPLCKSLPWNM
TKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDF
QHEPIKPCKSVCERARQGCEPILIKYRHSWPESLACEELPVYDRGVCISP
EAIVTADGADfpmdssngncrgasserckckpvratqktyfrnnynyvir
akvkeiktkc
>gi|1917007|gb|AAB51298.1|_33:160   (U91903) Fritz [Homo sapiens]
mvcgspggmlllragllalaalcllrvpgaraAACEPVRIPLCKSLPWNM
TKMPNHLHHSTQDNAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDF
QHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISP
EAIVTADGADfpmdssngncrgasserckckpiratqktyfrnnynyvir
akvkeiktkc
>gi|4503789|ref|NP_001454.1|_33:160   frizzled-related protein
gi|1620541|gb|AAC50736.1| (U24163) Frzb precursor [Homo sapiens]
mvcgspggmlllragllalaalcllrvpgaraAACEPVRIPLCKSLPWNM
TKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDF
QHEPINPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISP
EAIVTADGADfpmdssngncrgasserckckpiratqktyfrnnynyvir
akvkeiktkc
>gi|6679885|ref|NP_032083.1|_47:173   frizzled homolog 7 (Drosophila)
gi|1151258|gb|AAC52432.1| (U43320) transmembrane receptor [Mus musculus]
mrgpgtaashsplglcalvlallgalptdtraqpyhgekgisvpdhGFCQ
PISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRF
FLCSMYAPVCTV--LDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRC
ENFPVHGAGeICVGQNTSDGSGGAGgsptayptapylpdppftamspsdg
rgrlsfpfscprqlkvppylgyrfl
>gi|4545254|gb|AAD22462.1|AF116853_1_29:156   (AF116853) fzb-1 [Danio rerio]
mqnmfsyemficvlafaclleiprgtgaASCEPIRIPMCKSMPWNMTKMP
NHLHHSTQANAVLAIEQFEGLLGTQCSADLLFFLCAMYAPICTIDFQHDP
IKPCKSVCERAKCGCEPVMKRYNHTWPESLACEELPVYDRGVCISPEAIV
KAEGPDnsyyqdpakcnpegnpdfpmdshntnckgandrckcksvkfnqk
tysknn
>gi|7527456|gb|AAF63152.1|AF039215_1_35:160   (AF039215) transmembrane receptor frizzled-7 [Xenopus laevis]
msstvsllfcclflqlcpsaqqyhgekgisvpdhGFCQPISIPLCTDIAY
NQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV
--LEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGeIC
VGQNTSDNSPSG-ptarpspylpdsitfqphphrdftcprqlkvppylay
rflgekdcgapce
>gi|5815434|gb|AAD52671.1|_35:160   (AF179213) frizzled 7 [Xenopus laevis]
msstvsllfcglflqlcpsaqqyhgekgisvpdhGFCQPISIPLCTDIAY
NQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV
--LEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGeIC
VGQNTSDNSPSG-ptarpspylpdsitfqphphrdftcprqlkvppylay
rflgekdcgapce
>gi|5262975|emb|CAB45875.1|_35:160   (AJ243323) Frizzled 7 protein [Xenopus laevis]
msstvsllfcclflqlcpsaqqyhgekgisvpdhGFCQPISIPLCTDIAY
NQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV
--LEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGeIC
VGQNTSDNSPSG-ptarpspylpdsitfqphphrdftcprqlkvppylay
rflgekdcgapce
>gi|5524663|gb|AAD44331.1|_34:159   (AF159106) frizzled 7 [Xenopus laevis]
mlapvsllfclflqlcpsaqqyhgekgisvpdhGFCQPISIPLCTDIAYN
QTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-
-LEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGeICV
GQNTSDNSPSG-ptarptlnppdsitfqphphrdftcprqlkvppylgyr
flgekdcgapce
>gi|4469405|gb|AAD21247.1|_35:160   (AF114151) frizzled-7 [Xenopus laevis]
msstvsllfcclflqlcpsaqqyhgekgisvpdhGFCQPISIPLCTDIAY
NQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV
--LEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGeIC
VGQNTSDNSPSG-ptarpspylpdsitfqphphrdftcprqfkvppylay
rflgekdcgapce
>gi|4585277|gb|AAD25357.1|AF117387_1_45:160   (AF117387) frizzled protein; fz2 [Danio rerio]
mrkpadehhftmetsgmhlvgfwlhvlllfqlsglgdsaskdiv--CEPI
TVPMCKGIGYNHTYMPNQFNHDNQDEVGLEVHQFWPLVRIHCSPDLLFFL
CSMYTPICLQD-YKKPLPPCRSVCERAKRGCSPLMIQYGFEWPERMSCEQ
LPMLGDTdrLCMD-----------rnssetttlsppfpkptpkgtprhra
taksappqkcdrechcrgplvpik
>gi|7340126|gb|AAF61097.1|AF224317_1_45:171   (AF224317) Frizzled-7 [Gallus gallus]
mrpaageagaglrwlglaallaallgtpcaaahqddkaisvpdhGFCQPI
SIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFL
CSMYAPVCTV--LEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCEN
FPVHGAGeICVGQNTSDAPPGPGgaggrgataqptagylpdlltppqpaa
gfsfscprqlkvppylgyrflge
>gi|2655276|gb|AAB87969.1|_45:171   (AF031831) 7-transmembrane protein frizzled-7 [Gallus gallus]
mrpaageagaglrwlglaallaallgtpcaaahhedkaisvpdhGFCQPI
SIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFL
CSMYAPVCTV--LEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCEN
FPVHGAGeICVGQNTSDAPPGPGgaggrgataqptagylpdlltppqpaa
gfsfscprqlkvppylgyrflge
>gi|4503827|ref|NP_001457.1|_37:162   frizzled 2
gi|7451364|pir||JE0338 Frizzled-2 protein - human
gi|736679|gb|AAB46397.1| (L37882) polarity gene; putative [Homo sapiens]
gi|3927885|dbj|BAA34667.1| (AB017364) frizzled-2 [Homo sapiens]
mrprsalprlllpllllpaagpaqfhgekgisipdhGFCQPISIPLCTDI
AYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVC
TV--LEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEq
ICVGQNHSEDGAPA-llttapppglqpgaggtpggpggggappryatleh
pfhcprvlkvpsyls
>gi|8248134|gb|AAF74056.1|AF206321_1_42:167   (AF206321) frizzled 10 [Mus musculus]
mrarsalprsalprlllpllllpaagpaqfhgekgisipdhGFCQPISIP
LCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSM
YAPVCTV--LEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPR
HGAEqICVGQNHSEDGAPA-llttappsglqpgaggtpggpggggsppry
atlehpfhcprvlkvpsyls
>gi|5821259|dbj|BAA83742.1|_36:163   (AB023806) Frizzled-10 [Gallus gallus]
gi|7340132|gb|AAF61100.1|AF224320_1 (AF224320) Frizzled-10 [Gallus gallus]
mgpaagnlvravlalcwlaehcagissidierpgdGRCQPIEIPMCKDIG
YNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLKFFLCSLYAPMCT
EQ-VSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCSKLPNKNDPny
LCMEAPNNGSDEPP-rgssmlppmfrpqrpstghdlqqhkdslsrtscen
pgkfhhveksascap
>gi|7710094|ref|NP_057896.1|_24:147   secreted frizzled-related sequence protein 4
gi|4219090|gb|AAD12306.1| (AF117709) secreted frizzled-related sequence protein 4 [Mus musculus]
mlrsilvalclwlrlalgvrgap--CEAVRIPMCRHMPWNITRMPNHLHH
STQENAILAIEQYEELVDVNCSSVLRFFLCAMYAPICTLEFLHDPIKPCK
SVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLP-
-edvkwiditpdmmvqersfdadckrlspdrckckkvkptlatylsknys
y
>gi|2293564|gb|AAB65431.1|_24:147   (AF012891) frizzled related protein frpAP [Rattus norvegicus]
mllsilvalclcvrlalgvrgap--CEAVRIPMCRHMPWNITRMPNHLHH
STQENAILAIEQYEELVDVNCSSVLRFFLCAMYAPICTLEFLHDPIKPCK
SVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLP-
-edvkwiditpdmmvqersfdadckhlspdrckckkvkptlatylsknys
y
>gi|5524665|gb|AAD44332.1|_32:159   (AF159107) frizzled 9 [Xenopus laevis]
meprvvtalllslaaalcsgissinpdrsgeGRCQAIEIPMCKDIGYNMT
RMPNLMGHENQKEAAIQLHEFAPLVEYGCHSHLKFFLCSLYAPMCTEQ-V
STPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCSKLPNKNDPnyLCME
APNNGTDEAP-rsssilppifrpqrpnsghemypkdpkgrsscensgkfh
hveksascapl
>gi|310115|gb|AAA41172.1|_42:167   (L02530) Drosophila polarity gene (frizzled) homologue [Rattus norvegicus]
mrarsalprsalprlllpllllpaagpaqfhgekgisipdhGFCQPISIP
LCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSM
YAPVCTV--LEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPR
HGAEqICVGQNHSEDGTPA-llttappsglqpgaggtpggpggggappry
atlehpfhcprvlkvpsyls
>gi|4585279|gb|AAD25358.1|AF117388_1_33:160   (AF117388) frizzled protein; fz4 [Danio rerio]
mfaagvglslgllcfagfcsaissidpdrpgeGRCQEIAIPLCKDIGYNL
TVMPNLMGHEDQNEAAIKLHEFAPLIEFGCHSHLKFFLCSLYAPMCTEQ-
VSTPIPACRVMCEQARQKCSPIMEQFNFHWPESLDCSRLPNKNDPnyLCM
EAPNNGTDEPP-kgshtqspdsrpprpgnsqelpikervgkttcsnpgkf
hyvqksescapk
>gi|6649948|gb|AAF21644.1|AF039411_1_33:160   (AF039411) frizzled homolog [Danio rerio]
mfaagvglslgllcfagfcsaissidpdrpgeGRCQEIAIPLCKDIGYNL
TVMPNLMGHEDQNEAAIKLHEFAPLIEFGCHSHLKFFLCSLYAPMCTEQ-
VSTPIPACRVMCEQARQKCSPIMEQFNFHWPESLDCSRLPNKNDPnyLCM
EAPNNGTDEPP-kgshtqspdsrpprpgnsqelpikervgkttcsnpgkf
hyvqksescapk
>gi|4503825|ref|NP_003496.1|_114:229   frizzled 1; Wnt receptor
gi|7451366|pir||JE0337 Frizzled-1 protein - human
gi|3927883|dbj|BAA34666.1| (AB017363) frizzled-1 [Homo sapiens]
aplllgvraqaagqgpgqgpgpgqqpppppqqqqsgqqyngergisvpdh
GYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSA
ELKFFLCSMYAPVCTV--LEQALPPCRSLCERARQGCEALMNKFGFQWPD
TLKCEKFPVHGAGeLCVG-----------qntsdkgtptpsllpefwtsn
pqhgggghrggfpggagasergkfscpra
>gi|5305407|gb|AAD41636.1|AF072872_1_115:230   (AF072872) frizzled 1 [Homo sapiens]
plllgvraqaagqgpgqgpgpgqqppppppqqqqsgqqyngergisvpdh
GYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSA
ELKFFLCSMYAPVCTV--LEQALPPCRSLCERARQGCEALMNKFGFQWPD
TLKCEKFPVHGAGeLCVG-----------qntsdkgtptpsllpefwtsn
pqhgggghrggfpggagasergkfscpra
>gi|4506895|ref|NP_003005.1|_24:147   secreted frizzled-related  protein 4
gi|2920804|gb|AAC04617.1| (AF026692) frpHE [Homo sapiens]
mflsilvalclwlhlalgvrgap--CEAVRIPMCRHMPWNITRMPNHLHH
STQENAILAIEQYEELVDVNCSAVLRFFFCAMYAPICTLEFLHDPIKPCK
SVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLP-
-edvkwiditpdmmvqerpldvdckrlspdrckckkvkptlatylsknys
y
>gi|4503835|ref|NP_003499.1|_39:164   frizzled 9
gi|1906598|gb|AAC51174.1| (U82169) frizzled homolog [Homo sapiens]
mavaplrgalllwqllaaggaaleigrfdpergrgaap--CQAVEIPMCR
GIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAP
MCTDQ-VSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRND
PhaLCMEAPENATAGPA-ephkglgmlpvaprparppgdlgpgaggsgtc
enpekfqyveksrscapr
>gi|6863203|gb|AAC12873.2|_109:224   (AF054623) Frizzled-1 [Mus musculus]
wlleaplllgvraqaagqvsgpgqqappppqpqqsgqqyngergisipdh
GYCQPISIPLCTDMAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSA
ELKFFLCSMYAPVCTV--LEQALPPCRSLCERARQGCEALMNKFGFQWPD
TLKCEKFPVHGAGeLCVG-----------qntsdkgtptpsllpefwtsn
gqhggggyrggypggagtvergkfscpra
>gi|2655274|gb|AAB87968.1|_68:192   (AF031830) 7-transmembrane protein frizzled-1 [Gallus gallus]
grraggdrcprrppalplllllwaaalpaggqpaaqpaalsergisipdh
GYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSA
ELKFFLCSMYAPVCTV--LEQALPPCRSLCERARQGCEALMNKFGFQWPD
TLRCEKFPVHGAGeLCVGQNASERGTP--tpalrpeswtsnphrgggagg
sgpgeargrfscpralkvpsylnyrflge
>gi|7672423|gb|AAF66480.1|AF140346_1_24:147   (AF140346) frizzled related protein [Rattus norvegicus]
mllsilvalclwlrlalgvrgap--CEAVRIPMCRHMPWNITRMPNHLHH
STQENAILAIGQYEELVDVNCSSVLSFFLCAMYAPICTLEFLHDPIKPCK
SVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLP-
-edvkwiditpdmmvqersfdadckhlspdrckckkvkptlatylsknys
y
>gi|6005762|ref|NP_009128.1|_32:152   frizzled (Drosophila) homolog 10
gi|7512443|pir||JC7086 FZD10 protein - human
gi|5834488|dbj|BAA84093.1| (AB027464) Frizzled-10 [Homo sapiens]
mqrpgprlwlvlqvmgscaaissmdmerpgdGKCQPIEIPMCKDIGYNMT
RMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQ-V
STPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPnyLCME
APN--------ngsdeptrgsglfpplfrpqrphsaqehplkdggpgrgg
cdnpgkfhhve
>gi|7110524|gb|AAF36979.1|AF231711_1_49:164   (AF231711) 7-transmembrane receptor frizzled-1 [Xenopus laevis]
mkhshllqrcsaqlctrgsslilslllsvclsvegqyngekgisipdhGY
CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPEL
KFFLCSIYAPVCTV--LEQALPPCRSLCDRARQGCEALMNKFGFQWPESL
RCEKFPINGAGeLCVG-----------qnttesgtptpavpetwtsnsrt
yyrdkfmcpralkvpayvnyhflgekd
>gi|6273776|gb|AAF06359.1|AF139165_1_36:160   (AF139165) frizzled-2 [Xenopus laevis]
mqgvtrasilliiyhlftlslgqlhgekgisvpehGFCQPISIPLCTDIA
YNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSSELRFFLCSMYAPVCT
V--LEQAIPPCRSICERARHGCEALMNKFGFQWPERLRCENFPRHGAEqI
CVGQNHSEDGGP--tllttspphhgtpgppiyatldhpfhcprvlkvpsy
lnyrflgekdcaap
>gi|7340122|gb|AAF61095.1|AF224315_1_4:129   (AF224315) Frizzled-2 [Gallus gallus]
pdhGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQ
CSLELKFFLCSMYAPVCTV--LEQAIPPCRSICERARQGCEALMNKFGFQ
WPERLRCENFPRHGAEqICVGQNHSEDGGSS-aalltsaappaahgtpga
pryatpdrpfhcpralkvpgylnykflgekdc
>gi|1854030|gb|AAC60114.1|_29:152   (U78598) Frzb precursor [Xenopus laevis]
msptrkldsflllvipglvllllpnaycASCEPVRIPMCKSMPWNMTKMP
NHLHHSTQANAILAIEQFEGLLTTECSQDLLFFLCAMYAPICTIDFQHEP
IKPCKSVCERARAGCEPILIKYRHTWPESLACEELPVYDRGVCISPEAIV
TV----eqgtdsmpdfpmdsnngncgstagehckckpmkasqktylknny
nyvira
>gi|1688099|gb|AAC60113.1|_29:152   (U68059) frezzled [Xenopus laevis]
msrtrkvdsllllaipglallllpnaycASCEPVRIPMCKSMPWNMTKMP
NHLHHSTQANAILAIEQFEGLLTTECSQDLLFFLCAMYAPICTIDFQHEP
IKPCKSVCERARAGCEPILIKYRHTWPESLACEELPVYDRGVCISPEAIV
TV----eqgtdsmpdfsmdsnngncgsgrehckckpmkatqktylknnyn
yvirak
>gi|4689161|gb|AAD27789.1|AF088850_1_40:164   (AF088850) frizzled-9 [Mus musculus]
mavppllrgalllwqllatggaaleigrfdpergrgpap--CQAMEIPMC
RGIGYNLTRMPNLLGHTSQGEAAAQLAEFSPLVQYGCHSHLRFFLCSLYA
PMCTDQ-VSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRN
DPhaLCMEAPENATAGP--tephkglgmlpvaprparppgdsapgpgsgg
tcdnpekfqyveksrscap
>gi|6912384|ref|NP_036325.1|_43:171   frizzled (Drosophila) homolog 4
gi|7522622|pir||JC7127 frizzled protein 4 - human
gi|6277266|dbj|BAA86286.1| (AB032417) WNT receptor Frizzled-4 [Homo sapiens]
mawrgagpsvpgapggvglslglllqlllllgpargfgdeeeRRCDPIRI
SMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCS
VYVPMCTEK-INIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFP
PQNDHnhMCMEGPGDEEVPLPHktpiqpgeechsvgtnsdqyiwvkrsln
cvlkcgydaglysrsakeftdi
>gi|6007775|gb|AAF01036.1|AF183910_1_44:172   (AF183910) frizzled receptor 4 [Rattus norvegicus]
mawqgtgpsvrgmpggvrlrlgllllqllllqrpalgfgdeeeRRCDPIR
IAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLC
SVYVPMCTEK-INIPIGPCGGMCLSVKRRCEPVLKEFGFAWPDSLNCSKF
PPQNDHnhMCMEGPGDEEVPLPHktpiqpgeechsvgtnsdqyiwvkrsl
ncvlkcgydaglysrsakeftdi
>gi|6572469|emb|CAB63117.1|_31:154   (AJ251750) frizzled 4 protein [Xenopus laevis]
mgarsltllyllcclvvgliagfgeeeers--CDPIRITMCQNLGYNVTK
MPNLVGHELQADAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEK-IN
IPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHnhMCMEG
PGDDEVP---ahsktpvlpgedcnsfgpnsdqytwvkrsmncvlkcgyds
glynrlskef
>gi|7340124|gb|AAF61096.1|AF224316_1_31:156   (AF224316) Frizzled-4 [Gallus gallus]
merrggggrmlalllagllggargfgdeeeRRCDAIRIAMCQNLGYNVTK
MPNLVGHELQADAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEK-IN
IPIGPCGGMCLSVKRRCEPVLKEFGFAWPDSLNCSKFPPQNDHnhMCMEG
PGDEEVP---lhsktslqpgeechsmgsnsdqyiwvkrnldcvlkcgyda
glysrsakef
>gi|6679881|ref|NP_032081.1|_43:171   frizzled homolog 4 (Drosophila)
gi|1151254|gb|AAC52430.1| (U43317) transmembrane receptor [Mus musculus]
mawpgtgpssrgapggvglrlglllqfllllrptlgfgdeeeRRCDPIRI
AMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCS
VYVPMCTEK-INIPIGPCGGMCLSVKRRCEPVLREFGFAWPDTLNCSKFP
PQNDHnhMCMEGPGDEEVPLPHktpiqpgeechsvgsnsdqyiwvkrsln
cvlkcgydaglysrsakeftdi
>gi|7672425|gb|AAF66481.1|_24:147   (AF140347) frizzled related protein [Rattus norvegicus]
mllsilvalclwlrlalgvrgap--CEAVRIPMCRHMPWNITRMPNHLHH
STQENAILAIEQYEELVDVNCSSVLSFFLCAMYAPICTLEFLHDPIKPCK
SVSQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLP-
-edvkwiditpdmmvqersfdadckhlspdrckckkvkptlatylsknys
y
>gi|5042380|gb|AAB87503.2|_2:121   (AF033585) frizzled-9 protein [Mus musculus]
e-------IPMCRGIGYNLTRMPNLLGHTPQGEAAAQLAEFSPLVQYGCH
SHLRFFLCSLYAPMCTDQ-VSTPIPACRPMCEQARLRCAPIMEQFNFGWP
DSLDCARLPTRNDPhaLCMEAPENATAGP--tephkglgmlpvaprparp
pgdsapgpgsggtcdnpekfqyveksrscap
>gi|348411|pir||A45054_109:223   probable intercellular signal transducer or transmitter Fz-1 - rat
wlleaplllgvraqpagqvsgpgqqrppppqpqqggqqyngergisipdh
GYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSA
ELKFFLCSMYAPVCTV--LEQALPPCRSLCERAQ-GCEALMNKFGFQWPD
TLKCEKFPVHGRGeLCVG-----------qntsdkgtptpsllpefwtsn
pqhggggyrggypggagpvergkfscpra
>gi|310117|gb|AAA41173.1|_109:223   (L02529) Drosophila polarity gene  (frizzled) homologue [Rattus norvegicus]
wlleaplllgvraqpagqvsgpgqqrppppqpqqggqqyngergisipdh
GYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSA
ELKFFLCSMYAPVCTV--LEQALPPCRSLCERAQ-GCEALMNKFGFQWPD
TLKCEKFPVHGAGeLCVG-----------qntsdkgtptpsllpefwtsn
pqhggggyrggypggagpvergkfscpra
>gi|882059|gb|AAB38383.1|_57:171   (L43163) tissue polarity protein [Drosophila virilis]
srkmllqplllllmpallqsatidtvdassyyrsdltgssassldgfphh
NRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSA
DLQLFLCSLYVPVCTI--LERPIPPCRSLCESAR-VCETLMKTYNFNWPE
NLECSKFPVHGGEdLCVA-----------enttassstpaptrsapkvtt
rkhqisvdsphrnigfvcpvqlktplgmg
>gi|7294400|gb|AAF49746.1|_51:165   (AE003535) CG3646 gene product [Drosophila melanogaster]
mwrqilfilptliqgvqrydqspldaspyyrsggglmassgteldglphh
NRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSD
DLQLFLCSLYVPVCTI--LERPIPPCRSLCESAR-VCEKLMKTYNFNWPE
NLECSKFPVHGGEdLCVA-----------enttssastaatptrsvakvt
trkhqtgvesphrnigfvcpvqlktplgm
>gi|7983|emb|CAA38459.1|_51:165   (X54647) frizzled [Drosophila melanogaster]
mwrqilfilptliqgvqrydqspldaspyyrsggglmassgteldglphh
NRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSD
DLQLFLCSLYVPVCTI--LERPIPPCRSLCESAR-VCEKLMKTYNFNWPE
NLECSKFPVHGGEdLCVA-----------enttssastaatptrsvakvt
trkhqtgverphrnigfvcpvqlktplgm
>gi|103213|pir||S15709_51:165   hypothetical protein - fruit fly (Drosophila melanogaster)
gi|804980|emb|CAA38461.1| (X54648) frizzled (clone BE2) [Drosophila melanogaster]
mwrqilfilptliqgvqrydqspldaspyyrsggglmassgteldglphh
NRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSD
DLQLFLCSLYVPVCTI--LERPIPPCRSLCESAR-VCEKLMKTYNFNWPE
NLECSKFPVHGGEdLCVA-----------enttssastaatptrsvakvt
trkhqtgvesphrnigfvcpvqlktplgm
>gi|120529|sp|P18537|FRIZ_DROME_51:165   FRIZZLED PROTEIN PRECURSOR
gi|84965|pir||S03540 gene frizzled protein precursor - fruit fly (Drosophila melanogaster)
gi|103211|pir||S15708 hypothetical protein - fruit fly (Drosophila melanogaster)
gi|7981|emb|CAA38458.1| (X54646) frizzled [Drosophila melanogaster]
gi|804979|emb|CAA38460.1| (X54648) frizzled (clone AC2) [Drosophila melanogaster]
gi|226291|prf||1505374A Fz protein [Drosophila melanogaster]
mwrqilfilptliqgvqrydqspldaspyyrsggglmassgteldglphh
NRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSD
DLQLFLCSLYVPVCTI--LERPIPPCRSLCESAR-VCEKLMKTYNFNWPE
NLECSKFPVHGGEdLCVA-----------enttssastaatptrsvakvt
trkhqtgvesphrnigfvcpvqlktplgm
>gi|7511690|pir||T37325_23:146   wingless protein receptor Cfz2 - Caenorhabditis elegans
gi|5931530|dbj|BAA84678.1| (AB026113) Cfz2 [Caenorhabditis elegans]
mllrisvlflllgscgalfgkrQKCEQITIPLCKGIGYNMTSFPNSYGHE
KQEEAGLEVHQFYPLVEVGCFQHLKFFLCTMYTPICQEN-YDKPILPCME
LCVEARSKCSPIMAKYGFRWPETLSCEALPKMSDQmstgnICAAPPD---
-----tpkkqhkghhhknqnqnqnqnhnyspdgpevgiskidneviagps
ecqct
>gi|8400732|ref|NP_003003.2|_55:179   secreted frizzled-related protein 1
gi|2213819|gb|AAB61576.1| (AF001900) secreted frizzled-related protein [Homo sapiens]
gi|3033551|gb|AAC12877.1| (AF056087) secreted frizzled related protein [Homo sapiens]
rseggrrgalgvllalgaallavgsaseydyvsfqsdigpyqsgrfytkp
PQCVDIpaDLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNC
HAGTQVFLCSLFAPVC----LDRPIYPCRWLCEAVRDSCEPVMQFFGFYW
PEMLKCDKFPEGDVCIAMTPPNATEASKP-qgttvcppcdnelkseaiie
hlcasefalrmkikevkkengdkkivpkkk
>gi|2337937|gb|AAB67062.1|_50:174   (U85945) FrzA [Bos taurus]
mgggrwaaagallalaagllaagsaseydyvsfqsdigayqsgrfytkpP
QCVDIpaDLRLCHNVGYKRMVLPNLLEHETMAEVKQQASSWVPLLNKNCH
IGTQVFLCSLFAPVC----LDRPIYPCRWLCEAVRDSCEPVMQFFGFYWP
EMLKCDKFPEGDVCIAMTPPNATEASKP-qgttvcppcdnelkseaiieh
lcasefalrmkikevkkengdkkivpkkk
>gi|6636325|gb|AAF20143.1|AF207665_1_1:113   (AF207665) secreted frizzled-related protein [Gallus gallus]
---------------WNMTKMPNHLHHSTQANAVLAMEQFEGLLGTNCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARAGCEPVLIRYRHAWPE
SLACDELPLYDRGVCISPEAIVTAEGADfpmdsnngncggtgierckckp
ikatqktyvrnnynyvirakvkevktkc
>gi|2415417|gb|AAB70793.1|_56:180   (AF017987) secreted apoptosis related protein 2 [Homo sapiens]
seggrrgaalgvllalgaallavgsaseydyvsfqsdigpyqsgrfytkp
PQCVDIpaDLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNC
HAGTQVFLCSLFAPVC----LDRPIYPCRWLCEAVRDSCEPVMQFFGFYW
PEMLKCDKFPEGDVCIAMTPPNPTEASKP-qgttvcppcdnelkseaiie
hlcasefalrmkikevkkengdkkivpkkk
>gi|7305481|ref|NP_038862.1|_56:180   secreted frizzled-related sequence protein 1
gi|1946341|gb|AAC53145.1| (U88566) secreted frizzled related protein sFRP-1 [Mus musculus]
sargrggaasgvllalaaallaagsaseydyvsfqsdigsyqsgrfytkp
PQCVDIpvDLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNC
HMGTQVFLCSLFAPVC----LDRPIYPCRWLCEAVRDSCEPVMQFFGFYW
PEMLKCDKFPEGDVCIAMTPPNTTEASKP-qgttvcppcdnelkseaiie
hlcasefalrmkikevkkengdkkivpkkk
>gi|7494607|pir||T42210_35:143   Frizzled-1 protein homolog - Caenorhabditis elegans
gi|7508290|pir||T25162 hypothetical protein T23D8.1 - Caenorhabditis elegans
gi|2463674|gb|AAC47750.1| (AF013953) mom-5 gene product [Caenorhabditis elegans]
gi|3880075|emb|CAB03398.1| (Z81128) predicted using Genefinder~Similarity to Drosophila Tissue polarity protein (TR:Q24760)~cDNA EST yk471e5.5 comes from this gene [Caenorhabditis elegans]
mhrhililflfgclsadqrlsstsissmngfsttRKCEHITIPMCKNLDY
NQTVFPNLLGHTTQSEAGPAIAQFNPLIKVKCSEDIRLFLCTVYAPVCTV
--LEKPIQPCRELCLSAKNGCESLMKKFGFQWPDQLDCNKFPVTD-----
------------lcvgknssessnskkssndvtfgvstianevvlspkkc
phhmhttsgshf
>gi|7290800|gb|AAF46245.1|_44:170   (AE003439) CG4626 gene product [Drosophila melanogaster]
mkptcilcllvvillhprisksstsgnpsassssssppeipafRQCETIR
IEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLC
AAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKF
PRENNHetMCMEGPGELHQP---qqeqdlyglpgqgipgglggklpmdcs
glakshlyvrlprsgrcaplcea
>gi|6677895|ref|NP_033170.1|_38:153   stromal cell derived factor 5
gi|1946343|gb|AAC53146.1| (U88567) secreted frizzled related protein sFRP-2 [Mus musculus]
mprgpasllllvlashcclgsarglflfgqpdfsykrSNCKPIpaNLQLC
HGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFA
PVCLDD-LDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDN
D-LCI------------plassdhllpateeapkvceacktkneddndim
etlckndfalkikvkei
>gi|7512442|pir||JE0174_38:153   frizzled protein-2 - human
mlqgpgsllllflashcclgsarglflfgqpdfsykrSNCKPIpaNLQLC
HGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFA
PVCLDD-LDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDN
D-LCI------------plassdhllpateeapkvceacknkndddndim
etlckndfalkikvkei
>gi|4583388|gb|AAD25053.1|AF117759_1_48:161   (AF117759) secreted frizzled-related protein 5 [Mus musculus]
mwvawsartaalalllgalhgaptrgqeydyygwqaeplhgrsyskpPQC
LDIpaDLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSD
TQVFLCSLFAPVC----LDRPIYPCRSLCEAARAGCAPLMEAYGFPWPEM
LHCHKFPLDND-LCIA-----------vqfghlpatappvtkicaqceme
hsadglmeqmcssdfvvkmrikeikid
>gi|4583384|gb|AAD25051.1|AF117757_1_49:162   (AF117757) secreted frizzled-related protein 5 [Bos taurus]
mraaaggaraavlalllgalhgapargeeydyygwqteplhgrsyskpPQ
CLDIpaDLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHS
DTQVFLCSLFAPVC----LDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPE
MLHCHKFPLDND-LCIA-----------vqfghlpatappvtkicaqcem
ehsadglmeqmcssdfvvkmrikeikie
>gi|4506897|ref|NP_003006.1|_51:164   secreted frizzled-related protein 5
gi|2415419|gb|AAB70794.1| (AF017988) secreted apoptosis related protein 3 [Homo sapiens]
gi|4583386|gb|AAD25052.1|AF117758_1 (AF117758) secreted frizzled-related protein 5 [Homo sapiens]
mraaaaaggvrtaalalllgalhwaparceeydyygwqaeplhgrsyskp
PQCLDIpaDLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRC
HSDTQVFLCSLFAPVC----LDRPIYPCRSLCEAVRAGCAPLMEAYGFPW
PEMLHCHKFPLDND-LCIA-----------vqfghlpatappvtkicaqc
emehsadglmeqmcssdfvvkmrikeikie
>gi|7512441|pir||JE0175_51:164   frezzled protein-1b - human
mraaaaaggvrtaalalllgalhwaparceeyhyygwqaeplhgrsyskp
PQCLDIpaDLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRC
HSDTQVFLCSLFAPVC----LDRPIYPCRSLCEAVRAGCAPLMEAYGFPW
PEMLHCHKFPLDND-LCIA-----------vqfghlpatappvtkicaqc
emehsadglmeqmcssdfvvkmrikeikie
>gi|2415421|gb|AAB70795.1|_40:153   (AF017989) secreted apoptosis related protein 1 [Mus musculus]
mprgpasllllvlashcclgsarglflfgqpdfsykrtn--CKPIpaNLQ
LCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSL
FAPVCLDD-LDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQ
DND-LCI------------plassdhllpateeapkvceacktkneddnd
imetlckndfalkikvkei
>gi|1747302|dbj|BAA09053.1|_38:153   (D50462) SDF5 [Mus musculus]
mprgpasllllvlashcclgsarglflfgqpdfsykrSNCKPIpaNLQLC
HGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFA
PVCLDD-LDETIQPCHSLCMQVKDRCAPVMSAFGFPWPDMLECDRFPQDN
D-LCI------------plassdhllpateeapkvceacktkneddndim
etlckndfalkikvkei
>gi|1151180|gb|AAC52429.1|_28:136   (U43205) frizzled-3 [Mus musculus]
mavswivfdlwlltvflgqigghslfs--CEPITLRMCQDLPYNTTFMPN
LLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICME--YGRVT
LPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEP----------
-----yprlvdlnlvgdptegapvavqrdygfwcprelkidpdlgysflh
vrdcs
>gi|8393378|ref|NP_059108.1|_28:136   frizzled (Drosophila) homolog 3
gi|7649449|emb|CAB89114.1| (AJ272427) frizzled homolog 3 [Homo sapiens]
gi|7670052|dbj|BAA94968.1| (AB039723) WNT receptor frizzled-3 [Homo sapiens]
mamtwivfslwpltvfmghigghslfs--CEPITLRMCQDLPYNTTFMPN
LLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICME--YGRVT
LPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEP----------
-----yprlvdlnlageptegapvavqrdygfwcprelkidpdlgysflh
vrdcs
>gi|7381171|gb|AAF61420.1|_36:149   (AF136183) putative wnt inhibitor frzb2 [Xenopus laevis]
gi|7839501|gb|AAF70300.1|AF255340_1 (AF255340) Crescent [Xenopus laevis]
gi|7839591|gb|AAF70340.1|AF260729_1 (AF260729) crescent [Xenopus laevis]
mapqlcqslgkplivllcflacgsqsmyldffgssSRCMRIpkSMALCYD
IGYSEMRIPNLLEHETMAEAIQQSSSWLPLLARECHPDARIFLCSLFAPI
C----FDRYIFPCRSLCEAVRSSCAPIMACYGYPWPEILKCDKFPEDHG-
MCIS-----------titndtgstrrtvprascrdceleegstskeildt
fchndfvakvritkk
>gi|6746598|gb|AAF27642.1|AF218056_1_35:150   (AF218056) secreted frizzled-related protein-2 [Gallus gallus]
mprrlcallllasqclgstaglfpfgepdfsykrSNCKPIpaPMLLCRGI
EYQSMRLPNLLGHETVQEVLEQATTWIPLVQKQCHPDTRKFLCSLFAPVC
IDD-LDEIIQPCHSLCEEVKESCAPVMSAFGFPWPDMLDCSRFPKDND-L
CI------------plassdhilpvtreapkvcdacknkneddndimenl
ckndfalkikvkei
>gi|6578963|gb|AAF18154.1|AF209200_1_27:143   (AF209200) frizzled receptor [Hydra vulgaris]
mititinlmalslviscfdysesaanAECIPFahHFQICNKMPYNTTMFP
NLLEHRNPEEASLEVAQFKPLVKVGCSDDLEFFLCSVYAPVCLNH---GP
LPPCKPLCERARSGCISIMQKFGFIWPENIRCERYPDSTPNaLCID----
-------naetkkpeekvrvknktqssyndyrcktdqqkdakhynfmgkp
gcasecd
>gi|6539733|gb|AAF15998.1|_1:106   (AF153476) Frzb-1 [Gallus gallus]
----------------------NHLHHSTQANAVLAMEQFEGLLGTNCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARAGCEPVLIRYRHAWPE
SLACDELPLYDRGVCISPEAIVTAEGADfpmdsnngncrgtgierckckp
ikatqktylr
>gi|2226372|gb|AAB61752.1|_42:155   (AF006508) crescent [Gallus gallus]
mraastekasrrrgapwlpglllrlllwgcaggrasylrrsSSCTAIprS
MALCYDIGYSEMRIPNLLEHETMPEVIQQSSSWLPLLARECHPDARIFLC
SLFAPIC----LDRLIYPCRSLCEAVKRSCAPVMACYGYPWPEILNCNKF
PADHE-LCIA-----------avstdessssrrmprasckdceleeasta
reildnlcandftvkirilrk
>gi|2440219|emb|CAA04977.1|_26:135   (AJ001754) fz3 [Xenopus laevis]
maaylisfiwvsvilaqksmghslf-ACEPITLRMCQDLPYNSTFMPNLL
NHYDQQTAALAMEPFHPMVNLECSRDLRPFLCALYTPVCME--YGRMTLP
CRKLCQRAYNECFKLMEMFGVPWPEEMECSRFPDCDEP------------
---yprivdislsgepseetplavqrdygfwcprelkidpdlrssflgvr
dcs
>gi|4105677|gb|AAD02492.1|_52:165   (AF049908) frizzled-related protein; FrzA; Wnt-binding protein [Xenopus laevis]
ngengiwplllfwvtpgilsqvpqaseydyvsfqpdlgrqyqsgrfysrp
AQCLEIpqDMTLCHGVGYNKMVLPNLLDSETMAEVKYQASSWVPLLSKKC
HPSTQVFLCSLFAPLC----LDRPVYPCRRLCESVRDACEPVMQYFGFHW
PEMLRCEQYPTEED-VCIA-----------vhlpnatqaprsrktevcpq
cdseikadslyehmcasdfalkvsirevrk
>gi|7381173|gb|AAF61421.1|AF136184_1_25:137   (AF136184) putative wnt inhibitor frzb3 [Xenopus laevis]
mtgvflllcasmlaaaafdiglst-KCVPIpkEMAMCNDVGYSEMRLPNL
LGHTNMAEVVPKSAEWQNLLQTGCHPYARTFLCSLFAPVC----LDTFIQ
PCRSMCVAVRNSCAPVLACHGHSWPESLDCDRFPAGED-MCLD-------
----tlskeyqyaykelpkpscqgcplieeffshktvleafcdnnfavkv
klak
>gi|3089551|gb|AAC15063.1|_26:147   (AF059570) secreted Xwnt8 inhibitor sizzled [Xenopus laevis]
msgvflllcasmlactaafdiglst-KCVTIptEMAMCNDVGYSEMRLPN
LMGHTNMAEVVPKSAEWQNLLQTGCHPYARTFLCSLFAPVC----LDTFI
QPCRSMCVAVRDSCAPVLACHGHSWPESLDCDRFPAGED-MCLDTLSKEY
QYS--ykelpkpscqgcplieeffshktvleafcdnnfavkvklakkksa
sglye
>gi|1589780|gb|AAC47301.1|_26:149   (U63557) transmembrane receptor LIN-17 [Caenorhabditis elegans]
gi|7105632|gb|AAF36028.1| (AC024201) C. elegans transmembrane receptor LIN-17 (GB:U63557); contains similarity to Pfam family PF01392 (Fz domain), score=241.6, E=1.1e-68, N=1 [Caenorhabditis elegans]
mmhslgiillfiplatgsifdqavkGKCIPIDIELCKDLPYNYTYFPNTI
LHNDQHTLQTHTEHFKPLMKTKCHPHIHFFICSVFAPMCPIG-MPQAVTS
CKSVCEQVKADCFSILEEFGIGWPEPLNCAQFPDPPE-LCMKPTEDEITG
G--fsaprlptkgsssssskptgcpsdlvdvdphdpkshcafacqsnvmf
std
>gi|8394057|ref|NP_058565.1|_521:651   corin
gi|7513714|pir||JE0315 low-density lipoprotein receptor-related protein - mouse
gi|3869145|dbj|BAA34371.1| (AB013874) Low Density Lipoprotein Receptor Related Protein 4 [Mus musculus]
edckdgsdeencsdsqtpcpegeqgcfgsscvescagsslcdsdsslsnc
SQCEPITLELCMNLLYNHTHYPNYLGHRTQKEASISWEssLFPALVQTNC
YKYLMFFACTILVPKCDVN-TGQRIPPCRLLCEHSKERCESVLGIVGLQW
PEDTDCNQFPEESSDnqTCLLPNEDVEECSPShfkcrsgrcvlgsrrcdg
qadcdddsdeencgckeralwecpfnkqclkh
>gi|5729989|ref|NP_006578.1|_453:583   corin
gi|4884872|gb|AAD31850.1|AF133845_1 (AF133845) corin [Homo sapiens]
edckdgsdeencsviqtscqegdqrclynpcldscggsslcdpnnslnnc
SQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWEssLFPALVQTNC
YKYLMFFSCTILVPKCDVN-TGERIPPCRALCEHSKERCESVLGIVGLQW
PEDTDCSQFPEENSDnqTCLMPDEYVEECSPShfkcrsgqcvlasrrcdg
qadcdddsdeencgckerdlwecpsnkqclkh
>gi|7290081|gb|AAF45547.1|_39:166   (AE003418) fz3 gene product [Drosophila melanogaster]
myaasililhltwavatiaangaghngpvasgagpngl-QCQPIAVSACQ
GLGYNMTALPNLAGHTNQLEAELQIAKLVPLIESGCSRRARFLLCSSLFP
LCTPD-VPRPVAACKLLCETVRGECmENAPPELMELWPSFLNCDGLPQPE
KHeLCMQIPQEVAVPGGSpsgppttgspgvedhpqtyrfwksgasptsdl
agvlcpqnfsgspfnpee
>gi|7532831|gb|AAF63250.1|AF195242_1_39:166   (AF195242) FRIZZLED 3 [Drosophila melanogaster]
myaasililhltwavatiaangaghngpvasgagpngl-QCQPIAVSACQ
GLGYNMTALPNLAGHTNQLEAELQIAKLVPLIESGCSRRARFLLCSSLFP
LCTPD-VPRPVAACKLLCETVRGECmENAPPELMELWPSFLNCDGLPQPE
KHeLCMQIPQEVAVPGGSpsgppttgspgvedhpqtyrfwksgasptsdl
agvlcpqnfsgspfnpee
>gi|2415415|gb|AAB70792.1|_38:151   (AF017986) secreted apoptosis related protein 1 [Homo sapiens]
mlqgpgsllllflashcclgsarglflfgqpdfsykrSNCKPIpaNLQLC
HGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFA
PVCLDD-LDETIQPCHSRCVQVKDRCAPVMSAFP--WPDMLECDRFPQDN
D-LCI------------plassdhllpateeapkvceacknkndddndim
etlckndfalkikvkei
>gi|1151250|gb|AAC46993.1|_24:148   (U43316) transmembrane receptor [Caenorhabditis elegans]
gi|7331804|gb|AAF60492.1| (AC006736) C. elegans frizzled protein homolog precursor (GB:U43316); contains similarity to Pfam family PF01392 (Fz domain), score=182, E=9.2e-51, N-1 [Caenorhabditis elegans]
mgpfrgylgvtwllllfvigvdgQRCQKVDHEMCNDLPYNLTSFPNLVDE
ESWKDASESILTYKPLLSVVCSEQLKFFLCSVYFPMCNEK-LANPIGPCR
PLCLSVQEKCLPVLESFGFKWPDVIRCDKFPLENNRekMCMKGPNEQGA-
---iqderakfaakeseddgndrvediqrevdrlngkcpqdevflnrssk
cvp
>gi|7331805|gb|AAF60493.1|_24:148   (AC006736) C. elegans frizzled protein homolog precursor (GB:U43316); contains similarity to Pfam family PF01392 (Fz domain), score=182, E=9.2e-51, N-1 [Caenorhabditis elegans]
mgpfrgylgvtwllllfvigvdgQRCQKVDHEMCNDLPYNLTSFPNLVDE
ESWKDASESILTYKPLLSVVCSEQLKFFLCSVYFPMCNEK-LANPIGPCR
PLCLSVQEKCLPVLESFGFKWPDVIRCDKFPLENNRekMCMKGPNEQGA-
---iqderakfaakeseddgndrvediqrevdrlngkcpqdevflnrssk
cvp
>gi|4503831|ref|NP_003497.1|_24:146   frizzled 6
gi|7451363|pir||JE0164 frizzled-6 protein precursor - human
gi|3062803|dbj|BAA25686.1| (AB012911) Frizzled-6 [Homo sapiens]
gi|5305409|gb|AAD41637.1|AF072873_1 (AF072873) frizzled 6 [Homo sapiens]
memftflltciflpllrghslft--CEPITVPRCMKMAYNMTFFPNLMGH
YDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTCIE--QIHVVPPCR
KLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGP
-qkkteqvqrdigfwcprhlktsggqgykflgidqcappcpnmyfksdel
e
>gi|6679883|ref|NP_032082.1|_24:146   frizzled homolog 6 (Drosophila)
gi|1151256|gb|AAC52431.1| (U43319) transmembrane receptor [Mus musculus]
merspfllacillplvrghslft--CEPITVPRCMKMTYNMTFFPNLMGH
YDQGIAAVEMGHFLHLANLECSPNIEMFLCQAFIPTCTE--QIHVVLPCR
KLCEKIVSDCKKLMDTFGIRWPEELECNRLPHCDDTVPVTSHPHTELSGP
-qkksdqvprdigfwcpkhlrtsgdqgyrflgieqcappcpnmyfksdel
d
>gi|5931528|dbj|BAA84677.1|_39:166   (AB018565) Dfrizzled-3 [Drosophila melanogaster]
myaasililhltwavatiaangaghngpvasgagpngl-QCQPIAVSACQ
GLGYNMIALPNLAGHTNQLEAELQIAKLVPLIESGCSRRARFLLCSSLFP
LCTPD-VPRPVAACKLLCETVRGECmENAPPELMELWPSFLNCDGLPQPE
KHeLCMQIPQEVAVPGGSpsgppttgspgvedhpqtyrfwksgvsptsdl
agvlcpqnfsgspfnpee
>gi|7500013|pir||T31690_1:107   hypothetical protein F27E11.3 - Caenorhabditis elegans
gi|2291116|gb|AAB65257.1| (AF016413) similar to the FRIZZLED-like transmembrane receptors [Caenorhabditis elegans]
-----------------MTSFPNSYGHEKQEEAGLEVHQFYPLVEVGCFQ
HLKFFLCTMYTPICQEN-YDKPILPCMELCVEARSKCSPIMAKYGFRWPE
TLSCEALPKMSDQmstgnICAAPPD--------tpkkqhkghhhknqnqn
qnqnhnyspdgpevgiskidneviagpsecqct
>gi|7106481|dbj|BAA92184.1|_124:232   (AB031542) frizzled homolog [Ciona intestinalis]
gsgvaltflamllasdmlvptsavryadngpslsgrrkppisglsgrqgt
GVCEPIQVPMCIDIGYNFTDMSvSPSYIYDQKEAAQSVIQFGPLTKTKCA
EEMKLLVCSVYTPICIPG-YPGFLPPCRFICEAAKAGCEPILKKYDRTWP
NLFDCKQFPD-------------------sqgknppclhfnrsateepav
prtitkkgeskttpggpvasvthhpykpi
>gi|1917009|gb|AAB51299.1|_1:98   (U91904) Fritz [Mesocricetus auratus]
------------------------------ANXILXIXQFEGLLXTHCXG
DLLFFLCAMYAPICTXDFQREPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACEELPVYDRGVCISPEAIVTADGADfpmdsstghxrgasserckckp
vratrxtxfrnnynyvirakvkevkakc
>gi|2921088|gb|AAC04668.1|_44:168   (AF017637) carboxypeptidase Z [Rattus norvegicus]
mpttplllaalaalaalavaaypscspgpdpsgkcqrlasthsATCVDLH
LRTCADAAYNHTSFPTPLEHRSWEAVEASpeytlLGVLHFLLEGQCNPDL
RLLGCSVLAPRCQGGHTQR---PCRRVCEGLREACQPAFDAIDMAWPYFL
DCTQYFAPEEEGCYDPLEQLR-----geldveealpsglpptfirfahhs
yaqmvrvlkrtaarcsqvaktysigr
>gi|2921090|gb|AAC04669.1|_44:168   (AF017638) carboxypeptidase Z [Rattus norvegicus]
mpttplllaalaalaalavaaysscspgpdpsgkcqrlasthsATCVDLH
LRTCADAAYNHTSFPTPLEHRSWEAVEASpeytlLGVLHFLLEGQCNPDL
RLLGCSVLAPRCQGGHTQR---PCRRVCEGLREACQPAFDAIDMAWPYFL
DCTQYFAPEEEGCYDPLEQLR-----geldveealpsglpptfirfahhs
yaqmvrvlkrtaarcsqvaktysigr
>gi|4503025|ref|NP_003643.1|_30:156   carboxypeptidase Z precursor
gi|2160714|gb|AAB58911.1| (U83411) carboxypeptidase Z precursor [Homo sapiens]
mppppllllltvlvvaaarpgcefernpaATCVDLQLRTCSDAAYNHTTF
PNLLQHRSWEVVEASseyilLSVLHQLLEGQCNPDLRLLGCAVLAPRCEG
GWVRR---PCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCY
DPLEKLRGG---leadealpsglpptfirfshhsyaqmvrvlrrtasrca
hvartysigrsf
>gi|5729989|ref|NP_006578.1|_137:262   corin
gi|4884872|gb|AAD31850.1|AF133845_1 (AF133845) corin [Homo sapiens]
tdgeiqgsdviltntiynqstvvstahpdqhvpawttdaslpgdqshrnt
SACMNITHSQCQMLPYHATLTPLLSVVRNM-EMEKFLKFFTYLHRLSCYQ
HIMLFGCTLAFPECIIDGDDsHGLLPCRSFCEAAKEGCESVLGMVNYSWP
DFLRCSQFRNQTESsnvsrICFSPQQE-------ngkqllcgrgenflca
sgicipgklqcngyndcddwsdeahcncsenlfh
>gi|1167906|gb|AAC52903.1|_368:480   (U03715) alpha-1(XVIII) collagen [Mus musculus]
vpssdpsgqlsqvaalpgfpgtwvshvapssgtglsndsalagngsltst
SRCLPLppTLTLCSRLGIGHFWLPNHLHHTDSVEVEATVQAWGRFLHTNC
HPFLAWFFCLLLAPSCGPG-PPPPLPPCRQFCEALEDECWNYLA--GDRL
P--VVCASLPSQEDGYCV------------figpaaenvaeevgllqllg
dplpekisqiddphvgpayifgpdsnsgqv
>gi|841240|gb|AAA91635.1|_368:480   (U19600) alpha 1 type XVIII collagen [Mus cookii]
vpssdpsgqlsqvaalpgfpgtwvshvapssgtglsndsalagngsltst
SRCLPLppTLTLCSRLGIGHFWLPNHLHHTDSVEVEATVQAWGRFLHTNC
HPFLAWFFCLLLAPSCGPG-PPPPLPPCRQFCEALEDECWNYLA--GDRL
P--VVCASLPSQEDGYCV------------figpaaenvaeevgllqllg
dplpe
>gi|618430|gb|AAC52179.1|_368:480   (U11637) alpha-1 type XVIII collagen precursor [Mus musculus]
vpssdpsgqlsqvaalpgfpgtwvshvapssgtglsndsalagngsltst
SRCLPLppTLTLCSRLGIGHFWLPNHLHHTDSVEVEATVQAWGRFLHTNC
HPFLAWFFCLLLAPSCGPG-PPPPLPPCRQFCEALEDECWNYLA--GDRL
P--VVCASLPSQEDGYCV------------figpaaenvaeevgllqllg
dplpekisqiddphvgpayifgpdsnsgqv
>gi|7446033|pir||B56101_368:480   collagen alpha 1(XVIII) chain precursor, long splice form - mouse
vpssdpsgqlsqvaalpgfpgtwvshvapssgtglsndsalagngsltst
SRCLPLppTLTLCSRLGIGHFWLPNHLHHTDSVEVEATVQAWGRFLHTNC
HPFLAWFFCLLLAPSCGPG-PPPPLPPCRQFCEALEDECWNYLA--GDRL
P--VVCASLPSQEDGYCV------------figpaaenvaeevgllqllg
dplpekisqiddphvgpayifgpdsnsgqv
>gi|7304194|gb|AAF59230.1|_759:883   (AE003840) CG2105 gene product [Drosophila melanogaster]
ilinafallaiagglaayfnayptikfvnktiintihvedttsfgknpap
GTCLPIIVRFCQGpqIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRC
YELVSLFLCTLFVPKCGQ--SGATVPPCKTLCTETMRRCGFFFDVFGLSL
PEYLNCKLFKDFPSSeDCVGLDEVREV----mraathpkcdgfqcdqnrc
lpqeyvcdghldcmdqadeakcercgpdeiy
>gi|8394057|ref|NP_058565.1|_204:315   corin
gi|7513714|pir||JE0315 low-density lipoprotein receptor-related protein - mouse
gi|3869145|dbj|BAA34371.1| (AB013874) Low Density Lipoprotein Receptor Related Protein 4 [Mus musculus]
tdgearvpgvipvntvyyentgapslppsqstpawtprapspedqshrnt
STCMNITHSQCQILPYHSTLAPLLPIVKNM-DMEKFLKFFTYLHRLSCYQ
HILLFGCSLAFPECVVDGDDRhGLLPCRSFCEAAKEGCESVLGMVNSSWP
DSLRCSQFRDHTE----------------tnssvrkscfslqqehgkqsl
cgggesflctsglcvpkklqcngyndcdd
>gi|6226143|sp|P56726|SMO_MOUSE_72:210   SMOOTHENED HOMOLOG PRECURSOR (SMO)
gi|7513827|pir||JC5539 Smoothened protein precursor - mouse
llvllggpgrgaalsgnvtgpgphsasgssrrnvpvtsppppllshcgra
AHCEPLRYNVCLGsaLPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNaPR
CWAVIQPLLCAVYMPKCEND---RVELPSRTLCQATRGPCAIVERERG--
WPDFLRCtpDHFPEgcpnevqnikfNSSGQCEAPLVRTDNPKSWyedveg
cgiqcqnplfteaehqdmhsyiaafgavtglctlftlatfvadw
>gi|6981564|ref|NP_036939.1|_72:210   smoothened
gi|6226144|sp|P97698|SMO_RAT SMOOTHENED HOMOLOG PRECURSOR (SMO)
gi|1813878|gb|AAB41789.1| (U84402) smoothened [Rattus norvegicus]
llvllggrgrgaalsgnvtgpgprsaggsarrnapvtsppppllshcgra
AHCEPLRYNVCLGsaLPYGATTTLLAGDSDSQEEAHSKLVLWSGLRNaPR
CWAVIQPLLCAVYMPKCEND---RVELPSRTLCQATRGPCAIVERERG--
WPDFLRCtpDHFPEgcpnevqnikfNSSGQCEAPLVRTDNPKSWyedveg
cgiqcqnplfteaehqdmhsyiaafgavtglctlftlatfvadw
>gi|5032099|ref|NP_005622.1|_70:206   smoothened (Drosophila) homolog
gi|6226142|sp|Q99835|SMO_HUMAN SMOOTHENED HOMOLOG PRECURSOR (SMO)
gi|1813876|gb|AAB41788.1| (U84401) smoothened [Homo sapiens]
gi|4324955|gb|AAD17202.1| (AF114821) smoothened [Homo sapiens]
gi|6940763|gb|AAF31757.1| (AF120103) Gx protein [Homo sapiens]
llllgdpgrgaassgnatgpgprsaggsarrsaavtgpppplshcgraap
--CEPLRYNVCLGsvLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNaPR
CWAVIQPLLCAVYMPKCEND---RVELPSRTLCQATRGPCAIVERERG--
WPDFLRCtpDRFPEgctnevqnikfNSSGQCEVPLVRTDNPKSWyedveg
cgiqcqnplfteaehqdmhsyiaafgavtglctlftlatfvadw
>gi|7839499|gb|AAF70299.1|AF255339_1_41:121   (AF255339) secreted frizzled-related protein 2 [Xenopus laevis]
mwhsgsryvvvvlvvllacdcmdsvralfpfgqpefsykrSNCKPIpaTL
VLCHDIEYPNMRLPNLLGHESMKEVLQQASSWIPLVQKQCHQDTKKFLCS
LFAPVCIDD-LDETIKPCRSLC----------------------------
--------------------
>gi|6226140|sp|O42224|SMO_CHICK_38:176   SMOOTHENED HOMOLOG PRECURSOR (SMO)
gi|2618975|gb|AAB84389.1| (AF019977) smoothened [Gallus gallus]
gpcwlwalalglalgprrcpaaplnasaappercrrpAACERLRFGSCLG
saLPYAHTSTLLAADSGSQEEAHGKLLLWSGLRNaPRCWDVIQPLLCAVY
MPKCEDG---QVELPSQTLCQATRAPCTIVERERG--WPDFLKCtpDRFP
EgcpnevqnikfNSSGQCEAPLVRTYNPKSWyedvegcgiqcqnplftet
ehremhvyiafssvtisctfftlatfvadwr
>gi|7290916|gb|AAF46357.1|_372:492   (AE003443) CG1632 gene product [Drosophila melanogaster]
rhfanmtvdvaslsikettglieepimsssplgghdettepvvtttpapp
RRCSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHR
EAYDFVCRLLQPPCdthGSDLQPTPGQICREYCESFMAGC-------GGR
LPqrfrQFFDCERFPESTGTqSCHQKPH--------cvsdmqsnvqsprl
cdgyadcpdlsderscafcspnalycgrgracvprk
>gi|7297269|gb|AAF52532.1|_312:435   (AE003618) CG6739 gene product [Drosophila melanogaster]
llkellhkpqatpagneptltrvsptlppplsasgrpteamalttpsttn
SGCQSTMLPMCQGvLDYDLTFNREGAAPRD----AVSMAAYDSLIRANCS
VRAAEFICGALEPECRPLHIGQ-LPPCRRICKAILEAC-SIPIYNSDVLG
ELFDCNLYPDAHEShKCEDPTRRRDYCYGNefqchdgscipqnwqcdkik
dcqggededeqclvcepdefrcrsnekclv
>gi|7511863|pir||T13484_19:111   frizzled protein homolog - fruit fly (Drosophila melanogaster)
gi|3645951|emb|CAA20896.1| (AL031583) /prediction=(method:""genefinder"", version:""084"", score:""60.60"")~/match=(desc:""DFZ2"", species:""Drosophila melanogaster (Fruit fly)"", ranges:(query:5735..5932, target:SPTREMBL::Q94916:82..147, score:""117.00""), (query:6239..6445, ta>
mdkktkercvegldylip--------------------------------
----IAKLVPLIESGCSRRARFLLCSSLFPLCTPD-VPRPVAACKLLCET
VRGECmENAPPELMELWPSFLNCDGLPQPEKHeLCMQIPQEVAVPGGSps
gppttgspgvedhpqtyrfwksgasptsdlagvlcpqnfsgspfnpee
>gi|5732916|gb|AAD49337.1|AF167308_1_1:45   (AF167308) secreted frizzled-related protein sFRP-1 [Rattus norvegicus]
--------------------------------------------------
--------------------------------VRDSCEPVMQFFGFYWPE
MLKCDKFPEGDVCIAMTPPNATEASKP-qgttvcppcdnelkseaiiehl
casefalrmkikevkkengdkkivpkkk

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Date: Thu, 6 Jul 2000 00:42:24 -0700
From: UCSC Computational Biology <farmer@cse.ucsc.edu>
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Subject: T0106(database hits)
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The following are search results using the SAM-T99 method
for a sequence query against a database. If there
are no hits associated with this output, then your
score cutoff was too conservative.

Citation:  
  K. Karplus, C. Barrett, and R. Hughey,
  Hidden Markov Models for Detecting Remote Protein Homologies,
  Bioinformatics, 1998, vol. 14, no. 10, pp. 846-856. 
  http://www.cse.ucsc.edu/resesarch/compbio/HMM-apps
--------------------------------------------------------

For questions or problems, please see the SAM-T99 FAQ at

http://www.cse.ucsc.edu/research/compbio/HMM-apps/sam-t99-faq.html

or email us at sam-info@cse.ucsc.edu

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Content-Disposition: attachment; filename="t99-results-962825242.t99dbhits.txt"

The E-value is an estimate of approximately  how many
sequences would score this well by chance in the database
searched.  For SAM-T99, E-values less than about 0.01 are
roughly equivalent, as sequences that score that well have
most likely already been included in the SAM-T99 multiple
alignment.

Database: PDB (updated Mon Jul  3 11:52:44 2000)
Score method: average

Summary of Database Hits:
                  Average               Target               Template     
SeqID       Reverse     EValue    Reverse     EValue    Reverse     EValue  SeqLabel
1qatB        -11.33     0.2727  ---------  ---------     -11.33       0.27  

1d2rB         -6.33       40.4  ---------  ---------      -6.33         40  

1eaiC         -6.25      43.76      -6.25         44  ---------  ---------  : mol:protein length:61     Chymotrypsin/Elastase Isoinhibitor 1

1eaiD         -6.25      43.76      -6.25         44  ---------  ---------  : mol:protein length:61     Chymotrypsin/Elastase Isoinhibitor 1

1auj          -6.16      47.87      -6.16         48  ---------  ---------  :  mol:protein length:223     Trypsin              

1az8          -6.16      47.87      -6.16         48  ---------  ---------  :  mol:protein length:223     Trypsin              

1bju          -6.16      47.87      -6.16         48  ---------  ---------  :  mol:protein length:223     Beta-Trypsin         

1bjv          -6.16      47.87      -6.16         48  ---------  ---------  :  mol:protein length:223     Beta-Trypsin         

1ce5A         -6.16      47.87      -6.16         48  ---------  ---------  : mol:protein length:223     Trypsin               

1cu7A         -6.16      47.87      -6.16         48  ---------  ---------  : mol:protein length:223     Trypsin               

1cu8A         -6.16      47.87      -6.16         48  ---------  ---------  : mol:protein length:223     Trypsin               

1cu9A         -6.16      47.87      -6.16         48  ---------  ---------  : mol:protein length:223     Trypsin               

1d6rA         -6.16      47.87      -6.16         48  ---------  ---------  : mol:protein length:223     Trypsinogen           

1f2sE         -6.16      47.87      -6.16         48  ---------  ---------  : mol:protein length:223     Trypsin               

1gbt          -6.16      47.87      -6.16         48  ---------  ---------  :  mol:protein length:223     Beta-Trypsin (E.C. 3.4.21.4) Guanidinobenzoy

1jrsA         -6.16      47.87      -6.16         48  ---------  ---------  : mol:protein length:223     Trypsin               

1jrtA         -6.16      47.87      -6.16         48  ---------  ---------  : mol:protein length:223     Trypsin               

1max          -6.16      47.87      -6.16         48  ---------  ---------  :  mol:protein length:223     Beta-Trypsin         

1may          -6.16      47.87      -6.16         48  ---------  ---------  :  mol:protein length:223     Beta-Trypsin         

1mts          -6.16      47.87      -6.16         48  ---------  ---------  :  mol:protein length:223     Trypsin              


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>T0106
aacepvr-------------------------------------------
---------------------------------------IPLCKSLPWEM
TKMPNHLHHSTQANAILAMEQFEG--------------------------
---------------------------------------LLGTHCSPDLL
FFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPESLA
CDEL----------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------pvydrgvcispeaivtadgad
>1qatB  mol:protein length:622     Phospholipase C Delta-1
mdqrqklqhwihsclrkadknkdnkmnfkelkdflkelniqvddgyarki
frecdhsqtdsledeeietfyKMLTQRAEIDRAFEEAAGSAETLSVERLV
TFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADG
NAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALC
KGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYP
VILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGK
ILLKGKKLGGLLpaggengseatdvsdeveaaemedeavrsqvqhkpked
klKLVPELSDMIIYCKSVHFGGFSSpgtsGQAFYEMASFSESRALRLLQE
SGNGFVRHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGP
EMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWRPERLRVR
IISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPRW
DMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVH
LLSKNGDQHPSATLFVKISIQD


>T0106
aacepvriplckslpwemtkmp----------------NHL---------
--------------HHSTQ-------------------------------
--------------------ANAILAMEQFEGLLGTHCSPDLLFFlcaMY
APICTIDFQH-------------EPIKPCKSVCERARQGCEPILIKYRHS
WPESLACDELPVYDRGVC----ISPEAIVTADgaD---------------
--------------------------------------------------
--------------------------------------------------
---
>1d2rB  mol:protein length:326     Tryptophanyl tRNA Synthetase
MKTIFSGIQPSGVITIGNYIGALRQFVELQHEYNCYFCIVDQHAITVWQD
PHELRQNIRRLAALYLAVGIDPTQATLFIQSEVPAHAQAAWMLQCIVYIG
ELERMTQFKEKSAGAAAAAAGLLTYPPLMAADILLYNTDIVPVGEDQKQH
IELTRDLAERFNKRYGELFTIPEARIPKVGARIMSLVDPTKKMSKSDPNP
KAYITLLDDAKTIEKKIKSAVTDSEGTIRYDKEAKPGISNLLNIYSTLSG
QSIEELERQYEGKGYGVFKADLAQVVIETLRPIQERYHHWMESEELDRVL
DEGAEKANRVASEMVRKMEQAMGLGR


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1eaiC  mol:protein length:61     Chymotrypsin/Elastase Isoinhibitor 1
gqescgpnevwtectg----------------------------------
-----------------------------CEMKCGPDENTPCPLMCRRPS
CECSP---------------------------------------grgmrr
tndgkcipasqcp


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1eaiD  mol:protein length:61     Chymotrypsin/Elastase Isoinhibitor 1
gqescgpnevwtectg----------------------------------
-----------------------------CEMKCGPDENTPCPLMCRRPS
CECSP---------------------------------------grgmrr
tndgkcipasqcp


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1auj   mol:protein length:223     Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1az8   mol:protein length:223     Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1bju   mol:protein length:223     Beta-Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1bjv   mol:protein length:223     Beta-Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1ce5A  mol:protein length:223     Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1cu7A  mol:protein length:223     Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1cu8A  mol:protein length:223     Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1cu9A  mol:protein length:223     Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1d6rA  mol:protein length:223     Trypsinogen
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1f2sE  mol:protein length:223     Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1gbt   mol:protein length:223     Beta-Trypsin (E.C. 3.4.21.4) Guanidinobenzoy
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1jrsA  mol:protein length:223     Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1jrtA  mol:protein length:223     Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1max   mol:protein length:223     Beta-Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1may   mol:protein length:223     Beta-Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn


>T0106
AACEPVRIPLCKSLPWEMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSP
DLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE
SLACDELPVYDRGVCISPEAIVTADGAD
>1mts   mol:protein length:223     Trypsin
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrl
gedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislpts------------------------------------------
-------------------------------------CASAGTQClisgW
GNTKSSGTSYPDVLKCLKAPILSDSSC-------------ksaypgqits
nmfcagyleggkdscqgdsggpvvcsgklqgivswgsgcaqknkpgvytk
vcnyvswikqtiasn

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Content-type: text/plain; charset=us-ascii; name='t99-results-962825242.t99pairwise.casp.al'
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PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1qat_B
I 8 S 288
P 9 L 289
L 10 A 290
C 11 H 291
K 12 R 292
S 13 R 293
L 14 V 294
P 15 Y 295
W 16 Q 296
E 17 D 297
M 18 M 298
T 19 D 299
K 20 Q 300
M 21 P 301
P 22 L 302
N 23 S 303
H 24 H 304
L 25 Y 305
H 26 L 306
H 27 V 307
S 28 S 308
T 29 S 309
Q 30 S 310
A 31 H 311
N 32 N 312
A 33 T 313
I 34 Y 314
L 35 L 315
A 36 L 316
M 37 E 317
E 38 D 318
Q 39 Q 319
F 40 L 320
E 41 T 321
G 42 G 322
L 43 S 388
L 44 L 389
G 45 E 390
T 46 N 391
H 47 H 392
C 48 C 393
S 49 S 394
P 50 L 395
D 51 E 396
L 52 Q 397
L 53 Q 398
F 54 R 399
F 55 V 400
L 56 M 401
C 57 A 402
A 58 R 403
M 59 H 404
Y 60 L 405
A 61 R 406
P 62 A 407
I 63 I 408
C 64 L 409
T 65 G 410
I 66 P 411
D 67 I 412
F 68 L 413
Q 69 L 414
H 70 D 415
E 71 Q 416
P 72 P 417
I 73 L 418
K 74 D 419
P 75 G 420
C 76 V 421
K 77 T 422
S 78 T 423
V 79 S 424
C 80 L 425
E 81 P 426
R 82 S 427
A 83 P 428
R 84 E 429
Q 85 Q 430
G 86 L 431
C 87 K 432
E 88 G 433
P 89 K 434
I 90 I 435
L 91 L 436
I 92 L 437
K 93 K 438
Y 94 G 439
R 95 K 440
H 96 K 441
S 97 L 442
W 98 G 443
P 99 G 444
E 100 L 445
S 101 L _
L 102 K 487
A 103 L 488
C 104 V 489
D 105 P 490
E 106 E 491
L 107 L 492
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1d2r_B
N 23 G 17
H 24 N 18
L 25 Y 19
H 26 H 43
H 27 A 44
S 28 I 45
T 29 T 46
Q 30 V 47
A 31 I 99
N 32 G 100
A 33 E 101
I 34 L 102
L 35 E 103
A 36 R 104
M 37 M 105
E 38 T 106
Q 39 Q 107
F 40 F 108
E 41 K 109
G 42 E 110
L 43 K 111
L 44 S 112
G 45 A 113
T 46 G 114
H 47 A 115
C 48 A 116
S 49 A 117
P 50 A 118
D 51 A 119
L 52 A 120
L 53 G 121
F 54 L 122
F 55 L 123
M 59 T 124
Y 60 Y 125
A 61 P 126
P 62 P 127
I 63 L 128
C 64 M 129
T 65 A 130
I 66 A 131
D 67 D 132
F 68 I 133
Q 69 L 134
H 70 L 135
E 71 Q 149
P 72 H 150
I 73 I 151
K 74 E 152
P 75 L 153
C 76 T 154
K 77 R 155
S 78 D 156
V 79 L 157
C 80 A 158
E 81 E 159
R 82 R 160
A 83 F 161
R 84 N 162
Q 85 K 163
G 86 R 164
C 87 Y 165
E 88 G 166
P 89 E 167
I 90 L 168
L 91 F 169
I 92 T 170
K 93 I 171
Y 94 P 172
R 95 E 173
H 96 A 174
S 97 R 175
W 98 I 176
P 99 P 177
E 100 K 178
S 101 V 179
L 102 G 180
A 103 A 181
C 104 R 182
D 105 I 183
E 106 M 184
L 107 S 185
P 108 L 186
V 109 V 187
Y 110 D 188
D 111 P 189
R 112 T 190
G 113 K 191
V 114 K 192
C 115 M 193
I 116 P 198
S 117 N 199
P 118 P 200
E 119 K 201
A 120 A 202
I 121 Y 203
V 122 I 204
T 123 T 205
A 124 L 206
D 125 L 207
D 128 D 208
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1eai_C
C 64 C 17
T 65 E 18
I 66 M 19
D 67 K 20
F 68 C 21
Q 69 G 22
H 70 P 23
E 71 D 24
P 72 E 25
I 73 N 26
K 74 T 27
P 75 P 28
C 76 C 29
K 77 P 30
S 78 L 31
V 79 M 32
C 80 C 33
E 81 R 34
R 82 R 35
A 83 P 36
R 84 S 37
Q 85 C 38
G 86 E 39
C 87 C 40
E 88 S 41
P 89 P 42
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1eai_D
C 64 C 17
T 65 E 18
I 66 M 19
D 67 K 20
F 68 C 21
Q 69 G 22
H 70 P 23
E 71 D 24
P 72 E 25
I 73 N 26
K 74 T 27
P 75 P 28
C 76 C 29
K 77 P 30
S 78 L 31
V 79 M 32
C 80 C 33
E 81 R 34
R 82 R 35
A 83 P 36
R 84 S 37
Q 85 C 38
G 86 E 39
C 87 C 40
E 88 S 41
P 89 P 42
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1auj
C 80 C 128
E 81 A 129
R 82 S 130
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1az8
C 80 C 128
E 81 A 129
R 82 S 130
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1bju
C 80 C 128
E 81 A 129
R 82 S 131
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1bjv
C 80 C 128
E 81 A 129
R 82 S 130
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1ce5_A
C 80 C 128
E 81 A 129
R 82 S 130
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1cu7_A
C 80 C 109
E 81 A 110
R 82 S 111
A 83 A 112
R 84 G 113
Q 85 T 114
G 86 Q 115
C 87 C 116
E 88 W 121
P 89 G 122
I 90 N 123
L 91 T 124
I 92 K 125
K 93 S 126
Y 94 S 127
R 95 G 128
H 96 T 129
S 97 S 130
W 98 Y 131
P 99 P 132
E 100 D 133
S 101 V 134
L 102 L 135
A 103 K 136
C 104 C 137
D 105 L 138
E 106 K 139
L 107 A 140
P 108 P 141
V 109 I 142
Y 110 L 143
D 111 S 144
R 112 D 145
G 113 S 146
V 114 S 147
C 115 C 148
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1cu8_A
C 80 C 109
E 81 A 110
R 82 S 111
A 83 A 112
R 84 G 113
Q 85 T 114
G 86 Q 115
C 87 C 116
E 88 W 121
P 89 G 122
I 90 N 123
L 91 T 124
I 92 K 125
K 93 S 126
Y 94 S 127
R 95 G 128
H 96 T 129
S 97 S 130
W 98 Y 131
P 99 P 132
E 100 D 133
S 101 V 134
L 102 L 135
A 103 K 136
C 104 C 137
D 105 L 138
E 106 K 139
L 107 A 140
P 108 P 141
V 109 I 142
Y 110 L 143
D 111 S 144
R 112 D 145
G 113 S 146
V 114 S 147
C 115 C 148
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1cu9_A
C 80 C 109
E 81 A 110
R 82 S 111
A 83 A 112
R 84 G 113
Q 85 T 114
G 86 Q 115
C 87 C 116
E 88 W 121
P 89 G 122
I 90 N 123
L 91 T 124
I 92 K 125
K 93 S 126
Y 94 S 127
R 95 G 128
H 96 T 129
S 97 S 130
W 98 Y 131
P 99 P 132
E 100 D 133
S 101 V 134
L 102 L 135
A 103 K 136
C 104 C 137
D 105 L 138
E 106 K 139
L 107 A 140
P 108 P 141
V 109 I 142
Y 110 L 143
D 111 S 144
R 112 D 145
G 113 S 146
V 114 S 147
C 115 C 148
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1d6r_A
C 80 C 128
E 81 A 129
R 82 S 130
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1f2s_E
C 80 C 128
E 81 A 129
R 82 S 130
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1gbt
C 80 C 128
E 81 A 129
R 82 S 130
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1jrs_A
C 80 C 128
E 81 A 129
R 82 S 130
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1jrt_A
C 80 C 128
E 81 A 129
R 82 S 130
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1max
C 80 C 128
E 81 A 129
R 82 S 131
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1may
C 80 C 128
E 81 A 129
R 82 S 131
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END


PFRMAT AL
TARGET T0106
AUTHOR UCSC SAM-T99 Web Server
METHOD This pairwise alignment was produced using the SAM-T99 method
METHOD 
METHOD  ------------- Citations (SAM, SAM-T99, HMMs) -----------------
METHOD R. Hughey, A. Krogh, Hidden Markov models for sequence analysis:
METHOD   Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
METHOD K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting
METHOD   remote protein homologies, Bioinformatics 14(10):846-856, 1999.
METHOD A. Krogh et al., Hidden Markov models in computational biology:
METHOD   Applications to protein modeling, JMB 235:1501-1531, Feb 1994.
MODEL 1
PARENT 1mts
C 80 C 128
E 81 A 129
R 82 S 130
A 83 A 132
R 84 G 133
Q 85 T 134
G 86 Q 135
C 87 C 136
E 88 W 141
P 89 G 142
I 90 N 143
L 91 T 144
I 92 K 145
K 93 S 146
Y 94 S 147
R 95 G 148
H 96 T 149
S 97 S 150
W 98 Y 151
P 99 P 152
E 100 D 153
S 101 V 154
L 102 L 155
A 103 K 156
C 104 C 157
D 105 L 158
E 106 K 159
L 107 A 160
P 108 P 161
V 109 I 162
Y 110 L 163
D 111 S 164
R 112 D 165
G 113 S 166
V 114 S 167
C 115 C 168
TER
END

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Subject: T0106(target 99 secondary structure prediction)
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The following is the Target99 secondary structure prediction in the formats you requested.

Citation:  
  K. Karplus, C. Barrett, and R. Hughey,
  Hidden Markov Models for Detecting Remote Protein Homologies,
  Bioinformatics, 1998, vol. 14, no. 10, pp. 846-856. 
  http://www.cse.ucsc.edu/resesarch/compbio/HMM-apps
--------------------------------------------------------

For questions or problems, please see the SAM-T99 FAQ at

http://www.cse.ucsc.edu/research/compbio/HMM-apps/sam-t99-faq.html

or email us at sam-info@cse.ucsc.edu


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>T0106
LLLLEEEELELLLLLLLLLLLLLLLLLLLHHHHHHHHHHHHHHHHLLLHHHHHHHHHHHLLLLLLLLLLLLLLLLHHHHHHHHHHHHHHHHHHHLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL

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PFRMAT SS
TARGET T0106
AUTHOR UCSC Target99 server
METHOD This prediction was derived from the following methods
METHOD by averaging the corresponding probabilities: 
METHOD Method 0:
METHOD  TARGET T0106
METHOD  Using neural net overrep-2500-IDaa13-5-9-7-10-5-9-11-ehl2-seeded2-stride-trained.net
METHOD  This is a 4-layer network, with 
METHOD 	window	units
METHOD 	    5	    9
METHOD 	    7	   10
METHOD 	    5	    9
METHOD 	   11	    3 (1 EHL2 )
METHOD  The input amino acid frequencies were determined from
METHOD  alignment /projects/compbio/tmp/hmm-target99-beta-5901/target-align-5901.a2m
METHOD  with weighted counts, using EntropyWeight(1.4 bits/column, 10)
METHOD  The weighting was determined by the posterior distribution
METHOD  after regularizing with /projects/compbio/lib/recode3.20comp.
METHOD  Counts were regularized to probabilities using
METHOD  /projects/compbio/lib/recode3.20comp
METHOD  Total sequence weight for alignment was 26.7106
METHOD 
METHOD  CHAIN 1
METHOD Method 1:
METHOD  Prediction using SAM HMM nearest-neighbor
METHOD  sequence: T0106
METHOD  model_file: /projects/compbio/tmp/sam-nn-tmp.beta.8122/model.mod
METHOD  database_files: /projects/compbio/bin/scripts/hmm-target99-dir/pcc/data/overrep-2260.verify.mixed.seq /projects/compbio/bin/scripts/hmm-target99-dir/pcc/data/overrep-2260.verify.mixed.2d
METHOD  scoring_mode: local
METHOD  null_model: reverse
METHOD  scoring_algorithm: EM
METHOD  adjust_score: 2
METHOD  date: Thu Jul  6 00:44:36 2000
METHOD Method 2:
METHOD ###begin 0
METHOD 
METHOD  Protein secondary structure prediction by universal HMM
METHOD  HMM file: /projects/compbio/bin/scripts/hmm-target99-dir/pcc/scripts/gdac.test.initreest.38state.abb.isites.gd.updated.ghmm-128reest-1-128-105-0.07gd
METHOD  Alignment file: /projects/compbio/tmp/hmm-target99-beta-5901/target-align-5901.a2m
METHOD 
METHOD  guide seq name: T0106
METHOD ###end 0
MODEL 1
A C    0.641
A C    0.576
C C    0.533
E C    0.452
P E    0.398
V E    0.464
R E    0.439
I E    0.398
P C    0.389
L E    0.365
C C    0.391
K C    0.472
S C    0.515
L C    0.544
P C    0.601
W C    0.512
E C    0.525
M C    0.455
T C     0.44
K C    0.468
M C    0.625
P C    0.632
N C    0.599
H C     0.55
L C    0.583
H C    0.629
H C    0.487
S C     0.48
T C    0.484
Q H    0.665
A H     0.69
N H      0.7
A H    0.702
I H     0.69
L H    0.693
A H    0.676
M H    0.681
E H    0.665
Q H    0.653
F H    0.623
E H    0.586
G H    0.581
L H    0.554
L H    0.514
G H    0.456
T C     0.44
H C    0.508
C C    0.482
S H    0.449
P H    0.576
D H    0.591
L H     0.61
L H    0.607
F H    0.608
F H    0.594
L H    0.574
C H    0.532
A H    0.531
M H     0.45
Y C     0.41
A C    0.646
P C    0.637
I C    0.555
C C    0.556
T C    0.588
I C    0.604
D C    0.636
F C    0.607
Q C    0.628
H C    0.666
E C     0.66
P C    0.599
I C    0.592
K C    0.631
P C    0.474
C H    0.463
K H    0.538
S H    0.569
V H    0.611
C H     0.59
E H    0.629
R H    0.631
A H    0.614
R H    0.627
Q H    0.607
G H    0.582
C H    0.544
E H    0.537
P H    0.571
I H    0.588
L H    0.609
I H    0.592
K H    0.588
Y H    0.517
R C    0.646
H C    0.638
S C    0.614
W C    0.671
P C    0.583
E C    0.487
S C    0.413
L C    0.431
A C    0.462
C C    0.446
D C    0.512
E C     0.52
L C    0.674
P C    0.697
V C    0.678
Y C    0.713
D C    0.728
R C    0.704
G C    0.644
V C    0.455
C C    0.418
I C    0.458
S C    0.585
P C    0.632
E C    0.606
A C    0.653
I C    0.583
V C     0.53
T C    0.601
A C    0.711
D C     0.79
G C    0.845
A C    0.861
D C    0.842
END

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