; SAM: prettyalign v3.1b (February 24, 1999) compiled 04/18/00_11:44:15 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ------ Citations (HMMs, SAM) ------ ; A. Krogh et al., Hidden Markov models in computational biology: ; ------------- Citations (SAM, SAM-T99, HMMs) ----------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; -------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 gi|130096|sp|P16684|PHNF_ECOLI_6:173 ; 2 gi|7480730|pir||T35298_8:196 ; 3 gi|7140835|gb|AAF37157.1|AF047034_2_8:200 ; 4 gi|1857431|gb|AAB67744.1|_21:251 ; 5 gi|6226387|sp|O07792|Y586_MYCTU_4:226 ; 6 gi|6840861|gb|AAF28803.1|_8:211 ; 7 gi|1176201|sp|P45427|YHCK_ECOLI_25:249 ; 8 gi|4731015|gb|AAD28343.1|AF102509_1_9:223 ; 9 gi|462490|sp|P33233|LLDR_ECOLI_1:226 ; 10 gi|7473999|pir||B75340_12:223 ; 11 gi|5881926|emb|CAB55719.1|_5:224 ; 12 gi|6448717|emb|CAB61276.1|_24:243 ; 13 gi|7474000|pir||E75471_34:238 ; 14 gi|6273661|emb|CAB60175.1|_9:123 ; 15 gi|7649560|emb|CAB89035.1|_25:128 ; 16 gi|1717743|sp|P39796|TRER_BACSU_7:165 ; 17 gi|290543|gb|AAA62046.1|_4:169 ; 18 gi|7466601|pir||H65171_4:112 ; 19 gi|3915672|sp|P31460|DGOR_ECOLI_4:217 ; 20 gi|2623054|gb|AAC46002.1|_4:232 ; 21 gi|1945709|emb|CAB08003.1|_2:209 ; 22 gi|7480738|pir||T36777_6:210 ; 23 gi|123755|sp|P12380|HUTC_KLEAE_9:204 ; 24 gi|123756|sp|P22773|HUTC_PSEPU_13:187 ; 25 gi|4106575|emb|CAA21330.1|_16:188 ; 26 gi|401607|sp|P31453|YIDP_ECOLI_3:155 ; 27 gi|3025167|sp|P76420|YEGW_ECOLI_21:156 ; 28 gi|7470190|pir||S74897_55:169 ; 29 gi|1881415|emb|CAA66999.1|_3:95 ; 30 gi|7475928|pir||D69588_22:117 ; 31 gi|5616306|gb|AAD45715.1|AF160811_3_1:136 ; 32 gi|1763080|gb|AAB39643.1|_5:112 ; 33 gi|418474|sp|P32133|YIHL_ECOLI_4:80 ; 34 gi|3915501|sp|O31761|YMFC_BACSU_6:94 ; 35 gi|3916015|sp|P45544|YHFR_ECOLI_6:81 ; 36 gi|7428910|pir||B65132_28:103 ; 37 gi|3915562|sp|O32152|YURK_BACSU_6:77 ; 38 gi|7428911|pir||F69750_4:112 ; 39 gi|2668604|gb|AAB88607.1|_8:104 ; 40 gi|7443062|pir||C70710_19:93 ; 41 gi|7475898|pir||B69780_7:82 ; 42 gi|7475900|pir||E69838_11:89 ; 43 gi|7473653|pir||D75469_14:98 ; 44 gi|7480735|pir||T36493_6:93 ; 45 gi|7443060|pir||D70044_5:88 ; 46 gi|129347|sp|P13669|FARR_ECOLI_3:89 ; 47 gi|7480739|pir||T37185_4:75 ; 48 gi|7481476|pir||T34792_2:61 ; 49 gi|3688823|gb|AAC62421.1|_11:83 ; 50 gi|7443063|pir||D72336_7:89 ; 51 gi|3868868|dbj|BAA34256.1|_11:79 ; 52 gi|7428913|pir||G69999_5:91 ; 53 gi|7480737|pir||T36750_20:92 ; 54 gi|7476658|pir||A70555_11:85 ; 55 gi|7444908|pir||G69825_8:81 ; 56 gi|7444907|pir||F69778_12:79 ; 57 gi|7462964|pir||A72398_3:110 ; 58 gi|2127492|pir||S70089_5:87 ; 59 gi|7522189|pir||T35391_10:95 ; 60 gi|3947499|emb|CAA07150.1|_3:70 ; 61 gi|6007837|gb|AAF01064.1|AF189258_3_5:94 ; 62 gi|7649566|emb|CAB89055.1|_18:131 ; 63 gi|2496298|sp|P75532|Y101_MYCPN_5:84 ; 64 gi|6468718|emb|CAB61674.1|_28:124 ; 65 gi|7473145|pir||A75353_23:139 ; 66 gi|549814|sp|Q01856|YRDX_RHOSH_9:114 ; 67 gi|7475897|pir||H69777_24:153 ; 68 gi|2961083|gb|AAC05646.1|_6:170 ; 69 gi|7474001|pir||E75573_38:208 ; 70 gi|7473515|pir||C75540_21:173 ; 71 gi|6137032|emb|CAB59587.1|_12:198 ; 72 gi|7414556|emb|CAB86107.1|_6:221 ; 73 gi|731090|sp|P39161|UXUR_ECOLI_5:233 ; 74 gi|1174929|sp|P44487|UXUR_HAEIN_25:241 ; 75 gi|7531115|sp|Q9X9E0|EXUR_ERWCH_3:227 ; 76 gi|1706732|sp|P42608|EXUR_ECOLI_3:226 ; 77 gi|7449871|pir||C65098_8:231 ; 78 gi|6448745|emb|CAB61304.1|_16:170 ; 79 gi|4033500|sp|P70790|YTUX_AGRVI_27:167 ; 80 gi|2829657|sp|P77577|YDFH_ECOLI_9:217 ; 81 gi|4056664|gb|AAC98132.1|_33:233 ; 82 gi|98867|pir||JC1183_5:206 ; 83 gi|418524|sp|P32425|YIN1_STRAM_5:206 ; 84 gi|3915418|sp|O05494|YDHC_BACSU_6:208 ; 85 gi|6573304|gb|AAF17624.1|_17:227 ; 86 gi|7481541|pir||T36904_6:201 ; 87 gi|7480734|pir||T36491_5:209 ; 88 gi|7481483|pir||T35007_13:214 ; 89 gi|6468429|emb|CAB61589.1|_13:234 ; 90 gi|473782|dbj|BAA05571.1|_5:233 ; 91 gi|2119894|pir||I53482_5:234 ; 92 gi|461601|sp|P06957|PDHR_ECOLI_5:234 ; 93 gi|7688351|emb|CAB89840.1|_5:234 ; 94 gi|1707916|sp|P52072|GLCC_ECOLI_1:234 ; 95 gi|882509|gb|AAA69147.1|_21:254 ; 96 gi|1175615|sp|P42239|YCBG_BACSU_13:228 ; 97 gi|7481538|pir||T36849_10:223 ; 98 gi|1731210|sp|Q11159|Y494_MYCTU_19:235 ; 99 gi|7449872|pir||A70745_19:235 ; 100 gi|7462965|pir||B72377_9:203 ; 101 gi|7480729|pir||T34672_67:269 ; 102 gi|2147828|pir||I40749_12:209 ; 103 gi|2506556|sp|P54988|NTRA_CHEHE_4:188 ; 104 gi|78799|pir||S01288_1:239 ; 105 T0096 ; 106 gi|1651584|dbj|BAA36034.1|_1:205 ; 107 gi|1345956|sp|P09371|FADR_ECOLI_1:239 ; 108 gi|1438110|dbj|BAA12085.1|_1:123 ; 109 gi|1169604|sp|P44705|FADR_HAEIN_6:234 ; 110 gi|6468725|emb|CAB61681.1|_14:214 ; 111 gi|6523478|emb|CAB62259.1|_3:191 ; 112 gi|421645|pir||S30403_3:192 ; 113 gi|7481808|pir||T35462_9:124 ; 114 gi|538975|pir||G48652_9:122 ; 115 gi|7481736|pir||T36219_9:122 10 20 30 40 50 60 | | | | | | 1 HPTSYPTRYQEIAAKLEQELRQ-HYRCGDY.LPAEQQLAARFEVNRHTLRRAIDQLVEKGWVQRR 2 ------SLREQIREHILEGIISGRWQPGER.I-VERRIATELEVSQTPVREALRELESLRLIESA 3 ------SLREQIREHIVEGIVSGRWQPGER.I-VERRIATELEVSQTPVREALRELESLRLIESA 4 --PRTTKRGDQVAELIKGWINDGRVRPGKR.LNKEAELQQMFNVSRGSMRDALKALEVQGLVSLS 5 QPVTRRSVPEEVFEQIATDVLTGEMPPGEA.LPSERRLAELLGVSRPAVREALKRLSAAGLVEVR 6 ----SENVGRWLRDEIENSILSNEFSPGER.L-DETVLATRFGVSRTPVREALMQLDAIGLIEIR 7 RPLARKKLSEMVEEELEQMIRRREFGEGEQ.LPSERELMAFFNVGRPSVREALAALKRKGLVQIN 8 -PEAPVGRADEIVQRITEAIHLGLLDDGER.LPVEVDLAAQFGVAPMTVREALATLRELELVETR 9 MIVLPRRLSDEVADRVRALIDEKNLEAGMK.LPAERQLAMQLGVSRNSLREALAKLVSEGVLLSR 10 -LQKRRSIGADIAEKLQQLINDGTFKPGDR.LPGQRELAQQFGTSLAGVREAISVLSAAGLVDAR 11 -QRRRPPLAAAVVQSLATAIVLGQYPPGTA.LPSAGELCEEYEVSRTVIREATTTLAEKGLVATR 12 -PVVRESSVSEVAKRLLDHLSAGDIRPGTR.LPAERQLAEALGVARSSVRGALSALDVLGIIEIR 13 --QRPGLVREGVYQHLRRAVLDGEIAPGER.L-GEVELGQHLGVSRTPIREAIMRLTQDGLLVAE 14 -RSSPVPLYFQLSQQLEAAIEHGALTPGSL.LGNEIELAARLGLSRPTVRQAIQSLVDKGLLVRR 15 -RSSPVPLYYQLARQLEAAIEHGVLAPGNL.LGNEVDLSVRLGLSRPTVRQAIQSLVDKGLLVRR 16 ---------ITIYKDIAQQIEGGRWKAEEI.LPSEHELTAQYGTSRETVRKALHMLAQNGYIQKI 17 ------NKTDRIVITLGKQIVHGKYVPGSP.LPAEAELCEEFATSRNIIREVFRSLMAKRLIEMK 18 ------NKTDRIVITLGKQIVHGKYVPGSP.LPAEAELCEEFATSRNIIREVFRSLMAKRLIEMK 19 ------NKTDRIVITLGKQIVHGKYVPGSP.LPAEAELCEEFATSRNIIREVFRSLMAKRLIEMK 20 QKIESEKLASAVVRQIENLIVEGVLRPGER.LPSERELSERLAVSRPSLREAVAELQQEGLLTTR 21 -------------------IKNGELKPGDK.LDSVQALAESFQVSRSAVREALSALKAMGLVEMK 22 --PRRSALSEQVIAALRQQIASGEWPVGSR.IPTEPELVEQLGVARNTVREAVRALAHNGLLDIR 23 ---APAPFYEKVKQAISEKIHSGVWRPHDR.IPSEAELVAQFGFSRMTINRALRELTDEGLLVRL 24 MGEGPAPLYARVKQMIIQQIDNGSWPPHHR.VPSESELVNELGFSRMTINRALRELTADGLLVRM 25 --DIPAPIYQRVKLAIIRQIRTGTWQPHQR.VPSESELVTELGVSRMTINRALRELTNEGFLIRM 26 --------YKSIAERLRIRLNSADFTLNSL.LPGEKKLAEEFAVSRMTIRKAIDLLVAWGLVVRR 27 ----NTPLYIKFAETVKNAVRSGVLEHGNI.LPGERDLSQLTGVSRITVRKAMQALEEEGVVTRS 28 ---SEIPASKQLFDQIRFAIASRQYHPGHR.LPSTRQLAMMTGLHRNTISKVYQNLEDAGLVESI 29 ------PKYAQVKEEISSWINQGKILPDQK.IPTENELMQQFGVSRHTIRKAIGDLVSQGLLYSV 30 ---DMLPKYAQVKEEISSWINQGKILPDQK.IPTENELMQQFGVSRHTIRKAIGDLVSQGLLYSV 31 MKEKTLPKYLQLKQEILSWIISGQMKPDEK.IPTEHEIANQFQLSRHTVRQALGELEKEGWLYKI 32 --PGDIPQYLLIKAQLQARIQSGALKSGDK.LPSERELCAIFNTTRITIRESLAQLESSGLIWRA 33 ----NQSTVENAKEKLDRWLKDGITTPGGK.LPSERELGELLGIKRMTLRQALLNLEAESKIFRK 34 ---DNRHLYLKVIERIKEDIKNGIYTEKEK.LPSEFELSKKLGVSRATLREALRILEEEHVIIRR 35 -RYSHQLLYATVRQRLLDDIAQGVYQAGQQ.IPTENELCTQYNVSRITIRKAISDLVADGVLIRW 36 -RYSHQLLYATVRQRLLDDIAQGVYQAGQQ.IPTENELCTQYNVSRITIRKAISDLVADGVLIRW 37 ---SSTPLYIQLKQIITDDIKKGVYSPTAK.LPTENELCTKYNVSRITVRKAILDLVEEGYLIRQ 38 -------LYSVIKFKIIELIKSGKYQANDQ.LPTESEFCEQYDVSRTTVRLALQQLELEGYIKRI 39 ----------QLVQRILADIQVGKLADGQRkLPAEPVLMERYQVTRYTLRQALKQLSNMGYTYQM 40 ----SVPASTQLAEALKAQIIQQRLPRGGR.LPSERELIDRSGLSRVTVRAAVGMLQRQGWLVRR 41 KKMKKLPKYRQIVHFIKEKIGNGEWPIGSK.IPSQRTLAKDFQVNRSTVITALEELMADGLIEGT 42 --KSDVPLHRQIEQYMKDKILHGEWAVGTK.IPSQRTLADMFQVNRSTVTAAIDELTSQGLLEGR 43 ---GPSPIHLQLAAQLREAALAGQLLPGSL.LPGTRTLARDLGVTRGVVEAAYALLSADGTLQGE 44 DKTDTRPLHEQVAGALRRAIAEGECAPGDR.LPSARDLSEALDVNVNTVLRALRGLRDEGLLEFR 45 -KQSPIPIYYQIMEQLKTQIKNGELQPDMP.LPSEREYAEQFGISRMTVRQALSNLVNEGLLYRL 46 ----HKPLYRQIADRIREQIARGELKPGDA.LPTESALQTEFGVSRVTVRQALRQLVEQQILESI 47 -IQRPGALYQQVAAAIRDAILSGEFAPESL.LPSEAQLMARYQVSRPTVRNAIAALRAEGLIDVR 48 ------------AEIISKRIADGTYPPGTR.VPGIVELSAEFGIAASTAQKALAHLRGTGEVRTE 49 ---SRTPIYHQIEEQIKALIVSGHVSAGTP.LPSIRALSKDLACSVITTRRAYQNLEQQGYIKTS 50 -FHSSKPIYEQIKERIKLLILSGKLKEGEF.VPSIRSLAEDLGVNLNTVARAYRELVQEGVLEVR 51 ----DKPKYVQISQKIKVIIERGIINDGEK.LPSIRKLSELLNVNKDTVINAYRKLEEEGYAIQK 52 DPRSSTPIYEQIIQQMKELCLKGIMKPGDK.LPSVRELATIIIANPNTVSKAYKELEREGIIETL 53 -VDDGAPPYEQVRAQISEQARSGALPVGYR.LPTVRGLAESLGLAANTVAKAYRALEADGVIETR 54 -VKAGKPLFDQLRTQVIDGVRAGALPPGTR.LPTVRDLAGQLGVAANTVARAYRELESAAIVETR 55 DKKSKTPLYEQLYTFFKQEISHARITKGTR.LPSKRRLSSLLDVSTATIERAYEQLTAEGYVKSK 56 ----DIPLYQQLYRYFKENMHRGRIQKGMK.LPSKRLLANQLSISQTTVERAYEQLAAEGYIVSK 57 -----------------DEIKSGKYKHGDK.LPTEKELMERFNASRETVRKALERLVVKNLVIRK 58 --------REDIAGQLRERILAGDLKPGER.LPSTRELVAQHGGSRTTANQALRLLAAEGLVALR 59 --VTRSTLRQQIADALRDEVLAGRLQPGQE.F-TVKEIAEQYGVSATPVREALVDLSAQGLLDAD 60 ------PKTQAAYVIISGWIATGRYGPGDK.LPSERAMCEDLGIGRTALRQVLAKLVAEGILEVH 61 ----EVSLTAQIQRFIKNEISEGVLHPGTR.LPSSRALADDLDVSRSVVVEAYGQLVAEGYLEAT 62 ----GPGLRRGLTDALREAVRTGRLGPGTR.LPSSRVLAADLGIARNTVADAYADLVAEGWLTAR 63 --KEQAKKGQIIYRYILLKIQSFKWPAGTR.IFSERQLEIRFASSRSLIRTILNTLLGKDLIRHT 64 -GTRRPPAYRALADGIRLLVLEGRVPVAAR.LPAERELALALTVSRTTVAAAYEALRAEGFLESR 65 -PETGEALHTRTERTLRAAIGQGRLPQGTR.LPGHRALAAALGVSRNTLVDALAQLEIEGYVEVR 66 ---TARLKYLGIVDALEADIRAGRVTPGER.LPPQRAIAEALGVDLTTVTRALNEAQRRGLVSAQ 67 ----EKPIYKALAGQLEQDILNGVLLPGTK.LPPQRELADYLDLNVSTISKAFKVCELKGLLSAT 68 -PLIKRSLVDQALEQLRWRISEGRWAIGER.LPTEPELAAELGISRNTVREAMRVLAFSGLIEIR 69 DPADAAPAYVQLAQGLRRRIESGELSAGTA.LPAERELAARLGVSRVTLRQGLGLLEAEGLLRRR 70 -PEARMAKYPLIKTTLKDRLLGGHYPEGLP.LPSEPQLAREFEVSRMTARRAIDELEREGYVYRV 71 --LKRERVRDAVLELIEDR------RPGDA.IPSERTLCAELGVSRPTLRAAIDELVVAGLLVRE 72 RPMTKQRLYEQVLERLRQYVADGGLRAGDR.LPPERDLAQRLGVSRASVKQAIVVLEVQGLVEAR 73 --TSAQRPYQEVGAMIRDLIIKTPYNPGER.LPPEREIAEMLDVTRTVVREALIMLEIKGLVEVR 74 -------TYTRIGQLLKQDISQGIYSIGDK.LPTEREISEKFGVSRTIVREAMVMLEVEKLVEVK 75 -LTESRRLYQQLAAELKQRIENGVYPVGDK.LPAERNISEEMNVSRTVVREAIIMLEVEGYVEVR 76 -ITEPRRLYQQLAADLKERIEQGVYLVGDK.LPAERFIADEKNVSRTVVREAIIMLEVEGYVEVR 77 -ITEPRRLYQQLAADLKERIEQGVYLVGDK.LPAERFIADEKNVSRTVVREAIIMLEVEGYVEVR 78 ---PRAERARALADALRQQITDDAFADG-V.LPDERDLGRRFGASRNAVRDALALLREEGLITRR 79 --VSSAGRVSAAYHAIRNAIRTNVFPPGYQ.A-AEIEIARQLGMSRTPVHEAMARLQEDGLVRIL 80 ---PTQPVNQQIYRILRRDIVHCLIAPGTP.L-SEKEVSVRFNVSRQPVREAFIKLAENGLIQIR 81 ----RGSARDQLYEMLKEKILRLELEPGTK.I-SEKEIAQQLHISRTPVREAFLKLAQEELLDII 82 ---NGRTNRRDIYLKLRQMVLTLELAPGAA.L-SENELAASMGVSRTPVRESLILLAQEGLVQVF 83 ---NGRTNRRDIYLKLRQMVLTLELAPGAA.L-SENELAASMGVSRTPVRESLILLAQEGLVQVF 84 -LDKPTPYYLQFYNQLKKMIFNGTFKPGER.I-NETQLAKSFGVSRSPIREAMRLLEKDGLLKAD 85 -PQPKKLPLELVFEELRNLILSGRFAAGAK.LPSEAKLAAKYGVSRPIVREALRSLQILGLTETR 86 --TPIPSRTQYVLEEIKRRILTGRLTPGQA.L-VETDLAAQFGVSKTPVREALKTLAGTGLVVMS 87 --VKQPPAADRVYTHVKQGVLERRYEGGTL.L-TEGELAEAVGVSRTPVREALLRLEAEGLIRLY 88 RLERPGPLRDRVYEALLELITTRALQPGQH.L-VESELAGHLGVSRQPVREALQRLNTEGWVDLR 89 -----PTMQQRVVDELGRRIVGGAWEPGVP.LPVEDALAAEIGVSRGVLREAVKALAAKGMLHVR 90 -KIRQPKLSDVIEQQLEFLILEGTLRPGEK.LPPERELAKQFDVSRPSLREAIQRLEAKGLLLRR 91 -KIRQPKLSDVIEQQLEFLILEGTLRPGEK.LPPERELAKQFDVSRPSLREAIQRLEAKGLLLRR 92 -KIRQPKLSDVIEQQLEFLILEGTLRPGEK.LPPERELAKQFDVSRPSLREAIQRLEAKGLLLRR 93 -KIRQPKLSDVIEQQLEFLILEGTLRPGEK.LPPERELAKQFDVSRPSLREAIQRLEAKGLLLRR 94 MKDERRPICEVVAESIERLIIDGVLKVGQP.LPSERRLCEKLGFSRSALREGLTVLRGRGIIETA 95 MKDERRPICEVVAESIERLIIDGVLKVGQP.LPSERRLCEKLGFSRSALREGLTVLRGRGIIETA 96 --VNRKTLAKQVIERIVHLLSSGQLRAGDK.LPTEMELMDILHVSRPVLREALSSLETLGVITRK 97 RPVRAGNGFEEALEQILQVVRLGLVAAGER.LPAERELAERLGISRVTLREVLRVLQDQGLVQAR 98 QPPDRQRVDERIATTIADAILDGVFPPGST.LPPERDLAERLGVNRTSLRQGLARLQQMGLIEVR 99 QPPDRQRVDERIATTIADAILDGVFPPGST.LPPERDLAERLGVNRTSLRQGLARLQQMGLIEVR 100 -------VRTKVYNLLKEMILNHELKLGEK.L-NVRELSEKLGISFTPVRDALLQLATEGLVKVV 101 -LVQRSSVRGQILDALRSALVTGELRPGEV.Y-SAPVLGERFGVSATPVREAMQQLALEGAVEVV 102 --------AAKLYEHLKEMAVSYHFRPGER.I-NEVELAAQLKVSRTPLREALNRLTTEGFLTTT 103 ---------------------SYHFRPGER.I-NEVELAAQLKVSRTPLREALNRLTTEGFLTTT 104 MVIKAQSPAGFAEEYIIESIWNNRFPPGTI.LPAERELSELIGVTRTTLREVLQRLARDGWLTIQ 105 MVIKAQSPAGFAEEYIIESIWNNRFPPGTI.LPAERELSELIGVTRTTLREVLQRLARDGWLTIQ 106 MVIKAQSPAGFAEEYIIESIWNNRFPPGTI.LPAERELSELIGVTRTTLREVLQRLARDGWLTIQ 107 MVIKAQSPAGFAEEYIIESIWNNRFPPGTI.LPAERELSELIGVTRTTLREVLQRLARDGWLTIQ 108 MVIKAKSPAGFAEKYIIESIWNGRFPPGSI.LPAERELSELIGVTRTTLREVLQRLARDGWLTIQ 109 DILKAQSPAALAEEYIVKSIWQDVFPAGSN.LPSERDLADKIGVTRTTLREVLQRLARDGWLTIQ 110 -LLGRTSTAERVSDILRSRIAEGYFPPGTR.L-SEDSIGGALGVSRNTLRESFRLLTHERLLVHE 111 KIERSAPPYMQVVTHFRTRIMSGELSPGDA.LPTDRGLAEEWGVSRATAQKALTVLKTEGLIEAV 112 KIERPLPPYMQVIAHIRDQIDSGELRAGDL.IPSDRNIAQEWGISRATAQKVITALKAQGLVEAV 113 ---RSGPRYVQVADEIVQQIRAGVLKPGDM.VPSESEMVDRYGVSGGTIRKAMVEVRASGLVETR 114 ---RSGPRYVQIADEIVQQIRAGVLKPGDM.VPSESELVDRYGVSGGTIRKAMVEVRASGLVETR 115 ---RSGPRYVQIADEIVQQIRAGVLKPGDM.VPSESELVDRYGVSGGTIRKAMVEVRASGLVETR 70 80 90 100 110 120 | | | | | | 1 QG..VGVLVLMRPFDYPLNAQARFS-------------------------QNLLD..QGSHPTSE 2 PN..KGVRVR-------------------NLTAADLEESYPVRAGLEAIAAELAA..DRLALDCS 3 PN..KGVRVR-------------------NLTAADLEESYPVRAGLEAIAAELAA..ETLAESCE 4 TGpeGGATITRVPLARAFQALQNYL----FFENVTLEELYAVRRTLEPIVAAGAVa.HLTDADFE 5 QG..DVTTVRDFRRHAGLDLLPRLLFRNGELDISVVRSILEARLRNFPKVAELAA..ERNEPELA 6 PR..RGAIVI-------------------DPGPHRVYEMFEVMAELEGLAGSLAAr.RLDKTSRE 7 NG..ERARVSRPSADTIIGELSGMA-KDFLSHPGGIAHFEQLRLFFESSLVRYAA..EHATDEQI 8 RGrsGGSFVRRPAGPPVEKLTARLA----AMSASDLRDLFDEHTAIAGQAARLAAe.RAAPSTVR 9 RG..GGTFIRWRHDTWSEQNIVQPLKTLMADDPDYSFDILEARYAIEASTAWHAAm.RATPGDKE 10 PG..RGTVVRS----VGGAVPTFDGWLGAVGDEQEFEELMQARRMLEAFTIAQAVa.RATPAQVS 11 QG..WGTVVLGQDQWSLLDPLVLDALFQRADRLVYLDNLIEIRTTLECAMAARAAg.RIDEEQSA 12 PG..SGSYVRE----GTSEFLPRAINWGLMLGQRRTRDLVEVRTHMEGVSARLAAe.RATDADVA 13 AN..KGARVR-------------------LLSAAEARDTYAVREELDGLAAALAAa.QHTPDDAH 14 RG..VGTQVV-------------------HSKVRRPLELSSLYDDLEAAGQRPAT..KVLVNTVV 15 RG..VGTQVV-------------------HSQVRRPLELSSLYDDLEAAGQDPGT..RVVRNED- 16 RG..KGSVVLN--------------REKMQFPVSGLVSFKELAQTLGKETKTTVH..KFGLEPPS 17 RY..RGXFVAPRNQWNYLDTDVLQWVLENDYDPRLISAMSEVRNLVEPAIAVAXAe.RATSSDLA 18 RY..RGAFVAPRNQWNYLDTDVLQWVLENDYDPRLISAMSEVRNLVEPAIARW--..-------- 19 RY..RGAFVAPRNQWNYLDTDVLQWVLENDYDPRLISAMSEVRNLVEPAIARCGAe.RATSSDLA 20 AG..SGIFVAEVLGSAFSPALIRLF----ARNDQAVFDYLAFRRDLEGMAAERAAk.MGSDTDLK 21 QG..EGTYLKEFELNQISQPLSAAL----LMKKEDVKQLLEVRKLLEIGVASLAAe.KRTEADLE 22 QG..SGTYVVATSELAG--------VMQRRFADADPRDIAELRSTLESAAARLAAe.RRTEKDLK 23 QG..VGTFVAEPKGQSAL-------------------------FEVRSIAAEIVA..RHHQHRCE 24 QG..VGTFVAEPKGRSAL-------------------------FEVNNIADEIAA..RGHQHSCQ 25 QG..VGTFVAEAKAHSAL-------------------------LEVHNIADEIAA..RGHRHSSQ 26 HG..SGTYLVRKDVLHQTASLTGLV---------------EVLKRQGKTVTSQVL..------IF 27 RG..YGTQINNIFEYSLK----------------------EARGFSQQVVLRGKK..PDTLWVNK 28 AG..SGIYVKAPSTEEGM-----------ILDGPLFREYPEASQLIQKTIDELLGq.GLNLSQVK 29 QG..GGTFVASRSAKSALHSNKTIGVLTTYISDYIFP------------------..-------- 30 QG..GGTFVASRSAKSALHSNKTIGVLTTYISDYIFP------------------..-------- 31 QG..SGTFVSRPKPKEQVDTKTIGIVTTYISDYIFPHIVRGAEETLREKGYRLLL..ASTNNDKQ 32 DR..RGWFVTPERLWLD-------PT-----------------------------..-------- 33 DR..KGWFVTQPRFNYSP-----------E-------------------------..-------- 34 HG..VGTFVHSK-----------------PLFLSGIEQLNSVTKMIE--------..-------- 35 QG..KGTFVQSQKVE----------------------------------------..-------- 36 QG..KGTFVQSQKVE----------------------------------------..-------- 37 QG..KGTFVKSPK------------------------------------------..-------- 38 QG..KGTFVSAAKIQTPIPHKITSFAEQM----RGLR--------SESKVLELVV..IPADHSIA 39 HG..IGTFVRQQQTNNSI-----------ALQHDGGLSEAAARAGLKLATKKAVM..-------- 40 QG..LGTFVADPVEQEL--------------------------------------..-------- 41 MG..KGTVVINNTW-----------------------------------------..-------- 42 KG..GGTKVVNSTWSVLTA------------------------------------..-------- 43 VG..RGTRVSRGVGRTAQAAAPSPAW-----------------------------..-------- 44 RG..RGVTVAE-----------------------GARPHSELQIRVREL------..-------- 45 KG..RGTFVSKPKMEQALQGLTS--------------------------------..-------- 46 QG..SGTYVKE------------------ERVNYDIFQLTSFDEKLS--------..-------- 47 HG..KGSFVRS--------------------------------------------..-------- 48 LG..LGTFVA---------------------------------------------..-------- 49 QG..RGTFVAEIDE-----------------------------------------..-------- 50 RG..EGYVVSKVNVEKIRTQLE---------------------------------..-------- 51 IG..SGTYAKK--------------------------------------------..-------- 52 RG..RGTYISENAKTTLVEGKMTMI------------------------------..-------- 53 GR..NGTFVAA-------------------A------------------------..-------- 54 GR..FGTFISRFDP-----------------------------------------..-------- 55 PK..IGWFAAEV-------------------------------------------..-------- 56 PR..SGWFAD---------------------------------------------..-------- 57 PG..LGTFVNIEKKNKVVGILVQQ-----ITSYIFPYIALGAEEVLFANGYKMLL..GNASEDPH 58 EK..SAAVVLAPEDAGKTPESRL--------------------------------..-------A 59 HH..RGFRVH-------------------EYSVDDFRGMIEARSLV---------..-------- 60 QR..SAYRVPSG-------------------------------------------..-------- 61 RG..AGTRVGPHLA----EPAVVPALLDAGSGPETR-------------------..-------- 62 QG..SGTRVADRVAAPPAEASARRP-----------REPARPLHDLRPGSPDLAS..FPRVEWLR 63 KGn.AGYFVAKNAGFSFFH------------------------------------..-------- 64 RG..AGSWTAVPAGNPL---------------PARGLEPLPPEALGSVIDL----..-------- 65 GR..SGTRVCVPPDEAAPPSPPPLP------------------------------..-------- 66 VG..RGTFVRDEPAGDEGGGTPLDLSMNIPPQPAEP----DLRRILPQGIA----..-------- 67 VG..SGTFVS----------------YDALSNAYLLEDTKPTH-LIE-----MGAi.LPDHASYE 68 QG..DGSYLR-----SMTDPLGAMR----ALSHCTLEQAQETRQILEVEAVGLAAv.RRTEADLT 69 RG..SGTFVAGTPHTSRQLGLLSSF-------------SDEVRAQGGVPGARVLSf.TQGRPTPQ 70 QG..AGTF---------------------PTGKRFRQGVFRVRPFKE------WA..RHPDHRTT 71 HG..RGMFVAAEKITQ---------------------ELLSDRRAFSLPQAAGAW..T---SRLL 72 HG..GGTYLVR-------DSLDVEPVEKMVERRRRLPDVLEAREALETKLAELAAe.RRTEDDLA 73 RG..AGIYVLDNSGSQNTDSPDAN-----VCNDAGPFELLQARQLLESNIAEFAAl.QATREDIV 74 KG..SGVYVVRTPESIHMEHS--------DLPDVGPFELLQARQLLESSIAEFAAl.QATKKDIL 75 KG..SGIHVISNQQRHLLAANGSDA----DFLTAGPFELLQARQLIESNIAEFAAt.QVTRQDII 76 KG..SGIHVV-----SNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAAt.QVTKQDIM 77 KG..SGIHVV-----SNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAAt.QVTKQDIM 78 RG..VGTTVLLPKYAHGLDRLTGLA----EELTGRGTVTNEVRVAVEVPALPAAIas--R----- 79 PK..KGIIIC-------------------ALSPADIEEIYEVTIALEGAAASRLA..MIDAPVKA 80 PQ..RGSYVN-------------------KISMAQVRNGSFIRQAIECAVARRAAs.MITESQCY 81 PQ..SGTIVS-------------------RINLEHVEEGRFIPEVVEKEVAVLACt.KLRQDHLF 82 PK..IGSFVS-------------------RVDPARVADAQFLREAVELGSLDALPa.ELDPAVVG 83 PK..IGSFVS-------------------RVDPARVADAQFLREAVELGSLDALPa.ELDPAVVG 84 DR..NGFSIT-------------------SLTAKDVDEIYKIRIPLEQLAVELVId.EADEEELT 85 TG..SGTYVLAAAGDGDI-----------RYGNYSARDLMEARAFVEVSAAGWAAl.RRTDDELS 86 QY..KGVTVR-------------------MVDADMAREVYDVRLLLEPEALRRAVr.--REASLD 87 PK..KGALVL-------------------PVSAQEIADVVETRLLVEEHAARKAV..PAPPGLVE 88 PA..QGAFVH-------------------EPTEEEADQLLTVRTLLEAEAARLAAa.NASSAGIA 89 PR..TGTRVLSPEHWNHLDRDVLRW-KQAGDATALLRDTSELRRIVEPEAARLAAe.RAGSEDVR 90 QG..GGTFVQSSLWQSFSDPLVELL----SDHPESQYDLLETRHALEGIAAYYAAl.RSTDEDKE 91 QG..GGTFVQSSLWQSFSDPLVELL----SDHPESQYDLLETRHALEGIAAYYAAl.CSTDEDKE 92 QG..GGTFVQSSLWQSFSDPLVELL----SDHPESQYDLLETRHALEGIAAYYAAl.RSTDEDKE 93 QG..GGTFVQSSLWQSFSDPLVELL----SDHPESQFDLLETRHALEGIAAYYAAl.RSTDEDKD 94 QG..RDSRVARLNRVQDTSPLIHLF----STQPRTLYDLLDVRALLEGESARLAAt.LGTQADFV 95 QG..RDSRVARLNRVQDTSPLIHLF----STQPRTLYDLLDVRALLEGESARLAAt.LGTQADFV 96 TR..GGTYFNDKIGMQPFSVMLALA-------TDNLPAIIEARMALELGLVTIAAe.KINEEELQ 97 RGryGGTFVLPRADAGGEDELRR------RVAGVDIEDVLRFREVLEAGAAGLCAahGLAGARAA 98 HG..SGSVVRDPEGLTHPAVVEALVR---KLGPDFLVELLEIRAALGPLIGRLAAa.RSTPEDAE 99 HG..SGSVVRDPEGLTHPAVVEALVR---KLGPDFLVELLEIRAALGPLIGRLAAa.RSTPEDAE 100 PR..VGFFVT-------------------DVDEKFIRETIETRIMMEVFCLENYFdkIAGSEELL 101 PN..RGFRVL-------------------ERGDRELAELAEVRALIEVPVWLRLAr.TVPAEHWA 102 AN..KGFFAR-------------------VLEANTLFDLYELRAFLEQSAVRLACq.RATDQEIA 103 AN..KGFFAR-------------------VLEANTLFDLYELRAFLEQSAVRLACq.RATDQEIA 104 HG..KPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAF..RQHPDKAQ 105 HG..KPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAF..RQHPDKAQ 106 HG..KPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAF..RQHPDKAQ 107 HG..KPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAF..RQHPDKAQ 108 HG..KPTKVNQFMETSGLHILDTLMTLDVDNATNIVEDLLAARTNISPIFMRYAF..KANKEN-- 109 HG..KPTKVNNIWDAAGPNIIETLIALDMQSAPLIIDNMLSLRSKMSESYIYEAV..KNSPQKST 110 LN..RGVFVR-------------------VLTVEDVEDIYRTRSLVECAVVRGLGepPYPLDGLA 111 QG..SGTRVR----------------QSAPLHHNGHDRAVSVRRTGRIYAEGEYA..RITSASLE 112 QG..SGTRVRAAAD---------------HLHRSGRDRAASVRRTGRIYTAGEYA..RIVSAELA 113 HG..KGSIVKDRPPVRHRSSDRFRRSLRQGGKAAYLAE-----------------s.EQSGATAK 114 HG..KGSIVKDRPPVRHRSSDRFRRSLRQGGKAAYLAESAQSGATAKVSVLYIGP..-------- 115 HG..KGSIVKDRPPVRHRSSDRFRRSLRQGGKAAYLAESAQSGATAKVSVLYIGP..-------- 130 140 150 160 170 180 | | | | | | 1 KLLSVLRPAS........GHVADALGITE---------GENVIHLRTLRRVNGVALCLIDHYFAD 2 ALEPHVAALYeadrv...SDGTGQVRHTVGFHRELVRAAGNSVLLHTWEGLGIEV---------- 3 ALEPHVAALYeadqa...QDGTGQVRHTVGFHRELVRAAGNSVLLHTWEGLGIEV---------- 4 ALERSISVCEpfvagh..EQALDQRCEDIHFHDVLAAAHPNAFLRCLCRIINQMLHSL------- 5 ELLQDSLRALdte.....EDPIVWQRHTLDFWDHVVDSAGSIVDRLMYNAFRAAYEPTLAALTTT 6 AITATHGRCEksaaa...GDSDAYYYDNEEFHKAIYAAGRSDFLEEQCLQLHRRL---------- 7 DLLAKALEINsqsl....DNNAAFIRSDVDFHRVLAEIPGNPIFMAIHVALLDWL------IAAR 8 RLFALTDQLDta......TSLRDRIRADSRFHIQVAVAAQSARLARREANLQAEVSGL------- 9 KIQLCFEATLs.......EDPDIASQADVRFHLAIAEASHNIVLLQTMRGFFDVLQSSVKHSRQR 10 DLRGAVEAMRavm.....GSAGAYAEADMQLHLLLSEVAGNRVVTRLMRAIQRPLMEQLRRSIAH 11 ALSAKLDELAgli.....DDPEAYSRADIEFHEIIHHASRDAFGRAIVSSIQGKAVRS------- 12 RLEEHLQHMRdag.....GDVTAFIDADIAFHLETARIARNTVLSDILHSIRALLQVWME----- 13 ALSAALRALNavqg....EDYREQTRLDLAFHRAITHAAHNAALTDLARNLEQRVALI------- 14 PATAEIAAAL........----------------------------------------------- 15 ----------........----------------------------------------------- 16 ELIQKQLRANld......DDIWEVIR---------------------SRKIDGEHVILDKDYFFR 17 QIESALNEMIann.....QDREAFNEADIRYHEAVLQSVHNPVLQQLSIAI-------------- 18 ----------........----------------------------------------------- 19 QIESALNEMIann.....QDREAFNEADIRYHEAVLQSVHNPVLQQLSIAISSLQRAVFERTWMG 20 VIDAILTRMEtahgk...RNPADEAALDAQFHMAIVEASHNIIMLHMMRAMFDLL--------SE 21 RIQDALKEMGsie.....ADGELGEKADFAFHLALADASQNELLKHLMNHVSSLL-------LET 22 QIDGLLLRREeawes...GDAEAFVSADATFHLAVVAASHNNVMTAMYADLGEVM---------- 23 VLLLEETRADhiq.....ATALSVPE------------GTRIFHSLMVHYENEVPVQIEDRCVNA 24 VITLTEEAAG........SERALALD---------MREGQRVFHSLIVHFENGVPVQIEDRYVNA 25 VLHLEARPASp.......EEAIALG----------IQPGQQLFYSQIVHYENDFPVQVENRCVNP 26 EIMPAPPAIA........SQLR-------------IQINEQIYFSRRVRFVEGKPLMLEDSYMPV 27 RVVKCPEEVA........Q-------------QLAVEAGSDVFLLKRIRYVDEEAVSI------- 28 ELC-------........----------------------------------------------- 29 ----------........----------------------------------------------- 30 ----------........----------------------------------------------- 31 REKEQLEEMIr.......----------------------------------------------- 32 ----------........--------QNTNFHKLCREQGREPKTALLSGVLTTVP---------- 33 ----------........----------------------------------------------- 34 ----------........----------------------------------------------- 35 ----------........----------------------------------------------- 36 ----------........----------------------------------------------- 37 ----------........----------------------------------------------- 38 ELL-------........----------------------------------------------- 39 ----------........----------------------------------------------- 40 ----------........----------------------------------------------- 41 ----------........----------------------------------------------- 42 ----------........----------------------------------------------- 43 ----------........----------------------------------------------- 44 ----------........----------------------------------------------- 45 ----------........----------------------------------------------- 46 ----------........----------------------------------------------- 47 ----------........----------------------------------------------- 48 ----------........----------------------------------------------- 49 ----------........----------------------------------------------- 50 ----------........----------------------------------------------- 51 ----------........----------------------------------------------- 52 ----------........----------------------------------------------- 53 ----------........----------------------------------------------- 54 ----------........----------------------------------------------- 55 ----------........----------------------------------------------- 56 ----------........----------------------------------------------- 57 KERQI-----........----------------------------------------------- 58 EARTE-----........----------------------------------------------- 59 ----------........----------------------------------------------- 60 ----------........----------------------------------------------- 61 ----------........----------------------------------------------- 62 AARR------........----------------------------------------------- 63 ----------........----------------------------------------------- 64 ----------........----------------------------------------------- 65 -LSAWARRALggqv....EDAGGEYEFDLRIGQPVP----------------------------- 66 ----------........----------------------------------------------- 67 PLLYQ-----........--------------------------------------------LKN 68 ALHEALKASAvlyh....GDLEAYISADLLFHKRLVDAAHNPALSELYQYFSA------------ 69 EALSLGLT--........-------------------AAEQVYRLRRLRTSDGDPLAVEDSTLPA 70 VLRAMQIEAT........PEIAVILQID---------PGDPVIFVHRLRTAGDEALVIEKRYINA 71 EVRTLPAGARvg......RKLRMSP-------------AAQIHYVARLRLVDGSPMAIEYLHVPA 72 AMRSALAVMAeei.....DRDGHGVEGDRLFHAAVTAAAHSSLLAEFMRSIAHQI---------- 73 KMRQALQLEErelas...SAPGSSESGDMQFHLAIAEATHNSMLVELFRQSWQWR-------ENN 74 NLKQILNREKell.....TQNQDDYSADKDFHLALAEITQNDVLVKLQEQLWQYR-------FNS 75 QLMEIQENARq.......EDRFRDSEWDLKFHVQVALATQNSAMATIVEKMWSQR-------IHN 76 KLMAIQEQARg.......EQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQR-------SHN 77 KLMAIQEQARg.......EQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQR-------SHN 78 ----------........---------------LEVPAGAGGVYVERLRRLDGLPLSLDTSYLTV 79 EVVALLRDATeam9alerNDLPGWAAADERFHETLVA---------------------------- 80 QLEQNLHQQRiaier...KQLDDFFELDDNFHQLLTQIADCQLAWDTIENLKATVDRV------- 81 EMEKNIAMQElcaek...GNFLELFELDEKFHQLIYDGCRMSRSWKMVQSLNSHFNRL------- 82 ELRDNLVRQGrkd.....LDLEEFFGLDEAFHQGLMRLSGHGNVWTTVAAAQGHL---------- 83 ELRDNLVRQGrkd.....LDLEEFFGLDEAFHQGLMRLSGHGNVWTTVAAAKGHL---------- 84 ILEKQLEETEkaihng..TEDTEIIRLNQKFHELLVDFSHNRHLKNLLEHVNDLI---------- 85 RLLHLCDRMEqe......EDTGAWVRLDSDFHGLIAEASKNAVFRDIVDDVREAM---------- 86 AAREALNRADra......TDTAERSLANREFHRALYVPCGNPLLGRMLDEVRDQAALV------- 87 RLEELLARQQeqaaa...GDFAAASVTDRCFHAEIVRSGGNEILSRLYDQLRDRQLRM------- 88 ALEALCEEGEravaa...EDVDAAVACNARFHGKVMELAGNAVLAELAAQVDRRV---------- 89 VLYDALNAMEaaaar...PGRRGYVEADIAFHRALLDAGGNRLLGSLGRAVEIAL---------- 90 RIRELHHAIElaqqs...GDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQNVRQNFEL 91 RIRELHHAIElaqqs...GDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQNVRQNFEL 92 RIRELHHAIElaqqs...GDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQNVRQNFEL 93 RIRELHHAIKlaqes...GDLDAESEAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQNVRQNFEL 94 VITRCYEKMLaasennkeISLIEHAQLDHAFHLAICQASHNQVLVFTLQSLTDLMFNSVFASVNN 95 VITRCYEKMLaasennkeISLIEHAQLDHAFHLAICQASHNQVLVFTLQSLTDLMFNSVFASVNN 96 RLQKTIDDIAn.......STDNHYGEADKEFHRIIALSANNPVVEGMIQSLLITH---------- 97 RLRDALAGTRd.......APLAQYRRLDTMLHLTLAELCGSPALAAQYAAVRATLNDLLDCIPLL 98 ALCAALEVVQqa......DTAAARQAADLAYFRVLIHSTRNRALGLLYRWVEHAF---------- 99 ALCAALEVVQqa......DTAAARQAADLAYFRVLIHSTRNRALGLLYRWVEHAF---------- 100 EIKGEIDDVEks......AKREIFDDSDERLHKLFIRASGNELIISLYEKIWDRI---------- 101 ELRPLAEGTVraass...GCPATYAEADRAFHRAALALAGNEQLVRIAGDVHRRAQWP------- 102 VLRDFLLEQDesge....ISAGEMLKLDEEFHFRLVGLSQNEELLKTVRSISERI---------- 103 VLRDFLLEQDesge....ISAGEMLKLDEEFHFRLVGLSQNEELLKTVRSISERI---------- 104 EVLATANEVA........DHADAFAELDYTIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFAN 105 EVLATANEVA........DHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFAN 106 EVLATANEVA........DHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFAN 107 EVLATANEVA........DHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFAN 108 ----------........----------------------------------------------- 109 ALFAELEQLQ........NTAQDYTEFDYQLFRQFTVVANKPFYRLIFNSLKGVYQRIGLLFFKE 110 EAVEDGRRSAre......GDWKGVGTANIHFHRELVALAGSERTDELMRSVFAEL---------- 111 PAPADVAEALgie.....EGAPAIRR------IRVTYNASDVALSMSTSWLDGALSSTAPALVST 112 PAPADVAEVLsvq.....EGAAVIRR------IRITYNAENQPISASTSWYDGNLAAAAPKLLKT 113 VSVLYIGPME........----------------------------------------------- 114 ----------........----------------------------------------------- 115 ----------........----------------------------------------------- 190 200 210 220 230 | | | | | 1 LTLWPTLQRFD......SGSLHDFLRE---..--------------------------------- 2 --FTALSIRWL......GT-VQQSYAEEHE..ELVAAFRRRDPRIPEIV---------------- 3 --FTALSIRWL......GT-VQQSYAEEHE..ELVQAFQRRDPRIAELVKAHV------------ 4 VIVAGNVTQRD......YQAFGRTTLAAHR..AILEAARRRDAQAVERLMAAHMDEAEAQL---- 5 MTAAAKRPSDY......RK-----------..-LADAICSGDPTGAKKAAQDLLELAN------- 6 --RPDRRLQLR......VRNRLSTSFLEHC..AIVDAIFAGDGDEARRLLRGHVGIQGER----- 7 PTVTDQALHEH......NN----VSYQQHI..AIVDAIRRHDPDEADRALQSHLNSVS------- 8 -----IWLPIG......PPIDVAAYVEEKH..AISAAIAAENAQEARQLAEAH------------ 9 MYLVPPVFSQL......TE--------QHQ..AVIDAIFAGDADGARKAMMAHLSFVH------- 10 LQATGQLADNL......AT---------HE..RIVDGIERGDREEAQR----------------- 11 ----PQYSGDP......TREDIELTHQAHA..RVAAAVLDGDGDAAAEAMREHI----------- 12 --RVSDIEG--......---TVSGTLCEHD..AVLQAIRARDPEAADRAMAEHMRMAGA------ 13 ------KHRTR......TYNARPETAAQHA..ALLDAVLGRDSAAAREAARLHVRTFGGLV---- 14 -----------......-------------..--------------------------------- 15 -----------......-------------..--------------------------------- 16 KHVPHLTKEIC......ENSIYEYI-----..--------------------------------- 17 -----------......-------------..--------------------------------- 18 -----------......-------------..--------------------------------- 19 DEA--------......---NMPQTLQEHK..ALFDAIRHQDGDAAEQAALTM------------ 20 GVFYNRQIMFR......NRSTREALLEQHR..AINAAIQARDGFAARAAVAAHMDFVEVAL---- 21 MRETRKIWLFS......KKTSVQRLYEEHE..RIYNAVAAGNGAQAEAAMLAHLTNVEDV----- 22 ---RDWLRGDV......GEGMSPAMHMDHA..RLVDAIRAGDAATAAE----------------- 23 AVVPDYLHQDYtattphDYLSLIAPLTEGE..HIVEAVQATAEECALLHIHAH------------ 24 AIAPDYLKQDF......TRQTPYAYLSQVA..PLT------------------------------ 25 STAPDYMKQDF......NQITPYSYLTQAA..PLT------------------------------ 26 KLFRNLSLQHL......EG-----------..--------------------------------- 27 -----------......-------------..--------------------------------- 28 -----------......-------------..--------------------------------- 29 -----------......-------------..--------------------------------- 30 -----------......-------------..--------------------------------- 31 -----------......-------------..--------------------------------- 32 -----------......-------------..--------------------------------- 33 -----------......-------------..--------------------------------- 34 -----------......-------------..--------------------------------- 35 -----------......-------------..--------------------------------- 36 -----------......-------------..--------------------------------- 37 -----------......-------------..--------------------------------- 38 -----------......-------------..--------------------------------- 39 -----------......-------------..--------------------------------- 40 -----------......-------------..--------------------------------- 41 -----------......-------------..--------------------------------- 42 -----------......-------------..--------------------------------- 43 -----------......-------------..--------------------------------- 44 -----------......-------------..--------------------------------- 45 -----------......-------------..--------------------------------- 46 -----------......-------------..--------------------------------- 47 -----------......-------------..--------------------------------- 48 -----------......-------------..--------------------------------- 49 -----------......-------------..--------------------------------- 50 -----------......-------------..--------------------------------- 51 -----------......-------------..--------------------------------- 52 -----------......-------------..--------------------------------- 53 -----------......-------------..--------------------------------- 54 -----------......-------------..--------------------------------- 55 -----------......-------------..--------------------------------- 56 -----------......-------------..--------------------------------- 57 -----------......-------------..--------------------------------- 58 -----------......-------------..--------------------------------- 59 -----------......-------------..--------------------------------- 60 -----------......-------------..--------------------------------- 61 -----------......-------------..--------------------------------- 62 -----------......-------------..--------------------------------- 63 -----------......-------------..--------------------------------- 64 -----------......-------------..--------------------------------- 65 -----------......-------------..--------------------------------- 66 -----------......-------------..--------------------------------- 67 MVHEEDYEKWF......SYGRAGESLWQ--..--------------------------------- 68 -----------......-------------..--------------------------------- 69 ALIGPLTAQDV......TDASLYGLLGQ--..--------------------------------- 70 RMVPNLLE---......-------------..--------------------------------- 71 DLVSDLTSEEL......EQGDLYEHLGERHdvRVSEAVQSIEPTVVTRAEADLL----------- 72 --AESRTESLR......QPGRPGRSLAQHR..AILDAVAARQPRQAAAAMRRHVRTV-------- 73 PMWIQLHSHLD......DSLYRKEWLGDHK..QILAALIKKDARAAKLAMWQHLENVKQRLLE-- 74 AMWAQLHSRIL......QNDYHHLWIEDHQ..TILSAIQKKNANEARKAMWQHLENVKVKL---- 75 PYWRKLHEHID......DK-SIESWCEDHD..QILKALIRKDPYAAKLAMWQHLENTKQMLF--- 76 PYWKKLHEHID......SR-TVDNWCDDHD..QILKALIRKDPHAAKLAMWQHLENTKIMLF--- 77 PYWKKLHEHID......SR-TVDNWCDDHD..QILKALIRKDPHAAKLAMWQHLENTKIMLF--- 78 DVGRAVLAGDL......-------------..--------------------------------- 79 -----------......-------------..--------------------------------- 80 -----RYMSFD......HVSPPEMLLRQHL..DIFSALQKRDGDAVERAMTQHLQEISESVRQI- 81 -----RVLRLS......SDLDWDIIISHHK..QIYRLIANKEAEKVRQVMEEHLRLV-------- 82 --DRARRLGLH......ENVSPAVFVAQHR..EIFDAVTEGDVPLARTAMRTHLRAVFD------ 83 --DRARRLGLH......ENVSPAVFVAQHR..EIFDAVTEGDVPLARTAMRTHLRAVFD------ 84 --HFCRILNYT......GDHRAETILREHR..RIFEEVKKKNKEAAKQHVLAHFN---------- 85 --AQQSGLLTA......FGPRREESNEEHR..AIVDAVRKGAEAEAQAAMEFHLKKVE------- 86 -----SAVAWA......ADPSWEREAGEHQ..EILRLALAGDADGAARALHAHIA---------- 87 ----GVAVMHS......HPDRIAHTLAEHE..EILDALRAGDAEAAVAVVGRHVGWFSH------ 88 ----RWYYTPV......ARQRGRQSWIEHR..RLIAAVTERDEQAATRLMREHTEH--------- 89 --EHSFLVSTR......TPGAVEASLPAHR..AVVQAVEAHDPAAAAAAVLAIVEAAEDE----- 90 LYSRREMLPLV......SS--------HRT..RIFEAIMAGKPEEAREASHRHLAFIEDFAR--- 91 LYSRREMLPLV......SS--------HRT..RIFEAIMAGKPEEAREASHRHLAFIEEILLD-- 92 LYSRREMLPLV......SS--------HRT..RIFEAIMAGKPEEAREASHRHLAFIEEILLD-- 93 LYARREMLPLV......ST--------HRT..RIFEAIMAGKPEEAREASHRHLAFIEEIMLD-- 94 LYHRPQQKKQI......DR--------QHA..RIYNAVLQRLPHVAQRAARDHVRTVKKNLHD-- 95 LYHRPQQKKQI......DR--------QHA..RIYNAVLQRLPHVAQRAARDHVRTVKKNLHD-- 96 ----AKIDSQI......PYRERDVTVEYHK..KIYDALAQRDPYKAHYHMYEHLKFVRDKILK-- 97 VR---------......---NLEHSQRQHA..ALVEAVLDGDADGAREIAREH------------ 98 --GGREHALTG......AYDDADPVLTDLR..AINGAVLAGDPAAAAATVEAYLN---------- 99 --GGREHALTG......AYDDADPVLTDLR..AINGAVLAGDPAAAAATVEAYLN---------- 100 ------DLVRH......LNERYVVSNREHK..ELIERIISGDKEGAIEKLKEHLKNVEAE----- 101 ---PAGSPSVR......GRADLVADAHQHT..ALLDALIAGDLDVVRALVGDHF----------- 102 -----RFARWI......DWQSRRLSHEQHL..HITSLLADRKEDECAAFVLAHIQKHFDQIL--- 103 -----RFARWI......DWQSRRLSHEQHL..HITSLLADRKEDECAAFVLAHIQKHFDQIL--- 104 PEARSLALGFY......HKLSALCSEGAHD..QVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR 105 PEARSLALGFY......HKLSALCSEGAHD..QVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR 106 PEARSLALGFY......HKLSALCSEGAH-..--------------------------------- 107 PEARSLALGFY......HKLSALCSEGAHD..QVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR 108 -----------......-------------..--------------------------------- 109 KKHRELTKQFY......LEMQQICLEGNAD..AVVDCIRKHNLRSSTYWKAILER---------- 110 --RLAFHVVDD......PRRLHEPYIARNA..EILSTLESGEREAAARLLAVYLEN--------- 111 ERIREGTWRYL......ETKTGRVVVQGQD..RV------------------------------- 112 ERIKEGSWAYL......EEQTGMTAVYGQD..RI------------------------------- 113 -----------......-------------..--------------------------------- 114 -----------......-------------..--------------------------------- 115 -----------......-------------..---------------------------------