; SAM: prettyalign v3.1b (February 24, 1999) compiled 04/18/00_11:44:15 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ------ Citations (HMMs, SAM) ------ ; A. Krogh et al., Hidden Markov models in computational biology: ; ------------- Citations (SAM, SAM-T99, HMMs) ----------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; -------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 T0096 ; 2 gi|1345956|sp|P09371|FADR_ECOLI_1:239 ; 3 gi|78799|pir||S01288_1:239 ; 4 gi|461601|sp|P06957|PDHR_ECOLI_5:234 ; 5 gi|7688351|emb|CAB89840.1|_5:234 ; 6 gi|2119894|pir||I53482_5:234 ; 7 gi|473782|dbj|BAA05571.1|_5:233 ; 8 gi|1706732|sp|P42608|EXUR_ECOLI_3:226 ; 9 gi|7449871|pir||C65098_8:231 ; 10 gi|1651584|dbj|BAA36034.1|_1:205 ; 11 gi|7531115|sp|Q9X9E0|EXUR_ERWCH_3:227 ; 12 gi|2623054|gb|AAC46002.1|_4:232 ; 13 gi|462490|sp|P33233|LLDR_ECOLI_1:226 ; 14 gi|731090|sp|P39161|UXUR_ECOLI_5:233 ; 15 gi|5881926|emb|CAB55719.1|_5:224 ; 16 gi|1169604|sp|P44705|FADR_HAEIN_6:234 ; 17 gi|882509|gb|AAA69147.1|_21:254 ; 18 gi|1707916|sp|P52072|GLCC_ECOLI_1:234 ; 19 gi|1176201|sp|P45427|YHCK_ECOLI_25:249 ; 20 gi|7449872|pir||A70745_19:235 ; 21 gi|1731210|sp|Q11159|Y494_MYCTU_19:235 ; 22 gi|7414556|emb|CAB86107.1|_6:221 ; 23 gi|7480738|pir||T36777_6:210 ; 24 gi|3915672|sp|P31460|DGOR_ECOLI_4:217 ; 25 gi|6573304|gb|AAF17624.1|_17:227 ; 26 gi|1174929|sp|P44487|UXUR_HAEIN_25:241 ; 27 gi|7480734|pir||T36491_5:209 ; 28 gi|2147828|pir||I40749_12:209 ; 29 gi|6226387|sp|O07792|Y586_MYCTU_4:226 ; 30 gi|1175615|sp|P42239|YCBG_BACSU_13:228 ; 31 gi|7473999|pir||B75340_12:223 ; 32 gi|2829657|sp|P77577|YDFH_ECOLI_9:217 ; 33 gi|1945709|emb|CAB08003.1|_2:209 ; 34 gi|7140835|gb|AAF37157.1|AF047034_2_8:200 ; 35 gi|6840861|gb|AAF28803.1|_8:211 ; 36 gi|3915418|sp|O05494|YDHC_BACSU_6:208 ; 37 gi|6468429|emb|CAB61589.1|_13:234 ; 38 gi|6448717|emb|CAB61276.1|_24:243 ; 39 gi|7481538|pir||T36849_10:223 ; 40 gi|2506556|sp|P54988|NTRA_CHEHE_4:188 ; 41 gi|7481541|pir||T36904_6:201 ; 42 gi|98867|pir||JC1183_5:206 ; 43 gi|7474000|pir||E75471_34:238 ; 44 gi|4056664|gb|AAC98132.1|_33:233 ; 45 gi|2961083|gb|AAC05646.1|_6:170 ; 46 gi|1857431|gb|AAB67744.1|_21:251 ; 47 gi|418524|sp|P32425|YIN1_STRAM_5:206 ; 48 gi|7480729|pir||T34672_67:269 ; 49 gi|7481483|pir||T35007_13:214 ; 50 gi|290543|gb|AAA62046.1|_4:169 ; 51 gi|123755|sp|P12380|HUTC_KLEAE_9:204 ; 52 gi|7480730|pir||T35298_8:196 ; 53 gi|7462965|pir||B72377_9:203 ; 54 gi|6468725|emb|CAB61681.1|_14:214 ; 55 gi|123756|sp|P22773|HUTC_PSEPU_13:187 ; 56 gi|4731015|gb|AAD28343.1|AF102509_1_9:223 ; 57 gi|6523478|emb|CAB62259.1|_3:191 ; 58 gi|4106575|emb|CAA21330.1|_16:188 ; 59 gi|1438110|dbj|BAA12085.1|_1:123 ; 60 gi|421645|pir||S30403_3:192 ; 61 gi|7466601|pir||H65171_4:112 ; 62 gi|5616306|gb|AAD45715.1|AF160811_3_1:136 ; 63 gi|130096|sp|P16684|PHNF_ECOLI_6:173 ; 64 gi|7474001|pir||E75573_38:208 ; 65 gi|4033500|sp|P70790|YTUX_AGRVI_27:167 ; 66 gi|1717743|sp|P39796|TRER_BACSU_7:165 ; 67 gi|1881415|emb|CAA66999.1|_3:95 ; 68 gi|7475928|pir||D69588_22:117 ; 69 gi|7443060|pir||D70044_5:88 ; 70 gi|129347|sp|P13669|FARR_ECOLI_3:89 ; 71 gi|6273661|emb|CAB60175.1|_9:123 ; 72 gi|7470190|pir||S74897_55:169 ; 73 gi|538975|pir||G48652_9:122 ; 74 gi|7481736|pir||T36219_9:122 ; 75 gi|7428913|pir||G69999_5:91 ; 76 gi|3915501|sp|O31761|YMFC_BACSU_6:94 ; 77 gi|7473145|pir||A75353_23:139 ; 78 gi|7473515|pir||C75540_21:173 ; 79 gi|7443062|pir||C70710_19:93 ; 80 gi|7475898|pir||B69780_7:82 ; 81 gi|7649560|emb|CAB89035.1|_25:128 ; 82 gi|7428911|pir||F69750_4:112 ; 83 gi|3915562|sp|O32152|YURK_BACSU_6:77 ; 84 gi|7428910|pir||B65132_28:103 ; 85 gi|7522189|pir||T35391_10:95 ; 86 gi|3916015|sp|P45544|YHFR_ECOLI_6:81 ; 87 gi|7480735|pir||T36493_6:93 ; 88 gi|7443063|pir||D72336_7:89 ; 89 gi|7475900|pir||E69838_11:89 ; 90 gi|3688823|gb|AAC62421.1|_11:83 ; 91 gi|549814|sp|Q01856|YRDX_RHOSH_9:114 ; 92 gi|7481808|pir||T35462_9:124 ; 93 gi|1763080|gb|AAB39643.1|_5:112 ; 94 gi|7480739|pir||T37185_4:75 ; 95 gi|7480737|pir||T36750_20:92 ; 96 gi|7476658|pir||A70555_11:85 ; 97 gi|7444907|pir||F69778_12:79 ; 98 gi|7473653|pir||D75469_14:98 ; 99 gi|6137032|emb|CAB59587.1|_12:198 ; 100 gi|401607|sp|P31453|YIDP_ECOLI_3:155 ; 101 gi|7462964|pir||A72398_3:110 ; 102 gi|3947499|emb|CAA07150.1|_3:70 ; 103 gi|6007837|gb|AAF01064.1|AF189258_3_5:94 ; 104 gi|2127492|pir||S70089_5:87 ; 105 gi|418474|sp|P32133|YIHL_ECOLI_4:80 ; 106 gi|7475897|pir||H69777_24:153 ; 107 gi|6468718|emb|CAB61674.1|_28:124 ; 108 gi|3025167|sp|P76420|YEGW_ECOLI_21:156 ; 109 gi|7481476|pir||T34792_2:61 ; 110 gi|3868868|dbj|BAA34256.1|_11:79 ; 111 gi|6448745|emb|CAB61304.1|_16:170 ; 112 gi|2668604|gb|AAB88607.1|_8:104 ; 113 gi|2496298|sp|P75532|Y101_MYCPN_5:84 ; 114 gi|7444908|pir||G69825_8:81 ; 115 gi|7649566|emb|CAB89055.1|_18:131 10 20 30 40 50 60 | | | | | | 1 MVIKAQSPAGFAEEYIIESIWNNRFPPGTI.LPAERELSELIGVTRTTLREVLQRLARDGWLTIQ 2 MVIKAQSPAGFAEEYIIESIWNNRFPPGTI.LPAERELSELIGVTRTTLREVLQRLARDGWLTIQ 3 MVIKAQSPAGFAEEYIIESIWNNRFPPGTI.LPAERELSELIGVTRTTLREVLQRLARDGWLTIQ 4 -KIRQPKLSDVIEQQLEFLILEGTLRPGEK.LPPERELAKQFDVSRPSLREAIQRLEAKGLLLRR 5 -KIRQPKLSDVIEQQLEFLILEGTLRPGEK.LPPERELAKQFDVSRPSLREAIQRLEAKGLLLRR 6 -KIRQPKLSDVIEQQLEFLILEGTLRPGEK.LPPERELAKQFDVSRPSLREAIQRLEAKGLLLRR 7 -KIRQPKLSDVIEQQLEFLILEGTLRPGEK.LPPERELAKQFDVSRPSLREAIQRLEAKGLLLRR 8 -ITEPRRLYQQLAADLKERIEQGVYLVGDK.LPAERFIADEKNVSRTVVREAIIMLEVEGYVEVR 9 -ITEPRRLYQQLAADLKERIEQGVYLVGDK.LPAERFIADEKNVSRTVVREAIIMLEVEGYVEVR 10 MVIKAQSPAGFAEEYIIESIWNNRFPPGTI.LPAERELSELIGVTRTTLREVLQRLARDGWLTIQ 11 -LTESRRLYQQLAAELKQRIENGVYPVGDK.LPAERNISEEMNVSRTVVREAIIMLEVEGYVEVR 12 QKIESEKLASAVVRQIENLIVEGVLRPGER.LPSERELSERLAVSRPSLREAVAELQQEGLLTTR 13 MIVLPRRLSDEVADRVRALIDEKNLEAGMK.LPAERQLAMQLGVSRNSLREALAKLVSEGVLLSR 14 --TSAQRPYQEVGAMIRDLIIKTPYNPGER.LPPEREIAEMLDVTRTVVREALIMLEIKGLVEVR 15 -QRRRPPLAAAVVQSLATAIVLGQYPPGTA.LPSAGELCEEYEVSRTVIREATTTLAEKGLVATR 16 DILKAQSPAALAEEYIVKSIWQDVFPAGSN.LPSERDLADKIGVTRTTLREVLQRLARDGWLTIQ 17 MKDERRPICEVVAESIERLIIDGVLKVGQP.LPSERRLCEKLGFSRSALREGLTVLRGRGIIETA 18 MKDERRPICEVVAESIERLIIDGVLKVGQP.LPSERRLCEKLGFSRSALREGLTVLRGRGIIETA 19 RPLARKKLSEMVEEELEQMIRRREFGEGEQ.LPSERELMAFFNVGRPSVREALAALKRKGLVQIN 20 QPPDRQRVDERIATTIADAILDGVFPPGST.LPPERDLAERLGVNRTSLRQGLARLQQMGLIEVR 21 QPPDRQRVDERIATTIADAILDGVFPPGST.LPPERDLAERLGVNRTSLRQGLARLQQMGLIEVR 22 RPMTKQRLYEQVLERLRQYVADGGLRAGDR.LPPERDLAQRLGVSRASVKQAIVVLEVQGLVEAR 23 --PRRSALSEQVIAALRQQIASGEWPVGSR.IPTEPELVEQLGVARNTVREAVRALAHNGLLDIR 24 ------NKTDRIVITLGKQIVHGKYVPGSP.LPAEAELCEEFATSRNIIREVFRSLMAKRLIEMK 25 -PQPKKLPLELVFEELRNLILSGRFAAGAK.LPSEAKLAAKYGVSRPIVREALRSLQILGLTETR 26 -------TYTRIGQLLKQDISQGIYSIGDK.LPTEREISEKFGVSRTIVREAMVMLEVEKLVEVK 27 --VKQPPAADRVYTHVKQGVLERRYEGGTL.L-TEGELAEAVGVSRTPVREALLRLEAEGLIRLY 28 --------AAKLYEHLKEMAVSYHFRPGER.I-NEVELAAQLKVSRTPLREALNRLTTEGFLTTT 29 QPVTRRSVPEEVFEQIATDVLTGEMPPGEA.LPSERRLAELLGVSRPAVREALKRLSAAGLVEVR 30 --VNRKTLAKQVIERIVHLLSSGQLRAGDK.LPTEMELMDILHVSRPVLREALSSLETLGVITRK 31 -LQKRRSIGADIAEKLQQLINDGTFKPGDR.LPGQRELAQQFGTSLAGVREAISVLSAAGLVDAR 32 ---PTQPVNQQIYRILRRDIVHCLIAPGTP.L-SEKEVSVRFNVSRQPVREAFIKLAENGLIQIR 33 -------------------IKNGELKPGDK.LDSVQALAESFQVSRSAVREALSALKAMGLVEMK 34 ------SLREQIREHIVEGIVSGRWQPGER.I-VERRIATELEVSQTPVREALRELESLRLIESA 35 ----SENVGRWLRDEIENSILSNEFSPGER.L-DETVLATRFGVSRTPVREALMQLDAIGLIEIR 36 -LDKPTPYYLQFYNQLKKMIFNGTFKPGER.I-NETQLAKSFGVSRSPIREAMRLLEKDGLLKAD 37 -----PTMQQRVVDELGRRIVGGAWEPGVP.LPVEDALAAEIGVSRGVLREAVKALAAKGMLHVR 38 -PVVRESSVSEVAKRLLDHLSAGDIRPGTR.LPAERQLAEALGVARSSVRGALSALDVLGIIEIR 39 RPVRAGNGFEEALEQILQVVRLGLVAAGER.LPAERELAERLGISRVTLREVLRVLQDQGLVQAR 40 ---------------------SYHFRPGER.I-NEVELAAQLKVSRTPLREALNRLTTEGFLTTT 41 --TPIPSRTQYVLEEIKRRILTGRLTPGQA.L-VETDLAAQFGVSKTPVREALKTLAGTGLVVMS 42 ---NGRTNRRDIYLKLRQMVLTLELAPGAA.L-SENELAASMGVSRTPVRESLILLAQEGLVQVF 43 --QRPGLVREGVYQHLRRAVLDGEIAPGER.L-GEVELGQHLGVSRTPIREAIMRLTQDGLLVAE 44 ----RGSARDQLYEMLKEKILRLELEPGTK.I-SEKEIAQQLHISRTPVREAFLKLAQEELLDII 45 -PLIKRSLVDQALEQLRWRISEGRWAIGER.LPTEPELAAELGISRNTVREAMRVLAFSGLIEIR 46 --PRTTKRGDQVAELIKGWINDGRVRPGKR.LNKEAELQQMFNVSRGSMRDALKALEVQGLVSLS 47 ---NGRTNRRDIYLKLRQMVLTLELAPGAA.L-SENELAASMGVSRTPVRESLILLAQEGLVQVF 48 -LVQRSSVRGQILDALRSALVTGELRPGEV.Y-SAPVLGERFGVSATPVREAMQQLALEGAVEVV 49 RLERPGPLRDRVYEALLELITTRALQPGQH.L-VESELAGHLGVSRQPVREALQRLNTEGWVDLR 50 ------NKTDRIVITLGKQIVHGKYVPGSP.LPAEAELCEEFATSRNIIREVFRSLMAKRLIEMK 51 ---APAPFYEKVKQAISEKIHSGVWRPHDR.IPSEAELVAQFGFSRMTINRALRELTDEGLLVRL 52 ------SLREQIREHILEGIISGRWQPGER.I-VERRIATELEVSQTPVREALRELESLRLIESA 53 -------VRTKVYNLLKEMILNHELKLGEK.L-NVRELSEKLGISFTPVRDALLQLATEGLVKVV 54 -LLGRTSTAERVSDILRSRIAEGYFPPGTR.L-SEDSIGGALGVSRNTLRESFRLLTHERLLVHE 55 MGEGPAPLYARVKQMIIQQIDNGSWPPHHR.VPSESELVNELGFSRMTINRALRELTADGLLVRM 56 -PEAPVGRADEIVQRITEAIHLGLLDDGER.LPVEVDLAAQFGVAPMTVREALATLRELELVETR 57 KIERSAPPYMQVVTHFRTRIMSGELSPGDA.LPTDRGLAEEWGVSRATAQKALTVLKTEGLIEAV 58 --DIPAPIYQRVKLAIIRQIRTGTWQPHQR.VPSESELVTELGVSRMTINRALRELTNEGFLIRM 59 MVIKAKSPAGFAEKYIIESIWNGRFPPGSI.LPAERELSELIGVTRTTLREVLQRLARDGWLTIQ 60 KIERPLPPYMQVIAHIRDQIDSGELRAGDL.IPSDRNIAQEWGISRATAQKVITALKAQGLVEAV 61 ------NKTDRIVITLGKQIVHGKYVPGSP.LPAEAELCEEFATSRNIIREVFRSLMAKRLIEMK 62 MKEKTLPKYLQLKQEILSWIISGQMKPDEK.IPTEHEIANQFQLSRHTVRQALGELEKEGWLYKI 63 HPTSYPTRYQEIAAKLEQELRQ-HYRCGDY.LPAEQQLAARFEVNRHTLRRAIDQLVEKGWVQRR 64 DPADAAPAYVQLAQGLRRRIESGELSAGTA.LPAERELAARLGVSRVTLRQGLGLLEAEGLLRRR 65 --VSSAGRVSAAYHAIRNAIRTNVFPPGYQ.A-AEIEIARQLGMSRTPVHEAMARLQEDGLVRIL 66 ---------ITIYKDIAQQIEGGRWKAEEI.LPSEHELTAQYGTSRETVRKALHMLAQNGYIQKI 67 ------PKYAQVKEEISSWINQGKILPDQK.IPTENELMQQFGVSRHTIRKAIGDLVSQGLLYSV 68 ---DMLPKYAQVKEEISSWINQGKILPDQK.IPTENELMQQFGVSRHTIRKAIGDLVSQGLLYSV 69 -KQSPIPIYYQIMEQLKTQIKNGELQPDMP.LPSEREYAEQFGISRMTVRQALSNLVNEGLLYRL 70 ----HKPLYRQIADRIREQIARGELKPGDA.LPTESALQTEFGVSRVTVRQALRQLVEQQILESI 71 -RSSPVPLYFQLSQQLEAAIEHGALTPGSL.LGNEIELAARLGLSRPTVRQAIQSLVDKGLLVRR 72 ---SEIPASKQLFDQIRFAIASRQYHPGHR.LPSTRQLAMMTGLHRNTISKVYQNLEDAGLVESI 73 ---RSGPRYVQIADEIVQQIRAGVLKPGDM.VPSESELVDRYGVSGGTIRKAMVEVRASGLVETR 74 ---RSGPRYVQIADEIVQQIRAGVLKPGDM.VPSESELVDRYGVSGGTIRKAMVEVRASGLVETR 75 DPRSSTPIYEQIIQQMKELCLKGIMKPGDK.LPSVRELATIIIANPNTVSKAYKELEREGIIETL 76 ---DNRHLYLKVIERIKEDIKNGIYTEKEK.LPSEFELSKKLGVSRATLREALRILEEEHVIIRR 77 -PETGEALHTRTERTLRAAIGQGRLPQGTR.LPGHRALAAALGVSRNTLVDALAQLEIEGYVEVR 78 -PEARMAKYPLIKTTLKDRLLGGHYPEGLP.LPSEPQLAREFEVSRMTARRAIDELEREGYVYRV 79 ----SVPASTQLAEALKAQIIQQRLPRGGR.LPSERELIDRSGLSRVTVRAAVGMLQRQGWLVRR 80 KKMKKLPKYRQIVHFIKEKIGNGEWPIGSK.IPSQRTLAKDFQVNRSTVITALEELMADGLIEGT 81 -RSSPVPLYYQLARQLEAAIEHGVLAPGNL.LGNEVDLSVRLGLSRPTVRQAIQSLVDKGLLVRR 82 -------LYSVIKFKIIELIKSGKYQANDQ.LPTESEFCEQYDVSRTTVRLALQQLELEGYIKRI 83 ---SSTPLYIQLKQIITDDIKKGVYSPTAK.LPTENELCTKYNVSRITVRKAILDLVEEGYLIRQ 84 -RYSHQLLYATVRQRLLDDIAQGVYQAGQQ.IPTENELCTQYNVSRITIRKAISDLVADGVLIRW 85 --VTRSTLRQQIADALRDEVLAGRLQPGQE.F-TVKEIAEQYGVSATPVREALVDLSAQGLLDAD 86 -RYSHQLLYATVRQRLLDDIAQGVYQAGQQ.IPTENELCTQYNVSRITIRKAISDLVADGVLIRW 87 DKTDTRPLHEQVAGALRRAIAEGECAPGDR.LPSARDLSEALDVNVNTVLRALRGLRDEGLLEFR 88 -FHSSKPIYEQIKERIKLLILSGKLKEGEF.VPSIRSLAEDLGVNLNTVARAYRELVQEGVLEVR 89 --KSDVPLHRQIEQYMKDKILHGEWAVGTK.IPSQRTLADMFQVNRSTVTAAIDELTSQGLLEGR 90 ---SRTPIYHQIEEQIKALIVSGHVSAGTP.LPSIRALSKDLACSVITTRRAYQNLEQQGYIKTS 91 ---TARLKYLGIVDALEADIRAGRVTPGER.LPPQRAIAEALGVDLTTVTRALNEAQRRGLVSAQ 92 ---RSGPRYVQVADEIVQQIRAGVLKPGDM.VPSESEMVDRYGVSGGTIRKAMVEVRASGLVETR 93 --PGDIPQYLLIKAQLQARIQSGALKSGDK.LPSERELCAIFNTTRITIRESLAQLESSGLIWRA 94 -IQRPGALYQQVAAAIRDAILSGEFAPESL.LPSEAQLMARYQVSRPTVRNAIAALRAEGLIDVR 95 -VDDGAPPYEQVRAQISEQARSGALPVGYR.LPTVRGLAESLGLAANTVAKAYRALEADGVIETR 96 -VKAGKPLFDQLRTQVIDGVRAGALPPGTR.LPTVRDLAGQLGVAANTVARAYRELESAAIVETR 97 ----DIPLYQQLYRYFKENMHRGRIQKGMK.LPSKRLLANQLSISQTTVERAYEQLAAEGYIVSK 98 ---GPSPIHLQLAAQLREAALAGQLLPGSL.LPGTRTLARDLGVTRGVVEAAYALLSADGTLQGE 99 --LKRERVRDAVLELIEDR------RPGDA.IPSERTLCAELGVSRPTLRAAIDELVVAGLLVRE 100 --------YKSIAERLRIRLNSADFTLNSL.LPGEKKLAEEFAVSRMTIRKAIDLLVAWGLVVRR 101 -----------------DEIKSGKYKHGDK.LPTEKELMERFNASRETVRKALERLVVKNLVIRK 102 ------PKTQAAYVIISGWIATGRYGPGDK.LPSERAMCEDLGIGRTALRQVLAKLVAEGILEVH 103 ----EVSLTAQIQRFIKNEISEGVLHPGTR.LPSSRALADDLDVSRSVVVEAYGQLVAEGYLEAT 104 --------REDIAGQLRERILAGDLKPGER.LPSTRELVAQHGGSRTTANQALRLLAAEGLVALR 105 ----NQSTVENAKEKLDRWLKDGITTPGGK.LPSERELGELLGIKRMTLRQALLNLEAESKIFRK 106 ----EKPIYKALAGQLEQDILNGVLLPGTK.LPPQRELADYLDLNVSTISKAFKVCELKGLLSAT 107 -GTRRPPAYRALADGIRLLVLEGRVPVAAR.LPAERELALALTVSRTTVAAAYEALRAEGFLESR 108 ----NTPLYIKFAETVKNAVRSGVLEHGNI.LPGERDLSQLTGVSRITVRKAMQALEEEGVVTRS 109 ------------AEIISKRIADGTYPPGTR.VPGIVELSAEFGIAASTAQKALAHLRGTGEVRTE 110 ----DKPKYVQISQKIKVIIERGIINDGEK.LPSIRKLSELLNVNKDTVINAYRKLEEEGYAIQK 111 ---PRAERARALADALRQQITDDAFADG-V.LPDERDLGRRFGASRNAVRDALALLREEGLITRR 112 ----------QLVQRILADIQVGKLADGQRkLPAEPVLMERYQVTRYTLRQALKQLSNMGYTYQM 113 --KEQAKKGQIIYRYILLKIQSFKWPAGTR.IFSERQLEIRFASSRSLIRTILNTLLGKDLIRHT 114 DKKSKTPLYEQLYTFFKQEISHARITKGTR.LPSKRRLSSLLDVSTATIERAYEQLTAEGYVKSK 115 ----GPGLRRGLTDALREAVRTGRLGPGTR.LPSSRVLAADLGIARNTVADAYADLVAEGWLTAR 70 80 90 100 110 120 | | | | | | 1 HG..KPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAF..RQHPDKAQ 2 HG..KPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAF..RQHPDKAQ 3 HG..KPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAF..RQHPDKAQ 4 QG..GGTFVQSSLWQSFSDPLVELL----SDHPESQYDLLETRHALEGIAAYYAAl.RSTDEDKE 5 QG..GGTFVQSSLWQSFSDPLVELL----SDHPESQFDLLETRHALEGIAAYYAAl.RSTDEDKD 6 QG..GGTFVQSSLWQSFSDPLVELL----SDHPESQYDLLETRHALEGIAAYYAAl.CSTDEDKE 7 QG..GGTFVQSSLWQSFSDPLVELL----SDHPESQYDLLETRHALEGIAAYYAAl.RSTDEDKE 8 KG..SGIHVV-----SNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAAt.QVTKQDIM 9 KG..SGIHVV-----SNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAAt.QVTKQDIM 10 HG..KPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAF..RQHPDKAQ 11 KG..SGIHVISNQQRHLLAANGSDA----DFLTAGPFELLQARQLIESNIAEFAAt.QVTRQDII 12 AG..SGIFVAEVLGSAFSPALIRLF----ARNDQAVFDYLAFRRDLEGMAAERAAk.MGSDTDLK 13 RG..GGTFIRWRHDTWSEQNIVQPLKTLMADDPDYSFDILEARYAIEASTAWHAAm.RATPGDKE 14 RG..AGIYVLDNSGSQNTDSPDAN-----VCNDAGPFELLQARQLLESNIAEFAAl.QATREDIV 15 QG..WGTVVLGQDQWSLLDPLVLDALFQRADRLVYLDNLIEIRTTLECAMAARAAg.RIDEEQSA 16 HG..KPTKVNNIWDAAGPNIIETLIALDMQSAPLIIDNMLSLRSKMSESYIYEAV..KNSPQKST 17 QG..RDSRVARLNRVQDTSPLIHLF----STQPRTLYDLLDVRALLEGESARLAAt.LGTQADFV 18 QG..RDSRVARLNRVQDTSPLIHLF----STQPRTLYDLLDVRALLEGESARLAAt.LGTQADFV 19 NG..ERARVSRPSADTIIGELSGMA-KDFLSHPGGIAHFEQLRLFFESSLVRYAA..EHATDEQI 20 HG..SGSVVRDPEGLTHPAVVEALVR---KLGPDFLVELLEIRAALGPLIGRLAAa.RSTPEDAE 21 HG..SGSVVRDPEGLTHPAVVEALVR---KLGPDFLVELLEIRAALGPLIGRLAAa.RSTPEDAE 22 HG..GGTYLVR-------DSLDVEPVEKMVERRRRLPDVLEAREALETKLAELAAe.RRTEDDLA 23 QG..SGTYVVATSELAG--------VMQRRFADADPRDIAELRSTLESAAARLAAe.RRTEKDLK 24 RY..RGAFVAPRNQWNYLDTDVLQWVLENDYDPRLISAMSEVRNLVEPAIARCGAe.RATSSDLA 25 TG..SGTYVLAAAGDGDI-----------RYGNYSARDLMEARAFVEVSAAGWAAl.RRTDDELS 26 KG..SGVYVVRTPESIHMEHS--------DLPDVGPFELLQARQLLESSIAEFAAl.QATKKDIL 27 PK..KGALVL-------------------PVSAQEIADVVETRLLVEEHAARKAV..PAPPGLVE 28 AN..KGFFAR-------------------VLEANTLFDLYELRAFLEQSAVRLACq.RATDQEIA 29 QG..DVTTVRDFRRHAGLDLLPRLLFRNGELDISVVRSILEARLRNFPKVAELAA..ERNEPELA 30 TR..GGTYFNDKIGMQPFSVMLALA-------TDNLPAIIEARMALELGLVTIAAe.KINEEELQ 31 PG..RGTVVRS----VGGAVPTFDGWLGAVGDEQEFEELMQARRMLEAFTIAQAVa.RATPAQVS 32 PQ..RGSYVN-------------------KISMAQVRNGSFIRQAIECAVARRAAs.MITESQCY 33 QG..EGTYLKEFELNQISQPLSAAL----LMKKEDVKQLLEVRKLLEIGVASLAAe.KRTEADLE 34 PN..KGVRVR-------------------NLTAADLEESYPVRAGLEAIAAELAA..ETLAESCE 35 PR..RGAIVI-------------------DPGPHRVYEMFEVMAELEGLAGSLAAr.RLDKTSRE 36 DR..NGFSIT-------------------SLTAKDVDEIYKIRIPLEQLAVELVId.EADEEELT 37 PR..TGTRVLSPEHWNHLDRDVLRW-KQAGDATALLRDTSELRRIVEPEAARLAAe.RAGSEDVR 38 PG..SGSYVRE----GTSEFLPRAINWGLMLGQRRTRDLVEVRTHMEGVSARLAAe.RATDADVA 39 RGryGGTFVLPRADAGGEDELRR------RVAGVDIEDVLRFREVLEAGAAGLCAahGLAGARAA 40 AN..KGFFAR-------------------VLEANTLFDLYELRAFLEQSAVRLACq.RATDQEIA 41 QY..KGVTVR-------------------MVDADMAREVYDVRLLLEPEALRRAVr.--REASLD 42 PK..IGSFVS-------------------RVDPARVADAQFLREAVELGSLDALPa.ELDPAVVG 43 AN..KGARVR-------------------LLSAAEARDTYAVREELDGLAAALAAa.QHTPDDAH 44 PQ..SGTIVS-------------------RINLEHVEEGRFIPEVVEKEVAVLACt.KLRQDHLF 45 QG..DGSYLR-----SMTDPLGAMR----ALSHCTLEQAQETRQILEVEAVGLAAv.RRTEADLT 46 TGpeGGATITRVPLARAFQALQNYL----FFENVTLEELYAVRRTLEPIVAAGAVa.HLTDADFE 47 PK..IGSFVS-------------------RVDPARVADAQFLREAVELGSLDALPa.ELDPAVVG 48 PN..RGFRVL-------------------ERGDRELAELAEVRALIEVPVWLRLAr.TVPAEHWA 49 PA..QGAFVH-------------------EPTEEEADQLLTVRTLLEAEAARLAAa.NASSAGIA 50 RY..RGXFVAPRNQWNYLDTDVLQWVLENDYDPRLISAMSEVRNLVEPAIAVAXAe.RATSSDLA 51 QG..VGTFVAEPKGQSAL-------------------------FEVRSIAAEIVA..RHHQHRCE 52 PN..KGVRVR-------------------NLTAADLEESYPVRAGLEAIAAELAA..DRLALDCS 53 PR..VGFFVT-------------------DVDEKFIRETIETRIMMEVFCLENYFdkIAGSEELL 54 LN..RGVFVR-------------------VLTVEDVEDIYRTRSLVECAVVRGLGepPYPLDGLA 55 QG..VGTFVAEPKGRSAL-------------------------FEVNNIADEIAA..RGHQHSCQ 56 RGrsGGSFVRRPAGPPVEKLTARLA----AMSASDLRDLFDEHTAIAGQAARLAAe.RAAPSTVR 57 QG..SGTRVR----------------QSAPLHHNGHDRAVSVRRTGRIYAEGEYA..RITSASLE 58 QG..VGTFVAEAKAHSAL-------------------------LEVHNIADEIAA..RGHRHSSQ 59 HG..KPTKVNQFMETSGLHILDTLMTLDVDNATNIVEDLLAARTNISPIFMRYAF..KANKEN-- 60 QG..SGTRVRAAAD---------------HLHRSGRDRAASVRRTGRIYTAGEYA..RIVSAELA 61 RY..RGAFVAPRNQWNYLDTDVLQWVLENDYDPRLISAMSEVRNLVEPAIARW--..-------- 62 QG..SGTFVSRPKPKEQVDTKTIGIVTTYISDYIFPHIVRGAEETLREKGYRLLL..ASTNNDKQ 63 QG..VGVLVLMRPFDYPLNAQARFS-------------------------QNLLD..QGSHPTSE 64 RG..SGTFVAGTPHTSRQLGLLSSF-------------SDEVRAQGGVPGARVLSf.TQGRPTPQ 65 PK..KGIIIC-------------------ALSPADIEEIYEVTIALEGAAASRLA..MIDAPVKA 66 RG..KGSVVLN--------------REKMQFPVSGLVSFKELAQTLGKETKTTVH..KFGLEPPS 67 QG..GGTFVASRSAKSALHSNKTIGVLTTYISDYIFP------------------..-------- 68 QG..GGTFVASRSAKSALHSNKTIGVLTTYISDYIFP------------------..-------- 69 KG..RGTFVSKPKMEQALQGLTS--------------------------------..-------- 70 QG..SGTYVKE------------------ERVNYDIFQLTSFDEKLS--------..-------- 71 RG..VGTQVV-------------------HSKVRRPLELSSLYDDLEAAGQRPAT..KVLVNTVV 72 AG..SGIYVKAPSTEEGM-----------ILDGPLFREYPEASQLIQKTIDELLGq.GLNLSQVK 73 HG..KGSIVKDRPPVRHRSSDRFRRSLRQGGKAAYLAESAQSGATAKVSVLYIGP..-------- 74 HG..KGSIVKDRPPVRHRSSDRFRRSLRQGGKAAYLAESAQSGATAKVSVLYIGP..-------- 75 RG..RGTYISENAKTTLVEGKMTMI------------------------------..-------- 76 HG..VGTFVHSK-----------------PLFLSGIEQLNSVTKMIE--------..-------- 77 GR..SGTRVCVPPDEAAPPSPPPLP------------------------------..-------- 78 QG..AGTF---------------------PTGKRFRQGVFRVRPFKE------WA..RHPDHRTT 79 QG..LGTFVADPVEQEL--------------------------------------..-------- 80 MG..KGTVVINNTW-----------------------------------------..-------- 81 RG..VGTQVV-------------------HSQVRRPLELSSLYDDLEAAGQDPGT..RVVRNED- 82 QG..KGTFVSAAKIQTPIPHKITSFAEQM----RGLR--------SESKVLELVV..IPADHSIA 83 QG..KGTFVKSPK------------------------------------------..-------- 84 QG..KGTFVQSQKVE----------------------------------------..-------- 85 HH..RGFRVH-------------------EYSVDDFRGMIEARSLV---------..-------- 86 QG..KGTFVQSQKVE----------------------------------------..-------- 87 RG..RGVTVAE-----------------------GARPHSELQIRVREL------..-------- 88 RG..EGYVVSKVNVEKIRTQLE---------------------------------..-------- 89 KG..GGTKVVNSTWSVLTA------------------------------------..-------- 90 QG..RGTFVAEIDE-----------------------------------------..-------- 91 VG..RGTFVRDEPAGDEGGGTPLDLSMNIPPQPAEP----DLRRILPQGIA----..-------- 92 HG..KGSIVKDRPPVRHRSSDRFRRSLRQGGKAAYLAE-----------------s.EQSGATAK 93 DR..RGWFVTPERLWLD-------PT-----------------------------..-------- 94 HG..KGSFVRS--------------------------------------------..-------- 95 GR..NGTFVAA-------------------A------------------------..-------- 96 GR..FGTFISRFDP-----------------------------------------..-------- 97 PR..SGWFAD---------------------------------------------..-------- 98 VG..RGTRVSRGVGRTAQAAAPSPAW-----------------------------..-------- 99 HG..RGMFVAAEKITQ---------------------ELLSDRRAFSLPQAAGAW..T---SRLL 100 HG..SGTYLVRKDVLHQTASLTGLV---------------EVLKRQGKTVTSQVL..------IF 101 PG..LGTFVNIEKKNKVVGILVQQ-----ITSYIFPYIALGAEEVLFANGYKMLL..GNASEDPH 102 QR..SAYRVPSG-------------------------------------------..-------- 103 RG..AGTRVGPHLA----EPAVVPALLDAGSGPETR-------------------..-------- 104 EK..SAAVVLAPEDAGKTPESRL--------------------------------..-------A 105 DR..KGWFVTQPRFNYSP-----------E-------------------------..-------- 106 VG..SGTFVS----------------YDALSNAYLLEDTKPTH-LIE-----MGAi.LPDHASYE 107 RG..AGSWTAVPAGNPL---------------PARGLEPLPPEALGSVIDL----..-------- 108 RG..YGTQINNIFEYSLK----------------------EARGFSQQVVLRGKK..PDTLWVNK 109 LG..LGTFVA---------------------------------------------..-------- 110 IG..SGTYAKK--------------------------------------------..-------- 111 RG..VGTTVLLPKYAHGLDRLTGLA----EELTGRGTVTNEVRVAVEVPALPAAIas--R----- 112 HG..IGTFVRQQQTNNSI-----------ALQHDGGLSEAAARAGLKLATKKAVM..-------- 113 KGn.AGYFVAKNAGFSFFH------------------------------------..-------- 114 PK..IGWFAAEV-------------------------------------------..-------- 115 QG..SGTRVADRVAAPPAEASARRP-----------REPARPLHDLRPGSPDLAS..FPRVEWLR 130 140 150 160 170 180 | | | | | | 1 EVLATANEVA........DHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFAN 2 EVLATANEVA........DHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFAN 3 EVLATANEVA........DHADAFAELDYTIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFAN 4 RIRELHHAIElaqqs...GDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQNVRQNFEL 5 RIRELHHAIKlaqes...GDLDAESEAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQNVRQNFEL 6 RIRELHHAIElaqqs...GDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQNVRQNFEL 7 RIRELHHAIElaqqs...GDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQNVRQNFEL 8 KLMAIQEQARg.......EQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQR-------SHN 9 KLMAIQEQARg.......EQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQR-------SHN 10 EVLATANEVA........DHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFAN 11 QLMEIQENARq.......EDRFRDSEWDLKFHVQVALATQNSAMATIVEKMWSQR-------IHN 12 VIDAILTRMEtahgk...RNPADEAALDAQFHMAIVEASHNIIMLHMMRAMFDLL--------SE 13 KIQLCFEATLs.......EDPDIASQADVRFHLAIAEASHNIVLLQTMRGFFDVLQSSVKHSRQR 14 KMRQALQLEErelas...SAPGSSESGDMQFHLAIAEATHNSMLVELFRQSWQWR-------ENN 15 ALSAKLDELAgli.....DDPEAYSRADIEFHEIIHHASRDAFGRAIVSSIQGKAVRS------- 16 ALFAELEQLQ........NTAQDYTEFDYQLFRQFTVVANKPFYRLIFNSLKGVYQRIGLLFFKE 17 VITRCYEKMLaasennkeISLIEHAQLDHAFHLAICQASHNQVLVFTLQSLTDLMFNSVFASVNN 18 VITRCYEKMLaasennkeISLIEHAQLDHAFHLAICQASHNQVLVFTLQSLTDLMFNSVFASVNN 19 DLLAKALEINsqsl....DNNAAFIRSDVDFHRVLAEIPGNPIFMAIHVALLDWL------IAAR 20 ALCAALEVVQqa......DTAAARQAADLAYFRVLIHSTRNRALGLLYRWVEHAF---------- 21 ALCAALEVVQqa......DTAAARQAADLAYFRVLIHSTRNRALGLLYRWVEHAF---------- 22 AMRSALAVMAeei.....DRDGHGVEGDRLFHAAVTAAAHSSLLAEFMRSIAHQI---------- 23 QIDGLLLRREeawes...GDAEAFVSADATFHLAVVAASHNNVMTAMYADLGEVM---------- 24 QIESALNEMIann.....QDREAFNEADIRYHEAVLQSVHNPVLQQLSIAISSLQRAVFERTWMG 25 RLLHLCDRMEqe......EDTGAWVRLDSDFHGLIAEASKNAVFRDIVDDVREAM---------- 26 NLKQILNREKell.....TQNQDDYSADKDFHLALAEITQNDVLVKLQEQLWQYR-------FNS 27 RLEELLARQQeqaaa...GDFAAASVTDRCFHAEIVRSGGNEILSRLYDQLRDRQLRM------- 28 VLRDFLLEQDesge....ISAGEMLKLDEEFHFRLVGLSQNEELLKTVRSISERI---------- 29 ELLQDSLRALdte.....EDPIVWQRHTLDFWDHVVDSAGSIVDRLMYNAFRAAYEPTLAALTTT 30 RLQKTIDDIAn.......STDNHYGEADKEFHRIIALSANNPVVEGMIQSLLITH---------- 31 DLRGAVEAMRavm.....GSAGAYAEADMQLHLLLSEVAGNRVVTRLMRAIQRPLMEQLRRSIAH 32 QLEQNLHQQRiaier...KQLDDFFELDDNFHQLLTQIADCQLAWDTIENLKATVDRV------- 33 RIQDALKEMGsie.....ADGELGEKADFAFHLALADASQNELLKHLMNHVSSLL-------LET 34 ALEPHVAALYeadqa...QDGTGQVRHTVGFHRELVRAAGNSVLLHTWEGLGIEV---------- 35 AITATHGRCEksaaa...GDSDAYYYDNEEFHKAIYAAGRSDFLEEQCLQLHRRL---------- 36 ILEKQLEETEkaihng..TEDTEIIRLNQKFHELLVDFSHNRHLKNLLEHVNDLI---------- 37 VLYDALNAMEaaaar...PGRRGYVEADIAFHRALLDAGGNRLLGSLGRAVEIAL---------- 38 RLEEHLQHMRdag.....GDVTAFIDADIAFHLETARIARNTVLSDILHSIRALLQVWME----- 39 RLRDALAGTRd.......APLAQYRRLDTMLHLTLAELCGSPALAAQYAAVRATLNDLLDCIPLL 40 VLRDFLLEQDesge....ISAGEMLKLDEEFHFRLVGLSQNEELLKTVRSISERI---------- 41 AAREALNRADra......TDTAERSLANREFHRALYVPCGNPLLGRMLDEVRDQAALV------- 42 ELRDNLVRQGrkd.....LDLEEFFGLDEAFHQGLMRLSGHGNVWTTVAAAQGHL---------- 43 ALSAALRALNavqg....EDYREQTRLDLAFHRAITHAAHNAALTDLARNLEQRVALI------- 44 EMEKNIAMQElcaek...GNFLELFELDEKFHQLIYDGCRMSRSWKMVQSLNSHFNRL------- 45 ALHEALKASAvlyh....GDLEAYISADLLFHKRLVDAAHNPALSELYQYFSA------------ 46 ALERSISVCEpfvagh..EQALDQRCEDIHFHDVLAAAHPNAFLRCLCRIINQMLHSL------- 47 ELRDNLVRQGrkd.....LDLEEFFGLDEAFHQGLMRLSGHGNVWTTVAAAKGHL---------- 48 ELRPLAEGTVraass...GCPATYAEADRAFHRAALALAGNEQLVRIAGDVHRRAQWP------- 49 ALEALCEEGEravaa...EDVDAAVACNARFHGKVMELAGNAVLAELAAQVDRRV---------- 50 QIESALNEMIann.....QDREAFNEADIRYHEAVLQSVHNPVLQQLSIAI-------------- 51 VLLLEETRADhiq.....ATALSVPE------------GTRIFHSLMVHYENEVPVQIEDRCVNA 52 ALEPHVAALYeadrv...SDGTGQVRHTVGFHRELVRAAGNSVLLHTWEGLGIEV---------- 53 EIKGEIDDVEks......AKREIFDDSDERLHKLFIRASGNELIISLYEKIWDRI---------- 54 EAVEDGRRSAre......GDWKGVGTANIHFHRELVALAGSERTDELMRSVFAEL---------- 55 VITLTEEAAG........SERALALD---------MREGQRVFHSLIVHFENGVPVQIEDRYVNA 56 RLFALTDQLDta......TSLRDRIRADSRFHIQVAVAAQSARLARREANLQAEVSGL------- 57 PAPADVAEALgie.....EGAPAIRR------IRVTYNASDVALSMSTSWLDGALSSTAPALVST 58 VLHLEARPASp.......EEAIALG----------IQPGQQLFYSQIVHYENDFPVQVENRCVNP 59 ----------........----------------------------------------------- 60 PAPADVAEVLsvq.....EGAAVIRR------IRITYNAENQPISASTSWYDGNLAAAAPKLLKT 61 ----------........----------------------------------------------- 62 REKEQLEEMIr.......----------------------------------------------- 63 KLLSVLRPAS........GHVADALGITE---------GENVIHLRTLRRVNGVALCLIDHYFAD 64 EALSLGLT--........-------------------AAEQVYRLRRLRTSDGDPLAVEDSTLPA 65 EVVALLRDATeam9alerNDLPGWAAADERFHETLVA---------------------------- 66 ELIQKQLRANld......DDIWEVIR---------------------SRKIDGEHVILDKDYFFR 67 ----------........----------------------------------------------- 68 ----------........----------------------------------------------- 69 ----------........----------------------------------------------- 70 ----------........----------------------------------------------- 71 PATAEIAAAL........----------------------------------------------- 72 ELC-------........----------------------------------------------- 73 ----------........----------------------------------------------- 74 ----------........----------------------------------------------- 75 ----------........----------------------------------------------- 76 ----------........----------------------------------------------- 77 -LSAWARRALggqv....EDAGGEYEFDLRIGQPVP----------------------------- 78 VLRAMQIEAT........PEIAVILQID---------PGDPVIFVHRLRTAGDEALVIEKRYINA 79 ----------........----------------------------------------------- 80 ----------........----------------------------------------------- 81 ----------........----------------------------------------------- 82 ELL-------........----------------------------------------------- 83 ----------........----------------------------------------------- 84 ----------........----------------------------------------------- 85 ----------........----------------------------------------------- 86 ----------........----------------------------------------------- 87 ----------........----------------------------------------------- 88 ----------........----------------------------------------------- 89 ----------........----------------------------------------------- 90 ----------........----------------------------------------------- 91 ----------........----------------------------------------------- 92 VSVLYIGPME........----------------------------------------------- 93 ----------........--------QNTNFHKLCREQGREPKTALLSGVLTTVP---------- 94 ----------........----------------------------------------------- 95 ----------........----------------------------------------------- 96 ----------........----------------------------------------------- 97 ----------........----------------------------------------------- 98 ----------........----------------------------------------------- 99 EVRTLPAGARvg......RKLRMSP-------------AAQIHYVARLRLVDGSPMAIEYLHVPA 100 EIMPAPPAIA........SQLR-------------IQINEQIYFSRRVRFVEGKPLMLEDSYMPV 101 KERQI-----........----------------------------------------------- 102 ----------........----------------------------------------------- 103 ----------........----------------------------------------------- 104 EARTE-----........----------------------------------------------- 105 ----------........----------------------------------------------- 106 PLLYQ-----........--------------------------------------------LKN 107 ----------........----------------------------------------------- 108 RVVKCPEEVA........Q-------------QLAVEAGSDVFLLKRIRYVDEEAVSI------- 109 ----------........----------------------------------------------- 110 ----------........----------------------------------------------- 111 ----------........---------------LEVPAGAGGVYVERLRRLDGLPLSLDTSYLTV 112 ----------........----------------------------------------------- 113 ----------........----------------------------------------------- 114 ----------........----------------------------------------------- 115 AARR------........----------------------------------------------- 190 200 210 220 230 | | | | | 1 PEARSLALGFY......HKLSALCSEGAHD..QVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR 2 PEARSLALGFY......HKLSALCSEGAHD..QVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR 3 PEARSLALGFY......HKLSALCSEGAHD..QVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR 4 LYSRREMLPLV......SS--------HRT..RIFEAIMAGKPEEAREASHRHLAFIEEILLD-- 5 LYARREMLPLV......ST--------HRT..RIFEAIMAGKPEEAREASHRHLAFIEEIMLD-- 6 LYSRREMLPLV......SS--------HRT..RIFEAIMAGKPEEAREASHRHLAFIEEILLD-- 7 LYSRREMLPLV......SS--------HRT..RIFEAIMAGKPEEAREASHRHLAFIEDFAR--- 8 PYWKKLHEHID......SR-TVDNWCDDHD..QILKALIRKDPHAAKLAMWQHLENTKIMLF--- 9 PYWKKLHEHID......SR-TVDNWCDDHD..QILKALIRKDPHAAKLAMWQHLENTKIMLF--- 10 PEARSLALGFY......HKLSALCSEGAH-..--------------------------------- 11 PYWRKLHEHID......DK-SIESWCEDHD..QILKALIRKDPYAAKLAMWQHLENTKQMLF--- 12 GVFYNRQIMFR......NRSTREALLEQHR..AINAAIQARDGFAARAAVAAHMDFVEVAL---- 13 MYLVPPVFSQL......TE--------QHQ..AVIDAIFAGDADGARKAMMAHLSFVH------- 14 PMWIQLHSHLD......DSLYRKEWLGDHK..QILAALIKKDARAAKLAMWQHLENVKQRLLE-- 15 ----PQYSGDP......TREDIELTHQAHA..RVAAAVLDGDGDAAAEAMREHI----------- 16 KKHRELTKQFY......LEMQQICLEGNAD..AVVDCIRKHNLRSSTYWKAILER---------- 17 LYHRPQQKKQI......DR--------QHA..RIYNAVLQRLPHVAQRAARDHVRTVKKNLHD-- 18 LYHRPQQKKQI......DR--------QHA..RIYNAVLQRLPHVAQRAARDHVRTVKKNLHD-- 19 PTVTDQALHEH......NN----VSYQQHI..AIVDAIRRHDPDEADRALQSHLNSVS------- 20 --GGREHALTG......AYDDADPVLTDLR..AINGAVLAGDPAAAAATVEAYLN---------- 21 --GGREHALTG......AYDDADPVLTDLR..AINGAVLAGDPAAAAATVEAYLN---------- 22 --AESRTESLR......QPGRPGRSLAQHR..AILDAVAARQPRQAAAAMRRHVRTV-------- 23 ---RDWLRGDV......GEGMSPAMHMDHA..RLVDAIRAGDAATAAE----------------- 24 DEA--------......---NMPQTLQEHK..ALFDAIRHQDGDAAEQAALTM------------ 25 --AQQSGLLTA......FGPRREESNEEHR..AIVDAVRKGAEAEAQAAMEFHLKKVE------- 26 AMWAQLHSRIL......QNDYHHLWIEDHQ..TILSAIQKKNANEARKAMWQHLENVKVKL---- 27 ----GVAVMHS......HPDRIAHTLAEHE..EILDALRAGDAEAAVAVVGRHVGWFSH------ 28 -----RFARWI......DWQSRRLSHEQHL..HITSLLADRKEDECAAFVLAHIQKHFDQIL--- 29 MTAAAKRPSDY......RK-----------..-LADAICSGDPTGAKKAAQDLLELAN------- 30 ----AKIDSQI......PYRERDVTVEYHK..KIYDALAQRDPYKAHYHMYEHLKFVRDKILK-- 31 LQATGQLADNL......AT---------HE..RIVDGIERGDREEAQR----------------- 32 -----RYMSFD......HVSPPEMLLRQHL..DIFSALQKRDGDAVERAMTQHLQEISESVRQI- 33 MRETRKIWLFS......KKTSVQRLYEEHE..RIYNAVAAGNGAQAEAAMLAHLTNVEDV----- 34 --FTALSIRWL......GT-VQQSYAEEHE..ELVQAFQRRDPRIAELVKAHV------------ 35 --RPDRRLQLR......VRNRLSTSFLEHC..AIVDAIFAGDGDEARRLLRGHVGIQGER----- 36 --HFCRILNYT......GDHRAETILREHR..RIFEEVKKKNKEAAKQHVLAHFN---------- 37 --EHSFLVSTR......TPGAVEASLPAHR..AVVQAVEAHDPAAAAAAVLAIVEAAEDE----- 38 --RVSDIEG--......---TVSGTLCEHD..AVLQAIRARDPEAADRAMAEHMRMAGA------ 39 VR---------......---NLEHSQRQHA..ALVEAVLDGDADGAREIAREH------------ 40 -----RFARWI......DWQSRRLSHEQHL..HITSLLADRKEDECAAFVLAHIQKHFDQIL--- 41 -----SAVAWA......ADPSWEREAGEHQ..EILRLALAGDADGAARALHAHIA---------- 42 --DRARRLGLH......ENVSPAVFVAQHR..EIFDAVTEGDVPLARTAMRTHLRAVFD------ 43 ------KHRTR......TYNARPETAAQHA..ALLDAVLGRDSAAAREAARLHVRTFGGLV---- 44 -----RVLRLS......SDLDWDIIISHHK..QIYRLIANKEAEKVRQVMEEHLRLV-------- 45 -----------......-------------..--------------------------------- 46 VIVAGNVTQRD......YQAFGRTTLAAHR..AILEAARRRDAQAVERLMAAHMDEAEAQL---- 47 --DRARRLGLH......ENVSPAVFVAQHR..EIFDAVTEGDVPLARTAMRTHLRAVFD------ 48 ---PAGSPSVR......GRADLVADAHQHT..ALLDALIAGDLDVVRALVGDHF----------- 49 ----RWYYTPV......ARQRGRQSWIEHR..RLIAAVTERDEQAATRLMREHTEH--------- 50 -----------......-------------..--------------------------------- 51 AVVPDYLHQDYtattphDYLSLIAPLTEGE..HIVEAVQATAEECALLHIHAH------------ 52 --FTALSIRWL......GT-VQQSYAEEHE..ELVAAFRRRDPRIPEIV---------------- 53 ------DLVRH......LNERYVVSNREHK..ELIERIISGDKEGAIEKLKEHLKNVEAE----- 54 --RLAFHVVDD......PRRLHEPYIARNA..EILSTLESGEREAAARLLAVYLEN--------- 55 AIAPDYLKQDF......TRQTPYAYLSQVA..PLT------------------------------ 56 -----IWLPIG......PPIDVAAYVEEKH..AISAAIAAENAQEARQLAEAH------------ 57 ERIREGTWRYL......ETKTGRVVVQGQD..RV------------------------------- 58 STAPDYMKQDF......NQITPYSYLTQAA..PLT------------------------------ 59 -----------......-------------..--------------------------------- 60 ERIKEGSWAYL......EEQTGMTAVYGQD..RI------------------------------- 61 -----------......-------------..--------------------------------- 62 -----------......-------------..--------------------------------- 63 LTLWPTLQRFD......SGSLHDFLRE---..--------------------------------- 64 ALIGPLTAQDV......TDASLYGLLGQ--..--------------------------------- 65 -----------......-------------..--------------------------------- 66 KHVPHLTKEIC......ENSIYEYI-----..--------------------------------- 67 -----------......-------------..--------------------------------- 68 -----------......-------------..--------------------------------- 69 -----------......-------------..--------------------------------- 70 -----------......-------------..--------------------------------- 71 -----------......-------------..--------------------------------- 72 -----------......-------------..--------------------------------- 73 -----------......-------------..--------------------------------- 74 -----------......-------------..--------------------------------- 75 -----------......-------------..--------------------------------- 76 -----------......-------------..--------------------------------- 77 -----------......-------------..--------------------------------- 78 RMVPNLLE---......-------------..--------------------------------- 79 -----------......-------------..--------------------------------- 80 -----------......-------------..--------------------------------- 81 -----------......-------------..--------------------------------- 82 -----------......-------------..--------------------------------- 83 -----------......-------------..--------------------------------- 84 -----------......-------------..--------------------------------- 85 -----------......-------------..--------------------------------- 86 -----------......-------------..--------------------------------- 87 -----------......-------------..--------------------------------- 88 -----------......-------------..--------------------------------- 89 -----------......-------------..--------------------------------- 90 -----------......-------------..--------------------------------- 91 -----------......-------------..--------------------------------- 92 -----------......-------------..--------------------------------- 93 -----------......-------------..--------------------------------- 94 -----------......-------------..--------------------------------- 95 -----------......-------------..--------------------------------- 96 -----------......-------------..--------------------------------- 97 -----------......-------------..--------------------------------- 98 -----------......-------------..--------------------------------- 99 DLVSDLTSEEL......EQGDLYEHLGERHdvRVSEAVQSIEPTVVTRAEADLL----------- 100 KLFRNLSLQHL......EG-----------..--------------------------------- 101 -----------......-------------..--------------------------------- 102 -----------......-------------..--------------------------------- 103 -----------......-------------..--------------------------------- 104 -----------......-------------..--------------------------------- 105 -----------......-------------..--------------------------------- 106 MVHEEDYEKWF......SYGRAGESLWQ--..--------------------------------- 107 -----------......-------------..--------------------------------- 108 -----------......-------------..--------------------------------- 109 -----------......-------------..--------------------------------- 110 -----------......-------------..--------------------------------- 111 DVGRAVLAGDL......-------------..--------------------------------- 112 -----------......-------------..--------------------------------- 113 -----------......-------------..--------------------------------- 114 -----------......-------------..--------------------------------- 115 -----------......-------------..---------------------------------