; SAM: prettyalign v3.1b (February 24, 1999) compiled 04/18/00_11:44:15 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ------ Citations (HMMs, SAM) ------ ; A. Krogh et al., Hidden Markov models in computational biology: ; ------------- Citations (SAM, SAM-T99, HMMs) ----------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; -------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 T0093 ; 2 gi|1176303|sp|P44868|YIBK_HAEIN_1:159 ; 3 gi|1381681|gb|AAB02738.1|_2:155 ; 4 gi|7475809|pir||G69608_5:158 ; 5 gi|7225492|gb|AAF40722.1|_1:150 ; 6 gi|7380837|emb|CAB85429.1|_1:150 ; 7 gi|2222703|emb|CAB09926.1|_16:167 ; 8 gi|418440|sp|P32813|YGL3_BACST_2:155 ; 9 gi|549584|sp|P33899|YIBK_ECOLI_1:153 ; 10 gi|7468542|pir||E72052_2:145 ; 11 gi|666878|gb|AAB41347.1|_3:147 ; 12 gi|7469033|pir||C71503_2:145 ; 13 gi|7478931|pir||E70971_1:151 ; 14 gi|2500863|sp|P75257|Y346_MYCPN_5:160 ; 15 gi|3915412|sp|P74516|Y992_SYNY3_1:149 ; 16 gi|3915411|sp|P74328|Y955_SYNY3_217:366 ; 17 gi|1723153|sp|P47588|Y346_MYCGE_6:160 ; 18 gi|732016|sp|P39290|YJFH_ECOLI_95:242 ; 19 gi|586908|sp|Q06753|YACO_BACSU_97:245 ; 20 gi|3915481|sp|P74261|YG73_SYNY3_120:267 ; 21 gi|6968342|emb|CAB73162.1|_1:148 ; 22 gi|1176354|sp|P44906|YJFH_HAEIN_95:243 ; 23 gi|6687040|emb|CAB64790.1|_96:243 ; 24 gi|4104449|gb|AAD02043.1|_2:149 ; 25 gi|7474350|pir||S71440_2:143 ; 26 gi|7473863|pir||A75448_116:261 ; 27 gi|134838|sp|P19396|TRMH_ECOLI_19:174 ; 28 gi|7380020|emb|CAB84598.1|_114:258 ; 29 gi|7226378|gb|AAF41528.1|_56:200 ; 30 gi|2500862|sp|P75424|Y252_MYCPN_96:238 ; 31 gi|7477670|pir||A70607_160:308 ; 32 gi|3915369|sp|O51468|Y516_BORBU_78:225 ; 33 gi|6899239|gb|AAF30677.1|AE002123_10_1:168 ; 34 gi|6899082|gb|AAF30530.1|AE002113_4_90:230 ; 35 gi|7473864|pir||C75301_22:183 ; 36 gi|7448026|pir||A70463_93:236 ; 37 gi|7468541|pir||C72066_116:262 ; 38 gi|7477844|pir||G70619_108:256 ; 39 gi|7481299|pir||T36832_120:271 ; 40 gi|7473665|pir||G75542_10:154 ; 41 gi|7469036|pir||F71519_117:266 ; 42 gi|7448027|pir||D72218_90:239 ; 43 gi|3915169|sp|O67577|TRMH_AQUAE_25:182 ; 44 gi|2127985|pir||C64484_4:158 ; 45 gi|3253066|dbj|BAA29043.1|_1:156 ; 46 gi|1723134|sp|P47494|Y252_MYCGE_96:238 ; 47 gi|7475810|pir||G69984_105:244 ; 48 gi|5032157|ref|NP_005637.1|_1463:1612 ; 49 gi|1731374|sp|Q10543|Y881_MYCTU_131:279 ; 50 gi|7429550|pir||C69114_10:169 ; 51 gi|6899305|gb|AAF30736.1|AE002130_3_114:254 ; 52 gi|465634|sp|P33635|YFIF_ECOLI_198:342 ; 53 gi|7226592|gb|AAF41722.1|_14:191 ; 54 gi|6015729|emb|CAB57556.1|_1:156 ; 55 gi|7380201|emb|CAB84787.1|_35:212 ; 56 gi|6320091|ref|NP_010171.1|_1285:1429 ; 57 gi|1199536|emb|CAA64900.1|_331:475 ; 58 gi|7242757|emb|CAB77330.1|_165:312 ; 59 gi|7485251|pir||T01767_81:251 ; 60 gi|7429552|pir||S76714_2:147 ; 61 gi|1709266|sp|P52391|NHS_STRAS_118:259 ; 62 gi|7473664|pir||E75501_12:164 ; 63 gi|136456|sp|P18644|TSNR_STRAZ_117:260 ; 64 gi|695296|gb|AAB41449.1|_2:113 ; 65 gi|7448028|pir||A64589_86:222 ; 66 gi|7445204|pir||C72640_3:150 ; 67 gi|7022703|dbj|BAA91694.1|_209:406 ; 68 gi|7293773|gb|AAF49141.1|_235:398 ; 69 gi|7464733|pir||G71924_86:222 ; 70 gi|1903046|emb|CAB07516.1|_3:112 ; 71 gi|3915341|sp|O51081|Y052_BORBU_34:176 ; 72 gi|3046324|gb|AAC24483.1|_4:157 ; 73 gi|7481298|pir||T36705_118:249 ; 74 gi|547828|sp|P37006|LAST_SERMA_10:122 10 20 30 40 | | | | 1 MLDIVLYEPEIPQNTGNIIRLCANTGFRLHLI........EPLG....FTWDD.KR....LRRSG 2 MLDIVLYEPEIPQNTGNIIRLCANTGFRLHLI........EPLG....FTWDD.KR....LRRSG 3 ALHVVLYQPEIPANTGNIARTCAATNTTLHLI........RPLG....FSTDD.KM....LKRAG 4 ALHVVLYHPEIPANTGNIARTCAATNTTLHLI........RPLG....FSTDD.KM....LKRAG 5 MFTIVLYQPEIPPNTGNIIRLCANTGADLHLV........KPLG....FPLDS.AK....MKRAG 6 MFTIVLYQPEIPPNTGNIIRLCANTGADLHLV........KPLG....FPLDS.AK....MKRAG 7 MFRLLFYTPRIPPNTGNAIRTAAVTGCALHLV........EPIG....FDLSN.PK....LRRAG 8 ALHVVLFQPEIPANTGNIARTCAATNTALHLI........RPLG....FSTDD.KM....LRRAG 9 MLNIVLYEPEIPPNTGNIIRLCANTGFRLHII........EPMG....FAWDD.KR....LRRAG 10 --RVVLHCPDIPQNTGNIGRTCVALGAELILV........RPLG....FSLAD.KF....VKRAG 11 ---VVLYNPDIPQNTGNIGRTCIALGAELILV........RPLG....FSLLD.KF....VKRAG 12 --RIVLHNPDIPQNTGNIGRTCVALGAELILV........RPLG....FSLAD.KF....VKRAG 13 MFRLLFVSPRIAPNTGNAIRTCAATGCELHLV........EPLG....FDLSE.PK....LRRAG 14 AINIVLFCPEIPNNTGNIVRSCTAFKANLHLI........KPYG....FFLND.KR....MVRAG 15 MVKLVLVNPQIPPNTGNIARTCAATGTELHLV........GPLG....FELGD.RY....LKRAG 16 PVLIIIDSITDPHNLGAIIRTAEAFGAQGMVL........PQRR....VAGIT.ST....VMKVA 17 -INIVLFCPEIPNNTGNIVRSCTAFKANLHLI........KPYG....FFLND.KR....MVRAG 18 PFLLILDGVTDPHNLGACLRSADAAGVHAVIV........PKDR....SAQLN.AT....AKKVA 19 PFFLILDELEDPHNLGSIMRTADAVGAHGIVI........PKRR....AVGLT.TT....VAKAS 20 RLGLVLERLQDPGNLGTILRTAAATGVEGIWL........TADC....VDPTS.PK....VLRSS 21 MFNIVLVHPRIPQNTGSIGRMCFNAGFKLHIV........KPIV....FDISQ.KA....VRRAG 22 PLLLVLDGVTDPHNLGACLRTADAAGAVAVIV........PKDK....SAQLT.SI....ARKVA 23 PLLLALDGVTDPHNLGACLRVADGAGAHAVIA........PRRR....AAGLT.AA....AAKAA 24 ELRVALYQPDIPGNTGTILRMAACLGFAVDLI........EPAG....FDISD.RA....LKRAG 25 ALHIVLVEPEIPANTGNIARTCAATGTHLHLV........RPLG....FNTDD.KT....LKRAG 26 -VVVVLHGLEKPGNVGAILRTADAAGAAGVLV........LGRG....ADPYG.PN....VIRAS 27 DLTVCMEQVHKPHNVSAIIRTADAVGVHEVHA........VWPG....SRM--.RT....MASAA 28 --CVVLDGVQDPGNVGTVLRSAAAAGIGAVIL........GKGC....ADAWS.PK....VLRAG 29 --CVVLDGVQDPGNVGTVLRSAAAAGIGAVIL........GKGC....ADAWS.PK....VLRAG 30 -TLVMLHEIQDPHNFGAILRTCMAAEVDGIIF........KKHN....QAPIN.ST....VIRTS 31 ALLVALDNLSDPRNLGAIVRSVAAFGGHGVLI........PQRR....SASVT.AV....AWRTS 32 AFILLLDEIEDPQNFGAILRTAEQFSIDLVIT........TQKR....SAKDN.ST....VLRTS 33 MLNIVLFEPEIILNTGNIARMCVGFDANLHLV........RPYG....FILDK.KRfhkdFIRAS 34 ALVLILDEIEDPRNFGAIIRTANGFGVDAIIY........KKHH....QASIN.DL....VIKTS 35 -LTVLMDEVNKPHNLSAIIRTCDAVGVPEAHA........VPPKhgtlASFEG.HT....YEATS 36 SFFIVIDHITDPQNVGNLLRTCEVLGGVGALI........SKDR....TSPIN.ET....VVKAS 37 PFYLIIEQVEKPGNVGAILRIADGAGVDGVIL........CNPI....VDLYN.PN....VVRSS 38 QLIAVTVEIREPGNAGTVIRIADAMGAAAVIL........AGRS....VDPYN.GK....CLRAS 39 -LVAVLAHVRDPGNAGTVLRCADAAGAEAVVL........TDAS....VDLYN.PK....AVRAS 40 LLHVVLFEPEKAGNVGNVARTCSVLGAELHLI........RPFG....FHLHD.RE....FRRAV 41 PFYLIVEQAEKPGNIGALLRIADGAGVDGVIL........CDPV....VDLYN.PN....VIRSS 42 PLIVLLDQIQDPHNLGAIVRTSVGAGANGIII........PKDK....SVKVT.ET....VVKVS 43 DLIVFADNVKNEHNFSAIVRTCDAVGVLYLYY........YHAE....-GKKA.KI....NEGIT 44 MISVILVNPKYSGNVGSIARVMMNFGFEELRI........VGDK....SIINN.EA....YMMAV 45 MISVVLVEPEGPANIGMIARTMKNFGFSRLVL........INPN....--LTE.ES....YAYAV 46 -TLVMLDEIQDPYNFGAILRTCLASEVDGIIF........KKNN....QVPIN.NT....VMKTS 47 -KVLLIDAVQDPGNLGTMIRTADAAGLDAVVL........GDGT....ADAFN.GK....TLRSA 48 RLIVVASLIDKPTNLGGLCRTCEVFGASVLVV........GSLQ....CISDK.QFq...HLSVS 49 -TVAVLEGVNDHENLGSIFRNAAGLSVDAVVF........GTGC....ADPLY.RR....AVRVS 50 NISVVFVEPETPGNIGFLARAMKNFGLRTLIL........INPC....-ELED.EA....YYQAM 51 -NILLLDNIQDPGNLGTILRTCFAFNIKQVIF........-NNC....VDLYN.PK....TIKAS 52 -CVLALENESNPHNLGGMMRSCAHFGVKGVVV........QDAA....-LLES.GA....AIRTA 53 NIRIILTRTSHPANIGSAARAMKTMGLHKLTIvap20dpeHPQS....FKLPE.ES....FILAS 54 MIRVVLVEPEGEYNIGFVARLCKNFLVDELYI........VNPR....-ANIS.EA....FRFSA 55 NIRIILTRTSHPANIGSAARAMKTMGLHKLTIvap20dpeHPQS....FKLPE.ES....FILAS 56 ELIVVSSLVDKPPNLGGICRLCDVLGVGLLTV........QDIK....VKNHP.QF....KNVAV 57 ELIVVSSLVDKPPNLGGICRLCDVLGVGLLTV........QDIK....VKNHP.QF....KNVAV 58 PLIVALDGVTDPRNLGAVVRSVSAFGGHGVVV........PERR....AAGMT.AG....AWKTS 59 LLHVVLVSPQIPGNTGCIARTCAASAVGLHLVgvn14fllQPLG....FQVDD.AR....VKRAG 60 -------EPQGERNVGAIARAMKNMGLEELIL........VNPR....CDYRSvEA....QTMAV 61 --VVVLDGVKIVGNIGAIVRTSLALGAAGIVL........VDSDl...ATIAD.RR....LLRAS 62 SLAVVLVSPKTPGNIGAAARAMLNMGASDLRI........VAPR....CDYLDsQA....VAMAV 63 -DVVVLDGVKIVGNIGAIVRTSLALGASGIIL........VDSDi...TSIAD.RR....LQRAS 64 --------------------------------........--LG....FSLAD.KF....VKRAG 65 -KLLVLCGITDVGNIGGIFRSAYCLGMGGVIL........DFAK....-ELAY.EG....IVRSS 66 --------TEGAVNLGFVARLAENFEADEIYL........VSPR....-ASLE.EA....KRYAA 67 PLLLICDNLRDPGNLGTILRSAAGAGCSKVLL........TKGC....VDAWE.PK....VLRAG 68 PITVVCDNIREPNNLGSIIRTCAALPCSQVVV........THGC....CDPWE.SK....ALRGG 69 -KLLVLCGITDVRNIGGIFRSAYCLGMDGVIL........DFAR....EFAY-.EG....IVRSS 70 --------------------------------........----....-----.--....-KRAG 71 YLTFVLEDIFQSQNASATIRTGEILGLSDVHVi.......EKKN....KHTLN.PD....V---T 72 SIRVVLVNTSHPGNIGGAARAMRNMGLSRLYL........VAPE....DFPSS.EA....VARAS 73 -PVVVLDQPRNLGNAGAVIRLAAGFGATGVVT........TGTL....-DPWH.PT....VVRGG 74 --------------------------------........----....-----.AA....RWVAH 50 60 70 80 90 | | | | | 1 L.DYHEFAEIKRHKTFEAFLES..EKPKRLFALTT........KGCPAHSQV.KF........KL 2 L.DYHEFAEIKRHKTFEAFLES..EKPKRLFALTT........KGCPAHSQV.KF........KL 3 L.DYWEFVNVVYHDSLEELFEA..YKKGKFFFITK........FGQQPHTSF.DYtdl.....DE 4 L.DYWEFVNVVYHDSLEELFEA..YKKGKFFFITK........FGQQPHTSF.DYtdl.....DE 5 L.DYHEFASLTVHENFDDCLKA..LAGRRIFALTT........KGTARPDET.AF........QK 6 L.DYHEFASLTVYENFDDCLKA..LAGRRIFALTT........KGTARPDET.AF........QK 7 L.DYHDLASVTVHTSLSEAWNA..LSPARVFAFST........LANTLFTDV.SY........QA 8 L.DYWEFVNIHYYDSLDHFFQQ..NQNGDFYYITK........FGKRYYTSY.DFsdp.....SK 9 L.DYHEFTAVTRHHDYRAFLEA..ENPQRLFALTT........KGTPAHSAV.SY........QD 10 M.DYWDKLQLTVVDSIEEALHD..VPEDQIFCLST........KGSASYTEF.SL........PS 11 M.DYWDKVNLSVVDSLDEALSG..VDQNKVFCLST........KGSQYYGDV.SL........PM 12 M.DYWERLSLSVVDSLEEALLG..VPKERIFCLTT........KGSSYYGER.EL........PL 13 L.DYHDLASVTVHASLAHAWEA..LSPARVFAFTA........QATTLFTNV.GY........RA 14 L.NCWDKVQMFEHKSWEHFIET..TPPNKAIWLLTksgtt...TPDQINMQT.DN........RE 15 L.DYWPYVDLHYHNSCEEFITH..WRGQGGNLLGFsv......TGTVNFWDY.TY........QS 16 A.GALEHFPVARVVNLSRALET..LKESGFWIYGTva......GKQTALHQA.DL........RE 17 L.NCWDKIQLFEHKSWEHFLQA..TTENKTIWLLTksgdk...TPDQICMTN.KL........PN 18 C.GAAESVPLIRVTNLARTMRM..LQEENIWIVGTag......EADHTLYQS.KM........TG 19 T.GAIEHIPVARVTNLARTLEE..MKERGIWVVGTda......SAREDFRNM.DG........NM 20 A.GSSLLLPQQQLQSLPPLLEK..FHTQGLQLIATvp......QATQTLWEI.DF........QR 21 L.DYWDKLEPIIWENLEEFLNEnmIYKNRFFFATT........KSQKAYFDA.EF........QK 22 C.GAAETVPLIRVTNLSRTLRD..LQQNHNIWVVGtag.....EATETIYQS.KL........TG 23 N.GAAETVPYLTVINLARALRA..LKNAGIQVIGTad......DATTSLFDI.QL........DG 24 M.DYLEQAALTRHPDWNRFDAW..RKNAGRGLVLLst......KAAIPYTGY.QF........QE 25 L.DYWYAVHIEYHDSFEELQQK..YPEGRFFYTST........KATKRYCDI.AF........QD 26 Q.GAVFSVPTAVLGEDAALGWL..AEHNFRTVACTp.......DAPADYWDT.PL........TG 27 A.GSNSWVQVKTHRTIGDAVAH..LKGQGMQILAThls.....DNAVDFREI.DY........TR 28 M.GAHFLSEIYPQADLEIWLVR..YKGRVFATALRe.......EKQAVLYGE.DL........CE 29 M.GAHFLSEIYPQADLEIWLVR..YKGRVFATALRe.......EKQAVLYGE.DL........CE 30 M.GTVFYQNLVQVTNLSYAITT..LQKHGFWTVATtlder...LKPKDYRQV.DF........-D 31 A.GAAARIPVARATNLTRTLKG..WADRGVRVIGLda......GGGTALDDV.DG........TD 32 S.GASQYVKKMTVTNINNTINL..LKNYGFWIYTGd.......IKGQDINKI.KIn.......DK 33 T.NHLNALKLYEYDDFNEFINK..NNISGDEIYFFtr......YGTKTPCDY.QYqnii....QH 34 M.GAINYIYMIEVNNLSNTIKN..LQDEGFWVYATsl......LKSQPYEKV.DY........AN 35 G.SAHKWVKVHPHADAVSAVRE..LQAQGFQVLAThls.....QRSVDYREP.DY........TK 36 S.GAVFHLKISKVSSLSRELKN..FQKMGGWVFAVe.......KGGKDIREV.DI........PL 37 L.GAVFSLPILSI-SREEGKEL..FKQEGWTVFVTsp......RAETMYFSK.NY........LG 38 T.GSIFAIPVVVAPDVGAAIAD..LRAAGLQVLATav......DGEMALDDA.DRll......AE 39 V.GSLFHLPVAVGVPVERAVAG..LREAGVRVLAAd.......GAGEDDLDT.ELdagtm...GG 40 M.DYLQGVTLHEYAGWSDFQAQ..LPDAARVFAFSt.......HATEYHTRA.GF........KR 41 L.GTVFTMPVWQ-ASLKEVLDL..VHQQEWQVFTTtp......SAQTFYFDQ.DF........CQ 42 A.GTVFRARIAVVTNLARTIEE..LKEKGVWTYASd.......IDGTPIYEE.DF........TF 43 Q.GSHKWVFIEKVDNPVQKLLE..FKNRGFQIVATwls.....KESVNFREV.DY........TK 44 H.AREILDNAKFYNTFDEAIGD..LDFVIATSGAR........GGDRNLKRV.PItpk12levKG 45 H.ARDVLENALILDSFEKALEL..FDFTVGTTGKP........GKRFIPHRA.PLmpw12kdyPG 46 M.GSVFYQNLVQVANLSYTITK..LKEIGFWTVVStldpi...WKPIDYRKV.DF........AK 47 Q.GSHFHIPVVR-RNLPSYVDE..LKAEGVKVYGTal......QNGAPYQEI.PQ........SE 48 A.EQWLPLVEVKPPQLIDYLQQ..KKTEGYTIIGVeqt.....AKSLDLTQY.CF........PE 49 M.GHALLVPYARAADWPTELMT..LKESGFRLLAM........TPHGNACKL.PEaiaavs..HE 50 H.ARDIVEGALIYRDLSEMIDS..LEPDFLVGTTGvp......GGSYNVDRI.PLrps11irpSS 51 M.GAIFKINFLRFNDSKLALNF..LLKNKFYLIATild.....KNAISLNEI.TI........KQ 52 E.GGAEHVQPITGDNIVNVLDD..FRQAGYTVVTTss......EQGKPLFKT.SL........PA 53 G.AADVLENATIAASLDEALAD..TTIACALTSRR........REITAPLQT.PRdlv12anrGE 54 G.GREILEKAKIVNTFDKAIND..VDIKIATSSIA........DNNGDILRK.SIrpw10liqGK 55 G.AADVLENATIAASLDEALAD..TTIACALTSRR........REITAPLQT.PRdlv12anrGE 56 TaDRWMPMEEVALDEIASFMKE..KKKEGYTLIGLeqtd....KSVKLDNNF.QF........PK 57 TaDRWMPMEEVALDEIASFMKE..KKKEGYTLIGLeqtd....KSVKLDNNF.QF........PK 58 A.GTAARTPVARATNLTRALEQ..YQKAGITVVGLaa......DGEAELGDLaAL........DG 59 G.R----------KTNDSFYKK..RNKDTFKIATItsnwvaenNGYNLMQDF.SY........RS 60 H.AKDVLAQAKVVDDLATALGD..RQRIIATSAREril9pmetPRQALPWLL.AP........NL 61 R.GYVFSLPVVLADREEAVSFL..RDNDIALMVLDt.......DGDLGVKDLgDR........AD 62 H.AGDLLRSAKIYPTLREALAD..RDLSVGTSARI........RADLPAPRH.PAqvrglvreAA 63 R.GYVFSLPVVL-SGREEAIAF..IRDSGMQLMTLka......DGDISVKELgDN........PD 64 M.DYWERLSLSVVDSLEEALLG..VPKERIFCLTT........KGSSYYGER.EL........PL 65 L.GLMYDLPFSVMPNTLDLINE..LKTSGFLCLGAsm......QGSSQIENL.SL........-K 66 R.AAWRLDAARVVSNLEEALRG..VSASLCTSSHMsdrdal..RAPLAPWEA.AEvlaat...PG 67 M.GAHFRMPIINNLEWETVPNY..LPPDTRVYVADn.......--CGLYAQA.EMsnk49dwtEA 68 C.GGQFRVPIRDDVTWDELALT..IPPEAADDCHVfia12renNQTIDYADI.--kgl.....GA 69 L.GLMYDLPFSVMPNTLDLINE..LKTSGFLCLGAsm......QGSSQAENL.SL........-K 70 L.DYWEFVNVVYHDSLEELFEA..YKKGKFFFITK........FGQQPHTSF.DYtdl.....DE 71 L.GSSQWINLNKYKNAKFAIDR..LKSDGYSIVATsln.....PKSINLENL.TI........NN 72 G.ATDILDNAQVVATLEEALVG..CTLALGTSARDrri12preCAATCLEQV.GQ........GA 73 A.GLHF-------ATVVERLEV..AGLPPGPLFALd.......PEGEDIRGL.EL........PD 74 G.AGEILDGVQTFATLEQALAD..VDFTVATTARS........RARFHYYCT.PPell12kqwVG 100 110 120 130 140 150 | | | | | | 1 GDYLMFGPETRGIPMSILNEMPM....EQKIRIPM.TA.NSRSMNLSNSVAVTVYEAWRQLGYKG 2 GDYLMFGPETRGIPMSILNEMPM....EQKIRIPM.TA.NSRSMNLSNSVAVTVYEAWRQLGYKG 3 DYFFVFGRETSGLPKDLIQNN-M....DRCLRLPM.TE.HVRSLNLSNTAAILVYEALRQQNYRD 4 DYFFVFGRETSGLPKDLIQNN-M....DRCLRLPM.TE.HVRSLNLSNTAAILVYEALRQQNYRD 5 GDVLLFGPETRGLPADILDSLPA....AQKIRLPM.QP.GSRSMNLSNTVAVILFEAWRQHGY-- 6 GDVLLFGPETRGLPADILDSLPA....AQKIRLPM.QP.GSRSMNLSNTVAVILFEAWRQHGY-- 7 GDVLMFGPEPTGLDAATLADDHI....TQQVRIPM.LS.GRRSLNLSNAAAVAVYEAWRQHGYAG 8 EIFFIFGRETTGLPKELLAENE-....DRCLRIPM.TE.NVRALNLSNTAAILVYEALRQQSFHG 9 GDYLMFGPETRGLPASILDALPA....EQKIRIPM.VP.DSRSMNLSNAVSVVVYEAWRQLGYPG 10 SGTYVFGSESKGLPKEILKKY-Y....KNCLRIPM.QQ.DIRSLNLATSVGIVLYEVVRQ----- 11 DGVYVFGSESKGLPEDVLKKY-Y....NHCYYLPM.RP.GIRSLNLATTVGVVLFEAVRQNN--- 12 DGTYIFGAESKGLPQTVLDAYS-....SQCLYIPM.IE.GTRSLNLATSVGIVMYEVARQ----- 13 GDVLMFGPEPTGLDEATLADTHI....TGQVRIPM.LA.GRRSLNLSNAAAVAVYEAWRQHGFA- 14 QLYFVFGQETKGLPQTLMEQYS-....QNQVRIPI.WN.PVRSINLSNTVACVLYEYAKQNHYFN 15 TDWLMMGSETDGLPQMMRDLS--....TQLLCIPMpHS.EVRSLNLASSAAIALFEAGRQL---- 16 PMGLVIGSEGEGLSLLTQKHC--....DHLITIPL.AG.KTPSLNASVAAAISLYEIFRQRGF-- 17 ELYFVFGQETKGLPKTIMDNFK-....QNQIRIPI.WN.SVRSINLANAVVCILYEYSKQNQYSN 18 RLALVMGAEGEGMRRLTREHC--....DELISIPM.AG.SVSSLNVSVATGICLFEAVRQR---- 19 PLALVIGSEGKGMGRLVKEKC--....DFLIKLPM.AG.KVTSLNASVAAGLLMYEVYRKRN--- 20 PTIVIFGSEGQGLSAPVLELT--....THQVAIPQ.AP.QVESLNVAIAVGVMLYEARRQQ---- 21 NDFLFFGSESYGLPMELMQLN-W....ENAITIPM.KS.YGRSLNLATSVGIISYEALRQ----- 22 PLALVMGAEGEGMRRLTREHC--....DQLISIPM.AG.SVSSLNVSVATGVCLFEIVRQR---- 23 ALALVMGAEGAGMRRLTREAC--....DEVVRIPL.AG.HVQSLNVSVASGICLFEAVRQR---- 24 NDILLFGRESAGVPEAIHDNA--....DERLLIPM.VR.SARSLNLAVSVAMTTGEALRQI---- 25 GDFLVFGKETKGLPPELLAANP-....DSCIRMPM.TD.KVRSLNLSNSAAIIVYE--------- 26 RVALLLGTEHAGLPAEWRAAH--....-QAVRVPM.HG.QADSLNVATAAALVLYEALRQRR--- 27 PTCILMGQEKTGITQEALALA--....DQDIIIPM.IG.MVQSLNVSVASALILYEAQRQRQNAG 28 PTAWVFGNEGAGVGKAVLDRA--....DKCVRIPM.HD.ATESLNVAMAATICLFEQMRQR---- 29 PTAWVFGNEGAGVGKAVLDRA--....DKCVRIPM.HD.ATESLNVAMAATICLFEQMRQR---- 30 KRILLVGNEDKGLNALLLKNA--....DLKVKIPM.NP.KLNSLNVSVAVGIILF---------- 31 SLVVVVGSEGKGLSRLVRQNC--....DEVVSIPM.AA.QAESLNASVAAGVVLAEIARQRR--- 32 KIALILGNEGKGVHKLIKENS--....DFLIRIPT.SG.KIDSLNVSVSTGILIFEIKRQL---- 33 NVYLVFGKESTGIDHNILKKYP-....HNWIRIPT.SI.NLRSLNIANSVAMGIYEVVRQNNFKD 34 KTVFIVGNENKGVSPLILKNA--....DQSIRIDM.FG.DVQSLNVGVATGIIL----------- 35 PTCVLLGAEKWGVSDEAAEAA--....DANIVIPM.FG.MVQSLNVSVAAATILFEAQRQRLAAG 36 PVALVLGSEDKGVSKSVLDIS--....DQIVTIPM.KG.KVTSLNVGSAGAIAMWETA------- 37 PTALVFGSEKDGLTEDWFSED--....FSEIALPM.LG.ESDSLNLATSVAAVAYEVVRQR---- 38 PTAWLFGPEAHGLSAEIAALA--....DHRVHILM.SG.GAESLNVAAAAAICLYESARA----- 39 PTAWVFGNEAWGLPEETRALT--....DAVLRVPI.HG.KAESLNLATAAAVCLYASARAQR--- 40 GDYLLFGPESRGLPVWLRDAL--....-PKLKLPQ.PG.RGRSLNLSVAVGAAAFEAGRQ----- 41 PMVVVFGSEKDGLSPDWLNGS--....FCNIALPM.LG.KADSLNLSSSVAAVAYEVVRQRSIR- 42 PTAFVFGNEGEGIRRLVREKC--....DRVVTIPM.EN.DIDSLNVSVSVGVVLFEAVRQRRMK- 43 PTVLVVGNELQGVSPEIVEIA--....DKKIVIPM.YG.MAQSLNVSVATGIILYEAQRQREEKG 44 NIGIVFGREDDGLRNEEIDKC--....DLLVSIPT.SE.KYPIMNLSHAVAVILYEIY------- 45 EVGIFFGRESIGLKNEELDAM--....DVTLTIPT.SE.EYPVMNLAQAAAVVLYELSKKR---- 46 K-ILIVGNEDRGVNQLITKNA--....DCRIKIPM.NN.KINSLNVSVALGIILF---------- 47 SFALIVGNEGAGVDAALLEKT--....DLNLYVPL.YG.QAESLNVAVAAAILVY---------- 48 KSLLLLGNEREGIPANLIQQL--....DVCVEIPQ.QG.IIRSLNVHVSGALLIWEYTRQQ---- 49 RIALLVGAEGPGLTAAALRIS--....DVRVRIPM.SR.GTDSLNVATAAALAFYERTR------ 50 GTFILFGREGDGLSNEEIGLC--....DMVVSVPT.SE.EYPIMNITHAAAIIFYELFRDREF-- 51 KYCLMVGNEGHGLVQTFIDHA--....HIKTMIKM.-N.QTESLNVAVAAAIFLYE--------- 52 KMVLVLGQEYEGLPDAARDPN--....DLRVKIDG.TG.NVAGLNISVATGVLLGEWWRQ----- 53 KVALVFGNETFGLSIEEVQAC--....NRLMTING.NP.DYFSLNLAQAVQVVCYEIFSQT---- 54 KIALIFGRESVGLTREEIFKC--....DFLLYIPA.NP.SYPVLNLSHAVGIVLYEIWKNRE--- 55 KVALVFGNETFGLSIEEVQAC--....NRLMTING.NP.DYFSLNLAQAVQVVCYEIFSQT---- 56 KSLILLGTEAFGIPGTLLSEL--....DLCLEIQQ.FG.VIRSMNIQTATAVIVH---------- 57 KSLILLGTEAFGIPGTLLSEL--....DLCLEIQQ.FG.VIRSMNIQTATAVIVH---------- 58 PVVIVVGSEGKGLSRLVGETC--....DFRVRIPM.PG.GAESLNAGVAAGIVLYEAARR----- 59 GDYLLFGSETSGLPPEALSDCNHepygGGTLRIPM.VEtYVRCLNLSVSVGIALYEASRQLNYEQ 60 KSALVFGREDSGLTNEELNQA--....HRFVRIPV.HP.QYPSLNLSQAVMVCTYELY------- 61 RMALVFGSEKGGPSGLFQEAS--....AGTVSIPM.LS.STESLNVSVSVGIALHE--------- 62 APALVFGPEETGLINSDLEQC--....QVTVRIPT.-G.DYASLNLAQAVLLVCYEFLQG----- 63 RLALLFGSEKGGPSDLFEEAS--....SASVSIPM.MS.QTESLNVSVSLGIALHER-------- 64 DGTYIFGAESKGLSQTVLDAYS-....SQCLYIPM.IE.GTRSLNLATSVGIVMYEVARQ----- 65 KCALFLGSEHEGLSKKILAKM--....DTILSVKM.RR.DFDSLNVSVAAGIL------------ 66 TVAIVFGRESVGLTRGEIALC--....SLYSSIPA.SP.RYPSLNLSNAAAIYLYEVYKAR---- 67 PAAVVIGGETYGVSLESLQLAEStg..GKRLLIPV.VP.GVDSLNSAMAASILLFEGKRQL---- 68 HNLLIIGGESHGVSEEAYRFLNLvggkGKCIYIPL.AA.GIDSLNVASALTLLLFELRRK----- 69 KCALFLGSEHEGLSKKILAKM--....DAILSVKM.RR.DFDSLNVSVAAGIL------------ 70 DYFFVFGRETSGLPKDLIQNN-M....DRCLRLPM.TE.HVRSLNLSNTAAILVYEALRQQNYRD 71 KMAIFFGTELTGLSAEVLGAA--....DLYVKIPM.YG.FTQSYNISVAVAIVMYSL-------- 72 EVALVFGREYAGLTNEELQRC--....QFHVHIPS.DP.SFSSLNLAAAVQVLVYEV-------- 73 DALLAFGSERSGLTPELRARA--....DRLVALPM.RP.QVSSYNLATSVAMTLY---------- 74 QAALVFGREDSGLTNEELALA--....DLLTGVPM.QA.DYPSLNLGQAVMVYCYQL-------- 160 | 1 AVNLPEVK 2 AVNLPEV- 3 -------- 4 -------- 5 -------- 6 -------- 7 -------- 8 -------- 9 A------- 10 -------- 11 -------- 12 -------- 13 -------- 14 -------- 15 -------- 16 -------- 17 -------- 18 -------- 19 -------- 20 -------- 21 -------- 22 -------- 23 -------- 24 -------- 25 -------- 26 -------- 27 MYLRE--- 28 -------- 29 -------- 30 -------- 31 -------- 32 -------- 33 LFKYEPH- 34 -------- 35 MYEEPQ-- 36 -------- 37 -------- 38 -------- 39 -------- 40 -------- 41 -------- 42 -------- 43 MYSRPS-- 44 -------- 45 -------- 46 -------- 47 -------- 48 -------- 49 -------- 50 -------- 51 -------- 52 -------- 53 -------- 54 -------- 55 -------- 56 -------- 57 -------- 58 -------- 59 IE------ 60 -------- 61 -------- 62 -------- 63 -------- 64 -------- 65 -------- 66 -------- 67 -------- 68 -------- 69 -------- 70 -------- 71 -------- 72 -------- 73 -------- 74 --------