; SAM: prettyalign v3.1b (February 24, 1999) compiled 04/18/00_11:44:15 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ------ Citations (HMMs, SAM) ------ ; A. Krogh et al., Hidden Markov models in computational biology: ; ------------- Citations (SAM, SAM-T99, HMMs) ----------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; -------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 gi|4104516|gb|AAD02056.1|_63:230 ; 2 gi|541428|pir||S41759_129:297 ; 3 gi|1723586|sp|P45558|PRMA_CLOAB_129:297 ; 4 gi|1825535|gb|AAC44876.1|_59:237 ; 5 gi|1575549|gb|AAC44619.1|_62:240 ; 6 gi|7478388|pir||B70614_47:224 ; 7 gi|1575546|gb|AAC44616.1|_47:224 ; 8 gi|516113|gb|AAA87622.1|_6:184 ; 9 gi|530212|gb|AAB16936.1|_30:210 ; 10 gi|532249|gb|AAA65210.1|_31:212 ; 11 gi|7800670|gb|AAF70111.1|AF257324_12_32:213 ; 12 gi|2916809|emb|CAA12014.1|_31:212 ; 13 gi|7517797|pir||A75217_4:200 ; 14 gi|6166151|sp|O14321|ERG6_SCHPO_99:278 ; 15 gi|7443714|pir||T42375_45:224 ; 16 gi|6015114|sp|O74198|ERG6_CANAL_97:273 ; 17 gi|6598836|gb|AAF18691.1|AC010795_6_178:381 ; 18 gi|7518112|pir||D75063_134:303 ; 19 gi|7518704|pir||E71168_137:306 ; 20 gi|7416784|dbj|BAA94033.1|_197:383 ; 21 gi|6321023|ref|NP_011102.1|_25:193 ; 22 gi|7380059|emb|CAB84640.1|_140:291 ; 23 gi|7226471|gb|AAF41613.1|_115:245 ; 24 gi|1169553|sp|P45438|ERMK_BACLI_27:114 ; 25 gi|477038|pir||A47697_27:114 ; 26 gi|730032|sp|Q04720|ERMJ_BACAN_27:114 ; 27 gi|1169552|sp|Q03986|ERMD_BACLI_27:114 ; 28 gi|7470360|pir||S74478_16:256 ; 29 gi|3776564|gb|AAC64881.1|_55:298 ; 30 gi|2281316|gb|AAC45501.1|_11:188 ; 31 gi|7490350|pir||T40404_15:219 ; 32 gi|6324814|ref|NP_014883.1|_119:324 ; 33 gi|7292119|gb|AAF47531.1|_5:216 ; 34 gi|7023954|dbj|BAA92136.1|_116:278 ; 35 gi|6841182|gb|AAF28944.1|AF161384_1_179:341 ; 36 gi|7106072|emb|CAB76043.1|_69:265 ; 37 gi|3075397|gb|AAC14529.1|_47:258 ; 38 gi|4731342|gb|AAD28459.1|AF127374_14_30:221 ; 39 gi|3025151|sp|P76290|YECO_ECOLI_3:242 ; 40 T0092 ; 41 gi|1175220|sp|P43985|YECO_HAEIN_1:241 ; 42 gi|7449894|pir||D64568_2:242 ; 43 gi|7449893|pir||F71861_2:242 ; 44 gi|6968057|emb|CAB75226.1|_1:235 ; 45 gi|7481052|pir||T37021_15:216 ; 46 gi|1632838|emb|CAA64854.1|_16:217 ; 47 gi|6319738|ref|NP_009820.1|_42:205 ; 48 gi|3183316|sp|O13748|YDRE_SCHPO_45:162 ; 49 gi|7407189|gb|AAF61950.1|AF237633_1_16:165 ; 50 gi|7291819|gb|AAF47239.1|_119:250 ; 51 gi|7481048|pir||T34921_173:340 ; 52 gi|6967798|emb|CAB72791.1|_37:233 ; 53 gi|7429749|pir||C64705_47:244 ; 54 gi|538899|pir||B48653_37:225 ; 55 gi|1346175|sp|P49016|GRCB_LACLA_37:225 ; 56 gi|7674095|sp|O86169|MENH_BACST_28:228 ; 57 gi|7474059|pir||F75277_46:222 ; 58 gi|7480087|pir||T36753_20:176 ; 59 gi|7473566|pir||C75569_31:199 ; 60 gi|6136578|sp|Q55423|Y829_SYNY3_31:191 ; 61 gi|6434718|emb|CAB61165.1|_43:197 ; 62 gi|7672273|emb|CAB89463.1|_189:360 ; 63 gi|6968616|emb|CAB73437.1|_139:314 ; 64 gi|7451049|pir||F69198_18:167 ; 65 gi|2128868|pir||C64481_13:122 ; 66 gi|7299975|gb|AAF55147.1|_235:348 ; 67 gi|7486450|pir||T05192_50:168 ; 68 gi|2126366|pir||I40649_65:229 ; 69 gi|7469807|pir||S76919_21:132 ; 70 gi|7491567|pir||T40101_33:198 ; 71 gi|2495889|sp|Q57732|Y284_METJA_9:108 ; 72 gi|6094425|sp|P76145|TAM_ECOLI_16:139 ; 73 gi|7471497|pir||D75520_17:131 ; 74 gi|7519075|pir||A71001_10:142 ; 75 gi|7433474|pir||F69472_15:96 ; 76 gi|7416806|dbj|BAA94055.1|_44:153 ; 77 gi|7470129|pir||S77194_37:159 ; 78 gi|3088592|gb|AAC14722.1|_48:142 ; 79 gi|2121206|pir||I76774_47:152 ; 80 gi|7496331|pir||T33109_13:128 ; 81 gi|1175329|sp|P44074|Y912_HAEIN_8:150 ; 82 gi|7298756|gb|AAF53967.1|_38:173 ; 83 gi|7514524|pir||D70359_31:166 ; 84 gi|7516544|pir||H72630_34:150 ; 85 gi|6015918|emb|CAB57745.1|_17:113 ; 86 gi|7445263|pir||C75155_13:143 ; 87 gi|7484088|pir||T08338_198:354 ; 88 gi|6491814|emb|CAB61860.1|_72:225 ; 89 gi|7490910|pir||T38024_23:164 ; 90 gi|7479391|pir||T34740_28:205 ; 91 gi|2829568|sp|P71779|YE98_MYCTU_2:151 ; 92 gi|1890588|emb|CAB01936.1|_58:240 ; 93 gi|141450|sp|P20187|YT37_STRFR_101:279 ; 94 gi|5902658|gb|AAD55585.1|_154:326 ; 95 gi|1076062|pir||JC4099_89:270 ; 96 gi|730914|sp|P39896|TCMO_STRGA_161:322 ; 97 gi|1170276|sp|P46597|HIOM_HUMAN_184:345 ; 98 gi|7521702|pir||C75210_6:141 ; 99 gi|7518537|pir||C71246_6:142 ; 100 gi|7688721|gb|AAF67508.1|AF170880_15_8:175 ; 101 gi|7471558|pir||E75511_1:180 ; 102 gi|7491966|pir||T41554_22:187 ; 103 gi|7303243|gb|AAF58305.1|_66:222 ; 104 gi|3758823|emb|CAA09857.1|_37:184 ; 105 gi|7462981|pir||E72392_6:199 ; 106 gi|7470235|pir||S74397_19:177 ; 107 gi|1771204|emb|CAA68045.1|_12:184 ; 108 gi|7511552|pir||T18571_301:458 ; 109 gi|2073517|emb|CAA72463.1|_64:177 ; 110 gi|6226396|sp|O05979|Y789_RICPR_64:177 ; 111 gi|2495672|sp|Q57060|Y095_HAEIN_1:189 ; 112 gi|7469840|pir||S76978_57:219 ; 113 gi|3724043|emb|CAA04312.1|_202:363 ; 114 gi|6692724|gb|AAF24830.1|AC012679_1_56:230 ; 115 gi|7407189|gb|AAF61950.1|AF237633_1_249:428 ; 116 gi|543890|sp|P36571|BIOC_SERMA_30:159 ; 117 gi|2506982|sp|P12999|BIOC_ECOLI_27:193 ; 118 gi|145427|gb|AAA23517.1|_27:193 ; 119 gi|7328463|dbj|BAA92862.1|_11:218 ; 120 gi|7496359|pir||T33131_11:222 ; 121 gi|7190742|gb|AAF39525.1|_27:237 ; 122 gi|7445290|pir||D71516_16:227 ; 123 gi|7483336|pir||F69255_255:427 ; 124 gi|729153|sp|Q06528|CM4T_STRPE_142:321 ; 125 gi|530214|gb|AAB16938.1|_142:321 ; 126 gi|7495376|pir||T33771_54:216 ; 127 gi|7509432|pir||T26511_112:343 ; 128 gi|7509433|pir||T26512_115:346 ; 129 gi|7467445|pir||T17439_1162:1298 ; 130 gi|408802|gb|AAA27636.1|_1156:1292 ; 131 gi|1346305|sp|P48633|HMP2_YEREN_1156:1292 10 20 30 40 50 | | | | | 1 -VVKPLWEEYTPKDYEL...MLNMDPGMAFGT-------GTHETTRMCIQALE.RYVNED.AE.. 2 IVVKPLWEEYTPKDYEL...MLNMDPGMAFGT-------GTHETTRMCIQALE.RYVNED.AE.. 3 IVVKPLWEEYTPKDYEL...MLNMDPGMAFGT-------GTHETTRMCIQALE.RYVNED.AE.. 4 -----------------...--------------------------VDLNLDK.LDLKPG.MT.. 5 -----------------...--------------------------VDLNLDK.LDLKPG.MT.. 6 -----------------...---------------------AQLAKVDLALDK.LNLEPG.MT.. 7 -----------------...---------------------AQLAKVDLALDK.LNLEPG.MT.. 8 -----------------...-------------------------MGRRLVDI.SEPVTG.ER.. 9 -----------------...-----------------------TPMGRRLVDI.SEPVTG.ER.. 10 -----------------...------------------------PMGRPLVEI.SEPVTG.ER.. 11 -----------------...-------------------------MGRRLVER.AAPAAG.AR.. 12 -----------------...------------------------PMGLRLVDH.ADPRPG.QR.. 13 --------EELYKYLRW...RMDPEDKRAVER--------FHRIVEVFEKLKD.SKLISG.SR.. 14 FYKGEAFAQSIARHEHY...-----------------------------LAYR.MGIKPG.SR.. 15 FYKGEAFAQSIARHEHY...-----------------------------LAYR.MGIKPG.SR.. 16 YYKGEAFRQATARHEHF...-----------------------------LAHK.MNLNEN.MK.. 17 ---------------RF...FELIGSNEQFAEMFNRAMSEASTLIMKKVLEVY.KGFEDV.NT.. 18 ------------DFWDL...RLSSSFNKIYRD----------------VIVNL.GEINRE.SY.. 19 ------------DFWDI...RLSSSFNKTYRD----------------AIINL.GEIRED.SY.. 20 -----------------...----------------KLMTASQPLVAREVIAA.YRFGRH.KV.. 21 -----------------...--------------------------FYKMIDE.YHDGER.KL.. 22 -----------------...-------------------------EYLDLLAH.APSTGF.QT.. 23 -----------------...-------------------------EYLDLLAH.APSTGF.QT.. 24 MHNKKLIEEIVDRANIS...I--------------------------------.-----D.DT.. 25 MHNKKLIEEIVDRANIS...I--------------------------------.-----D.DT.. 26 MHNKKLIEEIVDRANIS...I--------------------------------.-----D.DT.. 27 MHNKKLIEEIVDRANIS...I--------------------------------.-----D.DT.. 28 -MTTPLEKKSTIEDIRS...RFDKDVARFSSLETGQATTIDAPLAMSLITEAA.ISCTKNiRH.. 29 -HSRHSSGKFFKVLHTH...HYSISCNQLLSFTIEEKFELVERRYLLKEFPEL.VSCGEN.SK.. 30 -RESENFYDRIASQFDH...SFDGFLASFFKR----------------FILKN.LKFEQN.SK.. 31 ------YKKESKKSWDK...FYKRNETRFFKD----RHWLDREFDCYFGLPDK.L----P.LT.. 32 EFDKKLYNENPARYWDI...FYKNNKENFFKD------RKWLQIEFPILYAST.RKDAEP.VT.. 33 --QKERFQTDAPKFWDS...FYGIHDNRFFKD----RHWLFTEFPELAPLAAD.SAVLQP.RS.. 34 -----------------...---------------------------------.-----T.YR.. 35 -----------------...---------------------------------.-----T.YR.. 36 VTEKDAYMTHPERYWDQ...FYGKNEGKFFMN----RRWIAQEFPELLDLLKE.--DAGE.KS.. 37 -TNTDKYERDAKKYWDI...FYKHHGDRFFKD----------RHYLDKEWNSY.FSVSGK.SV.. 38 --------------GAA...SLGENLHFGYWDSPDSQVPLAEATDRLTDMMAErLRIGAG.SR.. 39 -HRDTLFSAPIARLGDW...TFDERVAEVFPDMIQRSVPGYSNIISMIGMLAE.RFVQPG.TQ.. 40 MVKDTLFSTPIAKLGDF...IFDENVAEVFPDMIQRSVPGYSNIITAIGMLAE.RFVTAD.SN.. 41 MVKDTLFSTPIAKLGDF...IFDENVAEVFPDMIQRSVPGYSNIITAIGMLAE.RFVTAD.SN.. 42 --KDTLFNESLNK--RF...CFDEKVAHVFDDMLERSIPYYHEMLNLGAYFIA.QNLKEN.IYpk 43 --KDTLFNESLNK--RF...CFDEKVAHVFDDMLERSIPYYHEMLNLGAYFIA.QNLKEN.VYhk 44 MMKDELFKQSPKK--QF...EFDKSVASVFDDMINRSVPFYRENLELCGNLLA.KILPTN.AS.. 45 -----------------...----HASHTYDGLTALNPGYRTGLLRSARRLAL.PADGAG.LH.. 46 -----------------...-----GSTAYDRLVSASPGYHAHLRRSARRLGL.PEEGRG.LR.. 47 -----------------...----------------DVLGSNNFLRKLKSRML.PQENNV.KY.. 48 -----------------...--------------------------LNRLNYR.IGKIEN.LV.. 49 --------------KKY...WIEHSVDLTVEAMMLDSQASDLDKVERPEVLSM.LPPYEG.KS.. 50 -----------------...--------------------------------M.EEPPDR.LH.. 51 -----------------...---------------------QPLVEEA-IART.LDRNAP.VR.. 52 -----------------...--------------------------ACQRVMS.LYLKKD.LK.. 53 -----------------...------------------------------FLF.LENKKA.LR.. 54 -----------------...--------------------QHDLWRAKTMKRM.GDLT-G.LS.. 55 -----------------...--------------------QHDLWRAKTMKRM.GDLT-G.LS.. 56 -----------------...------------------SFRRHLKWRKDVMRR.MNVQKG.KK.. 57 -----------------...----------RR----------------AAAAE.ALAHSP.RR.. 58 -----------------...-------ASFDDEPDHGLRDAEVRRAWAARLAS.WLPAPP.GD.. 59 -----------------...-------------------------AALALAAA.LDVPPT.GR.. 60 -----------------...-------ERFHQ----------------LPLEN.LAISPG.QK.. 61 -----------------...----------------------KTHRRSLEWLL.ARLAPG.SR.. 62 -----------------...-------------------------KLELVSRK.LDLSPG.RR.. 63 --NNTLYEAQINKIEH-...-----------------------------TLKK.LDLKEG.EK.. 64 -----------------...-----------------------RLAA--FREA.ISSRAR.GL.. 65 -----------------...----------------SLLTDYERLAIFKNAIE.RVVDED.DV.. 66 -----------------...-----------------------------LLQN.EAVVRG.KT.. 67 -----------------...------------------------AMLALSCER.AKVEDG.QS.. 68 -----------------...-----------------------------AAYL.LKLENN.QT.. 69 -----------------...-----------------------------LVSV.ANQIPQ.GK.. 70 -----------------...---------------------------------.--LFYE.AS.. 71 MMLDSLKRHPNPKADLE...QYTIDGKLAADI-----------------LFFA.VNDFYN.NV.. 72 -----------------...----------------------RSRPAVELLAR.VPLENV.EY.. 73 -----------------...------------------------APARDLQAL.IPERPY.AQ.. 74 ------------EYYDT...IYRRRIERV-----------KAEIDFVEEIFKE.DAKREV.RR.. 75 -----------------...-----------------------RRVISRIVGY.AELSED.DV.. 76 -----------------...--------------------GRDRMRTTLLSWL.PQDLRG.RR.. 77 LYEGSLVTARYRRDGKV...IT-------------------------------.--DLEN.RV.. 78 -----------------...-------------------------------GR.KPSTDN.IR.. 79 -----------------...-------------------------------LS.RALGRP.LN.. 80 -----------------...-------------AQQKWLYQDHLVLPTLEKLL.KYNLKD.KK.. 81 -YDKDNFFELYQKLRA-...----------------NPISLNEIIEKPTMLSL.LPNLKG.KK.. 82 -----------------...---------------------------------.-----G.QN.. 83 -----------------...-------------------------LVLFLSKI.KPPKRN.YR.. 84 -----------------...------------------------ELIPKILEL.LDLKED.DV.. 85 -----------------...--------------------------VRRMLEI.AKASQD.DI.. 86 -----------------...-------RTYDEDVEREDWIHADYEEVLKLVAE.RV---G.GT.. 87 -----------------...---------FAA---------------------.--MAPG.ET.. 88 -----------------...--------------------------------I.PPALEG.AT.. 89 -----------------...--------------------AWRTPETCSTYML.KYVKKT.DR.. 90 -----------------...---EN----------------------SAAYLL.GSLRPH.MR.. 91 -----------------...---------------------------------.------.--.. 92 -----------------...-------------------------FLGHFILL.GGVRPE.SR.. 93 -YLDQLATTDAARSYKS...V----------------------------MLDA.LDARPG.ES.. 94 -----------------...----------------DHMDTFNQFVVAELSKA.LDWSRW.KT.. 95 -------YEDLDRARQI...MLH---------------MDAHNGFTADELARA.IDWSRY.TS.. 96 -----------------...-----------------------------LAGA.LDWTEY.SS.. 97 -----------------...---------------------------------.------.--.. 98 -----------------...-----YYRAFPTYTDINSQEYRDRLENLEPLLM.KYMKRR.GK.. 99 -----------------...-----YYRVFPTYTDINSQEYRSRIETLEPLLM.KYMKKR.GK.. 100 -----------------...---GSEAEAFHRMGSQASHRYDEFVDLLVGAGI.A---DG.QT.. 101 MMTDAWNAEQYRDRHAF...VFQSSEDLAAEW---------------------.LRPQPG.ER.. 102 -----------------...--------------------------TKDIVKR.INLSSS.DE.. 103 ------------RVFDI...---------------------------------.--KREF.KA.. 104 -----------------...---------------------SSPWLCNRMAGL.ADWTQA.TT.. 105 --KYDRFAALYDKFESF...IEKKFFSRFREELFKR-----------------.---VEG.KK.. 106 -----------------...-------QTYQQLVDHNYMAHRQIHQAVGALIQ.QQFDRP.FD.. 107 MMNRPVVKAELVEWMRSsqtQVTGELAEVLNFAKENNIPVIPHETVLY-FQML.LSLLKP.KR.. 108 ------QYKKIDR----...-----------------------------LIDQ.LELKAD.DH.. 109 -----------------...------------------------------GIN.APEVEN.SK.. 110 -----------------...------------------------------GIN.APEVEN.SK.. 111 MAKDEVGHNFLARLGKT...RLRPGGKKATDW-----------------LIAN.GGFSQD.KK.. 112 -----------------...---------------------------------.--LGNK.SK.. 113 -----------EESPVW...PLGIEDDEFIQRKPDKGLITKKEIRTL--SISA.LQLKRD.SV.. 114 -----------------...-------LRYERVFGEGFVSTGGLETTKEFVDM.LDLKPG.QK.. 115 -----------------...-YKFNSILRYERVFGPGYVSTGGLETTKEFVSK.LDLKPG.QK.. 116 -----------------...---------------------LQRDVGERLLGM.GSSHPG.EQ.. 117 -----------------...----------------------QRQSADALLAM.LPQRKY.TH.. 118 -----------------...----------------------QRQSADALLAM.LPQRKY.TH.. 119 -----------------...----------GGLFEDFTQSAAQAIEVRTIFHM.IGDVSG.KS.. 120 -----------------...------------EAQQKWLGRDHLITPTIKKAF.GHILVG.KE.. 121 -----------------...--------LAPTYDKINKILSLGLHLTWNHSFV.SLLGRS.DH.. 122 -----------------...-------SLAPTYDKINGILSLGLHIAWNNALV.SLLGET.NH.. 123 -----------------...----------YFLFEEKFRGSRELVKARLRRYI.PYFKGC.RR.. 124 FYEDLAGRPDLRASFDS...LLACDQDVAFDA-----------------PAAA.YDWTNV.RH.. 125 FYEDLAGRPDLRASFDS...LLACDQDVAFDA-----------------PAAA.HDWTNV.RH.. 126 LYEDDDVEELVERDELS...RTYCPVCSSRDTVPLNFISHSLSRLQVKFLFDL.LMPPTC.QH.. 127 YFNKKYRYGNFDRYYGI...RLNPGESDKRLS------------------VFQ.KDWFEH.KQ.. 128 YFNKKYRYGNFDRYYGI...RLNPGESDKRLS------------------VFQ.KDWFEH.KQ.. 129 -----------------...---------------ASAPYIQELATICQQLAQ.R-LQRP.VR.. 130 -----------------...---------------ASAPYIQELATICQQLAQ.R-LQRP.VR.. 131 -----------------...---------------ASAPYIQELATICQQLAQ.R-LQRP.VR.. 60 70 80 90 100 | | | | | 1 ......VFDIGTGSGILAIAAAK...L---NAKKVLGVDLDSVAVKAAKENI.......QYNN.V 2 ......VFDIGTGSGILAIAAAK...L---NAKKVLGVDLDSVAVKAAKENI.......QYNN.V 3 ......VFDIGTGSGILAIAAAK...L---NAKKVLGVDLDSVAVKAAKENI.......QYNN.V 4 ......LLDIGCGWGTTMRRAVE...RL---DVNVIGLTLSKNQHARCEQVL.......ASID.T 5 ......LLDIGCGWGTTMRRAVE...RF---DVNVIGLTLSKNQLARCEQVL.......ASID.T 6 ......LLDVGCGWGGALVRAVE...KY---DVNVIGLTLSRNHYERSKDRL.......AAIG.T 7 ......LLDVGCGWGGALVRAVE...KY---DVNVIGLTLSRNHYERSKDRL.......AAIG.T 8 ......VLDIGCGRGACLFPAAE...KVG-SQGCVHGIDIAPGMIEEARKEA.......TERG.L 9 ......VLDIGCGRGACLFPAAE...KVG-SQGCVHGIDIAPGMIEEARKEA.......TERG.L 10 ......VLDIGCGRGACLFPAAE...KVG-PQGRVHGIDIAPGMIEEARKEA.......AERG.L 11 ......VLDVGCGRGACVFPAAE...RVG-PEGRVVGIDVAEAMIEEATKEA.......ALRD.A 12 ......VLDVGCGRGACLFPAAR...RVA-PDGYALGIDIAPAMVEEAAAEA.......ERLG.M 13 ......VLDICAGTGIAGVALAK...VL--NAKKLTVLDVRREDLDKVEKWM.......EVAG.I 14 ......VLDVGCGVGGPAREITE...FT---GCNLVGLNNNDYQISRCNNYA.......VKRN.L 15 ......VLDVGCGVGGPAREITE...FT---GCNLVGLNNNDYQISRCNNYA.......VKRN.L 16 ......VLDVGCGVGGPGREITR...FT---DCEIVGLNNNDYQIERANHYA.......KKYH.L 17 ......LVDVGGGIGTIIGQVTS...KY--PHIKGINFDL--------ASVL.......AHAP.F 18 ......VLDLGCGSVSPSYFGKF...IS--EDGKYLGVDYSPGLLEIARQRV.......EREG.L 19 ......ILDLGCGSVSPAYFGKF...IS--EDGKYVGVDYSPGLLEIARERV.......ERNG.L 20 ......LMDVGGGEGAFVRCVAA...EV--PGVELRVFDL-PAVAERANENF.......QRWG.L 21 ......LVDVGCGPGTATLQMAQ...ELK-PFEQIIGSDLSATMIKTAEVIK.......EGSP.D 22 ......AFDIGTGSGVLAAILAK...Q---GIPSVIGTDTNPKAVACARANI.......ARLG.F 23 ......AFDIGTGSGVLAAILAK...Q---GIPSVIGTDTNPKAVACARANI.......ARLG.F 24 ......VLELGAGKGALTTMLSQ...K----AGKVLAVENDSKFVAILTRKT.......AQHP.- 25 ......VLELGAGAGALTTVLSQ...K----AGKVLAVENDSKFVDILTRKT.......AQHS.- 26 ......VLELGAGKGALTTVLSQ...K----AGKVLAVENDSKFVDILTRKT.......AQHS.- 27 ......VLELGAGKGALTTVLSQ...K----AGKVLAVENDSKFVDILTRKT.......AQHS.- 28 ......VLDIGCGAGNNTLRLRQ...SAN-YDFNVDLLDLSAPMLMKAAERV.......QQLN.R 29 ......LLEIGCGNGSTVLPILR...GS--KNITVYACDCSSDALVRTKENId......RAIS.S 30 ......ILDIGCANGKLLAMLND...K---KKIVGSGLDISSEMIKVAKAQY.......P---.- 31 ......ILEVGCGVGNLVYPLLE...VQ--PNLKIYCCDFSPRAIDFVKKHS.......CYNE.N 32 ......IFEIGCGAGNTFFPILK...DNENENLRIIAADFAPRAVELVKNSE.......QFNP.K 33 ......IFELGCGVGNTILPLLQ...YSSEPQLKVFGCDFSARAIEILRSQR.......QFDE.K 34 ......ILEVGCGVGNTVFPILQ...TNNDPGLFVYCCDFSSTAIELVQTNS.......EYDP.S 35 ......ILEVGCGVGNTVFPILQ...TNNDPGLFVYCCDFSSTAIELVQTNS.......EYDP.S 36 ......ILEIGCGAGNTIWPILK...ENKNSNLKIFAVDYSEKAIDVVKQNP.......LY-D.A 37 ......ILEVGCGAGNTIFPLIA...TY--PDIFVYACDFSPRAVELVKAHD.......EYTE.T 38 ......VLDLGCGVGTPGVRIAR...L---SGAHVTGISVSHEQVVRANALA.......EEAG.L 39 ......VYDLGCSLGAATLSVRR...NIHHDNCKIIAIDNSPAMIERCRRHI.......DAYK.A 40 ......VYDLGCSRGAATLSARR...NINQPNVKIIGIDNSQPMVERCRQHI.......AAYH.S 41 ......VYDLGCSRGAATLSARR...NINQPNVKIIGIDNSQPMVERCRQHI.......AAYH.S 42 slpkplIYDLGCSTGNFFIALNR...QIQ-QEIELVGIDNSMPMLKKAQEKL.......KDFN.- 43 slpkplIYDLGCSTGNFFIALNQ...QIQ-QDIELVGIDNSMPMLKKAQEKL.......KDFN.- 44 ......VCDLGCSSANFLIFLAN...LR--KDFKLFGVDNSASMLEVAKSKA.......KAYG.L 45 ......LLDLGCGTGASTRALLR...AA--PRARITAVDASAGMLRRALVK-.......-PWP.A 46 ......VLDLGCGTGASTAALLA...AA--PRARITGVDASAGMLDRATAKS.......WPQG.- 47 ......AVDIGAGIGRVSKTMLH...KH---AAKIDLVEPVKPFIEQMHVEL.......AELK.D 48 ......AADCGAGIGRVTENVLL...KI---ASHVDLVEPVENFISTAKKQL.......A---.- 49 ......VLELGAGIGRFTGELAE...K----ASQVIALDFIESVIKKNESIN.......GHYK.- 50 ......VLDVGSCFNPFSSA---...----PHLEVTALDLCPATEDVLQADF.......LKVE.V 51 ......LLEVGCGSGTYVRYAAE...LN--PRLSALAVDLQQDVADSAAANM.......AEWG.L 52 ......IADIACGTGDMIEIWQEsalKMEKNILNIKGIDPSSGMLNVAKEKF.......P---.- 53 ......LVDVACGTGDMLVAWQKsalNCGIEFKECLGIDPSNNMLELAIKKC.......EELE.N 54 ......ILDLCCGTGDWTFDLSE...SVG-PSGKVIGLDFSENMLEIAKAKL.......KEEA.K 55 ......ILDLCCGTGDWTFDLSE...SVG-PSGKVIGLDFSENMLEIAKAKL.......KEEA.K 56 ......ALDVCCGTADWTIALAE...AVG-PEGKVYGLDFSENMLKVGEQKV.......KARG.L 57 ......VLDVATGTGDFAIELKE...RA--PQVEIVGSDFVPQMLDLARQKA.......GAKQ.L 58 ......VLDLGCGTGSLSLLAAE...Q----GHRVTGVDLSPAMVELARTKL.......AGRD.- 59 ......VLDVATGTGTVALTLAP...K----VAEVMGTDIAPAMIEQARQRA.......AGRS.- 60 ......VLDLCCGGGQATVYLAQ...S----GATVVGLDASPKALGRAKINV.......P---.- 61 ......VLDVGSGTGRPTAETLA...GA---GHEVLGVDVSPVMVELAARQV.......P---.- 62 ......LLDVGCGWGSMAIHAAR...EH---GVSVVGVTLSQEQAAYARKRV.......ADEG.L 63 ......LLDIGCGWGWLSIMAAQ...KY---GVKVVGITISEEQCKKAKERV.......KELG.L 64 ......TYDLGAGSGILSFFASE...Y----ADRVIAIERDPKIAACAGENL.......SGLD.- 65 ......VFDLGTGSGILAMIAAK...K----AKKVYAIELDPFTYDYAKENI.......KVNG.F 66 ......VLDVGCGTGILSIFASK...A---GAARVVGIDN-SDIVYTAMDII.......RKNK.V 67 ......VLDIGCGWGSLTLYIAR...KY--SKCKLTGICNSKTQKAFIDEKC.......RKLG.L 68 ......VLDACAAPGSKTSHILE...VNP-HLKTLVAIDNNKQRLNRIKENI.......TRLG.L 69 ......ILCLAEGEGRNACFLAS...L----GYEVTAVDQSSVGLAKAKQLA.......QEKG.V 70 ......VLDIGCNNGTVSAQIAS...IF--GASFVLGLDIDHVLIQKARKHL.......E---.- 71 ......VIDLGCGTGRLAIGSKI...L---GAKRAIGIDIDRESIEAAKENA.......KKLN.V 72 ......VADLGCGPGNSTALLQQ...RW--PAARITGIDSSPAMIAEARSAL.......P---.- 73 ......VVDLGCGTGEQTAQLAQ...RF--PQATVLGLDSSAAMLAKAGAQ-.......-QLP.- 74 ......VLDLACGTGIPTLELAE...R----GYEVVGLDLHEEMLRVARRKA.......KERN.L 75 ......VLEVGCGTGNLTSALLR...K-----CSVVGIEKDPLMVKRLRERF.......SDFI.G 76 ......VLDAGCGTGAASIELAR...R----GAEVVAIDLSPTLVGYARERL.......PESL.G 77 ......MLDVACGTGATTLTMAL...AN--PGAKVVGIDISPESIKIAEERL.......QYHK.I 78 ......ILDAGCGTGVGTEYLIH...LN--PAAEIVGIDLSEGALEVAEKRC.......QQSG.V 79 ......VLDLGCAQGFFSLSLAS...K----GATIVGIDFQQENINVCRALA.......EENP.D 80 ......VLDIGCGNGLNSTTFLQ...W---GARKVVGFDNSQEMIENCKNLH.......KSSE.- 81 ......LLDLGCGTGGHLQLYLE...R---GAAKVIGTDLSEKMLEQAEKDL.......QKCGqF 82 ......ILEVGCGGGLLTEHLAR...L----GAQVAGIDLGEKLIEAAREHL.......KCSS.P 83 ......IIDLGAGFGFLSITLAK...KY---GVKVVAFEYDERMVKLLRKNV.......KLNG.V 84 ......FYDLGCGDGRVVIEAVK...KT--RVKKAVCVETRDDLVKEARKKA.......EEEG.V 85 ......VYDLGCGDGRIIITAVK...DF--NVKKAIGVEINDERIREALANI.......EKNG.V 86 ......VVDIGCGTGNILCFL--...----KCERYIGVEPSRGMRAKFKEKH.......GFEP.L 87 ......VLDLGSGAGFDCFLAAQ...EVG-PDGHVIGVDMTPEMISKARENV.......AKND.A 88 ......VLDLGSGSGRDVYVLSQ...LVG-PTGRVIGVDMTEEQLAVARRHQdwha...ERFG.H 89 ......ILDVGCGPGTITVGFPK...YV--PEGEVIGVEPSQELLDKAEEALrkeetl.KKEK.I 90 ......ILDIGCGPGTITADLAE...RV--PEGHVTGVDRSPEIVERARATA.......AARG.L 91 ......-LDVGCGSGRMALPLTG...YLN-SEGRYAGFDISQKAIAWCQEHI.......TSAH.P 92 ......VLDIGCGIGRMAVPLTQ...YLDFEKGHYSGIDPVEGGIGWCRRFI.......TSVY.P 93 ......ALDLGCGPGTDLGTLAK...AVS-PSGRVIGIDSSQEMVEQARRRT.......ENLP.- 94 ......FVDVGGARGNVAAQLVL...DH--PDLKGSVFDV-PGVEPLFDEHM.......AARG.T 95 ......FVDVGGGRGNVASRIVT...AH--PHLRGGVFDL-PALRPLFEELV.......ASAG.T 96 ......FVDLGGARGNLAAHLHR...AH--PHLRATCFDL-PEMEPFFQEHM.......KSLE.T 97 ......-CDLGGGAGALAKECMS...LY--PGCKITVFDI-PEVVWTAKQHF.......SFQE.E 98 ......VLDLACGVGGFSFLLED...Y----GFEVVGLDISEEMISKAKMYA.......KEKS.S 99 ......VLDLACGVGGFSFLLED...Y----GFEVVGVDISEDMIRKAREYA.......KSRE.S 100 ......VVDLCCGSGELEVILSS...RF--PSLNLVGVDLSEDMVRIAREYA.......AEQG.K 101 ......ILDLGCGSGELTARIAQ...S----GAQVVGVDASPAMIAAAQSSF.......P---.- 102 ......LLDLGCGDGVLTNELVS...Q----CRRVVGIDASPDMIKAAREL-.......-GLN.A 103 ......AADIGCSRGYLSRHILA...E---SVEQLTLTDTSATMLEQAQGTP.......G---.L 104 ......VAELGAGDGVLTRRLLD...RMA-PDTQLDAWEIQPELVGQLRSLA.......EHDH.- 105 ......ILEVGIGTGKNVPYYS-...----DDMDVVGVDISEGMLRVCQERL.......KKFP.E 106 ......FLDLGCGDAQAIAKTLT...GS--KINSYTGVDLSPNALALAQKNL.......DPFR.- 107 ......ILEIGTAIGFSALVMAQ...EV--PEAEIVTIDRNPEMIELAKKNL.......AKYD.H 108 ......VLEIGCGWGAAAIRAVQ...R---SGCKWTGITISKEQLEWGQKKV.......VEAG.L 109 ......ILELGCAAGGNLIPHAV...LY--PNAHFVGVDLSKVQIDEANKNV.......RALG.L 110 ......ILELGCAAGGNLIPHAV...LY--PNAHFVGVDLSKVQIDEANKNV.......RALG.L 111 ......VLEVACNMGTTAIGLAK...QF---GCHIEGVDLDENALAKAQANI.......EANG.L 112 ......VLYVGVGGGLEALQFAY...FCR-QPGAVIAVDPVEAMRQAAQRNLqlaaeknDWFS.V 113 ......VWDIGTCTGSVAIEAAK...IA--REGQIFAVEKNEADLENCRENL.......AKFR.V 114 ......VLDVGCGIGGGDFYMAE...NF---DVDVVGIDLSVNMISFALEH-.......-AIG.L 115 ......VLDVGCGIGGGDFYMAE...NY---DVEVVGIDLSINMISFALER-.......-SIG.L 116 ......LLDAGCGTGYFSRMWRE...R----GKRVTALDLAPGMLDVARQRQ.......A---.- 117 ......VLDAGCGPGWMSRHWRE...R----HAQVTALDLSPPMLVQARQKD.......AADH.- 118 ......VLDAGCGPGWMSRHWRE...R----HAQVTALDLSPPMLVQARQKD.......AADH.- 119 ......VLDLACGFGFFGREIYR...R---GAAKVVGVDISEKMIELAREES.......RKYG.D 120 ......VLDVGCGNGHYSFDFLR...W---GAHKVFGVDNSEEMIQICKSSP.......DFEN.F 121 ......LLDLCAGTGHVALSYIQ...KY--PQASATLVDFSTKMLENVQECH.......PLAP.- 122 ......LLDLCAGTGRVALSYVQ...NY--PRASATLVDFSTKMLENVQKRH.......PSAP.- 123 ......VLDIGCGRGEFLELCKE...E----GIESIGVDINEDMIKFCEGKF.......NVVK.S 124 ......VLDVGGGKGGFAAAIAR...RA--PHVSATVLEM-AGTVDTARSYL.......KDEG.L 125 ......VLDVGGGKGGFAAAIAR...RA--PHVSATVLEM-AGTVDTARSYL.......RDAG.L 126 ......VLDIGSRLGAIVYGASI...FTN-GNVSTIGVEMDSDYAALALRTI.......RQFG.L 127 ......ALDIGCNAGFLTLSIAK...DF--SPRRIIGIDIDEHLIGVARKNI.......RHYC.- 128 ......ALDIGCNAGFLTLSIAK...DF--SPRRIIGIDIDEHLIGVARKNI.......RHYC.- 129 ......LLEVGTRTGRAAESLLA...QLNAGQIEYVGLEQSQEMLLSARQRL.......APWP.G 130 ......LLEVGTRTGRAAESLLA...QLNAGQIEYVGLEQSQEMLLSARQRL.......ASWP.G 131 ......LLEVGTRTGRAAESLLA...QLNAGQIEYVGLEQSQEMLLSARQRL.......ASWP.G 110 120 130 140 | | | | 1 N.-NI....EILHGNLME........VVQ........GKADII....VANIIADVIN-....--- 2 N.-NI....EILHGNLME........VVQ........GKADII....VANIIADVIN-....--- 3 N.-NI....EILHGNLME........VVQ........GKADII....VANIIADVIN-....--- 4 N.RSR....QVLLQGWED........FA-........EPVDRI....VSIEAFEHFGH....ENY 5 N.RSR....QVLLQGWED........FA-........EPVDRI....VSIEAFEHFGH....ENY 6 Q.RRA....EARLQGWEE........FE-........ENVDRI....VSFEAFDAFKK....ERY 7 Q.RRA....EARLQGWEE........FE-........ENVDRI....VSFEAFDAFKK....ERY 8 R.-NI....SLMVMDAET........PGFpa......RSFDLV....MGSYSVIFLP-....-DA 9 R.-NI....SLMVMDAET........PGFpa......RSFDLV....MGSYSVIFLP-....-DA 10 R.-NI....ALDVMDAET........PELpa......RSFDLV....MGSYSVIFLP-....-DA 11 A.-MV....ELRVMDGEH........PDFap......HSFDVV....LGSYSVIFLP-....-DA 12 P.-HV....EVRVMDGER........PALpe......RSFERV....LGSYSVIFFP-....-EA 13 D.VEV....EKIVGDAKK........VGElve.....EHDVAV....LFGLTMPHFNA....FDA 14 D.KKQ....VFVKGDFMH........MPFed......NTFDYV....YAIEATVHAP-....-SL 15 D.KKQ....VFVKGDFMH........MPFed......NTFDYV....YAIEATVHAP-....-SL 16 D.HKL....SYVKGDFMQ........MDFep......ESFDAV....YAIEATVHAP-....-VL 17 N.KGV....EHVSGDMFK........-EI........PKGDAI....FMKWILHDWTD....EDC 18 -.-PV....ELKEMDVSL........IKPr.......TKYDVA....IMSFLLEYVK-....-DR 19 -.-PA....ELKEMDVSL........IRTr.......SKYDVA....IMSFLLEYVR-....-DR 20 A.GRA....QAFGGDFFA........DELp.......RGADVI....SLVRVAFDHPD....ERV 21 TyKNV....SFKISSSDD........FKFlgadsvdkQKIDMI....TAVECAHWF--....-DF 22 E.KQV....EIRETDLFPegf13ppwLPA........KPTSAV....ESALYDPESA-....-ML 23 E.KQV....EIRETDLFPegf13ppwLPA........KPTSAV....ESALYDPESA-....-ML 24 -.-NT....KIIHQDIMK........IHLpk......EKFVVV....SN---------....--- 25 -.-NT....KIIHQDIMK........IHLpk......EKFVVV....SN---------....--- 26 -.-NT....KIIHQDIMK........IHLpk......EKFVVV....SN---------....--- 27 -.-NT....KIIHQDIMK........IHLpk......EKFVVV....SN---------....--- 28 G.-LV....RTIQGDFRS........VSLpn......STYDVL....IAAAVLHHLRDd...EDW 29 V.DNF....HSFCCDFSTsef27eskH--ci......GGVDFV....TLIFTLSAVPK....ERM 30 -.-YF....TFEQGSAQE........IPFdn......ESFDLI....ICSASFHHFP-....-KP 31 -.-RV....FPFVNDITE........DSLlevlgs..ACIDTL....TAIFVLSAIPR....EKQ 32 -.-YG....HATVWDLAN........PDGnlpdgvepHSVDIA....VMIFVFSALAP....NQW 33 -.-RC....EVFVMDATL........DHWqvpfee..NSQDII....VMIFVLSAIEP....KKM 34 -.-RC....FAFVHDLCD........EEKsypvpk..GSLDII....ILIFVLSAIVP....DKM 35 -.-RC....FAFVHDLCD........EEKsypvpk..GSLDII....ILIFGLSAIVP....DKM 36 K.-FC....SASVWDLAG........SDLlrsiee..ASIDAI....TLIFCFSALSP....DQW 37 -.-RV....CAFACDLTG........DGLdkhisp..SSVDIV....TMIFVLSAVSP....EKM 38 A.DRA....RFQRADAMD........LPFed......ESFDAV....IALESIIHMP-....-DR 39 P.TPV....DVIEGDIRD........IAI........ENASMV....VLNFTLQFLEP....SER 40 E.IPV....EILCNDIRH........VEI........KNASMV....ILNFTLQFLPP....EDR 41 E.IPV....EILCNDIRH........VEI........KNASMV....ILNFTLQFLPP....EDR 42 -.-NA....RFECMDFLE........VEF........KEASAF....SLLFVLQFVRP....MQR 43 -.-NV....RFECMDFLE........VKF........KEASAF....SLLFVLQFVRP....MQR 44 -.-DI....SFFEANLCE........FDF........FTCDVF....VANYTMQFIRP....PKR 45 -.-RV....RFLHLTAEE........FATtrede...GPFDAV....FAAYLFRNVT-....-DP 46 -.--V....DFVHLPVEE........LAGrlea....GSFDAV....FAGYLFRNLT-....-DP 47 K.GQIg...QIYEVGMQD........WTPda......GKYWLI....WCQWCVGHLPD....AEL 48 T.KPC....SFINVGLQN........WTPek......NRYGLI....WNQWCLSHLTD....EDL 49 -.-NV....KFMCADVTS........PSLnisp....NSVDII....FSNWLLMYLSD....EEV 50 V.PGIrep.ELEEGSVRR........LPA........SHYECV....IFSLLLEYMPSa...EQR 51 T.DRV....ETRQADLRT........LDAq.......PQFDLV....TLHNNIYYFPE....AER 52 -.-NV....EFIKAGAQN........LPLes......QSLDIL....SISYGIRNVV-....-ER 53 -.-KA....SFIQAQAKD........LKGven.....NSVDIL....SIAYGLRNVV-....-ER 54 K.-NI....EFLQGNAMA........LPFek......GSFDVV....TIGYGLRNTP-....-DY 55 K.-NI....EFLQGNAMA........LPFek......GSFDVV....TIGYGLRNTP-....-DY 56 H.-NV....KLIHGNAMQ........LPFpd......NSFDYV....TIGFGLRNVP-....-DY 57 -.-SI....RFEEGDALR........LPYpd......ASFDAV....TCAFGFRNFA-....-DY 58 -.--A....VFLTGDAAA........PPVge......QRFDAV....LVRHVLWTLP-....-DP 59 -.-NV....QFVLAEATA........LTFad......QSFDVV....VCGAGLFFVP-....-DM 60 -.-QA....TYVQGLAED........LPFge......GEFDLV....HTSVALHEMTP....AQL 61 -.-AA....TFRCADIRD........VPLad......ESFDAV....CVYFSLLQLDR....AEQ 62 T.DRV....EIRVQDYRD........VAD........GPYDAI....SSIGMAEHVGA....ERY 63 E.DKI....EIRLQNYQD........LEFe.......NYFDKV....VSVGMFEHVGK....ENL 64 -.-NV....SVVNEDALH........YEF........SAADTI....ICEMLDTALID....EEQ 65 N.-NI....EIIEGDAST........YNFk.......EKADVV....IAELLDTALII....EPQ 66 E.-NV....ELIKGRLED........TDLpe......TKYDII....ISEWMGYFLLY....ESM 67 Q.-NV....EIIAADIST........FEHe.......GTYDRI....FSIEMFEHMK-....-NY 68 -.-RQ....EHLQCLLADvsq45isq---........------....-------YHQ-....-KK 69 -.-KI....TTVQSNLAD........FDIva......DAWEGI....VSIFC--HLPS....SLR 70 -.-FV....SSRIGPVRNpgs49flrWESk.......RKFKIIlalsVSKWVHLNNHD....EGI 71 -.-DV....DFYCMDIRDvdd.....---........------....-----------....--- 72 -.-DC....QFVEADIRN........WQPv.......QALDLI....FANASLQWLP-....-DH 73 -.-NL....RFEQGDIQE........LS-........GSFDLL....YSNAALQWLP-....-DH 74 -.-KI....EFLQGDVLE........IAFk.......NEFDAV....TMFFSTIMYFDe...EDL 75 K.GRF....RLIQGDALK........VDF........PYFTK-....-----------....--- 76 P.GSI....DFRSGDMLD........PAL........GRFDHV....IAMDSVIHYDA....PDA 77 D.-NS....EFHVLALED........LDQlg......QKFDYI....SASDILYLLP-....-DL 78 R.DRHtapvTFKRLPIEQ........ATEle......GEFDLI....NCVGVLHHMP-....-D- 79 F.-AA....EFRVGRIEE........VIAalee....GEFDLA....IGLSVFHHIVHlhgiDEV 80 -.-QS....SFHHLNVTD........FQLd.......EKFHVA....TAVFVLQYVHDk...EEL 81 S.GRF....SLYHLPIEK........LAElpe.....SHFDVI....TSSFAFHYIE-....-NF 82 E.-LA....SNVVYKIEP........VDQhakanc..ECYDAV....IVSEVLEHVK-....-DK 83 E.HLV....EVVEGDIKE........IEKhlsr....GSFNLV....VSNPPFYPINYs...PNP 84 S.DRI....EFINNDFFK........TPL........KDATAV....YMYLLTSVNE-....--- 85 T.GRA....SIVKGNFFE........VDI........SEATVV....TMF--------....--- 86 D.---....----GHFLS........IPLld......GTADAV....ISTYTFHHVPD....EEK 87 E.-NV....EFRLGEIGH........LPVad......ESVNVV....ISNCVVNLAP-....-EK 88 A.-NT....DFRHGYIED........LAGagipd...ASVDVV....VSNCVVNLSP-....-DK 89 N.-NC....SFRLGSIYK........LPFpd......NTFDIV....NTHQVLVHLQ-....-DP 90 E.-NT....GFAVADVHA........LDYpd......DTFCVV....HAHQVLQHVG-....-DP 91 -.-NF....QFEVSDIYNsly15dfrFPYpd......ASFDVV....FLTSVFTHMFP....PDV 92 -.-NF....AFQRVDIAHely15alkLPYad......GHFDFV....IMTSIVTHLPP....DEV 93 -.-AV....EVELGDIHT........LPLed......GSIDCA....RTDRVLQHVA-....-DP 94 T.GRV....DFVGGDFFT........DAL........PAADVV....LFGHVLHDHPE....ESR 95 A.DRV....DFHGGDFFA........TDL........PEADVV....IFGHVLPDWPV....GDR 96 T.DQV....RFAGGDFFT........DPL........PRADVF....IVGHILHYFGL....RQR 97 E.-QI....DFQEGDFFK........DPL........PEADLY....ILARVLHDWAD....GKC 98 -.-NV....EFIIGDAKK........LPFed......NNFDYV....IFIDSLVHFSP....LEL 99 -.-NV....EFIVGDARK........LSFed......KTFDYV....IFIDSIVHFEP....LEL 100 -.-AL....EFRHGDAQL........LAGmedla...GKADLV....VSRNAFHRLT-....-RL 101 -.-AV....PFEVQDAHA........LTFg.......SEFEAV....FSNAALHWMK-....-PL 102 Y.VIP....GEKLLDASE........IPS........ESFDVV....FSNAALHWIMRqp..KNR 103 -.-KM....VKLVKDEEQ........LDFed......NSLDLV....ISSLSLHWVN-....-DL 104 -.-RL....QVISRSAER........LE-........RHYDVI....FSCLPLLSIPV....IPR 105 K.-KV....KLLRADVQN........LPFsd......GEYDCV....VSTFVFCTVP-....-DP 106 -.-QV....ELRETDFLT........YLGeanqtap.ASFDLI....HVGFSLHHLLP....EEK 107 R.NQI....QLKEGDAAD........VLQelk.....GPFDLV....FMDSAKS----....-KY 108 E.GRI....ELKFQDYRL........VK-........EKYTRV....VSIEMIEAVGE....KYL 109 K.-NI....EFHHCSITD........IDDsf......GKFDYI....ICHGVISWVPK....IVR 110 K.-NI....EFHHCSITD........IDDsf......GKFDYI....ICHGVISWVPK....IVR 111 Q.EKI....HVQRANAMK........LPFed......ESFDIV....INEAMLTMLPV....EAK 112 D.-FV....DIRAGDAFT........LPVpd......NSVDVV....AQNCLFNIFEP....EDL 113 -.-DA....HTVHGKAPE........GLNef......ADPDAV....FIGGTAG----....-GM 114 K.CSV....EFEVADCTK........KEYpd......NTFDVI....YSRDTILHIQ-....-DK 115 K.CAV....EFEVADCTK........KDYpe......NSFDVI....YSRDTILHIQ-....-DK 116 -.-AH....HYLLGDIEQ........VPLpd......AAMDIC....FSSLVVQWCS-....-DL 117 -.---....-YLAGDIES........LPLat......ATFDLA....WSNLAVQWCG-....-NL 118 -.---....-YLAGDIES........LPLat......ATFDLA....WSNLAVQWCG-....-NL 119 -.-PL....EFHVRDVAN........MEPl.......GQFDLV....NAAWLFNYADSv...ENL 120 N.SKI....DFLLGEVTN........FHVdg......ASFDVA....TAFFVLQFLHKn...DDV 121 -.--F....SYVISDVTS........MPLpn......DTFHLA....SMAYGLRNLS-....-SP 122 -.--F....SYITSDVTH........LPLpd......NTFRLA....SMAYGLRNLS-....-YP 123 D.-AI....EYLKS----........LPD........KYLDGV....MISHFVEHLDP....ERL 124 S.DRV....DVVEGDFFE........PLP........RKADAI....ILSFVLLNWPD....HDA 125 S.DRV....DVVEGDFFE........PLP........RRADAI....ILSFVLLNWPD....HDA 126 K.-NI....EILRDDIRH........LAHvf......KDNQFI....VMNNVFSFFLSk...TEQ 127 -.-DH....ETEVSGKFPasf42demLDMiq......PEFDVIlalsITKWIHLNWGD....DGM 128 -.-DH....ETEVSGKFPasf42demLDMiq......PEFDVIlalsITKWIHLNWGD....DGM 129 A.-RL....SLWNADTLA........AHA........HSADII....WLNNALHRLLP....EDP 130 A.-RL....SPWNADTLA........AHA........HSGDII....WLNNALHRLLP....EDP 131 A.-RL....SPWNADTLA........AHA........HSGDII....WLNNALHRLLP....EDP 150 160 170 180 | | | | 1 -ILIPDINK........FLKTDGYFI----...-.----.---.....---.....--------- 2 -ILIPDINK........FLKTDGYFI----...-.----.---.....---.....--------- 3 -ILIPDINK........FLKTDGYFI----...-.----.---.....---.....--------- 4 DDFFKRCFN........IMPADGRMTVQSS...V.SYHP.YEM.....AAR.....GKKLSFETA 5 DDFFKRCFN........IMPADGRMTVQSS...V.SYHP.YEM.....AAR.....GKKLSFETA 6 LTFFERSYD........ILPDDGRMLLHSL...F.TYDR.RWL.....HEQ.....GIALTMSDL 7 LTFFERSYD........ILPDDGRMLLHSL...F.TYDR.RWL.....HEQ.....GIALTMSEL 8 VGALARYAD........ILDHGGRIAFTSP...V.FRAG.TFPflp..PEF.....TPLIPQALL 9 VGALARYAD........ILDHGGRIAFTSP...V.FRAG.TFPflp..PEF.....TPLIPQALL 10 VGALARYAG........ILDHGGRIAFTSP...V.FRAG.TFPflp..PEF.....TPLIPQALL 11 PTALARYAP........LLSPGGRLAFTSP...V.FSDD.TFPflp..PVF.....TELIPRELL 12 LPALVRYAG........LLADGGRIAFTSP...V.FTED.TFPflp..PVF.....TELIPRSLL 13 VKLFAGVAS........ILSENGVFILEE-...-.--TD.RVY.....GIM.....YLVGYKDFL 14 EGVYGEIFR........VLKPGGVFGVYEW...V.MSDD.YDS.....---.....--------- 15 EGVYGEIFR........VLKPGGVFGVYEW...V.MSDD.YDS.....---.....--------- 16 EGVYSEIYK........VLKPGGIFGVYEW...V.MTDK.YDE.....---.....--------- 17 VKILKNYWK........SLPEKGKVIIVEV...V.TPEE.PKIndissNIV.....FGMDMLMLA 18 REVLRKVLE........ALDSGGKLVIVDA...F.RDEF.KNI.....EAM.....--------- 19 EEVLGKVLE........ALDSGGKLIIVEA...F.RDEF.ENI.....QAM.....--------- 20 LTLFKNVRR........ALPDNGTLVLAEA...-.MAEV.PGV.....EPI.....GDAYFGFYL 21 EKFQRSAYA........NLRKDGTIAIWGY...A.DPIF.PDY.....---.....--------- 22 AAFLRDAPK........HLNPDGEIRLIIS...D.LAEH.LH-.....---.....--------- 23 AAFLRDAPK........HLNPDGEIRLIIS...D.----.---.....---.....--------- 24 ---------........-------------...-.----.---.....---.....--------- 25 ---------........-------------...-.----.---.....---.....--------- 26 ---------........-------------...-.----.---.....---.....--------- 27 ---------........-------------...-.----.---.....---.....--------- 28 RQAFQKIYN........LLAPGGSVWITDL...V.SHEQ.PAV.....QAM.....MWDRYGDYL 29 PRAIKECFA........VLKPGGLLLFRDY...G.LYDM.TML.....---.....--------- 30 ERFLLEAEC........LLSPNGRLVIAEI...H.IPFI.TK-.....---.....--------- 31 LRSIKNLAS........VIKPGGHLVFRDY...C.DGDF.AQE.....K--.....-------FM 32 DQAMDNLHK........ILKPGGKIIFRDY...G.AYDL.TQV.....---.....--------- 33 QRVLDNCYR........YLRPGGLLLFRDY...G.RYDL.AQL.....---.....--------- 34 QKAINRLSR........LLKPGGMVLLRDY...G.RYDM.AQL.....---.....--------- 35 QRAINRLSR........LLKPGGMMLLRDY...G.RYDM.AQL.....---.....--------- 36 QQAIENLYR........LLKPGGLILFRDY...G.RLDL.TQL.....---.....--------- 37 SSVLQNIRK........VLKPNGCILFRDY...A.VGDL.AQE.....---.....--------- 38 AQVLAQVGR........VLRPGGRLVLTDF...F.ERAP.LAP.....---.....--------- 39 QALLDKIYQ........GLNPGGALVLSEK...F.SFED.AKV.....GEL.....LFNMHHDFK 40 IALLTKIYE........GLNPNGVLVLSEK...F.RFED.TKI.....NHL.....LIDLHHQFK 41 IALLTKIYE........GLNPNGVLVLSEK...F.RFED.TKI.....NHL.....LIDLHHQFK 42 EVLLKKIYN........SLALNGVLLVGEK...I.MSED.RIL.....DKQ.....MIELYYLYK 43 EVLLKKIYN........SLALNGVLLVGEK...I.MSED.RIL.....DKQ.....MIELYYLYK 44 QELLDQIYK........NLNSKGILIMSEK...I.LYED.AFL.....SKN.....IIELYADYK 45 DAVLRAVRQ........LLRPGGRFAAHEY...S.LSGS.PGH.....RAL.....WSAVCRGVV 46 DEALDMLHG........LLVPGGRLAVHEY...T.LGGS.PVH.....RAV.....WSAVCSLII 47 VAFLKRCIV........GLQPNGTIVVKEN...N.TPTD.TDDf....---.....--------- 48 IAYLSRCCE........AIQEKGVICVKEN...V.S---.---.....---.....--------- 49 ERLVERMLK........WLKPGGYIFFRES...C.FH--.---.....---.....--------- 50 LQCCLQAYD........LLLPEGILVLITP...D.SQHV.GKN.....AHL.....MKNWRYSLA 51 VEALRRAHD........LLAPGGRLLLTTS...C.KGGN.VGL.....EAL.....--------- 52 QKALSEFAR........VLQKDGILVVLEF...T.KREK.GGF.....IAA.....CRDFYLKNI 53 QEALKEFFR........VLKPRGVLVILEF...LkKDNP.TWL.....DKI.....SGFYTNKVL 54 LTVLKEIFR........VLKPGGRVVCIET...S.HPTL.PIY.....KQA.....FELYFKNVM 55 LTVLKEIFR........VLKPGGRVVCIET...S.HPTL.PIY.....KQA.....FELYFKNVM 56 MTVLKEMHR........VTKPGGITVCLET...S.QPTL.FGF.....RQL.....YYFYFRFIM 57 TQGLAEMWR........VLTPGGRLVLLEF...P.PPAS.GLF.....GAV.....FRLYFQHVL 58 GRALRHWRQ........LLRPGGRLVLVEG...V.WGSV.SPV.....GIP.....ADRVTALLG 59 VAALREWRR........VLRPGGEVVFSAF...G.RGLL.GPL.....---.....--------- 60 QSIISGVHR........VLKPGGIFALVDL...H.RPSN.WLF.....WPP.....LAIFMGLFE 61 KDLVRRLVR........LLRPGGHLVLATV...P.L---.---.....---.....--------- 62 LEYATDLHR........LLKPGGRLLNHQI...A.RRPQ.RDE.....SSY.....NVDEFIDAY 63 GLYFMKVKQ........VLKPGGSMLLHSI...L.AMFE.GKT.....N--.....--------- 64 VPVLRRALK........FLRNDGTVIPQAV...F.NAAE.PVT.....---.....--------- 65 VKVMN----........-------------...-.----.---.....---.....--------- 66 LDSIIYAREn.......HLNPNGIILPS--...-.----.---.....---.....--------- 67 GELLKKIGN........WMKEDSLLFVHYL...-.----.---.....---.....--------- 68 LQLLNALWT........VLKAGGFLLYSTC...S.VLPD.ENE.....KVI.....EEFLSTHDK 69 QQLYPKVYQ........GLKPGGVFILEGF...-.----.---.....---.....--------- 70 IKFFGKISS........LLETNGVLILEPQ...G.WDSY.LKA.....---.....--------- 71 ---------........-------------...-.----.---.....---.....--------- 72 YELFPHLVS........LLNPQGVLAVQMP...D.NWLE.PTH.....---.....--------- 73 PRLLARLWE........HLRPGGVLAVQVP...A.N---.---.....---.....--------- 74 RKLFSKVAE........ALKPGGVFI----...-.----.---.....---.....--------- 75 ---------........-------------...-.----.---.....---.....--------- 76 VAALSRLAE........-------------...-.----.---.....---.....--------- 77 TLALQQLRA........ILKPDGII-----...-.----.---.....---.....--------- 78 ---------........-------------...-.----.---.....---.....--------- 79 KRLLSRLAD........-------------...-.----.---.....---.....--------- 80 RKAIRLIW-........-------------...-.----.---.....---.....--------- 81 PTLLSTIHD........KLSSNGTLIFS--...-.----.---.....---.....--------- 82 VSLLEASVR........SLKPGGSIFITTL...N.KTIP.SWF.....GGV.....LLSEYVLNL 83 EPYHFEVYAtlk11ssyLLKDGGELYLLSP...C.----.---.....---.....--------- 84 -SLKPKLAR........ELRDGTRIVTLDF...P.----.---.....---.....--------- 85 --LLTNVNE........MLKP---------...-.----.---.....---.....--------- 86 EDAIKEMLR........VLNPGGRIVIADV...M.FESE.---.....---.....--------- 87 QRVFDDTYR........VLRPGGRVAISDV...V.QTAP.FPD.....DVQ.....MDPD----- 88 PRVLSEIFR........VLKPGGELYFSDI...-.-FSD.RRL.....PAS.....LLDDPVLVG 89 VAALVELKR........VTKPGGYVCCKEA...D.LLSA.CVY.....PKE.....Y-------- 90 VRALREMRR........VARPGGFIAVRDS...D.YGAM.TWY.....PASsgmddWLDLYHRVA 91 EHYLDEISR........VLKPGGRCLC-TY...F.LLND.ESL.....AHI.....AEGKSAHNF 92 LVYLREVGR........LLKPGGRLFMTAF...V.VDHV.AAA.....---.....--------- 93 AQALAEARR........VLRPGGRLVMGEP...D.WDSL.TID.....---.....--------- 94 KRLLGQAFR........ALPPGGTLLVYDA...M.LDDR.SEA.....GAY.....LQSLVCSVI 95 RELLRRAHK........AVRPGGLVVLYDA...M.IDPE.ERD.....PEV.....LLQR----- 96 EALIARIHQ........ALTPGGAVLVYDR...M.IDDD.RRS.....AAL.....SLLGSLNML 97 SHLLERIYH........TCKPGGGILVIES...L.LDED.RRG.....PLL.....TQLYSLNML 98 NQVFKEVKR........VLKPTGKFIIY--...-.----.---.....---.....--------- 99 NQVFKEVRR........VLKPSGKFIMY--...-.----.---.....---.....--------- 100 PAAFDTMLR........LAKPGGAVLNCSF...I.HPSD.FDE.....SGF.....RAWVTFLNQ 101 PPVFGRVAA........ALKPGGRFVLEMG...G.AGNVqTTL.....DAV.....AHATHKLGL 102 PIVMKGVSR........VLRTKGRFV-AEC...G.AFGN.VSE.....VVG.....SIYSILLAL 103 PGCFVRIKQ........SLKPDGVFIASMF...G.GDTL.YEL.....---.....--------- 104 LRILNRVRE........RLNPGGVFIQFQY...S.PLSE.KLL.....SRY.....FEWTRVYEV 105 VKGLKEVHR........VLRPSGKAVFLEH...M.RSRK.WYV.....NVI.....LFLMHIFTK 106 EQFFAHCFS........LLRPGGCLVIYDV...F.RQPE.QNR.....QQY.....IEAYL---- 107 VEFLPKSLE........LLSENGLILMDDV...F.QAGE.ILL.....PIM.....--------- 108 PQYFQIIND........VLTDGGIAALQAI...T.CPDA.YYD.....QYR.....SSSDFIKKY 109 DKIFKVCNR........NLSTNGIAYIS--...-.----.---.....---.....--------- 110 DKIFKVCNR........NLSTNGIAYIS--...-.----.---.....---.....--------- 111 KKAIAEYFR........VLKPNGLLLTHDV...M.LVGN.DHQ.....TIL.....--------- 112 SRALKEAYR........VLKPHGRLIMSDP...I.A-AR.PIP.....QHL.....RQDERLRAM 113 ETILDVCCS........RLNSGGRIVL---...-.----.---.....---.....--------- 114 PALFRRFYK........WLKPGGKVLITDY...C.RSPK.TPS.....---.....--------- 115 PALFRSFHK........WLKPGGKVLISDY...C.KSAG.TPS.....---.....--------- 116 PAALAELYR........VTRPGGVILFSTL...A.AGSL.QEL.....GDA.....WQQ------ 117 STALRELYR........VVRPKGVVAFTTL...V.QGSL.PEL.....HQA.....WQAVDE--- 118 STALRELYR........VVRPKGVVAFTTL...V.QGSL.PER.....HQA.....WQAVDE--- 119 RKMFKVVRA........SLKPDGKLVAYTVdpdF.SLAK.GNF.....AKY.....GVNVLNERA 120 ALAIQNISR........HLKSRGTFFGLIP...N.GVPG.VRA.....PEN.....MGLKLGAQI 121 LEALKEVHR........VLKPKGRLGILEL...T.RPAT.YNP.....VHL.....LHKLYLNLV 122 LEALREVYR........VLQPGGHLGILEL...T.RPAT.YNP.....VYL.....LHKLYLNLV 123 FELLSLCYS........KMKYSSYIVIESP...N.PTSL.YSL.....---.....--------- 124 VRILTRCAE........ALEPGGRILIHER...D.DLHE.NSF.....NEQ.....FTELDLRML 125 VRILTRCAE........ALEPGGRILIHER...D.DLHE.NSF.....NEQ.....FTELDLRML 126 EECWEFLHT........HMRPGTVLAHH--...-.----.---.....---.....--------- 127 RRFFRRAYA........QLHPGGRLIIEPQ...A.FDSY.KKR.....AKM.....--------- 128 RRFFRRAYA........QLHPGGRLIIEPQ...A.FDSY.KKR.....AKM.....--------- 129 -GLLATLQQ........LAVPGALLYVMEF...R.QLTP.SAL.....---.....--------- 130 -GLLATLQQ........LAVPGALLYVMEF...R.QLTP.SAL.....---.....--------- 131 -GLLATLQQ........LAVPGALLYVMEF...R.QLTP.SAL.....---.....--------- 190 200 210 220 230 | | | | | 1 ......----.----..---..-----...-SSGIIKDRAEDVIENLK.KNKFEIIE-------- 2 ......----.----..---..-----...-SSGIIKDRAEDVIENLK.KNKFEIIE-------- 3 ......----.----..---..-----...-SSGIIKDRAEDVIENLK.KNKFEIIE-------- 4 ......RFIK.----..---..FIVTE...IFPGGRLPSTEMMVEHGE.KAGFTVPEPLSLRPH- 5 ......RFIK.----..---..FIVTE...IFPGGRLPSTEMMVEHGE.KAGFTVPEPLSLRPH- 6 ......RFLK.----..---..FLRES...IFPGGELPSEPDIVDNAQ.AAGFTIEHV------- 7 ......PIPQ.----..---..ILRES...IFPGGELPSEPDIVDNAQ.AAGFTIEHV------- 8 ......EHLP.EQWR..PEA..LVRRF...NSWLER---AEDLVRTLE.GCGYA----------- 9 ......EHLP.EQWR..PEA..LVRRF...NSWLER---AEDLVRTLE.GCGYA----------- 10 ......EHLP.EQWR..PEA..LVRRF...NSWLER---AEDLLRTLE.RCGYTSV--------- 11 ......LDLP.PQWQ..PEQ..LQQRF...NSWLAD---PRDLTRTLE.RCGFQEVT-------- 12 ......DTLP.PDWR..PEA..LRRRF...NSWLER---PDDLEATMR.RAGFGEV--------- 13 ......VETK.GKDY..TLI..SVHEG...YDPVKGVFKRTYYKLP--.---------------- 14 ......--SI.PKHR..EIA..YNIEV...GDGIPQMVRKCDAVEAIK.KVGFNLLE-------- 15 ......--SI.PKHR..EIA..YNIEV...GDGIPQMVRKCDAVEAIK.KVGFNLLE-------- 16 ......--TN.EEHR..KIA..YGIEV...GDGIPKMYSRKVAEQALK.NVGFE----------- 17 ......VSSG.GKER..SLS..QFE--...--------------TLAS.DSGFLRCEIICHAFSY 18 ......----.----..--E..FFEGL...NSSFVGYPGKEEVKRIIL.EEGF------------ 19 ......----.----..--E..FFESL...NRSFVGYPAKAEIKKAIL.REGF------------ 20 ......LAMG.----..---..-----...---RGRPRSAARLTQMLH.EAGFASVRPLSTHMPL 21 ......PEFD.DLMI..EVP..YGKQG...LGPYWEQPGRSRLRNMLK.D--------------- 22 ......----.----..---..-----...------LRPSDFLDKAFA.QAG------------- 23 ......----.----..---..-----...------------------.---------------- 24 ......----.----..---..-----...------------------.---------------- 25 ......----.----..---..-----...------------------.---------------- 26 ......----.----..---..-----...------------------.---------------- 27 ......----.----..---..-----...------------------.---------------- 28 ......VSLG.GAEY..R-D..KVFGY...IDREDSPRPVTYQLDLLR.SVGFDAVDLLHKNSCF 29 ......RFEP.EKRV..GFR..EYVRS...DGTLSYFFCLDTARKLFT.DAGFIEVELEYCC--- 30 ......----.--IY..NWW..INRFS...TEGDVKVYQPKELTELFN.QNGWK----------- 31 ......TSGD.PSMI..DEQ..TFVRQ...DGTLSLFFREEDIAEWMK.SAGFGLVT-------- 32 ......RFKK.NRIL..EEN..FYVRG...DGTRVYFFSEEKLREIFT.---------------- 33 ......RFKS.GKCM..EDN..FYVRG...DGTMVYFFTEEELRGMMT.QAGLQEEQ-------- 34 ......RFKK.GQCL..SGN..FYVRG...DGTRVYFFTQEELDTLFT.TAGLEKVQ-------- 35 ......RFKK.GQCL..SGN..FYVRG...DGTRVYFFTQEELDTLFT.TAGLEKVQ-------- 36 ......RAKK.NRIL..SEN..FYIRG...DGTRVLIVNRK-------.---------------- 37 ......RFSGkDQRI..SEN..FYVRG...DGTRAFYFSNEFLETLFS.EQGFEVEELDVCCK-- 38 ......----.--EG..RAA..VQRYL...HDFMMTMVSAEAYPPLLR.GAGLWLEE-------- 39 ......RANG.YSEL..EIS..QKRSM...LENVMLTDSVETHKARLH.NAGFEHSELWFQCFNF 40 ......RANG.YSEL..EVS..QKRTA...LENVMRTDSIETHKVRLK.NVGFSQVELWFQCFNF 41 ......RANG.YSEL..EVS..QKRTA...LENVMRTDSIETHKVRLK.NVGFSQVELWFQCFNF 42 ......QNQG.YSHN..EIA..FKREA...LENVLVPYSLKENVALLE.SVGFKHVEALFKWVNF 43 ......QNQG.YSHN..EIA..FKREA...LENVLVPYSLKENIALLE.SVGFKHVEALFKWVNF 44 ......EKQG.YSKF..EIA..AKREA...LENVLIPYSQKENLNMLE.KAGFKKIESIFKWANF 45 ......IPAG.TLTG..DRT..LYRHL...RRSVVAFDTAPEFAARLT.RAGLTSVR-------- 46 ......QPAG.RLTG..DAG..LYRHL...RDSVTRFDTAPAFAQRLR.RAGFADVRVL------ 47 ......----.----..---..--DE-...-TDSSVTRSDAKFRQIFE.EAGLK----------- 48 ......----.----..---..-----...------------------.---------------- 49 ......----.----..---..-----...------------------.---------------- 50 ......----.----..---..-----...------------------.---------------- 51 ......----.----..--N..LWFTY...ADFGGPLPQADALADQLR.QAGFDDVEA------- 52 ......LPSI.GGIIskNKS..AYEYL...PNSIEGFLSKKEFILELK.NAGFEMLDYKSFSFGV 53 ......PLVG.GAISk.NYG..AYSYL...PQSIEGFLSLEGLKHELR.NAGFEILRTEDSIAQI 54 ......PFLG.KVFAk.SLK..EYQWL...QKSAEDFPDAKTLEELFR.KAGFVAVEYQ------ 55 ......PFLG.KVFAk.SLK..EYQWL...QKSAEDFPDAKTLEELFR.KAGFVAVEYQ------ 56 ......PLFG.KLLAk.SYE..EYSWL...QESAREFPGRDELAEMFR.AAGFVDVEVKPYTFGV 57 ......PRIG.ALVSg.NAG..AYTYL...PESVLAFPEPERLAQMMR.ATGFR----------- 58 ......PLTG.Q---..---..-----...------------------.---------------- 59 ......PGLW.RERL..AGE..GVKPG...APPLGRIGTVEAAKDLLI.QAGFAEVTAELT---- 60 ......TETA.WQLI..N--..-----...----------TDLGSLLD.QAGFTVVR-------- 61 ......----.-DVE..GVD..ATFMG...QPVRVTSFPAQELIALAE.EAGLEV---------- 62 ......VFPD.GELA..P--..-----...---------VGTTVTQLE.RAGFEVRDVESIREH- 63 ......----.----..--A..WIDKY...IFPGGYLPSLREVVSAMS.EWDFHLLLAESLR--- 64 ......VNFE.NIMY..DEN..LSQPS...SGPMRVYDRVE-------.---------------- 65 ......----.----..---..-----...------------------.---------------- 66 ......----.----..---..-----...------------------.---------------- 67 ......----.----..---..-----...------------------.---------------- 68 ......VEL-.----..---..-----...------------------.---------------- 69 ......----.----..---..-----...------------------.---------------- 70 ......----.----..---..-----...------------------.---------------- 71 ......----.----..---..-----...------------------.---------------- 72 ......----.----..---..-----...------------------.---------------- 73 ......----.----..---..-----...------------------.---------------- 74 ......----.----..---..-----...------------------.---------------- 75 ......----.----..---..-----...------------------.---------------- 76 ......----.----..---..-----...------------------.---------------- 77 ......----.----..---..-----...------------------.---------------- 78 ......----.----..---..-----...------------------.---------------- 79 ......----.----..---..-----...------------------.---------------- 80 ......----.----..---..-----...------------------.---------------- 81 ......----.----..---..-----...------------------.---------------- 82 ......VPRG.THHW..---..-----...------------------.---------------- 83 ......----.----..---..-----...------------------.---------------- 84 ......----.----..---..-----...------------------.---------------- 85 ......----.----..---..-----...------------------.---------------- 86 ......----.----..---..-----...------------------.---------------- 87 ......----.----..---..---SL...TGCVAGASTVDDLKAMLD.EAGFEAVEI------- 88 ......ECLA.GALY..T--..-----...----------EDFRRAL-.---------------- 89 ......----.----..---..-----...------------------.---------------- 90 ......RANG.----..---..-----...----GEPDAGRRLKAWAL.EAGFTDITATSATWTF 91 ......QHEG.PGYR..TIH..K----...------------------.---------------- 92 ......NESG.RRDA..RLS..FARDG...DGPCWYVPDMPRLAAVGF.DDGF------------ 93 ......--YP.DLEV..SRA..YTRHV...TDKIVRNGVIGRQLARLAlDAGFAVP--------- 94 ......LDGG.SEYR..---..-----...---------VRDITAWAE.ETGFTVEQ-------- 95 ......----.----..---..INHTM...IRDEAGAYSLQEARAYLE.EAGFT----------- 96 ......LTSD.E---..---..-----...----GREYTPAECVRWLS.DAGFTDVR-------- 97 ......VQTE.GQER..T--..-----...---------PTHYHMLLS.SAGFRDFQFKKTGAIY 98 ......----.----..---..-----...------------------.---------------- 99 ......----.----..---..-----...------F-----------.---------------- 100 ......RPWD.SEMQ..---..-----...------------------.---------------- 101 ......PELP.PPWV..---..-----...------FPTAGELCTGLE.AAGMRVE--------- 102 ......GATK.EQID..QAN..PWF--...------FGSEDDYTRMLE.EAGF------------ 103 ......-RSS.LQLA..ELE..RKGGI...SPHISPFTQIRDIGSLLN.RAGFTML--------- 104 ......RNIP.PAW-..---..-----...------------------.---------------- 105 ......LLLG.TSML..---..-----...----------RKTVDNIK.KAGFVIEEEKYLLSDV 106 ......----.----..---..A----...------------------.---------------- 107 ......----.----..---..-----...------------------.---------------- 108 ......IFPG.GHLP..SLG..AISQS...L-----------------.---------------- 109 ......----.----..---..-----...------------------.---------------- 110 ......----.----..---..-----...------------------.---------------- 111 ......----.----..--E..NMRKA...INVTVTPLTKDGWKGIFQ.ESGFRNVD-------- 112 ......CLSG.----..---..-----...------ALTYAEYIQHLI.DTGFGQIEI------- 113 ......----.----..---..-----...--NAVTIENLAEAMKAFK.ERGFE----------- 114 ......----.----..-PD..FAIYI...KKRGYDLHDVQAYGQMLR.DAGFEEV--------- 115 ......----.----..-AE..FAAYI...RQRGYDLHDVKAYGKMLK.DAGFVE---------- 116 ......----.----..---..-----...------------------.---------------- 117 ......RPHA.NRFL..PPD..EIEQS...LNGVHYQHHIQPITLWFD.D--------------- 118 ......RPHA.NRFL..PPD..EIEQS...LNGVHYQHHIQPITLWFD.D--------------- 119 ......WGPG.YRHD..AEF..VTDPP...SQFSFYRWSRADYESAIA.DAGFSHFEWQKPLLEA 120 qkepesPFVD.GEVV..GIN..FYANGevcGSSKIALHSREFYEQCFK.AAGFSQIEWIAPHF-- 121 ......VPSV.GRFY..SGNsyAYSYL...KESIRNLPCDTSLERVFH.KSGLHIIRKRKLLFGT 122 ......VPSV.GRFY..SGNsyAYSYL...KESIRDLPRDAALEAIFH.AAHLRPIRKRKLLFGT 123 ......----.----..---..INFYI...DPTHKKPVHPETLKFILE.YLGFRDVKIEFFEE-- 124 ......VFLG.GALR..TRE..KWDG-...---------------L--.---------------- 125 ......VFLG.GALR..TRE..KWDG-...---------------L--.---------------- 126 ......----.----..---..-----...------------------.---------------- 127 ......----.----..--S..EELKA...NYSKIEFKPEDFEMWLIE.TVGFESVE-------- 128 ......----.----..--S..EELKA...NYSKIEFKPEDFEMWLIE.TVGFESVE-------- 129 ......----.----..---..-----...------------------.---------------- 130 ......----.----..---..-----...------------------.---------------- 131 ......----.----..---..-----...------------------.---------------- 240 | 1 ------- 2 ------- 3 ------- 4 ------- 5 ------- 6 ------- 7 ------- 8 ------- 9 ------- 10 ------- 11 ------- 12 ------- 13 ------- 14 ------- 15 ------- 16 ------- 17 SVIELHK 18 ------- 19 ------- 20 QAGV--- 21 ------- 22 ------- 23 ------- 24 ------- 25 ------- 26 ------- 27 ------- 28 AAFGAVK 29 ------- 30 ------- 31 ------- 32 ------- 33 ------- 34 ------- 35 ------- 36 ------- 37 ------- 38 ------- 39 GSLVALK 40 GSMIAVK 41 GSMIAVK 42 TLLVARK 43 TLLVARK 44 ETFIAFK 45 ------- 46 ------- 47 ------- 48 ------- 49 ------- 50 ------- 51 ------- 52 SSMFIAK 53 STTMLVK 54 ------- 55 ------- 56 AAM---- 57 ------- 58 ------- 59 ------- 60 ------- 61 ------- 62 ------- 63 ------- 64 ------- 65 ------- 66 ------- 67 ------- 68 ------- 69 ------- 70 ------- 71 ------- 72 ------- 73 ------- 74 ------- 75 ------- 76 ------- 77 ------- 78 ------- 79 ------- 80 ------- 81 ------- 82 ------- 83 ------- 84 ------- 85 ------- 86 ------- 87 ------- 88 ------- 89 ------- 90 ------- 91 ------- 92 ------- 93 ------- 94 ------- 95 ------- 96 ------- 97 DAILARK 98 ------- 99 ------- 100 ------- 101 ------- 102 ------- 103 ------- 104 ------- 105 VRLIIA- 106 ------- 107 ------- 108 ------- 109 ------- 110 ------- 111 ------- 112 ------- 113 ------- 114 ------- 115 ------- 116 ------- 117 ------- 118 ------- 119 D------ 120 ------- 121 ATIWIL- 122 ATIWIL- 123 ------- 124 ------- 125 ------- 126 ------- 127 ------- 128 ------- 129 ------- 130 ------- 131 -------