a2m2html output for file tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1999.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- T0092 HI0319, H. influenzae
- gi|1175220|sp|P43985|YECO_HAEIN_1:241 HYPOTHETICAL PROTEIN HI0319 (Haemophilus influenzae)
- gi|1074350|pir||C64006 probable S-adenosylmethionine-dependent methyltransferase HI0319 - Haemophilus influenzae (strain Rd KW20) (Haemophilus influenzae)
- gi|1573289|gb|AAC21983.1| (U32717) conserved hypothetical protein [Haemophilus influenzae Rd] (Haemophilus influenzae Rd)
- gi|3025151|sp|P76290|YECO_ECOLI_3:242 HYPOTHETICAL 27.8 KD PROTEIN IN ASPS-BISZ INTERGENIC REGION (Escherichia coli)
- gi|7449892|pir||F64949 probable S-adenosylmethionine-dependent methyltransferase yecO - Escherichia coli (Escherichia coli)
- gi|1736516|dbj|BAA15680.1| (D90829) ORF_ID:o337#11; similar to [SwissProt Accession Number P43985] [Escherichia coli] (Escherichia coli)
- gi|1788177|gb|AAC74940.1| (AE000280) orf, hypothetical protein [Escherichia coli] (Escherichia coli)
- gi|6968057|emb|CAB75226.1|_1:235 (AL139075) hypothetical protein Cj0590 [Campylobacter jejuni] (Campylobacter jejuni)
- gi|7449893|pir||F71861_2:242 hypothetical protein jhp0993 - Helicobacter pylori (strain J99) (Helicobacter pylori)
- gi|4155577|gb|AAD06570.1| (AE001528) putative [Helicobacter pylori J99] (Helicobacter pylori J99)
- gi|7449894|pir||D64568_2:242 conserved hypothetical protein HP0388 - Helicobacter pylori (strain 26695) (Helicobacter pylori)
- gi|2313489|gb|AAD07453.1| (AE000555) conserved hypothetical protein [Helicobacter pylori 26695] (Helicobacter pylori 26695)
- gi|7292119|gb|AAF47531.1|_5:216 (AE003472) CG13929 gene product [alt 1] [Drosophila melanogaster] (Drosophila melanogaster)
- gi|7292120|gb|AAF47532.1| (AE003472) CG13929 gene product [alt 2] [Drosophila melanogaster] (Drosophila melanogaster)
- gi|1346175|sp|P49016|GRCB_LACLA_37:225 PROBABLE MENAQUINONE BIOSYNTHESIS METHYLTRANSFERASE (GERC2 PROTEIN HOMOLOG) (Lactococcus lactis subsp. lactis)
- gi|410740|gb|AAA03166.1| (L14679) putative [Lactococcus lactis] (Lactococcus lactis)
- gi|538899|pir||B48653_37:225 hypothetical protein 2 (pip 3' region) - Lactococcus lactis subsp. lactis (strain C2) (Lactococcus lactis subsp. lactis)
- gi|7470360|pir||S74478_16:256 hypothetical protein slr1115 - Synechocystis sp. (strain PCC 6803) (Synechocystis sp.)
- gi|1651702|dbj|BAA16630.1| (D90899) hypothetical protein [Synechocystis sp.] (Synechocystis sp.)
- gi|7674095|sp|O86169|MENH_BACST_28:228 2-HEPTAPRENYL-1,4-NAPHTHOQUINONE METHYLTRANSFERASE (MENAQUINONE BIOSYNTHESIS METHYLTRANSFERASE) (Bacillus stearothermophilus)
- gi|3452684|dbj|BAA32500.1| (D87054) 2-heptaprenyl-1,4-naphthoquinone methyltransferase [Bacillus stearothermophilus] (Bacillus stearothermophilus)
- gi|3075397|gb|AAC14529.1|_47:258 (AC004484) hypothetical protein [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|7443714|pir||T42375_45:224 probable 24-sterol C-methyltransferase (EC 2.1.1.41) - fission yeast (Schizosaccharomyces pombe) (fragment) (Schizosaccharomyces pombe)
- gi|1749470|dbj|BAA13793.1| (D89131) similar to Saccharomyces cerevisiae delta (24)-sterol C-methyltransferase, SWISS-PROT Accession number P25087 [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|6166151|sp|O14321|ERG6_SCHPO_99:278 PROBABLE DELTA(24)-STEROL C-METHYLTRANSFERASE (Schizosaccharomyces pombe)
- gi|7493435|pir||T39579 sterol methyltransferase - fission yeast (Schizosaccharomyces pombe) (Schizosaccharomyces pombe)
- gi|2467267|emb|CAB16897.1| (Z99759) putative delta-sterol c-methyltransferase [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|6015114|sp|O74198|ERG6_CANAL_97:273 DELTA(24)-STEROL C-METHYLTRANSFERASE (Candida albicans)
- gi|3323500|gb|AAC26626.1| (AF031941) sterol transmethylase [Candida albicans] (Candida albicans)
- gi|1632838|emb|CAA64854.1|_16:217 (X95596) methyltransferase [Streptomyces griseus] (Streptomyces griseus)
- gi|6324814|ref|NP_014883.1|_119:324 Yor240wp (Saccharomyces cerevisiae)
- gi|2132923|pir||S67133 probable membrane protein YOR240w - yeast (Saccharomyces cerevisiae) (Saccharomyces cerevisiae)
- gi|1420548|emb|CAA99461.1| (Z75147) ORF YOR240w [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|6692724|gb|AAF24830.1|AC012679_1_56:230 (AC012679) putative S-adenosyl-methionine-sterol-C-methyltransferase, 5' partial [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|516113|gb|AAA87622.1|_6:184 (L34880) aklanonic acid methyltransferase [Streptomyces sp.] (Streptomyces sp.)
- gi|530212|gb|AAB16936.1|_30:210 (L35154) aklanonic acid methyltransferase [Streptomyces sp.] (Streptomyces sp.)
- gi|7481052|pir||T37021_15:216 probable methyltransferase - Streptomyces coelicolor (Streptomyces coelicolor)
- gi|5777665|emb|CAB53414.1| (AL109989) putative methyltransferase [Streptomyces coelicolor A3(2)] (Streptomyces coelicolor A3(2))
- gi|532249|gb|AAA65210.1|_31:212 (L35560) ORF5 [Streptomyces peucetius] (Streptomyces peucetius)
- gi|1093567|prf||2104259J ORF 5 [Streptomyces peucetius] (Streptomyces peucetius)
- gi|7800670|gb|AAF70111.1|AF257324_12_32:213 (AF257324) AknG [Streptomyces galilaeus] (Streptomyces galilaeus)
- gi|7023954|dbj|BAA92136.1|_116:278 (AK002212) unnamed protein product [Homo sapiens] (Homo sapiens)
- gi|3776564|gb|AAC64881.1|_55:298 (AC005388) Similar to hypothetical protein T1D16.16 gi|3075397 from A. thaliana BAC gb|AC004484. [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|2495672|sp|Q57060|Y095_HAEIN_1:189 HYPOTHETICAL PROTEIN HI0095 (Haemophilus influenzae)
- gi|1075323|pir||B64048 hypothetical protein HI0095 - Haemophilus influenzae (strain Rd KW20) (Haemophilus influenzae)
- gi|1573047|gb|AAC21772.1| (U32695) conserved hypothetical protein [Haemophilus influenzae Rd] (Haemophilus influenzae Rd)
- gi|729153|sp|Q06528|CM4T_STRPE_142:321 CARMINOMYCIN 4-O-METHYLTRANSFERASE (COMT) (Streptomyces peucetius)
- gi|538993|pir||A47128 carminomycin 4-O-methyltransferase (EC 2.1.1.-) - Streptomyces peucetius (Streptomyces peucetius)
- gi|295169|gb|AAA26712.1| (L13453) carminomycin 4-O-methyltransferase [Streptomyces peucetius] (Streptomyces peucetius)
- gi|703439|gb|AAA99001.1| (L40425) carminomycin o-methyltransferase [Streptomyces peucetius] (Streptomyces peucetius)
- gi|7490350|pir||T40404_15:219 conserved hypothetical protein SPBC3H7.11 - fission yeast (Schizosaccharomyces pombe) (Schizosaccharomyces pombe)
- gi|3417419|emb|CAA20307.1| (AL031261) conserved hypothetical protein [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|6841182|gb|AAF28944.1|AF161384_1_179:341 (AF161384) HSPC266 [Homo sapiens] (Homo sapiens)
- gi|530214|gb|AAB16938.1|_142:321 (L35154) carminomycin 4-O-methyltransferase [Streptomyces sp.] (Streptomyces sp.)
- gi|6967798|emb|CAB72791.1|_37:233 (AL139074) ubiquinone\menaquinone biosynthesis methlytransferase [Campylobacter jejuni] (Campylobacter jejuni)
- gi|7478388|pir||B70614_47:224 probable mmaA1 protein - Mycobacterium tuberculosis (strain H37RV) (Mycobacterium tuberculosis)
- gi|1825532|gb|AAC44873.1| (U77466) CmaD [Mycobacterium bovis BCG] (Mycobacterium bovis BCG)
- gi|3261723|emb|CAB07126.1| (Z92772) mmaA1 [Mycobacterium tuberculosis] (Mycobacterium tuberculosis)
- gi|7106072|emb|CAB76043.1|_69:265 (AL157918) putative methyltransferase [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|7328463|dbj|BAA92862.1|_11:218 (AB040403) TRP-1 [Burkholderia glumae] (Burkholderia glumae)
- gi|4731342|gb|AAD28459.1|AF127374_14_30:221 (AF127374) MitM [Streptomyces lavendulae] (Streptomyces lavendulae)
- gi|7407189|gb|AAF61950.1|AF237633_1_249:428 (AF237633) phosphoethanolamine N-methyltransferase [Spinacia oleracea] (Spinacia oleracea)
- gi|2916809|emb|CAA12014.1|_31:212 (AJ224512) SnoaC [Streptomyces nogalater] (Streptomyces nogalater)
- gi|7509433|pir||T26512_115:346 hypothetical protein Y17G7B.18b - Caenorhabditis elegans (Caenorhabditis elegans)
- gi|3947614|emb|CAA19466.1| (AL023828) cDNA EST yk491f8.5 comes from this gene [Caenorhabditis elegans] (Caenorhabditis elegans)
- gi|7672273|emb|CAB89463.1|_189:360 (AL354048) putative fatty acid synthase [Streptomyces coelicolor A3(2)] (Streptomyces coelicolor A3(2))
- gi|7509432|pir||T26511_112:343 hypothetical protein Y17G7B.18a - Caenorhabditis elegans (Caenorhabditis elegans)
- gi|3947613|emb|CAA19465.1| (AL023828) cDNA EST EMBL:M89008 comes from this gene; cDNA EST yk282d3.5 comes from this gene [Caenorhabditis elegans] (Caenorhabditis elegans)
- gi|7474059|pir||F75277_46:222 ubiquinone/menaquinone biosynthesis methyltransferase - Deinococcus radiodurans (strain R1) (Deinococcus radiodurans)
- gi|6460221|gb|AAF11949.1|AE002071_3 (AE002071) ubiquinone/menaquinone biosynthesis methyltransferase [Deinococcus radiodurans] (Deinococcus radiodurans)
- gi|1575546|gb|AAC44616.1|_47:224 (U66108) methoxy mycolic acid synthase 1 [Mycobacterium tuberculosis] (Mycobacterium tuberculosis)
- gi|730914|sp|P39896|TCMO_STRGA_161:322 TETRACENOMYCIN POLYKETIDE SYNTHESIS 8-O-METHYL TRANSFERASE TCMO (Streptomyces glaucescens)
- gi|282561|pir||C42276 O-methyltransferase - Streptomyces glaucescens (Streptomyces glaucescens)
- gi|153500|gb|AAA67519.1| (M80674) O-methyltransferase [Streptomyces glaucescens] (Streptomyces glaucescens)
- gi|1723586|sp|P45558|PRMA_CLOAB_129:297 PROBABLE METHYLTRANSFERASE (Clostridium acetobutylicum)
- gi|1246430|emb|CAA48793.1| (X69050) orfB [Clostridium acetobutylicum] (Clostridium acetobutylicum)
- gi|7445290|pir||D71516_16:227 probable ubiquinone methyltransferase - Chlamydia trachomatis (serotype D, strain UW3/Cx) (Chlamydia trachomatis)
- gi|3328858|gb|AAC68025.1| (AE001316) Ubiquinone Methyltransferase [Chlamydia trachomatis] (Chlamydia trachomatis)
- gi|541428|pir||S41759_129:297 ribosomal protein L11 methyltransferase (EC 2.1.1.-) - Clostridium acetobutylicum (Clostridium acetobutylicum)
- gi|7190742|gb|AAF39525.1|_27:237 (AE002339) ubiquinone/menaquinone biosynthesis methyltransferase [Chlamydia muridarum] (Chlamydia muridarum)
- gi|7496359|pir||T33131_11:222 hypothetical protein C23H5.1 - Caenorhabditis elegans (Caenorhabditis elegans)
- gi|3158481|gb|AAC17532.1| (AF067609) contains similarity to methyltransferases [Caenorhabditis elegans] (Caenorhabditis elegans)
- gi|7462981|pir||E72392_6:199 ubiquinone/menaquinone biosynthesis-related protein - Thermotoga maritima (strain MSB8) (Thermotoga maritima)
- gi|4980819|gb|AAD35406.1|AE001713_10 (AE001713) ubiquinone/menaquinone biosynthesis-related protein [Thermotoga maritima] (Thermotoga maritima)
- gi|2506982|sp|P12999|BIOC_ECOLI_27:193 BIOTIN SYNTHESIS PROTEIN BIOC (Escherichia coli)
- gi|7429011|pir||BVECBC biotin biosynthesis protein bioC - Escherichia coli (Escherichia coli)
- gi|1786994|gb|AAC73864.1| (AE000180) biotin biosynthesis; reaction prior to pimeloyl CoA [Escherichia coli] (Escherichia coli)
- gi|145427|gb|AAA23517.1|_27:193 (J04423) bioC [Escherichia coli] (Escherichia coli)
- gi|7471558|pir||E75511_1:180 conserved hypothetical protein - Deinococcus radiodurans (strain R1) (Deinococcus radiodurans)
- gi|6458193|gb|AAF10083.1|AE001909_5 (AE001909) conserved hypothetical protein [Deinococcus radiodurans] (Deinococcus radiodurans)
- gi|7429749|pir||C64705_47:244 gerC2 protein - Helicobacter pylori (strain 26695) (Helicobacter pylori)
- gi|2314655|gb|AAD08518.1| (AE000647) gerC2 protein (gerC2) [Helicobacter pylori 26695] (Helicobacter pylori 26695)
- gi|7473566|pir||C75569_31:199 probable methyltransferase - Deinococcus radiodurans (strain R1) (Deinococcus radiodurans)
- gi|6457685|gb|AAF09618.1|AE001866_5 (AE001866) methyltransferase, putative [Deinococcus radiodurans] (Deinococcus radiodurans)
- gi|141450|sp|P20187|YT37_STRFR_101:279 HYPOTHETICAL 37.1 KD PROTEIN IN TRANSPOSON TN4556 (Streptomyces fradiae)
- gi|80760|pir||JQ0429 hypothetical 37.1K protein - Streptomyces fradiae transposon Tn4556 (Streptomyces fradiae)
- gi|1196914|gb|AAA88564.1| (M29297) unknown protein [Streptomyces fradiae] (Streptomyces fradiae)
- gi|1170276|sp|P46597|HIOM_HUMAN_184:345 HYDROXYINDOLE O-METHYLTRANSFERASE (HIOMT) (ACETYLSEROTONIN O-METHYLTRANSFERASE) (ASMT) (Homo sapiens)
- gi|607854|gb|AAA75291.1| (U11098) hydroxyindole-O-methyltransferase [Homo sapiens] (Homo sapiens)
- gi|4104516|gb|AAD02056.1|_63:230 (AF036764) unknown [Clostridium acetobutylicum] (Clostridium acetobutylicum)
- gi|7484088|pir||T08338_198:354 hypothetical protein H1434 - Halobacterium sp. (strain NRC-1) plasmid pNRC100 (Halobacterium sp.)
- gi|2822399|gb|AAC82905.1| (AF016485) ORF H1434 [Halobacterium sp. NRC-1] (Halobacterium sp. NRC-1)
- gi|6598836|gb|AAF18691.1|AC010795_6_178:381 (AC010795) putative o-methyltransferase [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|1890588|emb|CAB01936.1|_58:240 (Z79692) ExpE3 [Sinorhizobium meliloti] (Sinorhizobium meliloti)
- gi|1575549|gb|AAC44619.1|_62:240 (U66108) methoxy mycolic acid synthase 4 [Mycobacterium tuberculosis] (Mycobacterium tuberculosis)
- gi|2281316|gb|AAC45501.1|_11:188 (U80599) OrfA; similar to Synechocytis sp. methyltransferase encoded by GenBank Accession Number D64003 [Lactococcus lactis subsp. cremoris] (Lactococcus lactis subsp. cremoris)
- gi|7518112|pir||D75063_134:303 hypothetical protein PAB1377 - Pyrococcus abyssi (strain Orsay) (Pyrococcus abyssi)
- gi|5458914|emb|CAB50401.1| (AJ248287) hypothetical protein [Pyrococcus abyssi] (Pyrococcus abyssi)
- gi|7518704|pir||E71168_137:306 hypothetical protein PH0545 - Pyrococcus horikoshii (Pyrococcus horikoshii)
- gi|3256951|dbj|BAA29634.1| (AP000002) 323aa long hypothetical protein [Pyrococcus horikoshii] (Pyrococcus horikoshii)
- gi|7521702|pir||C75210_6:141 sterol biosynthesis methyltransferase related PAB2213 - Pyrococcus abyssi (strain Orsay) (Pyrococcus abyssi)
- gi|5457639|emb|CAB49130.1| (AJ248283) sterol biosynthesis methyltransferase related [Pyrococcus abyssi] (Pyrococcus abyssi)
- gi|1825535|gb|AAC44876.1|_59:237 (U77466) CmaA [Mycobacterium bovis BCG] (Mycobacterium bovis BCG)
- gi|5902658|gb|AAD55585.1|_154:326 (AF077869) O-methyltransferase [Streptomyces argillaceus] (Streptomyces argillaceus)
- gi|7479391|pir||T34740_28:205 hypothetical protein SC1E6.19c SC1E6.19c - Streptomyces coelicolor (Streptomyces coelicolor)
- gi|3861442|emb|CAA22047.1| (AL033505) hypothetical protein SC1E6.19c [Streptomyces coelicolor A3(2)] (Streptomyces coelicolor A3(2))
- gi|7416784|dbj|BAA94033.1|_197:383 (AB034704) hydroxyneurosporene methyltransferase [Rubrivivax gelatinosus] (Rubrivivax gelatinosus)
- gi|6968616|emb|CAB73437.1|_139:314 (AL139077) putative cyclopropane-fatty-acyl-phospholipid synthase [Campylobacter jejuni] (Campylobacter jejuni)
- gi|6136578|sp|Q55423|Y829_SYNY3_31:191 PUTATIVE METHYLTRANSFERASE SLL0829 (Synechocystis PCC6803)
- gi|7470741|pir||S75787 methyltransferase - Synechocystis sp. (strain PCC 6803) (Synechocystis sp.)
- gi|1001276|dbj|BAA10522.1| (D64003) methyltransferase [Synechocystis sp.] (Synechocystis sp.)
- gi|7480087|pir||T36753_20:176 hypothetical protein SCI11.20c - Streptomyces coelicolor (Streptomyces coelicolor)
- gi|5531441|emb|CAB50946.1| (AL096849) hypothetical protein [Streptomyces coelicolor A3(2)] (Streptomyces coelicolor A3(2))
- gi|7481048|pir||T34921_173:340 probable methyltransferase - Streptomyces coelicolor (Streptomyces coelicolor)
- gi|2808756|emb|CAA16186.1| (AL021409) putative methyltransferase [Streptomyces coelicolor A3(2)] (Streptomyces coelicolor A3(2))
- gi|7688721|gb|AAF67508.1|AF170880_15_8:175 (AF170880) NovO [Streptomyces spheroides] (Streptomyces spheroides)
- gi|7483336|pir||F69255_255:427 hypothetical protein AF0046 - Archaeoglobus fulgidus (Archaeoglobus fulgidus)
- gi|2650608|gb|AAB91186.1| (AE001103) A. fulgidus predicted coding region AF0046 [Archaeoglobus fulgidus] (Archaeoglobus fulgidus)
- gi|7517797|pir||A75217_4:200 hypothetical protein PAB0179 - Pyrococcus abyssi (strain Orsay) (Pyrococcus abyssi)
- gi|5457693|emb|CAB49184.1| (AJ248283) hypothetical protein [Pyrococcus abyssi] (Pyrococcus abyssi)
- gi|1771204|emb|CAA68045.1|_12:184 (X99710) methyltransferase [Lactococcus lactis] (Lactococcus lactis)
- gi|7407189|gb|AAF61950.1|AF237633_1_16:165 (AF237633) phosphoethanolamine N-methyltransferase [Spinacia oleracea] (Spinacia oleracea)
- gi|1076062|pir||JC4099_89:270 hypothetical 32.1k protein - Streptomyces aureofaciens (Streptomyces aureofaciens)
- gi|1100767|dbj|BAA07388.1| (D38214) possible enzyme methylating tetracycline [Streptomyces aureofaciens] (Streptomyces aureofaciens)
- gi|7518537|pir||C71246_6:142 hypothetical protein PH0226 - Pyrococcus horikoshii (Pyrococcus horikoshii)
- gi|3256615|dbj|BAA29298.1| (AP000001) 227aa long hypothetical protein [Pyrococcus horikoshii] (Pyrococcus horikoshii)
- gi|7519075|pir||A71001_10:142 hypothetical protein PH1305 - Pyrococcus horikoshii (Pyrococcus horikoshii)
- gi|3257726|dbj|BAA30409.1| (AP000006) 252aa long hypothetical protein [Pyrococcus horikoshii] (Pyrococcus horikoshii)
- gi|1175329|sp|P44074|Y912_HAEIN_8:150 HYPOTHETICAL PROTEIN HI0912 (Haemophilus influenzae)
- gi|1074559|pir||B64016 hypothetical protein HI0912 - Haemophilus influenzae (strain Rd KW20) (Haemophilus influenzae)
- gi|1573933|gb|AAC22579.1| (U32773) H. influenzae predicted coding region HI0912 [Haemophilus influenzae Rd] (Haemophilus influenzae Rd)
- gi|7470235|pir||S74397_19:177 hypothetical protein slr0482 - Synechocystis sp. (strain PCC 6803) (Synechocystis sp.)
- gi|1001172|dbj|BAA10315.1| (D64001) hypothetical protein [Synechocystis sp.] (Synechocystis sp.)
- gi|7511552|pir||T18571_301:458 probable cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) - Caenorhabditis elegans (Caenorhabditis elegans)
- gi|3947448|emb|CAA22134.1| (AL033535) cDNA EST yk301f1.5 comes from this gene; cDNA EST yk475f6.3 comes from this gene; cDNA EST yk301f1.3 comes from this gene; cDNA EST yk475f6.5 comes from this gene; cDNA EST yk499g5.5 comes from this gene; cDNA EST yk648d9.3 comes from this g> (Caenorhabditis elegans)
- gi|3947543|emb|CAA88952.1| (Z49127) cDNA EST yk301f1.5 comes from this gene; cDNA EST yk475f6.3 comes from this gene; cDNA EST yk301f1.3 comes from this gene; cDNA EST yk475f6.5 comes from this gene; cDNA EST yk499g5.5 comes from this gene; cDNA EST yk648d9.3 comes from this gen> (Caenorhabditis elegans)
- gi|543890|sp|P36571|BIOC_SERMA_30:159 BIOTIN SYNTHESIS PROTEIN BIOC (Serratia marcescens)
- gi|402534|dbj|BAA04287.1| (D17468) the product of bioC [Serratia marcescens] (Serratia marcescens)
- gi|2829568|sp|P71779|YE98_MYCTU_2:151 HYPOTHETICAL 23.1 KDA PROTEIN RV1498C (Mycobacterium tuberculosis)
- gi|7476789|pir||E70712 hypothetical protein Rv1498c - Mycobacterium tuberculosis (strain H37RV) (Mycobacterium tuberculosis)
- gi|1524245|emb|CAB02048.1| (Z79701) hypothetical protein Rv1498c [Mycobacterium tuberculosis] (Mycobacterium tuberculosis)
- gi|7469840|pir||S76978_57:219 hypothetical protein - Synechocystis sp. (strain PCC 6803) (Synechocystis sp.)
- gi|1001790|dbj|BAA10670.1| (D64005) hypothetical protein [Synechocystis sp.] (Synechocystis sp.)
- gi|7470129|pir||S77194_37:159 hypothetical protein sll1693 - Synechocystis sp. (strain PCC 6803) (Synechocystis sp.)
- gi|1652833|dbj|BAA17752.1| (D90908) hypothetical protein [Synechocystis sp.] (Synechocystis sp.)
- gi|6094425|sp|P76145|TAM_ECOLI_16:139 TRANS-ACONITATE METHYLTRANSFERASE (Escherichia coli)
- gi|7465793|pir||B64906 biotin biosynthesis protein homolog b1519 - Escherichia coli (Escherichia coli)
- gi|1787798|gb|AAC74592.1| (AE000249) putative enzyme [Escherichia coli] (Escherichia coli)
- gi|7490910|pir||T38024_23:164 hypothetical protein SPAC1B3.06c - fission yeast (Schizosaccharomyces pombe) (Schizosaccharomyces pombe)
- gi|2330740|emb|CAB11235.1| (Z98598) methyltransferase-UbiE family [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|7491966|pir||T41554_22:187 hypothetical protein SPCC70.08c - fission yeast (Schizosaccharomyces pombe) (Schizosaccharomyces pombe)
- gi|3192028|emb|CAA19358.1| (AL023794) probable methyltransferase [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|7445263|pir||C75155_13:143 methlytransferase PAB0269 - Pyrococcus abyssi (strain Orsay) (Pyrococcus abyssi)
- gi|5457832|emb|CAB49322.1| (AJ248284) METHLYTRANSFERASE [Pyrococcus abyssi] (Pyrococcus abyssi)
- gi|7298756|gb|AAF53967.1|_38:173 (AE003669) CG9249 gene product [Drosophila melanogaster] (Drosophila melanogaster)
- gi|6321023|ref|NP_011102.1|_25:193 Yer175cp (Saccharomyces cerevisiae)
- gi|418431|sp|P32643|YE05_YEAST HYPOTHETICAL 34.8 KD PROTEIN IN RAD24-BMH1 INTERGENIC REGION (Saccharomyces cerevisiae)
- gi|320743|pir||S30861 hypothetical protein YER175c - yeast (Saccharomyces cerevisiae) (Saccharomyces cerevisiae)
- gi|603416|gb|AAB64702.1| (U18922) Yer175cp [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|2073517|emb|CAA72463.1|_64:177 (Y11779) hypothetical protein [Rickettsia prowazekii] (Rickettsia prowazekii)
- gi|6226396|sp|O05979|Y789_RICPR_64:177 HYPOTHETICAL PROTEIN RP789 (Rickettsia prowazekii)
- gi|7467855|pir||G71639 hypothetical protein RP789 - Rickettsia prowazekii (Rickettsia prowazekii)
- gi|3861316|emb|CAA15215.1| (AJ235273) unknown [Rickettsia prowazekii] (Rickettsia prowazekii)
- gi|7495376|pir||T33771_54:216 hypothetical protein C04F5.8 - Caenorhabditis elegans (Caenorhabditis elegans)
- gi|3806128|gb|AAC69201.1| (AF101305) C04F5.8 gene product [Caenorhabditis elegans] (Caenorhabditis elegans)
- gi|6491814|emb|CAB61860.1|_72:225 (AL133252) putative methyltransferase [Streptomyces coelicolor A3(2)] (Streptomyces coelicolor A3(2))
- gi|7467445|pir||T17439_1162:1298 peptide synthetase homolog - Yersinia pestis (Yersinia pestis)
- gi|3818604|gb|AAC69587.1| (AF091251) Ybt peptide synthetase HMWP2 [Yersinia pestis] (Yersinia pestis)
- gi|4106635|emb|CAA21390.1| (AL031866) ORF67, len=2041 aa, irp2, function=synthesis of siderophore yersiniabactin, product=HMWP2 protein 98.6% identity in 2035 aa overlap to HMP2_YEREN. also highly similar to ANGR_VIBAN, (1048 aa), 44.4% identity in 917 aa overlap, Fasta scores: > (Yersinia pestis)
- gi|3758823|emb|CAA09857.1|_37:184 (AJ011907) hypothetical protein [Klebsiella pneumoniae] (Klebsiella pneumoniae)
- gi|408802|gb|AAA27636.1|_1156:1292 (L18881) HMWP2; homologous to angR [Yersinia enterocolitica] (Yersinia enterocolitica)
- gi|1346305|sp|P48633|HMP2_YEREN_1156:1292 HIGH-MOLECULAR-WEIGHT PROTEIN 2 (HMWP2) (Yersinia enterocolitica)
- gi|538818|pir||A48654 high-molecular-weight protein 2 - Yersinia enterocolitica (Yersinia enterocolitica)
- gi|7416806|dbj|BAA94055.1|_44:153 (AB034704) Mg protoporphyrin IX monomethyl ester oxidative cyclase subunit [Rubrivivax gelatinosus] (Rubrivivax gelatinosus)
- gi|7471497|pir||D75520_17:131 conserved hypothetical protein - Deinococcus radiodurans (strain R1) (Deinococcus radiodurans)
- gi|6458104|gb|AAF10001.1|AE001902_1 (AE001902) conserved hypothetical protein [Deinococcus radiodurans] (Deinococcus radiodurans)
- gi|6434718|emb|CAB61165.1|_43:197 (AL132973) putative methyltransferase. [Streptomyces coelicolor A3(2)] (Streptomyces coelicolor A3(2))
- gi|7496331|pir||T33109_13:128 hypothetical protein C18H7.9 - Caenorhabditis elegans (Caenorhabditis elegans)
- gi|3165527|gb|AAC17646.1| (AF067607) contains similarity to methyltransferases [Caenorhabditis elegans] (Caenorhabditis elegans)
- gi|3724043|emb|CAA04312.1|_202:363 (AJ000758) CbiET protein [Bacillus megaterium] (Bacillus megaterium)
- gi|7303243|gb|AAF58305.1|_66:222 (AE003816) CG8067 gene product [Drosophila melanogaster] (Drosophila melanogaster)
- gi|7514524|pir||D70359_31:166 conserved hypothetical protein aq_674 - Aquifex aeolicus (Aquifex aeolicus)
- gi|2983274|gb|AAC06868.1| (AE000701) hypothetical protein [Aquifex aeolicus] (Aquifex aeolicus)
- gi|6319738|ref|NP_009820.1|_42:205 Ybr261cp (Saccharomyces cerevisiae)
- gi|586379|sp|P38340|YB9H_YEAST HYPOTHETICAL 26.1 KD PROTEIN IN POP4-SHM1 INTERGENIC REGION (Saccharomyces cerevisiae)
- gi|419870|pir||S32963 hypothetical protein YBR261c - yeast (Saccharomyces cerevisiae) (Saccharomyces cerevisiae)
- gi|296560|emb|CAA49926.1| (X70529) ORF YBR1729 [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|536689|emb|CAA85224.1| (Z36130) ORF YBR261c [Saccharomyces cerevisiae] (Saccharomyces cerevisiae)
- gi|7299975|gb|AAF55147.1|_235:348 (AE003708) CG6563 gene product [Drosophila melanogaster] (Drosophila melanogaster)
- gi|2128868|pir||C64481_13:122 conserved hypothetical protein MJ1452 - Methanococcus jannaschii (Methanococcus jannaschii)
- gi|1500335|gb|AAB99463.1| (U67586) conserved hypothetical protein [Methanococcus jannaschii] (Methanococcus jannaschii)
- gi|7486450|pir||T05192_50:168 hypothetical protein F4I10.50 - Arabidopsis thaliana (Arabidopsis thaliana)
- gi|4455326|emb|CAB36786.1| (AL035525) putative protein [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|7270259|emb|CAB80029.1| (AL161582) putative protein [Arabidopsis thaliana] (Arabidopsis thaliana)
- gi|7380059|emb|CAB84640.1|_140:291 (AL162755) hypothetical protein NMA1400 [Neisseria meningitidis] (Neisseria meningitidis)
- gi|7226471|gb|AAF41613.1|_115:245 (AE002471) conserved hypothetical protein [Neisseria meningitidis] (Neisseria meningitidis)
- gi|3183316|sp|O13748|YDRE_SCHPO_45:162 HYPOTHETICAL 24.4 KD PROTEIN C16E8.14C IN CHROMOSOME I (Schizosaccharomyces pombe)
- gi|7490834|pir||T37794 hypothetical protein SPAC16E8.14c - fission yeast (Schizosaccharomyces pombe) (Schizosaccharomyces pombe)
- gi|2330702|emb|CAB11042.1| (Z98529) hypothetical protein [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|7516544|pir||H72630_34:150 hypothetical protein APE1503 - Aeropyrum pernix (strain K1) (Aeropyrum pernix)
- gi|5105188|dbj|BAA80502.1| (AP000061) 181aa long hypothetical protein [Aeropyrum pernix] (Aeropyrum pernix)
- gi|6015918|emb|CAB57745.1|_17:113 (Y18930) hypothetical protein [Sulfolobus solfataricus] (Sulfolobus solfataricus)
- gi|7451049|pir||F69198_18:167 conserved hypothetical protein MTH738 - Methanobacterium thermoautotrophicum (strain Delta H) (Methanobacterium thermoautotrophicum)
- gi|2621827|gb|AAB85242.1| (AE000853) conserved protein [Methanobacterium thermoautotrophicum] (Methanobacterium thermoautotrophicum)
- gi|7469807|pir||S76919_21:132 hypothetical protein - Synechocystis sp. (strain PCC 6803) (Synechocystis sp.)
- gi|1653921|dbj|BAA18831.1| (D90917) hypothetical protein [Synechocystis sp.] (Synechocystis sp.)
- gi|7491567|pir||T40101_33:198 hypothetical protein SPBC2A9.10 - fission yeast (Schizosaccharomyces pombe) (Schizosaccharomyces pombe)
- gi|4539263|emb|CAB39852.1| (AL049495) hypothetical protein [Schizosaccharomyces pombe] (Schizosaccharomyces pombe)
- gi|2121206|pir||I76774_47:152 hypothetical protein 708 - Escherichia coli (Escherichia coli)
- gi|598469|dbj|BAA07749.1| (D43637) unknown [Escherichia coli] (Escherichia coli)
- gi|3088592|gb|AAC14722.1|_48:142 (AF059340) unknown [Synechococcus PCC7002] (Synechococcus PCC7002)
- gi|7291819|gb|AAF47239.1|_119:250 (AE003464) CG3570 gene product [Drosophila melanogaster] (Drosophila melanogaster)
- gi|2495889|sp|Q57732|Y284_METJA_9:108 HYPOTHETICAL PROTEIN MJ0284 (Methanococcus jannaschii)
- gi|2128214|pir||E64335 conserved hypothetical protein MJ0284 - Methanococcus jannaschii (Methanococcus jannaschii)
- gi|1499066|gb|AAB98272.1| (U67483) conserved hypothetical protein [Methanococcus jannaschii] (Methanococcus jannaschii)
- gi|1169553|sp|P45438|ERMK_BACLI_27:114 RRNA ADENINE N-6-METHYLTRANSFERASE (MACROLIDE-LINCOSAMIDE-STREPTOGRAMIN B RESISTANCE PROTEIN) (ERYTHROMYCIN RESISTANCE PROTEIN) (Bacillus licheniformis)
- gi|80107|pir||B42473 rRNA methylase ermK - Bacillus licheniformis (Bacillus licheniformis)
- gi|143195|gb|AAA22595.1| (M77505) erythromycin-inducible 23S ribosomal RNA methylase [Bacillus licheniformis] (Bacillus licheniformis)
- gi|477038|pir||A47697_27:114 probable methyltransferase (EC 2.1.1.-) - Bacillus anthracis (Bacillus anthracis)
- gi|1169552|sp|Q03986|ERMD_BACLI_27:114 RRNA ADENINE N-6-METHYLTRANSFERASE (MACROLIDE-LINCOSAMIDE-STREPTOGRAMIN B RESISTANCE PROTEIN) (ERYTHROMYCIN RESISTANCE PROTEIN) (Bacillus licheniformis)
- gi|2126802|pir||I39885 macrolide-lincosamide-streptogramin B resistance methylase - Bacillus licheniformis (Bacillus licheniformis)
- gi|143201|gb|AAA22599.1| (M29832) macrolide-lincosamide-streptogramin B resistance methylase [Bacillus licheniformis] (Bacillus licheniformis)
- gi|730032|sp|Q04720|ERMJ_BACAN_27:114 RRNA ADENINE N-6-METHYLTRANSFERASE (MACROLIDE-LINCOSAMIDE-STREPTOGRAMIN B RESISTANCE PROTEIN) (ERYTHROMYCIN RESISTANCE PROTEIN) (Bacillus anthracis)
- gi|143198|gb|AAA22597.1| (L08389) rRNA methyltransferase [Bacillus anthracis] (Bacillus anthracis)
- gi|2126366|pir||I40649_65:229 hypothetical protein 265 - Coxiella burnetii (Coxiella burnetii)
- gi|511454|gb|AAA56914.1| (U10529) unknown [Coxiella burnetii] (Coxiella burnetii)
- gi|7433474|pir||F69472_15:96 dimethyladenosine transferase (ksgA) homolog - Archaeoglobus fulgidus (Archaeoglobus fulgidus)
- gi|2648762|gb|AAB89464.1| (AE000979) dimethyladenosine transferase (ksgA) [Archaeoglobus fulgidus] (Archaeoglobus fulgidus)

              10           20        30        40        50            
              |            |         |         |         |            
   1 MVKDTLFSTPIAKLGDF...IFDENVAEVFPDMIQRSVPGYSNIITAIGMLAE.RFVTAD.SN..
   2 MVKDTLFSTPIAKLGDF...IFDENVAEVFPDMIQRSVPGYSNIITAIGMLAE.RFVTAD.SN..
   3 -HRDTLFSAPIARLGDW...TFDERVAEVFPDMIQRSVPGYSNIISMIGMLAE.RFVQPG.TQ..
   4 MMKDELFKQSPKK--QF...EFDKSVASVFDDMINRSVPFYRENLELCGNLLA.KILPTN.AS..
   5 --KDTLFNESLNK--RF...CFDEKVAHVFDDMLERSIPYYHEMLNLGAYFIA.QNLKEN.VYhk
   6 --KDTLFNESLNK--RF...CFDEKVAHVFDDMLERSIPYYHEMLNLGAYFIA.QNLKEN.IYpk
   7 --QKERFQTDAPKFWDS...FYGIHDNRFFKD----RHWLFTEFPELAPLAAD.SAVLQP.RS..
   8 -----------------...--------------------QHDLWRAKTMKRM.GDLT-G.LS..
   9 -----------------...--------------------QHDLWRAKTMKRM.GDLT-G.LS..
  10 -MTTPLEKKSTIEDIRS...RFDKDVARFSSLETGQATTIDAPLAMSLITEAA.ISCTKNiRH..
  11 -----------------...------------------SFRRHLKWRKDVMRR.MNVQKG.KK..
  12 -TNTDKYERDAKKYWDI...FYKHHGDRFFKD----------RHYLDKEWNSY.FSVSGK.SV..
  13 FYKGEAFAQSIARHEHY...-----------------------------LAYR.MGIKPG.SR..
  14 FYKGEAFAQSIARHEHY...-----------------------------LAYR.MGIKPG.SR..
  15 YYKGEAFRQATARHEHF...-----------------------------LAHK.MNLNEN.MK..
  16 -----------------...-----GSTAYDRLVSASPGYHAHLRRSARRLGL.PEEGRG.LR..
  17 EFDKKLYNENPARYWDI...FYKNNKENFFKD------RKWLQIEFPILYAST.RKDAEP.VT..
  18 -----------------...-------LRYERVFGEGFVSTGGLETTKEFVDM.LDLKPG.QK..
  19 -----------------...-------------------------MGRRLVDI.SEPVTG.ER..
  20 -----------------...-----------------------TPMGRRLVDI.SEPVTG.ER..
  21 -----------------...----HASHTYDGLTALNPGYRTGLLRSARRLAL.PADGAG.LH..
  22 -----------------...------------------------PMGRPLVEI.SEPVTG.ER..
  23 -----------------...-------------------------MGRRLVER.AAPAAG.AR..
  24 -----------------...---------------------------------.-----T.YR..
  25 -HSRHSSGKFFKVLHTH...HYSISCNQLLSFTIEEKFELVERRYLLKEFPEL.VSCGEN.SK..
  26 MAKDEVGHNFLARLGKT...RLRPGGKKATDW-----------------LIAN.GGFSQD.KK..
  27 FYEDLAGRPDLRASFDS...LLACDQDVAFDA-----------------PAAA.YDWTNV.RH..
  28 ------YKKESKKSWDK...FYKRNETRFFKD----RHWLDREFDCYFGLPDK.L----P.LT..
  29 -----------------...---------------------------------.-----T.YR..
  30 FYEDLAGRPDLRASFDS...LLACDQDVAFDA-----------------PAAA.HDWTNV.RH..
  31 -----------------...--------------------------ACQRVMS.LYLKKD.LK..
  32 -----------------...---------------------AQLAKVDLALDK.LNLEPG.MT..
  33 VTEKDAYMTHPERYWDQ...FYGKNEGKFFMN----RRWIAQEFPELLDLLKE.--DAGE.KS..
  34 -----------------...----------GGLFEDFTQSAAQAIEVRTIFHM.IGDVSG.KS..
  35 --------------GAA...SLGENLHFGYWDSPDSQVPLAEATDRLTDMMAErLRIGAG.SR..
  36 -----------------...-YKFNSILRYERVFGPGYVSTGGLETTKEFVSK.LDLKPG.QK..
  37 -----------------...------------------------PMGLRLVDH.ADPRPG.QR..
  38 YFNKKYRYGNFDRYYGI...RLNPGESDKRLS------------------VFQ.KDWFEH.KQ..
  39 -----------------...-------------------------KLELVSRK.LDLSPG.RR..
  40 YFNKKYRYGNFDRYYGI...RLNPGESDKRLS------------------VFQ.KDWFEH.KQ..
  41 -----------------...----------RR----------------AAAAE.ALAHSP.RR..
  42 -----------------...---------------------AQLAKVDLALDK.LNLEPG.MT..
  43 -----------------...-----------------------------LAGA.LDWTEY.SS..
  44 IVVKPLWEEYTPKDYEL...MLNMDPGMAFGT-------GTHETTRMCIQALE.RYVNED.AE..
  45 -----------------...-------SLAPTYDKINGILSLGLHIAWNNALV.SLLGET.NH..
  46 IVVKPLWEEYTPKDYEL...MLNMDPGMAFGT-------GTHETTRMCIQALE.RYVNED.AE..
  47 -----------------...--------LAPTYDKINKILSLGLHLTWNHSFV.SLLGRS.DH..
  48 -----------------...------------EAQQKWLGRDHLITPTIKKAF.GHILVG.KE..
  49 --KYDRFAALYDKFESF...IEKKFFSRFREELFKR-----------------.---VEG.KK..
  50 -----------------...----------------------QRQSADALLAM.LPQRKY.TH..
  51 -----------------...----------------------QRQSADALLAM.LPQRKY.TH..
  52 MMTDAWNAEQYRDRHAF...VFQSSEDLAAEW---------------------.LRPQPG.ER..
  53 -----------------...------------------------------FLF.LENKKA.LR..
  54 -----------------...-------------------------AALALAAA.LDVPPT.GR..
  55 -YLDQLATTDAARSYKS...V----------------------------MLDA.LDARPG.ES..
  56 -----------------...---------------------------------.------.--..
  57 -VVKPLWEEYTPKDYEL...MLNMDPGMAFGT-------GTHETTRMCIQALE.RYVNED.AE..
  58 -----------------...---------FAA---------------------.--MAPG.ET..
  59 ---------------RF...FELIGSNEQFAEMFNRAMSEASTLIMKKVLEVY.KGFEDV.NT..
  60 -----------------...-------------------------FLGHFILL.GGVRPE.SR..
  61 -----------------...--------------------------VDLNLDK.LDLKPG.MT..
  62 -RESENFYDRIASQFDH...SFDGFLASFFKR----------------FILKN.LKFEQN.SK..
  63 ------------DFWDL...RLSSSFNKIYRD----------------VIVNL.GEINRE.SY..
  64 ------------DFWDI...RLSSSFNKTYRD----------------AIINL.GEIRED.SY..
  65 -----------------...-----YYRAFPTYTDINSQEYRDRLENLEPLLM.KYMKRR.GK..
  66 -----------------...--------------------------VDLNLDK.LDLKPG.MT..
  67 -----------------...----------------DHMDTFNQFVVAELSKA.LDWSRW.KT..
  68 -----------------...---EN----------------------SAAYLL.GSLRPH.MR..
  69 -----------------...----------------KLMTASQPLVAREVIAA.YRFGRH.KV..
  70 --NNTLYEAQINKIEH-...-----------------------------TLKK.LDLKEG.EK..
  71 -----------------...-------ERFHQ----------------LPLEN.LAISPG.QK..
  72 -----------------...-------ASFDDEPDHGLRDAEVRRAWAARLAS.WLPAPP.GD..
  73 -----------------...---------------------QPLVEEA-IART.LDRNAP.VR..
  74 -----------------...---GSEAEAFHRMGSQASHRYDEFVDLLVGAGI.A---DG.QT..
  75 -----------------...----------YFLFEEKFRGSRELVKARLRRYI.PYFKGC.RR..
  76 --------EELYKYLRW...RMDPEDKRAVER--------FHRIVEVFEKLKD.SKLISG.SR..
  77 MMNRPVVKAELVEWMRSsqtQVTGELAEVLNFAKENNIPVIPHETVLY-FQML.LSLLKP.KR..
  78 --------------KKY...WIEHSVDLTVEAMMLDSQASDLDKVERPEVLSM.LPPYEG.KS..
  79 -------YEDLDRARQI...MLH---------------MDAHNGFTADELARA.IDWSRY.TS..
  80 -----------------...-----YYRVFPTYTDINSQEYRSRIETLEPLLM.KYMKKR.GK..
  81 ------------EYYDT...IYRRRIERV-----------KAEIDFVEEIFKE.DAKREV.RR..
  82 -YDKDNFFELYQKLRA-...----------------NPISLNEIIEKPTMLSL.LPNLKG.KK..
  83 -----------------...-------QTYQQLVDHNYMAHRQIHQAVGALIQ.QQFDRP.FD..
  84 ------QYKKIDR----...-----------------------------LIDQ.LELKAD.DH..
  85 -----------------...---------------------LQRDVGERLLGM.GSSHPG.EQ..
  86 -----------------...---------------------------------.------.--..
  87 -----------------...---------------------------------.--LGNK.SK..
  88 LYEGSLVTARYRRDGKV...IT-------------------------------.--DLEN.RV..
  89 -----------------...----------------------RSRPAVELLAR.VPLENV.EY..
  90 -----------------...--------------------AWRTPETCSTYML.KYVKKT.DR..
  91 -----------------...--------------------------TKDIVKR.INLSSS.DE..
  92 -----------------...-------RTYDEDVEREDWIHADYEEVLKLVAE.RV---G.GT..
  93 -----------------...---------------------------------.-----G.QN..
  94 -----------------...--------------------------FYKMIDE.YHDGER.KL..
  95 -----------------...------------------------------GIN.APEVEN.SK..
  96 -----------------...------------------------------GIN.APEVEN.SK..
  97 LYEDDDVEELVERDELS...RTYCPVCSSRDTVPLNFISHSLSRLQVKFLFDL.LMPPTC.QH..
  98 -----------------...--------------------------------I.PPALEG.AT..
  99 -----------------...---------------ASAPYIQELATICQQLAQ.R-LQRP.VR..
 100 -----------------...---------------------SSPWLCNRMAGL.ADWTQA.TT..
 101 -----------------...---------------ASAPYIQELATICQQLAQ.R-LQRP.VR..
 102 -----------------...---------------ASAPYIQELATICQQLAQ.R-LQRP.VR..
 103 -----------------...--------------------GRDRMRTTLLSWL.PQDLRG.RR..
 104 -----------------...------------------------APARDLQAL.IPERPY.AQ..
 105 -----------------...----------------------KTHRRSLEWLL.ARLAPG.SR..
 106 -----------------...-------------AQQKWLYQDHLVLPTLEKLL.KYNLKD.KK..
 107 -----------EESPVW...PLGIEDDEFIQRKPDKGLITKKEIRTL--SISA.LQLKRD.SV..
 108 ------------RVFDI...---------------------------------.--KREF.KA..
 109 -----------------...-------------------------LVLFLSKI.KPPKRN.YR..
 110 -----------------...----------------DVLGSNNFLRKLKSRML.PQENNV.KY..
 111 -----------------...-----------------------------LLQN.EAVVRG.KT..
 112 -----------------...----------------SLLTDYERLAIFKNAIE.RVVDED.DV..
 113 -----------------...------------------------AMLALSCER.AKVEDG.QS..
 114 -----------------...-------------------------EYLDLLAH.APSTGF.QT..
 115 -----------------...-------------------------EYLDLLAH.APSTGF.QT..
 116 -----------------...--------------------------LNRLNYR.IGKIEN.LV..
 117 -----------------...------------------------ELIPKILEL.LDLKED.DV..
 118 -----------------...--------------------------VRRMLEI.AKASQD.DI..
 119 -----------------...-----------------------RLAA--FREA.ISSRAR.GL..
 120 -----------------...-----------------------------LVSV.ANQIPQ.GK..
 121 -----------------...---------------------------------.--LFYE.AS..
 122 -----------------...-------------------------------LS.RALGRP.LN..
 123 -----------------...-------------------------------GR.KPSTDN.IR..
 124 -----------------...--------------------------------M.EEPPDR.LH..
 125 MMLDSLKRHPNPKADLE...QYTIDGKLAADI-----------------LFFA.VNDFYN.NV..
 126 MHNKKLIEEIVDRANIS...I--------------------------------.-----D.DT..
 127 MHNKKLIEEIVDRANIS...I--------------------------------.-----D.DT..
 128 MHNKKLIEEIVDRANIS...I--------------------------------.-----D.DT..
 129 MHNKKLIEEIVDRANIS...I--------------------------------.-----D.DT..
 130 -----------------...-----------------------------AAYL.LKLENN.QT..
 131 -----------------...-----------------------RRVISRIVGY.AELSED.DV..


         60        70           80        90       100              110
         |         |            |         |         |                |
   1 ...VYDLGCSRGAATLSARR...NINQPNVKIIGIDNSQPMVERCRQHI.....AAYH.SE.IPV
   2 ...VYDLGCSRGAATLSARR...NINQPNVKIIGIDNSQPMVERCRQHI.....AAYH.SE.IPV
   3 ...VYDLGCSLGAATLSVRR...NIHHDNCKIIAIDNSPAMIERCRRHI.....DAYK.AP.TPV
   4 ...VCDLGCSSANFLIFLAN...LR--KDFKLFGVDNSASMLEVAKSKA.....KAYG.L-.-DI
   5 8plIYDLGCSTGNFFIALNQ...QIQ-QDIELVGIDNSMPMLKKAQEKL.....KDFN.--.-NV
   6 8plIYDLGCSTGNFFIALNR...QIQ-QEIELVGIDNSMPMLKKAQEKL.....KDFN.--.-NA
   7 ...IFELGCGVGNTILPLLQ...YSSEPQLKVFGCDFSARAIEILRSQR.....QFDE.K-.-RC
   8 ...ILDLCCGTGDWTFDLSE...SVG-PSGKVIGLDFSENMLEIAKAKL.....KEEA.KK.-NI
   9 ...ILDLCCGTGDWTFDLSE...SVG-PSGKVIGLDFSENMLEIAKAKL.....KEEA.KK.-NI
  10 ...VLDIGCGAGNNTLRLRQ...SAN-YDFNVDLLDLSAPMLMKAAERV.....QQLN.RG.-LV
  11 ...ALDVCCGTADWTIALAE...AVG-PEGKVYGLDFSENMLKVGEQKV.....KARG.LH.-NV
  12 ...ILEVGCGAGNTIFPLIA...TY--PDIFVYACDFSPRAVELVKAHD.....EYTE.T-.-RV
  13 ...VLDVGCGVGGPAREITE...FT---GCNLVGLNNNDYQISRCNNYA.....VKRN.LD.KKQ
  14 ...VLDVGCGVGGPAREITE...FT---GCNLVGLNNNDYQISRCNNYA.....VKRN.LD.KKQ
  15 ...VLDVGCGVGGPGREITR...FT---DCEIVGLNNNDYQIERANHYA.....KKYH.LD.HKL
  16 ...VLDLGCGTGASTAALLA...AA--PRARITGVDASAGMLDRATAKS.....WPQG.--.--V
  17 ...IFEIGCGAGNTFFPILK...DNENENLRIIAADFAPRAVELVKNSE.....QFNP.K-.-YG
  18 ...VLDVGCGIGGGDFYMAE...NF---DVDVVGIDLSVNMISFALEH-.....-AIG.LK.CSV
  19 ...VLDIGCGRGACLFPAAE...KVG-SQGCVHGIDIAPGMIEEARKEA.....TERG.LR.-NI
  20 ...VLDIGCGRGACLFPAAE...KVG-SQGCVHGIDIAPGMIEEARKEA.....TERG.LR.-NI
  21 ...LLDLGCGTGASTRALLR...AA--PRARITAVDASAGMLRRALVK-.....-PWP.A-.-RV
  22 ...VLDIGCGRGACLFPAAE...KVG-PQGRVHGIDIAPGMIEEARKEA.....AERG.LR.-NI
  23 ...VLDVGCGRGACVFPAAE...RVG-PEGRVVGIDVAEAMIEEATKEA.....ALRD.AA.-MV
  24 ...ILEVGCGVGNTVFPILQ...TNNDPGLFVYCCDFSSTAIELVQTNS.....EYDP.S-.-RC
  25 ...LLEIGCGNGSTVLPILR...GS--KNITVYACDCSSDALVRTKENId....RAIS.SV.DNF
  26 ...VLEVACNMGTTAIGLAK...QF---GCHIEGVDLDENALAKAQANI.....EANG.LQ.EKI
  27 ...VLDVGGGKGGFAAAIAR...RA--PHVSATVLEM-AGTVDTARSYL.....KDEG.LS.DRV
  28 ...ILEVGCGVGNLVYPLLE...VQ--PNLKIYCCDFSPRAIDFVKKHS.....CYNE.N-.-RV
  29 ...ILEVGCGVGNTVFPILQ...TNNDPGLFVYCCDFSSTAIELVQTNS.....EYDP.S-.-RC
  30 ...VLDVGGGKGGFAAAIAR...RA--PHVSATVLEM-AGTVDTARSYL.....RDAG.LS.DRV
  31 ...IADIACGTGDMIEIWQEsalKMEKNILNIKGIDPSSGMLNVAKEKF.....P---.--.-NV
  32 ...LLDVGCGWGGALVRAVE...KY---DVNVIGLTLSRNHYERSKDRL.....AAIG.TQ.RRA
  33 ...ILEIGCGAGNTIWPILK...ENKNSNLKIFAVDYSEKAIDVVKQNP.....LY-D.AK.-FC
  34 ...VLDLACGFGFFGREIYR...R---GAAKVVGVDISEKMIELAREES.....RKYG.D-.-PL
  35 ...VLDLGCGVGTPGVRIAR...L---SGAHVTGISVSHEQVVRANALA.....EEAG.LA.DRA
  36 ...VLDVGCGIGGGDFYMAE...NY---DVEVVGIDLSINMISFALER-.....-SIG.LK.CAV
  37 ...VLDVGCGRGACLFPAAR...RVA-PDGYALGIDIAPAMVEEAAAEA.....ERLG.MP.-HV
  38 ...ALDIGCNAGFLTLSIAK...DF--SPRRIIGIDIDEHLIGVARKNI.....RHYC.--.-DH
  39 ...LLDVGCGWGSMAIHAAR...EH---GVSVVGVTLSQEQAAYARKRV.....ADEG.LT.DRV
  40 ...ALDIGCNAGFLTLSIAK...DF--SPRRIIGIDIDEHLIGVARKNI.....RHYC.--.-DH
  41 ...VLDVATGTGDFAIELKE...RA--PQVEIVGSDFVPQMLDLARQKA.....GAKQ.L-.-SI
  42 ...LLDVGCGWGGALVRAVE...KY---DVNVIGLTLSRNHYERSKDRL.....AAIG.TQ.RRA
  43 ...FVDLGGARGNLAAHLHR...AH--PHLRATCFDL-PEMEPFFQEHM.....KSLE.TT.DQV
  44 ...VFDIGTGSGILAIAAAK...L---NAKKVLGVDLDSVAVKAAKENI.....QYNN.VN.-NI
  45 ...LLDLCAGTGRVALSYVQ...NY--PRASATLVDFSTKMLENVQKRH.....PSAP.--.--F
  46 ...VFDIGTGSGILAIAAAK...L---NAKKVLGVDLDSVAVKAAKENI.....QYNN.VN.-NI
  47 ...LLDLCAGTGHVALSYIQ...KY--PQASATLVDFSTKMLENVQECH.....PLAP.--.--F
  48 ...VLDVGCGNGHYSFDFLR...W---GAHKVFGVDNSEEMIQICKSSP.....DFEN.FN.SKI
  49 ...ILEVGIGTGKNVPYYS-...----DDMDVVGVDISEGMLRVCQERL.....KKFP.EK.-KV
  50 ...VLDAGCGPGWMSRHWRE...R----HAQVTALDLSPPMLVQARQKD.....AADH.--.---
  51 ...VLDAGCGPGWMSRHWRE...R----HAQVTALDLSPPMLVQARQKD.....AADH.--.---
  52 ...ILDLGCGSGELTARIAQ...S----GAQVVGVDASPAMIAAAQSSF.....P---.--.-AV
  53 ...LVDVACGTGDMLVAWQKsalNCGIEFKECLGIDPSNNMLELAIKKC.....EELE.N-.-KA
  54 ...VLDVATGTGTVALTLAP...K----VAEVMGTDIAPAMIEQARQRA.....AGRS.--.-NV
  55 ...ALDLGCGPGTDLGTLAK...AVS-PSGRVIGIDSSQEMVEQARRRT.....ENLP.--.-AV
  56 ...-CDLGGGAGALAKECMS...LY--PGCKITVFDI-PEVVWTAKQHF.....SFQE.EE.-QI
  57 ...VFDIGTGSGILAIAAAK...L---NAKKVLGVDLDSVAVKAAKENI.....QYNN.VN.-NI
  58 ...VLDLGSGAGFDCFLAAQ...EVG-PDGHVIGVDMTPEMISKARENV.....AKND.AE.-NV
  59 ...LVDVGGGIGTIIGQVTS...KY--PHIKGINFDL--------ASVL.....AHAP.FN.KGV
  60 ...VLDIGCGIGRMAVPLTQ...YLDFEKGHYSGIDPVEGGIGWCRRFI.....TSVY.P-.-NF
  61 ...LLDIGCGWGTTMRRAVE...RF---DVNVIGLTLSKNQLARCEQVL.....ASID.TN.RSR
  62 ...ILDIGCANGKLLAMLND...K---KKIVGSGLDISSEMIKVAKAQY.....P---.--.-YF
  63 ...VLDLGCGSVSPSYFGKF...IS--EDGKYLGVDYSPGLLEIARQRV.....EREG.L-.-PV
  64 ...ILDLGCGSVSPAYFGKF...IS--EDGKYVGVDYSPGLLEIARERV.....ERNG.L-.-PA
  65 ...VLDLACGVGGFSFLLED...Y----GFEVVGLDISEEMISKAKMYA.....KEKS.S-.-NV
  66 ...LLDIGCGWGTTMRRAVE...RL---DVNVIGLTLSKNQHARCEQVL.....ASID.TN.RSR
  67 ...FVDVGGARGNVAAQLVL...DH--PDLKGSVFDV-PGVEPLFDEHM.....AARG.TT.GRV
  68 ...ILDIGCGPGTITADLAE...RV--PEGHVTGVDRSPEIVERARATA.....AARG.LE.-NT
  69 ...LMDVGGGEGAFVRCVAA...EV--PGVELRVFDL-PAVAERANENF.....QRWG.LA.GRA
  70 ...LLDIGCGWGWLSIMAAQ...KY---GVKVVGITISEEQCKKAKERV.....KELG.LE.DKI
  71 ...VLDLCCGGGQATVYLAQ...S----GATVVGLDASPKALGRAKINV.....P---.--.-QA
  72 ...VLDLGCGTGSLSLLAAE...Q----GHRVTGVDLSPAMVELARTKL.....AGRD.--.--A
  73 ...LLEVGCGSGTYVRYAAE...LN--PRLSALAVDLQQDVADSAAANM.....AEWG.LT.DRV
  74 ...VVDLCCGSGELEVILSS...RF--PSLNLVGVDLSEDMVRIAREYA.....AEQG.K-.-AL
  75 ...VLDIGCGRGEFLELCKE...E----GIESIGVDINEDMIKFCEGKF.....NVVK.SD.-AI
  76 ...VLDICAGTGIAGVALAK...VL--NAKKLTVLDVRREDLDKVEKWM.....EVAG.ID.VEV
  77 ...ILEIGTAIGFSALVMAQ...EV--PEAEIVTIDRNPEMIELAKKNL.....AKYD.HR.NQI
  78 ...VLELGAGIGRFTGELAE...K----ASQVIALDFIESVIKKNESIN.....GHYK.--.-NV
  79 ...FVDVGGGRGNVASRIVT...AH--PHLRGGVFDL-PALRPLFEELV.....ASAG.TA.DRV
  80 ...VLDLACGVGGFSFLLED...Y----GFEVVGVDISEDMIRKAREYA.....KSRE.S-.-NV
  81 ...VLDLACGTGIPTLELAE...R----GYEVVGLDLHEEMLRVARRKA.....KERN.L-.-KI
  82 ...LLDLGCGTGGHLQLYLE...R---GAAKVIGTDLSEKMLEQAEKDL.....QKCGqFS.GRF
  83 ...FLDLGCGDAQAIAKTLT...GS--KINSYTGVDLSPNALALAQKNL.....DPFR.--.-QV
  84 ...VLEIGCGWGAAAIRAVQ...R---SGCKWTGITISKEQLEWGQKKV.....VEAG.LE.GRI
  85 ...LLDAGCGTGYFSRMWRE...R----GKRVTALDLAPGMLDVARQRQ.....A---.--.-AH
  86 ...-LDVGCGSGRMALPLTG...YLN-SEGRYAGFDISQKAIAWCQEHI.....TSAH.P-.-NF
  87 ...VLYVGVGGGLEALQFAY...FCR-QPGAVIAVDPVEAMRQAAQRNLql7knDWFS.VD.-FV
  88 ...MLDVACGTGATTLTMAL...AN--PGAKVVGIDISPESIKIAEERL.....QYHK.ID.-NS
  89 ...VADLGCGPGNSTALLQQ...RW--PAARITGIDSSPAMIAEARSAL.....P---.--.-DC
  90 ...ILDVGCGPGTITVGFPK...YV--PEGEVIGVEPSQELLDKAEEALrk6tlKKEK.IN.-NC
  91 ...LLDLGCGDGVLTNELVS...Q----CRRVVGIDASPDMIKAAREL-.....-GLN.AY.VIP
  92 ...VVDIGCGTGNILCFL--...----KCERYIGVEPSRGMRAKFKEKH.....GFEP.LD.---
  93 ...ILEVGCGGGLLTEHLAR...L----GAQVAGIDLGEKLIEAAREHL.....KCSS.PE.-LA
  94 ...LVDVGCGPGTATLQMAQ...ELK-PFEQIIGSDLSATMIKTAEVIK.....EGSP.DTyKNV
  95 ...ILELGCAAGGNLIPHAV...LY--PNAHFVGVDLSKVQIDEANKNV.....RALG.LK.-NI
  96 ...ILELGCAAGGNLIPHAV...LY--PNAHFVGVDLSKVQIDEANKNV.....RALG.LK.-NI
  97 ...VLDIGSRLGAIVYGASI...FTN-GNVSTIGVEMDSDYAALALRTI.....RQFG.LK.-NI
  98 ...VLDLGSGSGRDVYVLSQ...LVG-PTGRVIGVDMTEEQLAVARRHQdwha.ERFG.HA.-NT
  99 ...LLEVGTRTGRAAESLLA...QLNAGQIEYVGLEQSQEMLLSARQRL.....APWP.GA.-RL
 100 ...VAELGAGDGVLTRRLLD...RMA-PDTQLDAWEIQPELVGQLRSLA.....EHDH.--.-RL
 101 ...LLEVGTRTGRAAESLLA...QLNAGQIEYVGLEQSQEMLLSARQRL.....ASWP.GA.-RL
 102 ...LLEVGTRTGRAAESLLA...QLNAGQIEYVGLEQSQEMLLSARQRL.....ASWP.GA.-RL
 103 ...VLDAGCGTGAASIELAR...R----GAEVVAIDLSPTLVGYARERL.....PESL.GP.GSI
 104 ...VVDLGCGTGEQTAQLAQ...RF--PQATVLGLDSSAAMLAKAGAQ-.....-QLP.--.-NL
 105 ...VLDVGSGTGRPTAETLA...GA---GHEVLGVDVSPVMVELAARQV.....P---.--.-AA
 106 ...VLDIGCGNGLNSTTFLQ...W---GARKVVGFDNSQEMIENCKNLH.....KSSE.--.-QS
 107 ...VWDIGTCTGSVAIEAAK...IA--REGQIFAVEKNEADLENCRENL.....AKFR.V-.-DA
 108 ...AADIGCSRGYLSRHILA...E---SVEQLTLTDTSATMLEQAQGTP.....G---.L-.-KM
 109 ...IIDLGAGFGFLSITLAK...KY---GVKVVAFEYDERMVKLLRKNV.....KLNG.VE.HLV
 110 ...AVDIGAGIGRVSKTMLH...KH---AAKIDLVEPVKPFIEQMHVEL.....AELK.DK.GQI
 111 ...VLDVGCGTGILSIFASK...A---GAARVVGIDN-SDIVYTAMDII.....RKNK.VE.-NV
 112 ...VFDLGTGSGILAMIAAK...K----AKKVYAIELDPFTYDYAKENI.....KVNG.FN.-NI
 113 ...VLDIGCGWGSLTLYIAR...KY--SKCKLTGICNSKTQKAFIDEKC.....RKLG.LQ.-NV
 114 ...AFDIGTGSGVLAAILAK...Q---GIPSVIGTDTNPKAVACARANI.....ARLG.FE.KQV
 115 ...AFDIGTGSGVLAAILAK...Q---GIPSVIGTDTNPKAVACARANI.....ARLG.FE.KQV
 116 ...AADCGAGIGRVTENVLL...KI---ASHVDLVEPVENFISTAKKQL.....A---.-T.KPC
 117 ...FYDLGCGDGRVVIEAVK...KT--RVKKAVCVETRDDLVKEARKKA.....EEEG.VS.DRI
 118 ...VYDLGCGDGRIIITAVK...DF--NVKKAIGVEINDERIREALANI.....EKNG.VT.GRA
 119 ...TYDLGAGSGILSFFASE...Y----ADRVIAIERDPKIAACAGENL.....SGLD.--.-NV
 120 ...ILCLAEGEGRNACFLAS...L----GYEVTAVDQSSVGLAKAKQLA.....QEKG.V-.-KI
 121 ...VLDIGCNNGTVSAQIAS...IF--GASFVLGLDIDHVLIQKARKHL.....E---.--.-FV
 122 ...VLDLGCAQGFFSLSLAS...K----GATIVGIDFQQENINVCRALA.....EENP.DF.-AA
 123 ...ILDAGCGTGVGTEYLIH...LN--PAAEIVGIDLSEGALEVAEKRC.....QQSG.VR.DRH
 124 ...VLDVGSCFNPFSSA---...----PHLEVTALDLCPATEDVLQADF.....LKVE.VV.PGI
 125 ...VIDLGCGTGRLAIGSKI...L---GAKRAIGIDIDRESIEAAKENA.....KKLN.V-.-DV
 126 ...VLELGAGKGALTTMLSQ...K----AGKVLAVENDSKFVAILTRKT.....AQHP.--.-NT
 127 ...VLELGAGAGALTTVLSQ...K----AGKVLAVENDSKFVDILTRKT.....AQHS.--.-NT
 128 ...VLELGAGKGALTTVLSQ...K----AGKVLAVENDSKFVDILTRKT.....AQHS.--.-NT
 129 ...VLELGAGKGALTTVLSQ...K----AGKVLAVENDSKFVDILTRKT.....AQHS.--.-NT
 130 ...VLDACAAPGSKTSHILE...VNP-HLKTLVAIDNNKQRLNRIKENI.....TRLG.L-.-RQ
 131 ...VLEVGCGTGNLTSALLR...K-----CSVVGIEKDPLMVKRLRERF.....SDFI.GK.GRF


                      120                130           140       150   
                       |                  |             |         |   
   1 ....EILCNDIRH.....VEI.....KNASMV....ILNFTLQFLPP....EDRIALLTKIYE..
   2 ....EILCNDIRH.....VEI.....KNASMV....ILNFTLQFLPP....EDRIALLTKIYE..
   3 ....DVIEGDIRD.....IAI.....ENASMV....VLNFTLQFLEP....SERQALLDKIYQ..
   4 ....SFFEANLCE.....FDF.....FTCDVF....VANYTMQFIRP....PKRQELLDQIYK..
   5 ....RFECMDFLE.....VKF.....KEASAF....SLLFVLQFVRP....MQREVLLKKIYN..
   6 ....RFECMDFLE.....VEF.....KEASAF....SLLFVLQFVRP....MQREVLLKKIYN..
   7 ....EVFVMDATL.....DHWqv6eeNSQDII....VMIFVLSAIEP....KKMQRVLDNCYR..
   8 ....EFLQGNAMA.....LPFek...GSFDVV....TIGYGLRNTP-....-DYLTVLKEIFR..
   9 ....EFLQGNAMA.....LPFek...GSFDVV....TIGYGLRNTP-....-DYLTVLKEIFR..
  10 ....RTIQGDFRS.....VSLpn...STYDVL....IAAAVLHHLRDd...EDWRQAFQKIYN..
  11 ....KLIHGNAMQ.....LPFpd...NSFDYV....TIGFGLRNVP-....-DYMTVLKEMHR..
  12 ....CAFACDLTG.....DGLdk6spSSVDIV....TMIFVLSAVSP....EKMSSVLQNIRK..
  13 ....VFVKGDFMH.....MPFed...NTFDYV....YAIEATVHAP-....-SLEGVYGEIFR..
  14 ....VFVKGDFMH.....MPFed...NTFDYV....YAIEATVHAP-....-SLEGVYGEIFR..
  15 ....SYVKGDFMQ.....MDFep...ESFDAV....YAIEATVHAP-....-VLEGVYSEIYK..
  16 ....DFVHLPVEE.....LAGrlea.GSFDAV....FAGYLFRNLT-....-DPDEALDMLHG..
  17 ....HATVWDLAN.....PDGnl8epHSVDIA....VMIFVFSALAP....NQWDQAMDNLHK..
  18 ....EFEVADCTK.....KEYpd...NTFDVI....YSRDTILHIQ-....-DKPALFRRFYK..
  19 ....SLMVMDAET.....PGFpa...RSFDLV....MGSYSVIFLP-....-DAVGALARYAD..
  20 ....SLMVMDAET.....PGFpa...RSFDLV....MGSYSVIFLP-....-DAVGALARYAD..
  21 ....RFLHLTAEE.....FATtredeGPFDAV....FAAYLFRNVT-....-DPDAVLRAVRQ..
  22 ....ALDVMDAET.....PELpa...RSFDLV....MGSYSVIFLP-....-DAVGALARYAG..
  23 ....ELRVMDGEH.....PDFap...HSFDVV....LGSYSVIFLP-....-DAPTALARYAP..
  24 ....FAFVHDLCD.....EEKsy6pkGSLDII....ILIFVLSAIVP....DKMQKAINRLSR..
  25 ....HSFCCDFSTs27skH--ci...GGVDFV....TLIFTLSAVPK....ERMPRAIKECFA..
  26 ....HVQRANAMK.....LPFed...ESFDIV....INEAMLTMLPV....EAKKKAIAEYFR..
  27 ....DVVEGDFFE.....PLP.....RKADAI....ILSFVLLNWPD....HDAVRILTRCAE..
  28 ....FPFVNDITE.....DSLle6gsACIDTL....TAIFVLSAIPR....EKQLRSIKNLAS..
  29 ....FAFVHDLCD.....EEKsy6pkGSLDII....ILIFGLSAIVP....DKMQRAINRLSR..
  30 ....DVVEGDFFE.....PLP.....RRADAI....ILSFVLLNWPD....HDAVRILTRCAE..
  31 ....EFIKAGAQN.....LPLes...QSLDIL....SISYGIRNVV-....-ERQKALSEFAR..
  32 ....EARLQGWEE.....FE-.....ENVDRI....VSFEAFDAFKK....ERYLTFFERSYD..
  33 ....SASVWDLAG.....SDLlr6eeASIDAI....TLIFCFSALSP....DQWQQAIENLYR..
  34 ....EFHVRDVAN.....MEPl....GQFDLV....NAAWLFNYADSv...ENLRKMFKVVRA..
  35 ....RFQRADAMD.....LPFed...ESFDAV....IALESIIHMP-....-DRAQVLAQVGR..
  36 ....EFEVADCTK.....KDYpe...NSFDVI....YSRDTILHIQ-....-DKPALFRSFHK..
  37 ....EVRVMDGER.....PALpe...RSFERV....LGSYSVIFFP-....-EALPALVRYAG..
  38 ....ETEVSGKFPa42emLDMiq...PEFDVIlalsITKWIHLNWGD....DGMRRFFRRAYA..
  39 ....EIRVQDYRD.....VAD.....GPYDAI....SSIGMAEHVGA....ERYLEYATDLHR..
  40 ....ETEVSGKFPa42emLDMiq...PEFDVIlalsITKWIHLNWGD....DGMRRFFRRAYA..
  41 ....RFEEGDALR.....LPYpd...ASFDAV....TCAFGFRNFA-....-DYTQGLAEMWR..
  42 ....EARLQGWEE.....FE-.....ENVDRI....VSFEAFDAFKK....ERYLTFFERSYD..
  43 ....RFAGGDFFT.....DPL.....PRADVF....IVGHILHYFGL....RQREALIARIHQ..
  44 ....EILHGNLME.....VVQ.....GKADII....VANIIADVIN-....----ILIPDINK..
  45 ....SYITSDVTH.....LPLpd...NTFRLA....SMAYGLRNLS-....-YPLEALREVYR..
  46 ....EILHGNLME.....VVQ.....GKADII....VANIIADVIN-....----ILIPDINK..
  47 ....SYVISDVTS.....MPLpn...DTFHLA....SMAYGLRNLS-....-SPLEALKEVHR..
  48 ....DFLLGEVTN.....FHVdg...ASFDVA....TAFFVLQFLHKn...DDVALAIQNISR..
  49 ....KLLRADVQN.....LPFsd...GEYDCV....VSTFVFCTVP-....-DPVKGLKEVHR..
  50 ....-YLAGDIES.....LPLat...ATFDLA....WSNLAVQWCG-....-NLSTALRELYR..
  51 ....-YLAGDIES.....LPLat...ATFDLA....WSNLAVQWCG-....-NLSTALRELYR..
  52 ....PFEVQDAHA.....LTFg....SEFEAV....FSNAALHWMK-....-PLPPVFGRVAA..
  53 ....SFIQAQAKD.....LKGven..NSVDIL....SIAYGLRNVV-....-ERQEALKEFFR..
  54 ....QFVLAEATA.....LTFad...QSFDVV....VCGAGLFFVP-....-DMVAALREWRR..
  55 ....EVELGDIHT.....LPLed...GSIDCA....RTDRVLQHVA-....-DPAQALAEARR..
  56 ....DFQEGDFFK.....DPL.....PEADLY....ILARVLHDWAD....GKCSHLLERIYH..
  57 ....EILHGNLME.....VVQ.....GKADII....VANIIADVIN-....----ILIPDINK..
  58 ....EFRLGEIGH.....LPVad...ESVNVV....ISNCVVNLAP-....-EKQRVFDDTYR..
  59 ....EHVSGDMFK.....-EI.....PKGDAI....FMKWILHDWTD....EDCVKILKNYWK..
  60 ....AFQRVDIAHe15lkLPYad...GHFDFV....IMTSIVTHLPP....DEVLVYLREVGR..
  61 ....QVLLQGWED.....FA-.....EPVDRI....VSIEAFEHFGH....ENYDDFFKRCFN..
  62 ....TFEQGSAQE.....IPFdn...ESFDLI....ICSASFHHFP-....-KPERFLLEAEC..
  63 ....ELKEMDVSL.....IKPr....TKYDVA....IMSFLLEYVK-....-DRREVLRKVLE..
  64 ....ELKEMDVSL.....IRTr....SKYDVA....IMSFLLEYVR-....-DREEVLGKVLE..
  65 ....EFIIGDAKK.....LPFed...NNFDYV....IFIDSLVHFSP....LELNQVFKEVKR..
  66 ....QVLLQGWED.....FA-.....EPVDRI....VSIEAFEHFGH....ENYDDFFKRCFN..
  67 ....DFVGGDFFT.....DAL.....PAADVV....LFGHVLHDHPE....ESRKRLLGQAFR..
  68 ....GFAVADVHA.....LDYpd...DTFCVV....HAHQVLQHVG-....-DPVRALREMRR..
  69 ....QAFGGDFFA.....DELp....RGADVI....SLVRVAFDHPD....ERVLTLFKNVRR..
  70 ....EIRLQNYQD.....LEFe....NYFDKV....VSVGMFEHVGK....ENLGLYFMKVKQ..
  71 ....TYVQGLAED.....LPFge...GEFDLV....HTSVALHEMTP....AQLQSIISGVHR..
  72 ....VFLTGDAAA.....PPVge...QRFDAV....LVRHVLWTLP-....-DPGRALRHWRQ..
  73 ....ETRQADLRT.....LDAq....PQFDLV....TLHNNIYYFPE....AERVEALRRAHD..
  74 ....EFRHGDAQL.....LAGmedlaGKADLV....VSRNAFHRLT-....-RLPAAFDTMLR..
  75 ....EYLKS----.....LPD.....KYLDGV....MISHFVEHLDP....ERLFELLSLCYS..
  76 ....EKIVGDAKK.....VGElve..EHDVAV....LFGLTMPHFNA....FDAVKLFAGVAS..
  77 ....QLKEGDAAD.....VLQelk..GPFDLV....FMDSAKS----....-KYVEFLPKSLE..
  78 ....KFMCADVTS.....PSLnisp.NSVDII....FSNWLLMYLSD....EEVERLVERMLK..
  79 ....DFHGGDFFA.....TDL.....PEADVV....IFGHVLPDWPV....GDRRELLRRAHK..
  80 ....EFIVGDARK.....LSFed...KTFDYV....IFIDSIVHFEP....LELNQVFKEVRR..
  81 ....EFLQGDVLE.....IAFk....NEFDAV....TMFFSTIMYFDe...EDLRKLFSKVAE..
  82 ....SLYHLPIEK.....LAElpe..SHFDVI....TSSFAFHYIE-....-NFPTLLSTIHD..
  83 ....ELRETDFLT.....YLGea7apASFDLI....HVGFSLHHLLP....EEKEQFFAHCFS..
  84 ....ELKFQDYRL.....VK-.....EKYTRV....VSIEMIEAVGE....KYLPQYFQIIND..
  85 ....HYLLGDIEQ.....VPLpd...AAMDIC....FSSLVVQWCS-....-DLPAALAELYR..
  86 ....QFEVSDIYNs15frFPYpd...ASFDVV....FLTSVFTHMFP....PDVEHYLDEISR..
  87 ....DIRAGDAFT.....LPVpd...NSVDVV....AQNCLFNIFEP....EDLSRALKEAYR..
  88 ....EFHVLALED.....LDQlg...QKFDYI....SASDILYLLP-....-DLTLALQQLRA..
  89 ....QFVEADIRN.....WQPv....QALDLI....FANASLQWLP-....-DHYELFPHLVS..
  90 ....SFRLGSIYK.....LPFpd...NTFDIV....NTHQVLVHLQ-....-DPVAALVELKR..
  91 ....GEKLLDASE.....IPS.....ESFDVV....FSNAALHWIMRqp..KNRPIVMKGVSR..
  92 ....----GHFLS.....IPLld...GTADAV....ISTYTFHHVPD....EEKEDAIKEMLR..
  93 ....SNVVYKIEP.....VDQha6ncECYDAV....IVSEVLEHVK-....-DKVSLLEASVR..
  94 ....SFKISSSDD.....FKFlg8dkQKIDMI....TAVECAHWF--....-DFEKFQRSAYA..
  95 ....EFHHCSITD.....IDDsf...GKFDYI....ICHGVISWVPK....IVRDKIFKVCNR..
  96 ....EFHHCSITD.....IDDsf...GKFDYI....ICHGVISWVPK....IVRDKIFKVCNR..
  97 ....EILRDDIRH.....LAHvf...KDNQFI....VMNNVFSFFLSk...TEQEECWEFLHT..
  98 ....DFRHGYIED.....LAGagipdASVDVV....VSNCVVNLSP-....-DKPRVLSEIFR..
  99 ....SLWNADTLA.....AHA.....HSADII....WLNNALHRLLP....EDP-GLLATLQQ..
 100 ....QVISRSAER.....LE-.....RHYDVI....FSCLPLLSIPV....IPRLRILNRVRE..
 101 ....SPWNADTLA.....AHA.....HSGDII....WLNNALHRLLP....EDP-GLLATLQQ..
 102 ....SPWNADTLA.....AHA.....HSGDII....WLNNALHRLLP....EDP-GLLATLQQ..
 103 ....DFRSGDMLD.....PAL.....GRFDHV....IAMDSVIHYDA....PDAVAALSRLAE..
 104 ....RFEQGDIQE.....LS-.....GSFDLL....YSNAALQWLP-....-DHPRLLARLWE..
 105 ....TFRCADIRD.....VPLad...ESFDAV....CVYFSLLQLDR....AEQKDLVRRLVR..
 106 ....SFHHLNVTD.....FQLd....EKFHVA....TAVFVLQYVHDk...EELRKAIRLIW-..
 107 ....HTVHGKAPE.....GLNef...ADPDAV....FIGGTAG----....-GMETILDVCCS..
 108 ....VKLVKDEEQ.....LDFed...NSLDLV....ISSLSLHWVN-....-DLPGCFVRIKQ..
 109 ....EVVEGDIKE.....IEKhlsr.GSFNLV....VSNPPFYPINYs...PNPEPYHFEVYAt1
 110 g...QIYEVGMQD.....WTPda...GKYWLI....WCQWCVGHLPD....AELVAFLKRCIV..
 111 ....ELIKGRLED.....TDLpe...TKYDII....ISEWMGYFLLY....ESMLDSIIYAREn.
 112 ....EIIEGDAST.....YNFk....EKADVV....IAELLDTALII....EPQVKVMN----..
 113 ....EIIAADIST.....FEHe....GTYDRI....FSIEMFEHMK-....-NYGELLKKIGN..
 114 ....EIRETDLFPe13pwLPA.....KPTSAV....ESALYDPESA-....-MLAAFLRDAPK..
 115 ....EIRETDLFPe13pwLPA.....KPTSAV....ESALYDPESA-....-MLAAFLRDAPK..
 116 ....SFINVGLQN.....WTPek...NRYGLI....WNQWCLSHLTD....EDLIAYLSRCCE..
 117 ....EFINNDFFK.....TPL.....KDATAV....YMYLLTSVNE-....----SLKPKLAR..
 118 ....SIVKGNFFE.....VDI.....SEATVV....TMF--------....-----LLTNVNE..
 119 ....SVVNEDALH.....YEF.....SAADTI....ICEMLDTALID....EEQVPVLRRALK..
 120 ....TTVQSNLAD.....FDIva...DAWEGI....VSIFC--HLPS....SLRQQLYPKVYQ..
 121 ....SSRIGPVRNp49lrWESk....RKFKIIlalsVSKWVHLNNHD....EGIIKFFGKISS..
 122 ....EFRVGRIEE.....VIAalee.GEFDLA....IGLSVFHHIVHlhgiDEVKRLLSRLAD..
 123 tapvTFKRLPIEQ.....ATEle...GEFDLI....NCVGVLHHMP-....-D----------..
 124 rep.ELEEGSVRR.....LPA.....SHYECV....IFSLLLEYMPSa...EQRLQCCLQAYD..
 125 ....DFYCMDIRDvdd..---.....------....-----------....------------..
 126 ....KIIHQDIMK.....IHLpk...EKFVVV....SN---------....------------..
 127 ....KIIHQDIMK.....IHLpk...EKFVVV....SN---------....------------..
 128 ....KIIHQDIMK.....IHLpk...EKFVVV....SN---------....------------..
 129 ....KIIHQDIMK.....IHLpk...EKFVVV....SN---------....------------..
 130 ....EHLQCLLADv45sq---.....------....-------YHQ-....-KKLQLLNALWT..
 131 ....RLIQGDALK.....VDF.....PYFTK-....-----------....------------..


               160            170                 180             190  
                |              |                   |               |  
   1 ...GLNPNGVLVLSEK...F.RFED.TKI.....NHL.....LIDLHHQFK.....RANG.YSEL
   2 ...GLNPNGVLVLSEK...F.RFED.TKI.....NHL.....LIDLHHQFK.....RANG.YSEL
   3 ...GLNPGGALVLSEK...F.SFED.AKV.....GEL.....LFNMHHDFK.....RANG.YSEL
   4 ...NLNSKGILIMSEK...I.LYED.AFL.....SKN.....IIELYADYK.....EKQG.YSKF
   5 ...SLALNGVLLVGEK...I.MSED.RIL.....DKQ.....MIELYYLYK.....QNQG.YSHN
   6 ...SLALNGVLLVGEK...I.MSED.RIL.....DKQ.....MIELYYLYK.....QNQG.YSHN
   7 ...YLRPGGLLLFRDY...G.RYDL.AQL.....---.....---------.....RFKS.GKCM
   8 ...VLKPGGRVVCIET...S.HPTL.PIY.....KQA.....FELYFKNVM.....PFLG.KVFA
   9 ...VLKPGGRVVCIET...S.HPTL.PIY.....KQA.....FELYFKNVM.....PFLG.KVFA
  10 ...LLAPGGSVWITDL...V.SHEQ.PAV.....QAM.....MWDRYGDYL.....VSLG.GAEY
  11 ...VTKPGGITVCLET...S.QPTL.FGF.....RQL.....YYFYFRFIM.....PLFG.KLLA
  12 ...VLKPNGCILFRDY...A.VGDL.AQE.....---.....---------.....RFSGkDQRI
  13 ...VLKPGGVFGVYEW...V.MSDD.YDS.....---.....---------.....--SI.PKHR
  14 ...VLKPGGVFGVYEW...V.MSDD.YDS.....---.....---------.....--SI.PKHR
  15 ...VLKPGGIFGVYEW...V.MTDK.YDE.....---.....---------.....--TN.EEHR
  16 ...LLVPGGRLAVHEY...T.LGGS.PVH.....RAV.....WSAVCSLII.....QPAG.RLTG
  17 ...ILKPGGKIIFRDY...G.AYDL.TQV.....---.....---------.....RFKK.NRIL
  18 ...WLKPGGKVLITDY...C.RSPK.TPS.....---.....---------.....----.----
  19 ...ILDHGGRIAFTSP...V.FRAG.TFPflp..PEF.....TPLIPQALL.....EHLP.EQWR
  20 ...ILDHGGRIAFTSP...V.FRAG.TFPflp..PEF.....TPLIPQALL.....EHLP.EQWR
  21 ...LLRPGGRFAAHEY...S.LSGS.PGH.....RAL.....WSAVCRGVV.....IPAG.TLTG
  22 ...ILDHGGRIAFTSP...V.FRAG.TFPflp..PEF.....TPLIPQALL.....EHLP.EQWR
  23 ...LLSPGGRLAFTSP...V.FSDD.TFPflp..PVF.....TELIPRELL.....LDLP.PQWQ
  24 ...LLKPGGMVLLRDY...G.RYDM.AQL.....---.....---------.....RFKK.GQCL
  25 ...VLKPGGLLLFRDY...G.LYDM.TML.....---.....---------.....RFEP.EKRV
  26 ...VLKPNGLLLTHDV...M.LVGN.DHQ.....TIL.....---------.....----.----
  27 ...ALEPGGRILIHER...D.DLHE.NSF.....NEQ.....FTELDLRML.....VFLG.GALR
  28 ...VIKPGGHLVFRDY...C.DGDF.AQE.....K--.....-------FM.....TSGD.PSMI
  29 ...LLKPGGMMLLRDY...G.RYDM.AQL.....---.....---------.....RFKK.GQCL
  30 ...ALEPGGRILIHER...D.DLHE.NSF.....NEQ.....FTELDLRML.....VFLG.GALR
  31 ...VLQKDGILVVLEF...T.KREK.GGF.....IAA.....CRDFYLKNI.....LPSI.GGII
  32 ...ILPDDGRMLLHSL...F.TYDR.RWL.....HEQ.....GIALTMSDL.....RFLK.----
  33 ...LLKPGGLILFRDY...G.RLDL.TQL.....---.....---------.....RAKK.NRIL
  34 ...SLKPDGKLVAYTVdpdF.SLAK.GNF.....AKY.....GVNVLNERA.....WGPG.YRHD
  35 ...VLRPGGRLVLTDF...F.ERAP.LAP.....---.....---------.....----.--EG
  36 ...WLKPGGKVLISDY...C.KSAG.TPS.....---.....---------.....----.----
  37 ...LLADGGRIAFTSP...V.FTED.TFPflp..PVF.....TELIPRSLL.....DTLP.PDWR
  38 ...QLHPGGRLIIEPQ...A.FDSY.KKR.....AKM.....---------.....----.----
  39 ...LLKPGGRLLNHQI...A.RRPQ.RDE.....SSY.....NVDEFIDAY.....VFPD.GELA
  40 ...QLHPGGRLIIEPQ...A.FDSY.KKR.....AKM.....---------.....----.----
  41 ...VLTPGGRLVLLEF...P.PPAS.GLF.....GAV.....FRLYFQHVL.....PRIG.ALVS
  42 ...ILPDDGRMLLHSL...F.TYDR.RWL.....HEQ.....GIALTMSEL.....PIPQ.----
  43 ...ALTPGGAVLVYDR...M.IDDD.RRS.....AAL.....SLLGSLNML.....LTSD.E---
  44 ...FLKTDGYFI----...-.----.---.....---.....---------.....----.----
  45 ...VLQPGGHLGILEL...T.RPAT.YNP.....VYL.....LHKLYLNLV.....VPSV.GRFY
  46 ...FLKTDGYFI----...-.----.---.....---.....---------.....----.----
  47 ...VLKPKGRLGILEL...T.RPAT.YNP.....VHL.....LHKLYLNLV.....VPSV.GRFY
  48 ...HLKSRGTFFGLIP...N.GVPG.VRA.....PEN.....MGLKLGAQIqk6esPFVD.GEVV
  49 ...VLRPSGKAVFLEH...M.RSRK.WYV.....NVI.....LFLMHIFTK.....LLLG.TSML
  50 ...VVRPKGVVAFTTL...V.QGSL.PEL.....HQA.....WQAVDE---.....RPHA.NRFL
  51 ...VVRPKGVVAFTTL...V.QGSL.PER.....HQA.....WQAVDE---.....RPHA.NRFL
  52 ...ALKPGGRFVLEMG...G.AGNVqTTL.....DAV.....AHATHKLGL.....PELP.PPWV
  53 ...VLKPRGVLVILEF...LkKDNP.TWL.....DKI.....SGFYTNKVL.....PLVG.GAIS
  54 ...VLRPGGEVVFSAF...G.RGLL.GPL.....---.....---------.....PGLW.RERL
  55 ...VLRPGGRLVMGEP...D.WDSL.TID.....---.....---------.....--YP.DLEV
  56 ...TCKPGGGILVIES...L.LDED.RRG.....PLL.....TQLYSLNML.....VQTE.GQER
  57 ...FLKTDGYFI----...-.----.---.....---.....---------.....----.----
  58 ...VLRPGGRVAISDV...V.QTAP.FPD.....DVQ.....MDPD-----.....----.----
  59 ...SLPEKGKVIIVEV...V.TPEE.PKIndissNIV.....FGMDMLMLA.....VSSG.GKER
  60 ...LLKPGGRLFMTAF...V.VDHV.AAA.....---.....---------.....NESG.RRDA
  61 ...IMPADGRMTVQSS...V.SYHP.YEM.....AAR.....GKKLSFETA.....RFIK.----
  62 ...LLSPNGRLVIAEI...H.IPFI.TK-.....---.....---------.....----.--IY
  63 ...ALDSGGKLVIVDA...F.RDEF.KNI.....EAM.....---------.....----.----
  64 ...ALDSGGKLIIVEA...F.RDEF.ENI.....QAM.....---------.....----.----
  65 ...VLKPTGKFIIY--...-.----.---.....---.....---------.....----.----
  66 ...IMPADGRMTVQSS...V.SYHP.YEM.....AAR.....GKKLSFETA.....RFIK.----
  67 ...ALPPGGTLLVYDA...M.LDDR.SEA.....GAY.....LQSLVCSVI.....LDGG.SEYR
  68 ...VARPGGFIAVRDS...D.YGAM.TWY.....PASsgmddWLDLYHRVA.....RANG.----
  69 ...ALPDNGTLVLAEA...-.MAEV.PGV.....EPI.....GDAYFGFYL.....LAMG.----
  70 ...VLKPGGSMLLHSI...L.AMFE.GKT.....N--.....---------.....----.----
  71 ...VLKPGGIFALVDL...H.RPSN.WLF.....WPP.....LAIFMGLFE.....TETA.WQLI
  72 ...LLRPGGRLVLVEG...V.WGSV.SPV.....GIP.....ADRVTALLG.....PLTG.Q---
  73 ...LLAPGGRLLLTTS...C.KGGN.VGL.....EAL.....---------.....----.----
  74 ...LAKPGGAVLNCSF...I.HPSD.FDE.....SGF.....RAWVTFLNQ.....RPWD.SEMQ
  75 ...KMKYSSYIVIESP...N.PTSL.YSL.....---.....---------.....----.----
  76 ...ILSENGVFILEE-...-.--TD.RVY.....GIM.....YLVGYKDFL.....VETK.GKDY
  77 ...LLSENGLILMDDV...F.QAGE.ILL.....PIM.....---------.....----.----
  78 ...WLKPGGYIFFRES...C.FH--.---.....---.....---------.....----.----
  79 ...AVRPGGLVVLYDA...M.IDPE.ERD.....PEV.....LLQR-----.....----.----
  80 ...VLKPSGKFIMY--...-.----.---.....---.....---------.....----.----
  81 ...ALKPGGVFI----...-.----.---.....---.....---------.....----.----
  82 ...KLSSNGTLIFS--...-.----.---.....---.....---------.....----.----
  83 ...LLRPGGCLVIYDV...F.RQPE.QNR.....QQY.....IEAYL----.....----.----
  84 ...VLTDGGIAALQAI...T.CPDA.YYD.....QYR.....SSSDFIKKY.....IFPG.GHLP
  85 ...VTRPGGVILFSTL...A.AGSL.QEL.....GDA.....WQQ------.....----.----
  86 ...VLKPGGRCLC-TY...F.LLND.ESL.....AHI.....AEGKSAHNF.....QHEG.PGYR
  87 ...VLKPHGRLIMSDP...I.A-AR.PIP.....QHL.....RQDERLRAM.....CLSG.----
  88 ...ILKPDGII-----...-.----.---.....---.....---------.....----.----
  89 ...LLNPQGVLAVQMP...D.NWLE.PTH.....---.....---------.....----.----
  90 ...VTKPGGYVCCKEA...D.LLSA.CVY.....PKE.....Y--------.....----.----
  91 ...VLRTKGRFV-AEC...G.AFGN.VSE.....VVG.....SIYSILLAL.....GATK.EQID
  92 ...VLNPGGRIVIADV...M.FESE.---.....---.....---------.....----.----
  93 ...SLKPGGSIFITTL...N.KTIP.SWF.....GGV.....LLSEYVLNL.....VPRG.THHW
  94 ...NLRKDGTIAIWGY...A.DPIF.PDY.....---.....---------.....PEFD.DLMI
  95 ...NLSTNGIAYIS--...-.----.---.....---.....---------.....----.----
  96 ...NLSTNGIAYIS--...-.----.---.....---.....---------.....----.----
  97 ...HMRPGTVLAHH--...-.----.---.....---.....---------.....----.----
  98 ...VLKPGGELYFSDI...-.-FSD.RRL.....PAS.....LLDDPVLVG.....ECLA.GALY
  99 ...LAVPGALLYVMEF...R.QLTP.SAL.....---.....---------.....----.----
 100 ...RLNPGGVFIQFQY...S.PLSE.KLL.....SRY.....FEWTRVYEV.....RNIP.PAW-
 101 ...LAVPGALLYVMEF...R.QLTP.SAL.....---.....---------.....----.----
 102 ...LAVPGALLYVMEF...R.QLTP.SAL.....---.....---------.....----.----
 103 ...-------------...-.----.---.....---.....---------.....----.----
 104 ...HLRPGGVLAVQVP...A.N---.---.....---.....---------.....----.----
 105 ...LLRPGGHLVLATV...P.L---.---.....---.....---------.....----.-DVE
 106 ...-------------...-.----.---.....---.....---------.....----.----
 107 ...RLNSGGRIVL---...-.----.---.....---.....---------.....----.----
 108 ...SLKPDGVFIASMF...G.GDTL.YEL.....---.....---------.....-RSS.LQLA
 109 1syLLKDGGELYLLSP...C.----.---.....---.....---------.....----.----
 110 ...GLQPNGTIVVKEN...N.TPTD.TDDf....---.....---------.....----.----
 111 ...HLNPNGIILPS--...-.----.---.....---.....---------.....----.----
 112 ...-------------...-.----.---.....---.....---------.....----.----
 113 ...WMKEDSLLFVHYL...-.----.---.....---.....---------.....----.----
 114 ...HLNPDGEIRLIIS...D.LAEH.LH-.....---.....---------.....----.----
 115 ...HLNPDGEIRLIIS...D.----.---.....---.....---------.....----.----
 116 ...AIQEKGVICVKEN...V.S---.---.....---.....---------.....----.----
 117 ...ELRDGTRIVTLDF...P.----.---.....---.....---------.....----.----
 118 ...MLKP---------...-.----.---.....---.....---------.....----.----
 119 ...FLRNDGTVIPQAV...F.NAAE.PVT.....---.....---------.....VNFE.NIMY
 120 ...GLKPGGVFILEGF...-.----.---.....---.....---------.....----.----
 121 ...LLETNGVLILEPQ...G.WDSY.LKA.....---.....---------.....----.----
 122 ...-------------...-.----.---.....---.....---------.....----.----
 123 ...-------------...-.----.---.....---.....---------.....----.----
 124 ...LLLPEGILVLITP...D.SQHV.GKN.....AHL.....MKNWRYSLA.....----.----
 125 ...-------------...-.----.---.....---.....---------.....----.----
 126 ...-------------...-.----.---.....---.....---------.....----.----
 127 ...-------------...-.----.---.....---.....---------.....----.----
 128 ...-------------...-.----.---.....---.....---------.....----.----
 129 ...-------------...-.----.---.....---.....---------.....----.----
 130 ...VLKAGGFLLYSTC...S.VLPD.ENE.....KVI.....EEFLSTHDK.....VEL-.----
 131 ...-------------...-.----.---.....---.....---------.....----.----


               200          210        220       230       240 
                |            |          |         |         | 
   1 ..EVS..QKRTA...LENVMRTDSIETHKVRLK.NVGFSQVELWFQCFNFGSMIAVK
   2 ..EVS..QKRTA...LENVMRTDSIETHKVRLK.NVGFSQVELWFQCFNFGSMIAVK
   3 ..EIS..QKRSM...LENVMLTDSVETHKARLH.NAGFEHSELWFQCFNFGSLVALK
   4 ..EIA..AKREA...LENVLIPYSQKENLNMLE.KAGFKKIESIFKWANFETFIAFK
   5 ..EIA..FKREA...LENVLVPYSLKENIALLE.SVGFKHVEALFKWVNFTLLVARK
   6 ..EIA..FKREA...LENVLVPYSLKENVALLE.SVGFKHVEALFKWVNFTLLVARK
   7 ..EDN..FYVRG...DGTMVYFFTEEELRGMMT.QAGLQEEQ---------------
   8 k.SLK..EYQWL...QKSAEDFPDAKTLEELFR.KAGFVAVEYQ-------------
   9 k.SLK..EYQWL...QKSAEDFPDAKTLEELFR.KAGFVAVEYQ-------------
  10 ..R-D..KVFGY...IDREDSPRPVTYQLDLLR.SVGFDAVDLLHKNSCFAAFGAVK
  11 k.SYE..EYSWL...QESAREFPGRDELAEMFR.AAGFVDVEVKPYTFGVAAM----
  12 ..SEN..FYVRG...DGTRAFYFSNEFLETLFS.EQGFEVEELDVCCK---------
  13 ..EIA..YNIEV...GDGIPQMVRKCDAVEAIK.KVGFNLLE---------------
  14 ..EIA..YNIEV...GDGIPQMVRKCDAVEAIK.KVGFNLLE---------------
  15 ..KIA..YGIEV...GDGIPKMYSRKVAEQALK.NVGFE------------------
  16 ..DAG..LYRHL...RDSVTRFDTAPAFAQRLR.RAGFADVRVL-------------
  17 ..EEN..FYVRG...DGTRVYFFSEEKLREIFT.-----------------------
  18 ..-PD..FAIYI...KKRGYDLHDVQAYGQMLR.DAGFEEV----------------
  19 ..PEA..LVRRF...NSWLER---AEDLVRTLE.GCGYA------------------
  20 ..PEA..LVRRF...NSWLER---AEDLVRTLE.GCGYA------------------
  21 ..DRT..LYRHL...RRSVVAFDTAPEFAARLT.RAGLTSVR---------------
  22 ..PEA..LVRRF...NSWLER---AEDLLRTLE.RCGYTSV----------------
  23 ..PEQ..LQQRF...NSWLAD---PRDLTRTLE.RCGFQEVT---------------
  24 ..SGN..FYVRG...DGTRVYFFTQEELDTLFT.TAGLEKVQ---------------
  25 ..GFR..EYVRS...DGTLSYFFCLDTARKLFT.DAGFIEVELEYCC----------
  26 ..--E..NMRKA...INVTVTPLTKDGWKGIFQ.ESGFRNVD---------------
  27 ..TRE..KWDG-...---------------L--.-----------------------
  28 ..DEQ..TFVRQ...DGTLSLFFREEDIAEWMK.SAGFGLVT---------------
  29 ..SGN..FYVRG...DGTRVYFFTQEELDTLFT.TAGLEKVQ---------------
  30 ..TRE..KWDG-...---------------L--.-----------------------
  31 skNKS..AYEYL...PNSIEGFLSKKEFILELK.NAGFEMLDYKSFSFGVSSMFIAK
  32 ..---..FLRES...IFPGGELPSEPDIVDNAQ.AAGFTIEHV--------------
  33 ..SEN..FYIRG...DGTRVLIVNRK-------.-----------------------
  34 ..AEF..VTDPP...SQFSFYRWSRADYESAIA.DAGFSHFEWQKPLLEAD------
  35 ..RAA..VQRYL...HDFMMTMVSAEAYPPLLR.GAGLWLEE---------------
  36 ..-AE..FAAYI...RQRGYDLHDVKAYGKMLK.DAGFVE-----------------
  37 ..PEA..LRRRF...NSWLER---PDDLEATMR.RAGFGEV----------------
  38 ..--S..EELKA...NYSKIEFKPEDFEMWLIE.TVGFESVE---------------
  39 ..P--..-----...---------VGTTVTQLE.RAGFEVRDVESIREH--------
  40 ..--S..EELKA...NYSKIEFKPEDFEMWLIE.TVGFESVE---------------
  41 g.NAG..AYTYL...PESVLAFPEPERLAQMMR.ATGFR------------------
  42 ..---..ILRES...IFPGGELPSEPDIVDNAQ.AAGFTIEHV--------------
  43 ..---..-----...----GREYTPAECVRWLS.DAGFTDVR---------------
  44 ..---..-----...-SSGIIKDRAEDVIENLK.KNKFEIIE---------------
  45 ..SGNsyAYSYL...KESIRDLPRDAALEAIFH.AAHLRPIRKRKLLFGTATIWIL-
  46 ..---..-----...-SSGIIKDRAEDVIENLK.KNKFEIIE---------------
  47 ..SGNsyAYSYL...KESIRNLPCDTSLERVFH.KSGLHIIRKRKLLFGTATIWIL-
  48 ..GIN..FYANGevcGSSKIALHSREFYEQCFK.AAGFSQIEWIAPHF---------
  49 ..---..-----...----------RKTVDNIK.KAGFVIEEEKYLLSDVVRLIIA-
  50 ..PPD..EIEQS...LNGVHYQHHIQPITLWFD.D----------------------
  51 ..PPD..EIEQS...LNGVHYQHHIQPITLWFD.D----------------------
  52 ..---..-----...------FPTAGELCTGLE.AAGMRVE----------------
  53 k.NYG..AYSYL...PQSIEGFLSLEGLKHELR.NAGFEILRTEDSIAQISTTMLVK
  54 ..AGE..GVKPG...APPLGRIGTVEAAKDLLI.QAGFAEVTAELT-----------
  55 ..SRA..YTRHV...TDKIVRNGVIGRQLARLAlDAGFAVP----------------
  56 ..T--..-----...---------PTHYHMLLS.SAGFRDFQFKKTGAIYDAILARK
  57 ..---..-----...-SSGIIKDRAEDVIENLK.KNKFEIIE---------------
  58 ..---..---SL...TGCVAGASTVDDLKAMLD.EAGFEAVEI--------------
  59 ..SLS..QFE--...--------------TLAS.DSGFLRCEIICHAFSYSVIELHK
  60 ..RLS..FARDG...DGPCWYVPDMPRLAAVGF.DDGF-------------------
  61 ..---..FIVTE...IFPGGRLPSTEMMVEHGE.KAGFTVPEPLSLRPH--------
  62 ..NWW..INRFS...TEGDVKVYQPKELTELFN.QNGWK------------------
  63 ..--E..FFEGL...NSSFVGYPGKEEVKRIIL.EEGF-------------------
  64 ..--E..FFESL...NRSFVGYPAKAEIKKAIL.REGF-------------------
  65 ..---..-----...------------------.-----------------------
  66 ..---..FIVTE...IFPGGRLPSTEMMVEHGE.KAGFTVPEPLSLRPH--------
  67 ..---..-----...---------VRDITAWAE.ETGFTVEQ---------------
  68 ..---..-----...----GEPDAGRRLKAWAL.EAGFTDITATSATWTF-------
  69 ..---..-----...---RGRPRSAARLTQMLH.EAGFASVRPLSTHMPLQAGV---
  70 ..--A..WIDKY...IFPGGYLPSLREVVSAMS.EWDFHLLLAESLR----------
  71 ..N--..-----...----------TDLGSLLD.QAGFTVVR---------------
  72 ..---..-----...------------------.-----------------------
  73 ..--N..LWFTY...ADFGGPLPQADALADQLR.QAGFDDVEA--------------
  74 ..---..-----...------------------.-----------------------
  75 ..---..INFYI...DPTHKKPVHPETLKFILE.YLGFRDVKIEFFEE---------
  76 ..TLI..SVHEG...YDPVKGVFKRTYYKLP--.-----------------------
  77 ..---..-----...------------------.-----------------------
  78 ..---..-----...------------------.-----------------------
  79 ..---..INHTM...IRDEAGAYSLQEARAYLE.EAGFT------------------
  80 ..---..-----...------F-----------.-----------------------
  81 ..---..-----...------------------.-----------------------
  82 ..---..-----...------------------.-----------------------
  83 ..---..A----...------------------.-----------------------
  84 ..SLG..AISQS...L-----------------.-----------------------
  85 ..---..-----...------------------.-----------------------
  86 ..TIH..K----...------------------.-----------------------
  87 ..---..-----...------ALTYAEYIQHLI.DTGFGQIEI--------------
  88 ..---..-----...------------------.-----------------------
  89 ..---..-----...------------------.-----------------------
  90 ..---..-----...------------------.-----------------------
  91 ..QAN..PWF--...------FGSEDDYTRMLE.EAGF-------------------
  92 ..---..-----...------------------.-----------------------
  93 ..---..-----...------------------.-----------------------
  94 ..EVP..YGKQG...LGPYWEQPGRSRLRNMLK.D----------------------
  95 ..---..-----...------------------.-----------------------
  96 ..---..-----...------------------.-----------------------
  97 ..---..-----...------------------.-----------------------
  98 ..T--..-----...----------EDFRRAL-.-----------------------
  99 ..---..-----...------------------.-----------------------
 100 ..---..-----...------------------.-----------------------
 101 ..---..-----...------------------.-----------------------
 102 ..---..-----...------------------.-----------------------
 103 ..---..-----...------------------.-----------------------
 104 ..---..-----...------------------.-----------------------
 105 ..GVD..ATFMG...QPVRVTSFPAQELIALAE.EAGLEV-----------------
 106 ..---..-----...------------------.-----------------------
 107 ..---..-----...--NAVTIENLAEAMKAFK.ERGFE------------------
 108 ..ELE..RKGGI...SPHISPFTQIRDIGSLLN.RAGFTML----------------
 109 ..---..-----...------------------.-----------------------
 110 ..---..--DE-...-TDSSVTRSDAKFRQIFE.EAGLK------------------
 111 ..---..-----...------------------.-----------------------
 112 ..---..-----...------------------.-----------------------
 113 ..---..-----...------------------.-----------------------
 114 ..---..-----...------LRPSDFLDKAFA.QAG--------------------
 115 ..---..-----...------------------.-----------------------
 116 ..---..-----...------------------.-----------------------
 117 ..---..-----...------------------.-----------------------
 118 ..---..-----...------------------.-----------------------
 119 ..DEN..LSQPS...SGPMRVYDRVE-------.-----------------------
 120 ..---..-----...------------------.-----------------------
 121 ..---..-----...------------------.-----------------------
 122 ..---..-----...------------------.-----------------------
 123 ..---..-----...------------------.-----------------------
 124 ..---..-----...------------------.-----------------------
 125 ..---..-----...------------------.-----------------------
 126 ..---..-----...------------------.-----------------------
 127 ..---..-----...------------------.-----------------------
 128 ..---..-----...------------------.-----------------------
 129 ..---..-----...------------------.-----------------------
 130 ..---..-----...------------------.-----------------------
 131 ..---..-----...------------------.-----------------------