; SAM: prettyalign v3.1b (February 24, 1999) compiled 04/18/00_11:44:15 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ------ Citations (HMMs, SAM) ------ ; A. Krogh et al., Hidden Markov models in computational biology: ; ------------- Citations (SAM, SAM-T99, HMMs) ----------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; -------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 T0092 ; 2 gi|1175220|sp|P43985|YECO_HAEIN_1:241 ; 3 gi|3025151|sp|P76290|YECO_ECOLI_3:242 ; 4 gi|6968057|emb|CAB75226.1|_1:235 ; 5 gi|7449893|pir||F71861_2:242 ; 6 gi|7449894|pir||D64568_2:242 ; 7 gi|7292119|gb|AAF47531.1|_5:216 ; 8 gi|1346175|sp|P49016|GRCB_LACLA_37:225 ; 9 gi|538899|pir||B48653_37:225 ; 10 gi|7470360|pir||S74478_16:256 ; 11 gi|7674095|sp|O86169|MENH_BACST_28:228 ; 12 gi|3075397|gb|AAC14529.1|_47:258 ; 13 gi|7443714|pir||T42375_45:224 ; 14 gi|6166151|sp|O14321|ERG6_SCHPO_99:278 ; 15 gi|6015114|sp|O74198|ERG6_CANAL_97:273 ; 16 gi|1632838|emb|CAA64854.1|_16:217 ; 17 gi|6324814|ref|NP_014883.1|_119:324 ; 18 gi|6692724|gb|AAF24830.1|AC012679_1_56:230 ; 19 gi|516113|gb|AAA87622.1|_6:184 ; 20 gi|530212|gb|AAB16936.1|_30:210 ; 21 gi|7481052|pir||T37021_15:216 ; 22 gi|532249|gb|AAA65210.1|_31:212 ; 23 gi|7800670|gb|AAF70111.1|AF257324_12_32:213 ; 24 gi|7023954|dbj|BAA92136.1|_116:278 ; 25 gi|3776564|gb|AAC64881.1|_55:298 ; 26 gi|2495672|sp|Q57060|Y095_HAEIN_1:189 ; 27 gi|729153|sp|Q06528|CM4T_STRPE_142:321 ; 28 gi|7490350|pir||T40404_15:219 ; 29 gi|6841182|gb|AAF28944.1|AF161384_1_179:341 ; 30 gi|530214|gb|AAB16938.1|_142:321 ; 31 gi|6967798|emb|CAB72791.1|_37:233 ; 32 gi|7478388|pir||B70614_47:224 ; 33 gi|7106072|emb|CAB76043.1|_69:265 ; 34 gi|7328463|dbj|BAA92862.1|_11:218 ; 35 gi|4731342|gb|AAD28459.1|AF127374_14_30:221 ; 36 gi|7407189|gb|AAF61950.1|AF237633_1_249:428 ; 37 gi|2916809|emb|CAA12014.1|_31:212 ; 38 gi|7509433|pir||T26512_115:346 ; 39 gi|7672273|emb|CAB89463.1|_189:360 ; 40 gi|7509432|pir||T26511_112:343 ; 41 gi|7474059|pir||F75277_46:222 ; 42 gi|1575546|gb|AAC44616.1|_47:224 ; 43 gi|730914|sp|P39896|TCMO_STRGA_161:322 ; 44 gi|1723586|sp|P45558|PRMA_CLOAB_129:297 ; 45 gi|7445290|pir||D71516_16:227 ; 46 gi|541428|pir||S41759_129:297 ; 47 gi|7190742|gb|AAF39525.1|_27:237 ; 48 gi|7496359|pir||T33131_11:222 ; 49 gi|7462981|pir||E72392_6:199 ; 50 gi|2506982|sp|P12999|BIOC_ECOLI_27:193 ; 51 gi|145427|gb|AAA23517.1|_27:193 ; 52 gi|7471558|pir||E75511_1:180 ; 53 gi|7429749|pir||C64705_47:244 ; 54 gi|7473566|pir||C75569_31:199 ; 55 gi|141450|sp|P20187|YT37_STRFR_101:279 ; 56 gi|1170276|sp|P46597|HIOM_HUMAN_184:345 ; 57 gi|4104516|gb|AAD02056.1|_63:230 ; 58 gi|7484088|pir||T08338_198:354 ; 59 gi|6598836|gb|AAF18691.1|AC010795_6_178:381 ; 60 gi|1890588|emb|CAB01936.1|_58:240 ; 61 gi|1575549|gb|AAC44619.1|_62:240 ; 62 gi|2281316|gb|AAC45501.1|_11:188 ; 63 gi|7518112|pir||D75063_134:303 ; 64 gi|7518704|pir||E71168_137:306 ; 65 gi|7521702|pir||C75210_6:141 ; 66 gi|1825535|gb|AAC44876.1|_59:237 ; 67 gi|5902658|gb|AAD55585.1|_154:326 ; 68 gi|7479391|pir||T34740_28:205 ; 69 gi|7416784|dbj|BAA94033.1|_197:383 ; 70 gi|6968616|emb|CAB73437.1|_139:314 ; 71 gi|6136578|sp|Q55423|Y829_SYNY3_31:191 ; 72 gi|7480087|pir||T36753_20:176 ; 73 gi|7481048|pir||T34921_173:340 ; 74 gi|7688721|gb|AAF67508.1|AF170880_15_8:175 ; 75 gi|7483336|pir||F69255_255:427 ; 76 gi|7517797|pir||A75217_4:200 ; 77 gi|1771204|emb|CAA68045.1|_12:184 ; 78 gi|7407189|gb|AAF61950.1|AF237633_1_16:165 ; 79 gi|1076062|pir||JC4099_89:270 ; 80 gi|7518537|pir||C71246_6:142 ; 81 gi|7519075|pir||A71001_10:142 ; 82 gi|1175329|sp|P44074|Y912_HAEIN_8:150 ; 83 gi|7470235|pir||S74397_19:177 ; 84 gi|7511552|pir||T18571_301:458 ; 85 gi|543890|sp|P36571|BIOC_SERMA_30:159 ; 86 gi|2829568|sp|P71779|YE98_MYCTU_2:151 ; 87 gi|7469840|pir||S76978_57:219 ; 88 gi|7470129|pir||S77194_37:159 ; 89 gi|6094425|sp|P76145|TAM_ECOLI_16:139 ; 90 gi|7490910|pir||T38024_23:164 ; 91 gi|7491966|pir||T41554_22:187 ; 92 gi|7445263|pir||C75155_13:143 ; 93 gi|7298756|gb|AAF53967.1|_38:173 ; 94 gi|6321023|ref|NP_011102.1|_25:193 ; 95 gi|2073517|emb|CAA72463.1|_64:177 ; 96 gi|6226396|sp|O05979|Y789_RICPR_64:177 ; 97 gi|7495376|pir||T33771_54:216 ; 98 gi|6491814|emb|CAB61860.1|_72:225 ; 99 gi|7467445|pir||T17439_1162:1298 ; 100 gi|3758823|emb|CAA09857.1|_37:184 ; 101 gi|408802|gb|AAA27636.1|_1156:1292 ; 102 gi|1346305|sp|P48633|HMP2_YEREN_1156:1292 ; 103 gi|7416806|dbj|BAA94055.1|_44:153 ; 104 gi|7471497|pir||D75520_17:131 ; 105 gi|6434718|emb|CAB61165.1|_43:197 ; 106 gi|7496331|pir||T33109_13:128 ; 107 gi|3724043|emb|CAA04312.1|_202:363 ; 108 gi|7303243|gb|AAF58305.1|_66:222 ; 109 gi|7514524|pir||D70359_31:166 ; 110 gi|6319738|ref|NP_009820.1|_42:205 ; 111 gi|7299975|gb|AAF55147.1|_235:348 ; 112 gi|2128868|pir||C64481_13:122 ; 113 gi|7486450|pir||T05192_50:168 ; 114 gi|7380059|emb|CAB84640.1|_140:291 ; 115 gi|7226471|gb|AAF41613.1|_115:245 ; 116 gi|3183316|sp|O13748|YDRE_SCHPO_45:162 ; 117 gi|7516544|pir||H72630_34:150 ; 118 gi|6015918|emb|CAB57745.1|_17:113 ; 119 gi|7451049|pir||F69198_18:167 ; 120 gi|7469807|pir||S76919_21:132 ; 121 gi|7491567|pir||T40101_33:198 ; 122 gi|2121206|pir||I76774_47:152 ; 123 gi|3088592|gb|AAC14722.1|_48:142 ; 124 gi|7291819|gb|AAF47239.1|_119:250 ; 125 gi|2495889|sp|Q57732|Y284_METJA_9:108 ; 126 gi|1169553|sp|P45438|ERMK_BACLI_27:114 ; 127 gi|477038|pir||A47697_27:114 ; 128 gi|1169552|sp|Q03986|ERMD_BACLI_27:114 ; 129 gi|730032|sp|Q04720|ERMJ_BACAN_27:114 ; 130 gi|2126366|pir||I40649_65:229 ; 131 gi|7433474|pir||F69472_15:96 10 20 30 40 50 | | | | | 1 MVKDTLFSTPIAKLGDF...IFDENVAEVFPDMIQRSVPGYSNIITAIGMLAE.RFVTAD.SN.. 2 MVKDTLFSTPIAKLGDF...IFDENVAEVFPDMIQRSVPGYSNIITAIGMLAE.RFVTAD.SN.. 3 -HRDTLFSAPIARLGDW...TFDERVAEVFPDMIQRSVPGYSNIISMIGMLAE.RFVQPG.TQ.. 4 MMKDELFKQSPKK--QF...EFDKSVASVFDDMINRSVPFYRENLELCGNLLA.KILPTN.AS.. 5 --KDTLFNESLNK--RF...CFDEKVAHVFDDMLERSIPYYHEMLNLGAYFIA.QNLKEN.VYhk 6 --KDTLFNESLNK--RF...CFDEKVAHVFDDMLERSIPYYHEMLNLGAYFIA.QNLKEN.IYpk 7 --QKERFQTDAPKFWDS...FYGIHDNRFFKD----RHWLFTEFPELAPLAAD.SAVLQP.RS.. 8 -----------------...--------------------QHDLWRAKTMKRM.GDLT-G.LS.. 9 -----------------...--------------------QHDLWRAKTMKRM.GDLT-G.LS.. 10 -MTTPLEKKSTIEDIRS...RFDKDVARFSSLETGQATTIDAPLAMSLITEAA.ISCTKNiRH.. 11 -----------------...------------------SFRRHLKWRKDVMRR.MNVQKG.KK.. 12 -TNTDKYERDAKKYWDI...FYKHHGDRFFKD----------RHYLDKEWNSY.FSVSGK.SV.. 13 FYKGEAFAQSIARHEHY...-----------------------------LAYR.MGIKPG.SR.. 14 FYKGEAFAQSIARHEHY...-----------------------------LAYR.MGIKPG.SR.. 15 YYKGEAFRQATARHEHF...-----------------------------LAHK.MNLNEN.MK.. 16 -----------------...-----GSTAYDRLVSASPGYHAHLRRSARRLGL.PEEGRG.LR.. 17 EFDKKLYNENPARYWDI...FYKNNKENFFKD------RKWLQIEFPILYAST.RKDAEP.VT.. 18 -----------------...-------LRYERVFGEGFVSTGGLETTKEFVDM.LDLKPG.QK.. 19 -----------------...-------------------------MGRRLVDI.SEPVTG.ER.. 20 -----------------...-----------------------TPMGRRLVDI.SEPVTG.ER.. 21 -----------------...----HASHTYDGLTALNPGYRTGLLRSARRLAL.PADGAG.LH.. 22 -----------------...------------------------PMGRPLVEI.SEPVTG.ER.. 23 -----------------...-------------------------MGRRLVER.AAPAAG.AR.. 24 -----------------...---------------------------------.-----T.YR.. 25 -HSRHSSGKFFKVLHTH...HYSISCNQLLSFTIEEKFELVERRYLLKEFPEL.VSCGEN.SK.. 26 MAKDEVGHNFLARLGKT...RLRPGGKKATDW-----------------LIAN.GGFSQD.KK.. 27 FYEDLAGRPDLRASFDS...LLACDQDVAFDA-----------------PAAA.YDWTNV.RH.. 28 ------YKKESKKSWDK...FYKRNETRFFKD----RHWLDREFDCYFGLPDK.L----P.LT.. 29 -----------------...---------------------------------.-----T.YR.. 30 FYEDLAGRPDLRASFDS...LLACDQDVAFDA-----------------PAAA.HDWTNV.RH.. 31 -----------------...--------------------------ACQRVMS.LYLKKD.LK.. 32 -----------------...---------------------AQLAKVDLALDK.LNLEPG.MT.. 33 VTEKDAYMTHPERYWDQ...FYGKNEGKFFMN----RRWIAQEFPELLDLLKE.--DAGE.KS.. 34 -----------------...----------GGLFEDFTQSAAQAIEVRTIFHM.IGDVSG.KS.. 35 --------------GAA...SLGENLHFGYWDSPDSQVPLAEATDRLTDMMAErLRIGAG.SR.. 36 -----------------...-YKFNSILRYERVFGPGYVSTGGLETTKEFVSK.LDLKPG.QK.. 37 -----------------...------------------------PMGLRLVDH.ADPRPG.QR.. 38 YFNKKYRYGNFDRYYGI...RLNPGESDKRLS------------------VFQ.KDWFEH.KQ.. 39 -----------------...-------------------------KLELVSRK.LDLSPG.RR.. 40 YFNKKYRYGNFDRYYGI...RLNPGESDKRLS------------------VFQ.KDWFEH.KQ.. 41 -----------------...----------RR----------------AAAAE.ALAHSP.RR.. 42 -----------------...---------------------AQLAKVDLALDK.LNLEPG.MT.. 43 -----------------...-----------------------------LAGA.LDWTEY.SS.. 44 IVVKPLWEEYTPKDYEL...MLNMDPGMAFGT-------GTHETTRMCIQALE.RYVNED.AE.. 45 -----------------...-------SLAPTYDKINGILSLGLHIAWNNALV.SLLGET.NH.. 46 IVVKPLWEEYTPKDYEL...MLNMDPGMAFGT-------GTHETTRMCIQALE.RYVNED.AE.. 47 -----------------...--------LAPTYDKINKILSLGLHLTWNHSFV.SLLGRS.DH.. 48 -----------------...------------EAQQKWLGRDHLITPTIKKAF.GHILVG.KE.. 49 --KYDRFAALYDKFESF...IEKKFFSRFREELFKR-----------------.---VEG.KK.. 50 -----------------...----------------------QRQSADALLAM.LPQRKY.TH.. 51 -----------------...----------------------QRQSADALLAM.LPQRKY.TH.. 52 MMTDAWNAEQYRDRHAF...VFQSSEDLAAEW---------------------.LRPQPG.ER.. 53 -----------------...------------------------------FLF.LENKKA.LR.. 54 -----------------...-------------------------AALALAAA.LDVPPT.GR.. 55 -YLDQLATTDAARSYKS...V----------------------------MLDA.LDARPG.ES.. 56 -----------------...---------------------------------.------.--.. 57 -VVKPLWEEYTPKDYEL...MLNMDPGMAFGT-------GTHETTRMCIQALE.RYVNED.AE.. 58 -----------------...---------FAA---------------------.--MAPG.ET.. 59 ---------------RF...FELIGSNEQFAEMFNRAMSEASTLIMKKVLEVY.KGFEDV.NT.. 60 -----------------...-------------------------FLGHFILL.GGVRPE.SR.. 61 -----------------...--------------------------VDLNLDK.LDLKPG.MT.. 62 -RESENFYDRIASQFDH...SFDGFLASFFKR----------------FILKN.LKFEQN.SK.. 63 ------------DFWDL...RLSSSFNKIYRD----------------VIVNL.GEINRE.SY.. 64 ------------DFWDI...RLSSSFNKTYRD----------------AIINL.GEIRED.SY.. 65 -----------------...-----YYRAFPTYTDINSQEYRDRLENLEPLLM.KYMKRR.GK.. 66 -----------------...--------------------------VDLNLDK.LDLKPG.MT.. 67 -----------------...----------------DHMDTFNQFVVAELSKA.LDWSRW.KT.. 68 -----------------...---EN----------------------SAAYLL.GSLRPH.MR.. 69 -----------------...----------------KLMTASQPLVAREVIAA.YRFGRH.KV.. 70 --NNTLYEAQINKIEH-...-----------------------------TLKK.LDLKEG.EK.. 71 -----------------...-------ERFHQ----------------LPLEN.LAISPG.QK.. 72 -----------------...-------ASFDDEPDHGLRDAEVRRAWAARLAS.WLPAPP.GD.. 73 -----------------...---------------------QPLVEEA-IART.LDRNAP.VR.. 74 -----------------...---GSEAEAFHRMGSQASHRYDEFVDLLVGAGI.A---DG.QT.. 75 -----------------...----------YFLFEEKFRGSRELVKARLRRYI.PYFKGC.RR.. 76 --------EELYKYLRW...RMDPEDKRAVER--------FHRIVEVFEKLKD.SKLISG.SR.. 77 MMNRPVVKAELVEWMRSsqtQVTGELAEVLNFAKENNIPVIPHETVLY-FQML.LSLLKP.KR.. 78 --------------KKY...WIEHSVDLTVEAMMLDSQASDLDKVERPEVLSM.LPPYEG.KS.. 79 -------YEDLDRARQI...MLH---------------MDAHNGFTADELARA.IDWSRY.TS.. 80 -----------------...-----YYRVFPTYTDINSQEYRSRIETLEPLLM.KYMKKR.GK.. 81 ------------EYYDT...IYRRRIERV-----------KAEIDFVEEIFKE.DAKREV.RR.. 82 -YDKDNFFELYQKLRA-...----------------NPISLNEIIEKPTMLSL.LPNLKG.KK.. 83 -----------------...-------QTYQQLVDHNYMAHRQIHQAVGALIQ.QQFDRP.FD.. 84 ------QYKKIDR----...-----------------------------LIDQ.LELKAD.DH.. 85 -----------------...---------------------LQRDVGERLLGM.GSSHPG.EQ.. 86 -----------------...---------------------------------.------.--.. 87 -----------------...---------------------------------.--LGNK.SK.. 88 LYEGSLVTARYRRDGKV...IT-------------------------------.--DLEN.RV.. 89 -----------------...----------------------RSRPAVELLAR.VPLENV.EY.. 90 -----------------...--------------------AWRTPETCSTYML.KYVKKT.DR.. 91 -----------------...--------------------------TKDIVKR.INLSSS.DE.. 92 -----------------...-------RTYDEDVEREDWIHADYEEVLKLVAE.RV---G.GT.. 93 -----------------...---------------------------------.-----G.QN.. 94 -----------------...--------------------------FYKMIDE.YHDGER.KL.. 95 -----------------...------------------------------GIN.APEVEN.SK.. 96 -----------------...------------------------------GIN.APEVEN.SK.. 97 LYEDDDVEELVERDELS...RTYCPVCSSRDTVPLNFISHSLSRLQVKFLFDL.LMPPTC.QH.. 98 -----------------...--------------------------------I.PPALEG.AT.. 99 -----------------...---------------ASAPYIQELATICQQLAQ.R-LQRP.VR.. 100 -----------------...---------------------SSPWLCNRMAGL.ADWTQA.TT.. 101 -----------------...---------------ASAPYIQELATICQQLAQ.R-LQRP.VR.. 102 -----------------...---------------ASAPYIQELATICQQLAQ.R-LQRP.VR.. 103 -----------------...--------------------GRDRMRTTLLSWL.PQDLRG.RR.. 104 -----------------...------------------------APARDLQAL.IPERPY.AQ.. 105 -----------------...----------------------KTHRRSLEWLL.ARLAPG.SR.. 106 -----------------...-------------AQQKWLYQDHLVLPTLEKLL.KYNLKD.KK.. 107 -----------EESPVW...PLGIEDDEFIQRKPDKGLITKKEIRTL--SISA.LQLKRD.SV.. 108 ------------RVFDI...---------------------------------.--KREF.KA.. 109 -----------------...-------------------------LVLFLSKI.KPPKRN.YR.. 110 -----------------...----------------DVLGSNNFLRKLKSRML.PQENNV.KY.. 111 -----------------...-----------------------------LLQN.EAVVRG.KT.. 112 -----------------...----------------SLLTDYERLAIFKNAIE.RVVDED.DV.. 113 -----------------...------------------------AMLALSCER.AKVEDG.QS.. 114 -----------------...-------------------------EYLDLLAH.APSTGF.QT.. 115 -----------------...-------------------------EYLDLLAH.APSTGF.QT.. 116 -----------------...--------------------------LNRLNYR.IGKIEN.LV.. 117 -----------------...------------------------ELIPKILEL.LDLKED.DV.. 118 -----------------...--------------------------VRRMLEI.AKASQD.DI.. 119 -----------------...-----------------------RLAA--FREA.ISSRAR.GL.. 120 -----------------...-----------------------------LVSV.ANQIPQ.GK.. 121 -----------------...---------------------------------.--LFYE.AS.. 122 -----------------...-------------------------------LS.RALGRP.LN.. 123 -----------------...-------------------------------GR.KPSTDN.IR.. 124 -----------------...--------------------------------M.EEPPDR.LH.. 125 MMLDSLKRHPNPKADLE...QYTIDGKLAADI-----------------LFFA.VNDFYN.NV.. 126 MHNKKLIEEIVDRANIS...I--------------------------------.-----D.DT.. 127 MHNKKLIEEIVDRANIS...I--------------------------------.-----D.DT.. 128 MHNKKLIEEIVDRANIS...I--------------------------------.-----D.DT.. 129 MHNKKLIEEIVDRANIS...I--------------------------------.-----D.DT.. 130 -----------------...-----------------------------AAYL.LKLENN.QT.. 131 -----------------...-----------------------RRVISRIVGY.AELSED.DV.. 60 70 80 90 100 | | | | | 1 ......VYDLGCSRGAATLSARR...NINQPNVKIIGIDNSQPMVERCRQHI.......AAYH.S 2 ......VYDLGCSRGAATLSARR...NINQPNVKIIGIDNSQPMVERCRQHI.......AAYH.S 3 ......VYDLGCSLGAATLSVRR...NIHHDNCKIIAIDNSPAMIERCRRHI.......DAYK.A 4 ......VCDLGCSSANFLIFLAN...LR--KDFKLFGVDNSASMLEVAKSKA.......KAYG.L 5 slpkplIYDLGCSTGNFFIALNQ...QIQ-QDIELVGIDNSMPMLKKAQEKL.......KDFN.- 6 slpkplIYDLGCSTGNFFIALNR...QIQ-QEIELVGIDNSMPMLKKAQEKL.......KDFN.- 7 ......IFELGCGVGNTILPLLQ...YSSEPQLKVFGCDFSARAIEILRSQR.......QFDE.K 8 ......ILDLCCGTGDWTFDLSE...SVG-PSGKVIGLDFSENMLEIAKAKL.......KEEA.K 9 ......ILDLCCGTGDWTFDLSE...SVG-PSGKVIGLDFSENMLEIAKAKL.......KEEA.K 10 ......VLDIGCGAGNNTLRLRQ...SAN-YDFNVDLLDLSAPMLMKAAERV.......QQLN.R 11 ......ALDVCCGTADWTIALAE...AVG-PEGKVYGLDFSENMLKVGEQKV.......KARG.L 12 ......ILEVGCGAGNTIFPLIA...TY--PDIFVYACDFSPRAVELVKAHD.......EYTE.T 13 ......VLDVGCGVGGPAREITE...FT---GCNLVGLNNNDYQISRCNNYA.......VKRN.L 14 ......VLDVGCGVGGPAREITE...FT---GCNLVGLNNNDYQISRCNNYA.......VKRN.L 15 ......VLDVGCGVGGPGREITR...FT---DCEIVGLNNNDYQIERANHYA.......KKYH.L 16 ......VLDLGCGTGASTAALLA...AA--PRARITGVDASAGMLDRATAKS.......WPQG.- 17 ......IFEIGCGAGNTFFPILK...DNENENLRIIAADFAPRAVELVKNSE.......QFNP.K 18 ......VLDVGCGIGGGDFYMAE...NF---DVDVVGIDLSVNMISFALEH-.......-AIG.L 19 ......VLDIGCGRGACLFPAAE...KVG-SQGCVHGIDIAPGMIEEARKEA.......TERG.L 20 ......VLDIGCGRGACLFPAAE...KVG-SQGCVHGIDIAPGMIEEARKEA.......TERG.L 21 ......LLDLGCGTGASTRALLR...AA--PRARITAVDASAGMLRRALVK-.......-PWP.A 22 ......VLDIGCGRGACLFPAAE...KVG-PQGRVHGIDIAPGMIEEARKEA.......AERG.L 23 ......VLDVGCGRGACVFPAAE...RVG-PEGRVVGIDVAEAMIEEATKEA.......ALRD.A 24 ......ILEVGCGVGNTVFPILQ...TNNDPGLFVYCCDFSSTAIELVQTNS.......EYDP.S 25 ......LLEIGCGNGSTVLPILR...GS--KNITVYACDCSSDALVRTKENId......RAIS.S 26 ......VLEVACNMGTTAIGLAK...QF---GCHIEGVDLDENALAKAQANI.......EANG.L 27 ......VLDVGGGKGGFAAAIAR...RA--PHVSATVLEM-AGTVDTARSYL.......KDEG.L 28 ......ILEVGCGVGNLVYPLLE...VQ--PNLKIYCCDFSPRAIDFVKKHS.......CYNE.N 29 ......ILEVGCGVGNTVFPILQ...TNNDPGLFVYCCDFSSTAIELVQTNS.......EYDP.S 30 ......VLDVGGGKGGFAAAIAR...RA--PHVSATVLEM-AGTVDTARSYL.......RDAG.L 31 ......IADIACGTGDMIEIWQEsalKMEKNILNIKGIDPSSGMLNVAKEKF.......P---.- 32 ......LLDVGCGWGGALVRAVE...KY---DVNVIGLTLSRNHYERSKDRL.......AAIG.T 33 ......ILEIGCGAGNTIWPILK...ENKNSNLKIFAVDYSEKAIDVVKQNP.......LY-D.A 34 ......VLDLACGFGFFGREIYR...R---GAAKVVGVDISEKMIELAREES.......RKYG.D 35 ......VLDLGCGVGTPGVRIAR...L---SGAHVTGISVSHEQVVRANALA.......EEAG.L 36 ......VLDVGCGIGGGDFYMAE...NY---DVEVVGIDLSINMISFALER-.......-SIG.L 37 ......VLDVGCGRGACLFPAAR...RVA-PDGYALGIDIAPAMVEEAAAEA.......ERLG.M 38 ......ALDIGCNAGFLTLSIAK...DF--SPRRIIGIDIDEHLIGVARKNI.......RHYC.- 39 ......LLDVGCGWGSMAIHAAR...EH---GVSVVGVTLSQEQAAYARKRV.......ADEG.L 40 ......ALDIGCNAGFLTLSIAK...DF--SPRRIIGIDIDEHLIGVARKNI.......RHYC.- 41 ......VLDVATGTGDFAIELKE...RA--PQVEIVGSDFVPQMLDLARQKA.......GAKQ.L 42 ......LLDVGCGWGGALVRAVE...KY---DVNVIGLTLSRNHYERSKDRL.......AAIG.T 43 ......FVDLGGARGNLAAHLHR...AH--PHLRATCFDL-PEMEPFFQEHM.......KSLE.T 44 ......VFDIGTGSGILAIAAAK...L---NAKKVLGVDLDSVAVKAAKENI.......QYNN.V 45 ......LLDLCAGTGRVALSYVQ...NY--PRASATLVDFSTKMLENVQKRH.......PSAP.- 46 ......VFDIGTGSGILAIAAAK...L---NAKKVLGVDLDSVAVKAAKENI.......QYNN.V 47 ......LLDLCAGTGHVALSYIQ...KY--PQASATLVDFSTKMLENVQECH.......PLAP.- 48 ......VLDVGCGNGHYSFDFLR...W---GAHKVFGVDNSEEMIQICKSSP.......DFEN.F 49 ......ILEVGIGTGKNVPYYS-...----DDMDVVGVDISEGMLRVCQERL.......KKFP.E 50 ......VLDAGCGPGWMSRHWRE...R----HAQVTALDLSPPMLVQARQKD.......AADH.- 51 ......VLDAGCGPGWMSRHWRE...R----HAQVTALDLSPPMLVQARQKD.......AADH.- 52 ......ILDLGCGSGELTARIAQ...S----GAQVVGVDASPAMIAAAQSSF.......P---.- 53 ......LVDVACGTGDMLVAWQKsalNCGIEFKECLGIDPSNNMLELAIKKC.......EELE.N 54 ......VLDVATGTGTVALTLAP...K----VAEVMGTDIAPAMIEQARQRA.......AGRS.- 55 ......ALDLGCGPGTDLGTLAK...AVS-PSGRVIGIDSSQEMVEQARRRT.......ENLP.- 56 ......-CDLGGGAGALAKECMS...LY--PGCKITVFDI-PEVVWTAKQHF.......SFQE.E 57 ......VFDIGTGSGILAIAAAK...L---NAKKVLGVDLDSVAVKAAKENI.......QYNN.V 58 ......VLDLGSGAGFDCFLAAQ...EVG-PDGHVIGVDMTPEMISKARENV.......AKND.A 59 ......LVDVGGGIGTIIGQVTS...KY--PHIKGINFDL--------ASVL.......AHAP.F 60 ......VLDIGCGIGRMAVPLTQ...YLDFEKGHYSGIDPVEGGIGWCRRFI.......TSVY.P 61 ......LLDIGCGWGTTMRRAVE...RF---DVNVIGLTLSKNQLARCEQVL.......ASID.T 62 ......ILDIGCANGKLLAMLND...K---KKIVGSGLDISSEMIKVAKAQY.......P---.- 63 ......VLDLGCGSVSPSYFGKF...IS--EDGKYLGVDYSPGLLEIARQRV.......EREG.L 64 ......ILDLGCGSVSPAYFGKF...IS--EDGKYVGVDYSPGLLEIARERV.......ERNG.L 65 ......VLDLACGVGGFSFLLED...Y----GFEVVGLDISEEMISKAKMYA.......KEKS.S 66 ......LLDIGCGWGTTMRRAVE...RL---DVNVIGLTLSKNQHARCEQVL.......ASID.T 67 ......FVDVGGARGNVAAQLVL...DH--PDLKGSVFDV-PGVEPLFDEHM.......AARG.T 68 ......ILDIGCGPGTITADLAE...RV--PEGHVTGVDRSPEIVERARATA.......AARG.L 69 ......LMDVGGGEGAFVRCVAA...EV--PGVELRVFDL-PAVAERANENF.......QRWG.L 70 ......LLDIGCGWGWLSIMAAQ...KY---GVKVVGITISEEQCKKAKERV.......KELG.L 71 ......VLDLCCGGGQATVYLAQ...S----GATVVGLDASPKALGRAKINV.......P---.- 72 ......VLDLGCGTGSLSLLAAE...Q----GHRVTGVDLSPAMVELARTKL.......AGRD.- 73 ......LLEVGCGSGTYVRYAAE...LN--PRLSALAVDLQQDVADSAAANM.......AEWG.L 74 ......VVDLCCGSGELEVILSS...RF--PSLNLVGVDLSEDMVRIAREYA.......AEQG.K 75 ......VLDIGCGRGEFLELCKE...E----GIESIGVDINEDMIKFCEGKF.......NVVK.S 76 ......VLDICAGTGIAGVALAK...VL--NAKKLTVLDVRREDLDKVEKWM.......EVAG.I 77 ......ILEIGTAIGFSALVMAQ...EV--PEAEIVTIDRNPEMIELAKKNL.......AKYD.H 78 ......VLELGAGIGRFTGELAE...K----ASQVIALDFIESVIKKNESIN.......GHYK.- 79 ......FVDVGGGRGNVASRIVT...AH--PHLRGGVFDL-PALRPLFEELV.......ASAG.T 80 ......VLDLACGVGGFSFLLED...Y----GFEVVGVDISEDMIRKAREYA.......KSRE.S 81 ......VLDLACGTGIPTLELAE...R----GYEVVGLDLHEEMLRVARRKA.......KERN.L 82 ......LLDLGCGTGGHLQLYLE...R---GAAKVIGTDLSEKMLEQAEKDL.......QKCGqF 83 ......FLDLGCGDAQAIAKTLT...GS--KINSYTGVDLSPNALALAQKNL.......DPFR.- 84 ......VLEIGCGWGAAAIRAVQ...R---SGCKWTGITISKEQLEWGQKKV.......VEAG.L 85 ......LLDAGCGTGYFSRMWRE...R----GKRVTALDLAPGMLDVARQRQ.......A---.- 86 ......-LDVGCGSGRMALPLTG...YLN-SEGRYAGFDISQKAIAWCQEHI.......TSAH.P 87 ......VLYVGVGGGLEALQFAY...FCR-QPGAVIAVDPVEAMRQAAQRNLqlaaeknDWFS.V 88 ......MLDVACGTGATTLTMAL...AN--PGAKVVGIDISPESIKIAEERL.......QYHK.I 89 ......VADLGCGPGNSTALLQQ...RW--PAARITGIDSSPAMIAEARSAL.......P---.- 90 ......ILDVGCGPGTITVGFPK...YV--PEGEVIGVEPSQELLDKAEEALrkeetl.KKEK.I 91 ......LLDLGCGDGVLTNELVS...Q----CRRVVGIDASPDMIKAAREL-.......-GLN.A 92 ......VVDIGCGTGNILCFL--...----KCERYIGVEPSRGMRAKFKEKH.......GFEP.L 93 ......ILEVGCGGGLLTEHLAR...L----GAQVAGIDLGEKLIEAAREHL.......KCSS.P 94 ......LVDVGCGPGTATLQMAQ...ELK-PFEQIIGSDLSATMIKTAEVIK.......EGSP.D 95 ......ILELGCAAGGNLIPHAV...LY--PNAHFVGVDLSKVQIDEANKNV.......RALG.L 96 ......ILELGCAAGGNLIPHAV...LY--PNAHFVGVDLSKVQIDEANKNV.......RALG.L 97 ......VLDIGSRLGAIVYGASI...FTN-GNVSTIGVEMDSDYAALALRTI.......RQFG.L 98 ......VLDLGSGSGRDVYVLSQ...LVG-PTGRVIGVDMTEEQLAVARRHQdwha...ERFG.H 99 ......LLEVGTRTGRAAESLLA...QLNAGQIEYVGLEQSQEMLLSARQRL.......APWP.G 100 ......VAELGAGDGVLTRRLLD...RMA-PDTQLDAWEIQPELVGQLRSLA.......EHDH.- 101 ......LLEVGTRTGRAAESLLA...QLNAGQIEYVGLEQSQEMLLSARQRL.......ASWP.G 102 ......LLEVGTRTGRAAESLLA...QLNAGQIEYVGLEQSQEMLLSARQRL.......ASWP.G 103 ......VLDAGCGTGAASIELAR...R----GAEVVAIDLSPTLVGYARERL.......PESL.G 104 ......VVDLGCGTGEQTAQLAQ...RF--PQATVLGLDSSAAMLAKAGAQ-.......-QLP.- 105 ......VLDVGSGTGRPTAETLA...GA---GHEVLGVDVSPVMVELAARQV.......P---.- 106 ......VLDIGCGNGLNSTTFLQ...W---GARKVVGFDNSQEMIENCKNLH.......KSSE.- 107 ......VWDIGTCTGSVAIEAAK...IA--REGQIFAVEKNEADLENCRENL.......AKFR.V 108 ......AADIGCSRGYLSRHILA...E---SVEQLTLTDTSATMLEQAQGTP.......G---.L 109 ......IIDLGAGFGFLSITLAK...KY---GVKVVAFEYDERMVKLLRKNV.......KLNG.V 110 ......AVDIGAGIGRVSKTMLH...KH---AAKIDLVEPVKPFIEQMHVEL.......AELK.D 111 ......VLDVGCGTGILSIFASK...A---GAARVVGIDN-SDIVYTAMDII.......RKNK.V 112 ......VFDLGTGSGILAMIAAK...K----AKKVYAIELDPFTYDYAKENI.......KVNG.F 113 ......VLDIGCGWGSLTLYIAR...KY--SKCKLTGICNSKTQKAFIDEKC.......RKLG.L 114 ......AFDIGTGSGVLAAILAK...Q---GIPSVIGTDTNPKAVACARANI.......ARLG.F 115 ......AFDIGTGSGVLAAILAK...Q---GIPSVIGTDTNPKAVACARANI.......ARLG.F 116 ......AADCGAGIGRVTENVLL...KI---ASHVDLVEPVENFISTAKKQL.......A---.- 117 ......FYDLGCGDGRVVIEAVK...KT--RVKKAVCVETRDDLVKEARKKA.......EEEG.V 118 ......VYDLGCGDGRIIITAVK...DF--NVKKAIGVEINDERIREALANI.......EKNG.V 119 ......TYDLGAGSGILSFFASE...Y----ADRVIAIERDPKIAACAGENL.......SGLD.- 120 ......ILCLAEGEGRNACFLAS...L----GYEVTAVDQSSVGLAKAKQLA.......QEKG.V 121 ......VLDIGCNNGTVSAQIAS...IF--GASFVLGLDIDHVLIQKARKHL.......E---.- 122 ......VLDLGCAQGFFSLSLAS...K----GATIVGIDFQQENINVCRALA.......EENP.D 123 ......ILDAGCGTGVGTEYLIH...LN--PAAEIVGIDLSEGALEVAEKRC.......QQSG.V 124 ......VLDVGSCFNPFSSA---...----PHLEVTALDLCPATEDVLQADF.......LKVE.V 125 ......VIDLGCGTGRLAIGSKI...L---GAKRAIGIDIDRESIEAAKENA.......KKLN.V 126 ......VLELGAGKGALTTMLSQ...K----AGKVLAVENDSKFVAILTRKT.......AQHP.- 127 ......VLELGAGAGALTTVLSQ...K----AGKVLAVENDSKFVDILTRKT.......AQHS.- 128 ......VLELGAGKGALTTVLSQ...K----AGKVLAVENDSKFVDILTRKT.......AQHS.- 129 ......VLELGAGKGALTTVLSQ...K----AGKVLAVENDSKFVDILTRKT.......AQHS.- 130 ......VLDACAAPGSKTSHILE...VNP-HLKTLVAIDNNKQRLNRIKENI.......TRLG.L 131 ......VLEVGCGTGNLTSALLR...K-----CSVVGIEKDPLMVKRLRERF.......SDFI.G 110 120 130 140 | | | | 1 E.IPV....EILCNDIRH........VEI........KNASMV....ILNFTLQFLPP....EDR 2 E.IPV....EILCNDIRH........VEI........KNASMV....ILNFTLQFLPP....EDR 3 P.TPV....DVIEGDIRD........IAI........ENASMV....VLNFTLQFLEP....SER 4 -.-DI....SFFEANLCE........FDF........FTCDVF....VANYTMQFIRP....PKR 5 -.-NV....RFECMDFLE........VKF........KEASAF....SLLFVLQFVRP....MQR 6 -.-NA....RFECMDFLE........VEF........KEASAF....SLLFVLQFVRP....MQR 7 -.-RC....EVFVMDATL........DHWqvpfee..NSQDII....VMIFVLSAIEP....KKM 8 K.-NI....EFLQGNAMA........LPFek......GSFDVV....TIGYGLRNTP-....-DY 9 K.-NI....EFLQGNAMA........LPFek......GSFDVV....TIGYGLRNTP-....-DY 10 G.-LV....RTIQGDFRS........VSLpn......STYDVL....IAAAVLHHLRDd...EDW 11 H.-NV....KLIHGNAMQ........LPFpd......NSFDYV....TIGFGLRNVP-....-DY 12 -.-RV....CAFACDLTG........DGLdkhisp..SSVDIV....TMIFVLSAVSP....EKM 13 D.KKQ....VFVKGDFMH........MPFed......NTFDYV....YAIEATVHAP-....-SL 14 D.KKQ....VFVKGDFMH........MPFed......NTFDYV....YAIEATVHAP-....-SL 15 D.HKL....SYVKGDFMQ........MDFep......ESFDAV....YAIEATVHAP-....-VL 16 -.--V....DFVHLPVEE........LAGrlea....GSFDAV....FAGYLFRNLT-....-DP 17 -.-YG....HATVWDLAN........PDGnlpdgvepHSVDIA....VMIFVFSALAP....NQW 18 K.CSV....EFEVADCTK........KEYpd......NTFDVI....YSRDTILHIQ-....-DK 19 R.-NI....SLMVMDAET........PGFpa......RSFDLV....MGSYSVIFLP-....-DA 20 R.-NI....SLMVMDAET........PGFpa......RSFDLV....MGSYSVIFLP-....-DA 21 -.-RV....RFLHLTAEE........FATtrede...GPFDAV....FAAYLFRNVT-....-DP 22 R.-NI....ALDVMDAET........PELpa......RSFDLV....MGSYSVIFLP-....-DA 23 A.-MV....ELRVMDGEH........PDFap......HSFDVV....LGSYSVIFLP-....-DA 24 -.-RC....FAFVHDLCD........EEKsypvpk..GSLDII....ILIFVLSAIVP....DKM 25 V.DNF....HSFCCDFSTsef27eskH--ci......GGVDFV....TLIFTLSAVPK....ERM 26 Q.EKI....HVQRANAMK........LPFed......ESFDIV....INEAMLTMLPV....EAK 27 S.DRV....DVVEGDFFE........PLP........RKADAI....ILSFVLLNWPD....HDA 28 -.-RV....FPFVNDITE........DSLlevlgs..ACIDTL....TAIFVLSAIPR....EKQ 29 -.-RC....FAFVHDLCD........EEKsypvpk..GSLDII....ILIFGLSAIVP....DKM 30 S.DRV....DVVEGDFFE........PLP........RRADAI....ILSFVLLNWPD....HDA 31 -.-NV....EFIKAGAQN........LPLes......QSLDIL....SISYGIRNVV-....-ER 32 Q.RRA....EARLQGWEE........FE-........ENVDRI....VSFEAFDAFKK....ERY 33 K.-FC....SASVWDLAG........SDLlrsiee..ASIDAI....TLIFCFSALSP....DQW 34 -.-PL....EFHVRDVAN........MEPl.......GQFDLV....NAAWLFNYADSv...ENL 35 A.DRA....RFQRADAMD........LPFed......ESFDAV....IALESIIHMP-....-DR 36 K.CAV....EFEVADCTK........KDYpe......NSFDVI....YSRDTILHIQ-....-DK 37 P.-HV....EVRVMDGER........PALpe......RSFERV....LGSYSVIFFP-....-EA 38 -.-DH....ETEVSGKFPasf42demLDMiq......PEFDVIlalsITKWIHLNWGD....DGM 39 T.DRV....EIRVQDYRD........VAD........GPYDAI....SSIGMAEHVGA....ERY 40 -.-DH....ETEVSGKFPasf42demLDMiq......PEFDVIlalsITKWIHLNWGD....DGM 41 -.-SI....RFEEGDALR........LPYpd......ASFDAV....TCAFGFRNFA-....-DY 42 Q.RRA....EARLQGWEE........FE-........ENVDRI....VSFEAFDAFKK....ERY 43 T.DQV....RFAGGDFFT........DPL........PRADVF....IVGHILHYFGL....RQR 44 N.-NI....EILHGNLME........VVQ........GKADII....VANIIADVIN-....--- 45 -.--F....SYITSDVTH........LPLpd......NTFRLA....SMAYGLRNLS-....-YP 46 N.-NI....EILHGNLME........VVQ........GKADII....VANIIADVIN-....--- 47 -.--F....SYVISDVTS........MPLpn......DTFHLA....SMAYGLRNLS-....-SP 48 N.SKI....DFLLGEVTN........FHVdg......ASFDVA....TAFFVLQFLHKn...DDV 49 K.-KV....KLLRADVQN........LPFsd......GEYDCV....VSTFVFCTVP-....-DP 50 -.---....-YLAGDIES........LPLat......ATFDLA....WSNLAVQWCG-....-NL 51 -.---....-YLAGDIES........LPLat......ATFDLA....WSNLAVQWCG-....-NL 52 -.-AV....PFEVQDAHA........LTFg.......SEFEAV....FSNAALHWMK-....-PL 53 -.-KA....SFIQAQAKD........LKGven.....NSVDIL....SIAYGLRNVV-....-ER 54 -.-NV....QFVLAEATA........LTFad......QSFDVV....VCGAGLFFVP-....-DM 55 -.-AV....EVELGDIHT........LPLed......GSIDCA....RTDRVLQHVA-....-DP 56 E.-QI....DFQEGDFFK........DPL........PEADLY....ILARVLHDWAD....GKC 57 N.-NI....EILHGNLME........VVQ........GKADII....VANIIADVIN-....--- 58 E.-NV....EFRLGEIGH........LPVad......ESVNVV....ISNCVVNLAP-....-EK 59 N.KGV....EHVSGDMFK........-EI........PKGDAI....FMKWILHDWTD....EDC 60 -.-NF....AFQRVDIAHely15alkLPYad......GHFDFV....IMTSIVTHLPP....DEV 61 N.RSR....QVLLQGWED........FA-........EPVDRI....VSIEAFEHFGH....ENY 62 -.-YF....TFEQGSAQE........IPFdn......ESFDLI....ICSASFHHFP-....-KP 63 -.-PV....ELKEMDVSL........IKPr.......TKYDVA....IMSFLLEYVK-....-DR 64 -.-PA....ELKEMDVSL........IRTr.......SKYDVA....IMSFLLEYVR-....-DR 65 -.-NV....EFIIGDAKK........LPFed......NNFDYV....IFIDSLVHFSP....LEL 66 N.RSR....QVLLQGWED........FA-........EPVDRI....VSIEAFEHFGH....ENY 67 T.GRV....DFVGGDFFT........DAL........PAADVV....LFGHVLHDHPE....ESR 68 E.-NT....GFAVADVHA........LDYpd......DTFCVV....HAHQVLQHVG-....-DP 69 A.GRA....QAFGGDFFA........DELp.......RGADVI....SLVRVAFDHPD....ERV 70 E.DKI....EIRLQNYQD........LEFe.......NYFDKV....VSVGMFEHVGK....ENL 71 -.-QA....TYVQGLAED........LPFge......GEFDLV....HTSVALHEMTP....AQL 72 -.--A....VFLTGDAAA........PPVge......QRFDAV....LVRHVLWTLP-....-DP 73 T.DRV....ETRQADLRT........LDAq.......PQFDLV....TLHNNIYYFPE....AER 74 -.-AL....EFRHGDAQL........LAGmedla...GKADLV....VSRNAFHRLT-....-RL 75 D.-AI....EYLKS----........LPD........KYLDGV....MISHFVEHLDP....ERL 76 D.VEV....EKIVGDAKK........VGElve.....EHDVAV....LFGLTMPHFNA....FDA 77 R.NQI....QLKEGDAAD........VLQelk.....GPFDLV....FMDSAKS----....-KY 78 -.-NV....KFMCADVTS........PSLnisp....NSVDII....FSNWLLMYLSD....EEV 79 A.DRV....DFHGGDFFA........TDL........PEADVV....IFGHVLPDWPV....GDR 80 -.-NV....EFIVGDARK........LSFed......KTFDYV....IFIDSIVHFEP....LEL 81 -.-KI....EFLQGDVLE........IAFk.......NEFDAV....TMFFSTIMYFDe...EDL 82 S.GRF....SLYHLPIEK........LAElpe.....SHFDVI....TSSFAFHYIE-....-NF 83 -.-QV....ELRETDFLT........YLGeanqtap.ASFDLI....HVGFSLHHLLP....EEK 84 E.GRI....ELKFQDYRL........VK-........EKYTRV....VSIEMIEAVGE....KYL 85 -.-AH....HYLLGDIEQ........VPLpd......AAMDIC....FSSLVVQWCS-....-DL 86 -.-NF....QFEVSDIYNsly15dfrFPYpd......ASFDVV....FLTSVFTHMFP....PDV 87 D.-FV....DIRAGDAFT........LPVpd......NSVDVV....AQNCLFNIFEP....EDL 88 D.-NS....EFHVLALED........LDQlg......QKFDYI....SASDILYLLP-....-DL 89 -.-DC....QFVEADIRN........WQPv.......QALDLI....FANASLQWLP-....-DH 90 N.-NC....SFRLGSIYK........LPFpd......NTFDIV....NTHQVLVHLQ-....-DP 91 Y.VIP....GEKLLDASE........IPS........ESFDVV....FSNAALHWIMRqp..KNR 92 D.---....----GHFLS........IPLld......GTADAV....ISTYTFHHVPD....EEK 93 E.-LA....SNVVYKIEP........VDQhakanc..ECYDAV....IVSEVLEHVK-....-DK 94 TyKNV....SFKISSSDD........FKFlgadsvdkQKIDMI....TAVECAHWF--....-DF 95 K.-NI....EFHHCSITD........IDDsf......GKFDYI....ICHGVISWVPK....IVR 96 K.-NI....EFHHCSITD........IDDsf......GKFDYI....ICHGVISWVPK....IVR 97 K.-NI....EILRDDIRH........LAHvf......KDNQFI....VMNNVFSFFLSk...TEQ 98 A.-NT....DFRHGYIED........LAGagipd...ASVDVV....VSNCVVNLSP-....-DK 99 A.-RL....SLWNADTLA........AHA........HSADII....WLNNALHRLLP....EDP 100 -.-RL....QVISRSAER........LE-........RHYDVI....FSCLPLLSIPV....IPR 101 A.-RL....SPWNADTLA........AHA........HSGDII....WLNNALHRLLP....EDP 102 A.-RL....SPWNADTLA........AHA........HSGDII....WLNNALHRLLP....EDP 103 P.GSI....DFRSGDMLD........PAL........GRFDHV....IAMDSVIHYDA....PDA 104 -.-NL....RFEQGDIQE........LS-........GSFDLL....YSNAALQWLP-....-DH 105 -.-AA....TFRCADIRD........VPLad......ESFDAV....CVYFSLLQLDR....AEQ 106 -.-QS....SFHHLNVTD........FQLd.......EKFHVA....TAVFVLQYVHDk...EEL 107 -.-DA....HTVHGKAPE........GLNef......ADPDAV....FIGGTAG----....-GM 108 -.-KM....VKLVKDEEQ........LDFed......NSLDLV....ISSLSLHWVN-....-DL 109 E.HLV....EVVEGDIKE........IEKhlsr....GSFNLV....VSNPPFYPINYs...PNP 110 K.GQIg...QIYEVGMQD........WTPda......GKYWLI....WCQWCVGHLPD....AEL 111 E.-NV....ELIKGRLED........TDLpe......TKYDII....ISEWMGYFLLY....ESM 112 N.-NI....EIIEGDAST........YNFk.......EKADVV....IAELLDTALII....EPQ 113 Q.-NV....EIIAADIST........FEHe.......GTYDRI....FSIEMFEHMK-....-NY 114 E.KQV....EIRETDLFPegf13ppwLPA........KPTSAV....ESALYDPESA-....-ML 115 E.KQV....EIRETDLFPegf13ppwLPA........KPTSAV....ESALYDPESA-....-ML 116 T.KPC....SFINVGLQN........WTPek......NRYGLI....WNQWCLSHLTD....EDL 117 S.DRI....EFINNDFFK........TPL........KDATAV....YMYLLTSVNE-....--- 118 T.GRA....SIVKGNFFE........VDI........SEATVV....TMF--------....--- 119 -.-NV....SVVNEDALH........YEF........SAADTI....ICEMLDTALID....EEQ 120 -.-KI....TTVQSNLAD........FDIva......DAWEGI....VSIFC--HLPS....SLR 121 -.-FV....SSRIGPVRNpgs49flrWESk.......RKFKIIlalsVSKWVHLNNHD....EGI 122 F.-AA....EFRVGRIEE........VIAalee....GEFDLA....IGLSVFHHIVHlhgiDEV 123 R.DRHtapvTFKRLPIEQ........ATEle......GEFDLI....NCVGVLHHMP-....-D- 124 V.PGIrep.ELEEGSVRR........LPA........SHYECV....IFSLLLEYMPSa...EQR 125 -.-DV....DFYCMDIRDvdd.....---........------....-----------....--- 126 -.-NT....KIIHQDIMK........IHLpk......EKFVVV....SN---------....--- 127 -.-NT....KIIHQDIMK........IHLpk......EKFVVV....SN---------....--- 128 -.-NT....KIIHQDIMK........IHLpk......EKFVVV....SN---------....--- 129 -.-NT....KIIHQDIMK........IHLpk......EKFVVV....SN---------....--- 130 -.-RQ....EHLQCLLADvsq45isq---........------....-------YHQ-....-KK 131 K.GRF....RLIQGDALK........VDF........PYFTK-....-----------....--- 150 160 170 180 | | | | 1 IALLTKIYE........GLNPNGVLVLSEK...F.RFED.TKI.....NHL.....LIDLHHQFK 2 IALLTKIYE........GLNPNGVLVLSEK...F.RFED.TKI.....NHL.....LIDLHHQFK 3 QALLDKIYQ........GLNPGGALVLSEK...F.SFED.AKV.....GEL.....LFNMHHDFK 4 QELLDQIYK........NLNSKGILIMSEK...I.LYED.AFL.....SKN.....IIELYADYK 5 EVLLKKIYN........SLALNGVLLVGEK...I.MSED.RIL.....DKQ.....MIELYYLYK 6 EVLLKKIYN........SLALNGVLLVGEK...I.MSED.RIL.....DKQ.....MIELYYLYK 7 QRVLDNCYR........YLRPGGLLLFRDY...G.RYDL.AQL.....---.....--------- 8 LTVLKEIFR........VLKPGGRVVCIET...S.HPTL.PIY.....KQA.....FELYFKNVM 9 LTVLKEIFR........VLKPGGRVVCIET...S.HPTL.PIY.....KQA.....FELYFKNVM 10 RQAFQKIYN........LLAPGGSVWITDL...V.SHEQ.PAV.....QAM.....MWDRYGDYL 11 MTVLKEMHR........VTKPGGITVCLET...S.QPTL.FGF.....RQL.....YYFYFRFIM 12 SSVLQNIRK........VLKPNGCILFRDY...A.VGDL.AQE.....---.....--------- 13 EGVYGEIFR........VLKPGGVFGVYEW...V.MSDD.YDS.....---.....--------- 14 EGVYGEIFR........VLKPGGVFGVYEW...V.MSDD.YDS.....---.....--------- 15 EGVYSEIYK........VLKPGGIFGVYEW...V.MTDK.YDE.....---.....--------- 16 DEALDMLHG........LLVPGGRLAVHEY...T.LGGS.PVH.....RAV.....WSAVCSLII 17 DQAMDNLHK........ILKPGGKIIFRDY...G.AYDL.TQV.....---.....--------- 18 PALFRRFYK........WLKPGGKVLITDY...C.RSPK.TPS.....---.....--------- 19 VGALARYAD........ILDHGGRIAFTSP...V.FRAG.TFPflp..PEF.....TPLIPQALL 20 VGALARYAD........ILDHGGRIAFTSP...V.FRAG.TFPflp..PEF.....TPLIPQALL 21 DAVLRAVRQ........LLRPGGRFAAHEY...S.LSGS.PGH.....RAL.....WSAVCRGVV 22 VGALARYAG........ILDHGGRIAFTSP...V.FRAG.TFPflp..PEF.....TPLIPQALL 23 PTALARYAP........LLSPGGRLAFTSP...V.FSDD.TFPflp..PVF.....TELIPRELL 24 QKAINRLSR........LLKPGGMVLLRDY...G.RYDM.AQL.....---.....--------- 25 PRAIKECFA........VLKPGGLLLFRDY...G.LYDM.TML.....---.....--------- 26 KKAIAEYFR........VLKPNGLLLTHDV...M.LVGN.DHQ.....TIL.....--------- 27 VRILTRCAE........ALEPGGRILIHER...D.DLHE.NSF.....NEQ.....FTELDLRML 28 LRSIKNLAS........VIKPGGHLVFRDY...C.DGDF.AQE.....K--.....-------FM 29 QRAINRLSR........LLKPGGMMLLRDY...G.RYDM.AQL.....---.....--------- 30 VRILTRCAE........ALEPGGRILIHER...D.DLHE.NSF.....NEQ.....FTELDLRML 31 QKALSEFAR........VLQKDGILVVLEF...T.KREK.GGF.....IAA.....CRDFYLKNI 32 LTFFERSYD........ILPDDGRMLLHSL...F.TYDR.RWL.....HEQ.....GIALTMSDL 33 QQAIENLYR........LLKPGGLILFRDY...G.RLDL.TQL.....---.....--------- 34 RKMFKVVRA........SLKPDGKLVAYTVdpdF.SLAK.GNF.....AKY.....GVNVLNERA 35 AQVLAQVGR........VLRPGGRLVLTDF...F.ERAP.LAP.....---.....--------- 36 PALFRSFHK........WLKPGGKVLISDY...C.KSAG.TPS.....---.....--------- 37 LPALVRYAG........LLADGGRIAFTSP...V.FTED.TFPflp..PVF.....TELIPRSLL 38 RRFFRRAYA........QLHPGGRLIIEPQ...A.FDSY.KKR.....AKM.....--------- 39 LEYATDLHR........LLKPGGRLLNHQI...A.RRPQ.RDE.....SSY.....NVDEFIDAY 40 RRFFRRAYA........QLHPGGRLIIEPQ...A.FDSY.KKR.....AKM.....--------- 41 TQGLAEMWR........VLTPGGRLVLLEF...P.PPAS.GLF.....GAV.....FRLYFQHVL 42 LTFFERSYD........ILPDDGRMLLHSL...F.TYDR.RWL.....HEQ.....GIALTMSEL 43 EALIARIHQ........ALTPGGAVLVYDR...M.IDDD.RRS.....AAL.....SLLGSLNML 44 -ILIPDINK........FLKTDGYFI----...-.----.---.....---.....--------- 45 LEALREVYR........VLQPGGHLGILEL...T.RPAT.YNP.....VYL.....LHKLYLNLV 46 -ILIPDINK........FLKTDGYFI----...-.----.---.....---.....--------- 47 LEALKEVHR........VLKPKGRLGILEL...T.RPAT.YNP.....VHL.....LHKLYLNLV 48 ALAIQNISR........HLKSRGTFFGLIP...N.GVPG.VRA.....PEN.....MGLKLGAQI 49 VKGLKEVHR........VLRPSGKAVFLEH...M.RSRK.WYV.....NVI.....LFLMHIFTK 50 STALRELYR........VVRPKGVVAFTTL...V.QGSL.PEL.....HQA.....WQAVDE--- 51 STALRELYR........VVRPKGVVAFTTL...V.QGSL.PER.....HQA.....WQAVDE--- 52 PPVFGRVAA........ALKPGGRFVLEMG...G.AGNVqTTL.....DAV.....AHATHKLGL 53 QEALKEFFR........VLKPRGVLVILEF...LkKDNP.TWL.....DKI.....SGFYTNKVL 54 VAALREWRR........VLRPGGEVVFSAF...G.RGLL.GPL.....---.....--------- 55 AQALAEARR........VLRPGGRLVMGEP...D.WDSL.TID.....---.....--------- 56 SHLLERIYH........TCKPGGGILVIES...L.LDED.RRG.....PLL.....TQLYSLNML 57 -ILIPDINK........FLKTDGYFI----...-.----.---.....---.....--------- 58 QRVFDDTYR........VLRPGGRVAISDV...V.QTAP.FPD.....DVQ.....MDPD----- 59 VKILKNYWK........SLPEKGKVIIVEV...V.TPEE.PKIndissNIV.....FGMDMLMLA 60 LVYLREVGR........LLKPGGRLFMTAF...V.VDHV.AAA.....---.....--------- 61 DDFFKRCFN........IMPADGRMTVQSS...V.SYHP.YEM.....AAR.....GKKLSFETA 62 ERFLLEAEC........LLSPNGRLVIAEI...H.IPFI.TK-.....---.....--------- 63 REVLRKVLE........ALDSGGKLVIVDA...F.RDEF.KNI.....EAM.....--------- 64 EEVLGKVLE........ALDSGGKLIIVEA...F.RDEF.ENI.....QAM.....--------- 65 NQVFKEVKR........VLKPTGKFIIY--...-.----.---.....---.....--------- 66 DDFFKRCFN........IMPADGRMTVQSS...V.SYHP.YEM.....AAR.....GKKLSFETA 67 KRLLGQAFR........ALPPGGTLLVYDA...M.LDDR.SEA.....GAY.....LQSLVCSVI 68 VRALREMRR........VARPGGFIAVRDS...D.YGAM.TWY.....PASsgmddWLDLYHRVA 69 LTLFKNVRR........ALPDNGTLVLAEA...-.MAEV.PGV.....EPI.....GDAYFGFYL 70 GLYFMKVKQ........VLKPGGSMLLHSI...L.AMFE.GKT.....N--.....--------- 71 QSIISGVHR........VLKPGGIFALVDL...H.RPSN.WLF.....WPP.....LAIFMGLFE 72 GRALRHWRQ........LLRPGGRLVLVEG...V.WGSV.SPV.....GIP.....ADRVTALLG 73 VEALRRAHD........LLAPGGRLLLTTS...C.KGGN.VGL.....EAL.....--------- 74 PAAFDTMLR........LAKPGGAVLNCSF...I.HPSD.FDE.....SGF.....RAWVTFLNQ 75 FELLSLCYS........KMKYSSYIVIESP...N.PTSL.YSL.....---.....--------- 76 VKLFAGVAS........ILSENGVFILEE-...-.--TD.RVY.....GIM.....YLVGYKDFL 77 VEFLPKSLE........LLSENGLILMDDV...F.QAGE.ILL.....PIM.....--------- 78 ERLVERMLK........WLKPGGYIFFRES...C.FH--.---.....---.....--------- 79 RELLRRAHK........AVRPGGLVVLYDA...M.IDPE.ERD.....PEV.....LLQR----- 80 NQVFKEVRR........VLKPSGKFIMY--...-.----.---.....---.....--------- 81 RKLFSKVAE........ALKPGGVFI----...-.----.---.....---.....--------- 82 PTLLSTIHD........KLSSNGTLIFS--...-.----.---.....---.....--------- 83 EQFFAHCFS........LLRPGGCLVIYDV...F.RQPE.QNR.....QQY.....IEAYL---- 84 PQYFQIIND........VLTDGGIAALQAI...T.CPDA.YYD.....QYR.....SSSDFIKKY 85 PAALAELYR........VTRPGGVILFSTL...A.AGSL.QEL.....GDA.....WQQ------ 86 EHYLDEISR........VLKPGGRCLC-TY...F.LLND.ESL.....AHI.....AEGKSAHNF 87 SRALKEAYR........VLKPHGRLIMSDP...I.A-AR.PIP.....QHL.....RQDERLRAM 88 TLALQQLRA........ILKPDGII-----...-.----.---.....---.....--------- 89 YELFPHLVS........LLNPQGVLAVQMP...D.NWLE.PTH.....---.....--------- 90 VAALVELKR........VTKPGGYVCCKEA...D.LLSA.CVY.....PKE.....Y-------- 91 PIVMKGVSR........VLRTKGRFV-AEC...G.AFGN.VSE.....VVG.....SIYSILLAL 92 EDAIKEMLR........VLNPGGRIVIADV...M.FESE.---.....---.....--------- 93 VSLLEASVR........SLKPGGSIFITTL...N.KTIP.SWF.....GGV.....LLSEYVLNL 94 EKFQRSAYA........NLRKDGTIAIWGY...A.DPIF.PDY.....---.....--------- 95 DKIFKVCNR........NLSTNGIAYIS--...-.----.---.....---.....--------- 96 DKIFKVCNR........NLSTNGIAYIS--...-.----.---.....---.....--------- 97 EECWEFLHT........HMRPGTVLAHH--...-.----.---.....---.....--------- 98 PRVLSEIFR........VLKPGGELYFSDI...-.-FSD.RRL.....PAS.....LLDDPVLVG 99 -GLLATLQQ........LAVPGALLYVMEF...R.QLTP.SAL.....---.....--------- 100 LRILNRVRE........RLNPGGVFIQFQY...S.PLSE.KLL.....SRY.....FEWTRVYEV 101 -GLLATLQQ........LAVPGALLYVMEF...R.QLTP.SAL.....---.....--------- 102 -GLLATLQQ........LAVPGALLYVMEF...R.QLTP.SAL.....---.....--------- 103 VAALSRLAE........-------------...-.----.---.....---.....--------- 104 PRLLARLWE........HLRPGGVLAVQVP...A.N---.---.....---.....--------- 105 KDLVRRLVR........LLRPGGHLVLATV...P.L---.---.....---.....--------- 106 RKAIRLIW-........-------------...-.----.---.....---.....--------- 107 ETILDVCCS........RLNSGGRIVL---...-.----.---.....---.....--------- 108 PGCFVRIKQ........SLKPDGVFIASMF...G.GDTL.YEL.....---.....--------- 109 EPYHFEVYAtlk11ssyLLKDGGELYLLSP...C.----.---.....---.....--------- 110 VAFLKRCIV........GLQPNGTIVVKEN...N.TPTD.TDDf....---.....--------- 111 LDSIIYAREn.......HLNPNGIILPS--...-.----.---.....---.....--------- 112 VKVMN----........-------------...-.----.---.....---.....--------- 113 GELLKKIGN........WMKEDSLLFVHYL...-.----.---.....---.....--------- 114 AAFLRDAPK........HLNPDGEIRLIIS...D.LAEH.LH-.....---.....--------- 115 AAFLRDAPK........HLNPDGEIRLIIS...D.----.---.....---.....--------- 116 IAYLSRCCE........AIQEKGVICVKEN...V.S---.---.....---.....--------- 117 -SLKPKLAR........ELRDGTRIVTLDF...P.----.---.....---.....--------- 118 --LLTNVNE........MLKP---------...-.----.---.....---.....--------- 119 VPVLRRALK........FLRNDGTVIPQAV...F.NAAE.PVT.....---.....--------- 120 QQLYPKVYQ........GLKPGGVFILEGF...-.----.---.....---.....--------- 121 IKFFGKISS........LLETNGVLILEPQ...G.WDSY.LKA.....---.....--------- 122 KRLLSRLAD........-------------...-.----.---.....---.....--------- 123 ---------........-------------...-.----.---.....---.....--------- 124 LQCCLQAYD........LLLPEGILVLITP...D.SQHV.GKN.....AHL.....MKNWRYSLA 125 ---------........-------------...-.----.---.....---.....--------- 126 ---------........-------------...-.----.---.....---.....--------- 127 ---------........-------------...-.----.---.....---.....--------- 128 ---------........-------------...-.----.---.....---.....--------- 129 ---------........-------------...-.----.---.....---.....--------- 130 LQLLNALWT........VLKAGGFLLYSTC...S.VLPD.ENE.....KVI.....EEFLSTHDK 131 ---------........-------------...-.----.---.....---.....--------- 190 200 210 220 230 | | | | | 1 ......RANG.YSEL..EVS..QKRTA...LENVMRTDSIETHKVRLK.NVGFSQVELWFQCFNF 2 ......RANG.YSEL..EVS..QKRTA...LENVMRTDSIETHKVRLK.NVGFSQVELWFQCFNF 3 ......RANG.YSEL..EIS..QKRSM...LENVMLTDSVETHKARLH.NAGFEHSELWFQCFNF 4 ......EKQG.YSKF..EIA..AKREA...LENVLIPYSQKENLNMLE.KAGFKKIESIFKWANF 5 ......QNQG.YSHN..EIA..FKREA...LENVLVPYSLKENIALLE.SVGFKHVEALFKWVNF 6 ......QNQG.YSHN..EIA..FKREA...LENVLVPYSLKENVALLE.SVGFKHVEALFKWVNF 7 ......RFKS.GKCM..EDN..FYVRG...DGTMVYFFTEEELRGMMT.QAGLQEEQ-------- 8 ......PFLG.KVFAk.SLK..EYQWL...QKSAEDFPDAKTLEELFR.KAGFVAVEYQ------ 9 ......PFLG.KVFAk.SLK..EYQWL...QKSAEDFPDAKTLEELFR.KAGFVAVEYQ------ 10 ......VSLG.GAEY..R-D..KVFGY...IDREDSPRPVTYQLDLLR.SVGFDAVDLLHKNSCF 11 ......PLFG.KLLAk.SYE..EYSWL...QESAREFPGRDELAEMFR.AAGFVDVEVKPYTFGV 12 ......RFSGkDQRI..SEN..FYVRG...DGTRAFYFSNEFLETLFS.EQGFEVEELDVCCK-- 13 ......--SI.PKHR..EIA..YNIEV...GDGIPQMVRKCDAVEAIK.KVGFNLLE-------- 14 ......--SI.PKHR..EIA..YNIEV...GDGIPQMVRKCDAVEAIK.KVGFNLLE-------- 15 ......--TN.EEHR..KIA..YGIEV...GDGIPKMYSRKVAEQALK.NVGFE----------- 16 ......QPAG.RLTG..DAG..LYRHL...RDSVTRFDTAPAFAQRLR.RAGFADVRVL------ 17 ......RFKK.NRIL..EEN..FYVRG...DGTRVYFFSEEKLREIFT.---------------- 18 ......----.----..-PD..FAIYI...KKRGYDLHDVQAYGQMLR.DAGFEEV--------- 19 ......EHLP.EQWR..PEA..LVRRF...NSWLER---AEDLVRTLE.GCGYA----------- 20 ......EHLP.EQWR..PEA..LVRRF...NSWLER---AEDLVRTLE.GCGYA----------- 21 ......IPAG.TLTG..DRT..LYRHL...RRSVVAFDTAPEFAARLT.RAGLTSVR-------- 22 ......EHLP.EQWR..PEA..LVRRF...NSWLER---AEDLLRTLE.RCGYTSV--------- 23 ......LDLP.PQWQ..PEQ..LQQRF...NSWLAD---PRDLTRTLE.RCGFQEVT-------- 24 ......RFKK.GQCL..SGN..FYVRG...DGTRVYFFTQEELDTLFT.TAGLEKVQ-------- 25 ......RFEP.EKRV..GFR..EYVRS...DGTLSYFFCLDTARKLFT.DAGFIEVELEYCC--- 26 ......----.----..--E..NMRKA...INVTVTPLTKDGWKGIFQ.ESGFRNVD-------- 27 ......VFLG.GALR..TRE..KWDG-...---------------L--.---------------- 28 ......TSGD.PSMI..DEQ..TFVRQ...DGTLSLFFREEDIAEWMK.SAGFGLVT-------- 29 ......RFKK.GQCL..SGN..FYVRG...DGTRVYFFTQEELDTLFT.TAGLEKVQ-------- 30 ......VFLG.GALR..TRE..KWDG-...---------------L--.---------------- 31 ......LPSI.GGIIskNKS..AYEYL...PNSIEGFLSKKEFILELK.NAGFEMLDYKSFSFGV 32 ......RFLK.----..---..FLRES...IFPGGELPSEPDIVDNAQ.AAGFTIEHV------- 33 ......RAKK.NRIL..SEN..FYIRG...DGTRVLIVNRK-------.---------------- 34 ......WGPG.YRHD..AEF..VTDPP...SQFSFYRWSRADYESAIA.DAGFSHFEWQKPLLEA 35 ......----.--EG..RAA..VQRYL...HDFMMTMVSAEAYPPLLR.GAGLWLEE-------- 36 ......----.----..-AE..FAAYI...RQRGYDLHDVKAYGKMLK.DAGFVE---------- 37 ......DTLP.PDWR..PEA..LRRRF...NSWLER---PDDLEATMR.RAGFGEV--------- 38 ......----.----..--S..EELKA...NYSKIEFKPEDFEMWLIE.TVGFESVE-------- 39 ......VFPD.GELA..P--..-----...---------VGTTVTQLE.RAGFEVRDVESIREH- 40 ......----.----..--S..EELKA...NYSKIEFKPEDFEMWLIE.TVGFESVE-------- 41 ......PRIG.ALVSg.NAG..AYTYL...PESVLAFPEPERLAQMMR.ATGFR----------- 42 ......PIPQ.----..---..ILRES...IFPGGELPSEPDIVDNAQ.AAGFTIEHV------- 43 ......LTSD.E---..---..-----...----GREYTPAECVRWLS.DAGFTDVR-------- 44 ......----.----..---..-----...-SSGIIKDRAEDVIENLK.KNKFEIIE-------- 45 ......VPSV.GRFY..SGNsyAYSYL...KESIRDLPRDAALEAIFH.AAHLRPIRKRKLLFGT 46 ......----.----..---..-----...-SSGIIKDRAEDVIENLK.KNKFEIIE-------- 47 ......VPSV.GRFY..SGNsyAYSYL...KESIRNLPCDTSLERVFH.KSGLHIIRKRKLLFGT 48 qkepesPFVD.GEVV..GIN..FYANGevcGSSKIALHSREFYEQCFK.AAGFSQIEWIAPHF-- 49 ......LLLG.TSML..---..-----...----------RKTVDNIK.KAGFVIEEEKYLLSDV 50 ......RPHA.NRFL..PPD..EIEQS...LNGVHYQHHIQPITLWFD.D--------------- 51 ......RPHA.NRFL..PPD..EIEQS...LNGVHYQHHIQPITLWFD.D--------------- 52 ......PELP.PPWV..---..-----...------FPTAGELCTGLE.AAGMRVE--------- 53 ......PLVG.GAISk.NYG..AYSYL...PQSIEGFLSLEGLKHELR.NAGFEILRTEDSIAQI 54 ......PGLW.RERL..AGE..GVKPG...APPLGRIGTVEAAKDLLI.QAGFAEVTAELT---- 55 ......--YP.DLEV..SRA..YTRHV...TDKIVRNGVIGRQLARLAlDAGFAVP--------- 56 ......VQTE.GQER..T--..-----...---------PTHYHMLLS.SAGFRDFQFKKTGAIY 57 ......----.----..---..-----...-SSGIIKDRAEDVIENLK.KNKFEIIE-------- 58 ......----.----..---..---SL...TGCVAGASTVDDLKAMLD.EAGFEAVEI------- 59 ......VSSG.GKER..SLS..QFE--...--------------TLAS.DSGFLRCEIICHAFSY 60 ......NESG.RRDA..RLS..FARDG...DGPCWYVPDMPRLAAVGF.DDGF------------ 61 ......RFIK.----..---..FIVTE...IFPGGRLPSTEMMVEHGE.KAGFTVPEPLSLRPH- 62 ......----.--IY..NWW..INRFS...TEGDVKVYQPKELTELFN.QNGWK----------- 63 ......----.----..--E..FFEGL...NSSFVGYPGKEEVKRIIL.EEGF------------ 64 ......----.----..--E..FFESL...NRSFVGYPAKAEIKKAIL.REGF------------ 65 ......----.----..---..-----...------------------.---------------- 66 ......RFIK.----..---..FIVTE...IFPGGRLPSTEMMVEHGE.KAGFTVPEPLSLRPH- 67 ......LDGG.SEYR..---..-----...---------VRDITAWAE.ETGFTVEQ-------- 68 ......RANG.----..---..-----...----GEPDAGRRLKAWAL.EAGFTDITATSATWTF 69 ......LAMG.----..---..-----...---RGRPRSAARLTQMLH.EAGFASVRPLSTHMPL 70 ......----.----..--A..WIDKY...IFPGGYLPSLREVVSAMS.EWDFHLLLAESLR--- 71 ......TETA.WQLI..N--..-----...----------TDLGSLLD.QAGFTVVR-------- 72 ......PLTG.Q---..---..-----...------------------.---------------- 73 ......----.----..--N..LWFTY...ADFGGPLPQADALADQLR.QAGFDDVEA------- 74 ......RPWD.SEMQ..---..-----...------------------.---------------- 75 ......----.----..---..INFYI...DPTHKKPVHPETLKFILE.YLGFRDVKIEFFEE-- 76 ......VETK.GKDY..TLI..SVHEG...YDPVKGVFKRTYYKLP--.---------------- 77 ......----.----..---..-----...------------------.---------------- 78 ......----.----..---..-----...------------------.---------------- 79 ......----.----..---..INHTM...IRDEAGAYSLQEARAYLE.EAGFT----------- 80 ......----.----..---..-----...------F-----------.---------------- 81 ......----.----..---..-----...------------------.---------------- 82 ......----.----..---..-----...------------------.---------------- 83 ......----.----..---..A----...------------------.---------------- 84 ......IFPG.GHLP..SLG..AISQS...L-----------------.---------------- 85 ......----.----..---..-----...------------------.---------------- 86 ......QHEG.PGYR..TIH..K----...------------------.---------------- 87 ......CLSG.----..---..-----...------ALTYAEYIQHLI.DTGFGQIEI------- 88 ......----.----..---..-----...------------------.---------------- 89 ......----.----..---..-----...------------------.---------------- 90 ......----.----..---..-----...------------------.---------------- 91 ......GATK.EQID..QAN..PWF--...------FGSEDDYTRMLE.EAGF------------ 92 ......----.----..---..-----...------------------.---------------- 93 ......VPRG.THHW..---..-----...------------------.---------------- 94 ......PEFD.DLMI..EVP..YGKQG...LGPYWEQPGRSRLRNMLK.D--------------- 95 ......----.----..---..-----...------------------.---------------- 96 ......----.----..---..-----...------------------.---------------- 97 ......----.----..---..-----...------------------.---------------- 98 ......ECLA.GALY..T--..-----...----------EDFRRAL-.---------------- 99 ......----.----..---..-----...------------------.---------------- 100 ......RNIP.PAW-..---..-----...------------------.---------------- 101 ......----.----..---..-----...------------------.---------------- 102 ......----.----..---..-----...------------------.---------------- 103 ......----.----..---..-----...------------------.---------------- 104 ......----.----..---..-----...------------------.---------------- 105 ......----.-DVE..GVD..ATFMG...QPVRVTSFPAQELIALAE.EAGLEV---------- 106 ......----.----..---..-----...------------------.---------------- 107 ......----.----..---..-----...--NAVTIENLAEAMKAFK.ERGFE----------- 108 ......-RSS.LQLA..ELE..RKGGI...SPHISPFTQIRDIGSLLN.RAGFTML--------- 109 ......----.----..---..-----...------------------.---------------- 110 ......----.----..---..--DE-...-TDSSVTRSDAKFRQIFE.EAGLK----------- 111 ......----.----..---..-----...------------------.---------------- 112 ......----.----..---..-----...------------------.---------------- 113 ......----.----..---..-----...------------------.---------------- 114 ......----.----..---..-----...------LRPSDFLDKAFA.QAG------------- 115 ......----.----..---..-----...------------------.---------------- 116 ......----.----..---..-----...------------------.---------------- 117 ......----.----..---..-----...------------------.---------------- 118 ......----.----..---..-----...------------------.---------------- 119 ......VNFE.NIMY..DEN..LSQPS...SGPMRVYDRVE-------.---------------- 120 ......----.----..---..-----...------------------.---------------- 121 ......----.----..---..-----...------------------.---------------- 122 ......----.----..---..-----...------------------.---------------- 123 ......----.----..---..-----...------------------.---------------- 124 ......----.----..---..-----...------------------.---------------- 125 ......----.----..---..-----...------------------.---------------- 126 ......----.----..---..-----...------------------.---------------- 127 ......----.----..---..-----...------------------.---------------- 128 ......----.----..---..-----...------------------.---------------- 129 ......----.----..---..-----...------------------.---------------- 130 ......VEL-.----..---..-----...------------------.---------------- 131 ......----.----..---..-----...------------------.---------------- 240 | 1 GSMIAVK 2 GSMIAVK 3 GSLVALK 4 ETFIAFK 5 TLLVARK 6 TLLVARK 7 ------- 8 ------- 9 ------- 10 AAFGAVK 11 AAM---- 12 ------- 13 ------- 14 ------- 15 ------- 16 ------- 17 ------- 18 ------- 19 ------- 20 ------- 21 ------- 22 ------- 23 ------- 24 ------- 25 ------- 26 ------- 27 ------- 28 ------- 29 ------- 30 ------- 31 SSMFIAK 32 ------- 33 ------- 34 D------ 35 ------- 36 ------- 37 ------- 38 ------- 39 ------- 40 ------- 41 ------- 42 ------- 43 ------- 44 ------- 45 ATIWIL- 46 ------- 47 ATIWIL- 48 ------- 49 VRLIIA- 50 ------- 51 ------- 52 ------- 53 STTMLVK 54 ------- 55 ------- 56 DAILARK 57 ------- 58 ------- 59 SVIELHK 60 ------- 61 ------- 62 ------- 63 ------- 64 ------- 65 ------- 66 ------- 67 ------- 68 ------- 69 QAGV--- 70 ------- 71 ------- 72 ------- 73 ------- 74 ------- 75 ------- 76 ------- 77 ------- 78 ------- 79 ------- 80 ------- 81 ------- 82 ------- 83 ------- 84 ------- 85 ------- 86 ------- 87 ------- 88 ------- 89 ------- 90 ------- 91 ------- 92 ------- 93 ------- 94 ------- 95 ------- 96 ------- 97 ------- 98 ------- 99 ------- 100 ------- 101 ------- 102 ------- 103 ------- 104 ------- 105 ------- 106 ------- 107 ------- 108 ------- 109 ------- 110 ------- 111 ------- 112 ------- 113 ------- 114 ------- 115 ------- 116 ------- 117 ------- 118 ------- 119 ------- 120 ------- 121 ------- 122 ------- 123 ------- 124 ------- 125 ------- 126 ------- 127 ------- 128 ------- 129 ------- 130 ------- 131 -------