; SAM: prettyalign v3.1b (February 24, 1999) compiled 04/18/00_11:44:15 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ------ Citations (HMMs, SAM) ------ ; A. Krogh et al., Hidden Markov models in computational biology: ; ------------- Citations (SAM, SAM-T99, HMMs) ----------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; -------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 gi|7499036|pir||T20865_92:266 ; 2 gi|7446142|pir||H71287_48:208 ; 3 gi|7446155|pir||H69524_18:160 ; 4 gi|4502125|ref|NP_001152.1|_22:133 ; 5 gi|1703327|sp|P50584|AP4A_PIG_25:131 ; 6 gi|7490320|pir||T39685_219:350 ; 7 gi|7480112|pir||T36827_2:170 ; 8 gi|2496946|sp|Q09297|YQO8_CAEEL_84:213 ; 9 gi|1176862|sp|P45799|YRFE_ECOLI_31:175 ; 10 gi|7466320|pir||A65002_25:179 ; 11 gi|7481085|pir||T36787_25:142 ; 12 gi|7473172|pir||E75562_20:157 ; 13 gi|7023325|dbj|BAA91925.1|_6:131 ; 14 gi|7473181|pir||H75504_59:193 ; 15 gi|7657403|ref|NP_054861.1|_8:196 ; 16 gi|6288769|gb|AAF06734.1|AF155832_1_8:196 ; 17 gi|7271817|gb|AAF44630.1|AF222786_1_10:192 ; 18 gi|7573205|emb|CAB87374.1|_15:182 ; 19 gi|6319587|ref|NP_009669.1|YSA1_67:200 ; 20 gi|7508854|pir||T33225_15:197 ; 21 gi|7429372|pir||S74496_17:182 ; 22 gi|7473179|pir||G75449_19:157 ; 23 gi|4099064|gb|AAD00531.1|_13:161 ; 24 gi|7516527|pir||A72628_19:175 ; 25 gi|1731093|sp|P54570|YQKG_BACSU_7:178 ; 26 gi|7445034|pir||H72286_6:169 ; 27 gi|7226303|gb|AAF41460.1|_8:176 ; 28 gi|7379943|emb|CAB84518.1|_8:176 ; 29 gi|7480127|pir||T36878_10:184 ; 30 gi|7446148|pir||C70503_4:175 ; 31 gi|2145862|pir||S72960_3:141 ; 32 gi|2065219|emb|CAB08283.1|_6:145 ; 33 gi|1871177|gb|AAB63537.1|_108:226 ; 34 gi|6498247|dbj|BAA87699.1|_4:123 ; 35 gi|7473167|pir||C75446_6:136 ; 36 gi|7515882|pir||B72646_7:117 ; 37 gi|4220481|gb|AAD12704.1|_53:153 ; 38 gi|7190189|gb|AAF39029.1|_33:134 ; 39 gi|7520006|pir||B75178_19:164 ; 40 gi|7451653|pir||C71036_19:164 ; 41 gi|7451652|pir||A70426_14:119 ; 42 gi|7451649|pir||S75733_14:120 ; 43 gi|7451651|pir||G69041_10:113 ; 44 gi|7451650|pir||A69404_7:120 ; 45 gi|2129134|pir||D64443_34:156 ; 46 gi|7451654|pir||S77438_12:125 ; 47 gi|7480622|pir||T36870_19:134 ; 48 gi|7473169|pir||D75476_16:140 ; 49 gi|7473168|pir||C75476_14:135 ; 50 gi|7473175|pir||F75532_17:140 ; 51 gi|7473180|pir||G75571_3:143 ; 52 gi|7508500|pir||T25296_43:181 ; 53 gi|7299465|gb|AAF54653.1|_60:160 ; 54 gi|7451656|pir||A70315_7:112 ; 55 gi|7475399|pir||E69994_20:85 ; 56 gi|1702995|sp|P53370|GFG_HUMAN_2:85 ; 57 gi|547726|sp|P35640|INVA_BARBA_6:79 ; 58 gi|7473180|pir||G75571_193:313 ; 59 gi|7473175|pir||F75532_188:304 ; 60 gi|7451658|pir||D69663_5:106 ; 61 gi|7473171|pir||E75541_47:152 ; 62 gi|7446153|pir||F69044_7:107 ; 63 gi|7446154|pir||H69029_15:119 ; 64 gi|6524184|gb|AAF15069.1|AC011914_11_10:128 ; 65 gi|2506882|sp|P52006|YFAO_ECOLI_6:123 ; 66 gi|7451657|pir||S76176_9:119 ; 67 gi|1045226|emb|CAA63159.1|_9:119 ; 68 gi|7481084|pir||T34602_12:126 ; 69 gi|7473163|pir||B75284_6:104 ; 70 gi|2641974|dbj|BAA23614.1|_7:116 ; 71 gi|7446157|pir||G70031_10:117 ; 72 gi|1177029|sp|P46351|YTH1_PANTH_245:392 ; 73 gi|7446149|pir||E70951_147:294 ; 74 gi|7444972|pir||T08762_99:226 ; 75 gi|6960340|gb|AAF33500.1|_106:232 ; 76 gi|418527|sp|P32664|YJAD_ECOLI_107:232 ; 77 gi|1176342|sp|P44710|YJAD_HAEIN_117:235 ; 78 gi|3549119|gb|AAC34568.1|_129:256 ; 79 gi|7473174|pir||F75428_118:255 ; 80 gi|7293104|gb|AAF48489.1|_159:287 ; 81 gi|7446156|pir||T06630_102:217 ; 82 gi|4587605|gb|AAD25833.1|AC006951_12_105:216 ; 83 gi|4587607|gb|AAD25835.1|AC006951_14_107:217 ; 84 gi|7479418|pir||T34785_14:139 ; 85 gi|7379568|emb|CAB84133.1|_7:133 ; 86 gi|7225871|gb|AAF41065.1|_7:136 ; 87 gi|7479996|pir||T36468_34:215 ; 88 gi|2506700|sp|P37128|YFFH_ECOLI_3:186 ; 89 gi|505331|gb|AAB46945.1|_3:154 ; 90 T0090 ; 91 gi|1731053|sp|P36651|YQIE_ECOLI_1:209 ; 92 gi|7466060|pir||C58723_3:142 ; 93 gi|1177043|sp|P44684|YQIE_HAEIN_4:214 ; 94 gi|4314286|gb|AAD15563.1|_78:280 ; 95 gi|7497768|pir||T20117_658:831 ; 96 gi|6967918|emb|CAB75085.1|_11:167 ; 97 gi|7301558|gb|AAF56679.1|_1145:1340 ; 98 gi|7301558|gb|AAF56679.1|_941:1140 ; 99 gi|7463977|pir||C64583_8:206 ; 100 gi|7464728|pir||F71928_9:206 ; 101 gi|7473166|pir||C75303_8:187 ; 102 gi|2209125|gb|AAB95442.1|_155:359 ; 103 gi|886310|gb|AAB53126.1|_13:191 ; 104 gi|7473177|pir||F75554_32:188 ; 105 gi|730088|sp|P41354|MUTX_STRPN_5:112 ; 106 gi|3287246|emb|CAA75864.1|_5:110 ; 107 gi|2497998|sp|P95781|MUTX_STRMU_6:116 ; 108 gi|6678950|ref|NP_032663.1|_9:112 ; 109 gi|1703023|sp|P53369|8ODP_RAT_9:112 ; 110 gi|5821385|dbj|BAA83798.1|_49:153 ; 111 gi|5821375|dbj|BAA83793.1|_31:135 ; 112 gi|4505275|ref|NP_002443.1|_9:112 ; 113 gi|1075045|pir||I64101_106:209 ; 114 gi|1171082|sp|P44932|MUTT_HAEIN_8:111 ; 115 gi|4741382|emb|CAB41840.1|_3:108 ; 116 gi|4741384|emb|CAB41841.1|_3:108 ; 117 gi|147795|gb|AAA24620.1|_7:73 ; 118 gi|127558|sp|P08337|MUTT_ECOLI_7:116 ; 119 gi|4741322|emb|CAB41817.1|_3:108 ; 120 gi|4741342|emb|CAB41827.1|_3:97 ; 121 gi|4741344|emb|CAB41828.1|_3:108 ; 122 gi|4741330|emb|CAB41821.1|_3:108 ; 123 gi|4741370|emb|CAB41834.1|_3:108 ; 124 gi|4741326|emb|CAB41819.1|_3:108 ; 125 gi|4741332|emb|CAB41822.1|_3:108 ; 126 gi|4741352|emb|CAB41832.1|_3:108 10 20 30 40 50 | | | | | 1 LTMREERQRNLLAKFQSLTKWASIYRRCPK...CAAALKMRSSKSGAECVTCQRVYYPTF..... 2 KRHEACRLRVFHVQELESVSPRKTVRRFV-...----------------------TLTAP..... 3 ------------------------------...-------------------------TD..... 4 ------------------------------...---------------------------..... 5 ------------------------------...---------------------------..... 6 ------------------------------...-------------------NYQYPRTD..... 7 --------------QWAKQSEQNVYSNRW-...FSVNLADVLLPDGRHL----DHFLIRM..... 8 ------------------------------...--------------------GRWGPNH..... 9 ------------------------------...----------FSNGVRRVYERMRPTNR..... 10 ------------------------------...--------------ASREQMRAQCLRH..... 11 ------------------------------...--------------ARRGDAYARGLRH..... 12 ------------------------------...------------GQILRTDPALRWERV..... 13 ------------------------------...------------------QPRGRRPGV..... 14 ----TNTTATPTPAPPKKRGQKRPAGEPR-...---------------------------..... 15 --------ESSQNGKQYIISEELISEGKWVkleKTTYMDPTGKTRTWESVNVPTRKEQTA..... 16 --------ESSQNGKQYIISEELISEGKWVkleKTTYMDPTGKTRTWESVKRTTRKEQTA..... 17 -----------SPGKHLVTSEELISEGKWVkfeKTTYMDPTGKTRTWETVKLTTRKGKSA..... 18 LENQDAKWTSLKKIRWQDEKGKIRFWEMA-...-----------------ERTTRSEANV..... 19 ------------------------------...----------------AVRTTRSSGGV..... 20 -NKNEEMVATPANCPYQLFNQEVVWNGKW-...IQTRQVGFKTHTGQVGVWQSVHRNTKPveasa 21 ------------------LQQKLFYRGRK-...---FNFDVSRRQLPNGVVGDWELIQHP..... 22 ------------------------------...-----------------EGKWEIVRHA..... 23 ------------------------------...------LVRRAREVGGRIIWGEYLVHP..... 24 ------------------------------...----KFEARMETLPNGRQILVDRVVFP..... 25 ----------------KTIAKEQIFSGKV-...IDLYVEDVELPNGKAS---KREIVKHP..... 26 ----------------EKIDSKRVFEGKM-...ISVRVDRVRLPDGRES---TREVVDHP..... 27 ------------------LGGETIYEGGF-...VSISRDKVRLPNGNEG---QRIVIRHP..... 28 ------------------LGGETIYEGGF-...VSISRDKVRLPNGNEG---QRIVIRHP..... 29 ------------PEEWEIRGSQTPFRGKK-...TSVRTDDVVMPDGS---VVTRDYQVHP..... 30 -------------HDFETISSETLHTGAI-...FALRRDQVRMPGGG---IVTREVVEHF..... 31 ------------------------------...--------------------REVVEQC..... 32 ------------------------------...-------------------AREVVEQC..... 33 ------------------------------...-------------AICTHCGKIAYQNP..... 34 ------------------------------...----------------------IPIRS..... 35 ------------------------------...-------------------RTHVPVEL..... 36 ------------------------------...--------------------------P..... 37 ------------------------------...---------------------------..... 38 ------------------------------...---------------------------..... 39 ------------------------------...VSEFREEVRKIAEGKRLRAELHRCIGL..... 40 ------------------------------...ISGFEKKIKETGKKEGIKVEMYRCIGL..... 41 ------------------------------...---------------------------..... 42 ------------------------------...---------------------------..... 43 ------------------------------...---------------------------..... 44 ------------------------------...---------------------------..... 45 ------------------------------...-------------------KYRLYLH-..... 46 ------------------------------...---------------------LLRRPL..... 47 ------------------------------...---------------------------..... 48 ------------------------------...---------------------HAPVNF..... 49 ------------------------------...-------------------IGHRPVNW..... 50 ------------------------------...--------------------------L..... 51 ------------------------------...--------VMSYLSELRAVWGHRALPA..... 52 -------------------------NGAVA...KKKNEPRVPDMQLGKCRYVRLHDNVNY..... 53 ------------------------------...---------------------------..... 54 ------------------------------...---------------------------..... 55 ------------------------------...---------------------------..... 56 ------------------------------...---------------------------..... 57 ------------------------------...-------------------DFKTLPYR..... 58 ------------------------------...--------------------------I..... 59 ------------------------------...-----------------------LWFM..... 60 ------------------------------...---------------------------..... 61 ------------------------------...---------------------------..... 62 ------------------------------...---------------------------..... 63 ------------------------------...---------------------------..... 64 ------------------------------...---------------------------..... 65 ------------------------------...---------------------------..... 66 ------------------------------...---------------------------..... 67 ------------------------------...---------------------------..... 68 ------------------------------...---------------------------..... 69 ------------------------------...-------------------------PL..... 70 ------------------------------...---------------------------..... 71 ------------------------------...---------------------------..... 72 ------------------------------...--AIIPDLRSLWDEELRIERWIPPAFPwpddi 73 ------------------------------...---PTKPARAGWSRVNPITGHEEFPRI..... 74 ------------------------------...-------NVAGSKRVCPSNNIIYYPQM..... 75 ------------------------------...-----HPSKTEWAMLCSHCRERYYPQI..... 76 ------------------------------...------PSKTEWAMLCSHCRERYYPQI..... 77 ------------------------------...---------------CIHCGYQTYPVI..... 78 ------------------------------...------------VMQCPQCGLHQYPRL..... 79 ------------------------------...--TPMRPGEGDRARRCPSCGLRVYPRV..... 80 ------------------------------...------------------------HTL..... 81 ------------------------------...-------------------------HV..... 82 ------------------------------...---------------------------..... 83 ------------------------------...---------------------------..... 84 ------------------------------...---------------------------..... 85 ------------------------------...-----------------------LKYP..... 86 ------------------------------...-----------------------LKYP..... 87 ------------------RDVELTSQGWHV...LRRTTFDYRRRDGRWE-TQARETYDRG..... 88 -------------QQITLIKDKILSDNYFT...LHNITYDLTRKDGEVIRHK-REVYDRG..... 89 -------------QQITLIKDKILSDNYFT...LHNITYDLTRKDGEVIRHK-REVYDRG..... 90 MLKPDNLPVTFGKNDVEIIARETLYRGFFS...LDLYRFRHRLFNGQMSHEVRREIFERG..... 91 MLKPDNLPVTFGKNDVEIIARETLYRGFFS...LDLYRFRHRLFNGQMSHEVRREIFERG..... 92 ------------------------------...---------------------------..... 93 WRKQMSEIQHFSQQDIEILGEQTLYEGFFT...LKRIQFKHKLFAGGQSGVVTRELLIKG..... 94 --------------------------GRCA...ASPYLRPLTLHYRQNGAQKSWDFMKTH..... 95 ------------------------------...VSKYQKGMEMSYTLDGNSRVSEFNQKM..... 96 ----------------------------FE...KSNYIKPKRFAYESNGRLCTWDFIESK..... 97 ---------------------KIWLGPLPQ...DSPYVKPFRLYYVQNGVEKNWDLLKVH..... 98 --------------------SKIWFGPMPK...DSNWIKPGRLHYIENDVEKQVDIIKTI..... 99 ------------FNQKSLIDDSSVYLEPCS...SSNFIELKRMHYNEENTKKTWDIIKSL..... 100 -------------NQKSLIDDSSVYLEPCS...SSNFIELKRMHYNEENTKKTWDIIKSL..... 101 QHPNWAGLTEDAVTPWKTLSSRQLVGGFR-...-TVYEDRVQVRPGVETTYQYR--PRGP..... 102 --GPARRRHAAQPGDVRIVRRSQPYANFFA...VEEYDLSFRSFGGGMSPTLNRAVFISG..... 103 QAKPRRRRKRRRGRDATRSAENHTDRQVAN...DATATKPRRSHSPHRAPEQLRTVHETS..... 104 -----------NGKSRRARRFSLMVLGGWV...MERAQHNLRFTELARARAYAQAHGLRQ..... 105 ------------------------------...---------------------------..... 106 ------------------------------...---------------------------..... 107 ------------------------------...---------------------------..... 108 ------------------------------...---------------------------..... 109 ------------------------------...---------------------------..... 110 ------------------------------...---------------------------..... 111 ------------------------------...---------------------------..... 112 ------------------------------...---------------------------..... 113 ------------------------------...---------------------------..... 114 ------------------------------...---------------------------..... 115 ------------------------------...---------------------------..... 116 ------------------------------...---------------------------..... 117 ------------------------------...---------------------------..... 118 ------------------------------...---------------------------..... 119 ------------------------------...---------------------------..... 120 ------------------------------...---------------------------..... 121 ------------------------------...---------------------------..... 122 ------------------------------...---------------------------..... 123 ------------------------------...---------------------------..... 124 ------------------------------...---------------------------..... 125 ------------------------------...---------------------------..... 126 ------------------------------...---------------------------..... 60 70 80 90 | | | | 1 .SPVSITLIT....DPT...NE...HALLVRHRGSA-........-----GGVFTAVAGFAhvsd 2 .EWVIVVPHV....MER...AQrf.FVMVRQWRCGS-........----QTVCTEFPGGVI.... 3 .AAVVVPVFD....EKC...PK...IVMIKRSKGLN-........---RSAGHIAFPGGMI.... 4 .---------....-NA...IE...FLLLQASDGIH-........-------HWTPPKGHV.... 5 .---------....---...-E...FLLLQASNGIH-........-------HWTPPKGHV.... 6 .PCVIMVILS....HDM...QH...ILLGRALRHP--........-----KGLYACLAGFL.... 7 .RPVAVATVV....NEA...DE...VLLLWRHRFIT-........----DSWGWELAAGVV.... 8 .AADPIVSRT....NDN...GDle.FVAVQRH-----........----DNGEWAIPGGMV.... 9 .EAVMIVPI-....-VD...DH...LILIREYAVGT-........----ESYELGFSKGLI.... 10 .RATYIVVH-....DGM...GK...ILVQRRTETKD-........--FLPGMLDATAGGVV.... 11 .RCVFVWAR-....DPE...GR...VFVHRRTATKL-........--VFPAPYDMFVGGVV.... 12 .RVVNAFLR-....NSQ...GQ...LWIPRRSPSKS-........--LFPNALDVSVGGAV.... 13 .GVGVVVTSC....KHP...RC...VLLGKRKGSV--........----GAGSFQLPGGHL.... 14 .--IGVGCIV....LRG...EE...ILLVRE------........-----RGRWSLPKGGL.... 15 .DGVAVIPVL....QRTlhyEC...IVLVKQFRPPM-........----GGYCIEFPAGLI.... 16 .DGVAVIPVL....QRTlhyEC...IVLVKQFRPPM-........----GGYCIEFPAGLI.... 17 .DAVSVIPVL....QRTlhhEC...VILVKQFRPPM-........----GSYCLEFPAGFI.... 18 .DAVAILAIV....PID...GSph.VLCQKQFRPPI-........----GKFCIEIPAGLV.... 19 .DGIGILTILkykdGKP...DE...ILLQKQFRPPV-........----EGVCIEMPAGLI.... 20 .DGVSIIARV....RKQ...GKly.IVLVKQYRIPC-........----GKLCLELPAGLI.... 21 .GGALVVPI-....TSE...GQ...LVLVRQYRFAL-........----AGRLLEFPAGTV.... 22 .DAVAILLL-....SEG...GE...MKLVRQRRRAV-........----DADTLEAPAGLI.... 23 .GAVAVLAL-....-TG...GK...AVLVRQFRPAL-........----KSWTIEIPAGTL.... 24 .DSVAVLPLV....EKD...GEwh.VVLVRQFRPSI-........----GKWTLEAPAGTL.... 25 .GAVAVLAV-....TDE...GK...IIMVKQFRKPL-........----ERTIVEIPAGKL.... 26 .GAVVIVPV-....-LG...GK...ILFVEQYRYPI-........----EQVLLELPAGKL.... 27 .GAACVLAV-....TDE...GK...VVLVRQWRYAA-........----NQATLELPAGKL.... 28 .GAACVLAV-....TDE...EK...VVLVRQWRYAA-........----NQATLELPAGKL.... 29 .GSVAVLAL-....DGE...GR...VLVIRQYRHPV-........----REKLWEIPAGLL.... 30 .GAVAIVAM-....DDN...GN...IPMVYQYRHTY-........----GRRLWELPAGLL.... 31 .SVVAIAAM-....-DG...NS...IPMVYRYRNTY-........----DSWLWELPAGLL.... 32 .SVVAIAAM-....-DG...NS...IPMVYRYRNTY-........----DSWLWELPAGLL.... 33 .KMVVGCLI-....EHE...GK...VLLCKRNIQPS-........-----HGLWTLPAGYL.... 34 .FGVSVVLLR....NAK...PEte.VLLLRRNHTLV-........------GEWCQIAGGI.... 35 .RAAGVVLL-....NER...GD...ILLVQEKGIPG-........-HPEKAGLWHIPSGAV.... 36 .DSSVLALLW....GSP...TR...VLLVRKRCAPG-........--SPWACDLALPGGGV.... 37 .---------....---...--...------------........-SSQKGHALMFPKGGW.... 38 .---------....---...--...------------........--HTDGKHWGFPKGHA.... 39 .TVDLVIVY-....--N...NG...IVFIRRKNEPY-........-----KGYLALPGGFV.... 40 .TVDIVIIY-....--N...NG...IVLIRRKNEPY-........-----KGFLALPGGFV.... 41 .--VIIRLWD....GEN...FKg..IVLIERKYPPV-........-------GLALPGGFV.... 42 .----IEMID....QPR...RP...ILLIERQNPPH-........-------GWALPGGFV.... 43 .-----VIIR....LSG...DR...IILIRRGRSPY-........-----RGSWAIPGGFV.... 44 .TVDAIIPY-....--Q...GK...IVLIKRLNEPF-........-----KGHYALPGGIV.... 45 .PAVAVDGII....EKD...NK...ILLIKRKNNPF-........-----KGCFALPGGFV.... 46 .SAVTVIPV-....LSD...SS...IVLVKRR-----........----DTGQWSLPGGLI.... 47 .---AVLTLR....AGA...LH...ALLVERGQEPY-........-----AGRWALPGGFL.... 48 .VGAAGLIC-....NAA...GE...VLLQRRR-----........----GSERWGLVAGIA.... 49 .AGACALVL-....NGA...GE...VLLQRRQ-----........----DTGGWGTPGGIA.... 50 .GVAAGVLIQ....NER...GE...VLLQKRG-----........----DDGLWGEPGGGL.... 51 .AGVSVLLQ-....DET...GR...VLLQRRG-----........----DDGQWGILGGGL.... 52 .VAAAIILRN....QGD...DTe..VLLIQEAKKSC-........-----RGKWYMPAGRV.... 53 .--IVACVLI....NEH...DE...LLMIEEAKQSC-........-----AGKWYLPAGRM.... 54 .--AGGVLF-....-KD...GE...VLLIKTP-----........-----SNVWSFPKGNI.... 55 .------PFS....DSP...KH...VWVICRFGGKWL........LTEHEDRGYEFPGGKV.... 56 .---------....---...--...------------........--------WKFPGGLS.... 57 .KGVGIVVF-....NRE...GQ...VWIGRRLITSSH........TYAEVSKLWQFPQGGI.... 58 .APGANVAVT....NER...GE...VLLLKHAGTGN-........---TVTGKWTLPGGSL.... 59 .PGSSVLVT-....DEA...GR...LLLLRHK-----........----ATDQWTLPGGKL.... 60 .-GAFVIVL-....NES...QQ...ILLVKRKDVP--........-------LWDLPGGRV.... 61 .--VWVVLR-....GAS...GR...VLLARRQGTAY-........----ANGLWGLPGGRV.... 62 .--V-VRALI....RGE...DG...VLMLRRSRES--........--STNPSLWELPGGKV.... 63 .------FIE....DDD...GR...VLLIKRASDSK-........---TNASRWELPGGKI.... 64 .--VAVVVFI....LNG...NS...ILLGRRRSSI--........----GNSTFALPGGHL.... 65 .---IVCPLI....QND...GA...YLLCKMADDRG-........---VFPGQWAISGGGV.... 66 .--TVGALVT....APD...GR...VLIVKTTK----........----WRGTWGVPGGKV.... 67 .-LVVGALIS....DPL...GR...IFVQRRSADRR-........---LFPACWDVVGGAV.... 68 .---VGAVIL....NRE...GR...AFAQKRSRDRR-........---LFPGAWDIVGGHV.... 69 .RPRAVALIY....DDQ...HH...ILLMLRHKNG--........-----KKYATLPGGGI.... 70 .---AIILR-....NEQ...DE...IALIRRDKPN--........-----ETYYVFPGGGK.... 71 .------CVL....QTD...DK...VLLLQKPR----........-----RGWWVAPGGKM.... 72 kPGVAGIVM-....DER...GR...VLLMKRA-----........----DNGCWGLPSGHV.... 73 .DPAVICLVH....DGA...DR...AVLARQAAWP--........-----ERMFSLLAGFV.... 74 .APVAITLV-....SDG...TR...CLLARQSSFP--........-----KGMYSALAGFC.... 75 .APCIIVAI-....RRE...DS...ILLAQHVRHR--........-----NGVHTVLAGFV.... 76 .APCIIVAI-....RRD...DS...ILLAQHTRHR--........-----NGVHTVLAGFV.... 77 .CPSIIVAV-....RRG...HE...ILLANHKRHY--........--SPNGGIYTTLAGFV.... 78 .SPSMIVLV-....TRG...DE...VLLARSPRFV--........-----PGVYSTLAGFV.... 79 .APAIIVLIS....RGT...GPdteFLLLRGPRQA--........-----PDVFTTLAGFV.... 80 .MGVGGLVI-....NEQ...DE...VLVVSDRFAMI-........-----PNSWKLPGGYV.... 81 .VGAGALVIN....KNT...KE...VLVVQERSGFF-........---KDKNVWKLPTGVI.... 82 .-GVGAFVLN....KKT...KE...VLVVQEIDGHF-........---KGTGVWKLPTGVV.... 83 .-GIGAFVL-....NKN...GE...MLVVQENSGYF-........---KDKNVWKVPTGTI.... 84 .RRVARVVLL....DPE...DR...ILLLHGHEPD--........--DPADDWWFTPGGGV.... 85 .VSALVVLY-....SGD...GG...ILLIERTH----........----PKGFWQSVTGSL.... 86 .VSALVVLY-....SGD...GG...ILLIERTH----........----PEGFWQSVTGSL.... 87 .NGAVVLPYD....TGR...GR...VLLTRQFRYPAYv.......NDHPDGMLVEAAAGLL.... 88 .NGATILLYN....TKK...KT...VVLIRQFRVATWv.......NGNESGQLIESCAGLL.... 89 .NGATILLYN....TKK...KT...VVLIRQFRVATWv.......NGNESGQLIESCAGLL.... 90 .HAAVLLPFD....PVR...DE...VVLIEQIRIAAY........DTSETPWLLEMVAGMI.... 91 .HAAVLLPFD....PVR...DE...VVLIEQIRIAAY........DTSETPWLLEMVAGMI.... 92 .---------....---...DE...VVLIEQIRIAAY........DTSETPWLLEMVAGMI.... 93 .AASAVIAYD....PKE...DS...VILVEQVRIGAAyhp.....ESHRSPWLLELIAGMV.... 94 .DSVTVLLFN....SSR...RS...LVLVKQFRPAVYage26qpaLPGSAGVTVELCAGLV.... 95 .SSVSILLFH....RDL...EQ...FLLVRQFRPAIFtas22wssYDSETGYTIELCAGLI.... 96 .DSVSVLLYH....KEL...ES...FIFVRQFRIPLWyhq10dyvKDDDMGYTIELCSGLV.... 97 .DSVAIILYN....TSR...QK...LVLVRQFRPAVYhgi18lkeFPPAIGVTLELCAGIV.... 98 .DGVVVILYN....KAR...EK...LIFVRQFRGAVYqgi20leqFPPEVGVTLELCGGAV.... 99 .DSVAVLLYE....KES...DC...FVIVKQFRPAIYarr10cdqDQTIDGYTYELCAGLV.... 100 .DSVAVLLYE....KES...DC...FVIVKQFRPAIYarn10rdqDQTIDGYTYELCAGLV.... 101 .RAVFILPV-....TAQ...GE...AVLIRQFRYPL-........----RATITEIVAGGV.... 102 .DAVTVVPYD....PVR...DR...VLLIEQFRPGPLg.......RGDAQPWLLEPIAGRV.... 103 .AGGLVIYGI....DGP...RDaqvAALIGRIDRR--........----GRMLWSLPKGHI.... 104 .KAVCHIVR-....--R...GT...ELLVFDHVPD--........----GGAGVQVVAGGL.... 105 .---ATICYI....DNG...KE...LLMLHRNKKPN-........--DVHEGKWIGVGGKL.... 106 .---ATICYI....DNG...KE...LLLLHRNKKEN-........--DVHEGKWISVGGKL.... 107 .----TICYI....DNG...RE...LLLMHRNKKPN-........--DVHEGKWISVGGKL.... 108 .-----LVLV....LQP...QR...VLLGMKKRGF--........----GAGRWNGFGGKV.... 109 .-----LVLV....LQP...QR...VLLGMKKRGF--........----GAGRWNGFGGKV.... 110 .----TLVLV....LQP...QR...VLLGMKKRGF--........----GAGRWNGFGGKV.... 111 .----TLVLV....LQP...QR...VLLGMKKRGF--........----GAGRWNGFGGKV.... 112 .-----LVLV....LQP...QR...VLLGMKKRGF--........----GAGRWNGFGGKV.... 113 .--VAAGIIR....NEF...GQ...IYLTQRLEGQD-........----FAQSLEFPGGKV.... 114 .--VAAGIIR....NEF...GQ...IYLTQRLEGQD-........----FAQSLEFPGGKV.... 115 .-------IR....NEN...NE...IFITRRAADAY-........----MADKLEFPGGKI.... 116 .-------IR....NEN...NE...IFITRRAADAH-........----MANKLEFPGGKI.... 117 .---AVGIIR....NEN...NE...IFITRRAADAH-........----MANKLEFPGGKI.... 118 .---AVGIIR....NEN...NE...IFITRRAADAH-........----MANKLEFPGGKI.... 119 .-------IR....NEN...NE...IFITRRAADAH-........----MANKLEFPGGKI.... 120 .-------IR....NEN...NE...IFITRRAADAH-........----MANKLEFPGGKI.... 121 .-------IR....NEN...NE...IFITRRAADAH-........----MANKLEFPGGKI.... 122 .-------IR....NEN...NE...IFITRRAADAH-........----MANKLEFPGGKI.... 123 .-------IR....NEN...NE...IFITRRAADAH-........----MANKLEFPGGKV.... 124 .-------IR....NEN...NE...IFITRRAADAH-........----MANKLEFPGGKI.... 125 .-------IR....NEN...NE...IFITRRAADAH-........----MANKLEFPGGKI.... 126 .-------IR....NEN...NE...IFITRRAADAH-........----MANKLEFPGGKI.... 100 110 120 130 | | | | 1 lkE.SGESMAECARREIAEEVGI.....EVD....SIRSLD........MS........Q.PWPM 2 ..D.AGEHPEAAARRELFEETGR.....RAS....SLAHLG........TI........H.PNPA 3 ..E.DGENEVEAALREFEEELGI.....NPE....CVDVLG........-F........L.RPRE 4 ..E.PGEDDLETALRETQEEAGI.....EAG....QLTIIE........GF........K.RELN 5 ..E.PGESDLQTALRETQEEAGI.....DAG....QLTIIE........GF........R.KELN 6 ..E.PGESLEEAVVRETYEESGV.....DVE....KVLYYA........SQ........P.WPFP 7 ..E.DGEDVAVAAARELEEETGW.....RPG....PLHHLM........SV........E.PSNG 8 ..D.AGEHVSQTLRREFAEEA--.....---....-MHGIV........DS........E.NLDE 9 ..D.PGESVYEAANRELKEEVGF.....GAN....DLTFLK........KL........S.MAPS 10 ..Q.ADEQLLESARREAEEELGI.....AGV....PFAEHG........QF........Y.FEDK 11 ..G.AGESYDDAALREAEEELGA.....SGLp...RPEFLF........KF........L.YDDG 12 ..Q.SGETYEEAFRREAREELNV.....EIDal..SWRPLA........SF........S.PFQT 13 ..E.FGETWEECAQRETWEEAAL.....HLKnv..HFASVV........NS........F.IEKE 14 ..E.AGELIQDGARRETFEETGL.....VVElr..DLAFIV........EF........Q.AETW 15 ..D.DGETPEAAALRELEEETGY.....KGD....IAECSP........AV........C.MDPG 16 ..D.DGETPEAAALRELEEETGY.....KGD....IAECSP........AV........C.MDPG 17 ..E.DGESPEAAALRELEEETGY.....KGE....VAECSP........AV........C.MDPG 18 ..D.SKESCEDAAIRELREETGY.....VGT....VMDSTT........VM........Y.NDPG 19 ..D.AGEDIDTAALRELKEETGY.....SGK....IISKSP........TV........F.NDPG 20 ..D.AGETAQQAAIRELKEETGY.....VSGk...VVMESK........LC........F.LDPG 21 ..E.VGENPAETVKRELEEEAGY.....RGH....TWQTIG........QF........P.LAPG 22 ..D.EGETPEAAARRELQEEVGL.....DAD....-LTLLT........RF........Y.TSPG 23 ..D.GGESPEEAAVREMIEETGY.....KPL....RLTPLL........DF........Y.PSPG 24 ..K.EGETPEAAAARELEEEAGL.....KAK....ALVRVG........GG........H.VSPG 25 ..E.KGEEPEYTALRELEEETGY.....TAK....KLTKIT........AF........Y.TSPG 26 ..D.PGESPEECAKRELEEETGY.....RAK....KLSYLG........KI........F.TTPG 27 ..DvAGEDMAACALRELAEETPY.....TAD....SVRLLY........SF........Y.TAVG 28 ..DvAGEDMAACALRELAEETPY.....TTD....SVRLLY........SF........Y.TAVG 29 ..DvPGENPLHAAQRELYEEAHV.....KAE....DWRVLT........DV........Y.TTPG 30 ..DvAGEPPHLTAARELREEVGL.....QAS....TWQVLV........DL........D.TAPG 31 ..DaAGEPPYLNTVCGLKEEVGL.....QVS....IWQVLV........DF........N.TAPG 32 ..DaAGEPPYLNTVCGLKEEVGL.....QVS....IWQVLV........DF........N.TAPG 33 ..E.VGESAAQGAMRETWEEAGA.....TVE....VISPFA........--........Q.LDIP 34 ..E.DGEKAWETALREVKEETGL.....GCNrly.SADICE........QF........Y.EADR 35 ..E.DGENPQDAAVREACEETGL.....RVR....PVKFLG........AY........LgRFPD 36 ..K.RGEAPLEAAAREAWEEAWI.....PPA....AVRPLA........SY........C.CEKT 37 ..E.LDESVEEAASRECLEEAGV.....LGN....VEHQLG........--........-.KWDF 38 ..E.EKEGPQEAAERELVEETGLg....IVN....FFPKIF........VE........N.YSFN 39 ..E.YGERVEEAAVREAKEETGL.....DVK....LLRIVG........-V........Y.SDPN 40 ..E.YGEKVEDAAIREAKEETGL.....DVK....LLRIVG........-V........Y.SDPR 41 ..E.VGERVEEAAAREMREETGL.....EVR....-LHKLM........GV........Y.SDPE 42 ..D.YGETLEAAALREAKEEISL.....DVQ....LIEMFY........-A........Y.SDPR 43 ..E.YGETVEDAARREALEETGL.....DVE....IKDLLG........-V........Y.SDPR 44 ..E.YGERVEDAVLREVEEETGL.....KGE....-IHSLV........GV........Y.SDPN 45 ..E.CGETVEEAVVREIKEETGL.....IPK....-VKSLL........GV........Y.SSPD 46 ..D.WGETVAITAARELQEETGL.....RLI....KIDRLL........GV........Y.SSPD 47 ..L.PAESAEEAARRELAEETGL.....ADV....TGLHLE........QLrt......Y.SEPG 48 ..E.LGEPLEQTLRREVQEELGL.....TVQ....AAEFLE........LLnpag....L.SRVA 49 ..E.LGEALEDTLRRELQEETGL.....RPL....EVQLLT........VVsgaet...H.VQLP 50 ..D.PGEAFLAAAQRELKEETGL.....ECG....NLTWLGvhd9tsgpDL........Y.TRYP 51 ..E.PGEDFLIAAHRELLEETGL.....RCP....NLRPLPlse9vsgpQF........W.HRYP 52 ..E.AGETIEEAVVREVKEETGY.....SCD....VVELLS........--........-.LQVQ 53 ..E.RGESITEAAAREVFEETGL.....NAE....LTTLLA........--........-.VEAA 54 ..E.PGEKPEETAVREVWEETGV.....KGE....ILDYIG........EI........H.YWYT 55 ..E.PMECAEEAALREVKEETGA.....RVK....SLKYLG........Q-........-.---- 56 ..E.PGEDIGDTAVREVFEETGV.....KSEfr..SLLSIR........QQ........H.RSPG 57 ..D.EGEEPLDAARRELYEETGM.....RSV....NL----........--........-.---- 58 ..E.PGESFAECAARELHEETGL.....RAS....RLVPVE........LFagaeyrftS.LNGD 59 ..E.PGESFEECAARELLEETGL.....RAR....RLERLHllagpel.RF........Q.QQGQ 60 ..D.PGESAEEAAVREILEETGY.....NAA....LSAKIG........VY........Q.RPKF 61 ..E.SGETLQDAARREVREEIGV.....EVT....GLGVFG........VS........R.FEAQ 62 ..R.AGETLDEALSREVREETGL.....RIT....PLHLLG........AY........E.QVFP 63 ..G.TGESLEEALKREVKEETNL.....EII....PEEVMG........VV........E.QKFP 64 ..E.FGESFEECAAREVMEETGL.....KIE....KMKLLTvtnn....VF........K.EAPT 65 ..E.PGERIEEALRREIREELGE.....QLL....LTEITPwtfsddi.--rtk.....T.YADG 66 ..E.WGETLEAALKREFQEEVGL.....DLR....EIKFAL........VQ........EaVNDE 67 ..E.DGETHHEALAREIAEETGW.....RLRr...VLARVV........HE........S.WTAD 68 ..E.EGETLLEALAREVEEETGW.....RLT....RVRRFL........GT........T.TWTG 69 ..E.EGETPQGACAREVLEEVNL.....TVQ....VGEQVL........EL........D.NLHG 70 ..D.DGESLEETAIREAHEELGI.....DVE....-LTGIA........AI........V.RFNG 71 ..E.SGESVRDSVIREYREETGI.....YIInp..QLKGVF........TF........I.IKDG 72 ..E.RGESVEEAIVREIREETGL.....QVE....VMRLVGlysdpe..SQ........V.FTYP 73 ..E.AGESFEVCVAREIREEIGL.....TVR....DVRYLG........SQ........Q.WPFP 74 ..D.IGESVEETIRREVAEEVGL.....EVE....SLQYYA........SQ........H.WPFP 75 ..E.VGETLEQAVAREVMEESGI.....KVK....NLRYVT........SQ........P.WPFP 76 ..E.VGETLEQAVAREVMEESGI.....KVK....NLRYVT........SQ........P.WPFP 77 ..E.VGETFEQAVQREVFEETGI.....SIK....NLRYFG........SQ........P.WAFP 78 ..E.AGESVEQCVVREVREEVGV.....EVA....NLEYIG........SQ........N.WPFP 79 ..E.PSETLEAAVHREVGEEVGV.....KVR....QVQYRF........SQ........P.WPFP 80 ..E.PRENLIDAAIREVAEETGI.....RTE....-FRSVV........SL........R.HAHG 81 ..N.EGEDIWTGVAREVEEETGI.....IAD....FVEVLA........FR........Q.SHKA 82 ..K.EGENIWEGALREVEEETGI.....KTK....FVEVLA........FR........E.SHQA 83 ..K.EGESIWAGAVREVKEETDI.....DAE....FVEVLS........FM........E.SHQA 84 ..E.GDETRAEAARRELLEETGIt....DVElgpvLWRRRC........SF........P.FAGR 85 ..E.PGETVAQTARREVWEETGIlladgQLQ....DWHDST........VYeiyhhwrhR.YPKG 86 ..E.PGETVAQTARREVWEETGIlladgQLQ....DWHDST........VYeiyhhwrhR.YPKG 87 ..D.ADDAP-AAVRREAAEELGV.....ALG....PLTHVL........DA........Y.MSPG 88 ..D.NDE-PEVCIRKEAIEETGY.....EVG....EVRKLF........EL........Y.MSPG 89 ..D.NDE-PEVCIRKEAIEETGY.....EVG....EVRKLF........EL........Y.MSPG 90 ..E.EGESVEDVARREAIEEAGL.....IVK....RTKPVL........SF........L.ASPG 91 ..E.EGESVEDVARREAIEEAGL.....IVK....RTKPVL........SF........L.ASPG 92 ..E.EGESVEDVARREAIEEAGL.....IVK....RTKPVL........SF........L.ASPG 93 ..E.KGEKPEDVALRESEEEAGI.....QVK....NLTHCL........SV........W.DSPG 94 ..DqPGLSLEEVACKEAWEECGY.....HLAps..DLRRVA........TY........W.SGVG 95 ..DkEGLSPREIASEEVAEECGY.....RVDpd..DLIHVI........TF........V.VGAH 96 ..D.KKLSLEEIAKEECIEELGY.....APK....NLEKIG........DF........Y.TGFG 97 ..D.KNKSWVEIAREEVVEECGY.....DVPve..RIEEVM........VY........R.SGVG 98 ..D.KDKSLAEIAKEEVLEECGY.....EVPte..SLQHVY........DY........R.SGIG 99 ..DkANKSLEEIACEEALEECGY.....QISpk..NLETIG........QF........Y.SATG 100 ..DkANKSLEEIACEEALEECGY.....QISpk..NLETIG........QF........Y.SATG 101 ..E.KGEDLGAAAARELLEEVGG.....AAS....EWVPLP........GF........Y.PQPS 102 ..D.PGETPEAAARREAVEEAGL.....DLG....ALLPVA........SY........Y.PTPA 103 ..E.QGETAEQTAIREVAEETGI.....RGS....VLAALG........QI........D.YWFV 104 ..E.AGETPEQAALREAGEETGQ.....DGFq...VVGFLG........SAv.......W.LNTE 105 ..E.RGETPQECAVREILEETGL.....KAKp...VLKGVI........TF........P.EFTP 106 ..E.AGETPDECAKREILEETHL.....TEKkm..DFKGVI........TF........P.EFTP 107 ..E.KGESPDECARREIFEETHL.....IVKqm..DFKGII........TF........P.DFTP 108 ..Q.EGETIEDGAKRELLEESGL.....SVD....TLHKVG........HI........S.FEFV 109 ..Q.EGETIEDGAKRELLEESGL.....RVD....TLHKVG........HI........S.FEFV 110 ..Q.EGETIEDGARRELQEESGL.....TVD....ALHKVG........QI........V.FEFV 111 ..Q.EGETIEDGARRELQEESGL.....TVD....ALHKVG........QI........V.FEFV 112 ..Q.EGETIEDGARRELQEESGL.....TVD....ALHKVG........QI........V.FEFV 113 ..D.AGETPEQALKRELEEEIGI.....VAL....NAELYE........RF........Q.FEYP 114 ..D.AGETPEQALKRELEEEIGI.....VAL....NAELYE........RF........Q.FEYP 115 ..E.MGETPEQAVVRELQEEVGI.....TPQ....HFSLFE........KL........E.YEFP 116 ..E.MGETPEQAVVRELQEEVGI.....TPQ....HFSLFE........KL........E.YEFP 117 ..E.MGETPEQAVVRELQEEVGI.....TPQ....HFSLFE........KL........E.Y--- 118 ..E.MGETPEQAVVRELQEEVGI.....TPQ....HFSLFE........KL........E.YEFP 119 ..E.MGETPEQAVVRELQEEVGI.....TPQ....HFSLFE........KL........E.YEFP 120 ..E.MGETPEQAVVRELQEEVGI.....TPQ....HFSLFE........KL........E.YEFP 121 ..E.MGETPEQAVVRELQEEVGI.....TPQ....HFSLFE........KL........E.YEFP 122 ..E.MGETPEQAVVRELQEEVGI.....TPQ....HFSLFE........KL........E.YEFT 123 ..E.MGETPEQAVVRELQEEVGI.....TPQ....HFSLFE........KL........E.YEFP 124 ..E.MGETPEQAVVRELQEEVGI.....TPQ....HFSLFE........KL........E.YEFP 125 ..E.MGETPEQAVVRELQEEVGI.....TPQ....HFSLFE........KL........E.YEFP 126 ..E.MGETPEQAVVRELQEEVGI.....TPQ....HFSLFE........KL........E.YEFP 140 150 160 170 180 1 | | | | | 1 PDS...SLMIAHVAVA..KI..DQKIS..V.---.-CPDELET.AQWFTRHQVKEA--------- 2 VLE...NRVHIFSAEC..TP..EVREP..Q.---.LDTDEFLE.RCVLPVHDVYERMGRAPFDHA 3 VHE...YRIMICPVV-..--..GMIRT..L.DFV.PDGREVSR.VLVDELRKVLKSRRITDWGPN 4 YVA...RNKPKTVIYW..LA..EVKDY..D.VEI.RLSHEHQA.YRWLGLEEACQLAQFKEMKA- 5 YVA...WEKPKTVIYW..LA..EVKDY..D.VEV.RLSREHQA.YRWLGLDEACQLAQFKDM--- 6 QSL...MLACFGIARK..NA..KIQRD..K.---.--DLELED.VRFFSREEVLRSLEWDAKDGP 7 LTD...ARHHVYWAE-..-E..GTYVG..H.--P.VDDFESER.REWVPLKLVPDLVARGEVPAA 8 LWN...NGKELYRGYV..DD..PRNT-..-.---.--DNAWME.TVVFNFHDSKGLLKNVALQAG 9 YFS...SKMNIVVAQD..LY..PESLE..G.---.-DEPEPLP.QVRWPLAHMMDLLEDPDFNEA 10 NCR...VWGALFSCVS..HG..PFAL-..-.---.-QEDEVSE.VCWLTPEEITARCDEFTPDSL 11 AGR...TWWSAVYEVR..VA..GAVSP..Q.VE-.----EVAW.HGF------------------ 12 TLS...SFMCVYELRS..DA..TPIFN..P.---.---NDISG.GEWLTPEHLLARIAAGEAAKG 13 NYH...YVTILMKGEV..DV..THDSE..P.KNV.EPE-KNES.WEWVPWEELPPL--------- 14 GHH...-LQFFYTGRE..VS..GTLQP..R.---.DPDRDVQE.ARFIPIRQLREFIRF------ 15 LSN...CTIHIVTVTI..NG..DDAENarP.KPK.PGDGEFVE.VISLPKNDLLQRLDALVAEEH 16 LSN...CTIHIVTVTI..NG..DDAENarP.KPK.PGDGEFVE.VISLPKNDLLQRLDALVAEEH 17 LSN...CTTHVVTVTI..NG..DDAGNvrP.KPK.PGDGEFME.VISLPKNDLLTRLDALGAEQH 18 LTN...ANLKIILADI..DMskPENQN..P.QQQ.LDDGEYIE.NFPIKLSSLQEELFSLEKKG- 19 FTN...TNLCLVTVEV..DM..SLPENqkP.VTQ.LEDNEFIE.CFSVELHKFPDE--------- 20 LTD...DSQCLVVVDVdgDA..PENQN..P.VQV.LDSTESIE.VLLVEQSALMAYV-------- 21 YSD...EIIYAYLATD..LE..KLPNP..P.--A.QDEDEDIE.VALMTFDQFETAIAKGEMIDA 22 FCD...EQLYVFEAKN..PR..ESRLP..L.---.-DEDEEIE.EVWMAPQTLLDGLRGGTVQSS 23 ISN...ELIRIFYADE..LE..YVGIG..R.--R.DPGEIDME.VLLKEPGEVLRAIISGEVKDS 24 YST...EYIHLFLAYS..LE..KGEMS..P.---.-EEHEVIEgVVEMRLSEALESIESGVIEDL 25 FAD...EIVHVFLAEE..LS..VLEEK..R.--E.LDEDEFVE.VMEVTLEDALKLVESREVYDA 26 FTT...EVIHIFAAED..LE..KTSQN..T.---.-DPDEFIE.VKEVPIEEALSLLKNAEIEDS 27 FCN...EKMYLFEAE-..--..GVRLG..S.TLA.NDEDEITE.TVLMSKEEVRQALANDEIKDG 28 FCN...EKMYLFEAE-..--..GVRLG..S.TLA.NDEDEITE.TVLMSKEEVRQALANDEIKDG 29 GCD...EAVRIFLARD..LS..EAAGE..R.FEV.EDEEADME.LARVPVADLVRGVLAGELHNN 30 FSD...ESVRVYLATG..LR..EVGRP..E.--A.HHEEADMT.MGWYPIAEAARRVLRGEIVNS 31 LSD...ESVRIYLATG..LS..EVARP..E.-AH.DDEEADMT.MLRPPIDETVRRVFSGEIVNF 32 LSD...ESVRIYLATG..LS..EVARP..E.-AH.DDEEADMT.MLRPPIDETVRRVFSGEIVNF 33 LIG...QTYVIFLAKL..K-..-----..N.LHF.APGPESLE.CRLFALDEIP----------- 34 DAI...SMFPVFVGFV..DA..EAAVT..I.---.--NHEHSE.FRWVSFAAALTM--------- 35 GVL...ILRHVWLAEP..EP..GQTLA..P.---.AFTDEIAE.ASFVSREDFAQLYAAGQI--- 36 LTA...GRRIHVVIAA..LQ..GPAEP..R.---.PAEEEVDA.AIWAPL--------------- 37 LSK...SRGTYYEGLM..FP..MLVTE..Q.LEL.WPEQHVRQ.RIWMNVTEAREACRDWWMKEA 38 NKE...EVFVRKEVTY..FL..AEVKG..E.-VH.ADPDEICD.VQWLSLQEGLRLLNFPEIRN- 39 RDP...RGHTVTIAF-..--..-LAVG..S.GEL.KAGDDAKD.VTVIPIEKIEEVKDKLAFDHA 40 RDP...RGHTVTVAF-..--..-LAVG..S.GEL.KAGDDAKD.VTVVPINEIERIKEKLAFDHA 41 RDP...RAHVVSVVWI..GD..AQGEP..K.---.-AGSDAKK.VKVYRLEEIP----------- 42 RDP...RQHTLSVVFL..AA..ATGKP..Q.---.-AADDAKT.VGFFDLWEFPDPVC------- 43 RDP...RGHTVSVCFT..AR..VVSGE..-.--P.EAGSDAAD.IGIFHIEDI------------ 44 RDP...RGHFVSVCFV..VL..PK---..G.GEL.KAGSDAKE.VGLFSLNELPKLAFDHE---- 45 RDP...RGHVISIVFI..L-..DVIGG..E.--L.KAGDDAKE.AEFFDLNNLPKLAFDH----- 46 RDP...RMHSVTISLV..VK..AQ--G..D.LLI.GDRQEISE.VKAFAVEDLP----------- 47 RDP...RMRVVSVAFAa.--..-LLPD..P.PEP.HGGGDAAE.ARWVPYDKAQGLAFD------ 48 NGD...EFYSYTALYR..V-..-TAWT..G.IPV.PDGVEIAE.ARFFSLAEFPPLTRLGQ---- 49 NGD...EFYQVTAVYV..VS..GWEGK..P.--A.PDGAEGTE.LRFFPLDALPA---------- 50 NGH...ELYLVGTLFHgtLP..ADALA..H.AQP.DDSGETLE.LRWCALDDLPP---------- 51 NGD...EVYLVGLRTEgtVP..AAALT..D.ACP.DDGGETLE.LRWFALDDLPP---------- 52 GSG...WYRYAFYCNI..TG..GDLKT..E.---.-PDQESLA.AEWYNIKDL------------ 53 GGS...WFRFVLTGRI..TG..GRLKT..P.--A.DADAESIQ.ARWV----------------- 54 LKG...ERIFKTVKYY..LM..KYKEG..E.--P.RPSWEVKD.AKFFPIKEAKKL--------- 55 ---...----------..--..-----..-.---.--------.--------------------- 56 RFG...-MSDMYLICR..LQ..PRSFT..I.--N.FCQQECLK.CEWMDLESL------------ 57 ---...----------..--..-----..-.---.--------.--------------------- 58 VID...NISVLFRAED..VQ..GELA-..-.---.LDTAESHG.AAWFAPDALPP---------- 59 TWD...SLGLLLRASD..VS..GELRP..P.---.--AGELSE.ARYFAPDELPG---------- 60 QD-...-EQHLFFGSI..TG..GQAM-..-.---.ADGTETAG.LKWVSPGRLP----------- 61 GQP...GVAFLFLAEQ..WQ..GEPTP..L.---.---DLTSE.VGWFTLDSLP----------- 62 HKV...SVNIIFSVEV..RG..GALE-..-.---.-LSMEHED.FCWF----------------- 63 VIN...AAHIIIRCRA..EG..SVKLS..H.---.----EHEG.FAWVEPSDLRRY--------- 64 PSH...YVSVSIRAVL..VD..PSQEP..K.--N.MEPEKCEG.WDWYDWENLPKPLFW------ 65 RKE...EIYMIYLIFD..CV..SANRE..V.KI-.--NEEFQD.YAWVKPEDLV----------- 66 QFH...CPAHFVLLNY..YA..RCEST..Q.--V.IPNEEIVE.WEWVTPLEALDF--------- 67 GVR...HLESDYVVEV..DG..DLSSP..T.---.LERDKHPE.FAWVGPQD------------- 68 DDGgglRHEADYLVEV..DG..DLDHP..R.---.LEWSKHSA.YDWFGPGDLTRL--------- 69 ANP...SHEHYFRCRV..VS..GEMRL..G.---.-DGPEG--.--------------------- 70 FDN...PYFWAKTIGG..QF..GTGTG..E.-EF.EEEGSGYT.PVWIKRSELPSLP-------- 71 DHI...VSEWMMFTFV..AD..S---Y..T.GQN.VSESEEGK.LQWHDVNDIQNLPM------- 72 DGA...ATQFVTACFR..CE..TV--G..G.ALV.RTGAETLD.VNYFEAERLPDPI-------- 73 RS-...-LMVGFHALG..DP..DEEFS..F.---.-SDGEIAE.AAWFTRDEVRAALAAGDWSSA 74 -SG...SLMIACHATV..KP..GQTEI..Q.---.VNLRELET.AAWFSHDEVA----------- 75 QS-...-LMTAFMAEY..DS..GEIV-..-.---.IDPKELLE.ANWYRYDDLP----------- 76 QS-...-LMTAFMAEY..DS..GDIV-..-.---.IDPKELLE.ANWYRYDDLP----------- 77 NS-...-QMVGFLADY..ES..GEIT-..-.---.LQESEIHD.AQWFSYDQP------------ 78 HS-...-LMLGFHAEY..VS..GEIVP..Q.---.--EDEIED.AQWFSLDALPPLPAQRSI--- 79 HS-...-LMLAFTAEY..AG..GDIVP..Q.---.--PGEVEE.AQWFTVSDLPQLPP------- 80 GTF...GCSDMYVVIA..LK..PLNLD..F.--T.RCEREIAR.IQWMPIAEYLKHPQVHETNRQ 81 ILK...KKTDMFFLCV..LS..PRSYD..I.--T.EQKSEILQ.AKWMPIQEYV----------- 82 FLE...IKTDIFFLCE..LE..PTTFE..I.--K.KQDSEILA.AKWMPIEEY------------ 83 VWQ...RKTDIFFVCE..LE..ARTFE..I.--Q.KQDSEIHA.AKWMPVEEY------------ 84 RWD...QDEWYYLARTarTA..TEAVG..P.GLTeLERRSVAG.ARWWTCEELTRA--------- 85 VFE...NREHLFSAEI..PR..DTPI-..-.--V.LQPEEHVS.YGWFDMEEAAEKV-------- 86 VFE...NREHLFSAEI..PR..DTPIA..L.---.-QPEEHVS.YGWFDMEEAAEKVFSP----- 87 SVT...ERLHFFAAPY..TP..ADRTGt.G.GGV.EEEGEDIE.VLEMPFTEALAMTRDGRIADG 88 GVT...ELIHFFIAEY..SD..NQRAN..A.GGG.VED-EDIE.VLELPFSQALEMIKTGEIRDG 89 GVT...ELIHFFIAEY..SD..NQRAN..A.GGG.VED-EDIE.--------------------- 90 GTS...ERSSIMVGEV..DA..TTASG..I.HGL.ADENEDIR.VHVVSREQAYQWVEEGKIDNA 91 GTS...ERSSIMVGEV..DA..TTASG..I.HGL.ADENEDIR.VHVVSREQAYQWVEEGKIDNA 92 GTS...ERSSIMVGEV..DA..TTASG..I.HGL.ADENEDIR.VHVVSREQAYQWVEEGKIDNA 93 GIV...ERIHLFAGEV..DS..AQAKG..I.HGL.AEENEDIK.VHVVKREQAYQWMCEGKIDNG 94 LTG...SRQTMFYTEV..TD..AQRSG..PgGGL.VEEGELIE.VVHLPLEGAQAFADDPDIPKT 95 QSG...SAQHLYYAEI..DE..SMKISe.G.GGN.VHEGEVIT.KVYYPVNVARE---------- 96 SGV...SKQSFYFVEV..DE..KDKIS..S.GGG.VDD-EEIE.AVYVKVQDF------------ 97 SSG...AKQTMYYCEV..TD..ADKAT..G.GGG.VDD-EIIE.VVELSLEEAKRMIQQGAVNNS 98 TSS...SAMSLFYCEV..CD..AQKVS..A.GGG.IGE-ERIQ.VLEMSLEESRQLVQTGATTNG 99 LSG...SLQTLYYAEV..HK..NLKVS..K.GGG.IDT-ERIE.VLFLERSKALDFIMDFQYAKT 100 LSG...SLQTLYYAEA..HE..GLKVS..K.GGG.IDT-EKIE.VLFLERSKALDFIMDFQYAKT 101 ISG...VVFYPLLAL-..--..GVTLG..A.AQL.EDT-ETIE.RVVLPLAEVYRMLEAGEIQDG 102 DKA...EYLYSYVALAq.LD..DGIEG..I.FGM.EGEGEDIR.GHLMSFDEMMALIRSGEICNG 103 TDD...CRVHKTVHHY..LM..-RFSG..G.ELS.DDDLEVTE.VAWVPIRELPSRLAYA----- 104 HAK...RELRHFVHLT..AP..DDLPD..T.WQH.CADGHLFS.FRWEPLHS------------- 105 DLD...WYTYVFKVTE..FE..GDLID..C.---.---NEGM-.LEWVPYDEVL----------- 106 GHD...WYTYVFKVTD..YE..GELIS..D.---.-DESREGT.LEWV----------------- 107 GHD...WYTYVFKVRD..FE..GRLIS..D.---.-KDSREGT.LEWVPYNQVL----------- 108 GSP...ELMDVHIFSA..D-..----H..V.HGT.PTESEEMR.PQWFQLDQIP----------- 109 GSP...ELMDVHIFST..D-..----H..V.HGT.PTESEEMR.PQWFQLDQIP----------- 110 GEP...ELMDMHVFCT..D-..----S..I.QGT.PVESDEMR.PCWFQLDQIP----------- 111 GEP...ELMDVHVFCT..D-..----S..I.QGT.PVESDEMR.PCWFQLDQIP----------- 112 GEP...ELMDVHVFCT..D-..----S..I.QGT.PVESDEMR.PCWFQLDQIP----------- 113 TKI...ISFFFYLVNE..WI..GEPFG..R.---.----EGQE.GFWVEQHA------------- 114 TKI...ISFFFYLVNE..WI..GEPFG..R.---.----EGQE.GFWVEQHA------------- 115 DRH...ITLWFWLVES..WE..GEPWG..K.EG-.-QPGEWMS.LVGLNADDFP----------- 116 DRH...ITLWFWLVER..WE..GKPWG..K.EG-.-QPGEWMA.LVDLNADDFP----------- 117 ---...----------..--..-----..-.---.--------.--------------------- 118 DRH...ITLWFWLVER..WE..GEPWG..K.EG-.-QPGEWMS.LVGLNADDFP----------- 119 DRH...ITLWFWLVER..WE..GEPWG..K.EG-.-QPGEWMS.LVGLNADDFP----------- 120 DRH...ITLWFWLVER..WE..GEPWG..K.EG-.-QPGEWM-.--------------------- 121 DRH...ITLWFWLVER..WE..GEPWG..K.EG-.-QPGEWMS.LVGLNADEFP----------- 122 DRH...ITLWFWLVER..WE..GEPWG..K.EG-.-QPGEWMA.LVGLNADDFP----------- 123 DRH...ITLWFWLVES..WE..GEPWG..K.EG-.-QPGEWMS.LVGLNADDFP----------- 124 DRH...ITLWFWLVES..WE..GEPWG..K.EG-.-QPGEWMS.LVGLNADDFP----------- 125 DRH...ITLWFWLVES..WE..GEPWG..K.EG-.-QPGKWMS.LVGLNADDFP----------- 126 DRH...ITLWFWLVES..WE..GEPWG..K.EG-.-QPGKWMS.LVGLNADEFP----------- 90 200 | | 1 --------------------- 2 LM------------------- 3 FECAGQLVWGASSRVLDD--- 4 --------------------- 5 --------------------- 6 APILF---------------- 7 NMAAALLLL------------ 8 DDAKALRWIAVN--------- 9 RNVSALFL------------- 10 KALALWMKRNAKNEAVETETA 11 --------------------- 12 --------------------- 13 --------------------- 14 --------------------- 15 LTVDAR--------------- 16 LTVDAR--------------- 17 LTV------------------ 18 --------------------- 19 --------------------- 20 --------------------- 21 KSIASYFW------------- 22 SPTVAAALY------------ 23 KTIIAF--------------- 24 KTIALVMAA------------ 25 KTAYAIQYLQLK--------- 26 KTICALT-------------- 27 KTLIGLQYWLM---------- 28 KTLIGLQYWLM---------- 29 CLVVGVLA------------- 30 IAIAGVLA------------- 31 IAIVGILA------------- 32 IAIVGILA------------- 33 --------------------- 34 --------------------- 35 --------------------- 36 --------------------- 37 --------------------- 38 --------------------- 39 KI------------------- 40 KI------------------- 41 --------------------- 42 --------------------- 43 --------------------- 44 --------------------- 45 --------------------- 46 --------------------- 47 --------------------- 48 --------------------- 49 --------------------- 50 --------------------- 51 --------------------- 52 --------------------- 53 --------------------- 54 --------------------- 55 --------------------- 56 --------------------- 57 --------------------- 58 --------------------- 59 --------------------- 60 --------------------- 61 --------------------- 62 --------------------- 63 --------------------- 64 --------------------- 65 --------------------- 66 --------------------- 67 --------------------- 68 --------------------- 69 --------------------- 70 --------------------- 71 --------------------- 72 --------------------- 73 SESKLL--------------- 74 --------------------- 75 --------------------- 76 --------------------- 77 --------------------- 78 --------------------- 79 --------------------- 80 FVCTF---------------- 81 --------------------- 82 --------------------- 83 --------------------- 84 --------------------- 85 --------------------- 86 --------------------- 87 KTILLLQWAALH--------- 88 KTVLLLNYLQT---------- 89 --------------------- 90 ASVIALQWLQLHHQALKNEWA 91 ASVIALQWLQLHHQALKNEWA 92 ASVIALQWLQLHHQALKNEWA 93 IAVIGLQWLQLNYAQLQQSW- 94 LGVIFGVSWFL---------- 95 --------------------- 96 --------------------- 97 PPSCLMGLMW----------- 98 GPSCLLGLLCM---------- 99 TGLSLAILWHL---------- 100 TGLSLAILWHL---------- 101 PSSLTL--------------- 102 PLLLTALWLDRERPRLR---- 103 --------------------- 104 --------------------- 105 --------------------- 106 --------------------- 107 --------------------- 108 --------------------- 109 --------------------- 110 --------------------- 111 --------------------- 112 --------------------- 113 --------------------- 114 --------------------- 115 --------------------- 116 --------------------- 117 --------------------- 118 --------------------- 119 --------------------- 120 --------------------- 121 --------------------- 122 --------------------- 123 --------------------- 124 --------------------- 125 --------------------- 126 ---------------------