; SAM: prettyalign v3.1b (February 24, 1999) compiled 04/18/00_11:44:15 ; (c) 1992-1999 Regents of the University of California, Santa Cruz ; ; Sequence Alignment and Modeling Software System ; http://www.cse.ucsc.edu/research/compbio/sam.html ; ; ------ Citations (HMMs, SAM) ------ ; A. Krogh et al., Hidden Markov models in computational biology: ; ------------- Citations (SAM, SAM-T99, HMMs) ----------------- ; R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: ; Extension and analysis of the basic method, CABIOS 12:95-107, 1996. ; K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting ; remote protein homologies, Bioinformatics 14(10):846-856, 1999. ; A. Krogh et al., Hidden Markov models in computational biology: ; Applications to protein modeling, JMB 235:1501-1531, Feb 1994. ; -------------------------------------------------------------- ; Sequence numbers correspond to the following labels: ; 1 gi|3850197|gb|AAC72001.1|_6:376 ; 2 gi|3850199|gb|AAC72002.1|_6:376 ; 3 gi|5738968|dbj|BAA83426.1|_32:340 ; 4 gi|3323502|gb|AAC26629.1|_6:376 ; 5 gi|436763|dbj|BAA02189.1|_16:292 ; 6 gi|7441860|pir||T07620_1:197 ; 7 gi|1084481|pir||S48023_1:148 ; 8 gi|295365|gb|AAA30206.1|_10:201 ; 9 gi|1808585|emb|CAA67132.1|_3:158 ; 10 gi|2827905|gb|AAB99911.1|_7:379 ; 11 gi|2529289|gb|AAB95297.1|_7:379 ; 12 gi|2706556|emb|CAA78755.1|_1:220 ; 13 gi|345402|pir||A44261_9:202 ; 14 gi|3004463|emb|CAA04673.1|_5:376 ; 15 gi|1708306|sp|Q10265|HS71_SCHPO_5:374 ; 16 gi|1945628|emb|CAA72797.1|_5:371 ; 17 gi|1230567|gb|AAC05418.1|_5:377 ; 18 gi|4164594|gb|AAD05564.1|_13:262 ; 19 gi|2253225|gb|AAB62884.1|_3:203 ; 20 gi|2039364|gb|AAB53051.1|_5:375 ; 21 gi|7503381|pir||T22169_7:375 ; 22 gi|7495875|pir||T19211_6:375 ; 23 gi|1708633|gb|AAB38076.1|_30:404 ; 24 gi|1929868|gb|AAB58248.1|_32:405 ; 25 gi|7579069|gb|AAF64243.1|AF252299_1_3:229 ; 26 gi|6322426|ref|NP_012500.1|KAR2_46:419 ; 27 gi|7494626|pir||T34037_26:400 ; 28 gi|3426021|dbj|BAA32395.1|_29:401 ; 29 gi|121567|sp|P11021|GR78_HUMAN_25:398 ; 30 gi|4033392|sp|Q90593|GR78_CHICK_23:397 ; 31 gi|2598562|emb|CAA05361.1|_26:400 ; 32 gi|6470150|gb|AAF13605.1|AF188611_1_7:381 ; 33 gi|6900104|emb|CAB71335.1|_25:399 ; 34 gi|2506545|sp|P20029|GR78_MOUSE_26:400 ; 35 gi|121570|sp|P07823|GR78_MESAU_25:399 ; 36 gi|121574|sp|P06761|GR78_RAT_25:399 ; 37 gi|109893|pir||A37048_26:400 ; 38 gi|311895|emb|CAA48873.1|_28:396 ; 39 gi|1236795|gb|AAA93010.1|_6:264 ; 40 gi|3510734|gb|AAC33583.1|_10:362 ; 41 gi|2921217|gb|AAC05357.1|_34:344 ; 42 gi|1854597|gb|AAB48219.1|_9:215 ; 43 gi|1854603|gb|AAB48222.1|_9:214 ; 44 gi|1854613|gb|AAB48227.1|_9:215 ; 45 gi|1628635|gb|AAB17395.1|_4:216 ; 46 gi|2829291|gb|AAC00520.1|_15:259 ; 47 gi|3122010|sp|P94317|DNAK_BRAJA_4:371 ; 48 gi|300265|gb|AAB26551.1|_20:325 ; 49 gi|585273|sp|Q08276|HS7M_SOLTU_56:426 ; 50 gi|2661598|emb|CAA15711.1|_18:406 ; 51 gi|7462820|pir||A72273_2:372 ; 52 gi|3122102|sp|O07325|FTSA_STAAU_3:400 ; 53 gi|3122104|sp|O07827|FTSA_PORGI_5:346 ; 54 gi|5805059|emb|CAB53636.1|_3:339 ; 55 gi|7465360|pir||C71873_2:418 ; 56 gi|3122110|sp|O25629|FTSA_HELPY_2:418 ; 57 gi|6968152|emb|CAB72969.1|_5:390 ; 58 gi|7471223|pir||D75494_1:378 ; 59 gi|4138103|emb|CAA75615.1|_2:368 ; 60 gi|3122101|sp|O07111|FTSA_ENTFA_2:344 ; 61 gi|3122103|sp|O07672|FTSA_ENTHR_2:370 ; 62 gi|4009469|gb|AAC95439.1|_2:365 ; 63 gi|120567|sp|P28264|FTSA_BACSU_2:373 ; 64 gi|7443772|pir||G71331_3:385 ; 65 gi|3023796|sp|Q44774|FTSA_BORBU_3:382 ; 66 gi|1196309|gb|AAB51401.1|_3:101 ; 67 gi|1200208|emb|CAA78155.1|_3:382 ; 68 gi|7380686|emb|CAB85276.1|_4:411 ; 69 gi|7225649|gb|AAF40864.1|_4:411 ; 70 gi|1346046|sp|P47203|FTSA_PSEAE_7:230 ; 71 gi|6715614|gb|AAA95992.2|_1:413 ; 72 gi|2707899|gb|AAB92376.1|_1:388 ; 73 gi|4033383|sp|O51928|FTSA_BUCAP_1:414 ; 74 gi|120568|sp|P06137|FTSA_ECOLI_1:412 ; 75 gi|146025|gb|AAA23811.1|_1:412 ; 76 gi|1169751|sp|P45068|FTSA_HAEIN_1:409 ; 77 gi|4433657|gb|AAD20834.1|_9:404 ; 78 gi|3122114|sp|O30994|FTSA_RHIME_17:416 ; 79 gi|3122097|sp|O30991|FTSA_AGRTU_17:416 ; 80 gi|5834365|gb|AAD53931.1|AF179611_15_1:407 ; 81 gi|7443771|pir||D70347_5:413 ; 82 gi|7467594|pir||G71679_6:409 ; 83 gi|7462793|pir||G72328_1:419 ; 84 T0089 ; 85 gi|730060|sp|P39763|MREH_BACSU_6:319 ; 86 gi|2920363|gb|AAC04558.1|_13:329 ; 87 gi|7444221|pir||E71826_13:329 ; 88 gi|7444224|pir||E64691_13:329 ; 89 gi|6967753|emb|CAB72744.1|_14:328 ; 90 gi|7444225|pir||B70189_16:339 ; 91 gi|7444223|pir||E71316_1:321 ; 92 gi|266568|sp|Q01465|MREB_BACSU_9:321 ; 93 gi|7444226|pir||D69660_9:321 ; 94 gi|6983753|emb|CAB75392.1|_11:322 ; 95 gi|2253079|emb|CAA74597.1|_11:321 ; 96 gi|417314|sp|P32444|MBL_BACCE_6:316 ; 97 gi|729993|sp|P39751|MBL_BACSU_6:316 ; 98 gi|2636166|emb|CAB15658.1|_6:302 ; 99 gi|1684654|emb|CAB05381.1|_6:298 10 20 30 40 | | | | 1 ---------AVGIDLGTTYSCVGVWK-........-..NDAVEIIAN.DQgnr20vgdAAKNQVA 2 ---------AVGIDLGTTYSCVGVWK-........-..NDAVEIIAN.DQgnr20vgdAAKNQVA 3 ---------------------------........-..---------.--........------- 4 ---------AVGIDLGTTYSCVGVWK-........-..NDAVEIIAN.DQgnr20vgdAAKNQVA 5 ---------------------------........-..---------.--........------- 6 ---------------------------........-..---------.--........------- 7 ---------------------------........-..---------.--........------- 8 ---------------------------........-..---------.--........------- 9 ---------------------------........-..---------.--........------- 10 -------APAIGIDLGTTYSCVGVFQ-........-..HGKVEIIAN.DQgnr28aamNPSNTVY 11 -------APAIGIDLGTTYSCVGVFQ-........-..HGKVEIIAN.DQgnr28aamNPSNTVY 12 ---------------------------........-..---------.--........------- 13 ---------------------------........-..---------.--........------- 14 -------GVAIGIDLGTTYSCVGVFQ-........-..HGKVEIIAN.DQgnr28valNPSNTVF 15 ----------IGIDLGTTYSC--VGHF........S..NNRVEIIAN.DQgnr28vam------- 16 ----------IGIDLGTTYSCVAVWQ-........-..QDRVEIIAN.DQgnr25knq-----VA 17 ----------VGIDLGTTYSCVGIFR-........-..DDRIEIIAN.DQgnr20igdAAKNQVA 18 ---------------------------........-..---------.--........------- 19 ---------------------------........-..---------.--........------- 20 ----------IGIDLGTTYSCVGIFR-........-..DDRIEIIAN.EQgnr32pqt------- 21 ----------IGIDLGTTYSCVGIYQ-........-..NGKVEILAN.SEgnk28aar------- 22 ---------AIGIDLGTTYSCVGIYQ-........-..NGKVEILAN.SEgnk28aar------- 23 --KEESYGTVIGIDLGTTYSCVGVMQ-........-..SGRVEILAN.DQgnr20vgdAAKNQAP 24 ---EESYGAVIGIDLGTTYSCVGVMQ-........-..SGRVEILPN.DQgnr20vgdAAKNQAP 25 ---------------------------........-..---------.--........------- 26 ---VENYGTVIGIDLGTTYSCVAVMK-........-..NGKTEILAN.EQgnr20igdAAKNQVA 27 ---EEKMGTIIGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr30lti------- 28 -----DIGTVIGIDLGTTYSCVGVYK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 29 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 30 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 31 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 32 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 33 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 34 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 35 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 36 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 37 ----EDVGTVVGIDLGTTYSCVGVFK-........-..NGRVEIIAN.DQgnr21igdAAKNQLT 38 -------GPVIGIDLGTTYSCVGVFK-........-..NGRVEILNN.ELgnr28atlHPTQTVF 39 ---------------------------........-..---------.--........------- 40 ---------------------------........-..NGKVDIIAN.EAgsr20vgeAAKHQMA 41 ---------------------------........-..---------.--........------- 42 ---------------------------........-..---------.--........------- 43 ---------------------------........-..---------.--........------- 44 ---------------------------........-..---------.--........------- 45 ---------------------------........-..---------.--........------- 46 ---------------------------........-..---------.--........------- 47 ---------VIGIDLGTTNSCVAVMDGkna11segM..RTTPSIVAV.TDdge16avt------- 48 ---------------------------........-..---------.--........------- 49 ------GNEIIGIDLGTTNSCVAVMEGknp11seg-a.RTTPSVVAF.NQkgellvgtPAKRQAV 50 -----QGAAVMSVDLGSEWMKVGVVSP........G..VPME--IAL.NResk35say------- 51 ---------IFALDVGTRKIAGLIAVE........E..KGTIRIVDS.ELie......HKTRTMF 52 ------EHYYVSIDIGSSSVKTIVGEK........F..HNGINVIGT.GQ........TYTSGIK 53 ------NTIYAVIDLGSWYIRGMVARK........Me.DGRVSPISF.YEe.......PANNCIR 54 ------KEFIVAIELGSSKMTGIAGQK........Nl.DGSISVLSIvEE........DSTSCIR 55 ----EHKEIVIGVDIGSRKICAIVAEF........K..DGILRIIGT.AHqdske...INSKAIK 56 ----EHKEIVIGVDLGSRKICAIVAEF........K..EGILRIIGT.AHqdske...INSKAIK 57 ---------ILGIDLGSTQTCAIIAQK........D..EDGLKIIGF.SK........SKTNGVK 58 ---MRENSIIVGLDIGTTKITTVIGEV........Ap.DGTIDIIGE.GS........VPSEGMK 59 ----AKSGLYTGVDIGTNTIKVLVAEY........V..SGEMNIIGV.GN........AKSDGLK 60 ---------------------------........-..----NIIGV.GN........AKSDGLN 61 ----AKTGMYVGLDIGTTSVKVVVAEY........I..DSQMNIIGV.GN........AKSEGIN 62 ----AREGFFTGLDIGTSSVKVLVAEQ........R..NGELNVIGV.SN........AKSKGVK 63 ----NNNELYVSLDLGTSNTKVIVGEM........T..GDSLNIIGV.GN........VPSEGLK 64 -------EVIVGLDIGTESIRAVVAER........Le.GGALQVVGV.GV........GHSKGLR 65 ------RNLIVGLDVGTSKICTVVAEV........Nl.NDQLEIVGI.GT........SISRGVR 66 ---------------------------........-..---------.--........------- 67 ------RNLIVGLDVGTSKICTVVAEV........Nl.NDQLEIVGI.GT........SISRGVR 68 -----QQRYISVLDIGTSKVLALIGEV........Qd.DDKINIVGL.GQ........APSRGLR 69 -----QQRYISVLDIGTSKVLALIGEV........Qd.DDKINIVGL.GQ........APSRGLR 70 ---------------------------........-..---------.--........------- 71 MASVQSGKMIVGLDIGTSKVVALVGEV........Ta.DGQLEVVGI.GT........HPSRGLK 72 MANAHSGKMIVGLDIGTSKVVALVGEV........Ge.DGTLEIVGI.GT........HPSRGLK 73 MIISKNRKLVVGLEIGTTKVVTLVGEV........Lt.NGKIKIIGI.GI........CQSNGID 74 MIKATDRKLVVGLEIGTAKVAALVGEV........Lp.DGMVNIIGV.GS........CPSRGMD 75 MIKATDRKLVVGLEIGTAKVAALVGEV........Lp.DGMVNIIGV.GS........CPSRGMD 76 MVKGVETKTIVGLEVGTSKVVVVVGEV........Fp.DGVVNVLGV.GS........CPSKGID 77 --GWRKTRFLTVLDVGSSKIVCLIACLhpl11lygR..THSIEILGF.GM........QRSCGIK 78 -LPSKRSHVVSVLDIGSTKVVCMIGRLtpr11lpgR..THSIEVIGI.GH........QKSRGVK 79 -LSSKRSHIVSVLDIGSTKVVCMIGRLtpr11lpgR..THKVEIIGI.GH........QRSRGVK 80 MTPVKEGNLITALDIGSSKISALIVEK........Ra.DNVLQVLGS.GQ........RESLGVR 81 ----------AALDIGSQKTVFVIGER........Ds.YGDIHIIGF.GE........VPSRGIV 82 -------SNFVTFDFGSSKIAVIAAYI........Sk.KGEIKVASQ.NL........HHSKGIK 83 MIDLSKTVFYTSIDIGSRYIKGLVLGK........R..DQEWEALAF.SS........VKSRGLD 84 MIDLSKTVFYTSIDIGSRYIKGLVLGK........R..DQEWEALAF.SS........VKSRGLD 85 ---------EIGIDLGTANILVYSKNK........GiiLNEPSVVAV.DTttk23gkiVAVRPMK 86 ---------DIAIDLGTANTIVLVKGQ........GiiINEPSIVAV.RMglf28nsiRAIRPMK 87 ---------DIAIDLGTANTIVLVKGQ........GiiINEPSIVAV.RMglf28nsiRAIRPMK 88 ---------DIAIDLGTANTIVLVKGQ........GiiINEPSIVAV.RMglf28nsiRAIRPMK 89 ----------MGIDLGTANTLVLVKDK........GivINEPSVVAV.ERery27gniEAIRPMK 90 ---FKSFLIDIGIDLGTCNTLVYIKDY........GvvMSEPSVVAI.DItkg24eniKAVRPLR 91 MFFLRRFSADVGIDLGTCNTIIYVEGR........GivVNEPSVVAV.ERgtk23gniVAIRPLK 92 ----------LGIDLGTANTLVFVKGK........GivVREPSVVAL.QTdtk23gnvVALRPMK 93 ----------LGIDLGTANTLVFVKGK........GivVREPSVVAL.QTdtk23gnvVALRPMK 94 ---------DMAVDLGTANTLVYVRGR........GivLNEPSVVAI.NTntg23gniVAVRPLK 95 ---------DMAVDLGTANTLVYVRGR........GivLNEPSVVAI.NTntg22rniVAVRPLK 96 ----------IGIDLGTANVLIHVKGK........GivLNEPSVVAI.DRntg23gniVAIRPLK 97 ----------IGIDLGTANVLIHVKGK........GivLNEPSVVAL.DKnsg23gniVAIRPLK 98 ----------IGIDLGTANVLIHVKGK........GivLNEPSVVAL.DKnsg23gniVAIRPLK 99 ----------IGIDLGTANVLIHVKGK........GivLNEPSVVAL.DKnsg23gniVAIRPLK 50 60 70 80 90 | | | | | 1 RNPENTIFDAKRLIGRKFDDPSVQS..DMKHWPF........KVIAGPGD---.....--KPLI. 2 RNPENTIFDAKRLIGRKFDDPSVQS..DMKHWPF........KVIAGPGD---.....--KPLI. 3 -------FDAKRLIGRKFDDPSVQS..DMKHWPF........KVIAGPGD---.....--KPLI. 4 RNPENTIFDAKRLIGRKFDDPSVQS..DMKHWPF........KVIAGPGD---.....--KPLI. 5 -------------------------..-------........-----------.....---PNI. 6 -------------------------..-------........-----------.....------. 7 -------------------------..-------........-----------.....------. 8 -------------------------..-------........-----------.....------. 9 -------------------------..-------........-----------.....------. 10 --------DAKRLIGRKFDDKTVQN..DMKHWPF........KVVEVDGRPK-.....-----I. 11 --------DAKRLIGRKFDDKTVQN..DMKHWPF........KVVEVDGRPK-.....-----I. 12 -------------------------..-------........-----------.....------. 13 -------------------------..-------........-----------.....------. 14 --------DAKRLIGRKFDEPVVQA..DMKHWPF........KVISDGGK---.....---PKI. 15 -NPHNTIFDAKRLIGRRFNDPEVQS..DMKHWPF........KVIEKDGKP--.....----LI. 16 MNPYNTVFDAKRLIGRKFEDAEVQS..DMKHWPF........KVISRLASLHQ.....VEYARG. 17 MNPANTVFDAKRLIGRKFADPEVQA..DMKHFPF........KIT------DK.....GGKPVI. 18 -------------------------..-------........-----------.....------. 19 -------------------------..-------........-----------.....------. 20 ------VFEAKRLIGRKFADPEVQA..DMKHFPF........------KITDK.....GGNPKI. 21 -NPENTVFDAKRLIGRRFDESTVQS..DCKHWP-........-----FGVKGK.....QGKPVI. 22 -NPENTVFDAKRLIGRRFDEETVQS..DIKHWP-........-----FTVKGK.....QGKPVV. 23 ANPLNTIFDVKRLIGRRFDDVDVQA..DMKHWP-........-----FKVHHQ.....DGKPHV. 24 ANPLNTIFDVKRLIGRRFDEADVQS..DIKNFP-........FKVNHHE----.....-GKPHV. 25 -------------------------..-------........-----------.....------. 26 ANPQNTIFDIKRLIGLKYNDRSVQK..DIKHLPF........NVVNKDGK---.....---PAV. 27 -NPENTIFDAKRLIGRFYNEKTVQQ..DIKHWPF........KIVD------K.....SNKPNV. 28 TNPENTVFDAKRLIGREWSDQTVQH..DVKFFPF........KV------VEK.....NSKPHV. 29 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 30 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKYLPF........KV------VEK.....KAKPHI. 31 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 32 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 33 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 34 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 35 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 36 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 37 SNPENTVFDAKRLIGRTWNDPSVQQ..DIKFLP-........-----FKVVEK.....KTKPYI. 38 D--------VKRLIGRKFDDQEVVK..DRSLLPY........EIVNNQGK---.....---PNI. 39 -------------------------..-------........-----------.....------. 40 NNPHNTIFAIKRLMGLRYSDKEVQN..ELKRLPY........KVIDQDNR---.....---PFV. 41 -------FDAKRLIGRKFTDSIVQS..DMKLWPF........DVVDESGR---.....---PKI. 42 -------------------------..-------........-----------.....------. 43 -------------------------..-------........-----------.....------. 44 -------------------------..-------........-----------.....------. 45 -------------------------..-------........-----------.....------. 46 -------------------------..-------........-----------.....------. 47 -NPERTFFAVKRLIGRRYDDPMVEK..DKKLVPY........KIVKASNGD-A.....WVEADG. 48 ------LSGTKRLIGRRFDDPQTQK..EMKMVP-........YKIVKGSNGDA.....WVEANG. 49 TNPTNTLSGTKRLIGRRFDDPQTQK..EMKMVP-........YKIVRGSNGDA.....WVEANG. 50 -GYLLD-----------------LL..GKTIDN-........PIVDLYRKRFP.....YYNIVGd 51 DGQVHDVLGVAETVKEVKERLESRN..EIELKE-........VAVALAGRFLK.....TQVGEA. 52 NGLIDDFDIARQAIKDTIKKASIAS..GVDIKE-........VFLKLPIIGTE.....VYDESN. 53 HGCVHNIDEAAAIIRRIVNQLNENLedNTHITS-........LYVGVGGQSIA.....SQEFIV. 54 KGVVYNIEKTGQCLTSIMQKLKNNL..KQDITH-........VYVGVGGQSIR.....SVKNVI. 55 RGRINSLAHASNAIKEVINSAKKMA..GLNADEDrnn17ktkAIVSFSGAYTE.....SIRDVT. 56 RGRINSLAHASNAIKEVINSAKKMA..GLNADEDrnn16ktkAIVSFSGAYTE.....SIRDVT. 57 KGAITNIELASKSIEEAVRSAEMMS..GVHYDR-........VVVSISGAYTK.....SVDSIG. 58 RGSVINLERATQAIKQSLHAAERVS..GVRAWN-........VFVSVGGNHTK.....AMTSHG. 59 NGIIVDIEKVAQALRKAVNAAEERA..GITIDR-........INVSIPANSLE.....MEPCQG. 60 RGIVVDIDQTVQAIQRAVRQAEEKA..GIQIKS-........VNVGLPANLLE.....VESCQG. 61 RGIIVDIDKTVQAIQRAVRQAEEKA..GIQIKG-........VSVGLPANLLE.....VENCQG. 62 DGIIVDIDAAATAIKSAISQAEEKA..GISIKS-........VNVGLPGNLLQ.....VEPTQG. 63 KGSIVDIDETVHSIRKAFDQAERMV..GFPLRK-........AIVGVNGNYIN.....IQDTNG. 64 RGVVVNIENTVVGIHHAVEAAEMMS..GIEVAH-........CVVGLGGTHIE.....GRNLKG. 65 KGVLINIEAALDSISNSIEAAELIS..GCDITS-........LSVSMSGSSVE.....GTNSRG. 66 -------------------------..-------........-----------.....------. 67 KGVLINIEAALDSISNSIEAAELIS..GCDITS-........LSVSMSGSSVE.....GTNSRG. 68 AGMVTNIDATVQAIRQAVNDAELMA..DTKITH-........VTTGIAGNHIR.....SLNSQG. 69 AGMVTNIDATVQAIRQAVNDAELMA..DTKITH-........VTTGIAGNHIR.....SLNSQG. 70 -------------------------..-------........-----------.....------. 71 KGVVVNIESTVQSIQRAIDEAQQMA..GCRIHS-........AFVGIAGNHIR.....SLNSHG. 72 KGVVVNIESTVQSIQRAVEEAQLMA..GCRIHS-........AFVGVAGNHIR.....SLNSHG. 73 KGRINDLDAVISCIRESIHQAEIMA..NCQITS-........VYLSLSSKYIN.....CPNEIG. 74 KGGVNDLESVVKCVQRAIDQAELMA..DCQISS-........VYLALSGKHIS.....CQNEIG. 75 KGGVNDLESVVKCVQRAIDQAELMA..DCQISS-........VYLALSGKHIS.....CQNEIG. 76 RGSITDLDAVVGSIQRAIEAAESMA..DCQIMS-........VTLAITGEHIQ.....SLNESG. 77 SGVIMDMVAAERSIRLAVDAAEKMA..GLVVDS-........VIVNFSSSCLK.....SSFING. 78 NGVIADLDAVESVVRLAVDAAERMA..GLTIDS-........LIVNVSAGRLQ.....SDVYTA. 79 SGVIADLDALEGVIRLSVDAAERMA..GLTVDS-........LIVNVSAGRLA.....SDIYTA. 80 RGYLFDMESTEKAVREAVEQAERIA..GTNIES-........VWVSFSAGGLI.....SDLSST. 81 KGVINDLSEAKGSILRAMKEAEAMA..GLKVRE-........VVYNVSGGTTKngtvkSQNVKD. 82 SGVILDLKNAETSILTAIYALEKDC..GKNINK-........IILSLSGAETK.....SYYINY. 83 EGEIKDAIAFKESVNTLLKELEEQL..QKSLRSD........FVISFSSVSFE.....REDTVI. 84 EGEIKDAIAFKESVNTLLKELEEQL..QKSLRSD........FVISFSSVSFE.....REDTVI. 85 DGVIADYDMTTDLLKHIMKKAAKSI..GMSFRK-........-----------.....---PNV. 86 DGVIADYDITAKMIRYFIEKAHKRK..TWIRPR-........-----------.....-----I. 87 DGVIADYDITAKMIRYFIEKAHKRK..TWIRPR-........-----------.....-----I. 88 DGVIADYDITAKMIRYFIEKVHKRK..TWIRPR-........-----------.....-----I. 89 DGVIADFDMTEKMIRYFIEKTHRRK..SFLRPR-........-----------.....-----I. 90 DGVIADIENTEKMIKYFINQIFSRK..KLFFKP-........-----------.....----RM. 91 DGVIADMDTTEKMIRYFISKILPRH..RLIKPR-........-----------.....-----M. 92 DGVIADYETTATMMKYYINQAIKNK..GMFARK-........-----------.....---PYV. 93 DGVIADYETTATMMKYYINQAIKNK..GMFTRK-........-----------.....---PYV. 94 DGVIADFEITERMLRYFILKIHKRR..YLARPR-........-----------.....-----V. 95 DGVIADFEITERMLRYFILKIHKRR..YLARPR-........-----------.....-----V. 96 DGVIADFEITEAMLKYFINKLDVKS..FFSKPR-........-----------.....-----I. 97 DGVIADFEVTEAMLKHFINKLNVKG..LFSKPR-........-----------.....-----M. 98 DGVIADFEVTEAMLKHFINKLNVKG..LFSKPR-........-----------.....-----M. 99 DGVIADFEVTEAMLKHFINKLNVKG..LFSKPR-........-----------.....-----M. 100 110 120 130 140 | | | | | 1 .....EVTY...QGE.KKTFHPEEVSAMVLGKMKEiaeaYLGKEVKEAVITVPAYFNDSQRQATK 2 .....EVTY...QGE.KKTFHPEEVSAMVLGKMKEiaeaYLGKEVKEAVITVPAYFNDSQRQATK 3 .....EVTY...QGE.KKTFHPEEVSAMVLGKMKEiaeaYLGKEVKEAVITVPAYFNDSQRQATK 4 .....EVTY...QGE.KKTFHPEEVSAMVLGKMKEiaeaYLGKEVKEAVITVPAYFNDSQRQATK 5 .....EVTF...QGE.RKTFHAEEISSMVLTKMKEiaeaFIGKTVKDVVITVPAYFNDSQRQATK 6 .....----...---.-------------------....-------------------------- 7 .....----...---.-------------------....-------------------------- 8 .....----...---.-------------------....-------------------------- 9 .....----...---.-------------------....-------------------------- 10 .....QAEY...RGE.NKLFAPEEISSMVLTKMKEtaeaYLGQKITDSVITVPAYFNDSQRQATK 11 .....QAEY...RGE.NKLFAPEEISSMVLTKMKEtaeaYLGQKITDSVITVPAYFNDSQRQATK 12 .....----...---.-------------------....---------------YFNDAQRQATK 13 .....----...---.-------------------....-------------------------- 14 .....RVEY...KGE.DKAFYPEEISSMVLVKMKEiaeaYLGQKVSNAVITVPAYFNDSQRQATK 15 .....QVEF...KGE.TKTFTPEEISSMVLLKMREsaeaFLGGKVTDAVVTVPAYFNDSQRQATK 16 .....----...---.-EEFSPEEISSMVLIKMKEtaeaYLGGTVSKAVVTVPAYFNDSQRQATK 17 .....QVEF...KGE.TKEFTPEEISSMVLTKMREtaeaYLGGTVNNAVVTVPAYFNDSQRQATK 18 .....----...---.--------------ETAES....YLGGTVNNAVVTVPAYFNGSQRQATK 19 .....----...---.-------------------....-------------------------- 20 .....QVEF...RGE.GKHFTPEGISSMFRRKKREiaesYLGGTVNNAVVTVPAYFNDSQRQVTK 21 .....EVEV...KGE.KRQFNPEEISAMVLQKMKEtaetYLGHTVKDAVITVPAYFNDSQRQATK 22 .....EVEV...KGE.KREFNAEEISAMVLQKMKEtaeaVLGHSVRDAVITVPAYFNDSQRQATK 23 .....IVNI...AGE.KKTFTPEEISAMVLRKMKEiaesYLGRTVTHAVVAVPAYFNDAQRQATK 24 .....EVNI...AGE.KKTFTPEEISAMVLRKMKEiaesYLGRTVTHAVVTVPAYFNDAQRQATK 25 .....----...---.-------------------....-------------PAYFNDAQRQATK 26 .....EVSV...KGE.KKVFTPEEISGMILGKMKQiaedYLGTKVTHAVVTVPAYFNDAQRQATK 27 .....EVKV...GSE.TKQFTPEEVSAMVLTKMKQiaesYLGHEVKNAVVTVPAYFNDAQKQATK 28 .....QVQT...SQG.DKVFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 29 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 30 .....QVDV...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 31 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 32 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 33 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 34 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 35 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 36 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 37 .....QVDI...GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATK 38 .....KVQI...KDK.DTTFAPEQISAMVLEKMKEiaqsFLGKPVKNAVVTVPAYFNDAQRQATK 39 .....----...---.---FAPEQISAMVLEKMKEiaqsFLGKPVKNAVVTVPAYFNDAQRQATK 40 .....EVQY...KGK.TEHYSPEEISAMILSKMKTiaeeYLGRPVKNAVVTCPAYFNDAQRKATA 41 .....KVTH...QCK.DKTFFAEEISSMVLGKMKEtaeaYLGKTVNDAVITVPAYFNDSQRQATK 42 .....----...---.-------------------....-------------------------- 43 .....----...---.-------------------....-------------------------- 44 .....----...---.-------------------....-------------------------- 45 .....----...---.-------------------....-------------------------- 46 .....----...---.-----------------ES....YLGSKVKNVVITVPAYFNDSQRQATK 47 .....----...---.-QTYSPSQVSAFILQKMKEtaeaHLGQKVDQAVITVPAYFNDAQRQATK 48 .....QQYS...PSQ.IGAFILTKMKETAEAYLGK....----SINKAVITVPAYFNDAQRQATK 49 .....QQYS...PTQ.IGAFILTKMKETAEAYLGK....----SINKAVITVPAYFNDAQRQAIK 50 perntVVFR...KSD.TDEFSVEELVAQLLVKAKQfaqeSVQQPITECVLTVPGYF--------- 51 .....ELDF...SK-.VGHITREDVMKLEIEAVTKaqe.SVEEDFFCVGYSVVEYRLDGMW-MKK 52 .....EIDF...YED.-TEINGSHIEKVLEGIREK....NDVQETEVINVFPIRFIVDKENEVSD 53 .....RKAM...VPE.GEVIRTEHIESLWAEMRGA....SFP-DKEVLDVTDPLFYVDGKQ-EIQ 54 .....VKDL...PSA.-TQVTQEMVNELMDANRNM....SYP-DLEILDAATQEYKLDNQF-QLD 55 .....GVAS...TKD.-NVVTIDEINRAINNACAKa...GLDNDKHILHALPYRFTLDKQE-VND 56 .....GVAS...TKD.-NVVTIDEINRAINSACAKa...GLDNDKHILHALPYRFTLDKQE-VND 57 .....VVNI...PN-.-HEIGIKEIHRAVSTAKHTa...NLPSGYEIIHVLPYNFKVNDLEHVDD 58 .....LAAI...RRQ.-QEISPPDVERAIENARAV....PLDPSLEILHTIPQEYVVDGQEGIKN 59 .....MVPI...VSD.TKEITDNDVIQVVQNALMR....GIVPEREIIAVETKEFTVDGFTGISD 60 .....MIAV...SSE.SKEITDEDVCNVASAALVR....STPPERQIVAILPQDFTVDGFEGIKD 61 .....MIAV...NGD.SKEITDEDVRNVASAALVR....SIPPERQIVSILPQDFTVDGFEGIKD 62 .....MIPV...TSD.TKEITDQDVENVVKSALTK....SMTPDREVITFIPEEFIVDGFQGIRD 63 .....VVAV...SSE.NKEIQVEDVRRVMAAAQVV....SVPHEQLIVDVIPKQFIVDGRDEITD 64 .....VVAVadkGKG.HREVDQSDIDRVLEVACAV....SLPPDRKILHVIPKVYSVDDQHGITD 65 .....VVAI...NSK.TREINEEDVERVIEAAKAI....VIPMDREILHVIPQEFIVDGIPHIKN 66 .....----...---.-------------------....-------------------------- 67 .....VVAI...NSK.TREINEEDVERVIEAAKAI....VIPMDREILHVIPQEFIVDGIPHIKN 68 .....VVKI...KD-.-GEVTQADIDRAIETAKAI....NIPPDQKILDAVVQDYIIDTQLGVRE 69 .....VVKI...KD-.-GEVTQADIDRAIETAKAI....NIPPDQKILDAVVQDYIIDTQLGVRE 70 .....----...---.-------------------....-------------------------- 71 .....IVAI...RD-.-REVNPADIERVLDAAQAV....AIPADQRVLHTLAQDYVIDNQEGVRE 72 .....IVAI...RD-.-REVSLADLERVLDAAQAV....AIPADQRVLHTLPQDYVIDNQEGVRE 73 .....IVPI...SE-.-DEVTKEDIENVIHTAKSV....KILNEHHILHVIPQEYSIDQQSGIKN 74 .....MVPI...SE-.-EEVTQEDVENVVHTAKSV....RVRDEHRVLHVIPQEYAIDYQEGIKN 75 .....MVPI...SE-.-EEVTQEDVENVVHTAKSV....RVRDEHRVLHVIPQEYAIDYQEGIKN 76 .....FVPI...AE-.-SEVTQEEIDSALHTASSI....KLPEGLSLLHVIPQEYAVDRQMNIKN 77 .....TVCL...DG-.-HEVTPYDVRMALADVSRK....AFDAEHHIVHTVPAFYALDGNKGIVD 78 .....TIDL...GG-.-QEVEANDLKKVLAAAGHQ....SLRTDRAILHSLPTGFSLDGERGIRD 79 .....SIDL...GG-.-QEVEASDLRKVLVAASQQ....SMRQDRAILHSLPTGYSLDGERGIRD 80 .....EVAL...NG-.-QRIEEIHMETLLATGRDA....IDPDGHMVLHAQPALYTLDGLKGVKS 81 .....TISI...STK.SSEIEESHIQRLHERCLMK....AKEEGYEIVYTAPRKYILDDHTEVKN 82 .....TIKI...NG-.-QTVTQQDIKKLLQKALVE....FKFKNQEIIHYFPLEFTLDNNS-VEN 83 .....ERDF...GEE.KRSITLDILSEMQSEALEK....LKENGKTPLHIFSKRYLLDDERIVFN 84 .....ERDF...GEE.KRSITLDILSEMQSEALEK....LKENGKTPLHIFSKRYLLDDERIVFN 85 .....VVCT...PSG.STAVERRAISDAVKN----....-------------------------- 86 .....MVCV...PYG.LTSVERNAVKESALS----....-------------------------- 87 .....MVCV...PYG.LTSVERNAVKESALS----....-------------------------- 88 .....MVCV...PYG.LTSVERNAVKESTLS----....-------------------------- 89 .....IISV...PYG.LTQVERKAVRESALS----....-------------------------- 90 .....VIGV...PTC.ITEVERRAVKESAMN----....-------------------------- 91 .....VIGI...PSC.ITDVECRAVHESASK----....-------------------------- 92 .....MVCV...PSG.ITAVEERAVIDATRQ----....-------------------------- 93 .....MVCV...PSG.ITAVEERAVIDATRQ----....-------------------------- 94 .....VVCV...PSG.ITGVERRAVIEASSQ----....-------------------------- 95 .....VVCV...PSG.ITGVERRAVIEASSQ----....-------------------------- 96 .....LICC...PTN.ITSVEQKAIREAAER----....-------------------------- 97 .....LICC...PTN.ITSVEQKAIKEAAEK----....-------------------------- 98 .....LICC...PTN.ITSVEQKAIKEAAEK----....-------------------------- 99 .....LICC...PTN.ITSVEQKAIKEAAEK----....-------------------------- 150 160 170 180 190 200 | | | | | | 1 DAGTI---.-----------------------.-AGLSVLRIINEPTAAAIAYGLDKkg...CGE 2 DAGTI---.-----------------------.-AGLSVLRIINEPTAAAIAYGLDKkg...CGE 3 DAGTI---.-----------------------.-AGLSVLRIINEPTAAAIAYGLDKkg...CGE 4 DAGTI---.-----------------------.-AGLSVLRIINEPTAAAIAYGLDKkg...CGE 5 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKks...GGE 6 --------.-----------------------.----------------AIAYGLDKkg...KGE 7 --------.-----------------------.------------------------.....--- 8 --------.-----------------------.-AGLEVLRIVNEPTAAAIAYGRDRsse..GAM 9 --------.-----------------------.------------------------.....--- 10 DAGAI---.-----------------------.-AGLNVLRIINEPTAAALAYGLDKgh...KGE 11 DAGAI---.-----------------------.-AGLNVLRIINEPTAAALAYGLDKgh...KGE 12 DAGAI---.-----------------------.-AGLNVLRIINEPTAAALAYGLDKgq...KGE 13 ---AI---.-----------------------.-AGLNVLRIINEPTAAALAYGLDKgq...KGE 14 DAGVI---.-----------------------.-AGLNVLRIINEPTAAAIAYGLDKgk...SGE 15 DAGLI---.-----------------------.-AGLNVLRIINEPTAAAIAYGLDRsn...QHE 16 DAGTI---.-----------------------.-AGLEVLRIINEPTAAAIAYGLDKks...EGE 17 DAGLI---.-----------------------.-AGLNVLRIINEPTAAAIAYGLDKka...DGE 18 DAGLI---.-----------------------.-AGLNVLRIINEPTAAAIAYGLDKka...EGE 19 --------.-----------------------.---------------AAIAYGLDKka...EGE 20 DAGLI---.-----------------------.-AGLNVLRIINEPTAAAIAYGLDKka...EGE 21 DAATI---.-----------------------.-AGLNAIRIINEPTAAALAYGLDKgi...QDE 22 DAATI---.-----------------------.-AGLNAIRIINEPTAAALAYGLDKgi...TDE 23 DAGTI---.-----------------------.-AGLNVLRIVNEPTAAAIAYGLDKk....EGE 24 DAGTI---.-----------------------.-AGLNVLRIVNEPTAAAIAYGLDKk....EGE 25 DAGKI---.-----------------------.-AGLNVLRILNEPTAAAMAYGLNKv....TGE 26 DAGTI---.-----------------------.-AGLNVLRIVNEPTAAAIAYGLDKs....DKE 27 DAGSI---.-----------------------.-AGLNVVRIINEPTAAAIAYGLDKk....DGE 28 DAGTI---.-----------------------.-SGLNVMRIINEPTAAAIAYGLDKk....EGE 29 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 30 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 31 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 32 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 33 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 34 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 35 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 36 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 37 DAGTI---.-----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGE 38 DAGTI---.-----------------------.-AGLNIVRIINEPTAAALAYGLDK.....KEE 39 DAGTI---.-----------------------.-AGLNIVRIINEPTAAALAYGLDK.....KEE 40 DAGTI---.-----------------------.-AGLNVVRILNEPTAASLAYGLNK.....KGS 41 DAGVI---.-----------------------.-ARINVLRIINEPIAAAIAYGLDKkgnt.QGE 42 --------.-----------------------.IAGLEVERIINEPTAAALAYGLEK.....KKN 43 --------.-----------------------.IAGLEVLRIVNEPTAAALAYGLDK.....KKD 44 --------.-----------------------.IAGLEVLRIVNEPTAAALAYGSDK.....KKD 45 --------.-----------------------.-AGLEVERIINEPTAAALAYGFDKk....NVN 46 DAGKI---.-----------------------.-AGMEVLRVINEPTAAALAYGLDR.....TDD 47 DAGKI---.-----------------------.-AGLEVLRIINEPTAAALAYGLDK.....TKT 48 DAGRI---.-----------------------.-AGLDVQRIINEPTAAALSYGMNS.....KEG 49 DAGAI---.-----------------------.-AGLDVQRIINEPTAAALSYGMNS.....KEG 50 --------.----------GQAEREALLSAAQ.LANLKVLQLINDYAAVALNYGVFHrgeinETA 51 LEGHRGGK.AYVKVVSAFLPVHVVDSLMRVLE.TVGLTPVHVTLEPIAAMDLTVPED.....LRY 52 PKELIARHsLKVEAGVIAIQKSILINMIKCVE.ACGVDVLDVYSDAYNYG-SILTAT.....EKE 53 AKGVFCHE.LEARFQLITARRSVKQNIRIAIEeRLGLRLAGILVTPLCEAQVLLSDD.....ELT 54 PVGIQCTH.LEGNFLNILWRKNFYRNLNTCFD.NAGIAIAEMYLAPLALADSTLTDA.....EKR 55 PLGMSGTR.LEVFIHIVYTEKNNIENLEKIMI.QSGVEIENIVINSYAASIATLSND.....ERE 56 PLGMSGTR.LEVFIHIVYTEKNNIENLEKIMI.QSGVEIENIVINSYAASIATLSND.....ERE 57 PLGMSGNR.LEVSTHIVISQESHIKNLKKAVE.LADLRVDNIVLSGYASAIACLDDS.....EKE 58 PVGMHGVR.LEVDVHIVAGSAGPLLNLRRCVQ.EAGLQIEGFVLHSLASGLATLDHS.....EQN 59 PRGMFGVR.LEIRGVVYTGPKTLVHNVRKVVE.RAGLLVDNIVIAPLAMRQYVLTEG.....ERE 60 PRGMLGVR.MEMFGVVYTGPKTIIHNIRKCVE.KAGLGINELVITPLALTETILTDG.....EKD 61 PRGMIGVR.LEMYGLLFTGPKTIVHNIRKCVE.NAGLVVNELVITPLALTETILSDG.....EKD 62 PRGMMGVR.LEMRGLLYTGPRTILHNLRKTVE.RAGVQVENVIISPLAMVQSVLNEG.....ERE 63 PKKMLGVR.LEVEGTLITGSKTILHNLLRCVE.RAGIEITDICLQPLAAGSAALSKD.....EKN 64 PRNIIGVR.LEGEVHMITGSATCMRSVIDCVK.RANLHIDFLMHNGLAAVRSVLNDD.....ERN 65 PIDMMGIR.LEGEVHIITGSSSSSQNLVRCVN.RAGFAVDEVVLGSLASSYATLSKE.....ERE 66 --------.-----------------------.------------------------.....--- 67 PIDMMGIR.LEGGVHIITGSSSSSQNLVRCVN.RAGFAVDEVVLGSLASSYATLSKE.....ERE 68 PIGMSGVR.LDTRVHIITGASTAVQNVQKCIE.RCGLKSDQIMLQPLASGQAVLTED.....EKD 69 PIGMSGVR.LDTRVHIITGASTAVQNVQKCIE.RCGLKSDQIMLQPLASGQAVLTED.....EKD 70 --------.-----------------------.-------------LASAYSVLTED.....EKE 71 PLGMSGVR.LEAKVHVVTCAVNASQNIEKCVR.RCGLEVDDIILEQLASAYSVLTED.....EKE 72 PLGMSGVR.LEAKVHVVTCAVNAAQNIEKCVR.RCGLEIDDIILEQLASAYSVLTDD.....EKE 73 PIGLSGTR.MQVRVHLITCHQNMAKNIIKAVE.KCDIKVDQVIFSGLASSKAVLTED.....ECK 74 PVGLSGVR.MQAKVHLITCHNDMAKNIVKAVE.RCGLKVDQLIFAGLASSYSVLTED.....ERE 75 PVGLSGVR.MQAKVHLITCHNDMAKNIVKAVE.RCGLKVDQLIFAGLASSYSVLTED.....ERE 76 PLGLQGVR.LKAQVHLIACHQDWQNNLKKAVE.RCGLQVDKVVFSGFAATHSVLTED.....EKD 77 PIGMIGKT.LGVNVHVVTAETAPLRNLETCIN.RAHLSVEAMVATPFASGLSVLIND.....EAR 78 PLAMFGDV.LGVDMHVLTAERPALKNLELCVN.RAHLSVEGMVATPYASGLAALVDD.....EVE 79 PLSMYGDL.LGVDMHVVTVERTALKNLELCVN.RAHLSVEGMVATPYASGLAALVDD.....EVE 80 PIGLYADR.LGVDIHVIAAEPSPVRYLELAVR.SAHLEVQAIVAAPIAAGMSCLFAE.....ERE 81 PLGLVGSK.LSVEMHVVKVSTTILRNLEKAIR.EVGLNPVGRTVNAIASADSVLTHD.....EKE 82 PIGMYGRA.LSCELHIISARSNLLSNIVQCFA.KCHVEVTNITLAIYASAISCLTND.....EKN 83 PLDMKASK.IAIEYTSIVVPLKVYEMFYNFLQ.DTVKSPFQLKSSLVSTAEGVLTTP.....EKD 84 PLDMKASK.IAIEYTSIVVPLKVYEMFYNFLQ.DTVKSPFQLKSSLVSTAEGVLTTP.....EKD 85 --------.-----------------------.-CGAKNVHLIEEPVAAAIGADLPV.....DEP 86 --------.-----------------------.-AGAREVFLIEEPMAAAIGAGLPV.....KEP 87 --------.-----------------------.-AGAREVFLIEEPMAAAIGAGLPV.....KEP 88 --------.-----------------------.-AGAREVFLIEEPMAAAIGAGLPV.....KEP 89 --------.-----------------------.-AGAREVFLIEEPMAAAIGASLPI.....QEP 90 --------.-----------------------.-AGAREVKVIEESLAAAIGSDIPI.....FEP 91 --------.-----------------------.-AGAGEVEVLEESLAAAIGANIPI.....EEP 92 --------.-----------------------.-AGARDAYPIEEPFAAAIGANLPV.....WEP 93 --------.-----------------------.-AGARDAYPIEEPFAAAIGANLPV.....WEP 94 --------.-----------------------.-AGARQVHIIEEPMAAAIGSGLPV.....HEA 95 --------.-----------------------.-AGARQVHIIEEPMAAAIGSGLPV.....HEA 96 --------.-----------------------.-SGGKTVFLEEEPKVAAVGAGMEI.....FQP 97 --------.-----------------------.-SGGKHVYLEEEPKVAAIGAGMEI.....FQP 98 --------.-----------------------.-SGGKHVYLEEEPKVAAIGAGMEI.....FQP 99 --------.-----------------------.-SGGKHVYLEEEPKVAAIGAGMEI.....FQP 210 220 230 240 250 | | | | | 1 MNVLIFDMGGGTFDVSLLTIEDGIFevkat...AGDTHLGGEDFDNRLVdfc20tnsRALRRLRT 2 MNVLIFDMGGGTFDVSLLTIEDGIFevkat...AGDTHLGGEDFDNRLVdfc20tnsRALRRLRT 3 MNVLIFDMGGGTFDVSLLTIEDGIFevkat...AGDTHLGGEDFDNRLVdfc20tnsRALRRLRT 4 MNVLIFDMGGGTFDVSLLTIEDGIFevkat...AGDTHLGGEDFDNRLVdfc20tnsRALRRLRT 5 KNVLIFDLGGGTFDVSILTIEDGIFevkat...AGDTHLGGEDFDNLLVehc20snkRALRRLRT 6 RNILIFDLGGGTFDVSLLTIDDGIFevkat...AGDTHLGGEDFDNRMVnyf19gnpRALRRLRT 7 -------------------------........------GGEDFDNRMVnhf19gnpRALRRLRT 8 KTVLIFDLGGGTFDVTLLNIDGGLFevrat...AGDTHLGGEDFDSRLVdyf19gnaRAMRRLRT 9 -----------------LNINGGVFavkat...AGDTHLGGEDFDNALLehf19ddaRALRRLRS 10 KNVLIFDLGGGTFDVSILTIDEGSMfevkat..AGDTHLGGEDFDNRMVthf19snpRAIRRLQT 11 KNVLIFDLGGGTFDVSILTIDEGSMfevkat..AGDTHLGGEDFDNRMVthf19snpRAIRRLQT 12 KHVLIFDLGGGTFDVSVLAIDEGSIfevkat..AGDTHLGGEDFDNRLVahf19knaRAIRRLRT 13 KHVLIFDLGGGTFDVSVLAIDEGSIfevkat..AGDTHLGGEDFDNRLVahf19knaRAIRRLRT 14 RNVLIFDLGGGTFDVSILTIEDGIFevkst...AGDTHLGGEDFDNRMVnhf19qnkRALRRLRT 15 TNVLIFDLGGGTFDVSLLTIEEGIFevkat...AGDTHLGGEDFDSRLVnhf19gnaRAVRRLRT 16 KNVLIFDLGGGTFDVSLLTIEEGIFevkat...AGDTHLGGEDFDNRLVnhf19snaRALRRLRT 17 RNVLIFDLGGGTFDVSLLTIEEGIFevkst...AGDTHLGGEDFDNRLVnhf20eraRALRRSPT 18 RNVLIFDLGGGTFDVSLLTIEEGIFevkst...AGDTHLGGEDFDNRLVnhf19snaRALRRLRT 19 RNVLIFDLGGGTFDVSLLTIEEAIFevkst...AGDTHLGGEDFDNRLVnhf19fnaRALRRLRT 20 RNVLILDLGGGTFDVSLLTIEEGIFevkst...AGDTHFGGEDFDNRLVnhf19snaRALRRLRT 21 KNVLIFDLGGGTFDVSILSIAEGSIfevkst..AGDTHLGGEDFDQRMLqhf19pnpRAIRRLRT 22 KNILIFDLGGGTFDVSILSIAEGSIfevkst..AGDTHLGGEDFDSRVLqhf19snpRAIRRLRT 23 RLIIVYDLGGGTFDVSLLSIEDGVFeviat...AGDTHLGGEDFDHQVMsyf19ddpKALGKLKR 24 RLIIVYDLGGGTFDVSLLSIEDGVFeviat...AGDTHLGGEDFDHQVMahf19sdpKALGKLKR 25 KNILVFDLGGGTFDVSLLNIEENVFdvvst...SGDTHLGGSDFDQKVTeyl19kdkRAVTRLRR 26 HQIIVYDLGGGTFDVSLLSIENGVFevqat...SGDTHLGGEDFDYKIVrql19dnnKALAKLKR 27 RNILVFDLGGGTFDVSLLTIDSGVFevlat...NGDTHLGGEDFDQRVMeyf19kdnRAVQKLRR 28 KNVLVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 29 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 30 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 31 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 32 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 33 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 34 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 35 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 36 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 37 KNILVFDLGGGTFDVSLLTIDNGVFevvat...NGDTHLGGEDFDQRVMehf19kdnRAVQKLRR 38 TSILVYDLGGGTFDVSILVIDNGVFevyat...AGNTHLGGEDFDQRVMdyf19tdkRAIQKLRK 39 TSILVYDLGGGTFDVSILVIDNGVFevyat...AGNTHLGGEDFDQRVMdyf19tdkRAIQKLRK 40 KKILVFDLGGGTFDVSCLAVDDGLFevlat...GGDTHLGGEDFDDRTIeyl19knaKAMAKLKR 41 RNVLIFDLGGGTFDVSILSIEDGIFevkst...NGDTHLGGEDFDNRMVnhf19nnkRSLRRLRT 42 EKIVVFDLGGGTFDVSVLEVTEELVevlst...NGDTHLGGDDFDEELInfi19kdpMALQRLRE 43 ETIAVFDFGGGTFDISILEVGEGVVevkst...NGDTHLGGDDIDEALVgwi18aqdKMALQRLK 44 ETIAVYDFGGGTFDISILEVGEGVVevkst...NGDTHLGGDNIDQKVMdwi19kdkMALQRLKE 45 SKIAVYDLGGGTFDISILELADGVFevkst...NGDTHLGGDDFDMAIMewm19adkNTVQRLKE 46 KTIAVYDLGGGTFDISVLEIQKGVFevkst...NGDTFLGGEDFDNELLrfl19kdpMALQRVKE 47 GTIAVYDLGGGTFDISILEIGDGVFevkst...NGDTFLGGEDFDMRLVgyl19ndkLALQRLKE 48 L-VAVFDLGGGTFDVSILEISNGVFevkat...NGDTFLGGEDFDNALLefl19kdkLALQRLRE 49 L-VAVFDLGGGTFDVSILEISNGVFevkat...NGDTFLGGEDFDNALLefl19kdkLALQRLRE 50 QYFLFYDMGAYKTSAAVVSYQLVKDkqt15lgvGYDRTLGGLEIQLRLRdyl21tspRALAKLFK 51 LNISLVDVGAGTSDIAISKEGTVVA........YGMIPMAGDEITEAIG........KKFLLDFQ 52 LGACVIDIGEDVTQVAFYERGELVD........ADSIEMAGRDITRRYCtri.....KALLMKL- 53 LGCCYVNIGAGCTSVSIYKNRLLAM........LRVLPMGGYNVTRDL-........TSLRLTEQ 54 SGCVLIDLGADTTTVSVYYKNILRH........LAVIPLGGSNITKDI-........ASLQMEDS 55 LGVACVDMGGETCNLTIYSGNSIRY........NKYLPVGSHHLTTDLS........HMLNTPFP 56 LGVACVDMGGETCNLTIYSGNSIRY........NKYLPVGSHHLTTDLS........HMLNTPFP 57 LGAVLIDMGGAICDMVVHTGNSIRY........NDCLQIGSINITQDLS........MALHTPLK 58 QTTVVVDMGGGTTDIGVFKRGNLAH........SASIPIGGDHVTADLA........QILKIPME 59 FGTIMVDLGAGQTTVSIVKDQSLKF........THTSPEGGDYVTKDIS........TVLNTSVS 60 FGTIVIDMGGGQTTTSVIHDKQLKF........THVNQEGGEFITKDIS........IVLNTSFN 61 FGTIVIDMGGGQTTTAVMHDKQLKF........TSLDQEGGEFVTKDIS........IVLNTSFN 62 FGATVIDMGAGQTTVATIRNQELQF........THILQEGGDYVTKDIS........KVLKTSRK 63 LGVALIDIGGGSTTIAVFQNGHLTS........TRVIPLGGENITKDIS........IGLRTSTE 64 VGCVLINIGGGTTDVIAMYKGSPVL........ITSIPVGGSQVTSDLA........KVKNLPLE 65 MGVLFIDMGKGTTDIILYIDGSPYY........TGVIPIGVNRVTLDIA........QVWKVPED 66 -------------------------........----------------........-------- 67 MGVLFIDMGKGTTDIILYIDGSPYY........TGVIPIGVNRVTLDIA........QVWKVPED 68 LGVCVIDIGGGTTDIAVYMNGAIRH........TSVIPAGGNLITKDLS........KSLRTPLD 69 LGVCVIDIGGGTTDIAVYMNGAIRH........TSVIPAGGNLITKDLS........KSLRTPLD 70 LGVCLVDIGGGTTDIAIFTEGAIRH........TAVIPIAGDQVTNDIA........MALRTPTQ 71 LGVCLVDIGGGTTDIAIFTEGAIRH........TAVIPIAGDQVTNDIA........MALRTPTQ 72 LGVCLVDIGGGTTDIAIFTEGAIRH........TAVIPIAGDQVTNDIA........MALRTPTQ 73 LGVCMIDIGGGTIDLITYIDGSIQD........SQVIPYAGNIVTKDIS........YAFSTSYS 74 LGVCVVDIGGGTMDIAVYTGGALRH........TKVIPYAGNVVTSDIA........YAFGTPPS 75 LGVCVVDIGGGTMDIAVYTGGALRH........TKVIPYAGNVVTSDIA........YAFGTPPS 76 LGVCLIDFGAGTMNVMVYTNGALRF........SKVIPYAGNIVTNDIA........HACTISRA 77 LGAACIDLGGGTTTLSVFSEGKFVH........TDVLPVGGHHVTLDVA........RGFSMSIE 78 LGCAAIDMGGGTTTISVFAEGKLVH........ADAVGLGGHHVTTDLA........RGLSTRIE 79 LGCAAIDMGGGTTTISVFAEGRLIH........TDAIGLGGHHVTTDLA........RGLSTRIE 80 LGVALVELGAGVTNVSLFAGGLLVG........LTSIPMGASDITDDIA........AAFGTRRS 81 DGVLLLDMGAGLTDYSLYTEGRPYI........TGVVPFGGINITKDLS........YMLKIDTE 82 LGVLIIDIGDQTTSCGIFFADKLIY........TWHLNIGSFHISLDIA........KVFGIDLV 83 RGVVVVNLGYNFTGLIAYKNGVPIK........ISYVPVGMKHVIKDVS........AVLDTSFE 84 RGVVVVNLGYNFTGLIAYKNGVPIK........ISYVPVGMKHVIKDVS........AVLDTSFE 85 VANVVVDIGGGTTEVAIISFGGVVS........CHSIRIGGDQLDEDIVsfvrkk..YNLLIGER 86 QGSLIVDIGGGTTEIGVISLGGLVI........SKSIRVAGDKLDQSIVeyirkk..FNLLIGER 87 QGSLIVDIGGGTTEIGVISLGGLVI........SKSIRVAGDKLDQSIVeyirkk..FNLLIGER 88 QGSLIVDIGGGTTEIGVISLGGLVI........SKSIRVAGDKLDQSIVeyirkk..FNLLIGER 89 KGNLVVDIGGGTTEIGVISLGGLVI........SKSIRTAGDKLDMSIVnyvkek..YNLIIGER 90 TGHMVCDIGGGTTEISVISLGGMVV........SRAIRTGGDEFDESIIkymrns..HNIIIGQQ 91 AGNMVCDIGGGTTEVSVISLLGMVV........TNAIRVGGDEFDQAIIkhvrsv..HNLIIGEQ 92 TGSMVVDIGGGTTEVAIISLGGIVT........SQSIRVAGDEMDDAIInyirkt..YNLMIGDR 93 TGSMVVDIGGGTTEVAIISLGGIVT........SQSIRVAGDEMDDAIInyirkt..YNLMIGDR 94 TGNMVVDIGGGTTEVAVISLGGIVT........AQSIRVAGDELDNAIIqhvkke..YSLLLGER 95 TGNMVVDIGGGTTEVAVISLGGIVT........AS-PSVAGDELDNAIIqhvkke..YSLLLGER 96 SGNMVVDIGGGTTDIAVLSMGDIVT........SSSIKMAGDKFDMEILnyikrk..YKLLIGER 97 SGNMVVDIGGGTTDIAVISMGDIVT........SSSIKMAGDKFDMEILnyikre..YKLLIGER 98 SGNMVVDIGGGTTDIAVISMGDIVT........SSSIKMAGDKFDMEILnyikre..YKLLIGER 99 SGNMVVDIGGGTTDIAVISMGDIVT........SSSIKMAGDKFDMEILnyikre..YKLLIGER 260 270 280 290 300 | | | | | 1 QCERTKRTLSSST---QA......TIEIDSLFEG...IDY....S....VSISRARF.EELCMDY 2 QCERTKRTLSSST---QA......TIEIDSLFEG...IDY....S....VSISRARF.EELCMDY 3 QCERTKRTLSSST---QA......TIEIDSLFEG...IDY....S....VSISRARF.EELCMDY 4 QCERTKRTLSSST---QA......TIEIDSLFEG...IDY....S....VSISRARF.EELCMDY 5 HCERAKRVLSSST---QA......TIELDSLYEG...IDY....N....TTISRARF.EELCNEK 6 ACERAKALSSQT----QT......TIEIDSLFEG...IDF....N....ATITRAKF.EELNIDL 7 ACERAKRTLSSTA---QT......TIEIDSLYEG...IDF....Y....STITRARF.EELNMDL 8 ACERVKRTLSSSA---ST......NIAIDALYEG...FDF....F....SKITRARF.EEMCRDQ 9 ACERAKRTLSSVT---QT......MVEVDSLYQG...EDF....S....ASITRARF.EEINAVL 10 ACERAKRTLSSSS---EA......SIEIDSLYEG...IDF....Y....TKITRARF.EELCGDL 11 ACERAKRTLSSSS---EA......SIEIDSLYEG...IDF....Y....TKITRARF.EELCGDL 12 ACERAKRTLSSSS---EA......SIEIDSLFEG...IDY....Y....TKVSRARF.EELCGDL 13 ACERAKRTLSSSS---EA......SIEIDSLFEG...IDY....Y....TKVSRARF.EELCGDL 14 AFERAKRTLSSSS---QA......SIEIDSLFEG...VDF....Y....TSITRARF.EELCSDL 15 ACERAKRTLSSSA---QA......SIEIDSLYEG...IDF....Y....TSITRARF.EELCADL 16 ACERAKRTLSSAA---QT......SIEIDSLYDG...IDF....Y....TSITRARF.EELCQDL 17 ACERAKRTLSSAA---QT......SIEIDSLYEG...IDF....Y....TSITRARF.EELCQDL 18 ACERAKRTLSSAA---QT......SIEIDSLYEG...IDF....Y....TSITRARF.EELCQDL 19 ACERAKRTLSSAA---QT......SIEIDSLYEG...IDF....Y....TSITRARF.EELCQDL 20 ACERAKRTLSSAA---QT......SIEIDSLYEG...IDF....Y....TSITRARF.EELCQDL 21 ACERAKRTLSSSS---EA......CVEVDSLFEG...IDL....C....TKITRARF.EELCADL 22 ACERAKRTLSSST---EA......TVEVDSLFDG...TDF....Y....SKITRARF.EELCADL 23 EVEKAKRILSSQM---SA......RVDIESLYQG...IDF....S....ETLTRPKF.EEINMHL 24 EVEKAKRTLSSQM---SA......RVEIESLYQG...IDF....S....ETLTRAKF.EEINMHL 25 EAERAKRTLSVQQ---QD......RIEIENLADG...VDF....S....FTLTRAKF.EELNMDL 26 EAEKAKRALSSQM---ST......RIEIDSFVDG...IDL....S....ETLTRAKF.EELNLDL 27 EVEKAKRALSTQH---QT......KIEIESLFDG...EDF....S....ETLTRAKF.EELNMDL 28 EVEKAKRALSSSH---QV......KIEIESFFEG...DDS....S....ETLTRAKF.EELNMDL 29 EVEKAKALSSQH----QA......RIEIESFYEG...EDF....S....ETLTRAKF.EELNMDL 30 EVEKAKRALSSQH---QA......RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDL 31 EVEKAKRALSSQH---QA......RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDL 32 EVEKAKRALSSQH---QA......RIEIESFYEG...EDF....S....ETLTRAKF.EELNMDL 33 EVEKAKRALSSQH---QA......RIEIESFYEG...EDF....S....ETLTRAKF.EELNMDL 34 EVEKAKRALSSQH---QA......RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDL 35 EVEKAKRALSSQH---QA......RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDL 36 EVEKAKRALSSQH---QA......RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDL 37 EVEKAKRALSSQH---QA......RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDL 38 EVEIAKRNLSVVH---ST......QIEIEDILEG...HNF....S....ETLTRAKF.EELNDDL 39 EVEIAKRNLSVVH---ST......QIEIEDIVEG...HNF....S....ETLTRAKF.EELNDDL 40 EAEKAKHTLSTLP---QV......NIEIENFMDG...EDF....T....ETLTRARF.EEINNDL 41 ACERAKRTLSSSA---QA......SIEIDALYEG...IDF....Y....TTLTKPRF.EELNNDL 42 AAEKGKKELSSSQQTDIN......PPFITADASGa..KHL....Q....MSITRAEF.ERLCDPL 43 EPSRAKVELSSAMETEIQ......LPFITADASGp..KHL....V....MKLTRAKF.EALVEPL 44 AAEKAKMELSSVMETEINl.....PFIIADASGP...KHL....T....MKLTRARF.EQLVEDL 45 AAEKAKIELSGTMSTQINl.....PFITAEPSRP...KHL....E....LTLTRAKFdQDLTKSL 46 AAEKAKIELSSSLQTDIN......LPYLTMDKAGp..KHM....H....LKLTRAKL.EHLVEPL 47 AAEKAKIELSSTTQTEIN......LPFITADQTGp..KHL....T....MKLTRAKF.EALVDDL 48 AAEKAKIELSSTSQTDIN......LPFITADASGa..KHL....N....ITLTRSKF.ETLVNNL 49 AAEKAKIELSSTSQTDIN......LPFITADASGa..KHL....N....ITLTRSKF.ETLVNHL 50 EAGRLKNVLSANT---EF......FAQIENLIED...IDF....K....LPVTREKL.EQLCEDL 51 TAEHVKRTVFSEERVKVK......NI--------...LDR....E....IELNVREV.SEAIKPV 52 ----LKKLNTNMVMHSMI......LLQIKISSLL...NRL....IvmkqYSIPQKDL.SDFIEAR 53 EAENMKLNHVSMINDNKS......NGSFRMTFAD...KFS....E....REFRSSEV.NRLAKAR 54 DAEKMKIKYASAF--TEN......NEIDNTLSYS...IDA....D....RQIESRKF.IEIVEGR 55 YAEEVKIKYGDLSFESGAetpsq.SVQIPTTGSD...GHE....S....HIVPLSEI.QTIMRER 56 YAEEVKIKYGDLSFEGGEetpsq.NVQIPTTGSD...GHE....S....HIVPLSEI.QTIMRER 57 EAEKIKLNYAALS--QQP......NTLIQIPSMGd..ERK....V....NEVSLDII.SNVIYAR 58 EAEKVKRHYGAAIPELAD......QELTLEITTA...SGA....T....HAISAYEL.SRVIRPR 59 AAEDLKVNYGEASTERASq.....DEYFLVDVVG...KDE....P....EQITEYYL.SQIIEAR 60 NAEALKINYGDAYPERTSa.....NEEFPVDVIG...KSE....P....VRVDERYL.SEIIEAR 61 NAEALKINYGDAYPERTSa.....NEEFPVDVIG...QSE....P....VKVDERYL.SEVISAR 62 LAEGLKLNYGEAYPPLAS......KETFQVEVIG...EVE....A....VEVTEAYL.SEIISAR 63 EAERVKKQLGHAYYDEASe.....DEIFEVTVIG...TNQ....K....QTFTQQEA.ANIIEAR 64 TAERIKIKDGCCWIPLLEg.....EGSVLISSQG...NRI....P....VEISKREI.AEIIEAR 65 VAENIKITAGIAHPSILEsq....METVIIPNLG...TRP....P....QEKSRKEL.SVIINSR 66 ------------------......----------...---....P....QEKSRKEL.SVIINSR 67 VAENIKITAGIAHPSILEsq....METVIIPNLG...TRP....P....QEKSRKEL.SVIINSR 68 AAEYIKIHYGVASCDTEGl.....GEMIEVPGVG...DRT....S....RQVSSKVL.AAIISAR 69 AAEYIKIHYGVASCDTEGl.....GEMIEVPGVG...DRT....S....RQVSSKVL.AAIISAR 70 YAEEIKIRYACALAKLAGa.....GETIKVPTVG...DRP....P....GELSRQAL.AEVVEPR 71 YAEEIKIRYACALAKLAGa.....GETIKVPSVG...DRP....P....RELSRQAL.AEVVEPR 72 YAEEIKIRYTCALAKLAGa.....GETIKVPSVG...DRP....P....RELSRQAL.AEVVEPR 73 DSEKIKIKYGSAIKLSPGt.....SKNIDLSSKY...GNF....Q....KNLQQDTV.IEVIDSR 74 DAEAIKVRHGCALGSIVGk.....DESVEVPSVG...GRP....P....RSLQRQTL.AEVIEPR 75 DAEAIKVRHGCALGSIVGk.....DESVEVPSVG...GRP....P....RSLQRQTL.AEVIEPR 76 EAERIKVNYASAFYPARLhg....DKKIEVASIG...GRA....P....RSLTKSDL.SLITSAR 77 EAERLKIVYGSTFSMSADd.....RCMINVLEIGn..GHH....E....TEYPRAVL.GRIIRAR 78 DAERLKVVHGSALPNSADe.....RDIISVPPIGeddRDQ....P....THVPRALV.SRIVRAR 79 DAERLKVVHGSALLNGADe.....RDMISIPPIGeddRDQ....P....SQVSRALV.TRIVRAR 80 DAERLKCFYGSAQSSPRDn.....HEMIDVAPIA...NDEdvidP....QRISRAQL.IGVIRKR 81 TAESVKVNHGVAFESLVDd.....EDVVKIKPRG...EDR....E....IPIQKKQV.AEIIQSR 82 TAEKLKILYGNAIIPLFEkds...IINMDDFHVDip.HNL....N....ISLTIYRL.AEVISAR 83 ESERLIITHGNAVYNDLK......EEEIQYRGLD...GNT....I....KTTTAKKL.SVIIHAR 84 ESERLIITHGNAVYNDLK......EEEIQYRGLD...GNT....I....KTTTAKKL.SVIIHAR 85 TAEQVKMEIGHALIEHIPeam...EIRGRDLVTG...LPK....T....IMLQSNEI.QDAMRES 86 TGEEIKIEIGCAIKLDPPltm...EVSGRDQVSG...LLH....T....IELSSDDV.FEAIKNQ 87 TGEEIKIEIGCAIKLDPPltm...EVSGRDQVSG...LLH....T....IELSSDDV.FEAIKDQ 88 TGEEIKIEIGCAIKLDPPltm...EVSGRDQVSG...LLH....T....IELSSDDV.FEAIKDQ 89 TGEEIKITIGSAIQLPKElsm...VVKGRDQVSG...LLS....R....IELTSEDV.REAMREY 90 TAEKLKIKIGNVYPDIQNlrvekiDIKGTDAVTG...LPR....K....QLVDSMEV.RESLQEP 91 TAERLKIEIGNASPEKNIekv...EVKGTDAITG...LPR....R....LEIDSVEV.REALKEP 92 TAEAIKMEIGSAEAPEESdnm...EIRGRDLLTG...LPK....T....IEITGKEI.SNALRDT 93 TAEAIKMEIGSAEAPEESdnm...EIRGRDLLTG...LPK....T....IEITGKEI.SNALRDT 94 TAEQIKITIGSAYDLDSDeht...EIRGRDLVSG...LPK....T....VVISAAEV.RKAIEEP 95 TAEQIKITIGSAYDLDSDeht...EIRGRDLVSG...LPK....T....VVISAAEV.RKAIEEP 96 TSEDIKIKVGTVFPGARSeel...EIRGRDMVTG...LPR....T....ITVCSEEI.TEALKEN 97 TAEDIKIKVATVFPDARHeei...SIRGRDMVSG...LPR....T....ITVNSKEV.EEALRES 98 TAEDIKIKVATVFPDARHeei...SIRGRDMVSG...LPR....T....ITVNSKEV.EEALRES 99 TAEDIKIKVATVFPDARHeei...SIRGRDMVSG...LPR....T....ITVNSKEV.EEALRES 310 320 330 340 350 360 | | | | | | 1 FRNSLLP.VEKVLKD.SGI------.DKRSVSEVVLVGGSTRIPKIQQLITDFF.NGK.EPCR-- 2 FRNSLLP.VEKVLKD.SGI------.DKRSVSEVVLVGGSTRIPKIQQLITDFF.NGK.EPCR-- 3 FRNSLLP.VEKVLKD.SGI------.DKRSVSEVVLVGGSTRIPKIQQLITDFF.NGK.EPCR-- 4 FRNSLLP.VEKVLKD.SGI------.DKRSVSEVVLVGGSTRIPKIQQLITDFF.NGK.EPCR-- 5 FRSTLVP.VEKALES.SGL------.DKRSIHEVVLVGGSTRIPKIQSLIKSFF.NGK.EPCR-- 6 FRGCLEP.VEKVLRD.AKV------.DKGTIHDIVLVGGSSRIPKVQQLLRDFF.NGK.ELCQ-- 7 FRKCMEP.VEKCLRD.AKM------.DKSTVHDVVLVGGSTRIPRVQQLLQDFF.NGK.ELCK-- 8 FERCLEP.VRKVLKD.AEV------.DASAVDDVVLVGGSTRIPRVQQLVQNFF.N--.------ 9 FKSTLEP.VEKVLKD.AKM------.AHEKVDDIVLVGGSTRIPKVQALVSEYFgGRQ.LNKS-- 10 FRSTLQP.VETALRD.AKL------.DKGKIDEVVLVGGSTRIPKVQKLLTDFFnGKE.LNKS-- 11 FRSTLQP.VETALRD.AKL------.DKGKIDEVVLVGGSTRIPKVQKLLTDFFnGKE.LNKS-- 12 FRNTLEP.VETALRD.AKL------.DKGKIDEVVLVGGSTRIPKIQKLLTDFFnGKE.LNKS-- 13 FRNTLEP.VETALRD.AKL------.DKGKIDEVVLVGGSTRIPKIQKLLTDFF.N--.------ 14 FRGTLEP.VEKSLRD.AKL------.DKGQIHDVVLVGGSTRIPKIQKLLQDFFnGRE.LNKS-- 15 FRNTMEP.VEKVLRD.SKI------.DKSSVNEIVLVGGSTRIPRIQKLVSDFF.NGK.EPCK-- 16 FRSTMEP.VEKVLRD.SKI------.DKSSVNEIVLVGGSTRIPKIQKLVSDMFsGRE.PNRS-- 17 FRSTMEP.VERVLRD.AKI------.DKSSVHEIVLVGGSTRIPRIQKLVSDFFnGKE.PNKS-- 18 FRSTMDP.VERVLRD.AKI------.DKSSVHEIVLVGGSTRIPRIQKLVSDFFnGKE.PNKS-- 19 FRSTMDP.VERVVRD.AKI------.DKSSVHEIVLVGGSTRIPRIQKLVSDFFnGKE.PNKS-- 20 FRSTMDP.VERVLRD.AKI------.DKSSVHEIVLVGGSTRIPRIQKLVSDFFnGKE.PNKS-- 21 FRKTLEP.VEKALRD.AKL------.DKSKIDEVVLVGGSTRVPKIQKLLKDFFnGKE.LNCS-- 22 FRKTLEP.VEKALRD.AKT------.DKGRIDEVVLVGGSTRIPKIQKLLKEFFnGKD.LNCS-- 23 SKKTMKP.VEQVLKD.GNV------.KKSDIDDIVLVGGSTRIPKVQQLLEDYFdGKK.VSKS-- 24 FKKTMKP.VEQVLKD.GNV------.KKSDIDDIVLVGGSTRIPKVQQLLEEFFdGKK.VSKS-- 25 FKSTIAP.VKKVLED.SKM------.SKGAIHEVVLVGGSTRIPKVQQLLKEFFnGKE.PSRG-- 26 FKKTLKP.VEKVLQD.SGL------.EKKDVDDIVLVGGSTRIPKVQQLLESYFdGKK.ASKG-- 27 FRATLKP.VQKVLED.ADM------.KKTDVHEIVLVGGSTRIPKVQQLIKDYFnGKE.PSRG-- 28 FRSTLKP.VQKVLED.ADM------.NKKDVDEIVLVGGSTRIPKVQQLVKEFFnGKE.PSRG-- 29 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 30 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 31 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 32 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 33 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 34 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 35 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 36 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 37 FRSTMKP.VQKVLED.SDL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-- 38 FRETLEP.VKKVLDD.AKY------.EKSKIDEIVLVGGSTRIPKIQQIIKEFFnGKE.PNRG-- 39 FRETLEP.VKKVLDD.AKY------.EKSKIDEIVLVGGSTRIPKIQQIIKEFFnGKE.PNRG-- 40 FKKCMGP.VDQVLKD.AGL------.SKSEIDDVVLVGGSTRIPKVQQLVKSFFnGKE.PSKA-- 41 FKKTTEC.VEKAVRD.AKM------.EKGEIHEIVLVGGSTRIPKIQKLLEDFFkGKS.LNKS-- 42 FERCREP.VTKALKD.AKL------.DPKEIDEVVLVGGSTRIPKVQELVREMF.GKE.PHKG-- 43 LKRLMPP.VEQAIKD.AGL------.EPKDIEEIVLVGGSTRIPKVQEMVKGFF.GKE.PNKS-- 44 LQKSVGP.CKQALSD.AGV------.KPEQIDEVVLVGGSTRIPRVQQIVRDLF.KKE.PHKG-- 45 VDRTRIP.CEKHLRD.AGL------.KASDINEVILVGGGLRIPAVQELVKQVF.GKE.PNKS-- 46 IKRTIDP.CNKALKD.AEV------.KASDIGEIILVGGMTRMPKVQETVEKIF.GKT.PSKS-- 47 IQKTVEP.CRKALKD.AGV------.TAGEIGEVVLVGGMSRMPKVQEVVKQLF.GKE.PHKG-- 48 IERTRNP.CKNCLKD.AGV------.SLKDVDEVLLVGGMTRVPKVQEIVSEIF.GKS.PSKG-- 49 IERTRNP.CKNCLKD.AGV------.SLKDVDEVLLVGGMTRVPKVQEIVSEIF.GKS.PSKG-- 50 WPRATKP.LEEALAS.SHL------.SLDVINQVILFGGGTRVPRVQETIKAVI.KQE.LGKN-- 51 VDQITTE.ISTVVTE.LNG------.--GAPSVVMVVGGGAKVPGFVESLARKL.DLPlDRVSLK 52 VEEIFFE.VFDVLQD.LGL------.-TKVNGGFIVTGGSANLLGVKELLSDMV.SEK.VRIH-- 53 MDEITAN.YLNILRL.SGL------.LEDIGAGIILNGGGTKINNYMAAMKKIL.G--.------ 54 VEEI---.----IEN.AWFQVPNEY.ADKLLGGIILTGGGSNMPNIEKAFRSHT.HIE.------ 55 ALETFKI.IHRSIQD.SGF------.EEHLGGGVVLTGGMALMKGIKELARTHFtNYP.VRLA-- 56 ALETFKI.IHRSIQD.SGL------.EEHLGGGVVLTGGMALMKGIKELARTHFtNYP.VRLA-- 57 AEETLMI.LAKILSD.NRY------.ANAIGGGVVLTGGMTKLAGIDELAPATFdNRS.VRLA-- 58 VSEIYGL.IRDEIDQaLGP------.VELVAQSVVLTGGGAQLPGAVDLARERF.RLP.TRLG-- 59 MTQVFNR.VRQDLEH.GHT------.-SETPGGLILVGGTAAMPGVVDLATKIL.GMN.ARLY-- 60 VEQILRK.SKEVLDE.IDA------.-FELPGGVVLTGGAASIARYCRFRRKRFlEAN.VKLY-- 61 MEQIFNK.AKEALDQ.IEA------.-LELPGGIVLTGGAASLPGVVDLAQEIF.GVN.VKLY-- 62 IKHILEQ.IKQELDR.RRL------.-LDLPGGIVLIGGNAILPGMVELAQEVF.GVR.VKLY-- 63 VEEILEI.VSEELRS.MGI------.-TDLPGGFVLTGGQAAMPGVMSLAQDVL.QNN.VRVQ-- 64 MCEVFTI.VRDRLST.VET----QS.GRGIIENIILCGGGAQLTGAVELASAIF.DTPrVHLG-- 65 LREIFEM.MKAEILK.RGL------.YNKINGGIVLTGGGALFPGISNLIEEVF.NYP.ARIG-- 66 LREIFEM.MKAEILK.RGL------.YNKINGGIVLTGGGALFPGISNLIEEVF.NYP.ARIG-- 67 LREIFEM.MKAEILK.RGL------.YNKINGGIVLTGGGALFPGISNLIEEVF.NYP.ARIG-- 68 IQEIFGV.VLGELQK.SGF-----P.KEVLNAGIVLTGGVSMMTGIVEFAEKIF.DLP.VRTG-- 69 IQEIFGV.VLGELQK.SGF-----P.KEVLNAGIVLTGGVSMMTGIVEFAEKIF.DLP.VRTG-- 70 YDELFTL.VQAELRR.SGY------.EDLIPAGIVLTGGTSKMEGAVELAEEIF.HMP.VRLG-- 71 YDELFTL.VQAELRR.SGY------.EDLIPAGIVLTGGTSKMEGAVELAEEIF.HMP.VRLG-- 72 YDELFTL.IQAELRR.SGY------.EDLVPAGIVLTGGTAKMEGAVELAEEIF.HMP.VRLG-- 73 YNELLHL.INNRILY.VQKKLYKEGrKYQLTGGIVLTGGASTISFLTECAEKIF.QKK.IRIA-- 74 YTELLNL.VNEEILQ.LQEKLRQQGvKHHLAAGIVLTGGAAQIEGLAACAQRVF.HTQ.VRIG-- 75 YTELLNL.VNEEILQ.LQEKLRQQGvKHHLAAGIVLTGGARQIEGLAACAQRVF.HTQ.VRIG-- 76 YTELLGV.VKDELDK.LKAELEAKHiKFELIAGVVITGGGAQIEDLKECASNVF.HCQ.VRIA-- 77 VEEILEM.MRDRLNR.SGF------.GHIIGKRVILTGGASQLTGLPEMARNIL.GRN.VRIG-- 78 IEETLEL.IRDRIQR.SGF------.SPIVGKRIVLTGGASQLTGLPEAARRIL.ARN.VRIG-- 79 IEETLEL.IRDRIQK.SGF------.SPIVGKRVVLTGGASQLTGLPETARRIL.ARN.VRIG-- 80 LDHWMDH.IADALKS.LGY------.NGPVGRQVVLTGGGAELKGIADYAQGVL.GRS.VRIG-- 81 VEEIVEK.VFKEIKA.RGV-----P.LNQINSGIVVTGGTANLKGIRELIEHMT.GLP.VRIG-- 82 AEEILSM.VKAEYDK.ATK------.GQFEVFRVVITGGGSQLRGLKELSNKIF.AKQ.SRIG-- 83 LREIMSK.SKKFFRE.VEAKIVEEG.EIGIPGGVVLTGGGAKIPRINELATEVF.KSP.VRTGCY 84 LREIMSK.SKKFFRE.VEAKIVEEG.EIGIPGGVVLTGGGAKIPRINELATEVF.KSP.VRTGCY 85 LLHILEA.IRATLED.CPP---ELS.GDIVDRGVILTGGGALLNGIKEWLTEEI.VVP.VHVA-- 86 VREISSA.LRSVLEE.VKP---DLV.KDIVQNGVVLTGGGALIKGLDKYLSDMV.KLP.VYVG-- 87 VREISSA.LRSVLEE.VKP---DLV.RDIVQNGVVLTGGGALIKGLDKYLSDMV.KLP.VYVG-- 88 VREISSA.LRSVLEE.VKP---DLA.KDIVQNGVVLTGGGALIKGLDKYLSDMV.KLP.VYVG-- 89 LKEIADA.LKMVLEM.MPP---DLA.SDIVENGVVLTGGGALIRGLDKYLSEIV.RLP.VYIA-- 90 INVVVDE.VKRTLGA.TPP---ELA.TDIVERGIILTGGGALLKGLNRLLSKET.GVP.VYVA-- 91 ITQIVEE.IKRTLAR.TPP---ELA.ADIVERGIVMTGGGSLLKGLPKLISKET.HVP.VILA-- 92 VSTIVEA.VKSTLEK.TPP---ELA.ADIMDRGIVLTGGGALLRNLDKVISEET.KMP.VLIA-- 93 VSTIVEA.VKSTLEK.TPP---ELA.ADIMDRGIVLTGGGALLRNLDKVISEET.KMP.VLIA-- 94 VNAIVDA.VKTTLDK.CPP---ELS.GDIMDRGIVLTGGGALLRGLDERLRRET.GMP.IHIA-- 95 VNAIVDAgSRTTLDK.CPP---ELS.GDIMDRGIVLTGGGALLPGLDERLRRET.GMP.IHIA-- 96 AAVIVQA.AKGVLER.TPP---ELS.ADIIDRGVILTGGGALLHGIDMLLAEEL.KVP.VLIA-- 97 VAVIVQA.AKQVLER.TPP---ELS.ADIIDRGVIITGGGALLNGLDQLLAEEL.KVP.VLVA-- 98 VAVIVQA.AKQVLER.TPP---ELS.ADIIDRGVIITGGGALLNGLDQLLAEEL.KVP.------ 99 VAVIVQA.AKQVLER.TPP---ELS.ADIIDRGVIITGGGALLNGLDQLLAEE-.---.------ 370 380 390 400 | | | | 1 --------------SINPDEAVAYGAA.....-----.....----.......-------.---. 2 --------------SINPDEAVAYGAA.....-----.....----.......-------.---. 3 --------------SINPDEAVAYGAA.....-----.....----.......-------.---. 4 --------------SINPDEAVAYGAA.....-----.....----.......-------.---. 5 --------------SINPDEAVAYGAA.....VQ---.....----.......-------.---. 6 --------------SINPDEAVAYGAV.....QAA--.....----.......-------.---. 7 --------------NINPDEAVAYGAA.....VQ---.....----.......-------.---. 8 ---------------------------.....-----.....----.......-------.---. 9 ---------------INP---------.....-----.....----.......-------.---. 10 ---------------INPDEAVAYGAA.....V----.....----.......-------.---. 11 ---------------INPDEAVAYGAA.....V----.....----.......-------.---. 12 ---------------INPDE-------.....-----.....----.......-------.---. 13 ---------------------------.....-----.....----.......-------.---. 14 ---------------INPDEAVAYGAA.....V----.....----.......-------.---. 15 --------------SINPDEAVAYGAA.....VQ---.....----.......-------.---. 16 ---------------INPDEAVAYGAA.....V----.....----.......-------.---. 17 ---------------INPDEAVAYGAA.....VQAA-.....----.......-------.---. 18 ---------------INPDEAVAYGAA.....VQAA-.....----.......-------.---. 19 ---------------INPDEAVAYGAA.....VQAAI.....----.......-------.---. 20 ---------------INPDEAVAYGAA.....VQAA-.....----.......-------.---. 21 ---------------INPDEAVAFGAA.....-----.....----.......-------.---. 22 ---------------INPDEAVAFGAA.....-----.....----.......-------.---. 23 ---------------INPAEAVAYGAT.....-----.....----.......-------.---. 24 ---------------INPDEAVAYGAT.....-----.....----.......-------.---. 25 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 26 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 27 ---------------INPDEAVAYGA-.....-----.....----.......-------.---. 28 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 29 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 30 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 31 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 32 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 33 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 34 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 35 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 36 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 37 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 38 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 39 ---------------INPDEAVAYGAA.....-----.....----.......-------.---. 40 ---------------VNPDEAVAHGAA.....VQA--.....----.......-------.---. 41 ---------------INPDEAVAYGAA.....VQ---.....----.......-------.---. 42 ---------------VNPDEAV-----.....-----.....----.......-------.---. 43 ---------------VNPDEAV-----.....-----.....----.......-------.---. 44 ---------------VNPDEAV-----.....-----.....----.......-------.---. 45 ---------------VNPDEVVAIGAA.....-----.....----.......-------.---. 46 ---------------VNPDEAVAMGAA.....I----.....----.......-------.---. 47 ---------------VNPDEVVAIGAA.....-----.....----.......-------.---. 48 ---------------VNPDEAVAMGAA.....L----.....----.......-------.---. 49 ---------------VNPDEAVAMGAA.....L----.....----.......-------.---. 50 ---------------LNADESATMGAV.....Y----.....----.......-------.---. 51 SVESTGLVEDLTGKVKGSEYITPVGIA.....YSAMR.....----.......-------.---. 52 ----TPSQMGI----RKPEFSSAISTIsssiaFDELL.....DYVT.......INYHDNE.ETE. 53 ---------------------------.....-----.....----.......-------.---. 54 ---------------------------.....-----.....----.......-------.---. 55 TPVEKYNIMGMFEDLKDPRFSVVVGLI.....LYKAG.....GHTN.......YERDS--.---. 56 APVEKYNIMGMFEDLKDPRFSVVVGLI.....LYKAG.....GHTN.......YERDSK-.---. 57 -TARKDLITGFSEIFNDPENTCAIGLC.....LYGAG.....YFTP.......YELDSNE.KL-. 58 ---RPRGIHGLSDIVGDPAHACSVGMV.....LYGI-.....----.......-------.---. 59 ----VPGEMGL----RNPAFAQVISVV.....-----.....----.......-------.---. 60 ----VPNHMGL----RNPVFANVISIV.....EYS--.....----.......-------.---. 61 ----VPNQMGL----RNPVFTNVISIV.....DY---.....----.......-------.---. 62 ----VPNQVGI----RNPAFAHVIS--.....-----.....----.......-------.---. 63 ----GPNYIGV----RDPQYMTGVGLI.....QFACR.....----.......-------.---. 64 ---IPGTLGGLAGEYRSPEFAVVLGLI.....LEYTH.....K---.......-------.---. 65 ---LPMSINGIGEEHIDPKFSSALGLV.....LYKHE.....QQ--.......-------.---. 66 ---LPMSINGIGEEHIDPKFSSALGLV.....LYKHE.....QQ--.......-------.---. 67 ---LPMSINGIGEEHIDPKFSSALGLV.....LYKHE.....QQ--.......-------.---. 68 ---APQEMGGLSDRVRTPRFSTAIGLL.....HAACKlegnlPQLE.......NGAVQER.EGG. 69 ---APQEMGGLSDRVRTPRFSTAIGLL.....HAACKlegnlPQPE.......NGAVQER.EGG. 70 ---VPYSVKGLTDVVRNPIYSTGVGLL.....MYGLQ.....KQSDgmsmsvsGSSYSSD.EPK. 71 ---VPYSVKGLTDVVRNPIYSTGVGLL.....MYGLQ.....KQSDgmsmsvsGSSYSSD.EPK. 72 ---VPHSVRGLSDVVRNPIYSTGVGLL.....TYGLL.....KQSE.......DLA----.---. 73 ---KPLNISGLTDNVTEPHYSTVVGLL.....HYGKE.....FYFD.......DTNQKREiSFI. 74 ---APLNITGLTDYAQEPYYSTAVGLL.....HYGKE.....SHLN.......GEAEVEK.RVT. 75 ---APLNITGLTDYAQEPYYSTAVGLL.....HYGKE.....SHLN.......GEAEVEK.RVT. 76 ---SPLNITGLTDYVNRPQYSTVVGLL.....QYNYS.....NSDD.......DLISGSD.DSE. 77 ---RPLGISRLPSFAKGATFSSAVGLL.....IYPQL.....VGFE.......KK-----.---. 78 ---RPLGVSGLPAAAKGPAFSTAVGLM.....IYPQV.....ADLE.......THA----.---. 79 ---RPMGVAGLPVAAKGPAFSTACGLM.....IYPQV.....ADIE.......IHA----.---. 80 ---RPHGLVGLPDAHSGPAFATLTGLV.....LHAAS.....EPFD.......LRPLSYN.NRIg 81 ---LPQGIVGLREKIENPKYATVCGLLrqaf.VSGTI.....DITE.......STNSNTG.NFF. 82 ---KPEIIAGFTEDYNPAMYSAAIGMLkiha.LKQQK.....ALSH.......IRLDENI.NFF. 83 ANSDRPSIINADEVANDPSFAAAFGNV.....FAVSE.....NPYE.......ETPVKSE.NPL. 84 ANSDRPSIINADEVANDPSFAAAFGNV.....FAVSE.....NPYE.......ETPVKSE.NPL. 85 ---------------QNPLESVAIG--.....-----.....----.......-------.---. 86 ---------------DEPLLAVAKG--.....-----.....----.......-------.---. 87 ---------------DEPLLAVAKG--.....-----.....----.......-------.---. 88 ---------------DEPLLAVAKG--.....-----.....----.......-------.---. 89 ---------------DEPLLAVAKG--.....-----.....----.......-------.---. 90 ---------------DNPLLSVAVGA-.....-----.....----.......-------.---. 91 ---------------ENPMNCVAIG--.....-----.....----.......-------.---. 92 ---------------EDPLDCVAIG--.....-----.....----.......-------.---. 93 ---------------EDPLDCVAIG--.....-----.....----.......-------.---. 94 ---------------EDPLDSVALG--.....-----.....----.......-------.---. 95 ---------------EDPLDSVALG--.....-----.....----.......-------.---. 96 ---------------ENPMHCVAVG--.....-----.....----.......-------.---. 97 ---------------ENPMDCVAIG--.....-----.....----.......-------.---. 98 ---------------------------.....-----.....----.......-------.---. 99 ---------------------------.....-----.....----.......-------.---. 410 | 1 ..------------ 2 ..------------ 3 ..------------ 4 ..------------ 5 ..------------ 6 ..------------ 7 ..------------ 8 ..------------ 9 ..------------ 10 ..------------ 11 ..------------ 12 ..------------ 13 ..------------ 14 ..------------ 15 ..------------ 16 ..------------ 17 ..------------ 18 ..------------ 19 ..------------ 20 ..------------ 21 ..------------ 22 ..------------ 23 ..------------ 24 ..------------ 25 ..------------ 26 ..------------ 27 ..------------ 28 ..------------ 29 ..------------ 30 ..------------ 31 ..------------ 32 ..------------ 33 ..------------ 34 ..------------ 35 ..------------ 36 ..------------ 37 ..------------ 38 ..------------ 39 ..------------ 40 ..------------ 41 ..------------ 42 ..------------ 43 ..------------ 44 ..------------ 45 ..------------ 46 ..------------ 47 ..------------ 48 ..------------ 49 ..------------ 50 ..------------ 51 ..------------ 52 ..EDVIDVKDK--- 53 ..------------ 54 ..------------ 55 ..------------ 56 ..------------ 57 ..------------ 58 ..------------ 59 ..------------ 60 ..------------ 61 ..------------ 62 ..------------ 63 ..------------ 64 ..------------ 65 ..------------ 66 ..------------ 67 ..------------ 68 ..GGLLARLKRWIE 69 ..GGLLARLKRWIE 70 ..APVLERLKRWV- 71 ..APVLERLKRWV- 72 ..------------ 73 ..EKWFQKISNWF- 74 ..ASVGSWIKRL-- 75 ..ASVGSWIKRL-- 76 ..GTFFES------ 77 ..------------ 78 ..------------ 79 ..------------ 80 sqKSFMG------- 81 ..KNLSERFKKWFE 82 ..KKAFDWFKE--- 83 ..KKIFRLFKELME 84 ..KKIFRLFKELME 85 ..------------ 86 ..------------ 87 ..------------ 88 ..------------ 89 ..------------ 90 ..------------ 91 ..------------ 92 ..------------ 93 ..------------ 94 ..------------ 95 ..------------ 96 ..------------ 97 ..------------ 98 ..------------ 99 ..------------