Citations (SAM, SAM-T99, HMMs)
10 20 30 40 50
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1 MIDLSKTVFYTSIDIGSRYIKGLVLGK.....R..DQEWEALAF.SS.....VKSRGLDEGEIKD
2 MASVQSGKMIVGLDIGTSKVVALVGEV.....Ta.DGQLEVVGI.GT.....HPSRGLKKGVVVN
3 MANAHSGKMIVGLDIGTSKVVALVGEV.....Ge.DGTLEIVGI.GT.....HPSRGLKKGVVVN
4 MIKATDRKLVVGLEIGTAKVAALVGEV.....Lp.DGMVNIIGV.GS.....CPSRGMDKGGVND
5 MIKATDRKLVVGLEIGTAKVAALVGEV.....Lp.DGMVNIIGV.GS.....CPSRGMDKGGVND
6 -----QQRYISVLDIGTSKVLALIGEV.....Qd.DDKINIVGL.GQ.....APSRGLRAGMVTN
7 -----QQRYISVLDIGTSKVLALIGEV.....Qd.DDKINIVGL.GQ.....APSRGLRAGMVTN
8 MIISKNRKLVVGLEIGTTKVVTLVGEV.....Lt.NGKIKIIGI.GI.....CQSNGIDKGRIND
9 MVKGVETKTIVGLEVGTSKVVVVVGEV.....Fp.DGVVNVLGV.GS.....CPSKGIDRGSITD
10 ----NNNELYVSLDLGTSNTKVIVGEM.....T..GDSLNIIGV.GN.....VPSEGLKKGSIVD
11 -LPSKRSHVVSVLDIGSTKVVCMIGRLt11pgR..THSIEVIGI.GH.....QKSRGVKNGVIAD
12 ---MRENSIIVGLDIGTTKITTVIGEV.....Ap.DGTIDIIGE.GS.....VPSEGMKRGSVIN
13 MIDLSKTVFYTSIDIGSRYIKGLVLGK.....R..DQEWEALAF.SS.....VKSRGLDEGEIKD
14 -LSSKRSHIVSVLDIGSTKVVCMIGRLt11pgR..THKVEIIGI.GH.....QRSRGVKSGVIAD
15 ----------AALDIGSQKTVFVIGER.....Ds.YGDIHIIGF.GE.....VPSRGIVKGVIND
16 ------RNLIVGLDVGTSKICTVVAEV.....Nl.NDQLEIVGI.GT.....SISRGVRKGVLIN
17 ------RNLIVGLDVGTSKICTVVAEV.....Nl.NDQLEIVGI.GT.....SISRGVRKGVLIN
18 --GWRKTRFLTVLDVGSSKIVCLIACLh11ygR..THSIEILGF.GM.....QRSCGIKSGVIMD
19 ----AREGFFTGLDIGTSSVKVLVAEQ.....R..NGELNVIGV.SN.....AKSKGVKDGIIVD
20 ----EHKEIVIGVDIGSRKICAIVAEF.....K..DGILRIIGT.AHqdskeINSKAIKRGRINS
21 ----AKTGMYVGLDIGTTSVKVVVAEY.....I..DSQMNIIGV.GN.....AKSEGINRGIIVD
22 ----EHKEIVIGVDLGSRKICAIVAEF.....K..EGILRIIGT.AHqdskeINSKAIKRGRINS
23 MTPVKEGNLITALDIGSSKISALIVEK.....Ra.DNVLQVLGS.GQ.....RESLGVRRGYLFD
24 -------EVIVGLDIGTESIRAVVAER.....Le.GGALQVVGV.GV.....GHSKGLRRGVVVN
25 ---------ILGIDLGSTQTCAIIAQK.....D..EDGLKIIGF.SK.....SKTNGVKKGAITN
26 ----AKSGLYTGVDIGTNTIKVLVAEY.....V..SGEMNIIGV.GN.....AKSDGLKNGIIVD
27 -------SNFVTFDFGSSKIAVIAAYI.....Sk.KGEIKVASQ.NL.....HHSKGIKSGVILD
28 ---------------------------.....-..----NIIGV.GN.....AKSDGLNRGIVVD
29 ----------VGIDLGTTYSCVGIFR-.....-..DDRIEIIAN.DQg20gdAAKNQVAMNPANT
30 ----------IGIDLGTANVLIHVKGK.....GivLNEPSVVAL.DKn23niVAIRPLKDGVIAD
31 ---------DMAVDLGTANTLVYVRGR.....GivLNEPSVVAI.NTn23niVAVRPLKDGVIAD
32 ---------DIAIDLGTANTIVLVKGQ.....GiiINEPSIVAV.RMg28siRAIRPMKDGVIAD
33 ---------DIAIDLGTANTIVLVKGQ.....GiiINEPSIVAV.RMg28siRAIRPMKDGVIAD
34 ---------DIAIDLGTANTIVLVKGQ.....GiiINEPSIVAV.RMg28siRAIRPMKDGVIAD
35 ----------IGIDLGTTYSCVGIFR-.....-..DDRIEIIAN.EQg32qt-------------
36 MFFLRRFSADVGIDLGTCNTIIYVEGR.....GivVNEPSVVAV.ERg23niVAIRPLKDGVIAD
37 ----EDVGTVVGIDLGTTYSCVGVFK-.....-..NGRVEIIAN.DQg21gdAAKNQLTSNPENT
38 ------EHYYVSIDIGSSSVKTIVGEK.....F..HNGINVIGT.GQ.....TYTSGIKNGLIDD
39 ----EDVGTVVGIDLGTTYSCVGVFK-.....-..NGRVEIIAN.DQg21gdAAKNQLTSNPENT
40 ----------LGIDLGTANTLVFVKGK.....GivVREPSVVAL.QTd23nvVALRPMKDGVIAD
41 ----EDVGTVVGIDLGTTYSCVGVFK-.....-..NGRVEIIAN.DQg21gdAAKNQLTSNPENT
42 ----EDVGTVVGIDLGTTYSCVGVFK-.....-..NGRVEIIAN.DQg21gdAAKNQLTSNPENT
43 ----EDVGTVVGIDLGTTYSCVGVFK-.....-..NGRVEIIAN.DQg21gdAAKNQLTSNPENT
44 ----EDVGTVVGIDLGTTYSCVGVFK-.....-..NGRVEIIAN.DQg21gdAAKNQLTSNPENT
45 ----EDVGTVVGIDLGTTYSCVGVFK-.....-..NGRVEIIAN.DQg21gdAAKNQLTSNPENT
46 ----------LGIDLGTANTLVFVKGK.....GivVREPSVVAL.QTd23nvVALRPMKDGVIAD
47 ----------IGIDLGTANVLIHVKGK.....GivLNEPSVVAI.DRn23niVAIRPLKDGVIAD
48 ----------IGIDLGTTYSCVAVWQ-.....-..QDRVEIIAN.DQg25nq-----VAMNPYNT
49 ----------IGIDLGTTYSC--VGHF.....S..NNRVEIIAN.DQg28am--------NPHNT
50 ---EEKMGTIIGIDLGTTYSCVGVFK-.....-..NGRVEIIAN.DQg30ti--------NPENT
51 ---------EIGIDLGTANILVYSKNK.....GiiLNEPSVVAV.DTt23kiVAVRPMKDGVIAD
52 --KEESYGTVIGIDLGTTYSCVGVMQ-.....-..SGRVEILAN.DQg20gdAAKNQAPANPLNT
53 ---EESYGAVIGIDLGTTYSCVGVMQ-.....-..SGRVEILPN.DQg20gdAAKNQAPANPLNT
54 ----------MGIDLGTANTLVLVKDK.....GivINEPSVVAV.ERe27niEAIRPMKDGVIAD
55 ----EDVGTVVGIDLGTTYSCVGVFK-.....-..NGRVEIIAN.DQg21gdAAKNQLTSNPENT
56 ---------AVGIDLGTTYSCVGVWK-.....-..NDAVEIIAN.DQg20gdAAKNQVARNPENT
57 ---------AVGIDLGTTYSCVGVWK-.....-..NDAVEIIAN.DQg20gdAAKNQVARNPENT
58 ---------AVGIDLGTTYSCVGVWK-.....-..NDAVEIIAN.DQg20gdAAKNQVARNPENT
59 ----EDVGTVVGIDLGTTYSCVGVFK-.....-..NGRVEIIAN.DQg21gdAAKNQLTSNPENT
60 -------GVAIGIDLGTTYSCVGVFQ-.....-..HGKVEIIAN.DQg28alNPSNTVF------
61 ---------DMAVDLGTANTLVYVRGR.....GivLNEPSVVAI.NTn22niVAVRPLKDGVIAD
62 ---VENYGTVIGIDLGTTYSCVAVMK-.....-..NGKTEILAN.EQg20gdAAKNQVAANPQNT
63 ----------IGIDLGTTYSCVGIYQ-.....-..NGKVEILAN.SEg28ar--------NPENT
64 -----DIGTVIGIDLGTTYSCVGVYK-.....-..NGRVEIIAN.DQg21gdAAKNQLTTNPENT
65 -------APAIGIDLGTTYSCVGVFQ-.....-..HGKVEIIAN.DQg28amNPSNTVY------
66 -------APAIGIDLGTTYSCVGVFQ-.....-..HGKVEIIAN.DQg28amNPSNTVY------
67 ----------IGIDLGTANVLIHVKGK.....GivLNEPSVVAL.DKn23niVAIRPLKDGVIAD
68 -------GPVIGIDLGTTYSCVGVFK-.....-..NGRVEILNN.ELg28tlHPTQTVFD-----
69 ------KEFIVAIELGSSKMTGIAGQK.....Nl.DGSISVLSIvEE.....DSTSCIRKGVVYN
70 ----------IGIDLGTANVLIHVKGK.....GivLNEPSVVAL.DKn23niVAIRPLKDGVIAD
71 ---------AIGIDLGTTYSCVGIYQ-.....-..NGKVEILAN.SEg28ar--------NPENT
72 ---------IFALDVGTRKIAGLIAVE.....E..KGTIRIVDS.ELie...HKTRTMFDGQVHD
73 ------NTIYAVIDLGSWYIRGMVARK.....Me.DGRVSPISF.YEe....PANNCIRHGCVHN
74 ---------------------------.....-..---------.--.....-------------
75 ---FKSFLIDIGIDLGTCNTLVYIKDY.....GvvMSEPSVVAI.DIt24niKAVRPLRDGVIAD
76 ---------------------------.....-..---------.--.....-------------
77 ---------------------------.....-..---------.--.....-------------
78 ---------------------------.....-..---------.--.....-------------
79 ---------------------------.....-..---------.--.....-------------
80 ---------------------------.....-..---------.--.....-------------
81 ------GNEIIGIDLGTTNSCVAVMEGk11eg-a.RTTPSVVAF.NQkg8gtPAKRQAVTNPTNT
82 ---------------------------.....-..NGKVDIIAN.EAg20geAAKHQMANNPHNT
83 ---------VIGIDLGTTNSCVAVMDGk11egM..RTTPSIVAV.TDd16vt--------NPERT
84 ---------------------------.....-..---------.--.....-------------
85 ---------------------------.....-..---------.--.....-------------
86 ---------------------------.....-..---------.--.....-------------
87 ---------------------------.....-..---------.--.....-------------
88 ---------------------------.....-..---------.--.....-------------
89 ---------------------------.....-..---------.--.....-------------
90 ---------------------------.....-..---------.--.....-------------
91 ---------------------------.....-..---------.--.....-------------
92 ---------------------------.....-..---------.--.....-------------
93 ---------------------------.....-..---------.--.....-------------
94 ---------------------------.....-..---------.--.....-------------
95 ---------------------------.....-..---------.--.....-------------
96 ---------------------------.....-..---------.--.....-------------
97 ---------------------------.....-..---------.--.....-------------
98 ---------------------------.....-..---------.--.....-------------
99 -----QGAAVMSVDLGSEWMKVGVVSP.....G..VPME--IAL.NRe35ay--------GYLLD
60 70 80 90
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1 AIAFKESVNTLLKELEEQL..QKSLRSD.....FVISFSSVSFE.....REDTVI.....ERDF.
2 IESTVQSIQRAIDEAQQMA..GCRIHS-.....AFVGIAGNHIR.....SLNSHG.....IVAI.
3 IESTVQSIQRAVEEAQLMA..GCRIHS-.....AFVGVAGNHIR.....SLNSHG.....IVAI.
4 LESVVKCVQRAIDQAELMA..DCQISS-.....VYLALSGKHIS.....CQNEIG.....MVPI.
5 LESVVKCVQRAIDQAELMA..DCQISS-.....VYLALSGKHIS.....CQNEIG.....MVPI.
6 IDATVQAIRQAVNDAELMA..DTKITH-.....VTTGIAGNHIR.....SLNSQG.....VVKI.
7 IDATVQAIRQAVNDAELMA..DTKITH-.....VTTGIAGNHIR.....SLNSQG.....VVKI.
8 LDAVISCIRESIHQAEIMA..NCQITS-.....VYLSLSSKYIN.....CPNEIG.....IVPI.
9 LDAVVGSIQRAIEAAESMA..DCQIMS-.....VTLAITGEHIQ.....SLNESG.....FVPI.
10 IDETVHSIRKAFDQAERMV..GFPLRK-.....AIVGVNGNYIN.....IQDTNG.....VVAV.
11 LDAVESVVRLAVDAAERMA..GLTIDS-.....LIVNVSAGRLQ.....SDVYTA.....TIDL.
12 LERATQAIKQSLHAAERVS..GVRAWN-.....VFVSVGGNHTK.....AMTSHG.....LAAI.
13 AIAFKESVNTLLKELEEQL..QKSLRSD.....FVISFSSVSFE.....REDTVI.....ERDF.
14 LDALEGVIRLSVDAAERMA..GLTVDS-.....LIVNVSAGRLA.....SDIYTA.....SIDL.
15 LSEAKGSILRAMKEAEAMA..GLKVRE-.....VVYNVSGGTTKngtvkSQNVKD.....TISI.
16 IEAALDSISNSIEAAELIS..GCDITS-.....LSVSMSGSSVE.....GTNSRG.....VVAI.
17 IEAALDSISNSIEAAELIS..GCDITS-.....LSVSMSGSSVE.....GTNSRG.....VVAI.
18 MVAAERSIRLAVDAAEKMA..GLVVDS-.....VIVNFSSSCLK.....SSFING.....TVCL.
19 IDAAATAIKSAISQAEEKA..GISIKS-.....VNVGLPGNLLQ.....VEPTQG.....MIPV.
20 LAHASNAIKEVINSAKKMA..GLNADEDr17tkAIVSFSGAYTE.....SIRDVT.....GVAS.
21 IDKTVQAIQRAVRQAEEKA..GIQIKG-.....VSVGLPANLLE.....VENCQG.....MIAV.
22 LAHASNAIKEVINSAKKMA..GLNADEDr16tkAIVSFSGAYTE.....SIRDVT.....GVAS.
23 MESTEKAVREAVEQAERIA..GTNIES-.....VWVSFSAGGLI.....SDLSST.....EVAL.
24 IENTVVGIHHAVEAAEMMS..GIEVAH-.....CVVGLGGTHIE.....GRNLKG.....VVAVa
25 IELASKSIEEAVRSAEMMS..GVHYDR-.....VVVSISGAYTK.....SVDSIG.....VVNI.
26 IEKVAQALRKAVNAAEERA..GITIDR-.....INVSIPANSLE.....MEPCQG.....MVPI.
27 LKNAETSILTAIYALEKDC..GKNINK-.....IILSLSGAETK.....SYYINY.....TIKI.
28 IDQTVQAIQRAVRQAEEKA..GIQIKS-.....VNVGLPANLLE.....VESCQG.....MIAV.
29 VFDAKRLIGRKFADPEVQA..DMKHFPF.....KIT------DK.....GGKPVI.....QVEF.
30 FEVTEAMLKHFINKLNVKG..LFSKPR-.....-----------.....-----M.....LICC.
31 FEITERMLRYFILKIHKRR..YLARPR-.....-----------.....-----V.....VVCV.
32 YDITAKMIRYFIEKVHKRK..TWIRPR-.....-----------.....-----I.....MVCV.
33 YDITAKMIRYFIEKAHKRK..TWIRPR-.....-----------.....-----I.....MVCV.
34 YDITAKMIRYFIEKAHKRK..TWIRPR-.....-----------.....-----I.....MVCV.
35 VFEAKRLIGRKFADPEVQA..DMKHFPF.....------KITDK.....GGNPKI.....QVEF.
36 MDTTEKMIRYFISKILPRH..RLIKPR-.....-----------.....-----M.....VIGI.
37 VFDAKRLIGRTWNDPSVQQ..DIKFLP-.....-----FKVVEK.....KTKPYI.....QVDI.
38 FDIARQAIKDTIKKASIAS..GVDIKE-.....VFLKLPIIGTE.....VYDESN.....EIDF.
39 VFDAKRLIGRTWNDPSVQQ..DIKFLP-.....-----FKVVEK.....KTKPYI.....QVDI.
40 YETTATMMKYYINQAIKNK..GMFTRK-.....-----------.....---PYV.....MVCV.
41 VFDAKRLIGRTWNDPSVQQ..DIKFLP-.....-----FKVVEK.....KTKPYI.....QVDI.
42 VFDAKRLIGRTWNDPSVQQ..DIKFLP-.....-----FKVVEK.....KTKPYI.....QVDI.
43 VFDAKRLIGRTWNDPSVQQ..DIKFLP-.....-----FKVVEK.....KTKPYI.....QVDI.
44 VFDAKRLIGRTWNDPSVQQ..DIKFLP-.....-----FKVVEK.....KTKPYI.....QVDI.
45 VFDAKRLIGRTWNDPSVQQ..DIKFLP-.....-----FKVVEK.....KTKPYI.....QVDI.
46 YETTATMMKYYINQAIKNK..GMFARK-.....-----------.....---PYV.....MVCV.
47 FEITEAMLKYFINKLDVKS..FFSKPR-.....-----------.....-----I.....LICC.
48 VFDAKRLIGRKFEDAEVQS..DMKHWPF.....KVISRLASLHQ.....VEYARG.....----.
49 IFDAKRLIGRRFNDPEVQS..DMKHWPF.....KVIEKDGKP--.....----LI.....QVEF.
50 IFDAKRLIGRFYNEKTVQQ..DIKHWPF.....KIVD------K.....SNKPNV.....EVKV.
51 YDMTTDLLKHIMKKAAKSI..GMSFRK-.....-----------.....---PNV.....VVCT.
52 IFDVKRLIGRRFDDVDVQA..DMKHWP-.....-----FKVHHQ.....DGKPHV.....IVNI.
53 IFDVKRLIGRRFDEADVQS..DIKNFP-.....FKVNHHE----.....-GKPHV.....EVNI.
54 FDMTEKMIRYFIEKTHRRK..SFLRPR-.....-----------.....-----I.....IISV.
55 VFDAKRLIGRTWNDPSVQQ..DIKYLPF.....KV------VEK.....KAKPHI.....QVDV.
56 IFDAKRLIGRKFDDPSVQS..DMKHWPF.....KVIAGPGD---.....--KPLI.....EVTY.
57 IFDAKRLIGRKFDDPSVQS..DMKHWPF.....KVIAGPGD---.....--KPLI.....EVTY.
58 IFDAKRLIGRKFDDPSVQS..DMKHWPF.....KVIAGPGD---.....--KPLI.....EVTY.
59 VFDAKRLIGRTWNDPSVQQ..DIKFLP-.....-----FKVVEK.....KTKPYI.....QVDI.
60 --DAKRLIGRKFDEPVVQA..DMKHWPF.....KVISDGGK---.....---PKI.....RVEY.
61 FEITERMLRYFILKIHKRR..YLARPR-.....-----------.....-----V.....VVCV.
62 IFDIKRLIGLKYNDRSVQK..DIKHLPF.....NVVNKDGK---.....---PAV.....EVSV.
63 VFDAKRLIGRRFDESTVQS..DCKHWP-.....-----FGVKGK.....QGKPVI.....EVEV.
64 VFDAKRLIGREWSDQTVQH..DVKFFPF.....KV------VEK.....NSKPHV.....QVQT.
65 --DAKRLIGRKFDDKTVQN..DMKHWPF.....KVVEVDGRPK-.....-----I.....QAEY.
66 --DAKRLIGRKFDDKTVQN..DMKHWPF.....KVVEVDGRPK-.....-----I.....QAEY.
67 FEVTEAMLKHFINKLNVKG..LFSKPR-.....-----------.....-----M.....LICC.
68 ---VKRLIGRKFDDQEVVK..DRSLLPY.....EIVNNQGK---.....---PNI.....KVQI.
69 IEKTGQCLTSIMQKLKNNL..KQDITH-.....VYVGVGGQSIR.....SVKNVI.....VKDL.
70 FEVTEAMLKHFINKLNVKG..LFSKPR-.....-----------.....-----M.....LICC.
71 VFDAKRLIGRRFDEETVQS..DIKHWP-.....-----FTVKGK.....QGKPVV.....EVEV.
72 VLGVAETVKEVKERLESRN..EIELKE-.....VAVALAGRFLK.....TQVGEA.....ELDF.
73 IDEAAAIIRRIVNQLNENLedNTHITS-.....LYVGVGGQSIA.....SQEFIV.....RKAM.
74 -FDAKRLIGRKFDDPSVQS..DMKHWPF.....KVIAGPGD---.....--KPLI.....EVTY.
75 IENTEKMIKYFINQIFSRK..KLFFKP-.....-----------.....----RM.....VIGV.
76 -------------------..-------.....-----------.....------.....----.
77 -------------------..-------.....-----------.....---PNI.....EVTF.
78 -FDAKRLIGRKFTDSIVQS..DMKLWPF.....DVVDESGR---.....---PKI.....KVTH.
79 -------------------..-------.....-----------.....------.....----.
80 -------------------..-------.....-----------.....------.....----.
81 LSGTKRLIGRRFDDPQTQK..EMKMVP-.....YKIVRGSNGDA.....WVEANG.....QQYS.
82 IFAIKRLMGLRYSDKEVQN..ELKRLPY.....KVIDQDNR---.....---PFV.....EVQY.
83 FFAVKRLIGRRYDDPMVEK..DKKLVPY.....KIVKASNGD-A.....WVEADG.....----.
84 -------------------..-------.....-----------.....------.....----.
85 LSGTKRLIGRRFDDPQTQK..EMKMVP-.....YKIVKGSNGDA.....WVEANG.....QQYS.
86 -------------------..-------.....-----------.....------.....----.
87 -------------------..-------.....-----------.....------.....----.
88 -------------------..-------.....-----------.....------.....----.
89 -------------------..-------.....-----------.....------.....----.
90 -------------------..-------.....-----------.....------.....----.
91 -------------------..-------.....-----------.....------.....----.
92 -------------------..-------.....-----------.....------.....----.
93 -------------------..-------.....-----------.....------.....----.
94 -------------------..-------.....-----------.....------.....----.
95 -------------------..-------.....-----------.....------.....----.
96 -------------------..-------.....-----------.....------.....----.
97 -------------------..-------.....-----------.....------.....----.
98 -------------------..-------.....-----------.....------.....----.
99 -----------------LL..GKTIDN-.....PIVDLYRKRFP.....YYNIVGdp6ntVVFR.
100 110 120 130 140 150
| | | | | |
1 ..GEE.KRSITLDILSEMQSEALEK....LKENGKTPLHIFSKRYLLDDERIVFNPLDMKASK.I
2 ..RD-.-REVNPADIERVLDAAQAV....AIPADQRVLHTLAQDYVIDNQEGVREPLGMSGVR.L
3 ..RD-.-REVSLADLERVLDAAQAV....AIPADQRVLHTLPQDYVIDNQEGVREPLGMSGVR.L
4 ..SE-.-EEVTQEDVENVVHTAKSV....RVRDEHRVLHVIPQEYAIDYQEGIKNPVGLSGVR.M
5 ..SE-.-EEVTQEDVENVVHTAKSV....RVRDEHRVLHVIPQEYAIDYQEGIKNPVGLSGVR.M
6 ..KD-.-GEVTQADIDRAIETAKAI....NIPPDQKILDAVVQDYIIDTQLGVREPIGMSGVR.L
7 ..KD-.-GEVTQADIDRAIETAKAI....NIPPDQKILDAVVQDYIIDTQLGVREPIGMSGVR.L
8 ..SE-.-DEVTKEDIENVIHTAKSV....KILNEHHILHVIPQEYSIDQQSGIKNPIGLSGTR.M
9 ..AE-.-SEVTQEEIDSALHTASSI....KLPEGLSLLHVIPQEYAVDRQMNIKNPLGLQGVR.L
10 ..SSE.NKEIQVEDVRRVMAAAQVV....SVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVR.L
11 ..GG-.-QEVEANDLKKVLAAAGHQ....SLRTDRAILHSLPTGFSLDGERGIRDPLAMFGDV.L
12 ..RRQ.-QEISPPDVERAIENARAV....PLDPSLEILHTIPQEYVVDGQEGIKNPVGMHGVR.L
13 ..GEE.KRSITLDILSEMQSEALEK....LKENGKTPLHIFSKRYLLDDERIVFNPLDMKASK.I
14 ..GG-.-QEVEASDLRKVLVAASQQ....SMRQDRAILHSLPTGYSLDGERGIRDPLSMYGDL.L
15 ..STK.SSEIEESHIQRLHERCLMK....AKEEGYEIVYTAPRKYILDDHTEVKNPLGLVGSK.L
16 ..NSK.TREINEEDVERVIEAAKAI....VIPMDREILHVIPQEFIVDGIPHIKNPIDMMGIR.L
17 ..NSK.TREINEEDVERVIEAAKAI....VIPMDREILHVIPQEFIVDGIPHIKNPIDMMGIR.L
18 ..DG-.-HEVTPYDVRMALADVSRK....AFDAEHHIVHTVPAFYALDGNKGIVDPIGMIGKT.L
19 ..TSD.TKEITDQDVENVVKSALTK....SMTPDREVITFIPEEFIVDGFQGIRDPRGMMGVR.L
20 ..TKD.-NVVTIDEINRAINNACAKa...GLDNDKHILHALPYRFTLDKQE-VNDPLGMSGTR.L
21 ..NGD.SKEITDEDVRNVASAALVR....SIPPERQIVSILPQDFTVDGFEGIKDPRGMIGVR.L
22 ..TKD.-NVVTIDEINRAINSACAKa...GLDNDKHILHALPYRFTLDKQE-VNDPLGMSGTR.L
23 ..NG-.-QRIEEIHMETLLATGRDA....IDPDGHMVLHAQPALYTLDGLKGVKSPIGLYADR.L
24 dkGKG.HREVDQSDIDRVLEVACAV....SLPPDRKILHVIPKVYSVDDQHGITDPRNIIGVR.L
25 ..PN-.-HEIGIKEIHRAVSTAKHTa...NLPSGYEIIHVLPYNFKVNDLEHVDDPLGMSGNR.L
26 ..VSD.TKEITDNDVIQVVQNALMR....GIVPEREIIAVETKEFTVDGFTGISDPRGMFGVR.L
27 ..NG-.-QTVTQQDIKKLLQKALVE....FKFKNQEIIHYFPLEFTLDNNS-VENPIGMYGRA.L
28 ..SSE.SKEITDEDVCNVASAALVR....STPPERQIVAILPQDFTVDGFEGIKDPRGMLGVR.M
29 ..KGE.TKEFTPEEISSMVLTKMREtaeaYLGGTVNNAVVTVPAYFNDSQRQATKDAGLI---.-
30 ..PTN.ITSVEQKAIKEAAEK----....----------------------------------.-
31 ..PSG.ITGVERRAVIEASSQ----....----------------------------------.-
32 ..PYG.LTSVERNAVKESTLS----....----------------------------------.-
33 ..PYG.LTSVERNAVKESALS----....----------------------------------.-
34 ..PYG.LTSVERNAVKESALS----....----------------------------------.-
35 ..RGE.GKHFTPEGISSMFRRKKREiaesYLGGTVNNAVVTVPAYFNDSQRQVTKDAGLI---.-
36 ..PSC.ITDVECRAVHESASK----....----------------------------------.-
37 ..GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATKDAGTI---.-
38 ..YED.-TEINGSHIEKVLEGIREK....NDVQETEVINVFPIRFIVDKENEVSDPKELIARHsL
39 ..GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATKDAGTI---.-
40 ..PSG.ITAVEERAVIDATRQ----....----------------------------------.-
41 ..GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATKDAGTI---.-
42 ..GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATKDAGTI---.-
43 ..GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATKDAGTI---.-
44 ..GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATKDAGTI---.-
45 ..GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATKDAGTI---.-
46 ..PSG.ITAVEERAVIDATRQ----....----------------------------------.-
47 ..PTN.ITSVEQKAIREAAER----....----------------------------------.-
48 ..---.-EEFSPEEISSMVLIKMKEtaeaYLGGTVSKAVVTVPAYFNDSQRQATKDAGTI---.-
49 ..KGE.TKTFTPEEISSMVLLKMREsaeaFLGGKVTDAVVTVPAYFNDSQRQATKDAGLI---.-
50 ..GSE.TKQFTPEEVSAMVLTKMKQiaesYLGHEVKNAVVTVPAYFNDAQKQATKDAGSI---.-
51 ..PSG.STAVERRAISDAVKN----....----------------------------------.-
52 ..AGE.KKTFTPEEISAMVLRKMKEiaesYLGRTVTHAVVAVPAYFNDAQRQATKDAGTI---.-
53 ..AGE.KKTFTPEEISAMVLRKMKEiaesYLGRTVTHAVVTVPAYFNDAQRQATKDAGTI---.-
54 ..PYG.LTQVERKAVRESALS----....----------------------------------.-
55 ..GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATKDAGTI---.-
56 ..QGE.KKTFHPEEVSAMVLGKMKEiaeaYLGKEVKEAVITVPAYFNDSQRQATKDAGTI---.-
57 ..QGE.KKTFHPEEVSAMVLGKMKEiaeaYLGKEVKEAVITVPAYFNDSQRQATKDAGTI---.-
58 ..QGE.KKTFHPEEVSAMVLGKMKEiaeaYLGKEVKEAVITVPAYFNDSQRQATKDAGTI---.-
59 ..GGGqTKTFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATKDAGTI---.-
60 ..KGE.DKAFYPEEISSMVLVKMKEiaeaYLGQKVSNAVITVPAYFNDSQRQATKDAGVI---.-
61 ..PSG.ITGVERRAVIEASSQ----....----------------------------------.-
62 ..KGE.KKVFTPEEISGMILGKMKQiaedYLGTKVTHAVVTVPAYFNDAQRQATKDAGTI---.-
63 ..KGE.KRQFNPEEISAMVLQKMKEtaetYLGHTVKDAVITVPAYFNDSQRQATKDAATI---.-
64 ..SQG.DKVFAPEEISAMVLTKMKEtaeaYLGKKVTHAVVTVPAYFNDAQRQATKDAGTI---.-
65 ..RGE.NKLFAPEEISSMVLTKMKEtaeaYLGQKITDSVITVPAYFNDSQRQATKDAGAI---.-
66 ..RGE.NKLFAPEEISSMVLTKMKEtaeaYLGQKITDSVITVPAYFNDSQRQATKDAGAI---.-
67 ..PTN.ITSVEQKAIKEAAEK----....----------------------------------.-
68 ..KDK.DTTFAPEQISAMVLEKMKEiaqsFLGKPVKNAVVTVPAYFNDAQRQATKDAGTI---.-
69 ..PSA.-TQVTQEMVNELMDANRNM....SYP-DLEILDAATQEYKLDNQF-QLDPVGIQCTH.L
70 ..PTN.ITSVEQKAIKEAAEK----....----------------------------------.-
71 ..KGE.KREFNAEEISAMVLQKMKEtaeaVLGHSVRDAVITVPAYFNDSQRQATKDAATI---.-
72 ..SK-.VGHITREDVMKLEIEAVTKaqe.SVEEDFFCVGYSVVEYRLDGMW-MKKLEGHRGGK.A
73 ..VPE.GEVIRTEHIESLWAEMRGA....SFP-DKEVLDVTDPLFYVDGKQ-EIQAKGVFCHE.L
74 ..QGE.KKTFHPEEVSAMVLGKMKEiaeaYLGKEVKEAVITVPAYFNDSQRQATKDAGTI---.-
75 ..PTC.ITEVERRAVKESAMN----....----------------------------------.-
76 ..---.--------------ETAES....YLGGTVNNAVVTVPAYFNGSQRQATKDAGLI---.-
77 ..QGE.RKTFHAEEISSMVLTKMKEiaeaFIGKTVKDVVITVPAYFNDSQRQATKDAGTI---.-
78 ..QCK.DKTFFAEEISSMVLGKMKEtaeaYLGKTVNDAVITVPAYFNDSQRQATKDAGVI---.-
79 ..---.-------------------....----------------------------------.-
80 ..---.---FAPEQISAMVLEKMKEiaqsFLGKPVKNAVVTVPAYFNDAQRQATKDAGTI---.-
81 ..PTQ.IGAFILTKMKETAEAYLGK....----SINKAVITVPAYFNDAQRQAIKDAGAI---.-
82 ..KGK.TEHYSPEEISAMILSKMKTiaeeYLGRPVKNAVVTCPAYFNDAQRKATADAGTI---.-
83 ..---.-QTYSPSQVSAFILQKMKEtaeaHLGQKVDQAVITVPAYFNDAQRQATKDAGKI---.-
84 ..---.-------------------....-------------PAYFNDAQRQATKDAGKI---.-
85 ..PSQ.IGAFILTKMKETAEAYLGK....----SINKAVITVPAYFNDAQRQATKDAGRI---.-
86 ..---.-------------------....---------------YFNDAQRQATKDAGAI---.-
87 ..---.-----------------ES....YLGSKVKNVVITVPAYFNDSQRQATKDAGKI---.-
88 ..---.-------------------....----------------------------------.-
89 ..---.-------------------....----------------------------------.-
90 ..---.-------------------....-----------------------------AI---.-
91 ..---.-------------------....----------------------------------.-
92 ..---.-------------------....----------------------------------.-
93 ..---.-------------------....----------------------------------.-
94 ..---.-------------------....----------------------------------.-
95 ..---.-------------------....----------------------------------.-
96 ..---.-------------------....----------------------------------.-
97 ..---.-------------------....----------------------------------.-
98 ..---.-------------------....----------------------------------.-
99 ..KSD.TDEFSVEELVAQLLVKAKQfaqeSVQQPITECVLTVPGYF-----------------.-
160 170 180 190 200 210
| | | | | |
1 AIEYTSIVVPLKVYEMFYNFLQ.DTVKSPFQLKSSLVSTAEGVLTTP.....EKDRGVVVVNLGY
2 EAKVHVVTCAVNASQNIEKCVR.RCGLEVDDIILEQLASAYSVLTED.....EKELGVCLVDIGG
3 EAKVHVVTCAVNAAQNIEKCVR.RCGLEIDDIILEQLASAYSVLTDD.....EKELGVCLVDIGG
4 QAKVHLITCHNDMAKNIVKAVE.RCGLKVDQLIFAGLASSYSVLTED.....ERELGVCVVDIGG
5 QAKVHLITCHNDMAKNIVKAVE.RCGLKVDQLIFAGLASSYSVLTED.....ERELGVCVVDIGG
6 DTRVHIITGASTAVQNVQKCIE.RCGLKSDQIMLQPLASGQAVLTED.....EKDLGVCVIDIGG
7 DTRVHIITGASTAVQNVQKCIE.RCGLKSDQIMLQPLASGQAVLTED.....EKDLGVCVIDIGG
8 QVRVHLITCHQNMAKNIIKAVE.KCDIKVDQVIFSGLASSKAVLTED.....ECKLGVCMIDIGG
9 KAQVHLIACHQDWQNNLKKAVE.RCGLQVDKVVFSGFAATHSVLTED.....EKDLGVCLIDFGA
10 EVEGTLITGSKTILHNLLRCVE.RAGIEITDICLQPLAAGSAALSKD.....EKNLGVALIDIGG
11 GVDMHVLTAERPALKNLELCVN.RAHLSVEGMVATPYASGLAALVDD.....EVELGCAAIDMGG
12 EVDVHIVAGSAGPLLNLRRCVQ.EAGLQIEGFVLHSLASGLATLDHS.....EQNQTTVVVDMGG
13 AIEYTSIVVPLKVYEMFYNFLQ.DTVKSPFQLKSSLVSTAEGVLTTP.....EKDRGVVVVNLGY
14 GVDMHVVTVERTALKNLELCVN.RAHLSVEGMVATPYASGLAALVDD.....EVELGCAAIDMGG
15 SVEMHVVKVSTTILRNLEKAIR.EVGLNPVGRTVNAIASADSVLTHD.....EKEDGVLLLDMGA
16 EGGVHIITGSSSSSQNLVRCVN.RAGFAVDEVVLGSLASSYATLSKE.....EREMGVLFIDMGK
17 EGEVHIITGSSSSSQNLVRCVN.RAGFAVDEVVLGSLASSYATLSKE.....EREMGVLFIDMGK
18 GVNVHVVTAETAPLRNLETCIN.RAHLSVEAMVATPFASGLSVLIND.....EARLGAACIDLGG
19 EMRGLLYTGPRTILHNLRKTVE.RAGVQVENVIISPLAMVQSVLNEG.....EREFGATVIDMGA
20 EVFIHIVYTEKNNIENLEKIMI.QSGVEIENIVINSYAASIATLSND.....ERELGVACVDMGG
21 EMYGLLFTGPKTIVHNIRKCVE.NAGLVVNELVITPLALTETILSDG.....EKDFGTIVIDMGG
22 EVFIHIVYTEKNNIENLEKIMI.QSGVEIENIVINSYAASIATLSND.....ERELGVACVDMGG
23 GVDIHVIAAEPSPVRYLELAVR.SAHLEVQAIVAAPIAAGMSCLFAE.....ERELGVALVELGA
24 EGEVHMITGSATCMRSVIDCVK.RANLHIDFLMHNGLAAVRSVLNDD.....ERNVGCVLINIGG
25 EVSTHIVISQESHIKNLKKAVE.LADLRVDNIVLSGYASAIACLDDS.....EKELGAVLIDMGG
26 EIRGVVYTGPKTLVHNVRKVVE.RAGLLVDNIVIAPLAMRQYVLTEG.....EREFGTIMVDLGA
27 SCELHIISARSNLLSNIVQCFA.KCHVEVTNITLAIYASAISCLTND.....EKNLGVLIIDIGD
28 EMFGVVYTGPKTIIHNIRKCVE.KAGLGINELVITPLALTETILTDG.....EKDFGTIVIDMGG
29 ----------------------.-AGLNVLRIINEPTAAAIAYGLDKka...DGERNVLIFDLGG
30 ----------------------.-SGGKHVYLEEEPKVAAIGAGMEI.....FQPSGNMVVDIGG
31 ----------------------.-AGARQVHIIEEPMAAAIGSGLPV.....HEATGNMVVDIGG
32 ----------------------.-AGAREVFLIEEPMAAAIGAGLPV.....KEPQGSLIVDIGG
33 ----------------------.-AGAREVFLIEEPMAAAIGAGLPV.....KEPQGSLIVDIGG
34 ----------------------.-AGAREVFLIEEPMAAAIGAGLPV.....KEPQGSLIVDIGG
35 ----------------------.-AGLNVLRIINEPTAAAIAYGLDKka...EGERNVLILDLGG
36 ----------------------.-AGAGEVEVLEESLAAAIGANIPI.....EEPAGNMVCDIGG
37 ----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGEKNILVFDLGG
38 KVEAGVIAIQKSILINMIKCVE.ACGVDVLDVYSDAYNYG-SILTAT.....EKELGACVIDIGE
39 ----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGEKNILVFDLGG
40 ----------------------.-AGARDAYPIEEPFAAAIGANLPV.....WEPTGSMVVDIGG
41 ----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGEKNILVFDLGG
42 ----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGEKNILVFDLGG
43 ----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGEKNILVFDLGG
44 ----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGEKNILVFDLGG
45 ----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGEKNILVFDLGG
46 ----------------------.-AGARDAYPIEEPFAAAIGANLPV.....WEPTGSMVVDIGG
47 ----------------------.-SGGKTVFLEEEPKVAAVGAGMEI.....FQPSGNMVVDIGG
48 ----------------------.-AGLEVLRIINEPTAAAIAYGLDKks...EGEKNVLIFDLGG
49 ----------------------.-AGLNVLRIINEPTAAAIAYGLDRsn...QHETNVLIFDLGG
50 ----------------------.-AGLNVVRIINEPTAAAIAYGLDKk....DGERNILVFDLGG
51 ----------------------.-CGAKNVHLIEEPVAAAIGADLPV.....DEPVANVVVDIGG
52 ----------------------.-AGLNVLRIVNEPTAAAIAYGLDKk....EGERLIIVYDLGG
53 ----------------------.-AGLNVLRIVNEPTAAAIAYGLDKk....EGERLIIVYDLGG
54 ----------------------.-AGAREVFLIEEPMAAAIGASLPI.....QEPKGNLVVDIGG
55 ----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGEKNILVFDLGG
56 ----------------------.-AGLSVLRIINEPTAAAIAYGLDKkg...CGEMNVLIFDMGG
57 ----------------------.-AGLSVLRIINEPTAAAIAYGLDKkg...CGEMNVLIFDMGG
58 ----------------------.-AGLSVLRIINEPTAAAIAYGLDKkg...CGEMNVLIFDMGG
59 ----------------------.-AGLNVMRIINEPTAAAIAYGLDKr....EGEKNILVFDLGG
60 ----------------------.-AGLNVLRIINEPTAAAIAYGLDKgk...SGERNVLIFDLGG
61 ----------------------.-AGARQVHIIEEPMAAAIGSGLPV.....HEATGNMVVDIGG
62 ----------------------.-AGLNVLRIVNEPTAAAIAYGLDKs....DKEHQIIVYDLGG
63 ----------------------.-AGLNAIRIINEPTAAALAYGLDKgi...QDEKNVLIFDLGG
64 ----------------------.-SGLNVMRIINEPTAAAIAYGLDKk....EGEKNVLVFDLGG
65 ----------------------.-AGLNVLRIINEPTAAALAYGLDKgh...KGEKNVLIFDLGG
66 ----------------------.-AGLNVLRIINEPTAAALAYGLDKgh...KGEKNVLIFDLGG
67 ----------------------.-SGGKHVYLEEEPKVAAIGAGMEI.....FQPSGNMVVDIGG
68 ----------------------.-AGLNIVRIINEPTAAALAYGLDK.....KEETSILVYDLGG
69 EGNFLNILWRKNFYRNLNTCFD.NAGIAIAEMYLAPLALADSTLTDA.....EKRSGCVLIDLGA
70 ----------------------.-SGGKHVYLEEEPKVAAIGAGMEI.....FQPSGNMVVDIGG
71 ----------------------.-AGLNAIRIINEPTAAALAYGLDKgi...TDEKNILIFDLGG
72 YVKVVSAFLPVHVVDSLMRVLE.TVGLTPVHVTLEPIAAMDLTVPED.....LRYLNISLVDVGA
73 EARFQLITARRSVKQNIRIAIEeRLGLRLAGILVTPLCEAQVLLSDD.....ELTLGCCYVNIGA
74 ----------------------.-AGLSVLRIINEPTAAAIAYGLDKkg...CGEMNVLIFDMGG
75 ----------------------.-AGAREVKVIEESLAAAIGSDIPI.....FEPTGHMVCDIGG
76 ----------------------.-AGLNVLRIINEPTAAAIAYGLDKka...EGERNVLIFDLGG
77 ----------------------.-AGLNVMRIINEPTAAAIAYGLDKks...GGEKNVLIFDLGG
78 ----------------------.-ARINVLRIINEPIAAAIAYGLDKkgnt.QGERNVLIFDLGG
79 ----------------------.-------------LASAYSVLTED.....EKELGVCLVDIGG
80 ----------------------.-AGLNIVRIINEPTAAALAYGLDK.....KEETSILVYDLGG
81 ----------------------.-AGLDVQRIINEPTAAALSYGMNS.....KEGL-VAVFDLGG
82 ----------------------.-AGLNVVRILNEPTAASLAYGLNK.....KGSKKILVFDLGG
83 ----------------------.-AGLEVLRIINEPTAAALAYGLDK.....TKTGTIAVYDLGG
84 ----------------------.-AGLNVLRILNEPTAAAMAYGLNKv....TGEKNILVFDLGG
85 ----------------------.-AGLDVQRIINEPTAAALSYGMNS.....KEGL-VAVFDLGG
86 ----------------------.-AGLNVLRIINEPTAAALAYGLDKgq...KGEKHVLIFDLGG
87 ----------------------.-AGMEVLRVINEPTAAALAYGLDR.....TDDKTIAVYDLGG
88 ----------------------.---------------AAIAYGLDKka...EGERNVLIFDLGG
89 ----------------------.IAGLEVERIINEPTAAALAYGLEK.....KKNEKIVVFDLGG
90 ----------------------.-AGLNVLRIINEPTAAALAYGLDKgq...KGEKHVLIFDLGG
91 ----------------------.IAGLEVLRIVNEPTAAALAYGSDK.....KKDETIAVYDFGG
92 ----------------------.-AGLEVLRIVNEPTAAAIAYGRDRsse..GAMKTVLIFDLGG
93 ----------------------.----------------AIAYGLDKkg...KGERNILIFDLGG
94 ----------------------.IAGLEVLRIVNEPTAAALAYGLDK.....KKDETIAVFDFGG
95 ----------------------.-AGLEVERIINEPTAAALAYGFDKk....NVNSKIAVYDLGG
96 ----------------------.------------------------.....-------------
97 ----------------------.------------------------.....-------------
98 ----------------------.------------------------.....-------------
99 ---------GQAEREALLSAAQ.LANLKVLQLINDYAAVALNYGVFHrgeinETAQYFLFYDMGA
220 230 240 250 260 270
| | | | | |
1 NFTGLIAYKNGVPIK.....ISYVPVGMKHVIKDVS.....AVLDTSFEESERLIITHGNAVYND
2 GTTDIAIFTEGAIRH.....TAVIPIAGDQVTNDIA.....MALRTPTQYAEEIKIRYACALAKL
3 GTTDIAIFTEGAIRH.....TAVIPIAGDQVTNDIA.....MALRTPTQYAEEIKIRYTCALAKL
4 GTMDIAVYTGGALRH.....TKVIPYAGNVVTSDIA.....YAFGTPPSDAEAIKVRHGCALGSI
5 GTMDIAVYTGGALRH.....TKVIPYAGNVVTSDIA.....YAFGTPPSDAEAIKVRHGCALGSI
6 GTTDIAVYMNGAIRH.....TSVIPAGGNLITKDLS.....KSLRTPLDAAEYIKIHYGVASCDT
7 GTTDIAVYMNGAIRH.....TSVIPAGGNLITKDLS.....KSLRTPLDAAEYIKIHYGVASCDT
8 GTIDLITYIDGSIQD.....SQVIPYAGNIVTKDIS.....YAFSTSYSDSEKIKIKYGSAIKLS
9 GTMNVMVYTNGALRF.....SKVIPYAGNIVTNDIA.....HACTISRAEAERIKVNYASAFYPA
10 GSTTIAVFQNGHLTS.....TRVIPLGGENITKDIS.....IGLRTSTEEAERVKKQLGHAYYDE
11 GTTTISVFAEGKLVH.....ADAVGLGGHHVTTDLA.....RGLSTRIEDAERLKVVHGSALPNS
12 GTTDIGVFKRGNLAH.....SASIPIGGDHVTADLA.....QILKIPMEEAEKVKRHYGAAIPEL
13 NFTGLIAYKNGVPIK.....ISYVPVGMKHVIKDVS.....AVLDTSFEESERLIITHGNAVYND
14 GTTTISVFAEGRLIH.....TDAIGLGGHHVTTDLA.....RGLSTRIEDAERLKVVHGSALLNG
15 GLTDYSLYTEGRPYI.....TGVVPFGGINITKDLS.....YMLKIDTETAESVKVNHGVAFESL
16 GTTDIILYIDGSPYY.....TGVIPIGVNRVTLDIA.....QVWKVPEDVAENIKITAGIAHPSI
17 GTTDIILYIDGSPYY.....TGVIPIGVNRVTLDIA.....QVWKVPEDVAENIKITAGIAHPSI
18 GTTTLSVFSEGKFVH.....TDVLPVGGHHVTLDVA.....RGFSMSIEEAERLKIVYGSTFSMS
19 GQTTVATIRNQELQF.....THILQEGGDYVTKDIS.....KVLKTSRKLAEGLKLNYGEAYPPL
20 ETCNLTIYSGNSIRY.....NKYLPVGSHHLTTDLS.....HMLNTPFPYAEEVKIKYGDLSFES
21 GQTTTAVMHDKQLKF.....TSLDQEGGEFVTKDIS.....IVLNTSFNNAEALKINYGDAYPER
22 ETCNLTIYSGNSIRY.....NKYLPVGSHHLTTDLS.....HMLNTPFPYAEEVKIKYGDLSFEG
23 GVTNVSLFAGGLLVG.....LTSIPMGASDITDDIA.....AAFGTRRSDAERLKCFYGSAQSSP
24 GTTDVIAMYKGSPVL.....ITSIPVGGSQVTSDLA.....KVKNLPLETAERIKIKDGCCWIPL
25 AICDMVVHTGNSIRY.....NDCLQIGSINITQDLS.....MALHTPLKEAEKIKLNYAALS--Q
26 GQTTVSIVKDQSLKF.....THTSPEGGDYVTKDIS.....TVLNTSVSAAEDLKVNYGEASTER
27 QTTSCGIFFADKLIY.....TWHLNIGSFHISLDIA.....KVFGIDLVTAEKLKILYGNAIIPL
28 GQTTTSVIHDKQLKF.....THVNQEGGEFITKDIS.....IVLNTSFNNAEALKINYGDAYPER
29 GTFDVSLLTIEEGIFevkstAGDTHLGGEDFDNRLVn20raRALRRSPTACERAKRTLSSAA---
30 GTTDIAVISMGDIVT.....SSSIKMAGDKFDMEILny6reYKLLIGERTAEDIKIKVATVFPDA
31 GTTEVAVISLGGIVT.....AQSIRVAGDELDNAIIqh6keYSLLLGERTAEQIKITIGSAYDLD
32 GTTEIGVISLGGLVI.....SKSIRVAGDKLDQSIVey6kkFNLLIGERTGEEIKIEIGCAIKLD
33 GTTEIGVISLGGLVI.....SKSIRVAGDKLDQSIVey6kkFNLLIGERTGEEIKIEIGCAIKLD
34 GTTEIGVISLGGLVI.....SKSIRVAGDKLDQSIVey6kkFNLLIGERTGEEIKIEIGCAIKLD
35 GTFDVSLLTIEEGIFevkstAGDTHFGGEDFDNRLVn19naRALRRLRTACERAKRTLSSAA---
36 GTTEVSVISLLGMVV.....TNAIRVGGDEFDQAIIkh6svHNLIIGEQTAERLKIEIGNASPEK
37 GTFDVSLLTIDNGVFevvatNGDTHLGGEDFDQRVMe19dnRAVQKLRREVEKAKRALSSQH---
38 DVTQVAFYERGELVD.....ADSIEMAGRDITRRYCtri..KALLMKL-----LKKLNTNMVMHS
39 GTFDVSLLTIDNGVFevvatNGDTHLGGEDFDQRVMe19dnRAVQKLRREVEKAKRALSSQH---
40 GTTEVAIISLGGIVT.....SQSIRVAGDEMDDAIIny6ktYNLMIGDRTAEAIKMEIGSAEAPE
41 GTFDVSLLTIDNGVFevvatNGDTHLGGEDFDQRVMe19dnRAVQKLRREVEKAKRALSSQH---
42 GTFDVSLLTIDNGVFevvatNGDTHLGGEDFDQRVMe19dnRAVQKLRREVEKAKRALSSQH---
43 GTFDVSLLTIDNGVFevvatNGDTHLGGEDFDQRVMe19dnRAVQKLRREVEKAKRALSSQH---
44 GTFDVSLLTIDNGVFevvatNGDTHLGGEDFDQRVMe19dnRAVQKLRREVEKAKRALSSQH---
45 GTFDVSLLTIDNGVFevvatNGDTHLGGEDFDQRVMe19dnRAVQKLRREVEKAKRALSSQH---
46 GTTEVAIISLGGIVT.....SQSIRVAGDEMDDAIIny6ktYNLMIGDRTAEAIKMEIGSAEAPE
47 GTTDIAVLSMGDIVT.....SSSIKMAGDKFDMEILny6rkYKLLIGERTSEDIKIKVGTVFPGA
48 GTFDVSLLTIEEGIFevkatAGDTHLGGEDFDNRLVn19naRALRRLRTACERAKRTLSSAA---
49 GTFDVSLLTIEEGIFevkatAGDTHLGGEDFDSRLVn19naRAVRRLRTACERAKRTLSSSA---
50 GTFDVSLLTIDSGVFevlatNGDTHLGGEDFDQRVMe19dnRAVQKLRREVEKAKRALSTQH---
51 GTTEVAIISFGGVVS.....CHSIRIGGDQLDEDIVsf6kkYNLLIGERTAEQVKMEIGHALIEH
52 GTFDVSLLSIEDGVFeviatAGDTHLGGEDFDHQVMs19dpKALGKLKREVEKAKRILSSQM---
53 GTFDVSLLSIEDGVFeviatAGDTHLGGEDFDHQVMa19dpKALGKLKREVEKAKRTLSSQM---
54 GTTEIGVISLGGLVI.....SKSIRTAGDKLDMSIVny6ekYNLIIGERTGEEIKITIGSAIQLP
55 GTFDVSLLTIDNGVFevvatNGDTHLGGEDFDQRVMe19dnRAVQKLRREVEKAKRALSSQH---
56 GTFDVSLLTIEDGIFevkatAGDTHLGGEDFDNRLVd20nsRALRRLRTQCERTKRTLSSST---
57 GTFDVSLLTIEDGIFevkatAGDTHLGGEDFDNRLVd20nsRALRRLRTQCERTKRTLSSST---
58 GTFDVSLLTIEDGIFevkatAGDTHLGGEDFDNRLVd20nsRALRRLRTQCERTKRTLSSST---
59 GTFDVSLLTIDNGVFevvatNGDTHLGGEDFDQRVMe19dnRAVQKLRREVEKAKALSSQH----
60 GTFDVSILTIEDGIFevkstAGDTHLGGEDFDNRMVn19nkRALRRLRTAFERAKRTLSSSS---
61 GTTEVAVISLGGIVT.....AS-PSVAGDELDNAIIqh6keYSLLLGERTAEQIKITIGSAYDLD
62 GTFDVSLLSIENGVFevqatSGDTHLGGEDFDYKIVr19nnKALAKLKREAEKAKRALSSQM---
63 GTFDVSILSIAEGSIfe6stAGDTHLGGEDFDQRMLq19npRAIRRLRTACERAKRTLSSSS---
64 GTFDVSLLTIDNGVFevvatNGDTHLGGEDFDQRVMe19dnRAVQKLRREVEKAKRALSSSH---
65 GTFDVSILTIDEGSMfe6atAGDTHLGGEDFDNRMVt19npRAIRRLQTACERAKRTLSSSS---
66 GTFDVSILTIDEGSMfe6atAGDTHLGGEDFDNRMVt19npRAIRRLQTACERAKRTLSSSS---
67 GTTDIAVISMGDIVT.....SSSIKMAGDKFDMEILny6reYKLLIGERTAEDIKIKVATVFPDA
68 GTFDVSILVIDNGVFevyatAGNTHLGGEDFDQRVMd19dkRAIQKLRKEVEIAKRNLSVVH---
69 DTTTVSVYYKNILRH.....LAVIPLGGSNITKDI-.....ASLQMEDSDAEKMKIKYASAF--T
70 GTTDIAVISMGDIVT.....SSSIKMAGDKFDMEILny6reYKLLIGERTAEDIKIKVATVFPDA
71 GTFDVSILSIAEGSIfe6stAGDTHLGGEDFDSRVLq19npRAIRRLRTACERAKRTLSSST---
72 GTSDIAISKEGTVVA.....YGMIPMAGDEITEAIG.....KKFLLDFQTAEHVKRTVFSEERVK
73 GCTSVSIYKNRLLAM.....LRVLPMGGYNVTRDL-.....TSLRLTEQEAENMKLNHVSMINDN
74 GTFDVSLLTIEDGIFevkatAGDTHLGGEDFDNRLVd20nsRALRRLRTQCERTKRTLSSST---
75 GTTEISVISLGGMVV.....SRAIRTGGDEFDESIIky6nsHNIIIGQQTAEKLKIKIGNVYPDI
76 GTFDVSLLTIEEGIFevkstAGDTHLGGEDFDNRLVn19naRALRRLRTACERAKRTLSSAA---
77 GTFDVSILTIEDGIFevkatAGDTHLGGEDFDNLLVe20nkRALRRLRTHCERAKRVLSSST---
78 GTFDVSILSIEDGIFevkstNGDTHLGGEDFDNRMVn19nkRSLRRLRTACERAKRTLSSSA---
79 GTTDIAIFTEGAIRH.....TAVIPIAGDQVTNDIA.....MALRTPTQYAEEIKIRYACALAKL
80 GTFDVSILVIDNGVFevyatAGNTHLGGEDFDQRVMd19dkRAIQKLRKEVEIAKRNLSVVH---
81 GTFDVSILEISNGVFevkatNGDTFLGGEDFDNALLe19dkLALQRLREAAEKAKIELSSTSQTD
82 GTFDVSCLAVDDGLFevlatGGDTHLGGEDFDDRTIe19naKAMAKLKREAEKAKHTLSTLP---
83 GTFDISILEIGDGVFevkstNGDTFLGGEDFDMRLVg19dkLALQRLKEAAEKAKIELSSTTQTE
84 GTFDVSLLNIEENVFdvvstSGDTHLGGSDFDQKVTe19dkRAVTRLRREAERAKRTLSVQQ---
85 GTFDVSILEISNGVFevkatNGDTFLGGEDFDNALLe19dkLALQRLREAAEKAKIELSSTSQTD
86 GTFDVSVLAIDEGSIfe6atAGDTHLGGEDFDNRLVa19naRAIRRLRTACERAKRTLSSSS---
87 GTFDISVLEIQKGVFevkstNGDTFLGGEDFDNELLr19dpMALQRVKEAAEKAKIELSSSLQTD
88 GTFDVSLLTIEEAIFevkstAGDTHLGGEDFDNRLVn19naRALRRLRTACERAKRTLSSAA---
89 GTFDVSVLEVTEELVevlstNGDTHLGGDDFDEELIn19dpMALQRLREAAEKGKKELSSSQQTD
90 GTFDVSVLAIDEGSIfe6atAGDTHLGGEDFDNRLVa19naRAIRRLRTACERAKRTLSSSS---
91 GTFDISILEVGEGVVevkstNGDTHLGGDNIDQKVMd19dkMALQRLKEAAEKAKMELSSVMETE
92 GTFDVTLLNIDGGLFevratAGDTHLGGEDFDSRLVd19naRAMRRLRTACERVKRTLSSSA---
93 GTFDVSLLTIDDGIFevkatAGDTHLGGEDFDNRMVn19npRALRRLRTACERAKALSSQT----
94 GTFDISILEVGEGVVevkstNGDTHLGGDDIDEALVg18qdKMALQRLKEPSRAKVELSSAMETE
95 GTFDISILELADGVFevkstNGDTHLGGDDFDMAIMe19dkNTVQRLKEAAEKAKIELSGTMSTQ
96 ---------------.....------GGEDFDNRMVn19npRALRRLRTACERAKRTLSSTA---
97 -------LNINGGVFavkatAGDTHLGGEDFDNALLe19daRALRRLRSACERAKRTLSSVT---
98 ---------------.....----------------.....------------------------
99 YKTSAAVVSYQLVKDk15gvGYDRTLGGLEIQLRLRd21spRALAKLFKEAGRLKNVLSANT---
280 290 300 310
| | | |
1 LK.....EEEIQYRGLD...GNT....I....KTTTAKKL.SVIIHARLREIMSK.SKKFFRE.V
2 AGa....GETIKVPSVG...DRP....P....RELSRQAL.AEVVEPRYDELFTL.VQAELRR.S
3 AGa....GETIKVPSVG...DRP....P....RELSRQAL.AEVVEPRYDELFTL.IQAELRR.S
4 VGk....DESVEVPSVG...GRP....P....RSLQRQTL.AEVIEPRYTELLNL.VNEEILQ.L
5 VGk....DESVEVPSVG...GRP....P....RSLQRQTL.AEVIEPRYTELLNL.VNEEILQ.L
6 EGl....GEMIEVPGVG...DRT....S....RQVSSKVL.AAIISARIQEIFGV.VLGELQK.S
7 EGl....GEMIEVPGVG...DRT....S....RQVSSKVL.AAIISARIQEIFGV.VLGELQK.S
8 PGt....SKNIDLSSKY...GNF....Q....KNLQQDTV.IEVIDSRYNELLHL.INNRILY.V
9 RLhg...DKKIEVASIG...GRA....P....RSLTKSDL.SLITSARYTELLGV.VKDELDK.L
10 ASe....DEIFEVTVIG...TNQ....K....QTFTQQEA.ANIIEARVEEILEI.VSEELRS.M
11 ADe....RDIISVPPIGeddRDQ....P....THVPRALV.SRIVRARIEETLEL.IRDRIQR.S
12 AD.....QELTLEITTA...SGA....T....HAISAYEL.SRVIRPRVSEIYGL.IRDEIDQaL
13 LK.....EEEIQYRGLD...GNT....I....KTTTAKKL.SVIIHARLREIMSK.SKKFFRE.V
14 ADe....RDMISIPPIGeddRDQ....P....SQVSRALV.TRIVRARIEETLEL.IRDRIQK.S
15 VDd....EDVVKIKPRG...EDR....E....IPIQKKQV.AEIIQSRVEEIVEK.VFKEIKA.R
16 LEsq...METVIIPNLG...TRP....P....QEKSRKEL.SVIINSRLREIFEM.MKAEILK.R
17 LEsq...METVIIPNLG...TRP....P....QEKSRKEL.SVIINSRLREIFEM.MKAEILK.R
18 ADd....RCMINVLEIGn..GHH....E....TEYPRAVL.GRIIRARVEEILEM.MRDRLNR.S
19 AS.....KETFQVEVIG...EVE....A....VEVTEAYL.SEIISARIKHILEQ.IKQELDR.R
20 GAetpsqSVQIPTTGSD...GHE....S....HIVPLSEI.QTIMRERALETFKI.IHRSIQD.S
21 TSa....NEEFPVDVIG...QSE....P....VKVDERYL.SEVISARMEQIFNK.AKEALDQ.I
22 GEetpsqNVQIPTTGSD...GHE....S....HIVPLSEI.QTIMRERALETFKI.IHRSIQD.S
23 RDn....HEMIDVAPIA...NDEdvidP....QRISRAQL.IGVIRKRLDHWMDH.IADALKS.L
24 LEg....EGSVLISSQG...NRI....P....VEISKREI.AEIIEARMCEVFTI.VRDRLST.V
25 QP.....NTLIQIPSMGd..ERK....V....NEVSLDII.SNVIYARAEETLMI.LAKILSD.N
26 ASq....DEYFLVDVVG...KDE....P....EQITEYYL.SQIIEARMTQVFNR.VRQDLEH.G
27 FEkds..IINMDDFHVDip.HNL....N....ISLTIYRL.AEVISARAEEILSM.VKAEYDK.A
28 TSa....NEEFPVDVIG...KSE....P....VRVDERYL.SEIIEARVEQILRK.SKEVLDE.I
29 QT.....SIEIDSLYEG...IDF....Y....TSITRARF.EELCQDLFRSTMEP.VERVLRD.A
30 RHeei..SIRGRDMVSG...LPR....T....ITVNSKEV.EEALRESVAVIVQA.AKQVLER.T
31 SDeht..EIRGRDLVSG...LPK....T....VVISAAEV.RKAIEEPVNAIVDA.VKTTLDK.C
32 PPltm..EVSGRDQVSG...LLH....T....IELSSDDV.FEAIKDQVREISSA.LRSVLEE.V
33 PPltm..EVSGRDQVSG...LLH....T....IELSSDDV.FEAIKNQVREISSA.LRSVLEE.V
34 PPltm..EVSGRDQVSG...LLH....T....IELSSDDV.FEAIKDQVREISSA.LRSVLEE.V
35 QT.....SIEIDSLYEG...IDF....Y....TSITRARF.EELCQDLFRSTMDP.VERVLRD.A
36 NIekv..EVKGTDAITG...LPR....R....LEIDSVEV.REALKEPITQIVEE.IKRTLAR.T
37 QA.....RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDLFRSTMKP.VQKVLED.S
38 MI.....LLQIKISSLL...NRL....IvmkqYSIPQKDL.SDFIEARVEEIFFE.VFDVLQD.L
39 QA.....RIEIESFYEG...EDF....S....ETLTRAKF.EELNMDLFRSTMKP.VQKVLED.S
40 ESdnm..EIRGRDLLTG...LPK....T....IEITGKEI.SNALRDTVSTIVEA.VKSTLEK.T
41 QA.....RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDLFRSTMKP.VQKVLED.S
42 QA.....RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDLFRSTMKP.VQKVLED.S
43 QA.....RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDLFRSTMKP.VQKVLED.S
44 QA.....RIEIESFYEG...EDF....S....ETLTRAKF.EELNMDLFRSTMKP.VQKVLED.S
45 QA.....RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDLFRSTMKP.VQKVLED.S
46 ESdnm..EIRGRDLLTG...LPK....T....IEITGKEI.SNALRDTVSTIVEA.VKSTLEK.T
47 RSeel..EIRGRDMVTG...LPR....T....ITVCSEEI.TEALKENAAVIVQA.AKGVLER.T
48 QT.....SIEIDSLYDG...IDF....Y....TSITRARF.EELCQDLFRSTMEP.VEKVLRD.S
49 QA.....SIEIDSLYEG...IDF....Y....TSITRARF.EELCADLFRNTMEP.VEKVLRD.S
50 QT.....KIEIESLFDG...EDF....S....ETLTRAKF.EELNMDLFRATLKP.VQKVLED.A
51 IPeam..EIRGRDLVTG...LPK....T....IMLQSNEI.QDAMRESLLHILEA.IRATLED.C
52 SA.....RVDIESLYQG...IDF....S....ETLTRPKF.EEINMHLSKKTMKP.VEQVLKD.G
53 SA.....RVEIESLYQG...IDF....S....ETLTRAKF.EEINMHLFKKTMKP.VEQVLKD.G
54 KElsm..VVKGRDQVSG...LLS....R....IELTSEDV.REAMREYLKEIADA.LKMVLEM.M
55 QA.....RIEIESFFEG...EDF....S....ETLTRAKF.EELNMDLFRSTMKP.VQKVLED.S
56 QA.....TIEIDSLFEG...IDY....S....VSISRARF.EELCMDYFRNSLLP.VEKVLKD.S
57 QA.....TIEIDSLFEG...IDY....S....VSISRARF.EELCMDYFRNSLLP.VEKVLKD.S
58 QA.....TIEIDSLFEG...IDY....S....VSISRARF.EELCMDYFRNSLLP.VEKVLKD.S
59 QA.....RIEIESFYEG...EDF....S....ETLTRAKF.EELNMDLFRSTMKP.VQKVLED.S
60 QA.....SIEIDSLFEG...VDF....Y....TSITRARF.EELCSDLFRGTLEP.VEKSLRD.A
61 SDeht..EIRGRDLVSG...LPK....T....VVISAAEV.RKAIEEPVNAIVDAgSRTTLDK.C
62 ST.....RIEIDSFVDG...IDL....S....ETLTRAKF.EELNLDLFKKTLKP.VEKVLQD.S
63 EA.....CVEVDSLFEG...IDL....C....TKITRARF.EELCADLFRKTLEP.VEKALRD.A
64 QV.....KIEIESFFEG...DDS....S....ETLTRAKF.EELNMDLFRSTLKP.VQKVLED.A
65 EA.....SIEIDSLYEG...IDF....Y....TKITRARF.EELCGDLFRSTLQP.VETALRD.A
66 EA.....SIEIDSLYEG...IDF....Y....TKITRARF.EELCGDLFRSTLQP.VETALRD.A
67 RHeei..SIRGRDMVSG...LPR....T....ITVNSKEV.EEALRESVAVIVQA.AKQVLER.T
68 ST.....QIEIEDILEG...HNF....S....ETLTRAKF.EELNDDLFRETLEP.VKKVLDD.A
69 EN.....NEIDNTLSYS...IDA....D....RQIESRKF.IEIVEGRVEEI---.----IEN.A
70 RHeei..SIRGRDMVSG...LPR....T....ITVNSKEV.EEALRESVAVIVQA.AKQVLER.T
71 EA.....TVEVDSLFDG...TDF....Y....SKITRARF.EELCADLFRKTLEP.VEKALRD.A
72 VK.....NI--------...LDR....E....IELNVREV.SEAIKPVVDQITTE.ISTVVTE.L
73 KS.....NGSFRMTFAD...KFS....E....REFRSSEV.NRLAKARMDEITAN.YLNILRL.S
74 QA.....TIEIDSLFEG...IDY....S....VSISRARF.EELCMDYFRNSLLP.VEKVLKD.S
75 QNlr6kiDIKGTDAVTG...LPR....K....QLVDSMEV.RESLQEPINVVVDE.VKRTLGA.T
76 QT.....SIEIDSLYEG...IDF....Y....TSITRARF.EELCQDLFRSTMDP.VERVLRD.A
77 QA.....TIELDSLYEG...IDY....N....TTISRARF.EELCNEKFRSTLVP.VEKALES.S
78 QA.....SIEIDALYEG...IDF....Y....TTLTKPRF.EELNNDLFKKTTEC.VEKAVRD.A
79 AGa....GETIKVPTVG...DRP....P....GELSRQAL.AEVVEPRYDELFTL.VQAELRR.S
80 ST.....QIEIEDIVEG...HNF....S....ETLTRAKF.EELNDDLFRETLEP.VKKVLDD.A
81 IN.....LPFITADASGa..KHL....N....ITLTRSKF.ETLVNHLIERTRNP.CKNCLKD.A
82 QV.....NIEIENFMDG...EDF....T....ETLTRARF.EEINNDLFKKCMGP.VDQVLKD.A
83 IN.....LPFITADQTGp..KHL....T....MKLTRAKF.EALVDDLIQKTVEP.CRKALKD.A
84 QD.....RIEIENLADG...VDF....S....FTLTRAKF.EELNMDLFKSTIAP.VKKVLED.S
85 IN.....LPFITADASGa..KHL....N....ITLTRSKF.ETLVNNLIERTRNP.CKNCLKD.A
86 EA.....SIEIDSLFEG...IDY....Y....TKVSRARF.EELCGDLFRNTLEP.VETALRD.A
87 IN.....LPYLTMDKAGp..KHM....H....LKLTRAKL.EHLVEPLIKRTIDP.CNKALKD.A
88 QT.....SIEIDSLYEG...IDF....Y....TSITRARF.EELCQDLFRSTMDP.VERVVRD.A
89 IN.....PPFITADASGa..KHL....Q....MSITRAEF.ERLCDPLFERCREP.VTKALKD.A
90 EA.....SIEIDSLFEG...IDY....Y....TKVSRARF.EELCGDLFRNTLEP.VETALRD.A
91 INl....PFIIADASGP...KHL....T....MKLTRARF.EQLVEDLLQKSVGP.CKQALSD.A
92 ST.....NIAIDALYEG...FDF....F....SKITRARF.EEMCRDQFERCLEP.VRKVLKD.A
93 QT.....TIEIDSLFEG...IDF....N....ATITRAKF.EELNIDLFRGCLEP.VEKVLRD.A
94 IQ.....LPFITADASGp..KHL....V....MKLTRAKF.EALVEPLLKRLMPP.VEQAIKD.A
95 INl....PFITAEPSRP...KHL....E....LTLTRAKFdQDLTKSLVDRTRIP.CEKHLRD.A
96 QT.....TIEIDSLYEG...IDF....Y....STITRARF.EELNMDLFRKCMEP.VEKCLRD.A
97 QT.....MVEVDSLYQG...EDF....S....ASITRARF.EEINAVLFKSTLEP.VEKVLKD.A
98 --.....----------...---....P....QEKSRKEL.SVIINSRLREIFEM.MKAEILK.R
99 EF.....FAQIENLIED...IDF....K....LPVTREKL.EQLCEDLWPRATKP.LEEALAS.S
320 330 340 350 360 370 3
| | | | | |
1 EAKIVEEG.EIGIPGGVVLTGGGAKIPRINELATEVF.KSP.VRTGCYANSDRPSIINADEVAND
2 GY------.EDLIPAGIVLTGGTSKMEGAVELAEEIF.HMP.VRLG-----VPYSVKGLTDVVRN
3 GY------.EDLVPAGIVLTGGTAKMEGAVELAEEIF.HMP.VRLG-----VPHSVRGLSDVVRN
4 QEKLRQQGvKHHLAAGIVLTGGAAQIEGLAACAQRVF.HTQ.VRIG-----APLNITGLTDYAQE
5 QEKLRQQGvKHHLAAGIVLTGGARQIEGLAACAQRVF.HTQ.VRIG-----APLNITGLTDYAQE
6 GF-----P.KEVLNAGIVLTGGVSMMTGIVEFAEKIF.DLP.VRTG-----APQEMGGLSDRVRT
7 GF-----P.KEVLNAGIVLTGGVSMMTGIVEFAEKIF.DLP.VRTG-----APQEMGGLSDRVRT
8 QKKLYKEGrKYQLTGGIVLTGGASTISFLTECAEKIF.QKK.IRIA-----KPLNISGLTDNVTE
9 KAELEAKHiKFELIAGVVITGGGAQIEDLKECASNVF.HCQ.VRIA-----SPLNITGLTDYVNR
10 GI------.-TDLPGGFVLTGGQAAMPGVMSLAQDVL.QNN.VRVQ------GPNYIGV----RD
11 GF------.SPIVGKRIVLTGGASQLTGLPEAARRIL.ARN.VRIG-----RPLGVSGLPAAAKG
12 GP------.VELVAQSVVLTGGGAQLPGAVDLARERF.RLP.TRLG-----RPRGIHGLSDIVGD
13 EAKIVEEG.EIGIPGGVVLTGGGAKIPRINELATEVF.KSP.VRTGCYANSDRPSIINADEVAND
14 GF------.SPIVGKRVVLTGGASQLTGLPETARRIL.ARN.VRIG-----RPMGVAGLPVAAKG
15 GV-----P.LNQINSGIVVTGGTANLKGIRELIEHMT.GLP.VRIG-----LPQGIVGLREKIEN
16 GL------.YNKINGGIVLTGGGALFPGISNLIEEVF.NYP.ARIG-----LPMSINGIGEEHID
17 GL------.YNKINGGIVLTGGGALFPGISNLIEEVF.NYP.ARIG-----LPMSINGIGEEHID
18 GF------.GHIIGKRVILTGGASQLTGLPEMARNIL.GRN.VRIG-----RPLGISRLPSFAKG
19 RL------.-LDLPGGIVLIGGNAILPGMVELAQEVF.GVR.VKLY------VPNQVGI----RN
20 GF------.EEHLGGGVVLTGGMALMKGIKELARTHFtNYP.VRLA--TPVEKYNIMGMFEDLKD
21 EA------.-LELPGGIVLTGGAASLPGVVDLAQEIF.GVN.VKLY------VPNQMGL----RN
22 GL------.EEHLGGGVVLTGGMALMKGIKELARTHFtNYP.VRLA--APVEKYNIMGMFEDLKD
23 GY------.NGPVGRQVVLTGGGAELKGIADYAQGVL.GRS.VRIG-----RPHGLVGLPDAHSG
24 ET----QS.GRGIIENIILCGGGAQLTGAVELASAIF.DTPrVHLG-----IPGTLGGLAGEYRS
25 RY------.ANAIGGGVVLTGGMTKLAGIDELAPATFdNRS.VRLA---TARKDLITGFSEIFND
26 HT------.-SETPGGLILVGGTAAMPGVVDLATKIL.GMN.ARLY------VPGEMGL----RN
27 TK------.GQFEVFRVVITGGGSQLRGLKELSNKIF.AKQ.SRIG-----KPEIIAGFTEDYNP
28 DA------.-FELPGGVVLTGGAASIARYCRFRRKRFlEAN.VKLY------VPNHMGL----RN
29 KI------.DKSSVHEIVLVGGSTRIPRIQKLVSDFFnGKE.PNKS-----------------IN
30 PP---ELS.ADIIDRGVIITGGGALLNGLDQLLAEEL.KVP.VLVA-----------------EN
31 PP---ELS.GDIMDRGIVLTGGGALLRGLDERLRRET.GMP.IHIA-----------------ED
32 KP---DLA.KDIVQNGVVLTGGGALIKGLDKYLSDMV.KLP.VYVG-----------------DE
33 KP---DLV.KDIVQNGVVLTGGGALIKGLDKYLSDMV.KLP.VYVG-----------------DE
34 KP---DLV.RDIVQNGVVLTGGGALIKGLDKYLSDMV.KLP.VYVG-----------------DE
35 KI------.DKSSVHEIVLVGGSTRIPRIQKLVSDFFnGKE.PNKS-----------------IN
36 PP---ELA.ADIVERGIVMTGGGSLLKGLPKLISKET.HVP.VILA-----------------EN
37 DL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-----------------IN
38 GL------.-TKVNGGFIVTGGSANLLGVKELLSDMV.SEK.VRIH------TPSQMGI----RK
39 DL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-----------------IN
40 PP---ELA.ADIMDRGIVLTGGGALLRNLDKVISEET.KMP.VLIA-----------------ED
41 DL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-----------------IN
42 DL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-----------------IN
43 DL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-----------------IN
44 DL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-----------------IN
45 DL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-----------------IN
46 PP---ELA.ADIMDRGIVLTGGGALLRNLDKVISEET.KMP.VLIA-----------------ED
47 PP---ELS.ADIIDRGVILTGGGALLHGIDMLLAEEL.KVP.VLIA-----------------EN
48 KI------.DKSSVNEIVLVGGSTRIPKIQKLVSDMFsGRE.PNRS-----------------IN
49 KI------.DKSSVNEIVLVGGSTRIPRIQKLVSDFF.NGK.EPCK----------------SIN
50 DM------.KKTDVHEIVLVGGSTRIPKVQQLIKDYFnGKE.PSRG-----------------IN
51 PP---ELS.GDIVDRGVILTGGGALLNGIKEWLTEEI.VVP.VHVA-----------------QN
52 NV------.KKSDIDDIVLVGGSTRIPKVQQLLEDYFdGKK.VSKS-----------------IN
53 NV------.KKSDIDDIVLVGGSTRIPKVQQLLEEFFdGKK.VSKS-----------------IN
54 PP---DLA.SDIVENGVVLTGGGALIRGLDKYLSEIV.RLP.VYIA-----------------DE
55 DL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-----------------IN
56 GI------.DKRSVSEVVLVGGSTRIPKIQQLITDFF.NGK.EPCR----------------SIN
57 GI------.DKRSVSEVVLVGGSTRIPKIQQLITDFF.NGK.EPCR----------------SIN
58 GI------.DKRSVSEVVLVGGSTRIPKIQQLITDFF.NGK.EPCR----------------SIN
59 DL------.KKSDIDEIVLVGGSTRIPKIQQLVKEFFnGKE.PSRG-----------------IN
60 KL------.DKGQIHDVVLVGGSTRIPKIQKLLQDFFnGRE.LNKS-----------------IN
61 PP---ELS.GDIMDRGIVLTGGGALLPGLDERLRRET.GMP.IHIA-----------------ED
62 GL------.EKKDVDDIVLVGGSTRIPKVQQLLESYFdGKK.ASKG-----------------IN
63 KL------.DKSKIDEVVLVGGSTRVPKIQKLLKDFFnGKE.LNCS-----------------IN
64 DM------.NKKDVDEIVLVGGSTRIPKVQQLVKEFFnGKE.PSRG-----------------IN
65 KL------.DKGKIDEVVLVGGSTRIPKVQKLLTDFFnGKE.LNKS-----------------IN
66 KL------.DKGKIDEVVLVGGSTRIPKVQKLLTDFFnGKE.LNKS-----------------IN
67 PP---ELS.ADIIDRGVIITGGGALLNGLDQLLAEEL.KVP.-----------------------
68 KY------.EKSKIDEIVLVGGSTRIPKIQQIIKEFFnGKE.PNRG-----------------IN
69 WFQVPNEY.ADKLLGGIILTGGGSNMPNIEKAFRSHT.HIE.-----------------------
70 PP---ELS.ADIIDRGVIITGGGALLNGLDQLLAEE-.---.-----------------------
71 KT------.DKGRIDEVVLVGGSTRIPKIQKLLKEFFnGKD.LNCS-----------------IN
72 NG------.--GAPSVVMVVGGGAKVPGFVESLARKL.DLPlDRVSLKSVESTGLVEDLTGKVKG
73 GL------.LEDIGAGIILNGGGTKINNYMAAMKKIL.G--.-----------------------
74 GI------.DKRSVSEVVLVGGSTRIPKIQQLITDFF.NGK.EPCR----------------SIN
75 PP---ELA.TDIVERGIILTGGGALLKGLNRLLSKET.GVP.VYVA-----------------DN
76 KI------.DKSSVHEIVLVGGSTRIPRIQKLVSDFFnGKE.PNKS-----------------IN
77 GL------.DKRSIHEVVLVGGSTRIPKIQSLIKSFF.NGK.EPCR----------------SIN
78 KM------.EKGEIHEIVLVGGSTRIPKIQKLLEDFFkGKS.LNKS-----------------IN
79 GY------.EDLIPAGIVLTGGTSKMEGAVELAEEIF.HMP.VRLG-----VPYSVKGLTDVVRN
80 KY------.EKSKIDEIVLVGGSTRIPKIQQIIKEFFnGKE.PNRG-----------------IN
81 GV------.SLKDVDEVLLVGGMTRVPKVQEIVSEIF.GKS.PSKG-----------------VN
82 GL------.SKSEIDDVVLVGGSTRIPKVQQLVKSFFnGKE.PSKA-----------------VN
83 GV------.TAGEIGEVVLVGGMSRMPKVQEVVKQLF.GKE.PHKG-----------------VN
84 KM------.SKGAIHEVVLVGGSTRIPKVQQLLKEFFnGKE.PSRG-----------------IN
85 GV------.SLKDVDEVLLVGGMTRVPKVQEIVSEIF.GKS.PSKG-----------------VN
86 KL------.DKGKIDEVVLVGGSTRIPKIQKLLTDFFnGKE.LNKS-----------------IN
87 EV------.KASDIGEIILVGGMTRMPKVQETVEKIF.GKT.PSKS-----------------VN
88 KI------.DKSSVHEIVLVGGSTRIPRIQKLVSDFFnGKE.PNKS-----------------IN
89 KL------.DPKEIDEVVLVGGSTRIPKVQELVREMF.GKE.PHKG-----------------VN
90 KL------.DKGKIDEVVLVGGSTRIPKIQKLLTDFF.N--.-----------------------
91 GV------.KPEQIDEVVLVGGSTRIPRVQQIVRDLF.KKE.PHKG-----------------VN
92 EV------.DASAVDDVVLVGGSTRIPRVQQLVQNFF.N--.-----------------------
93 KV------.DKGTIHDIVLVGGSSRIPKVQQLLRDFF.NGK.ELCQ----------------SIN
94 GL------.EPKDIEEIVLVGGSTRIPKVQEMVKGFF.GKE.PNKS-----------------VN
95 GL------.KASDINEVILVGGGLRIPAVQELVKQVF.GKE.PNKS-----------------VN
96 KM------.DKSTVHDVVLVGGSTRIPRVQQLLQDFF.NGK.ELCK----------------NIN
97 KM------.AHEKVDDIVLVGGSTRIPKVQALVSEYFgGRQ.LNKS-----------------IN
98 GL------.YNKINGGIVLTGGGALFPGISNLIEEVF.NYP.ARIG-----LPMSINGIGEEHID
99 HL------.SLDVINQVILFGGGTRVPRVQETIKAVI.KQE.LGKN-----------------LN
80 390 400 410
| | | |
1 PSFAAAFGNV.....FAVSE.....NPYE.....ETPVKSE.NPL...KKIFRLFKELME
2 PIYSTGVGLL.....MYGLQ.....KQSDgm7vsGSSYSSD.EPK...APVLERLKRWV-
3 PIYSTGVGLL.....TYGLL.....KQSE.....DLA----.---...------------
4 PYYSTAVGLL.....HYGKE.....SHLN.....GEAEVEK.RVT...ASVGSWIKRL--
5 PYYSTAVGLL.....HYGKE.....SHLN.....GEAEVEK.RVT...ASVGSWIKRL--
6 PRFSTAIGLL.....HAACKlegnlPQLE.....NGAVQER.EGG...GGLLARLKRWIE
7 PRFSTAIGLL.....HAACKlegnlPQPE.....NGAVQER.EGG...GGLLARLKRWIE
8 PHYSTVVGLL.....HYGKE.....FYFD.....DTNQKREiSFI...EKWFQKISNWF-
9 PQYSTVVGLL.....QYNYS.....NSDD.....DLISGSD.DSE...GTFFES------
10 PQYMTGVGLI.....QFACR.....----.....-------.---...------------
11 PAFSTAVGLM.....IYPQV.....ADLE.....THA----.---...------------
12 PAHACSVGMV.....LYGI-.....----.....-------.---...------------
13 PSFAAAFGNV.....FAVSE.....NPYE.....ETPVKSE.NPL...KKIFRLFKELME
14 PAFSTACGLM.....IYPQV.....ADIE.....IHA----.---...------------
15 PKYATVCGLLrqaf.VSGTI.....DITE.....STNSNTG.NFF...KNLSERFKKWFE
16 PKFSSALGLV.....LYKHE.....QQ--.....-------.---...------------
17 PKFSSALGLV.....LYKHE.....QQ--.....-------.---...------------
18 ATFSSAVGLL.....IYPQL.....VGFE.....KK-----.---...------------
19 PAFAHVIS--.....-----.....----.....-------.---...------------
20 PRFSVVVGLI.....LYKAG.....GHTN.....YERDS--.---...------------
21 PVFTNVISIV.....DY---.....----.....-------.---...------------
22 PRFSVVVGLI.....LYKAG.....GHTN.....YERDSK-.---...------------
23 PAFATLTGLV.....LHAAS.....EPFD.....LRPLSYN.NRIgsqKSFMG-------
24 PEFAVVLGLI.....LEYTH.....K---.....-------.---...------------
25 PENTCAIGLC.....LYGAG.....YFTP.....YELDSNE.KL-...------------
26 PAFAQVISVV.....-----.....----.....-------.---...------------
27 AMYSAAIGMLkiha.LKQQK.....ALSH.....IRLDENI.NFF...KKAFDWFKE---
28 PVFANVISIV.....EYS--.....----.....-------.---...------------
29 PDEAVAYGAA.....VQAA-.....----.....-------.---...------------
30 PMDCVAIG--.....-----.....----.....-------.---...------------
31 PLDSVALG--.....-----.....----.....-------.---...------------
32 PLLAVAKG--.....-----.....----.....-------.---...------------
33 PLLAVAKG--.....-----.....----.....-------.---...------------
34 PLLAVAKG--.....-----.....----.....-------.---...------------
35 PDEAVAYGAA.....VQAA-.....----.....-------.---...------------
36 PMNCVAIG--.....-----.....----.....-------.---...------------
37 PDEAVAYGAA.....-----.....----.....-------.---...------------
38 PEFSSAISTIsssiaFDELL.....DYVT.....INYHDNE.ETE...EDVIDVKDK---
39 PDEAVAYGAA.....-----.....----.....-------.---...------------
40 PLDCVAIG--.....-----.....----.....-------.---...------------
41 PDEAVAYGAA.....-----.....----.....-------.---...------------
42 PDEAVAYGAA.....-----.....----.....-------.---...------------
43 PDEAVAYGAA.....-----.....----.....-------.---...------------
44 PDEAVAYGAA.....-----.....----.....-------.---...------------
45 PDEAVAYGAA.....-----.....----.....-------.---...------------
46 PLDCVAIG--.....-----.....----.....-------.---...------------
47 PMHCVAVG--.....-----.....----.....-------.---...------------
48 PDEAVAYGAA.....V----.....----.....-------.---...------------
49 PDEAVAYGAA.....VQ---.....----.....-------.---...------------
50 PDEAVAYGA-.....-----.....----.....-------.---...------------
51 PLESVAIG--.....-----.....----.....-------.---...------------
52 PAEAVAYGAT.....-----.....----.....-------.---...------------
53 PDEAVAYGAT.....-----.....----.....-------.---...------------
54 PLLAVAKG--.....-----.....----.....-------.---...------------
55 PDEAVAYGAA.....-----.....----.....-------.---...------------
56 PDEAVAYGAA.....-----.....----.....-------.---...------------
57 PDEAVAYGAA.....-----.....----.....-------.---...------------
58 PDEAVAYGAA.....-----.....----.....-------.---...------------
59 PDEAVAYGAA.....-----.....----.....-------.---...------------
60 PDEAVAYGAA.....V----.....----.....-------.---...------------
61 PLDSVALG--.....-----.....----.....-------.---...------------
62 PDEAVAYGAA.....-----.....----.....-------.---...------------
63 PDEAVAFGAA.....-----.....----.....-------.---...------------
64 PDEAVAYGAA.....-----.....----.....-------.---...------------
65 PDEAVAYGAA.....V----.....----.....-------.---...------------
66 PDEAVAYGAA.....V----.....----.....-------.---...------------
67 ----------.....-----.....----.....-------.---...------------
68 PDEAVAYGAA.....-----.....----.....-------.---...------------
69 ----------.....-----.....----.....-------.---...------------
70 ----------.....-----.....----.....-------.---...------------
71 PDEAVAFGAA.....-----.....----.....-------.---...------------
72 SEYITPVGIA.....YSAMR.....----.....-------.---...------------
73 ----------.....-----.....----.....-------.---...------------
74 PDEAVAYGAA.....-----.....----.....-------.---...------------
75 PLLSVAVGA-.....-----.....----.....-------.---...------------
76 PDEAVAYGAA.....VQAA-.....----.....-------.---...------------
77 PDEAVAYGAA.....VQ---.....----.....-------.---...------------
78 PDEAVAYGAA.....VQ---.....----.....-------.---...------------
79 PIYSTGVGLL.....MYGLQ.....KQSDgm7vsGSSYSSD.EPK...APVLERLKRWV-
80 PDEAVAYGAA.....-----.....----.....-------.---...------------
81 PDEAVAMGAA.....L----.....----.....-------.---...------------
82 PDEAVAHGAA.....VQA--.....----.....-------.---...------------
83 PDEVVAIGAA.....-----.....----.....-------.---...------------
84 PDEAVAYGAA.....-----.....----.....-------.---...------------
85 PDEAVAMGAA.....L----.....----.....-------.---...------------
86 PDE-------.....-----.....----.....-------.---...------------
87 PDEAVAMGAA.....I----.....----.....-------.---...------------
88 PDEAVAYGAA.....VQAAI.....----.....-------.---...------------
89 PDEAV-----.....-----.....----.....-------.---...------------
90 ----------.....-----.....----.....-------.---...------------
91 PDEAV-----.....-----.....----.....-------.---...------------
92 ----------.....-----.....----.....-------.---...------------
93 PDEAVAYGAV.....QAA--.....----.....-------.---...------------
94 PDEAV-----.....-----.....----.....-------.---...------------
95 PDEVVAIGAA.....-----.....----.....-------.---...------------
96 PDEAVAYGAA.....VQ---.....----.....-------.---...------------
97 P---------.....-----.....----.....-------.---...------------
98 PKFSSALGLV.....LYKHE.....QQ--.....-------.---...------------
99 ADESATMGAV.....Y----.....----.....-------.---...------------